JP2004517046A5 - - Google Patents
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- Publication number
- JP2004517046A5 JP2004517046A5 JP2002522936A JP2002522936A JP2004517046A5 JP 2004517046 A5 JP2004517046 A5 JP 2004517046A5 JP 2002522936 A JP2002522936 A JP 2002522936A JP 2002522936 A JP2002522936 A JP 2002522936A JP 2004517046 A5 JP2004517046 A5 JP 2004517046A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- channel
- pharmaceutical composition
- individual
- channel activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108091006146 Channels Proteins 0.000 claims 36
- 239000003795 chemical substances by application Substances 0.000 claims 31
- 201000001880 Sexual dysfunction Diseases 0.000 claims 22
- 231100000872 sexual dysfunction Toxicity 0.000 claims 22
- 230000000694 effects Effects 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 239000003814 drug Substances 0.000 claims 13
- 210000004392 genitalia Anatomy 0.000 claims 8
- 210000002460 smooth muscle Anatomy 0.000 claims 8
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 6
- 238000004458 analytical method Methods 0.000 claims 6
- 201000001881 impotence Diseases 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000003085 diluting agent Substances 0.000 claims 5
- 239000003937 drug carrier Substances 0.000 claims 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims 5
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 4
- 239000005557 antagonist Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 238000010171 animal model Methods 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- -1 calcium-activated potassium Chemical class 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000000099 in vitro assay Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0021487.4A GB0021487D0 (en) | 2000-09-01 | 2000-09-01 | Pharmaceutical |
| PCT/IB2001/001525 WO2002017963A2 (en) | 2000-09-01 | 2001-08-24 | Modulators of intermediate conductance calcium-activated potassium (ikca) channel activity for treating sexual dysfunction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004517046A JP2004517046A (ja) | 2004-06-10 |
| JP2004517046A5 true JP2004517046A5 (zh) | 2005-04-07 |
Family
ID=9898666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002522936A Withdrawn JP2004517046A (ja) | 2000-09-01 | 2001-08-24 | 医薬 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1313507A2 (zh) |
| JP (1) | JP2004517046A (zh) |
| AU (1) | AU2001282377A1 (zh) |
| CA (1) | CA2420852A1 (zh) |
| GB (1) | GB0021487D0 (zh) |
| WO (1) | WO2002017963A2 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7258850B2 (en) * | 1999-05-04 | 2007-08-21 | Aradigm Corporation | Methods and compositions for treating erectile dysfunction |
| NO20031157L (no) * | 2002-03-18 | 2003-09-19 | Jenapharm Gmbh | Fremgangsmåte for å identifisere en farmasöytisk aktiv forbindelse for behandling av en tilstand forårsaket av forandret ekspresjon avinsulinreseptoren |
| ES2222831B2 (es) * | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de principio activo que comprende un compuesto 2,5-dihidroxibencenosulfonico y un modulador de los canales de k+. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999003882A2 (en) * | 1997-07-15 | 1999-01-28 | Zeneca Limited | Human leukocyte calcium activated potassium channel polypeptide |
| EP1144387A1 (en) * | 1998-12-04 | 2001-10-17 | Neurosearch A/S | New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents |
| US6803375B1 (en) * | 2000-01-06 | 2004-10-12 | The Regents Of The University Of California | Non-peptide inhibition of T-lymphocyte activation and therapies related thereto |
| EP1251840A2 (en) * | 2000-01-26 | 2002-10-30 | Cedars-Sinai Medical Center | Method for using potassium channel activation for delivering a medicant to an abnormal brain region and/or a malignant tumor |
-
2000
- 2000-09-01 GB GBGB0021487.4A patent/GB0021487D0/en not_active Ceased
-
2001
- 2001-08-24 JP JP2002522936A patent/JP2004517046A/ja not_active Withdrawn
- 2001-08-24 CA CA002420852A patent/CA2420852A1/en not_active Abandoned
- 2001-08-24 EP EP01960993A patent/EP1313507A2/en not_active Withdrawn
- 2001-08-24 WO PCT/IB2001/001525 patent/WO2002017963A2/en not_active Application Discontinuation
- 2001-08-24 AU AU2001282377A patent/AU2001282377A1/en not_active Abandoned
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