JP2004041231A - Method for vaporizing medicament - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method for vaporizing a medicament, vaporizing the medicament at room temperature under a condition of acting centrifugal force on a medicament-impregnated body in a cartridge. <P>SOLUTION: The method for vaporizing a medicament comprises storing a medicament-impregnated body 1 in a cartridge 2 having air holes on its side face and vaporizing the medicament impregnated in the medicament-impregnated body 1 under a condition of acting centrifugal force to the medicament-impregnated body by rotating the cartridge 2. The granular or almost granular medicament-impregnated body 1 has 1-10 mm average outer diameter and the medicament-impregnated body contains ≥100 mg medicament as a whole. And, as the medicament, a medicament volatilizing 0.01-0.5 mg/h medicament from the medicament-impregnated body 1 for 180 h or more is used. Thereby, many advantages such as keeping almost constant insecticidal potential for a long term, high safety and good usability are obtained. <P>COPYRIGHT: (C)2004,JPO

Description

The present invention relates to a chemical volatilization method in which a chemical force is volatilized at room temperature by applying centrifugal force to a granular or substantially granular chemical impregnated body housed in a replaceable cartridge and utilizing wind force generated at this time. More specifically, in the present invention, for example, the cartridge is attached to an air outflow side and / or an air inflow side of a sirocco fan, and a centrifugal force is applied to the drug impregnated body by rotating the cartridge with a motor. The present invention relates to a chemical volatilization method capable of volatilizing a chemical continuously from an impregnated body at a constant volatilization rate for a long time.

In order to exterminate pests such as mosquitoes and moths, mosquitoes using thermal energy are used as a chemical volatilization method that volatilizes and releases chemicals in the entire enclosed space (for example, indoors of buildings, cars, and outdoor sports tents). Incense sticks, electric mosquito mats, and liquid electric mosquito traps (liquids) are common, but methods of volatilizing and releasing chemicals using wind power such as fans at room temperature have also been attempted.

The chemical volatilization method using electricity from a fire or a power outlet may be difficult to use in terms of safety and securing a power source. For example, when used in a tent, it is preferable to use a method of volatilizing and releasing the drug at room temperature. In this case, if wind power such as a fan is used for volatilization of the drug, the drug (or drug impregnation) is used as it is. Compared with the case of leaving the body), the volatilization efficiency of the drug can be greatly increased.

Many methods have been proposed as methods for volatilizing and releasing a drug at room temperature. For example, Japanese Utility Model Application Laid-Open No. 61-182273 discloses an instrument configured to install an impregnated body that retains a drug and has an appropriate air permeability around a fan, and to apply air from the fan to the impregnated body. Yes. Japanese Patent Application Laid-Open No. 10-191862 discloses a method in which a granular drug impregnated body is placed in an impregnated container, and air is blown from the fan, and the drug impregnated body is stirred by wind force to volatilize the drug. It is disclosed. Further, JP-A-5-68459 discloses a method for diffusing a volatile drug that diffuses the volatile drug in the air by rotating a diffusion material holding the volatile drug.
Japanese Utility Model Publication No. 61-182273 JP-A-10-191862 JP-A-5-68459

However, in the instrument disclosed in Japanese Utility Model Laid-Open No. 61-182273 and the instrument used in the method disclosed in Japanese Patent Laid-Open No. 10-191862, the drug-impregnated body is stored in a stationary storage container. In the method disclosed in Japanese Patent Application Laid-Open No. 10-191862, attempts have been made to apply the wind from the fan to the granular material which is a drug-impregnated body and stir the granular material by wind force. It is difficult to sufficiently stir the entire granular material. Therefore, in the method of JP-A-10-191862, it is difficult to volatilize the drug from the granular material which is the drug impregnated material over a long period of time with a constant volatilization amount, and it is inevitable that the volatilization drug amount decreases with time. .

