JP2004121857A - Carrier for blood component absorption and its production method - Google Patents

Carrier for blood component absorption and its production method Download PDF

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JP2004121857A
JP2004121857A JP2003358991A JP2003358991A JP2004121857A JP 2004121857 A JP2004121857 A JP 2004121857A JP 2003358991 A JP2003358991 A JP 2003358991A JP 2003358991 A JP2003358991 A JP 2003358991A JP 2004121857 A JP2004121857 A JP 2004121857A
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carrier
spherical
outer layer
molded
spherical molded
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JP3952406B2 (en
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Takuya Wada
和田 拓也
Masahiro Nakaizumi
中泉 政博
▼榊▲山 昭二
Shoji Sakakiyama
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NIPPON KOTAI KENKYUSHO KK
NIPPON KOUTAI KENKYUSHO KK
Sekisui Chemical Co Ltd
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NIPPON KOTAI KENKYUSHO KK
NIPPON KOUTAI KENKYUSHO KK
Sekisui Chemical Co Ltd
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Abstract

<P>PROBLEM TO BE SOLVED: To provide a carrier for blood component absorption which is simple to form, safe and strong enough to use for an extracorporeal circulation treatment, and its production method. <P>SOLUTION: The carrier for blood component absorption 3 has a multilayer structure consisting of an inner layer 1, and an outer layer 2 which is configured surrounding the inner layer 1 and is made of biocompatible materials. <P>COPYRIGHT: (C)2004,JPO

Description

 本発明は、血液の成分吸着に用いられる担体及びその製造方法に関し、特に、体外循環治療法に用いるのに適した血液成分吸着用担体及びその製造方法に関する。 The present invention relates to a carrier used for blood component adsorption and a method for producing the same, and more particularly to a blood component adsorption carrier suitable for use in extracorporeal circulation therapy and a method for producing the same.

 血液中から特定の成分のみを吸着・除去する方法として、従来より種々の方法が提案されている。例えば、下記の特許文献1には、顆粒球を効果的に吸着し得る担体として、酢酸セルロースなどからなる粒子状の担体が開示されている。この粒子状の担体では、担体表面に存在する官能基や表面形状により、この表面に特定の物質が吸着されるように構成されている。また、上記粒子状担体の他、繊維状の担体も用いられている。なお、上記粒子状担体は通常射出成形により製造されており、他方、繊維状担体の場合は押し出し成形により主として製造されていた。 Various methods have been proposed as methods for adsorbing and removing only specific components from blood. For example, Patent Document 1 below discloses a particulate carrier made of cellulose acetate or the like as a carrier capable of adsorbing granulocytes effectively. The particulate carrier is configured such that a specific substance is adsorbed on the surface by a functional group or surface shape present on the carrier surface. In addition to the above particulate carriers, fibrous carriers are also used. The particulate carrier is usually produced by injection molding, while the fibrous carrier is mainly produced by extrusion molding.

 しかしながら、上記の酢酸セルロースのような担体は、成形し難く、特に球状(粒子状)にし難いものであった。さらに従来の担体の中には大量使用時、担体が分解され、担体分解産物に起因すると思われる身体的症状の発生の可能性が考えられている。さらに、担体の中には強度的に体外循環用担体として耐え難い担体材料も存在し、このような担体材料はたとえ吸着能に優れていても、担体の割れや欠けにより発生した微粒子が体外循環回路内に流入する可能性が考えられていた。
特開平2−193069号公報
However, a carrier such as the above-mentioned cellulose acetate is difficult to mold, particularly to a spherical shape (particle shape). Further, it has been considered that some conventional carriers may be degraded when used in large amounts, and may cause physical symptoms that may be caused by the decomposition products of the carriers. Furthermore, there are carrier materials that are difficult to withstand as a carrier for extracorporeal circulation in the carrier, and even if such a carrier material has excellent adsorption capacity, fine particles generated by cracking or chipping of the carrier will cause extracorporeal circulation circuits. It was thought that there was a possibility of inflow.
JP-A-2-193969

 本発明の目的は、上述した従来の血液成分吸着用担体の改良体として、従来材料を用いつつ、担体成形を容易にし、より安全性が確保され、かつ体外循環治療に用いるのに十分な強度を有する血液成分吸着用担体及びその製造方法を提供することにある。 An object of the present invention is to provide an improved body of the above-mentioned conventional carrier for adsorbing blood components, using a conventional material, facilitating the molding of the carrier, ensuring more safety, and having sufficient strength to be used for extracorporeal circulation treatment. It is an object of the present invention to provide a blood component-adsorbing carrier having the above and a method for producing the same.

 本願発明者は、上述した従来の血液成分吸着用担体の改良点に付き鋭意検討した結果、複数の層からなる多層構造を有するように血液成分吸着用担体を構成すれば、上記課題を達成し得ることを見いだし、本発明をなすに至った。 The inventor of the present application has earnestly studied the improvement points of the conventional blood component adsorption carrier described above, and as a result, if the blood component adsorption carrier is constituted so as to have a multilayer structure composed of a plurality of layers, the above-described object can be achieved. It has been found that the present invention has been made.

 すなわち、本発明の血液成分吸着用担体は、生体適合性材料よりなる外層と、外層より内側に構成された内層とを少なくとも備える多層構造の血液成分吸着用担体である。 That is, the carrier for adsorbing blood components of the present invention is a carrier for adsorbing blood components having a multilayer structure including at least an outer layer made of a biocompatible material and an inner layer formed inside the outer layer.

 また、本発明の特定的な局面によれば、上記内層は、外層よりも機械的強度の高い材料で構成され、それによって外層として機械的強度が不十分である生体適合性材料を用いた場合であっても、血液成分吸着用担体全体としての機械的強度を効果的に高めることができる。 According to a specific aspect of the present invention, the inner layer is formed of a material having a higher mechanical strength than the outer layer, whereby a biocompatible material having insufficient mechanical strength is used as the outer layer. Even so, the mechanical strength of the entire blood component adsorption carrier can be effectively increased.

