JP2004505930A5 - - Google Patents
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- Publication number
- JP2004505930A5 JP2004505930A5 JP2002517100A JP2002517100A JP2004505930A5 JP 2004505930 A5 JP2004505930 A5 JP 2004505930A5 JP 2002517100 A JP2002517100 A JP 2002517100A JP 2002517100 A JP2002517100 A JP 2002517100A JP 2004505930 A5 JP2004505930 A5 JP 2004505930A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- mammal
- composition according
- methyl
- daily
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 67
- 238000000034 method Methods 0.000 claims 60
- 150000003839 salts Chemical class 0.000 claims 42
- 241000124008 Mammalia Species 0.000 claims 38
- 239000012458 free base Substances 0.000 claims 23
- 238000012423 maintenance Methods 0.000 claims 23
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 22
- 239000003814 drug Substances 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 238000011282 treatment Methods 0.000 claims 14
- -1 butyl-4-piperidinyl Chemical group 0.000 claims 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 13
- 230000002265 prevention Effects 0.000 claims 11
- 230000001746 atrial effect Effects 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 9
- 238000013194 cardioversion Methods 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000003523 serotonin 4 antagonist Substances 0.000 claims 7
- 239000003937 drug carrier Substances 0.000 claims 6
- 208000032845 Atrial Remodeling Diseases 0.000 claims 5
- 230000002085 persistent effect Effects 0.000 claims 5
- 230000033764 rhythmic process Effects 0.000 claims 5
- 230000002763 arrhythmic effect Effects 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 4
- 230000037024 effective refractory period Effects 0.000 claims 4
- 206010003130 Arrhythmia supraventricular Diseases 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 230000005764 inhibitory process Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000007911 parenteral administration Methods 0.000 claims 3
- PQJNVHWSTANYGF-UHFFFAOYSA-N 5-amino-n-(1-butylpiperidin-4-yl)-6-chloro-3-methyl-2,3-dihydro-1,4-benzodioxine-8-carboxamide Chemical compound C1CN(CCCC)CCC1NC(=O)C1=CC(Cl)=C(N)C2=C1OCC(C)O2 PQJNVHWSTANYGF-UHFFFAOYSA-N 0.000 claims 2
- MOZPSIXKYJUTKI-UHFFFAOYSA-N GR 113808 Chemical compound C12=CC=CC=C2N(C)C=C1C(=O)OCC1CCN(CCNS(C)(=O)=O)CC1 MOZPSIXKYJUTKI-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000001314 paroxysmal effect Effects 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000007831 electrophysiology Effects 0.000 claims 1
- 238000002001 electrophysiology Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 238000004904 shortening Methods 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0019410A GB0019410D0 (en) | 2000-08-07 | 2000-08-07 | Novel use |
| GB0019523A GB0019523D0 (en) | 2000-08-08 | 2000-08-08 | Novel use |
| GB0019524A GB0019524D0 (en) | 2000-08-08 | 2000-08-08 | Novel use |
| GB0118919A GB0118919D0 (en) | 2001-08-02 | 2001-08-02 | Novel use |
| GB0119022A GB0119022D0 (en) | 2001-08-03 | 2001-08-03 | Novel use |
| PCT/GB2001/003544 WO2002011766A2 (en) | 2000-08-07 | 2001-08-07 | Use of 5ht4 receptor antagonists in the manufacture of a medicament for the prophylaxis or treatment of atrial fibrillation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007062210A Division JP2007145869A (ja) | 2000-08-07 | 2007-03-12 | 心房細動の予防または治療のための薬物の製造における５ｈｔ４受容体アンタゴニストの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004505930A JP2004505930A (ja) | 2004-02-26 |
| JP2004505930A5 true JP2004505930A5 (enExample) | 2005-04-21 |
Family
ID=27515972
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002517100A Pending JP2004505930A (ja) | 2000-08-07 | 2001-08-07 | 心房細動の予防または治療のための薬物の製造における５ｈｔ４受容体アンタゴニストの使用 |
| JP2007062210A Pending JP2007145869A (ja) | 2000-08-07 | 2007-03-12 | 心房細動の予防または治療のための薬物の製造における５ｈｔ４受容体アンタゴニストの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007062210A Pending JP2007145869A (ja) | 2000-08-07 | 2007-03-12 | 心房細動の予防または治療のための薬物の製造における５ｈｔ４受容体アンタゴニストの使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20050032866A1 (enExample) |
| EP (1) | EP1311295A2 (enExample) |
| JP (2) | JP2004505930A (enExample) |
| KR (1) | KR20030027010A (enExample) |
| CN (1) | CN100413539C (enExample) |
| AU (1) | AU781276B2 (enExample) |
| BR (1) | BR0113073A (enExample) |
| CA (1) | CA2418904A1 (enExample) |