On the other hand, in the method disclosed in JP-A-5-68459, a diffusion material comprising a bag or container having a membrane part made of a gas permeable film or a bag or container having a ventable micropore filled with a volatile drug. Therefore, it is difficult to efficiently volatilize the drug from the entire volatile drug, and it is inevitable that the amount of the volatile drug decreases with time. Therefore, it is difficult to maintain a stable volatilization amount for a long period of 10 days or longer by this method.

The present invention is for solving the problems of the prior art, and the object of the present invention is that it can be applied in the field and can stably volatilize a substantially constant amount of drug over a long period of time. Another object of the present invention is to provide a chemical volatilization method that has many advantages such as high insecticidal efficacy, high safety, and good usability.

As a result of intensive studies to solve the problems of the prior art, the present inventors have applied a centrifugal force to a granular or substantially granular drug impregnated body for a long period of time (for example, 1 It has been found that stable volatilization performance can be achieved over a period of 30 days by using 12 hours a day, and the present invention has been completed.

That is, in the chemical volatilization method of the present invention, the granular or substantially granular chemical impregnated body is housed in a cartridge having a vent on the side surface, and the centrifugal force acts on the chemical impregnated body by rotation of the cartridge. A drug volatilization method for volatilizing a drug impregnated in a drug-impregnated body, wherein an average outer diameter of the granular or substantially granular drug-impregnated body is 3 mm to 10 mm, and the drug-impregnated body is impregnated with 100 mg or more of the drug as a whole. And the chemical | medical agent which can volatilize the chemical | medical agent from the said chemical | medical agent impregnated body at the volatilization amount of 0.01-0.5 mg per hour and 180 hours or more is used as the said chemical | medical agent, The said chemical | medical agent is the following groups: 4 -Methoxymethyl-2,3,5,6-tetrafluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate (compound K), 4- Lopargyl-2,3,5,6-tetrafluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate (Compound L) and 2,3,5,6-tetrafluorobenzyl-2,2,3 , 3-tetramethylcyclopropanecarboxylate (compound M), which is at least one kind of compound [hereinafter referred to as i)].

The following inventive method is particularly preferred.
ii) The chemical volatilization method according to i), wherein the centrifugal force has a magnitude of 9.8 × 10 ⁻¹ cm / s ^{2 to} 9.8 × 10 ⁴ cm / s ² .
iii) The chemical volatilization method according to i), wherein the chemical-impregnated body is filled in the cartridge with a porosity of 20% to 70%.
iv) The chemical volatilization method according to i), wherein the cartridge is rotated by a motor.
v) The chemical volatilization method according to iv), wherein the rotation speed of the motor is 100 to 2000 rpm.
vi) The chemical volatilization method according to i), wherein the cartridge is mounted on an air outflow side and / or an air inflow side of a sirocco fan.
vii) The chemical volatilization method according to vi), wherein the cartridge has an annular shape and is mounted on the air outflow side of the sirocco fan.
viii) The chemical volatilization method according to vi), wherein the cartridge has a disk shape and is mounted on the air inflow side of the sirocco fan.
ix) The ventilation portion provided on the side surface of the cartridge is composed of a large number of opening slits arranged side by side, and the opening slit width is 1 mm or more and 0.7 times or less the average outer diameter of the drug-impregnated body. The i) chemical volatilization method characterized by the above.
x) The granular or substantially granular drug-impregnated body has an average outer diameter of 3 mm to 10 mm, and the drug-impregnated body is filled in the cartridge with a porosity of 20% to 70%. i) Chemical volatilization method.
xi) The chemical volatilization method according to i), wherein the granular or substantially granular drug impregnated body is made of at least one selected from paper, pulp, cellulosic carrier and synthetic resin carrier.

The chemical volatilization method of the present invention is a method in which centrifugal force is applied to a granular or substantially granular drug impregnated body without heating and the chemical is volatilized and released by the generated wind force. It is possible to stably volatilize almost a constant amount of drug over a long period of time, maintain an excellent insecticidal effect unprecedented, and is excellent in safety, usability, etc. It is extremely useful for controlling unpleasant pests such as chironomids, moths, moths and cutworms, especially mosquitoes.

