JP2003524582A - 抗高脂血症性スタチン−Ｌｐ（ａ）阻害剤配合物 - Google Patents
抗高脂血症性スタチン−Ｌｐ（ａ）阻害剤配合物Info
- Publication number
- JP2003524582A JP2003524582A JP2000538689A JP2000538689A JP2003524582A JP 2003524582 A JP2003524582 A JP 2003524582A JP 2000538689 A JP2000538689 A JP 2000538689A JP 2000538689 A JP2000538689 A JP 2000538689A JP 2003524582 A JP2003524582 A JP 2003524582A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- pharmaceutical composition
- statin
- acceptable salt
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6943297P | 1997-12-12 | 1997-12-12 | |
| US60/069,432 | 1997-12-12 | ||
| PCT/US1998/023480 WO1999030706A1 (en) | 1997-12-12 | 1998-11-04 | ANTIHYPERLIPIDEMIC STATIN-LP(a) INHIBITOR COMBINATIONS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003524582A true JP2003524582A (ja) | 2003-08-19 |
| JP2003524582A5 JP2003524582A5 (xx) | 2006-01-05 |
Family
ID=22088939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000538689A Pending JP2003524582A (ja) | 1997-12-12 | 1998-11-04 | 抗高脂血症性スタチン−Ｌｐ（ａ）阻害剤配合物 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1037623A1 (xx) |
| JP (1) | JP2003524582A (xx) |
| KR (1) | KR20010033017A (xx) |
| AU (2) | AU1306099A (xx) |
| BR (1) | BR9813539A (xx) |
| CA (1) | CA2299397A1 (xx) |
| HU (1) | HUP0100349A3 (xx) |
| IL (1) | IL134364A0 (xx) |
| IS (1) | IS5385A (xx) |
| NO (1) | NO20002965D0 (xx) |
| NZ (1) | NZ502874A (xx) |
| PL (1) | PL343851A1 (xx) |
| WO (1) | WO1999030706A1 (xx) |
| ZA (1) | ZA9811349B (xx) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4798814B2 (ja) | 1997-01-07 | 2011-10-19 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 食物摂取低減用のエキセンジンおよびそのアゴニストの使用 |
| EP1076091A1 (en) * | 1999-08-09 | 2001-02-14 | Universite Catholique De Louvain | Medicament for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour and wounds |
| CA2396157A1 (en) * | 2000-01-10 | 2001-07-19 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for modulation of triglyceride levels and treatment of dyslipidemia |
| WO2001058443A1 (en) * | 2000-02-10 | 2001-08-16 | Takeda Chemical Industries, Ltd. | TNF- α INHIBITORS |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0320226A (ja) * | 1989-06-05 | 1991-01-29 | E R Squibb & Sons Inc | 末梢血管動脈硬化症治療剤 |
| WO1993013801A1 (en) * | 1992-01-17 | 1993-07-22 | The Procter & Gamble Company | Treatment for atherosclerosis |
| WO1996030328A1 (en) * | 1995-03-24 | 1996-10-03 | Warner-Lambert Company | Terminal carboxy or tetrazole groups containing dialkyl ethers |
| WO1997038694A1 (en) * | 1996-04-17 | 1997-10-23 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardiovascular disease |
| JP2002508320A (ja) * | 1997-12-12 | 2002-03-19 | ワーナー−ランバート・カンパニー | スタチン−カルボキシアルキルエーテル配合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4275793A (en) * | 1992-02-25 | 1993-09-13 | Warner-Lambert Company | Cytoprotective compositions containing pyruvate and antioxidants |
| US5720963A (en) * | 1994-08-26 | 1998-02-24 | Mary Kay Inc. | Barrier disruption treatments for structurally deteriorated skin |
| EP0738510A3 (fr) * | 1995-04-20 | 2005-12-21 | L'oreal | Utilisation d'un inhibiteur d'HMG-coenzyme A-reductase pour lutter contre le vieillissement de la peau et pour traiter l'acné. Composition comprenant au moins un inhibiteur HMG-coenzyme A reductase et au moins un actif possédant des propriétes desquamantes |
-
1998
- 1998-11-04 JP JP2000538689A patent/JP2003524582A/ja active Pending
- 1998-11-04 KR KR1020007006370A patent/KR20010033017A/ko not_active Application Discontinuation
- 1998-11-04 WO PCT/US1998/023480 patent/WO1999030706A1/en not_active Application Discontinuation
- 1998-11-04 AU AU13060/99A patent/AU1306099A/en not_active Abandoned
- 1998-11-04 EP EP98956562A patent/EP1037623A1/en not_active Ceased
