JP2004159863A - Sterilizing method for opening part of connected sterile apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a sterilizing method for an opening part of a connected sterile apparatus removing non-sterilized region formed in a close contact part between a pressure contact end of a packing and its opposed surface. <P>SOLUTION: A first expansive packing 15 and a second expansive packing 16 are provided inside/outside circumferential edges of the opening part 6, an opening/closing door 10 is firmly closed, the inside first expansive packing 15 out of the first expansive packing 15 and the second expansive packing 16 is pressurized, its pressure contact end x1 and an opening/closing door surface (y) are closely contacted, the outside second expansive packing 16 is decompressed and its pressure contact end x2 and the opening/closing door surface (y) are separated. Hydrogen peroxide gas g1 is inputted in a storage 11 of an isolator 1. The hydrogen peroxide gas g1 is emitted after the lapse of a prescribed time. Then, the second expansive packing 16 is pressurized, the pressure contact end x2 is closely contacted with the opening/closing door surface (y), the first expansive packing 15 is decompressed this time and its pressure contact end x1 is separated from the opening/closing door surface (y). Steam sterilizing gas g2 is inputted in the storage 12 of a steam sterilizing device 2 and the steam sterilizing gas g2 is sucked after the lapse of a prescribed time. <P>COPYRIGHT: (C)2004,JPO

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a continuous aseptic device in which sterile devices such as an isolator device constituting a local clean space are connected to each other, and more particularly, to a method of sterilizing an opening formed for communicating each sterile device. Things.
[0002]
[Prior art]
BACKGROUND ART Aseptic devices such as an isolator device, a steam sterilizing device, and a freeze-drying device that seal the inside of a refrigerator and maintain a sterile and dust-free condition in the refrigerator are well known. Furthermore, for example, an isolator device and a steam sterilization device are connected so that the inside of each compartment communicates with each other, and a workpiece processed in a local clean space inside the compartment of the isolator device is kept in a sterile and dust-free state while maintaining a sterile and dust-free state. There is also proposed a configuration in which the sheet is conveyed to a vehicle. In this configuration, the isolator device and the steam sterilizer are connected in series with the openings formed in each device housing facing each other, and the interior of each device is maintained in a sterile and dust-free state by both openings. So that they can communicate.
[0003]
By the way, there is a case where it is desired to sterilize the inside of each of the devices connected in series as described above using different sterilizing gases (including pressurized steam or the like). In such a case, the opening and closing door arranged in the storage of any of the devices, the opening is closed and the inside of the storage is shut off, for example, the isolator device is sterilized using hydrogen peroxide gas, On the other hand, the steam sterilizer sterilizes using steam gas at a predetermined temperature. In order to prevent the sterilizing gas from leaking into the other unintended chamber, a gasket of a predetermined shape is arranged between the closed door and the periphery of the opening. The first aseptic device and the second aseptic device are sealed by closing the gap between the opening and closing door and the opening by bringing the first and second aseptic devices into close contact with each other (see, for example, Patent Document 1).
[0004]
[Patent Document 1]
JP 2000-346418 A
[Problems to be solved by the invention]
Here, since the sterilizing gas is supplied in a state where the opening / closing door is closed, the injected sterilizing gas does not come into contact with the press-contact end of the packing and the opposing surface thereof. Will occur. If the opening / closing door is opened in such a situation, it is not possible to complete the sterile and dust-free state in the warehouse as a whole, and the reliability of the sterile device is greatly impaired.
Therefore, an object of the present invention is to provide a method of sterilizing an opening of a continuous aseptic apparatus capable of removing a non-sterile region generated on a press-contact end of a packing and a surface facing the press-contact end.