In addition, since the chemical volatilization method of the present invention can use a small and lightweight chemical volatilization device that operates on a dry cell, it can be applied both indoors and outdoors, for example, in a travel destination indoors or in a tent in a camp. It is very useful for the control of sanitary pests and unpleasant pests.

Furthermore, since the chemical volatilization method of the present invention can be used by replacing different cartridges containing various different drug impregnation bodies according to the purpose, a single chemical volatilization apparatus can cope with various types of harmful insects. Can be applied.

<About centrifugal force>
In the method of the present invention, centrifugal force is applied to the granular or substantially granular drug-impregnated body. In this case, the centrifugal force has various effects as exemplified below.
1) The granular or substantially granular drug-impregnated body is preliminarily filled in a suitable state (for example, a state close to closest packing), but since the individual particles are not fixed, impact is applied to the cartridge. When the cartridge is added or the cartridge is moved, the filling state of the drug-impregnated body changes because individual grains move. However, when a centrifugal force acts on the drug-impregnated body in use, the granular material is pressed in a predetermined direction by the centrifugal force, and an initial suitable filling state or a filling state close thereto is automatically reproduced.
2) When the action of the centrifugal force on the cartridge is released, each granular or substantially granular drug impregnated body in the cartridge can move freely to some extent, and its position is changed by rotation or movement. That is, with the action and release of the centrifugal force on the cartridge, the granular drug-impregnated body moves individually and exhibits the same effect as the case where it is stirred as a whole.
3) When a centrifugal force is applied to a granular or substantially granular drug-impregnated body, if the drug-impregnated body has a certain degree of flexibility, the drug-impregnated body is pressed and contracted to release the centrifugal force. Then, the drug impregnated body returns to its original size even when expanded. Therefore, the drug impregnated body repeatedly contracts and expands by repeatedly rotating (using) the cartridge and stopping (not using) the cartridge. This pump action also pushes the drug inside the drug impregnated body to the surface. As a result, the drug is effectively used.
4) Even when the granular or substantially granular drug-impregnated body is not very flexible, if a centrifugal force is applied to the drug-impregnated body, the drug inside the drug-impregnated body is pushed out to the surface by the centrifugal force, and Since it is conveyed by the wind force generated when the centrifugal force is applied, the drug inside the drug impregnated body can be used effectively.

The magnitude of the centrifugal force is appropriately selected in consideration of various conditions such as the size and shape of the cartridge and the drug impregnated body, the type of drug, and the volatilization amount. For example, the magnitude of the centrifugal force is 1/1000 to 100 times the gravity acceleration (9.8 × 10 ² cm / s ² ), specifically 9.8 × 10 ⁻¹ cm / s ^{2 to} 9.8. It may be × 10 ⁴ cm / s ² .

The drug impregnated body has a porosity of 20% to 70% in the cartridge, preferably 25% to
The filling may be 65%, particularly preferably 30% to 60%. When the porosity is less than 20%, the flow of the air flow becomes worse, so a sufficient amount of chemical volatilization cannot be ensured. On the contrary, when the porosity exceeds 70%, the air flow contacts the drug-impregnated body. Since the time to do is shortened, sufficient chemical volatilization amount cannot be secured. Therefore, the porosity is preferably selected within the above range.

By rotating the cartridge containing the drug-impregnated body, centrifugal force acts on the drug-impregnated body, and wind force generated at this time can be used. The cartridge may be rotated by, for example, a motor.

The motor can be driven by either an AC power source or a dry battery. For example, one dry battery having a voltage of 1.5 V and capable of rotating at 100 to 2000 rpm for 300 hours or more is suitable.

When the cartridge is mounted on the air outflow side and / or the air inflow side of the sirocco fan, centrifugal force acts on the drug impregnated body, and wind generated by the sirocco fan on the drug impregnated body (air flow flowing out of the sirocco fan) And / or air flow flowing into the sirocco fan), the volatilization efficiency of the drug can be increased. The cartridge may be mounted only on the air outflow side of the sirocco fan or only on the air inflow side, or may be mounted on both the air outflow side and the air inflow side of the sirocco fan. The number of cartridges attached to the sirocco fan may be one or more. For example, a plurality of cartridges can be appropriately distributed and attached to the air outflow side or the air inflow side of the sirocco fan. In this case, the plurality of cartridges may contain drug impregnated bodies impregnated with the same or different drugs.