| CZ (1) | CZ2003366A3 (enExample) |
| HU (1) | HUP0303075A3 (enExample) |
| IL (1) | IL154279A0 (enExample) |
| MX (1) | MXPA03001210A (enExample) |
| NO (1) | NO20030588L (enExample) |
| NZ (1) | NZ524108A (enExample) |
| PL (1) | PL365048A1 (enExample) |
| WO (1) | WO2002011766A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04007857A (es) * | 2002-02-14 | 2004-10-15 | Glaxo Group Ltd | Composicion farmaceutica que comprende n-((1-butil -4-piperidinil) metil)-3, 4-dihidro-2h -(1, 3)oxazino (3, 2-a)indol -10-carboxamida o sal de la misma, y procedimiento para la misma que comprende granulacion en seco. |
| GB0211230D0 (en) * | 2002-05-16 | 2002-06-26 | Medinnova Sf | Treatment of heart failure |
| EP2366431A1 (en) * | 2010-03-19 | 2011-09-21 | Universitätsklinikum Hamburg-Eppendorf | Myeloperoxidase as a target in atrial fibrillation |
| EP3176164B1 (en) | 2014-07-30 | 2019-08-21 | Aetas Pharma Co. Ltd. | Optical isomer of 1,4-benzothiazepine-1-oxide derivative, and pharmaceutical composition prepared using same |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9009389D0 (en) * | 1990-04-26 | 1990-06-20 | Smith Kline French Lab | Treatment |
| GB9103862D0 (en) * | 1991-02-25 | 1991-04-10 | Glaxo Group Ltd | Chemical compounds |
| CA2118812C (en) * | 1991-09-12 | 2006-01-17 | Francis David King | 5-ht4 receptor antagonists |
| MA22647A1 (fr) * | 1991-09-14 | 1993-04-01 | Smithkline Beecham Plc | Procede de preparation d'un ester ou d'un amide d'un nouveau produit . |
| US5998409A (en) * | 1992-03-12 | 1999-12-07 | Smithkline Beecham Plc | Condensed indole derivatives as 5HT4 -receptor antagonists |
| DE69325167T2 (de) * | 1992-03-12 | 2000-01-20 | Smithkline Beecham P.L.C., Brentford | Kondensierte indol-derivate als 5-ht4-rezeptor-antagonisten |
| US5852014A (en) * | 1992-03-12 | 1998-12-22 | Smithkline Beecham P.L.C. | Condensed indole derivatives as 5HT4 -receptor antagonists |
| GB9206989D0 (en) * | 1992-03-31 | 1992-05-13 | Glaxo Group Ltd | Chemical compounds |
| MX9301837A (es) * | 1992-03-31 | 1994-02-28 | Glaxo Group Ltd | Ureas y fenilcarbamatos substituidos, proceso para su preparacion y composicion farmaceutica que los comprende. |
| SK116394A3 (en) * | 1992-03-31 | 1995-04-12 | Glaxo Group Ltd | Substituted phenylcarbamates and ureas |
| ATE171446T1 (de) * | 1993-05-26 | 1998-10-15 | Syntex Inc | 1-phenylalkanone als 5-ht4 rezeptor ligande |
| IL117438A (en) * | 1995-03-16 | 2001-12-23 | Lilly Co Eli | Indazolecarboxamides, their preparation and pharmaceutical compositions containing them |
| ES2151743T3 (es) * | 1996-08-16 | 2001-01-01 | Smithkline Beecham Plc | Procedimiento para la preparacion de n-((1-n-butil-4-piperidinil)metil)-3,4-dihidro-2h-(1,3)-oxazino(3,2-a)indol-10-carboxamida y las sales y productos intermedios en el procedimiento. |
| NZ535261A (en) * | 2000-08-08 | 2004-12-24 | Smithkline Beecham P | A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide |
-
2001
- 2001-08-07 MX MXPA03001210A patent/MXPA03001210A/es unknown
- 2001-08-07 CZ CZ2003366A patent/CZ2003366A3/cs unknown
- 2001-08-07 AU AU76529/01A patent/AU781276B2/en not_active Ceased
- 2001-08-07 US US10/344,075 patent/US20050032866A1/en not_active Abandoned
- 2001-08-07 CA CA002418904A patent/CA2418904A1/en not_active Abandoned
- 2001-08-07 BR BR0113073-0A patent/BR0113073A/pt not_active IP Right Cessation
- 2001-08-07 JP JP2002517100A patent/JP2004505930A/ja active Pending
- 2001-08-07 NZ NZ524108A patent/NZ524108A/en unknown
- 2001-08-07 CN CNB018169511A patent/CN100413539C/zh not_active Expired - Fee Related
- 2001-08-07 IL IL15427901A patent/IL154279A0/xx unknown
- 2001-08-07 KR KR10-2003-7001797A patent/KR20030027010A/ko not_active Ceased
- 2001-08-07 PL PL01365048A patent/PL365048A1/xx unknown
- 2001-08-07 EP EP01954184A patent/EP1311295A2/en not_active Withdrawn
- 2001-08-07 HU HU0303075A patent/HUP0303075A3/hu unknown
- 2001-08-07 WO PCT/GB2001/003544 patent/WO2002011766A2/en not_active Ceased
-
2003
- 2003-02-06 NO NO20030588A patent/NO20030588L/no not_active Application Discontinuation
-
2006
- 2006-09-20 US US11/533,542 patent/US20070015769A1/en not_active Abandoned
-
2007
- 2007-03-12 JP JP2007062210A patent/JP2007145869A/ja active Pending
- 2007-10-31 US US11/930,277 patent/US20080125422A1/en not_active Abandoned
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