[0006]
[Means for Solving the Problems]
According to the present invention, the first aseptic device and the second aseptic device are connected to each other with openings formed in respective device housings facing each other, and the interior of each aseptic device is sterilized by both openings. They communicate with each other so that a dust-free state is maintained, and they communicate with each other inside the cabinet of the aseptic device by an opening / closing door provided in either the inside of the first aseptic device or the inside of the second aseptic device. In the continuous aseptic device that converts the state to either the state or the blocking state, a plurality of packings are disposed inside and outside the opening periphery so as to be located between the opening / closing door in the blocking state and the periphery of the opening. Then, the packing control means makes the press contact end of the packing closely contact the opposing surface, seals the first aseptic device and the second aseptic device, separates the press contact end of the packing from the opposing surface, and connects the first aseptic device with the first aseptic device. (2) The aseptic device is not sealed, and the press-contact end is in close contact with the facing surface. The packing in which the aseptic device and the second aseptic device are sealed, once the pressure contact end of any other packing is in close contact with the opposing surface, separated from the opposing surface, and between the pressure contact end of the packing and the opposing surface. A method for sterilizing an opening of a continuous aseptic apparatus in which a packing sterilization step for allowing a sterilizing gas to flow is performed (claim 1).
[0007]
In such a configuration, when the first aseptic device and the second aseptic device are sterilized by separate sterilizing gases, first, the opening and closing doors are closed in advance to seal each aseptic device, and the supplied aseptic gas is intended. It is necessary to prevent leakage into the other storage. For this reason, the press-contact end of the packing is brought into close contact with the opposing surface so that the sterilizing gas does not flow between the press-contact end and the opposing surface. However, the fact that the sterilizing gas does not flow between the press-contact end and the opposing surface means that the contact portion between the press-contact end and the opposing surface loses contact with the sterilizing gas and becomes a non-sterile region. For this reason, in the present invention, the press-contact end of the packing other than the packing which once generated the non-sterile region is brought into close contact with the opposing surface, and then the press-contact end of the packing over the non-sterile region is brought into contact with the opposing surface. Then, the press-contact end, which was initially closely contacted, and the opposing surface are separated from each other, and the non-sterilized area is brought into contact with a new sterilizing gas to sterilize the area afterwards. is there. With this configuration, the opening of the continuous aseptic device can be sterilized without the sterilizing gas leaking into the other unintended chamber.
[0008]
Here, in a configuration in which the two packings are arranged inside and outside the periphery of the opening so as to be located between the opening / closing door and the periphery of the opening, the packing sterilization process includes the packing on the sterilization gas input side. The sterile gas is injected into the aseptic device with the press-contact end of the packing separated from the opposing surface, and the press-contact end of the packing on the other side is in close contact with the opposing surface. After the press-contact end of the packing separated from the surface is in close contact with the opposing surface, the press-contact end of the packing in which the press-contact end is in close contact with the opposing surface is separated from the opposing surface, and sterilized in the chamber of the other aseptic device. A configuration in which gas is supplied is proposed (claim 2).
[0009]
In such a configuration, first, the opening and closing door is closed in advance to shut off the continuous aseptic device, and when sterilizing from the first aseptic device, of the two packings provided, the inside of the first aseptic device storage is used. The press-contact end of the packing is separated from the opposing surface, and the press-contact end of the packing inside the second aseptic device chamber is brought into close contact with the opposing surface to seal each aseptic device. Avoid leaking into the second aseptic equipment compartment. Then, when a necessary and sufficient time for sterilization elapses after the sterilizing gas is charged into the storage of the first sterile apparatus, the sterilizing gas is discharged. Then, the press-contact end of the packing inside the first aseptic device that has been separated first is brought into close contact with the opposing surface, and then the press-contact end of the packing inside the second aseptic device that is initially brought into close contact is separated from the opposing surface. Then, in this state, a different sterilizing gas is newly introduced into the storage of the second aseptic apparatus, and after a predetermined time has elapsed, the sterilizing gas is discharged. With such a configuration, even when the press-contact end of the packing is in close contact with the opposing surface during the sterilization of the first aseptic apparatus and a non-sterile area is generated, the sterile gas does not leak into the other chamber, and the second sterile At the time of device sterilization, the non-sterile region can be sterilized, and the accuracy of the aseptic and dust-free state of the continuous aseptic device is improved.