<About drugs, drug-impregnated bodies, cartridges, etc.>
As a drug used in the present invention, a volatilizing pyrethroid insecticide capable of adjusting the volatilization amount per hour to 0.01 to 0.5 mg and exhibiting a sufficient insecticidal effect at this dose: 4 -Methoxymethyl-2,3,5,6-tetrafluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate (compound K), 4-propargyl-2,3,5,6-tetrafluorobenzyl -2,2,3,3-tetramethylcyclopropanecarboxylate (Compound L) and 2,3,5,6-tetrafluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate (Compound M) It is. One type of these compounds (drugs) may be used, or two or more types of compounds (drugs) may be used in combination.

Allethrin and praretrin used as active ingredients for heat transpiration insecticides have poor volatility under the use conditions of the present invention, while empentrin, which has the highest vapor pressure among pyrethroid insecticides, is 1 from the viewpoint of insecticidal efficacy. This is not preferable because a volatilization amount of 2 mg or more per hour is required. Therefore, in the method of the present invention, the above-mentioned compound having suitable volatility at room temperature is used.

Examples of the material of the drug-impregnated material used in the present invention include cellulose-based carriers such as paper, pulp, and viscose, synthetic resin carriers such as ethylene-vinyl acetate resin and olefin polymers, and inorganic carriers such as calcium silicate. Of these, naturally derived paper, pulp and cellulosic carriers are preferred. These are granular or substantially granular, and are preferably molded so that the average outer diameter is, for example, 3 mm to 10 mm. By adopting such a shape and size of the drug-impregnated body, the pyrethroid insecticide inside the drug-impregnated body gradually moves to the surface and can maintain a stable volatilization amount for a long period of time. . On the other hand, if the average outer diameter is smaller than 3 mm, for example, the volatilization of the drug is rapid and there may be a problem in the sustainability of the insecticidal effect.

Specific shapes of the granular or substantially granular drug-impregnated body include various shapes such as a spherical shape, an elliptical shape, an egg shape, a cylindrical shape, a prism shape, a rod shape, a disc shape, a square plate shape, an indefinite shape, and the like. The size may be various sizes. Further, various drug impregnated materials may be used in combination.

When the drug-impregnated body is stored in the cartridge, the drug-impregnated body having a specific size, shape and material may be stored in the cartridge, or various kinds of drug-impregnated bodies having different sizes, shapes and materials are suitable. They may be mixed at a proper ratio and stored in the cartridge.

Regarding drug impregnated bodies, in addition to using a combination of various kinds of drug impregnated bodies having different sizes, shapes, materials, and numbers, combining various kinds of drug impregnated bodies having different types of impregnated drugs. May be used. Moreover, it can also be used in combination such as mixing various types of drug impregnation bodies having different sizes, shapes, materials, numbers, and types of impregnated drugs. Therefore, an extremely wide variety of replaceable cartridges containing such a drug impregnated body can be obtained, and these cartridges may be used in appropriate combination depending on the application.

For example, in order to mount on the air outflow side of the sirocco fan, the cartridge preferably has an annular shape, and in order to mount on the air inflow side of the sirocco fan, the cartridge has a disk shape. Those are preferred.

In the present invention, the drug impregnated body is preferably impregnated with 100 mg or more of the aforementioned drug as a whole. If the amount of the impregnated drug is less than 100 mg, the sustainability of the insecticidal efficacy may be insufficient. In the impregnation of the chemical, a solvent, a diluent, a surfactant, a dispersant, a sustained release agent, and the like can be used as necessary, and various conventionally known impregnation means can be employed. Furthermore, a stabilizer, a fragrance, a colorant, an antistatic agent, and the like may be appropriately blended in the drug-impregnated body. In addition, as long as the volatilization performance is not hindered in the drug composition, other volatility is high. Insecticides, repellent components (for example, insecticides such as hinokitiol, carvone, safrole, citronellol, and cinnamic aldehyde), acaricides, bactericides, deodorants and the like can be added to form a multipurpose pharmaceutical composition. In addition, it is more convenient if an indicator function (for example, a discoloration function) indicating an end point of use is added to the drug-impregnated body.