 また、本発明の血液成分吸着用担体の製造方法は、請求項1に記載の血液成分吸着用担体の製造方法であって、対向し合う第1,第2の面に、それぞれ、第1,第2の略半球状成形凹部を有し、第1の略半球状成形凹部よりも第2の略半球状成形凹部の径が大きくされている回転金型を用意する工程と、前記第1の成形凹部に、第1の成形凹部と組合わさって相対的に径の小さい第1の球状成形部を構成する第3の略半球状成形凹部を有する第2の金型を当接させて第1の球状成形部を構成するとともに、第2の成形凹部に、第2の成形凹部と組合わさって相対的に径の大きな第2の球状成形部を構成する第4の略半球状成形凹部を有する第3の金型を、第2の球状成形部内に該球状成形部の径よりも小さな径を有する治具を配置した状態で当接させて、前記治具が収納された第2の球状成形部を構成する工程と、前記第1の球状成形部に内層を構成する樹脂を、第2の球状成形部に外層を構成する樹脂を注入し、それによって、第1の球状成形部において球状成形体よりなる内層を、第2の球状成形部において、治具の周囲に略半球状の外表面を有する外層半体を形成する工程と、前記第2,第3の金型を前記回転金型から分離し、回転金型の第1,第2の成形凹部に、それぞれ前記球状の成形体及び外層半体を保持させる工程と、前記回転金型を回転させる工程と、前記回転金型の第1の成形凹部から球状成形体を取り出すとともに、第2の成形凹部から治具を取外し、外層半体のみを第2の成形凹部に保持させる工程と、前記第2の成形凹部内に前記球状成形体を押し込み、第2の成形凹部内の外層半体に該球状成形体を付着させる工程と、前記回転金型を回転させ、第2の略半球状成形凹部を第3の金型の第4の略半球状成形凹部とを組み合わせて第2の球状成形部を再度形成する工程と、前記第2の球状成形部に外層を構成する樹脂を再度注入し、球状成形体の周囲に外層を形成する工程とを備える、血液成分吸着用担体の製造方法である。 Further, the method for producing a blood component adsorption carrier of the present invention is the method for producing a blood component adsorption carrier according to claim 1, wherein the first and second surfaces facing each other have the first and second surfaces, respectively. A step of preparing a rotary mold having a second substantially hemispherically shaped recess, wherein the diameter of the second substantially hemispherically shaped recess is larger than that of the first substantially hemispherically shaped recess; A second mold having a third substantially hemispherical molding concave portion that forms a first spherical molding portion having a relatively small diameter in combination with the first molding concave portion is brought into contact with the molding concave portion, and a first mold is formed. And the second molding recess has a fourth substantially hemispherical molding recess which, in combination with the second molding recess, forms a second spherical molding having a relatively large diameter. A state in which a jig having a smaller diameter than the diameter of the spherical molded portion is arranged in the second mold in the third mold. A step of forming a second spherical molded part in which the jig is housed by abutting, and forming a resin constituting an inner layer in the first spherical molded part, and constituting an outer layer in a second spherical molded part. A resin is injected, thereby forming an inner layer made of a spherical molded body in the first spherical molded part and an outer layer half having a substantially hemispherical outer surface around a jig in the second spherical molded part. Separating the second and third molds from the rotating mold, and holding the spherical molded body and the outer layer half in the first and second molding recesses of the rotating mold, respectively. Rotating the rotary mold, removing the spherical molded body from the first molded concave portion of the rotary mold, removing the jig from the second molded concave portion, and removing only the outer layer half into the second molded concave portion. And pressing the spherical molded body into the second molded concave portion Adhering the spherical molded body to the outer layer half in the second molding concave part, and rotating the rotary mold so that the second substantially hemispherical molded concave part becomes the fourth substantially hemispherical part of the third mold. The step of forming the second spherical molded portion again by combining with the molding concave portion, and the step of injecting the resin constituting the outer layer into the second spherical molded portion again to form the outer layer around the spherical molded body. This is a method for producing a blood component adsorption carrier.

 また、本発明の血液成分吸着用担体の製造方法の特定的な局面では、上記第1の成形凹部から球状成形体を取り出す工程が、吸引チャックなどの吸引手段により、球状成形体を吸引・保持し、吸引手段を第1の成形凹部から後退させることにより行われる。 In a specific aspect of the method for producing a blood component-adsorbing carrier of the present invention, the step of taking out the spherical molded body from the first molded concave portion includes sucking and holding the spherical molded body by a suction means such as a suction chuck. This is performed by retracting the suction means from the first molding recess.

 また、本発明の別の特定的な局面では、上記第2の成形凹部から治具を取り外す工程は、第2の成形凹部を下方に向け、治具を第2の成形凹部から重力により落下させることにより行われる。 In another specific aspect of the present invention, in the step of removing the jig from the second molding recess, the second molding recess is directed downward, and the jig is dropped from the second molding recess by gravity. It is done by doing.

 本発明の製造方法のさらに他の局面では、上記球状成形体を第2の成形凹部内に押し込む工程は、吸引チャックなどの吸引手段に保持された球状成形体を、該吸引手段を第2の成形凹部に向かって移動させることにより行われる。 In still another aspect of the production method of the present invention, the step of pushing the spherical molded body into the second molding concave portion includes the step of: moving the spherical molded body held by a suction unit such as a suction chuck to the second molding unit. It is performed by moving toward the forming recess.

 本発明の血液成分吸着用担体では、外層が生体適合性材料よりなり、かつ従来から用いられていた血液成分吸着用担体と同様の材料で構成されている。すなわち、本発明においては、外層は血液成分の吸着能力を高めるための表面官能基を有するような材料、血液成分吸着能力に優れた材料、表面性状が血液成分の吸着に適したように構成されている材料等により構成されている。すなわち、外層は、血液成分吸着層として機能する。 で は In the carrier for adsorbing blood components of the present invention, the outer layer is made of a biocompatible material, and is made of the same material as the carrier for adsorbing blood components used conventionally. That is, in the present invention, the outer layer is configured so as to have a material having a surface functional group for increasing the blood component adsorption ability, a material having an excellent blood component adsorption ability, and a surface property suitable for the blood component adsorption. And the like. That is, the outer layer functions as a blood component adsorption layer.

 他方、本発明の血液成分吸着用担体の内層は、上記外層よりも内側に設けられている。内層は、本発明の血液成分吸着用担体の核として機能するものであり、血液成分吸着用担体の機械的強度を高めたり、担体分解産物の生成量の抑制を果たすように機能する。すなわち、内層が設けられている分だけ、外層を構成する材料の使用量を少なくすることができ、従って担体分解生成物量を抑制することができる。 On the other hand, the inner layer of the blood component adsorption carrier of the present invention is provided inside the outer layer. The inner layer functions as a core of the carrier for adsorbing blood components of the present invention, and functions to increase the mechanical strength of the carrier for adsorbing blood components and to suppress the amount of decomposition products of the carrier. In other words, the amount of the material constituting the outer layer can be reduced by the provision of the inner layer, so that the amount of the carrier decomposition product can be suppressed.

