JP2004520365A - クルジパインおよび他のシステインプロテアーゼの阻害剤 - Google Patents
クルジパインおよび他のシステインプロテアーゼの阻害剤 Download PDFInfo
- Publication number
- JP2004520365A JP2004520365A JP2002557927A JP2002557927A JP2004520365A JP 2004520365 A JP2004520365 A JP 2004520365A JP 2002557927 A JP2002557927 A JP 2002557927A JP 2002557927 A JP2002557927 A JP 2002557927A JP 2004520365 A JP2004520365 A JP 2004520365A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- oxo
- furan
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 **N[C@](CCC1)([C@]1*C1*)C1=O Chemical compound **N[C@](CCC1)([C@]1*C1*)C1=O 0.000 description 5
- NLOVAVGWLLSCAP-UHFFFAOYSA-N CC1=C(c2ccccc2)ON[N]1 Chemical compound CC1=C(c2ccccc2)ON[N]1 NLOVAVGWLLSCAP-UHFFFAOYSA-N 0.000 description 1
- HEAWCKCNBSRSHF-UHFFFAOYSA-N CC1=N[C](c2ccccc2)NO1 Chemical compound CC1=N[C](c2ccccc2)NO1 HEAWCKCNBSRSHF-UHFFFAOYSA-N 0.000 description 1
- GRKGWGBPHASXFD-UHFFFAOYSA-N CN1O[N]C(c2ccccc2)=N1 Chemical compound CN1O[N]C(c2ccccc2)=N1 GRKGWGBPHASXFD-UHFFFAOYSA-N 0.000 description 1
- IWDQSSCSYLMMRP-UHFFFAOYSA-N C[C]1ON=C(C2C=CC=CC2C)N1 Chemical compound C[C]1ON=C(C2C=CC=CC2C)N1 IWDQSSCSYLMMRP-UHFFFAOYSA-N 0.000 description 1
- ZZLCFHIKESPLTH-UHFFFAOYSA-N Cc(cc1)ccc1-c1ccccc1 Chemical compound Cc(cc1)ccc1-c1ccccc1 ZZLCFHIKESPLTH-UHFFFAOYSA-N 0.000 description 1
- GHCFFXKWEYJERM-UHFFFAOYSA-N Cc(cc1)ccc1C1=NNO[N]1 Chemical compound Cc(cc1)ccc1C1=NNO[N]1 GHCFFXKWEYJERM-UHFFFAOYSA-N 0.000 description 1
- LKNIWGKHHMIXSI-UHFFFAOYSA-N Cc(cc1)ccc1C1=NO[N]N1 Chemical compound Cc(cc1)ccc1C1=NO[N]N1 LKNIWGKHHMIXSI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0101204.6A GB0101204D0 (en) | 2001-01-17 | 2001-01-17 | Biologically active compounds |
| US27550601P | 2001-03-13 | 2001-03-13 | |
| PCT/GB2002/000194 WO2002057246A2 (en) | 2001-01-17 | 2002-01-17 | Inhibitors of cruzipain and other cysteine proteases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004520365A true JP2004520365A (ja) | 2004-07-08 |
| JP2004520365A5 JP2004520365A5 (https=) | 2005-12-22 |
Family
ID=26245574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002557927A Pending JP2004520365A (ja) | 2001-01-17 | 2002-01-17 | クルジパインおよび他のシステインプロテアーゼの阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6958358B2 (https=) |
| EP (1) | EP1358176A2 (https=) |
| JP (1) | JP2004520365A (https=) |
| CA (1) | CA2434068A1 (https=) |
| IL (1) | IL156776A0 (https=) |
| NZ (1) | NZ526912A (https=) |
| WO (1) | WO2002057246A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004523506A (ja) * | 2000-12-22 | 2004-08-05 | アクシス・ファーマシューティカルズ・インコーポレイテッド | カテプシン阻害剤としての新規な化合物と組成物 |
| US20040147503A1 (en) * | 2002-06-04 | 2004-07-29 | Sheila Zipfeil | Novel compounds and compositions as cathepsin inhibitors |
| CA2569887A1 (en) | 2004-06-09 | 2005-12-22 | Glaxo Group Limited | Pyrrolopyridine derivatives |
| AU2006316321A1 (en) * | 2005-11-22 | 2007-05-31 | Merck & Co., Inc. | Indole orexin receptor antagonists |
