JP2003513256A5 - - Google Patents
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- JP2003513256A5 JP2003513256A5 JP2001534489A JP2001534489A JP2003513256A5 JP 2003513256 A5 JP2003513256 A5 JP 2003513256A5 JP 2001534489 A JP2001534489 A JP 2001534489A JP 2001534489 A JP2001534489 A JP 2001534489A JP 2003513256 A5 JP2003513256 A5 JP 2003513256A5
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- JP
- Japan
- Prior art keywords
- composition
- equivalents
- acid
- polyester composition
- diol component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 description 31
- 239000002253 acid Substances 0.000 description 19
- 229920000728 polyester Polymers 0.000 description 13
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 12
- 150000002009 diols Chemical class 0.000 description 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 8
- 125000001931 aliphatic group Chemical group 0.000 description 6
- AMOKUAKXKXBFIW-WJDWOHSUSA-N 9-[(Z)-non-3-enyl]-10-octylnonadecanedioic acid Chemical compound OC(=O)CCCCCCCCC(CCCCCCCC)C(CCCCCCCC(O)=O)CC\C=C/CCCCC AMOKUAKXKXBFIW-WJDWOHSUSA-N 0.000 description 4
- 210000004369 Blood Anatomy 0.000 description 4
- QQVIHTHCMHWDBS-UHFFFAOYSA-N Isophthalic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 description 4
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Chemical compound C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 description 4
- 210000002381 Plasma Anatomy 0.000 description 4
- 210000002966 Serum Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 230000001413 cellular Effects 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- SLCVBVWXLSEKPL-UHFFFAOYSA-N 2,2-dimethylpropane-1,3-diol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 3
- 229940117969 NEOPENTYL GLYCOL Drugs 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N Triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 2
- 230000000397 acetylating Effects 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 125000004432 carbon atoms Chemical group C* 0.000 description 2
- QVQDALFNSIKMBH-UHFFFAOYSA-N 2-pentoxyethanol Chemical compound CCCCCOCCO QVQDALFNSIKMBH-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
Description
【特許請求の範囲】
【請求項１】
血液の細胞部分からの血清または血漿の分離の容易化に使用するためのポリエステル組成物であって、
（ａ）（i）ベンゼンポリカルボン酸、およびその誘導体、および
（ii）約１６〜約４０個の炭素原子を有する脂肪族ポリカルボン酸
を含む多官能基酸成分、ならびに
（ｂ）ジオール成分
を含んでなり、かつ前記多官能基酸成分とジオール成分が約０．８：１．１〜約１．０：１．３５の範囲の当量比で使用される組成物。
【請求項２】
前記ベンゼンポリカルボン酸が約０．５１〜約０．８５当量の量で使用される、請求項１に記載の組成物。
【請求項３】
前記ベンゼンポリカルボン酸が、無水フタル酸、イソフタル酸、およびその混合物から成る群から選択される、請求項１に記載の組成物。