 例えば、これまで繊維状担体としては機械的強度が不足するため不適当とされていたゲル状のポリビニルアルコールを例にとると、本発明では、多層押し出し成形法を用いて内層をポリプロピレン等の強度に優れた樹脂材料により、外層をゲル状ポリビニルアルコールにより構成することにより、機械的強度に優れた血液成分吸着用担体を構成することができる。すなわち、本発明の構成を採用することにより、血液成分吸着用担体として用いることができなかったゲル状ポリビニルアルコールを用いて上記担体を構成することが可能となる。 For example, taking the case of gel-like polyvinyl alcohol, which was previously considered unsuitable due to insufficient mechanical strength as a fibrous carrier, in the present invention, the inner layer is made of polypropylene or the like using a multilayer extrusion molding method. By forming the outer layer from gel-like polyvinyl alcohol using a resin material having excellent mechanical properties, a carrier for adsorbing blood components having excellent mechanical strength can be provided. That is, by employing the configuration of the present invention, it is possible to configure the above carrier using gel-like polyvinyl alcohol which could not be used as a carrier for adsorbing blood components.

 また、従来、射出成形法により成形されていた酢酸セルロース担体は、その成形精度が不安定であり、かつ大量使用時に担体分解産物に起因すると思われる身体的症状の発生の可能性が考えられている。本発明では、外層を酢酸セルロースで構成し、内層をポリカーボネート樹脂等の他の樹脂材料により構成することにより、酢酸セルロースの使用量を減らすことができ、大量使用時の担体分解産物の生成量を抑制することが可能である。 Also, conventionally, cellulose acetate carriers molded by the injection molding method, the molding accuracy is unstable, and the possibility of physical symptoms considered to be caused by the carrier decomposition products when used in large quantities is considered. I have. In the present invention, the outer layer is formed of cellulose acetate, and the inner layer is formed of another resin material such as a polycarbonate resin, so that the amount of cellulose acetate used can be reduced, and the amount of carrier decomposition products generated when used in large quantities is reduced. It is possible to suppress.

 なお、外層に酢酸セルロースを用い、内層にポリカーボネート樹脂を用いて多層構造の担体を形成する方法としては、例えば特開昭59−220342号公報や特開昭62−156917号公報に記載の製造方法を適宜用いることができる。 In addition, as a method of forming a carrier having a multilayer structure using cellulose acetate for the outer layer and polycarbonate resin for the inner layer, for example, the production method described in JP-A-59-220342 and JP-A-62-156917 is known. Can be used as appropriate.

 上記のように、本発明の血液成分吸着用担体は、外層と内層とを有する多層構造で構成されているが、内層は、外層よりも内側に構成されてさえおればよく、従って外層と内層との間に1以上の中間層が形成されていてもよい。 As described above, the blood component adsorption carrier of the present invention has a multilayer structure having an outer layer and an inner layer, but the inner layer only needs to be formed on the inner side of the outer layer. And one or more intermediate layers may be formed between them.

 本発明において上記外層を構成する生体適合性材料としては、上記酢酸セルロース等のセルロース系材料の他、6−ナイロン、11−ナイロン等のナイロン;ポリスチレン、ポリトリフルオロエチレン、ポリエチレンテレフタレート、2−ヒドロキシエチルメタクリレート、ポリメタクリル酸メチル、ポリビニルアルコール等の様々な樹脂材料を挙げることができる。また、これらの樹脂材料の選択は、目的とする吸着対象である血液成分に応じて適宜選択される。 In the present invention, as the biocompatible material constituting the outer layer, in addition to the above-mentioned cellulose-based materials such as cellulose acetate, nylon such as 6-nylon and 11-nylon; polystyrene, polytrifluoroethylene, polyethylene terephthalate, 2-hydroxy Various resin materials such as ethyl methacrylate, polymethyl methacrylate, and polyvinyl alcohol can be used. The selection of these resin materials is appropriately selected according to the target blood component to be adsorbed.

 本発明の血液成分吸着用担体の内層を構成する材料としては、上記外層に用いられる材料の他、ポリプロピレン、ポリエチレン、ポリカーボネート等の合成樹脂、鉄、アルミ、もしくは銅などの金属、セラミックスまたはガラスなどの無機材料を用いることができる。すなわち、内層を構成する材料は特に制限されるものではない。もっとも、血液成分吸着用担体の機械的強度を高めるためには、内層を構成する材料として、外層を構成している材料よりも機械的強度の高い材料、すなわち、金属や機械的強度に優れた合成樹脂、例えば、ポリカーボネート等を用いることが望ましい。さらに、溶出物を発生しないほうが安全性の点で好ましいため、溶出物を発生し難い、ガラスなどにより内層を構成することも好ましい。 The material constituting the inner layer of the blood component adsorption carrier of the present invention includes, in addition to the materials used for the outer layer, synthetic resins such as polypropylene, polyethylene, and polycarbonate; metals such as iron, aluminum, and copper; and ceramics and glass. Inorganic material can be used. That is, the material constituting the inner layer is not particularly limited. However, in order to increase the mechanical strength of the blood component adsorption carrier, as a material constituting the inner layer, a material having a higher mechanical strength than the material constituting the outer layer, that is, a metal or a material having excellent mechanical strength It is desirable to use a synthetic resin such as polycarbonate. Furthermore, since it is preferable not to generate an eluted substance from the viewpoint of safety, it is also preferable to form the inner layer with glass or the like, which does not easily generate an eluted substance.

 いずれにしても、上述した外層及び内層を構成する材料は、血液成分吸着用担体の目的及び用途に応じ適宜選択される。 In any case, the material constituting the outer layer and the inner layer described above is appropriately selected according to the purpose and use of the blood component adsorption carrier.

 また、本発明の血液成分吸着用担体の形状については特に限定されるものではなく、例えば図1に示すように、球状内層1の外側に外層2を形成し、全体を球状の血液成分吸着用担体3としてもよく、あるいは図2に示すように、柱状の内層4の周囲に外層5を形成し、全体として棒状の血液成分吸着用担体6としてもよい。 The shape of the carrier for adsorbing blood components of the present invention is not particularly limited. For example, as shown in FIG. 1, an outer layer 2 is formed outside a spherical inner layer 1, and the whole is formed into a spherical blood component adsorbing carrier. The carrier 3 may be used. Alternatively, as shown in FIG. 2, an outer layer 5 may be formed around a columnar inner layer 4 to form a rod-shaped blood component adsorption carrier 6 as a whole.

 本発明では、血液成分吸着用担体が生体適合性材料よりなる外層と、内層とを有する多層構造で構成されている。従って、内層が構成されている分だけ、外層構成材料の使用料を低減することができるため、外層構成材料からの分解生成物の発生量を低減することができ、それによってより安全性を高め得る。 According to the present invention, the carrier for adsorbing blood components has a multilayer structure having an outer layer made of a biocompatible material and an inner layer. Therefore, the usage fee of the outer layer forming material can be reduced by the amount of the inner layer, so that the amount of decomposition products generated from the outer layer forming material can be reduced, thereby improving safety. obtain.