Examples of a method for providing a ventilation portion in the cartridge used in the present invention include a method in which a large number of opening slits are arranged in parallel, a method in which a net is fixed to a holder that is arranged in parallel, and the like. Absent. However, in order to prevent the dissipation of the drug impregnated body while ensuring sufficient air permeability so that the condensation of the drug does not affect the volatilization performance, in the case of an open slit, the opening slit width is 1 mm or more and the drug impregnated body. The average outer diameter is preferably 0.7 times or less. The opening ratio of the total opening slit area to the side surface area of the cartridge is preferably set to, for example, 0.1 to 0.5. On the other hand, in the case of a net, the distance between the lines is, for example, 1 mm or more and the average outer diameter of the drug-impregnated body It is preferable to set it to 0.7 times or less.

The shape and size of the cartridge can be arbitrarily determined in consideration of the structure of the medicine impregnated body storage unit. As described above, it is preferable to mount the cartridge on the air outflow side and / or the air inflow side of the sirocco fan.

Other than those using sirocco fans, for example, a cylindrical cartridge with an outer diameter of 3 to 6 cm and a height of about 2 to 5 cm is easy to use. For example, the central axis of the cartridge is hollow. If the hollow portion is shaped so as to fit into the rotation shaft of the main body, it is easy to load the cartridge into the chemical volatilization apparatus main body. In addition, the cartridge may have a substantially conical shape, or may be a type that is loaded into a device having a rotation shaft provided in the lateral direction.

A protective cover such as a slit shape or a mesh shape is attached around the cartridge so that fingers or the like do not touch the rotating cartridge. You may give the function of the said protective cover to some chemical volatilization apparatuses which accommodate the said cartridge. Before use, it is preferable to attach a shielding member (for example, a seal tape) to the ventilation portion of the cartridge in order to prevent the chemical from evaporating from the drug-impregnated body accommodated in the cartridge. The shielding member may be peeled off immediately before use. Use of an adhesive tape as the sealing tape is convenient because it can be easily peeled off. The slit bar portion of the cartridge and the slit bar portion of the protective cover may have a twist angle suitable for a blade shape in order to improve the draft.

A cartridge in which the granular or substantially granular drug-impregnated body has an average outer diameter of 3 mm to 10 mm and the drug-impregnated body is filled in the cartridge with a porosity of 20% to 70% is easy to use, In addition, it is possible to stably volatilize a substantially constant amount of drug over a long period of time, which is particularly preferable for practical use.

The material of the granular or substantially granular drug-impregnated body is not particularly limited. For example, a material composed of at least one selected from paper, pulp, cellulosic carrier and synthetic resin carrier (a single material or a combination of these materials) ) Is preferable as a material constituting the granular or substantially granular drug-impregnated body.

The present invention will be described more specifically with reference to the following examples and test examples. However, the examples and test examples are merely for the purpose of explanation, and the present invention is not limited thereto.

