JP2004527244A5 - - Google Patents
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- Publication number
- JP2004527244A5 JP2004527244A5 JP2002577907A JP2002577907A JP2004527244A5 JP 2004527244 A5 JP2004527244 A5 JP 2004527244A5 JP 2002577907 A JP2002577907 A JP 2002577907A JP 2002577907 A JP2002577907 A JP 2002577907A JP 2004527244 A5 JP2004527244 A5 JP 2004527244A5
- Authority
- JP
- Japan
- Prior art keywords
- kinase receptor
- species
- test compound
- test
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000005962 receptors Human genes 0.000 claims 23
- 108020003175 receptors Proteins 0.000 claims 23
- 108091000080 Phosphotransferase Proteins 0.000 claims 19
- 102000020233 phosphotransferase Human genes 0.000 claims 19
- 238000000034 method Methods 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 13
- 241000894007 species Species 0.000 claims 10
- 239000008280 blood Substances 0.000 claims 5
- 210000004369 blood Anatomy 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 5
- 238000001727 in vivo Methods 0.000 claims 5
- 241000699670 Mus sp. Species 0.000 claims 3
- 230000036755 cellular response Effects 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 241000282472 Canis lupus familiaris Species 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 241000700159 Rattus Species 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 230000026731 phosphorylation Effects 0.000 claims 2
- 238000006366 phosphorylation reaction Methods 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 230000008520 organization Effects 0.000 claims 1
- 229940068196 placebo Drugs 0.000 claims 1
- 239000000902 placebo Substances 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28077101P | 2001-04-02 | 2001-04-02 | |
| PCT/US2002/009758 WO2002079498A1 (en) | 2001-04-02 | 2002-03-29 | In vivo methods of determining activity of receptor-type kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004527244A JP2004527244A (ja) | 2004-09-09 |
| JP2004527244A5 true JP2004527244A5 (https=) | 2005-12-22 |
Family
ID=23074563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002577907A Withdrawn JP2004527244A (ja) | 2001-04-02 | 2002-03-29 | 受容体型キナーゼ阻害剤の活性のインビボ測定方法 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1385983A4 (https=) |
| JP (1) | JP2004527244A (https=) |
| CA (1) | CA2443144A1 (https=) |
| WO (1) | WO2002079498A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
| EP2344470B1 (en) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| JP5690277B2 (ja) | 2008-11-28 | 2015-03-25 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体 |
| AU2010232729A1 (en) | 2009-03-31 | 2011-10-20 | Arqule, Inc. | Substituted indolo-pyridinone compounds |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| AU2011328203B2 (en) | 2010-11-08 | 2015-03-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| MX386697B (es) | 2014-01-21 | 2025-03-19 | Janssen Pharmaceutica Nv | Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso |
| ME03518B (me) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9300059D0 (en) * | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| US5783568A (en) * | 1994-06-10 | 1998-07-21 | Sugen, Inc. | Methods for treating cancer and other cell proliferative diseases |
| US6271233B1 (en) * | 1999-08-10 | 2001-08-07 | Ciba Vision Corporation | Method for treating ocular neovascular diseases |
-
2002
- 2002-03-29 WO PCT/US2002/009758 patent/WO2002079498A1/en not_active Ceased
- 2002-03-29 CA CA002443144A patent/CA2443144A1/en not_active Abandoned
- 2002-03-29 JP JP2002577907A patent/JP2004527244A/ja not_active Withdrawn
- 2002-03-29 EP EP02719386A patent/EP1385983A4/en not_active Withdrawn
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