 また、内層構成材料の選択により、例えば内層構成材料として機械的強度に優れた材料を用いることにより、血液成分吸着用担体の機械的強度を効果的に高め得る。なお、上記のように、上述した外層及び内層を有する多層構造の担体の形成方法は、特開昭59−220342号公報や特開昭62−156917号公報に記載のような製造方法を適宜採用し得るが、本発明の他の局面によれば、上記請求項2に記載の製造方法が適用され、この製造方法を用いることにより、本発明の血液成分吸着用担体を容易にかつ連続的に得ることができる。 に よ り Also, by selecting the material constituting the inner layer, for example, by using a material having excellent mechanical strength as the material constituting the inner layer, the mechanical strength of the blood component adsorption carrier can be effectively increased. As described above, as a method for forming a carrier having a multilayer structure having an outer layer and an inner layer, a production method described in JP-A-59-220342 or JP-A-62-156917 is appropriately employed. However, according to another aspect of the present invention, the production method according to claim 2 is applied, and by using this production method, the blood component adsorption carrier of the present invention can be easily and continuously produced. Obtainable.

 以上のように、本発明の血液成分吸着用担体は、生体適合性材料よりなる外層と内層とを有する多層構造で構成されているため、内層を設けた分だけ生体適合性材料の使用量を減らすことができ、従って血液成分吸着用担体からの担体分解生成物や溶出物の量を低減することができる。 As described above, the blood component adsorption carrier of the present invention has a multilayer structure having an outer layer and an inner layer made of a biocompatible material, so that the amount of the biocompatible material used is reduced by the amount of the inner layer. Therefore, the amount of carrier decomposition products and elutes from the carrier for adsorbing blood components can be reduced.

 また、内層を構成する材料として、外層に比べて機械的に優れた材料を用いることにより、血液成分吸着用担体の機械的強度を効果的に高め得る。 In addition, by using a material that is mechanically superior to the outer layer as a material constituting the inner layer, the mechanical strength of the blood component adsorption carrier can be effectively increased.

 よって、本発明によれば、例えば体外循環治療に用いた場合、従来の血液成分吸着用担体に比べてより安全性を高めることができる。しかも、内層構成材料を選択することにより、従来使用することが出来ないとされていた材料を用いて外層を構成することができ、よって、血液成分吸着能が優れていながら従来使用不可能であった材料を用いて血液成分を吸着することも可能となる。 Therefore, according to the present invention, for example, when used for extracorporeal circulation treatment, the safety can be further improved as compared with a conventional blood component adsorption carrier. In addition, by selecting the material for forming the inner layer, the outer layer can be formed using a material which has been regarded as unusable in the past. It is also possible to adsorb blood components using such materials.

 また、本発明の血液成分吸着用担体の製造方法によれば、前述した回転金型並びに第1,第2の金型を上記治具と組み合わせて用いることにより、外層と内層とを有する本発明にかかる血液成分吸着用担体を容易にかつ確実に得ることが可能となる。 Further, according to the method for producing a blood component adsorption carrier of the present invention, the present invention having an outer layer and an inner layer by using the above-mentioned rotary mold and the first and second molds in combination with the above jig. , The carrier for adsorbing blood components can be easily and reliably obtained.

 本発明の血液成分吸着用担体の製造方法の一例を、図面を参照しつつ説明する。 An example of the method for producing the blood component adsorption carrier of the present invention will be described with reference to the drawings.

 図3〜図9は、それぞれ、本発明の吸着用担体の製造方法を説明するための各断面図である。 FIGS. 3 to 9 are cross-sectional views for explaining the method for producing the adsorption carrier of the present invention.

 本実施形態では、上記血液成分吸着用担体を射出成形方法を用いることにより製造する。まず、図3に示すように、本実施形態で用いる製造装置10は、第1の金型としての回転金型11と、第2,第3の金型12,13とを有する。回転金型11は、図3の点Oを紙面−紙背方向に通る中心軸の周りに回転可能に構成されている。また、回転金型11は、互いに対向し合う第1の面11aと第2の面11bとを有する。第1の面11aには、第1の略半球状成形凹部14が中央に形成されている。他方、第2の面11bには、第2の略半球状成形凹部15が形成されている。第2の略半球状成形凹部15の径は、第1の略半球状成形凹部14の径よりも大きくされている。 In the present embodiment, the carrier for adsorbing blood components is manufactured by using an injection molding method. First, as shown in FIG. 3, a manufacturing apparatus 10 used in the present embodiment includes a rotary mold 11 as a first mold, and second and third molds 12 and 13. The rotary mold 11 is configured to be rotatable around a central axis passing through a point O in FIG. 3 in a paper-back direction. The rotary mold 11 has a first surface 11a and a second surface 11b facing each other. On the first surface 11a, a first substantially hemispherical shaped concave portion 14 is formed at the center. On the other hand, a second substantially hemispherical shaped concave portion 15 is formed on the second surface 11b. The diameter of the second substantially hemispherical concave portion 15 is larger than the diameter of the first substantially hemispherical concave portion 14.

 また、第2の金型12の外表面12aの中央には、第3の略半球状成形凹部16が形成されている。第3の略半球状成形凹部16は、図3に示されているように、第1の略半球状成形凹部14と組み合わされて、第1の球状成形部17を形成している。また、第3の略半球状成形凹部16には樹脂を注入するための孔18が開口しており、孔18には、樹脂を射出するためのノズル19が連結されている。 A third substantially hemispherical concave portion 16 is formed at the center of the outer surface 12a of the second mold 12. As shown in FIG. 3, the third substantially hemispherical shaped concave portion 16 is combined with the first substantially hemispherical shaped concave portion 14 to form a first spherical molded portion 17. Further, a hole 18 for injecting a resin is opened in the third substantially hemispherical molded concave portion 16, and a nozzle 19 for injecting the resin is connected to the hole 18.

 また、第2の金型12は、図示しない往復駆動源により、図示の矢印A方向に移動可能に構成されている。 The second mold 12 is configured to be movable in a direction indicated by an arrow A by a reciprocating drive source (not shown).

 第3の金型13においては、外表面13aの中央に第4の略半球状成形凹部20が形成されている。第4の略半球状成形凹部20は、第2の略半球状成形凹部15と組み合わされて、第2の球状成形部21を形成している。従って、第4の略半球状成形凹部20の径は、第2の半球状成形凹部15の径と同一とされており、かつ組み合われた状態で、第4の略半球状成形凹部20の中心が第2の略半球状成形凹部15の中心と一致されるように構成されている。 In the third mold 13, a fourth substantially hemispherical molded concave portion 20 is formed at the center of the outer surface 13a. The fourth substantially hemispherically shaped recess 20 is combined with the second substantially hemispherically shaped recess 15 to form a second spherically shaped portion 21. Therefore, the diameter of the fourth substantially hemispherically shaped concave portion 20 is the same as the diameter of the second substantially hemispherically shaped concave portion 15, and the center of the fourth substantially hemispherically shaped concave portion 20 in the combined state. Is formed so as to coincide with the center of the second substantially hemispherical shaped concave portion 15.