Examples 1-2:
Hereinafter, an example in which a cartridge containing a granular or substantially granular drug impregnated body is mounted on the air outflow side and / or the air inflow side of a sirocco fan will be described.
A) Sirocco Fan FIG. 4 shows a schematic configuration diagram of an example of a sirocco fan. 4A is a top view, FIG. 4B is a side sectional view of FIG. 4A taken along line AA, and FIG. 4C is a bottom view. The sirocco fan 12 is provided with wing portions 13 (slightly curved) protruding inward at regular intervals along the inner periphery of a plastic cylinder, for example, and an opening slit 4 is provided between the wing portions 13. (Not shown) is provided. A motor mounting portion 15 supported by four arm portions 14 is provided at the center of the sirocco fan 12. When the sirocco fan 12 is rotated by the motor, the air flowing from the upper surface side of the sirocco fan 12 flows out through the opening slit 4 due to the wind force generated by the wing part 13.
B) Preparation of cartridge (Example 1)
An example of the cartridge mounted on the air inflow side of the sirocco fan 12 is shown. 350 mg of compound K [4-methoxymethyl-2,3,5,6-tetrafluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate] was added to granular expanded cellulose beads having an average outer diameter of about 5 mm [ Product name: Visco Pearl (manufactured by Rengo Co., Ltd.)] The drug impregnated body 1 obtained by impregnating 3 g was stored in the drug impregnated body storage section 3 of the disc-shaped cartridge 2 having an outer diameter of 3 cm and a height of 1 cm. The internal volume of the disc-shaped cartridge 2 is 40 cm ³ , and the porosity (ratio of the internal volume remaining as a void without being filled with the drug impregnated body,%) is 45%. The disk-like cartridge 2 is provided with opening slits 4 (not shown) having a width of approximately 2 mm in the height direction on the side surface every 3 mm (pitch interval).
FIG. 2 is a side cross-sectional view of the disk-shaped cartridge 2 according to the first embodiment mounted on the air inflow side of the sirocco fan 12. Since the centrifugal force does not act or hardly acts at the center of the disc-shaped cartridge 2 and its vicinity when the disc-shaped cartridge 2 is rotated, the drug impregnated body 1 is not stored and left as a gap.
FIG. 3 shows the disc-like cartridge 2 of Example 1 in a state where the drug impregnated body 1 is not accommodated. 3A is a top view of the disk-shaped cartridge 2, and FIG. 3B is a side sectional view of the disk-shaped cartridge 2 when FIG. 3A is cut along the line AA. is there. As shown in FIG. 3A, a large number of opening slits 4 such as wedges or rectangles are provided on the upper surface of the disk-shaped cartridge 2.
As shown in FIG. 2, in order to attach the disc-shaped cartridge 2 of Example 1 to the air inflow side of the sirocco fan 12, a holding portion (for holding the disc-shaped cartridge 2 on the air inflow side of the sirocco fan 12 ( For example, a cover part) is required. FIG. 5 shows an example of the lid. 5A is a top view of the lid portion 16, FIG. 5B is a side view of the lid portion 16, and FIG. 5C is a state where the lid portion 16 is mounted on the disc-shaped cartridge 2 of the first embodiment. It is side part sectional drawing shown. Similarly to the upper surface of the disc-shaped cartridge 2, the lid 16 is also provided with a large number of opening slits 4 such as a wedge shape or a rectangle.
C) Chemical volatilization device 1
In FIG. 1, an example of the chemical volatilization apparatus provided with the sirocco fan 12 which mounted | wore with the disk shaped cartridge 2 of Example 1 is shown. 1A is a top view of the drug volatilization apparatus, FIG. 1B is a side sectional view of the drug volatilization apparatus, and FIG. 1C is a bottom view of the drug volatilization apparatus. This chemical volatilization device is small and light as a whole and can be easily carried. Moreover, since it operates with the dry battery 8, it can also be used outdoors, for example, in a tent.
D) Preparation of cartridge (Example 2)
An example of the cartridge mounted on the air outflow side of the sirocco fan 12 is shown. Compound L [4-propargyl-2,3,5,6-tetrafluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate] 300 mg, granular expanded cellulose beads having an average outer diameter of about 5 mm [Products Name: Bisco Pearl (manufactured by Rengo Co., Ltd.)] The drug impregnated body 1 obtained by impregnating 3 g is stored in the drug impregnated body storage section 3 of the annular cartridge 2 having an outer diameter of 6.5 cm, an inner diameter of 4 cm and a height of 2 cm. did. The internal volume of the annular cartridge 2 is 40 cm ³ and the porosity is 45%. The annular cartridge 2 is provided with opening slits 4 (not shown) having a width of approximately 2 mm in the height direction on the side surface every 3 mm.
FIG. 6 shows a state where the annular cartridge 2 of the second embodiment is mounted on the air outflow side of the sirocco fan 12 and the motor 9 is mounted on the sirocco fan 12.
E) Chemical volatilization device 2
In FIG. 7, an example of the chemical volatilization apparatus provided with the sirocco fan 12 which mounted | wore with the annular cartridge 2 of Example 2 is shown. 7A is a top view of the drug volatilization apparatus, FIG. 7B is a side sectional view of the drug volatilization apparatus, and FIG. 7C is a bottom view of the drug volatilization apparatus. Since the annular cartridge 2 is mounted on the air outflow side (outer peripheral part) of the sirocco fan 12, the centrifugal force and wind force accompanying the rotation of the sirocco fan 12 acts effectively, and the volatilization efficiency of the medicine is very good.