[0010]
Here, the packing is a moving packing in which the packing main body moves in a direction substantially perpendicular to the opposing surface, and the packing main body moves to the opposing surface side by the protrusion control by the packing control means, so that the press-contact end is in close contact with the opposing surface. Then, a configuration is proposed in which the packing body moves to the opposite side of the facing surface by the retreat control, and the press-contact end is separated from the facing surface (claim 3). By using such a configuration, the opening of the continuous aseptic apparatus can be sterilized without the sterilization gas leaking into the other unintended chamber.
[0011]
Further, when the packing is a hollow expansion / contraction packing and the packing control means controls the pressurization of the inner space of the expansion / contraction packing, the press contact end of the expansion / contraction packing comes into close contact with the opposing surface, and the inner space of the expansion / contraction packing is removed. When pressure reduction control is performed, a configuration is proposed in which the pressure contact end of the expansion / contraction packing is separated from the facing surface (claim 4). Even with such a configuration, the opening of the continuous aseptic device can be sterilized without the sterilizing gas leaking into the other unintended chamber.
[0012]
Further, a negative pressure air suction passage is provided at the periphery of the opening of the device housing, which is a negative pressure with respect to the inside and outside of the sterile device, and a sterilizing gas is injected into any of the sterile devices. At this time, a configuration is proposed in which the inside of the chamber is made to have a positive pressure with respect to the outside, and the sterilizing gas is sucked through a negative pressure air suction passage formed in the apparatus casing of the aseptic apparatus. 5).
[0013]
With such a configuration, sterilizing gas that is going to pass through the inner peripheral edge of the opening due to the positive pressure in the refrigerator is sucked through the negative pressure air suction passage. Therefore, the sterilizing gas easily spreads to the opening where the negative pressure air suction passage is formed, and the inside of the refrigerator can be reliably sterilized. Further, it is preferable that the negative pressure air suction passage is formed between packings. This configuration ensures that the sterilizing gas flows between the press-contact end of the packing and the opposing surface.
[0014]
BEST MODE FOR CARRYING OUT THE INVENTION
An embodiment of the present invention will be described with reference to the accompanying drawings.
1 and 2 show an example of a sterile and dust-free system using the isolator device 1 (sterile device). In this system, a plurality of movable or fixed isolators 1 are used, and processing and the like of a work are performed in a chamber 11 of each isolator 1. Further, a work is exchanged through openings formed in the respective device housings 3, and a series of sequential operations are sequentially performed. Further, the processed work is transferred to the inside 12 of the steam sterilizer 2 (sterile apparatus).
[0015]
Here, in order to transfer the work from the interior 11 of the isolator device 1 to the interior 12 of the steam sterilization device 2, as shown in FIG. 4, openings 5 and 6 are formed. The devices 1 and 2 are connected so that the openings 5 and 6 face each other, so that the insides 11 and 12 of the devices 1 and 2 communicate with each other. Note that the serially provided isolator device 1 and the steam sterilizer 2 constitute a continuous sterile device A according to the present invention.
[0016]
Here, as shown in FIG. 2, the isolator device 1 is provided with a glass window 7 in the device housing 3, and a work glove 9 that enables manual work in a work hole 8 formed in the window glass 7. Is mounted hermetically. Then, a hand can be inserted into the work glove 9 and work can be performed in the interior 11 of the isolator device 1 while checking the work through the glass window 7.
[0017]
On the other hand, the steam sterilization apparatus 2 is for injecting saturated steam of about 130 ° C. into the interior 12 to kill the object to be sterilized.
[0018]
By the way, there are cases where it is desired to sterilize the interior 11 of the isolator device 1 and the interior 12 of the steam sterilizer 2 using different sterilization gases. For this reason, as shown in FIG. 3, an opening / closing door 10 that covers the opening 6 is pivotally installed in the interior 11 of the isolator device 1 to convert the interiors 11 and 12 into either a communicating state or a blocking state. Such a configuration is preferably used.
