JP2004209079A - Chemical injection catheter, and balloon catheter with the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a chemical injection catheter by which the number and height of projections are easily changed, piercing and chemical administration are performed in a plurality of places, and piercing is safely performed even in a thin part such as a blood vessel wall. <P>SOLUTION: Chemical discharge parts (3, 13, 23, 33) are arranged in the middle of main bodies (2, 12, 22, 32), and the sharp projections (7, 17, 27, 37) for discharging chemicals are formed on the side surfaces of the chemical discharge parts (3, 13, 23, 33) in the chemical injection catheters (1, 11, 21, 31). Cylindrical or ring-shaped guide wire insertion parts (4, 14, 24, 34) are mounted on the tip ends of the main bodies (2, 12, 22, 32). <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a PTA catheter used in a percutaneous angioplasty (Percutaneous Transluminal Angioplasty), a catheter used in a PTCA catheter used in a catheter used in a PTCA catheter used in a percutaneous coronary angioplasty (Percutaneous Transluminal Coronary Angioplasty). And a balloon catheter with a drug injection catheter.
[0002]
Problems to be solved by the prior art and the invention
As a treatment for a stenotic blood vessel, percutaneous arterial angioplasty in which a stenosis is dilated using a PTA catheter or a PTCA balloon catheter is performed. In addition, after dilatation with a balloon catheter, stents are routinely placed to prevent restenosis. However, stenosis in the stent occurs even after the stent is placed, which is a problem.
[0003]
Cutting balloon catheters with metal braids on the balloon are used to treat in-stent restenosis, but these catheters are special catheters designed for use with hard lesions, and are not versatile and therefore expensive. It is. Also, a coated stent in which the surface of the stent is coated with a drug is being developed, but there are problems such as the amount of the drug to be coated and the amount of the released drug, and the stent has not yet been put to practical use.
[0004]
For example, Patent Literature 1 describes a vascular drug infusion catheter that can reliably inject a drug or the like by bringing the tip of an introduction needle into close contact with a lesion site on a vessel wall.
The drug injection catheter includes a shaft 2 and an introduction needle 11 detachable from the shaft 2.
The shaft 2 is formed of a shaft main body 2H having a device introduction lumen 3 for inserting the introduction needle 11 and a front shaft 2F having a guide lumen 4L for inserting the guide wire GW. The front shaft 2F and the shaft main body 2H are formed of a guide wall. 5, a side hole 6 is formed in the shaft main body 2H near the guide wall 5, and an opening 9 is formed in the front shaft 2F on the side opposite to the side hole 6.
The introduction needle 11 is formed of a needle part 12 having a bent tip and a connector 10b.
The wall 5a of the guide wall 5 has a shape such that when the introduction needle 11 is inserted into the device introduction lumen 3 and pushed forward, the tip of the needle portion 12 of the introduction needle 11 abuts and can protrude from the side hole 6. And an extension portion is arranged on the opposite side of the side hole 6 of the device introduction lumen 3. When the extension portion is expanded, the tip of the needle portion 12 of the introduction needle 11 protruding from the side hole 6 becomes a pulse. It is formed so that a medicine or the like can be locally injected by being pressed against the tube wall.
Patent Literature 2 discloses an invention in which a puncture member having a sharp tip is fed out of a side hole of a shaft tube of a catheter to a vascular wall to inject a medicine.
However, the inventions described in Patent Literature 1 and Patent Literature 2 require a dedicated shaft tube for guiding the puncture member, and the device becomes large in a thin and highly bent blood vessel located deep in the body such as a coronary artery. And it is difficult to control the puncture member, and the puncture is performed at the tip of the puncture member, so that the number of puncture points is one, and it is difficult to adjust the puncture depth. .
[0005]
[Patent Document 1]
JP 2001-299927 A (FIG. 3)
[Patent Document 2]
Japanese Patent No. 3042299 (FIG. 4)
[0006]
[Means for Solving the Problems]
The inventor of the present invention has made intensive studies in order to solve the above-mentioned problems, and as a result, has reached the following invention.
[1] In the present invention, a medicine release section (3, 13, 23, 33) is arranged in the middle of the main body (2, 12, 22, 32), and the medicine release section (3, 13, 23, 33) is provided. The present invention provides a drug infusion catheter (1, 11, 21, 31) in which sharp projections (7, 17, 27, 37) for drug release are formed on side surfaces of the drug infusion catheter.
[2] The present invention provides the drug infusion catheter according to [1], wherein a cylindrical or ring-shaped guide wire insertion portion (4, 14, 24, 34) is attached to the tip of the main body (2, 12, 22, 32). (1, 11, 21, 31).
[3] The present invention provides the drug infusion catheter (1, 11, 21) according to [1] or [2], wherein a sleeve (35) for protecting the drug release section (3, 13, 23, 33) is mounted. , 31).