| GB0614042D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| EP2719700A1 (en) | 2008-01-09 | 2014-04-16 | Amura Therapeutics Limited | Tetrahydrofuro(3,2-b)pyrrol-3-one derivatives as inhibitors of cysteine proteinases |
| US20110046044A1 (en) * | 2009-08-24 | 2011-02-24 | Samsung Electronics Co., Ltd. | Use of a cysteine protease of Plasmodium vivax |
| US9409880B2 (en) | 2011-01-20 | 2016-08-09 | The Regents Of The University Of Colorado, A Body Corporate | Modulators of TLR3/dsRNA complex and uses thereof |
| WO2026037930A1 (en) * | 2024-08-16 | 2026-02-19 | Anavo Therapeutics Bv | Amide derivatives as wip1 inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652574A (en) | 1970-04-01 | 1972-03-28 | Abbott Lab | Certain 1 2 3 4 - tetrahydro-5h-pyrido (4 3-b)indoles and the corresponding 1 2 3 4-tetrahydro-9h-pyrido(3 4-b)indoles and derivatives thereof |
| DZ2285A1 (fr) | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
| EP0923535A4 (en) | 1996-08-28 | 2001-01-10 | Smithkline Beecham Corp | CYSTEINE PROTEASE INHIBITORS |
| EA002100B1 (ru) | 1996-12-23 | 2001-12-24 | Элан Фармасьютикалз, Инк. | ЦИКЛОАЛКИЛЬНЫЕ СОЕДИНЕНИЯ, ЛАКТАМЫ, ЛАКТОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ВЫСВОБОЖДЕНИЯ И/ИЛИ СИНТЕЗА β-АМИЛОИДНОГО ПЕПТИДА С ПОМОЩЬЮ УКАЗАННЫХ СОЕДИНЕНИЙ |
| AR013079A1 (es) * | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios |
| MA26618A1 (fr) | 1998-04-09 | 2004-12-20 | Smithkline Beecham Corp | Composes et compositions pharmaceutiques pour le traitement du paludisme |
| CO5150165A1 (es) * | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | Inhibidores de proteasa: tipo catepsina k |
| GB9911417D0 (en) * | 1999-05-18 | 1999-07-14 | Peptide Therapeutics Ltd | Furanone derivatives as inhibitors of cathepsin s |
| JP2004513942A (ja) | 2000-11-17 | 2004-05-13 | メディヴァー ユーケイ リミテッド | システインプロテアーゼインヒビター |
| JP2004523506A (ja) | 2000-12-22 | 2004-08-05 | アクシス・ファーマシューティカルズ・インコーポレイテッド | カテプシン阻害剤としての新規な化合物と組成物 |
-
2002
- 2002-01-17 JP JP2002557927A patent/JP2004520365A/ja active Pending
- 2002-01-17 WO PCT/GB2002/000194 patent/WO2002057246A2/en not_active Ceased
- 2002-01-17 EP EP02715508A patent/EP1358176A2/en not_active Withdrawn
- 2002-01-17 US US10/466,385 patent/US6958358B2/en not_active Expired - Fee Related
- 2002-01-17 NZ NZ526912A patent/NZ526912A/en unknown
- 2002-01-17 CA CA002434068A patent/CA2434068A1/en not_active Abandoned
- 2002-01-17 IL IL15677602A patent/IL156776A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2434068A1 (en) | 2002-07-25 |
| EP1358176A2 (en) | 2003-11-05 |
| WO2002057246A2 (en) | 2002-07-25 |
| US6958358B2 (en) | 2005-10-25 |
| NZ526912A (en) | 2005-02-25 |
| WO2002057246A3 (en) | 2002-11-21 |
| US20040106805A1 (en) | 2004-06-03 |
| IL156776A0 (en) | 2004-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041220 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20041220 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080722 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090113 |