- 1998-11-04 HU HU0100349A patent/HUP0100349A3/hu unknown
- 1998-11-04 PL PL98343851A patent/PL343851A1/xx unknown
- 1998-11-04 IL IL13436498A patent/IL134364A0/xx unknown
- 1998-11-04 NZ NZ502874A patent/NZ502874A/en unknown
- 1998-11-04 BR BR9813539-2A patent/BR9813539A/pt not_active Application Discontinuation
- 1998-11-04 CA CA002299397A patent/CA2299397A1/en not_active Abandoned
- 1998-12-10 ZA ZA9811349A patent/ZA9811349B/xx unknown
-
2000
- 2000-02-25 IS IS5385A patent/IS5385A/is unknown
- 2000-06-09 NO NO20002965A patent/NO20002965D0/no not_active Application Discontinuation
-
2003
- 2003-08-29 AU AU2003244047A patent/AU2003244047A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0320226A (ja) * | 1989-06-05 | 1991-01-29 | E R Squibb & Sons Inc | 末梢血管動脈硬化症治療剤 |
| WO1993013801A1 (en) * | 1992-01-17 | 1993-07-22 | The Procter & Gamble Company | Treatment for atherosclerosis |
| WO1996030328A1 (en) * | 1995-03-24 | 1996-10-03 | Warner-Lambert Company | Terminal carboxy or tetrazole groups containing dialkyl ethers |
| WO1997038694A1 (en) * | 1996-04-17 | 1997-10-23 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardiovascular disease |
| JP2002508320A (ja) * | 1997-12-12 | 2002-03-19 | ワーナー−ランバート・カンパニー | スタチン−カルボキシアルキルエーテル配合物 |
Non-Patent Citations (8)
| Title |
|---|
| GLUECK C.J.: "Gemfibrozil-Lovastatin Therapy for primary Hyperlipoproteminas", THE AMERICAN JOURNAL OF CARDIOLOGY, vol. 70, no. 1, JPNX006017901, 1992, pages 1 - 9, XP023279550, ISSN: 0000732010, DOI: 10.1016/0002-9149(92)91380-M * |
| GRUNDY S.M.: "Atherogenic Dyslipidemia: Lipoprotein Abnormalities and Implications for Therapy", THE AMERICAN JOURNAL OF CARDIOLOGY, vol. 75, JPNX006017899, 1995, pages 45 - 52, ISSN: 0000732008 * |
| HEINONEN T.M.: "Atorvastatin, a New HGM-CoA Reductase Inhibitor as Monotherapy and Combined With Colestipol", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, vol. 1, no. 2, JPNX006017903, 1996, pages 117 - 122, XP000618614, ISSN: 0000732012 * |
| ILLINGWORTH D.R.: "Comparative Effects of Lovastatin and Niacin in Primary Hypercholestedolrmia", ARCHIVES OF INTERNAL MEDICINE, vol. 154, no. 14, JPNX006017900, 1994, pages 1586 - 1595, ISSN: 0000732009 * |
| JONES P.H.: "Effect of gemfibrozil on level of lipoprotein[a] in Type II hyperlipoproteinemic subjects", JOURNAL OF LIPID RESEARCH, vol. 37, JPNX006017902, 1996, pages 1298 - 1308, ISSN: 0000732011 * |
| RAMHARACK R.: "Retinoids Inhibit Primary Cynomolgus Monkey Hepatocyte Lipoprotein(a) Levels", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 238, no. 1, JPNX006017905, 1997, pages 48 - 52, XP002103071, ISSN: 0000732014, DOI: 10.1006/bbrc.1997.7240 * |
| SHIOMI M.: "Suppression of established athrosclerosis and xabthomas in mature WHHL rabbits by keeping their seru", ATHEROSCLEROSIS, vol. 83, JPNX006017904, 1990, pages 69 - 80, ISSN: 0000732013 * |
| STONE N.J.: "Lipid Management: Current Diet and Drug Treatment Options", THE AMERICAN JOURNAL OF MEDICINE, vol. Vol.101 (suppl 4A), JPNX006017898, 1996, pages 4 - 40, ISSN: 0000732007 * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR9813539A (pt) | 2000-10-10 |
| AU2003244047A1 (en) | 2003-09-25 |
| WO1999030706A1 (en) | 1999-06-24 |
| NO20002965L (no) | 2000-06-09 |
| ZA9811349B (en) | 1999-06-14 |
| EP1037623A1 (en) | 2000-09-27 |
| AU1306099A (en) | 1999-07-05 |
| PL343851A1 (en) | 2001-09-10 |
| NO20002965D0 (no) | 2000-06-09 |
| HUP0100349A3 (en) | 2002-02-28 |
| NZ502874A (en) | 2004-03-26 |
| IL134364A0 (en) | 2001-04-30 |
| CA2299397A1 (en) | 1999-06-24 |
| HUP0100349A2 (hu) | 2001-07-30 |
| KR20010033017A (ko) | 2001-04-25 |
| IS5385A (is) | 2000-02-25 |
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