[4] The drug according to any one of [1] to [3], wherein the imaging marker (36) is attached to the main body (2, 12, 22, 32) and the drug release unit (3, 13, 23, 33). An infusion catheter (1, 11, 21, 31) is provided.
[5] In the present invention, the main body (2, 12, 22, 32), the guide wire insertion section (4, 14, 24, 34), and the drug release section (3, 13, 23, 33) are formed of metal. A drug injection catheter (1, 11, 21, 31) according to any one of [1] to [4] is provided.
[6] The present invention provides the drug injection catheter according to any one of [1] to [5], wherein a plurality of projections (7, 17, 27, 37) are formed on side surfaces of the drug release portions (3, 13, 23, 33). (1, 11, 21, 31).
[7] In the present invention, a guide wire GW is inserted into a balloon (52, 62) and a shaft tube (53, 63), and the drug injection catheter (1, 11, 21, 31) A balloon catheter (51, 61) with a drug injection catheter in which the drug release section (3, 13, 23, 33) of (31) is mounted on a balloon (52, 62).
[0007]
DETAILED DESCRIPTION OF THE INVENTION
FIGS. 1 to 4 are schematic views showing an example of the drug injection catheter of the present invention, FIGS. 5 and 6 are schematic views showing examples of the balloon catheters 51 and 61 with the drug injection catheter of the present invention, and FIG. It is an expanded sectional view of 3,13,23,33.
[Basic structure]
The drug injection catheters 1, 11, 21, and 31 of the present invention include guide wire insertion portions 4, 14, 24, 34 at the distal ends of the main bodies 2, 12, 22, 32, and drug injection portions 3, 13, 23, 33 at the front. , And the rear end is equipped with an injection hub 8, 18, 28, 38, respectively.
[0008]
[Body 2, 12, 22, 32]
The main body (also referred to as an injection tube) 2, 12, 22, 32 preferably has a high pressure resistance and a high torque property, and a plastic tube or a metal tube containing a blade used for an angiography catheter is used. Is good.
The portion connecting the distal end portions of the main bodies 2, 12, 22, 32 and the drug release portions 3, 13, 23, 33 is preferably formed as flexible as a guide wire so as not to damage blood vessels. For example, by forming a material having a greater elasticity or a smaller diameter on the distal end side than on the proximal end side.
[Drug release units 3, 13, 23, 33]
As shown in FIG. 7, the drug release portions 3, 13, 23, and 33 have sharp protrusions 7, 17, 27, and 37 for drug release protruding from side surfaces thereof. Is released.
(A) shows an example in which the protrusions 7, 17, 27, and 37 are formed at one place, and (B) shows an example in which the protrusions 7, 17, 27, and 37 are formed at two places.
The projections 7, 17, 27, 37 are formed of hard plastic or metal so that they can puncture the blood vessel wall.
The drug release sections 3, 13, 23, and 33 are provided with a medical solution (drug) from the injection hubs 8, 18, 28, and 38, through the main bodies 2, 12, 22, 32, and the projections 7, 17, 27, and 37, and through the vascular wall. A liquid passage 9 is formed as shown in FIG.
The projections 7, 17, 27, and 37 are formed so as to be sharp so that the tip of the nozzle can puncture the blood vessel wall. The number, height, shape, etc. of the projections can be freely changed according to the purpose of treatment. It is preferable to form a plurality of protrusions rather than one.
[0009]
[Guide wire insertion parts 4, 14, 24, 34]
At the distal end of the main body 2, 12, 22, 32, the guide wire insertion part 4, so that the main body 2, 12, 22, 32 can be inserted along the guide wire GW already inserted into the balloon catheters 51, 61, 14, 24, 34 are attached. As the guide wire insertion portions 4, 14, 24, 34, a cylindrical pipe made of metal or synthetic resin (FIG. 3), or an elliptical (FIG. 1) or perfect circular (FIG. 2) ring is preferably used.
These guide wire insertion portions 4, 14, 24, 34 are preferably formed in a shape that allows a plurality of guide wire insertion portions 4, 14, 24, 34 to be connected.
[Sleeve 35]
A sleeve 35 is attached so as to cover the drug release portions 3, 13, 23, 33 so as not to damage the blood vessel wall and the balloon catheters 52, 62 until the drug release portions 3, 13, 23, 33 reach the lesion. However, it is also possible to remove the sleeve 35 when the balloons 52, 62 are inflated to expose the drug release portions 3, 13, 23, 33.
[0010]
[Contrast marker 36]
Further, a contrast marker 36 may be attached to the main bodies 2, 12, 32, 33 and the drug release sections 3, 13, 23, 33. By attaching the contrast marker 36 to the tips of the main bodies 2, 12, 22, 32 and to the vicinity of the protrusions 7, 17, 27, 37 of the drug release sections 3, 13, 23, 33, the main bodies 2, 12, 22, 32 It is possible to accurately know the positions of the medicine release units 3, 13, 23, and 33.