Test Example 1: (including Examples 1-2 and Comparative Examples 1-4)
In addition to the drug-impregnated bodies of Examples 1 and 2, according to Example 2, various drug-impregnated bodies (Comparative Examples 1 to 4) shown in Table 1 below were prepared. This is housed in the same cartridge as in Example 2 (cartridge in FIG. 6), and the cartridge is mounted on the chemical volatilization apparatus in FIG. 7 and used for 12 hours a day. On the 30th day, a chemical volatilization amount measurement and an insecticidal efficacy test by the following test method (continuous aeration method) were performed. The results are also shown in Table 1 below.
In addition, the insecticidal efficacy is the initial overturning effect when the mosquito-repellent mat containing dl, d-cis, trans-areslin (pinamin forte) is transpired at a heating element heat sink temperature of 160 ° C. As a relative effective ratio.

Test method (continuous ventilation method)
A plastic cylinder with an inner diameter of 20 cm and a height of 43 cm is stacked in two stages, and a cylinder (place where the test mosquito is placed) with an inner diameter and a height of 20 cm both divided by a 16 mesh wire mesh is placed on it. A cylinder with a height of 20 cm and a height of 20 cm is placed. This four-tiered cylinder is placed on a table, and a chemical volatilization device is placed at the center of the table (in the lowermost cylinder) to volatilize the insecticidal components in the drug-impregnated body. Then, about 20 test mosquitoes are released into the second-stage cylinder from the top, and the number of the test mosquitoes overturned over time is observed. 20 minutes after exposure, all test mosquitoes are transferred to a clean polyethylene container, given 3% sugar water, and examined for mortality 24 hours after storage.

注）化合物Ａ：２，３，５，６−テトラフルオロベンジル−クリサンテマート

Note) Compound A: 2,3,5,6-tetrafluorobenzyl-chrysanthemate

Further, according to Example 2, a drug impregnated product (Example 3) containing 2,3,5,6-tetrafluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate (Compound M) was prepared. The same evaluation was performed. The results are shown in Table 2 below.

As shown in Table 1 and Table 2, according to the chemical volatilization method of the present invention, it was confirmed that the volatilization amount of the chemical was stable over a long period of 30 days, and high insecticidal efficacy was maintained during this period. That is, when the chemical volatilization apparatus of FIG. 1 provided with the type 1 cartridge, particularly the chemical volatilization apparatus of FIG. 7 provided with the type 2 cartridge, there is almost no change over time in the volatilization amount. It can be seen that the insecticidal effect is almost constant over the day and has excellent temporal stability.

On the other hand, when the impregnation amount of the drug is less than 100 mg as in Comparative Example 1, the sustainability of the insecticidal efficacy is insufficient, and when the particle diameter of the drug impregnated body is smaller than 3 mm as in Comparative Example 2. However, the volatilization amount decreased with time, and stable volatilization performance could not be achieved. Furthermore, as in Comparative Example 3, when a conventional pyrethroid for removing electric mosquitoes such as dl, d-cis, trans-arethrin (pinamin forte) is used as a drug, this drug is almost normal at normal temperature in wind power accompanying centrifugal force. Volatilization did not occur. Furthermore, as in Comparative Example 4, when empentrin having a high vapor pressure is used as a drug, it is difficult to adjust the volatilization performance of the drug, and the basic insecticidal activity against mosquitoes is low. Did not play.