 さらに、図3に示す初期状態では、第2の球状成形部21内に、治具22が配置されている。治具22は、本実施形態では、第4の略半球状成形凹部25を埋め尽くしている部分22aと、第2の略半球状成形凹部15内において配置されている相対的に径の小さな略半球状部分22bとを有する。略半球状部分22bの径は、第1の球状成形部17の径と同等とされている。従って、治具22の半球状部分22bの外表面と、第2の略半球状成形凹部15の内面との間には、外層の半分の形状に応じた空間Bが構成されている。 Furthermore, in the initial state shown in FIG. 3, the jig 22 is arranged in the second spherical molded part 21. In the present embodiment, the jig 22 includes a portion 22a that fills the fourth substantially hemispherical shaped concave portion 25 and a substantially small-diameter generally arranged inside the second substantially hemispherical shaped concave portion 15. And a hemispherical portion 22b. The diameter of the substantially hemispherical portion 22b is equal to the diameter of the first spherical molded portion 17. Therefore, a space B corresponding to half the shape of the outer layer is formed between the outer surface of the hemispherical portion 22b of the jig 22 and the inner surface of the second substantially hemispherical concave portion 15.

 第3の金型13についても、図示しない往復駆動源に連結されており、それによって図示の矢印A方向に往復移動され得るように構成されている。 The third mold 13 is also connected to a reciprocating drive source (not shown) so that it can be reciprocated in the direction of arrow A shown in the figure.

 なお、第3の金型13においても、樹脂を注入するための孔23が形成されており、孔23には、樹脂を射出するためのノズル24が連結されている。 も In the third mold 13 as well, a hole 23 for injecting the resin is formed, and a nozzle 24 for injecting the resin is connected to the hole 23.

 本実施形態では、図3に示す初期状態おいて、ノズル19から、内層を構成するための樹脂を射出し、第1の球状成形部17に充填するとともに、ノズル24から外層を構成するための樹脂を第2の球状成形部21内に充填する。上記樹脂を充填した後、充填された樹脂を硬化させ、しかる後、図4に示すように、第2,第3の金型12,13を回転金型11から分離する。 In the present embodiment, in the initial state shown in FIG. 3, a resin for forming the inner layer is injected from the nozzle 19 to fill the first spherical molded portion 17 and to form the outer layer from the nozzle 24. The resin is filled in the second spherical molded portion 21. After filling the resin, the filled resin is cured, and thereafter, the second and third molds 12 and 13 are separated from the rotary mold 11 as shown in FIG.

 図4から明らかなように、第2の金型12と第3の金型13とを、それぞれ回転金型11から遠ざかるように移動させることにより、第1の球状成形部17で成形された球状成形体25が露出する。球状成形体25は、本発明の血液成分吸着用担体の内層を構成する部分に相当する。他方、第2の略半球状成形凹部15では、前述した空間Bに注入された樹脂が固化されることより、外表面が半球状の形状を有する外層半体26が形成されている。この場合、治具22は、外層半体26に付着されたまま、回転金型11側に支持されている。 As is clear from FIG. 4, by moving the second mold 12 and the third mold 13 away from the rotary mold 11, respectively, the spherical mold formed by the first spherical molding portion 17 is formed. The molded body 25 is exposed. The spherical molded body 25 corresponds to a portion constituting an inner layer of the blood component adsorption carrier of the present invention. On the other hand, in the second substantially hemispherical molded concave portion 15, an outer layer half 26 having an outer surface having a hemispherical shape is formed by solidifying the resin injected into the space B described above. In this case, the jig 22 is supported by the rotary mold 11 while being attached to the outer layer half 26.

 次に、回転金型11を、図4に示した状態から、点Oを通る中心軸を中心に90度回転させる。その結果、図6に示すように、第2の略半球状成形凹部15が下を向くことになるため、重力により治具22が落下する。もっとも、外層半体26は、樹脂が完全には固化していないので樹脂の粘着力により、上記第2の略球状成形凹部15に保持されたままとなる。 Next, the rotary mold 11 is rotated 90 degrees about the central axis passing through the point O from the state shown in FIG. As a result, as shown in FIG. 6, since the second substantially hemispherical shaped concave portion 15 faces downward, the jig 22 drops due to gravity. However, since the resin is not completely solidified, the outer layer half 26 remains held in the second substantially spherical molded concave portion 15 by the adhesive force of the resin.

 なお、図5に要部を拡大して示すように、球状成形体25の中心Xは、回転金型11の面11aよりも内側に位置する。すなわち、本実施形態においては、第1の略半球状成形凹部14は、球を等分した形状よりも、若干大きく形成されている。従って、球状成形体の半分以上が、第1の略半球状成形凹部14内に埋め込まれた形態となっているため、回転金型11を回転させたとしても、第1の略半球状成形凹部14から落下し難い。 As shown in FIG. 5, the center X of the spherical molded body 25 is located inside the surface 11 a of the rotary mold 11. That is, in the present embodiment, the first substantially hemispherically shaped concave portion 14 is formed to be slightly larger than a shape obtained by equally dividing a sphere. Therefore, since more than half of the spherical molded body is embedded in the first substantially hemispherically shaped concave portion 14, even if the rotating mold 11 is rotated, the first substantially hemispherically shaped concave portion 14 is formed. It is hard to fall from 14.

 また、第1の略半球状成形凹部14において成形された球状成形体25は、図6に略図的に示されている吸引装置27により吸引される。次に、図7に示すように、吸引装置27により球状成形体25を吸引・保持し、上方に引き上げる。 球状 Further, the spherical molded body 25 molded in the first substantially hemispherical molded concave portion 14 is sucked by the suction device 27 schematically shown in FIG. Next, as shown in FIG. 7, the spherical molded body 25 is sucked and held by the suction device 27, and is pulled up.

 次に、球状成形体25を吸引装置27に保持した状態で、上方に引き上げた後に、回転金型11を上述した点Oを通る中心軸の周りに180度回転させる。その結果、図8に示すように、第2の略半球状成形凹部15が上方を向くように位置されることになる。そして、この第2の略半球状成形凹部15内に支持されている外層半体26に対し、上方から吸引装置27を降下させることにより、球状成形体25を押し込み、球状成形体25を外層半体26に密着させる。 Next, after the spherical molded body 25 is held by the suction device 27 and pulled up, the rotary mold 11 is rotated 180 degrees around the central axis passing through the point O described above. As a result, as shown in FIG. 8, the second substantially hemispherically shaped concave portion 15 is located so as to face upward. Then, by lowering the suction device 27 from above to the outer layer half 26 supported in the second substantially hemispherical molded concave portion 15, the spherical molded body 25 is pushed in, and the spherical molded body 25 is pushed into the outer layer half. Close contact with body 26.

