JP2004517808A5 - - Google Patents
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- Publication number
- JP2004517808A5 JP2004517808A5 JP2002513464A JP2002513464A JP2004517808A5 JP 2004517808 A5 JP2004517808 A5 JP 2004517808A5 JP 2002513464 A JP2002513464 A JP 2002513464A JP 2002513464 A JP2002513464 A JP 2002513464A JP 2004517808 A5 JP2004517808 A5 JP 2004517808A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- pharmaceutical composition
- substituted
- benzyl
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 31
- 239000008194 pharmaceutical composition Substances 0.000 description 20
- 125000003118 aryl group Chemical group 0.000 description 16
- HNYOPLTXPVRDBG-UHFFFAOYSA-N Barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 11
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 11
- 230000004112 neuroprotection Effects 0.000 description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 10
- 229910052739 hydrogen Inorganic materials 0.000 description 9
- 239000001257 hydrogen Substances 0.000 description 9
- 230000001624 sedative Effects 0.000 description 9
- 241000124008 Mammalia Species 0.000 description 8
- 229910052736 halogen Inorganic materials 0.000 description 8
- 150000002367 halogens Chemical class 0.000 description 8
- 150000002431 hydrogen Chemical class 0.000 description 6
- 230000000324 neuroprotective Effects 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- IKVPZYAOGOJTLK-UHFFFAOYSA-N 5,5-diphenyl-1,3-diazinane-2,4,6-trione Chemical compound O=C1NC(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 IKVPZYAOGOJTLK-UHFFFAOYSA-N 0.000 description 5
- RRFBTKHQZRCRSS-UHFFFAOYSA-N 1,3-bis(methoxymethyl)-5,5-diphenyl-1,3-diazinane-2,4,6-trione Chemical compound O=C1N(COC)C(=O)N(COC)C(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 RRFBTKHQZRCRSS-UHFFFAOYSA-N 0.000 description 4
- 206010008120 Cerebral ischaemia Diseases 0.000 description 4
- 201000006474 brain ischemia Diseases 0.000 description 4
- 206010052639 Nerve injury Diseases 0.000 description 3
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 125000002877 alkyl aryl group Chemical group 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 125000005842 heteroatoms Chemical group 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- SQCVEQVZGPHNTJ-UHFFFAOYSA-N 1-(methoxymethyl)-5,5-diphenyl-1,3-diazinane-2,4,6-trione Chemical compound O=C1N(COC)C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 SQCVEQVZGPHNTJ-UHFFFAOYSA-N 0.000 description 2
- 208000008208 Craniocerebral Trauma Diseases 0.000 description 2
- 206010044390 Transient ischaemic attack Diseases 0.000 description 2
- 201000010875 transient cerebral ischemia Diseases 0.000 description 2
- 0 *C(*)(C(N(*)C(N1*)=O)=O)C1=O Chemical compound *C(*)(C(N(*)C(N1*)=O)=O)C1=O 0.000 description 1
- 206010003658 Atrial fibrillation Diseases 0.000 description 1
- 208000009361 Bacterial Endocarditis Diseases 0.000 description 1
- 230000036868 Blood Concentration Effects 0.000 description 1
- 206010008118 Cerebral infarction Diseases 0.000 description 1
- 206010014666 Endocarditis bacterial Diseases 0.000 description 1
- 206010042316 Subarachnoid haemorrhage Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22167200P | 2000-07-26 | 2000-07-26 | |
| US60/221,672 | 2000-07-26 | ||
| PCT/US2001/023420 WO2002007729A1 (en) | 2000-07-26 | 2001-07-26 | Non-sedating barbiturate compounds as neuroprotective agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004517808A JP2004517808A (ja) | 2004-06-17 |
| JP2004517808A5 true JP2004517808A5 (US07794700-20100914-C00152.png) | 2008-09-11 |
| JP5047442B2 JP5047442B2 (ja) | 2012-10-10 |
Family
