JP2004500088A5 - - Google Patents

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Publication number
JP2004500088A5
JP2004500088A5 JP2001558466A JP2001558466A JP2004500088A5 JP 2004500088 A5 JP2004500088 A5 JP 2004500088A5 JP 2001558466 A JP2001558466 A JP 2001558466A JP 2001558466 A JP2001558466 A JP 2001558466A JP 2004500088 A5 JP2004500088 A5 JP 2004500088A5
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JP
Japan
Prior art keywords
polypeptide
variant
cell epitope
interest
protein
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2001558466A
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English (en)
Japanese (ja)
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JP5112587B2 (ja
JP2004500088A (ja
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Priority claimed from US09/500,135 external-priority patent/US6838269B1/en
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Publication of JP2004500088A publication Critical patent/JP2004500088A/ja
Publication of JP2004500088A5 publication Critical patent/JP2004500088A5/ja
Application granted granted Critical
Publication of JP5112587B2 publication Critical patent/JP5112587B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2001558466A 2000-02-08 2001-01-22 改変された免疫原性応答を生み出す蛋白質およびその作製および使用法 Expired - Fee Related JP5112587B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/500,135 US6838269B1 (en) 1998-04-15 2000-02-08 Proteins producing an altered immunogenic response and methods of making and using the same
US09/500,135 2000-02-08
PCT/US2001/002204 WO2001059130A2 (en) 2000-02-08 2001-01-22 Proteins producing an altered immunogenic response and methods of making and using the same

Publications (3)

Publication Number Publication Date
JP2004500088A JP2004500088A (ja) 2004-01-08
JP2004500088A5 true JP2004500088A5 (https=) 2007-11-08
JP5112587B2 JP5112587B2 (ja) 2013-01-09

Family

ID=23988185

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001558466A Expired - Fee Related JP5112587B2 (ja) 2000-02-08 2001-01-22 改変された免疫原性応答を生み出す蛋白質およびその作製および使用法

Country Status (12)

Country Link
US (1) US6838269B1 (https=)
EP (1) EP1254240B1 (https=)
JP (1) JP5112587B2 (https=)
KR (1) KR20020073582A (https=)
CN (3) CN1418253A (https=)
AR (1) AR027358A1 (https=)
AT (1) ATE355377T1 (https=)
AU (1) AU3651201A (https=)
CA (1) CA2399019A1 (https=)
DE (1) DE60126915T2 (https=)
DK (1) DK1254240T3 (https=)
WO (1) WO2001059130A2 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6967080B1 (en) * 1990-12-05 2005-11-22 Novozymes A/S Proteins with changed epitopes and methods for the production thereof
US6936249B1 (en) * 1998-04-15 2005-08-30 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
CA2249648A1 (en) * 1998-11-04 2000-05-04 Nabil G. Seidah Mammalian subtilisin/kexin isozyme ski-1: a proprotein convertase with a unique cleavage specificity
HUP0402071A2 (hu) * 2001-02-06 2005-01-28 Merck Patent Gmbh. Csökkentett immunogenitású, módosított leptin
JP2005514026A (ja) * 2001-12-31 2005-05-19 ジェネンコー・インターナショナル・インク 免疫反応の変化を生じるプロテアーゼ、ならびにその製造および利用方法
MXPA04006811A (es) * 2002-01-16 2004-10-11 Genencor Int Variantes de proteasa substituidas con multiplos.
US20050239043A1 (en) * 2002-02-26 2005-10-27 Harding Fiona A Subtilisin carlsberg proteins with reduced immunogenicity
WO2004003186A2 (en) * 2002-06-26 2004-01-08 Novozymes A/S Subtilases and subtilase variants having altered immunogenicity
EP2500423B1 (en) * 2003-02-26 2015-06-17 Danisco US Inc. Amylases producing an altered immunogenic response and methods of making and using the same
EP1597363B1 (en) * 2003-02-26 2015-07-15 Danisco US Inc. Amylases producing an altered immunogenic response and methods of making and using the same
PT1861120T (pt) 2005-03-23 2016-08-18 Glaxosmithkline Biologicals Sa Utilização de um vírus influenza e de um adjuvante de emulsão óleo-em-água para induzir células t cd4 e/ou melhorar a resposta de células b de memória
AU2006236905B2 (en) * 2005-04-15 2010-06-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen
HRP20140488T1 (hr) 2006-07-17 2014-07-04 Glaxosmithkline Biologicals S.A. Cjepivo protiv influence
JP5230397B2 (ja) * 2008-12-18 2013-07-10 独立行政法人科学技術振興機構 抗膜貫通型タンパク質抗体の抗原結合部位を決定する方法
ES2594893T3 (es) 2009-12-16 2016-12-23 Abbvie Biotherapeutics Inc. Anticuerpos anti HER2 y sus usos
CN106661566A (zh) 2014-07-04 2017-05-10 诺维信公司 枯草杆菌酶变体以及编码它们的多核苷酸
EP3739029A1 (en) 2014-07-04 2020-11-18 Novozymes A/S Subtilase variants and polynucleotides encoding same
CN109715792A (zh) * 2016-06-03 2019-05-03 诺维信公司 枯草杆菌酶变体和对其进行编码的多核苷酸
WO2026024921A1 (en) * 2024-07-25 2026-01-29 The Procter & Gamble Company Detergent composition comprising a subtilisin variant and methods of use