[0019]
Further, between the open / close door 10 in the closed state and the peripheral edge of the opening 6, two hollow expansion / contraction packings 15, 16 each having a substantially circular cross section are provided inward and outward. More specifically, as shown in FIG. 5 or FIGS. 6 and 7, packing storage grooves 13 and 14 having a U-shaped cross section are formed on the periphery of the opening 6 formed in the device housing 4 of the steam sterilizer 2. Are formed in two rows concentrically, a first expansion / contraction packing 15 is provided in the inner packing storage groove 13, and a second expansion / contraction packing 16 is provided in the outer packing storage groove 14. That is, when the opening / closing door 10 is closed, the first expansion / contraction packing 15 faces the interior 12 of the steam sterilizer 2, whereas the second expansion / contraction packing 16 faces the interior 11 of the isolator device 1. It becomes.
[0020]
Further, the two expansion / contraction packings 15 and 16 are made of an elastic material, and are controlled by a vacuum pump 17 and an air source 18 provided outside the continuous aseptic apparatus A so as to change the internal pressure of the inner space e. Pressure reduction is controlled. When the expansion and contraction packings 15 and 16 are pressurized and controlled by the air source 18, their outer shapes are deformed and their diameters are increased, so that the pressure contact ends x 1 and x 2 of the expansion and contraction packings 15 and 16 and the opening / closing door surface y (opposing). Surface) and the insides 11 and 12 are sealed (see FIGS. 6 and 7). On the other hand, when the pressure is controlled by the vacuum pump 17, the outer shape is deformed and the diameter is reduced, and a gap is generated between the press-contact ends x of the expansion and contraction packings 15, 16 and the door surface y. Here, in the present embodiment, as shown in FIG. 6, a plurality of open / close ports are provided between the expansion / contraction packings 15 and 16 and the negative pressure air suction passage 19 and the vacuum pump 17 and the air source 18. A valve z is provided, and the drive of these on-off valves z is controlled by a central control unit CPU. That is, a desired control form is obtained by drive control of the central control unit CPU. The packing control means according to the present invention is constituted by the central control unit CPU. Further, a HEPA filter 50 is connected between the negative pressure air suction passage 19, the vacuum pump 17 and the air source 18.
[0021]
Further, a negative pressure air suction passage 19 is formed on the periphery of the opening 6 and between the first expansion / contraction packing 15 and the second expansion / contraction packing 16 as shown in FIGS. . One end of the negative pressure air path 19 is opened to the inner wall of the inside 11 of the refrigerator, and the other end of the path is connected to the vacuum pump 17. On the other hand, the pressure is reduced to 5 to 50,000 Pa.
[0022]
The opening and closing door 10 is pivotally supported at one side edge by a hinge member (not shown) provided on the inner wall of the isolator device 1. Further, as shown in FIG. 4, a plurality of collapsible handle-type fixtures 20 are provided around the opening 6, and the head of the handle-type fixture 20 is raised with respect to the inner wall of the refrigerator. Then, the body of the handle fixture 20 is fitted into the notch 22 formed on the peripheral edge of the door 10, and the door 10 is pressed rearward on the back surface of the handle 21 to completely close the door.
[0023]
Next, the main part of the present invention will be described.
In the above-described continuous aseptic apparatus A, the isolator apparatus 1 is sterilized with hydrogen peroxide gas g1, while the steam sterilizer 2 is sterilized with steam sterilization gas g2. .
[0024]
First, the opening / closing door 10 is closed in advance, and the continuous aseptic apparatus A is set in the closed state. Here, when sterilizing from the isolator device 1, as shown in FIG. 6, the inner first expansion / contraction packing 15 of the first expansion / contraction packing 15 and the second expansion / contraction packing 16 is connected to the air source 18. It is driven to a pressurized state, and the press contact end x1 and the opening / closing door surface y are brought into close contact. At the same time, the outer second expansion / contraction packing 16 is driven to a reduced pressure by driving the vacuum pump 17, and the press-contact end x2 is separated from the door surface y. In this way, the insides 11 and 12 of the refrigerator are sealed.