 次に、回転金型11を、再度点Oを通る中心軸の周りに時計方向に90度回転させ、かつ第2,第3の金型12,13を初期状態のように回転金型11に当接させる。この状態を図9に示す。 Next, the rotating mold 11 is rotated clockwise again by 90 degrees around the central axis passing through the point O, and the second and third molds 12 and 13 are rotated to the rotating mold 11 as in the initial state. Abut. This state is shown in FIG.

 図9から明らかなように、回転金型11に、再度第2,第3の金型12,13が密着されて、第1,第2の球状成形部17,21が再度構成されている。この状態で、ノズル24から外層を構成する樹脂を第2の球状成形部21内に注入することにより、空間Cに外層を構成する樹脂が注入される。図9から明らかなように、第2の球状成形部21においては、残りの外層半体に相当する形状の空間Cが形成されている。すなわち、球状成形体25の径が、第4の略半球状成形凹部20の径よりも小さいため、上記空間Cが形成される。従って、この空間Cに樹脂が注入され、固化されることにより、残りの半分の外層半体が成形されることになる。注入された樹脂が硬化した後、第3の金型13を回転金型11から遠ざかるように移動させることにより、回転金型11と第3の金型13とを開き、第2の球状成形部21から得られた成形体を取り出す。 As is clear from FIG. 9, the second and third molds 12 and 13 are brought into close contact with the rotary mold 11 again, and the first and second spherical molded portions 17 and 21 are formed again. In this state, the resin forming the outer layer is injected into the space C by injecting the resin forming the outer layer into the second spherical molded portion 21 from the nozzle 24. As is clear from FIG. 9, a space C having a shape corresponding to the remaining outer layer half is formed in the second spherical molded portion 21. That is, since the diameter of the spherical molded body 25 is smaller than the diameter of the fourth substantially hemispherical molded concave portion 20, the space C is formed. Therefore, by injecting and solidifying the resin into the space C, the other half of the outer layer half is formed. After the injected resin is cured, the third mold 13 is moved away from the rotary mold 11 so that the rotary mold 11 and the third mold 13 are opened, and the second spherical molding portion is opened. The molded body obtained from 21 is taken out.

 上記のようにして、球状成形体25からなる内層の外表面に、外層半体26と、空間Cに注入された樹脂が固化されることにより形成された残りの外層半体とにより構成された外層が形成されている、本発明の血液成分吸着用担体を得ることができる。すなわち、本発明実施形態の製造方法では、上述した回転金型11、及び第2,第3の金型12,13を用いることにより、内層と外層とを有する本発明の血液成分吸着用担体を連続的に、かつ容易に製造することができる。 As described above, the outer layer half 26 and the remaining outer layer half formed by solidifying the resin injected into the space C were formed on the outer surface of the inner layer made of the spherical molded body 25. The carrier for adsorbing blood components of the present invention having an outer layer formed thereon can be obtained. That is, in the manufacturing method of the embodiment of the present invention, the carrier for blood component adsorption of the present invention having an inner layer and an outer layer is formed by using the above-described rotary mold 11 and the second and third molds 12 and 13. It can be manufactured continuously and easily.

 本実施形態では、上記球状成形体25を回転金型11から一旦分離し、回転された回転金型11の第2の略半球状成形凹部15に支持された外層半体26に押し込むに際し、吸引装置27を用いたが、吸引装置27以外に、機械的なチャック等により球状成形体25を上記のように分離し、かつ外層半体26上に押し込んでもよい。もっとも、真空吸引手段を用いた吸引装置27を用いた場合には、球状成形体25の表面に損傷を与え難いという利点がある。 In the present embodiment, when the spherical molded body 25 is once separated from the rotary mold 11 and pushed into the outer layer half 26 supported by the second substantially hemispherical molded concave portion 15 of the rotated rotary mold 11, suction is performed. Although the apparatus 27 is used, in addition to the suction apparatus 27, the spherical molded body 25 may be separated by a mechanical chuck or the like as described above, and may be pressed onto the outer layer half 26. However, when the suction device 27 using the vacuum suction means is used, there is an advantage that the surface of the spherical molded body 25 is hardly damaged.

 以下、本発明の非限定的な実施例を説明することにより、本発明を明らかにする。 Hereinafter, the present invention will be clarified by describing non-limiting examples of the present invention.

 実施例1
 内層として、直径1.0mmのポリカーボネート樹脂よりなる球状粒子を用意し、該ポリカーボネート粒子の外側に、酢酸セルロース層を外層として形成し、全体の直径が2.5mmの球状の粒子からなる血液成分吸着用担体を作製した。
Example 1
As the inner layer, spherical particles made of a polycarbonate resin having a diameter of 1.0 mm are prepared, and a cellulose acetate layer is formed as an outer layer on the outside of the polycarbonate particles, so that blood component adsorption consisting of spherical particles having an overall diameter of 2.5 mm is obtained. A carrier was prepared.

 実施例2
 長さ50cm及び径0.5mmのポリプロピレン繊維により内層を構成し、該ポリプロピレン繊維の外側にポリビニルアルコール架橋ゲルからなる外層を形成し、全体の長さが50cm及び径が1.0mmの繊維状の血液成分吸着用担体を作製し、実施例2とした。
Example 2
The inner layer is composed of polypropylene fibers having a length of 50 cm and a diameter of 0.5 mm, and an outer layer made of a polyvinyl alcohol crosslinked gel is formed outside the polypropylene fibers. A carrier for adsorbing blood components was prepared, and this was designated as Example 2.

 比較例1
 内層を構成せずに全体が2.3mmの径の球状の酢酸セルロースよりなる血液成分吸着用担体を比較例1とした。
Comparative Example 1
A blood component adsorption carrier made of spherical cellulose acetate having a diameter of 2.3 mm without forming an inner layer was used as Comparative Example 1.

 比較例2
 内層を構成せずに、ポリビニルアルコール架橋ゲルにより長さ50cm及び径1.0mmの繊維状の血液成分吸着用担体を作製し、比較例2とした。
Comparative Example 2
Without forming the inner layer, a fibrous blood component adsorption carrier having a length of 50 cm and a diameter of 1.0 mm was produced from a polyvinyl alcohol crosslinked gel, and Comparative Example 2 was obtained.