Family Cites Families (19)

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Publication number Priority date Publication date Assignee Title
DE2926808A1 (de) 1978-07-04 1980-01-17 Novo Industri As Proteaseprodukt mit verringerter allergener wirkung, herstellungsverfahren und waschmittel
US5801038A (en) * 1984-05-29 1998-09-01 Genencor International Inc. Modified subtilisins having amino acid alterations
WO1992010755A1 (en) 1990-12-05 1992-06-25 Novo Nordisk A/S Proteins with changed epitopes and methods for the production thereof
US5593877A (en) * 1993-03-11 1997-01-14 The Rockefeller University Nucleic acid and recombinant production of vespid venom hyaluronidase
DK96493D0 (da) 1993-08-26 1993-08-26 Mouritsen Og Elsner Aps Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden
CU22615A1 (es) 1994-06-30 2000-02-10 Centro Inmunologia Molecular Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
JPH10509324A (ja) 1994-11-24 1998-09-14 ノボ ノルディスク アクティーゼルスカブ 抑制されたアレルゲン性を有するポリペプチドの製造のための方法
US5951980A (en) * 1995-01-06 1999-09-14 Leuven Research & Development Vzw Identification, production and use of new staphylokinase derivatives with reduced immunogenicity
US5837517A (en) * 1995-05-05 1998-11-17 Novo Nordisk A/S Protease variants and compositions
ATE429490T1 (de) 1995-05-05 2009-05-15 Novozymes As Protease-varianten und verbindungen
JP2000506119A (ja) 1996-02-15 2000-05-23 ノボ ノルディスク アクティーゼルスカブ ポリペプチドのコンジュゲーション
US6300116B1 (en) 1996-11-04 2001-10-09 Novozymes A/S Modified protease having improved autoproteolytic stability
WO1998052976A1 (en) 1997-05-21 1998-11-26 Biovation Limited Method for the production of non-immunogenic proteins
AU8595298A (en) 1997-07-29 1999-02-22 The Administrators Of The Tulane Eductional Fund Prediction, detection, and design of t cell epitopes
US6495136B1 (en) * 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
US6835550B1 (en) 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6642011B2 (en) * 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
CA2238660A1 (en) 1998-05-22 1999-11-22 Janet Chantler Gene sequences of rubella virus associated with attenuation
WO2000034317A2 (en) 1998-12-08 2000-06-15 Biovation Limited Method for reducing immunogenicity of proteins

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