[0025]
From this state, the hydrogen peroxide gas g1 is introduced into the interior 11 of the isolator device 1. Further, the negative pressure air suction passage 19 is set to a negative pressure with respect to the inside 11 and the outside of the isolator device 1, and the inside 11 is set to a positive pressure with respect to the outside, so that the injected hydrogen peroxide gas g1 is set at a negative pressure. The air is sucked in the air suction passage 19. With such a configuration, the hydrogen peroxide gas g <b> 1 charged into the chamber 11 sufficiently spreads to the gap between the opening 6 and the opening / closing door 10, thereby enabling highly accurate sterilization processing.
[0026]
Next, when sufficient time necessary for sterilization has elapsed after the supply of the hydrogen peroxide gas g1, the hydrogen peroxide gas g1 is discharged through a discharge port (not shown) or the negative pressure air suction passage 19.
[0027]
Then, when the hydrogen peroxide gas g1 is completely discharged, as shown in FIG. 7, the second expansion / contraction packing 16 which has been decompressed at the time of sterilization of the isolator device 1 is put in a pressurized state, and its press contact end x2 is opened and closed. Close the door surface y. At the same time, the first expansion / contraction packing 15 which was in a pressurized state at the time of sterilization of the isolator device 1 is now in a depressurized state, and the press contact end x1 is separated from the opening / closing door surface y.
[0028]
Further, in this state, the steam sterilization gas g2 having a predetermined temperature is introduced into the interior 12 of the steam sterilization apparatus 2. Here, similarly to the time of sterilization of the isolator device 1, the negative pressure air suction passage 19 is set to a negative pressure with respect to the inside 12 and the outside of the steam sterilizer 2, and the inside 12 is set to a positive pressure with respect to the outside. Then, the supplied steam sterilization gas g2 is sufficiently distributed to the gap between the opening 6 and the door 10.
[0029]
By the way, at the time of sterilization of the isolator device 1, the first expansion / contraction packing 15 is in a pressurized state, and the press contact end x1 is in close contact with the opening / closing door surface y. It was not in contact with the added hydrogen gas g1 and was in a non-sterile region. However, at the time of sterilization of the steam sterilizer 2, the expansion and contraction packings 15 and 16 as described above are controlled so that the steam sterilization gas g2 flows between the press-contact end x1 and the door surface y (packing sterilization step). Thus, the non-sterile region can be sterilized.
[0030]
Then, after a lapse of a predetermined time, the steam sterilization gas g2 is discharged, and a series of sterilization processing of the continuous aseptic apparatus A is completed.
[0031]
Further, instead of the structure using the expansion and contraction packings 15 and 16 described above, a structure using a moving packing 30 as shown in FIG. The movable packing 30 includes a packing main body 33, a support portion 31, and a stopper 32, and has a cylindrical support portion 31 inserted through an insertion hole 34 formed in the bottom of the packing storage groove 13 (14). By reciprocating in a direction substantially perpendicular to the opposing surface y, the press-contact end x3 of the packing body 33 connected to the opposing surface side end of the support portion 31 comes into close contact with the opposing surface y or separates from the opposing surface y. Is converted to The other end of the support portion 31 is connected to a stopper 32 that limits the moving distance of the packing body 33 and has a diameter larger than the insertion hole 34. The moving packing 30 having such a configuration is connected to the central control unit CPU, and the packing main body 33 moves to the facing surface y side by the protrusion control of the central controlling unit CPU so that the press contact end x3 comes into close contact with the facing surface y. Then, the evacuation control moves the packing body 33 to the opposite side of the opposing surface y, and the press contact end x3 is separated from the opposing surface y. That is, a desired control form is obtained by drive control of the central control unit CPU.