 実施例及び比較例の評価
 上述した実施例1,2及び比較例1,2の血液成分吸着用担体を体外循環用カラムに充填し、該カラムに体外循環回路構成用の樹脂チューブ及びポンプを接続し、回路を構成した。上記体外循環回路に、70℃の温度の生理食塩水を100cc/分の流速で1時間流し、しかる後生理食塩水のpHを測定した。結果を下記の表1に示す。
Evaluation of Examples and Comparative Examples The blood component adsorption carriers of Examples 1 and 2 and Comparative Examples 1 and 2 were packed in a column for extracorporeal circulation, and a resin tube and a pump for extracorporeal circulation circuit construction were connected to the column. Then, a circuit was configured. Physiological saline at a temperature of 70 ° C. was flowed through the extracorporeal circuit at a flow rate of 100 cc / min for 1 hour, and then the pH of the physiological saline was measured. The results are shown in Table 1 below.

 表1から明らかなように、比較例1,2では、pH値が、4.1及び3.5と低かった。これに対して、実施例1,2では、比較例1,2に比べてpH値が高く、より中性側に近いことから、中性域にある血液に与える影響がより少ないことがわかり、血液安定性がより高められることがわかる。 As is clear from Table 1, in Comparative Examples 1 and 2, the pH value was as low as 4.1 and 3.5. On the other hand, in Examples 1 and 2, since the pH value was higher than that of Comparative Examples 1 and 2 and closer to the neutral side, it was found that the influence on blood in the neutral region was smaller, It can be seen that blood stability is further improved.

 従って、上記実施及び比較例の評価から明らかなように、70℃の生理食塩水を用いて体外循環した場合でも、実施例1,2では、吸着用担体の血液安定性が高められ、かつ機械的強度も高められているため、担体分解生成物の発生や担体の破損等が生じ難く、従ってより安全な血液成分吸着用担体を提供し得ることがわかる。 Therefore, as is clear from the evaluations of the above Examples and Comparative Examples, even in the case of extracorporeal circulation using physiological saline at 70 ° C., in Examples 1 and 2, the blood stability of the carrier for adsorption was enhanced, and Since the mechanical strength is also increased, generation of carrier decomposition products, breakage of the carrier, and the like are less likely to occur, and thus it can be seen that a more secure carrier for adsorbing blood components can be provided.

本発明の血液成分吸着用担体の一構造例を示す部分切欠断面斜視図。FIG. 2 is a partially cutaway perspective view showing one structural example of the blood component adsorption carrier of the present invention. 本発明の血液成分吸着用担体の他の構造例を示す斜視図。FIG. 4 is a perspective view showing another example of the structure of the blood component adsorption carrier of the present invention. 本発明の血液成分吸着用担体の製造方法についての一実施形態において用いられる製造装置の要部の初期状態を示す部分切欠断面図。1 is a partially cutaway sectional view showing an initial state of a main part of a manufacturing apparatus used in an embodiment of a method for manufacturing a blood component adsorption carrier of the present invention. 本発明の一実施形態で用いられる製造装置及び、球状成形体及び外層半体を成形した状態を示す部分切欠断面図。The manufacturing apparatus used by one Embodiment of this invention, and a partially notched sectional view which shows the state which shape | molded the spherical molded object and the outer layer half. 球状成形体が第1の略半球状成形凹部に支持されている状態を示す要部拡大断面図。The principal part expanded sectional view which shows the state in which the spherical molded object was supported by the 1st substantially hemispherical-shaped recessed part. 本発明の一実施形態にかかる製造方法に用いられる製造装置において、回転金型から治具を除去する工程を説明するための部分切欠断面図。FIG. 3 is a partially cutaway sectional view for explaining a step of removing a jig from a rotary mold in a manufacturing apparatus used in the manufacturing method according to one embodiment of the present invention. 本発明の一実施形態の製造方法において、球状成形体を回転金型から分離する工程を説明するための部分切欠断面図。FIG. 4 is a partially cutaway sectional view for explaining a step of separating the spherical molded body from the rotary mold in the manufacturing method according to the embodiment of the present invention. 本発明の一実施形態の製造方法において、第2の略半球状成形凹部に支持された外層半体に、球状成形体を押し込む工程を説明するための部分切欠断面図。FIG. 9 is a partially cutaway sectional view for explaining a step of pushing a spherical molded body into an outer layer half supported by a second substantially hemispherical molded concave portion in the manufacturing method according to the embodiment of the present invention. 本発明の一実施形態の製造方法において、残りの外層半体を成形する工程を説明するための部分切欠断面図。FIG. 5 is a partially cutaway sectional view for explaining a step of forming the remaining outer layer half in the manufacturing method according to the embodiment of the present invention.

符号の説明Explanation of reference numerals

 10…製造装置
 11…金型
 11a…第1の面
 11b…第2の面
 12,13…金型
 12a…外表面
 13a…外表面
 14…第1の略半球状成形凹部
 15…第2の略半球状成形凹部
 16…第3の略半球状成形凹部
 17…第1の球状成形部
 18…孔
 19…ノズル
 20…第4の略半球状成形凹部
 21…第2の球状成形部
 22…治具
 22b…略半球状部分
 23…孔
 24…ノズル
 25…球状成形体
 26…外層半体
 27…吸引装置
DESCRIPTION OF SYMBOLS 10 ... Manufacturing apparatus 11 ... Die 11a ... 1st surface 11b ... 2nd surface 12, 13 ... Die 12a ... Outer surface 13a ... Outer surface 14 ... 1st substantially hemispherical-shaped recessed part 15 ... 2nd substantially Hemispherical molded concave portion 16: Third substantially semispherical molded concave portion 17: First spherical molded portion 18: Hole 19: Nozzle 20: Fourth substantially semispherical molded concave portion 21: Second spherical molded portion 22: Jig 22b: a substantially hemispherical part 23 ... a hole 24 ... a nozzle 25 ... a spherical molded body 26 ... an outer half half 27 ... a suction device

Claims (12)