[0011]
[Balloon catheters 51 and 61]
In the balloon catheters 51, 61 of the present invention, the guide wires GW are inserted into the balloons 52, 62 and the shaft tubes 53, 63, and the drug release portions 3, 13, 23, 33 of the guide wires 1, 11, 21, 31 are inserted. Are mounted on the balloons 52 and 62.
As shown in FIG. 5, one drug injection catheter 1, 11, 21, 31 and, if necessary, two (multiple) drug injection catheters 1, 11, 21, 31 as shown in FIG. 6 can be used simultaneously. I have to.
The drug injection catheters 1, 11, 21 and 31 of the present invention are located outside the balloons 52 and 62 of the balloon catheters 51 and 61, and expand the balloons 52 and 62, so that the sharp drug release portions 3, 13, and 23 are formed. , 33 are punctured into the blood vessel wall and the drug is injected from the hubs 8, 18, 28, 38 through the main bodies 2, 12, 22, 32, the projections 7, 17, 27, 37, and the drug solution (drug) is injected into the blood vessel wall. Can be injected.
[0012]
Effects of the Invention
(1) Since the drug injection catheter of the present invention does not require a dedicated guiding catheter (shaft tube), it can easily reach the target site through the guide wire, and the protrusion of the drug release portion is provided in the side direction. In addition, the number and height of the projections can be easily changed, and the use of a plurality of drug injection catheters of the present invention enables simultaneous puncturing and drug administration at a plurality of locations. In addition, since the height of the projection is the puncturing depth, it is possible to safely puncture a thin portion such as a blood vessel wall.
(2) In order to prevent restenosis in the stent, in the case of expansion, use of an expensive cutting balloon catheter or a coated stent coated with a drug has been studied, but the drug injection catheter of the present invention is mounted on the balloon catheter. As a result, the drug can be directly injected into the blood vessel wall, and a more effective treatment can be performed. In addition, a gene or the like can be introduced locally, and a new treatment can be developed.
[Brief description of the drawings]
FIG. 1 is a schematic diagram showing an example of a drug injection catheter of the present invention. FIG. 2 is a schematic diagram showing an example of a drug injection catheter of the present invention. FIG. 3 is a schematic diagram showing an example of a drug injection catheter of the present invention. 4 is a schematic view showing an example of the drug injection catheter of the present invention. FIG. 5 is a schematic view showing an example of a balloon catheter with the drug injection catheter of the present invention. FIG. FIG. 7 is a schematic view showing an example of a balloon catheter. FIG. 7 is an enlarged cross-sectional view of the drug release sections 3, 13, 23, and 33.
1, 11, 21, 31 Drug infusion catheter 2, 12, 22, 32 Main body 3, 13, 23, 33 Drug release part 4, 14, 24, 34 Guide wire insertion part 35 Sleeve 36 Contrast marker 7, 17, 27, 37 Projection 8, 18, 28, 38 Injection hub 9 Liquid passage 51, 61 Balloon catheter 52, 62 Balloon 53, 63 with drug injection catheter Shaft tube GW Guide wire

Claims (7)

A drug release section (3, 13, 23, 33) is arranged in the middle of the main body (2, 12, 22, 32), and a side for drug release is provided on a side surface of the drug release section (3, 13, 23, 33). A drug injection catheter (1, 11, 21, 31) characterized in that sharp projections (7, 17, 27, 37) are formed. The drug injection catheter (1) according to claim 1, characterized in that a cylindrical or ring-shaped guide wire insertion portion (4, 14, 24, 34) is attached to a distal end of the main body (2, 12, 22, 32). , 11, 21, 31). The drug injection catheter (1, 11, 21, 31) according to claim 1 or 2, further comprising a sleeve (35) for protecting the drug release portion (3, 13, 23, 33). ). 4. A drug injection catheter according to claim 1, wherein a contrast marker (36) is mounted on the main body (2, 12, 22, 32) and the drug release section (3, 13, 23, 33). (1, 11, 21, 31). The said main body (2,12,22,32), the guide wire insertion part (4,14,24,34), and the medicine discharge part (3,13,23,33) were formed with metal. The drug injection catheter (1, 11, 21, 31) according to any one of claims 1 to 4. The drug injection catheter (1) according to claim 1, wherein a plurality of projections (7, 17, 27, 37) are formed on side surfaces of the drug release portion (3, 13, 23, 33). , 11, 21, 31). A guide wire (GW) is inserted into the balloon (52, 62) and the shaft tube (53, 63), and the drug release section (1, 11, 21, 31) of the drug injection catheter (1, 11, 21, 31) according to claim 1 to 6. 3, 13, 23, 33) attached to a balloon (52, 62).

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