It is a figure which shows an example of the chemical | medical agent chemical volatilization apparatus provided with the sirocco fan which mounted | wore the cartridge of Example 1. FIG. FIG. 3 is a side cross-sectional view showing a state where the cartridge of Example 1 is mounted on the air inflow side of the sirocco fan. It is a figure which shows the cartridge of Example 1 of the state which does not accommodate a chemical | medical agent impregnation body. It is a schematic block diagram of an example of the sirocco fan used with the method of this invention. It is a figure which shows the state which mounted | wore with the cover part used when attaching the cartridge of Example 1 to a sirocco fan, and the said cover part to the cartridge of Example 1. FIG. It is a figure which shows the state which mounts the cartridge of Example 2 in the air outflow side of a sirocco fan, and also mounts a motor on a sirocco fan. It is a figure which shows an example of the chemical | medical agent volatilization apparatus provided with the sirocco fan equipped with the cartridge of Example 2.

Explanation of symbols

1: Drug impregnated body, 2: Cartridge, 3: Drug impregnated body storage part, 4: Opening slit 5: Chemical volatilization device main body, 6: Rotating shaft part, 7: Protective cover, 8: Dry cell, 9: Motor 10: Holder , 11: net, 12: sirocco fan, 13: wing, 14: arm, 15: motor mounting, 16: lid

Claims (11)

A granular or substantially granular drug impregnated body is housed in a cartridge having a vent on the side surface, and the drug impregnated body is volatilized under a situation in which centrifugal force acts on the drug impregnated body by rotation of the cartridge. A chemical volatilization method, wherein an average outer diameter of the granular or substantially granular drug-impregnated body is 3 mm to 10 mm, and the drug-impregnated body is impregnated with 100 mg or more of the drug as a whole. The drug is volatilized in an amount of 0.01 to 0.5 mg per hour and can be volatilized for 180 hours or more, and the drug has the following group: 4-methoxymethyl-2,3,5, 6-tetrafluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate (compound K), 4-propargyl-2,3,5,6-tetra Fluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate (Compound L) and 2,3,5,6-tetrafluorobenzyl-2,2,3,3-tetramethylcyclopropanecarboxylate (Compound M) A chemical volatilization method comprising at least one compound selected from The chemical volatilization method according to claim 1, wherein the centrifugal force is 9.8 × 10 ⁻¹ cm / s ^{2 to} 9.8 × 10 ⁴ cm / s ² . The drug volatilization method according to claim 1, wherein the drug impregnated body is filled in the cartridge with a porosity of 20% to 70%. The drug volatilization method according to claim 1, wherein the cartridge is rotated by a motor. The drug volatilization method according to claim 4, wherein the rotation speed of the motor is 100 to 2000 rpm. The drug volatilization method according to claim 1, wherein the cartridge is mounted on an air outflow side and / or an air inflow side of the sirocco fan. The chemical volatilization method according to claim 6, wherein the cartridge has an annular shape, and the cartridge is mounted on an air outflow side of the sirocco fan. The drug volatilization method according to claim 6, wherein the cartridge has a disk shape, and the cartridge is mounted on the air inflow side of the sirocco fan. The ventilation portion provided on the side surface of the cartridge is composed of a large number of opening slits arranged side by side, and the opening slit width is 1 mm or more and 0.7 times or less the average outer diameter of the drug-impregnated body. The chemical volatilization method according to claim 1. The average outer diameter of the granular or substantially granular drug-impregnated body is 3 mm to 10 mm, and the drug-impregnated body is filled with a porosity of 20% to 70% in the cartridge. The method of volatilizing a drug according to 1. The drug volatilization method according to claim 1, wherein the granular or substantially granular drug-impregnated body is made of at least one selected from paper, pulp, cellulosic carrier and synthetic resin carrier.

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