 血液成分の吸着に用いられる担体であって、
 生体適合性材料からなる外層と、前記外層よりも内側に形成された内層とを少なくとも備えることを特徴とする血液成分吸着用担体。
A carrier used for adsorption of blood components,
A carrier for adsorbing blood components, comprising at least an outer layer made of a biocompatible material and an inner layer formed inside the outer layer.
 前記内層が、外層を構成している材料よりも機械的強度の高い材料で構成されている請求項1に記載の血液成分吸着用担体。 2. The carrier for adsorbing blood components according to claim 1, wherein the inner layer is made of a material having higher mechanical strength than the material forming the outer layer.  前記外層が、酢酸セルロースにより構成されている請求項1に記載の血液成分吸着用担体。 The carrier for adsorbing blood components according to claim 1, wherein the outer layer is made of cellulose acetate.  前記内層がポリカーボネートより構成されている請求項3に記載の血液成分吸着用担体。 4. The carrier for adsorbing blood components according to claim 3, wherein the inner layer is made of polycarbonate.  前記外層がポリビニルアルコール架橋ゲルにより構成されている、請求項1に記載の血液成分吸着用担体。 The carrier for adsorbing blood components according to claim 1, wherein the outer layer is formed of a polyvinyl alcohol crosslinked gel.  前記内層がポリプロピレンより構成されている請求項5に記載の血液成分吸着用担体。 The carrier for adsorbing blood components according to claim 5, wherein the inner layer is made of polypropylene.  前記血液成分吸着用担体が球状である、請求項1に記載の血液成分吸着用担体。 担 体 The blood component adsorption carrier according to claim 1, wherein the blood component adsorption carrier is spherical.  前記血成分吸着用担体が柱状の形状を有する請求項1に記載の血液成分吸着用担体。 The carrier for adsorbing blood components according to claim 1, wherein the carrier for adsorbing blood components has a columnar shape.  請求項1に記載の血液成分吸着用担体の製造方法であって、
 対向し合う第1,第2の面に、それぞれ、第1,第2の略半球状成形凹部を有し、第1の略半球状成形凹部よりも第2の略半球状成形凹部の径が大きくされている回転金型を用意する工程と、
 前記第1の成形凹部に、第1の成形凹部と組合わさって相対的に径の小さい第1の球状成形部を構成する第3の略半球状成形凹部を有する第2の金型を当接させて第1の球状成形部を構成するとともに、第2の成形凹部に、第2の成形凹部と組合わさって相対的に径の大きな第2の球状成形部を構成する第4の略半球状成形凹部を有する第3の金型を、第2の球状成形部内に該球状成形部の径よりも小さな径を有する治具を配置した状態で当接させて、前記治具が収納された第2の球状成形部を構成する工程と、
 前記第1の球状成形部に内層を構成する樹脂を、第2の球状成形部に外層を構成する樹脂を注入し、それによって、第1の球状成形部において球状成形体よりなる内層を、第2の球状成形部において、治具の周囲に略半球状の外表面を有する外層半体を形成する工程と、
 前記第2,第3の金型を前記回転金型から分離し、回転金型の第1,第2の成形凹部に、それぞれ前記球状の成形体及び外層半体を保持させる工程と、
 前記回転金型を回転させる工程と、
 前記回転金型の第1の成形凹部から球状成形体を取り出すとともに、第2の成形凹部から治具を取外し、外層半体のみを第2の成形凹部に保持させる工程と、
 前記第2の成形凹部内に前記球状成形体を押し込み、第2の成形凹部内の外層半体に該球状成形体を付着させる工程と、
 前記回転金型を回転させ、第2の略半球状成形凹部を第3の金型の第4の略半球状成形凹部とを組み合わせて第2の球状成形部を再度形成する工程と、
 前記第2の球状成形部に外層を構成する樹脂を再度注入し、球状成形体の周囲に外層を形成する工程とを備える、血液成分吸着用担体の製造方法。
A method for producing a blood component adsorption carrier according to claim 1,
The first and second surfaces facing each other have first and second substantially hemispherical shaped concave portions, respectively, and the diameter of the second substantially hemispherical shaped concave portion is larger than that of the first substantially hemispherical shaped concave portion. A step of preparing a rotating mold that has been enlarged,
A second mold having a third substantially hemispherical molded concave portion that forms a first spherical molded portion having a relatively small diameter in combination with the first molded concave portion is brought into contact with the first molded concave portion. To form a first spherical molded part, and in the second molded concave part, a fourth substantially hemispherical part which forms a second spherical molded part having a relatively large diameter in combination with the second molded concave part. A third mold having a molding recess is brought into contact with a jig having a diameter smaller than the diameter of the spherical molding portion in the second spherical molding portion, and the third mold in which the jig is stored is placed. A step of forming a spherical molded part of No. 2;
The resin constituting the inner layer is injected into the first spherical molded part, and the resin constituting the outer layer is injected into the second spherical molded part, whereby the inner layer composed of the spherical molded body in the first spherical molded part is formed into the second spherical molded part. A step of forming an outer layer half having a substantially hemispherical outer surface around the jig in the spherical molded portion of 2;
A step of separating the second and third molds from the rotary mold, and holding the spherical molded body and the outer layer half in the first and second molding recesses of the rotary mold, respectively;
Rotating the rotating mold;
Removing the spherical molding from the first molding recess of the rotary mold, removing the jig from the second molding recess, and holding only the outer layer half in the second molding recess;
Pushing the spherical molded body into the second molded concave portion, and attaching the spherical molded body to the outer layer half in the second molded concave portion;
Rotating the rotary mold, forming a second spherical molded portion again by combining the second substantially semispherical molded concave portion with the fourth substantially semispherical molded concave portion of the third mold,
Re-injecting the resin constituting the outer layer into the second spherical molded part, and forming an outer layer around the spherical molded body.
 第1の成形凹部から球状成形体を取り出す上記工程が、吸引手段により、球状成形体を吸引・保持し、吸引手段を第1の成形凹部から後退させることにより行われる、請求項9に記載の血液成分吸着用担体の製造方法。 The method according to claim 9, wherein the step of removing the spherical molded body from the first molding recess is performed by sucking and holding the spherical molded body by the suction means, and retracting the suction means from the first molding recess. A method for producing a carrier for adsorbing blood components.  前記第2の成形凹部から治具を取り外す工程が、第2の成形凹部を下方に向けて、治具を重力により落下させることにより行われる、請求項10に記載の血液成分吸着用担体の製造方法。 The manufacturing of the blood component adsorption carrier according to claim 10, wherein the step of removing the jig from the second molding recess is performed by dropping the jig by gravity with the second molding recess facing downward. Method.  前記球状成形体を前記第2の成形凹部内に押し込む工程が、前記吸引手段に保持された球状成形体を、該吸引手段を第2の成形凹部に向かって移動させることにより行われる、請求項10に記載の血液成分吸着用担体の製造方法。
The step of pushing the spherical molded body into the second molding concave part is performed by moving the spherical molded body held by the suction means toward the second molding concave part. 11. The method for producing a blood component adsorption carrier according to item 10.
JP2003358991A 1994-10-18 2003-10-20 Method for producing carrier for adsorbing blood components Expired - Lifetime JP3952406B2 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2013022012A1 (en) * 2011-08-09 2015-03-05 東レ株式会社 Adsorption carrier and method for producing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2013022012A1 (en) * 2011-08-09 2015-03-05 東レ株式会社 Adsorption carrier and method for producing the same

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