[0032]
In addition, besides the isolator device 1 and the steam sterilization device 2, examples of the aseptic device include a freeze-drying device, a dry heat sterilization device, an EOG sterilization device, and a hydrogen peroxide gas sterilization device. Various combinations can be proposed instead of the above-described configuration.
[0033]
Of course, any one of the two sterile devices constituting the continuous aseptic device A may be sterilized. Further, any number of expansion / contraction packings may be provided as long as they are plural. Also, various configurations of the packing have been proposed, and any structure can be used as long as the pressure-contact end of the packing can be closely contacted with the opposing surface and the pressure-contact end of the packing can be separated from the opposing surface.
[0034]
【The invention's effect】
The present invention provides a packing in which the press-contact end is in close contact with the opposing surface to seal the first aseptic device and the second aseptic device, and once the press-contact end of any other packing is in close contact with the opposing surface, Since the packing is sterilized by separating the gasket from the surface and allowing the sterilizing gas to flow between the press-contact end of the packing and the opposing surface (claim 1), the non-sealing caused by the packing coming into close contact with the opposing surface. The sterilization area can be sterilized afterwards, the area to be sterilized is removed, and an excellent effect of improving the accuracy of the aseptic and dust-free state of the continuous aseptic apparatus is produced.
[0035]
Further, in the packing sterilization step, the sterilization gas is injected into the storage of the aseptic apparatus by separating the press-contact end of the packing on the sterilization gas input side from the opposing surface, and bringing the press-contact end of the other packing into close contact with the opposing surface. After the sterilizing gas is discharged, once the press-contact end of the packing whose press-contact end is separated from the opposing surface is in close contact with the opposing surface, the press-contact end of the packing in which the press-contact end is closely contacted with the opposing surface is from the opposing surface. In a case where the sterile gas is introduced into the storage of the other aseptic device at a distance (claim 2), even when the first aseptic device is sterilized, the pressure contact end of the packing comes into close contact with the facing surface. Even if a non-sterilized area is generated, it is possible to sterilize the non-sterile area at the time of sterilization of the second aseptic apparatus, and the area to be sterilized is removed, and other sterilizing gas leaks into an unintended chamber. The aseptic and sterility of the continuous aseptic device without Excellent effect occurs can improve the state accuracy.
[0036]
When the packing is a movable packing (claim 3), the opening of the continuous aseptic apparatus can be suitably sterilized without leaking the sterilizing gas into the other unintended chamber.
[0037]
Also, by using the packing as the expansion and contraction packing (claim 4), it is possible to preferably sterilize the opening of the continuous aseptic apparatus without leaking the sterilizing gas into the other unintended chamber.
[0038]
Further, when the sterilizing gas is introduced into the chamber of any one of the aseptic apparatuses, the inside of the chamber is made to have a positive pressure with respect to the outside, and a negative pressure air suction passage formed in the apparatus housing of the aseptic apparatus. In the case where the sterilizing gas is sucked (claim 5), the sterilizing gas which is going to pass through the inner peripheral edge of the opening due to the positive pressure in the refrigerator is sucked through the negative pressure air suction passage. This has the advantage that the sterilizing gas easily spreads to the opening where the negative pressure air suction passage is formed, and the interior of the refrigerator can be reliably sterilized.
[0039]
[Brief description of the drawings]
FIG. 1 is a schematic side view of a sterile and dust-free system to which the present invention is applied.
FIG. 2 is a schematic plan view of a sterile and dust-free system to which the present invention is applied.
FIG. 3 is a cross-sectional view of the continuous aseptic device A.
4 is a front view of the door 10. FIG.
FIG. 5 is a front view of an opening 6 around which a first expansion / contraction packing 15 and a second expansion / contraction packing 16 are provided.
FIG. 6 is a schematic plan view showing a first expansion / contraction packing 15 in a pressurized state and a second expansion / contraction packing 16 in a depressurized state.
FIG. 7 is a schematic plan view showing a first expansion / contraction packing 15 in a reduced pressure state and a second expansion / contraction packing 16 in a reduced pressure state.