ID=22828824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002513464A Expired - Fee Related JP5047442B2 (ja) | 2000-07-26 | 2001-07-26 | 神経保護剤としての非鎮静バルビツレート化合物 |
Country Status (14)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6093820A (en) | 1997-10-02 | 2000-07-25 | Taro Pharmaceutical Industries Ltd. | Method and reagents for N-alkylating ureides |
| US7683071B2 (en) | 2000-07-26 | 2010-03-23 | Taro Pharmaceuticals Industries Ltd. | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid |
| US6939873B2 (en) | 2000-07-26 | 2005-09-06 | Taro Pharmaceuticals Industries Limited | Non-sedating barbituric acid derivatives |
| IL154060A0 (en) * | 2000-07-26 | 2003-07-31 | Taro Pharma Ind | Mon-sedating barbiturate compounds as neuroprotective agents |
| US6756379B2 (en) | 2001-07-26 | 2004-06-29 | Taro Pharmaceutical Industries Ltd. | Non-sedating barbiturate compounds as neuroprotective agents |
| CN1291720C (zh) * | 2002-01-30 | 2006-12-27 | 塔罗制药工业有限公司 | 非镇静性巴比土酸衍生物 |
| AU2003282464B2 (en) | 2002-10-11 | 2010-02-25 | Baxter International, Inc. | Method for cardioprotection and neuroprotection by intravenous administration of halogenated volatile anesthetics |
| DE60324703D1 (de) * | 2002-12-11 | 2008-12-24 | Taro Pharma Ind | Barbitursäure derivaten. |
| EP1625848A1 (en) * | 2004-08-10 | 2006-02-15 | Taro Pharmaceuticals North America, Inc. | Composition and method for enhanced delivery of 5,5-diphenyl barbituric acid |
| US9056817B2 (en) * | 2011-09-12 | 2015-06-16 | Council Of Scientific And Industrial Research | Arylated β-dicarbonyl compounds and process for the preparation thereof |
| CN102863579B (zh) * | 2012-09-14 | 2014-02-05 | 东南大学 | 一种巴比妥酸螯合树脂及其制备方法和应用 |
| CN108351352B (zh) | 2015-10-05 | 2021-09-10 | 北卡罗来纳-查佩尔山大学 | 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL69722A (en) * | 1983-09-14 | 1986-09-30 | Taro Pharma Ind | Oxopyrimidine derivatives and pharmaceutical compositions containing them |
| US4833148A (en) * | 1987-04-09 | 1989-05-23 | Washington University | Method of using alkenyl- or alkynyl-substituted thiobarbiturates to reduce neurotoxic injury |
| US5474990A (en) * | 1989-10-20 | 1995-12-12 | Olney; John W. | Barbiturates as safening agents in conjunction with NMDA antagonists |
| IL154060A0 (en) * | 2000-07-26 | 2003-07-31 | Taro Pharma Ind | Mon-sedating barbiturate compounds as neuroprotective agents |
-
2001
- 2001-07-26 IL IL15406001A patent/IL154060A0/xx unknown
- 2001-07-26 AT AT01959195T patent/ATE383159T1/de not_active IP Right Cessation
- 2001-07-26 DE DE60132337T patent/DE60132337T2/de not_active Expired - Lifetime
- 2001-07-26 AU AU2001280778A patent/AU2001280778B2/en not_active Ceased
- 2001-07-26 CN CNB018151426A patent/CN1329032C/zh not_active Expired - Fee Related
- 2001-07-26 CN CNB2006100813267A patent/CN100522172C/zh not_active Expired - Fee Related
- 2001-07-26 MX MXPA03000824A patent/MXPA03000824A/es active IP Right Grant
- 2001-07-26 JP JP2002513464A patent/JP5047442B2/ja not_active Expired - Fee Related
- 2001-07-26 ES ES01959195T patent/ES2300349T3/es not_active Expired - Lifetime
- 2001-07-26 PT PT01959195T patent/PT1311270E/pt unknown
- 2001-07-26 AU AU8077801A patent/AU8077801A/xx active Pending
- 2001-07-26 EP EP01959195A patent/EP1311270B1/en not_active Expired - Lifetime
- 2001-07-26 CA CA2416535A patent/CA2416535C/en not_active Expired - Fee Related
- 2001-07-26 WO PCT/US2001/023420 patent/WO2002007729A1/en active IP Right Grant
- 2001-07-26 BR BR0112775-6A patent/BR0112775A/pt not_active Application Discontinuation
-
2003
- 2003-01-20 IL IL154060A patent/IL154060A/en not_active IP Right Cessation
-
2004
- 2004-11-03 IL IL16501704A patent/IL165017A0/xx unknown
-
2007
- 2007-06-05 HK HK07105924.3A patent/HK1100814A1/xx unknown
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