8A is a schematic plan view showing a state in which the movable packing 30 is controlled to retreat, and FIG. 8B is a schematic plan view showing a state in which the movable packing 30 is controlled to protrude.
[Explanation of symbols]
A Continuous aseptic device x1, x2, x3 Pressing end facing surface y
DESCRIPTION OF SYMBOLS 1 Isolator apparatus 2 Steam sterilizer 3, 4 Device housing 5, 6 Opening 10 Opening / closing door 11, 12 Inside 15 First expansion / contraction packing 16 Second expansion / contraction packing 19 Negative pressure air suction passage 30 Moving packing 33 Packing main body

Claims (5)

The first aseptic device and the second aseptic device are connected in series with the openings formed in the respective device housings facing each other, and the interior of each aseptic device is kept in a sterile / dust-free state by both openings. While communicating with each other so as to be maintained, the open / close door provided in either the first aseptic device compartment or the second aseptic device compartment allows the inside of the aseptic device to communicate with each other or to be in a closed state. In the continuous aseptic device to convert to any of
A plurality of packings are arranged inside and outside the opening periphery so as to be located between the opening / closing door in the closed state and the opening periphery, and the pressure control end of the packing is brought into close contact with the opposing surface by the packing control means. The first aseptic device and the second aseptic device are sealed, the press-contact end of the packing is separated from the opposing surface, the first aseptic device and the second aseptic device are unsealed, and the press-contact end is in close contact with the opposing surface. Once the packing in which the first aseptic device and the second aseptic device are hermetically sealed, once the pressure-contact end of any other packing is brought into close contact with the opposing surface, the packing is separated from the opposing surface, and the packing is opposed to the pressure-contact end of the packing. A method of sterilizing an opening of a continuous aseptic apparatus, wherein a packing sterilization step for allowing a sterilizing gas to flow between surfaces is performed. In a configuration in which two packings are arranged inside and outside the opening periphery so as to be located between the opening / closing door in the closed state and the opening periphery,
In the packing sterilization step, the press-contact end of the packing on the sterilization gas input side is separated from the opposing surface, and the press-contact end of the packing on the other side is brought into close contact with the opposing surface, and the sterilization gas is supplied into the storage of the aseptic apparatus. After the sterilizing gas is discharged, once the press-contact end of the packing whose press-contact end is separated from the opposing surface is closely contacted with the opposing surface, the press-contact end of the packing whose press-contact end is closely contacted with the opposing surface is separated from the opposing surface. 2. The method for sterilizing an opening of a continuous aseptic apparatus according to claim 1, wherein a sterilizing gas is introduced into the storage of the other aseptic apparatus. The packing is a moving packing in which the packing body moves in a direction substantially perpendicular to the facing surface,
The packing body moves to the opposing surface side by the protrusion control by the packing control means, and the press contact end comes into close contact with the opposing surface, and the retraction control moves the packing body to the opposite side of the opposing surface, and the press contact end separates from the opposing surface. The method for sterilizing an opening of a continuous aseptic apparatus according to claim 1 or 2, wherein: The packing is a hollow expansion-contraction packing,
When the packing control means controls the pressurization of the inner space of the expansion / contraction packing, the pressure contact end of the expansion / contraction packing comes into close contact with the opposing surface, and when the pressure inside the expansion / contraction packing is controlled to reduce the pressure, the pressure contact end of the expansion / contraction packing moves from the opposing surface. 3. The method for sterilizing an opening of a continuous aseptic apparatus according to claim 1, wherein the method is separated. At the periphery of the opening of the device housing, while forming a negative pressure air suction path that becomes a negative pressure for the inside and outside of the sterile device,
When the sterilizing gas is charged into the chamber of the aseptic apparatus, the inside of the chamber is set to a positive pressure with respect to the outside, and the sterilizing gas injected through the negative pressure air suction passage formed in the apparatus casing of the aseptic apparatus is used. The method for sterilizing an opening of a continuous aseptic apparatus according to any one of claims 1 to 4, wherein suction is performed.

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