【請求項４】
前記脂肪族ポリカルボン酸が約０．１７〜約０．５６当量の量で使用される、請求項１に記載の組成物。
【請求項５】
前記脂肪族ポリカルボン酸がＣ36二量体酸である、請求項１に記載の組成物。
【請求項６】
前記ジオール成分が約１．０〜約１．３５当量の量で使用される、請求項１に記載の組成物。
【請求項７】
前記ジオール成分が、ネオペンチルグリコール、プロピレングリコール、トリエチレングリコールおよびそれらの混合物から成る群から選択される、請求項１に記載の組成物。
【請求項８】
前記多官能基酸成分とジオール成分が、約１．０：１．２の当量比で使用される、請求項１に記載の組成物。
【請求項９】
前記ポリエステル組成物が、約１５〜約７０の残留ヒドロキシル価を有する、請求項１に記載の組成物。
【請求項１０】
前記ポリエステル組成物が、約５以下の残留ヒドロキシル価を有する、請求項１に記載の組成物。
【請求項１１】
血液の細胞部分からの血清または血漿の分離の容易化に使用するためのポリエステル組成物であって、
（ａ）（i）約０．３当量の無水フタル酸、
（ii）約０．３当量のイソフタル酸、および
（iii）約０．３当量のＣ36二量体酸
を含む多官能基酸成分、ならびに
（ｂ）（iv）約０．９当量のネオペンチルグリコール、および
（v）約０．３当量のプロピレングリコール
を含むジオール成分
を含んでなる組成物。
【請求項１２】
前記ポリエステル組成物が、約１５〜約７０の残留ヒドロキシル価を有する、請求項１１に記載の組成物。
【請求項１３】
前記ポリエステル組成物が、約５以下の残留ヒドロキシル価を有する、請求項１１に記載の組成物。
【請求項１４】
血液の細胞部分からの血清または血漿の分離の容易化に使用するためのポリエステル組成物の製造方法であって、
（ａ）（i）ベンゼンポリカルボン酸、およびその誘導体、および
（ii）約１６〜約４０個の炭素原子を有する脂肪族ポリカルボン酸、
を含む多官能基酸成分を供給すること、
（ｂ）ジオール成分を供給すること、ならびに
（ｃ）前記ポリエステル組成物を形成するために、約０．８：１．１〜約１．０：１．３５の範囲の当量比で（ａ）と（ｂ）を反応させること
を含んでなる製造方法。
【請求項１５】
前記ベンゼンポリカルボン酸が約０．５１〜約０．８５当量の量で使用される、請求項１４に記載の製造方法。
【請求項１６】
前記ベンゼンポリカルボン酸が、無水フタル酸、イソフタル酸、およびその混合物から成る群から選択される、請求項１４に記載の製造方法。
【請求項１７】
前記脂肪族ポリカルボン酸が約０．１５〜約０．４９当量の量で使用される、請求項１４に記載の製造方法。
【請求項１８】
前記脂肪族ポリカルボン酸がＣ36二量体酸である、請求項１４に記載の組成物。
【請求項１９】
前記ジオール成分が約１．１〜約１．３５当量の量で使用される、請求項１４に記載の製造方法。
【請求項２０】
前記ジオール成分が、ネオペンチルグリコール、プロピレングリコール、トリエチレングリコールおよびそれらの混合物から成る群から選択される、請求項１４に記載の製造方法。
【請求項２１】
前記多官能基酸成分およびジオール成分が、約１．０：１．２の当量比で使用される、請求項１４に記載の製造方法。
【請求項２２】
前記ポリエステル組成物が、約１５〜約７０の残留ヒドロキシル価を有する、請求項１４に記載の製造方法。
【請求項２３】
さらに、前記ポリエステル組成物を約５以下の残留ヒドロキシル価にアセチル化することを含む、請求項１４に記載の製造方法。
【請求項２４】
血液の細胞部分からの血清または血漿の分離の容易化に使用するためのポリエステル組成物の製造方法であって、
（ａ）（i）約０．３当量の無水フタル酸、
（ii）約０．３当量のイソフタル酸、および
（iii）約０．３当量のＣ36二量体酸
を含む多官能基酸成分を供給すること、
（ｂ）（iv）約０．９当量のネオペンチルグリコール、および
（v）約０．３当量のプロピレングリコール
を含むジオール成分を供給すること、ならびに
（ｃ）約１５〜約７０の残留ヒドロキシル価を有するポリエステル組成物を作製するために（ａ）および（ｂ）を反応させること
を含んでなる製造方法。
【請求項２５】
さらに、前記ポリエステル組成物を約５以下の残留ヒドロキシル価にアセチル化することを含む、請求項２４に記載の製造方法。
【請求項２６】
請求項１４〜２５のいずれか１項に記載の製造方法の生成物。
[Claims]
(1)
A polyester composition for use in facilitating the separation of serum or plasma from a cellular portion of blood, comprising:
(A) a polyfunctional acid component comprising (i) a benzene polycarboxylic acid and its derivatives, and (ii) an aliphatic polycarboxylic acid having from about 16 to about 40 carbon atoms; and (b) a diol component. A composition comprising the multifunctional acid component and the diol component in an equivalent ratio ranging from about 0.8: 1.1 to about 1.0: 1.35.
(2)
The composition of claim 1, wherein said benzene polycarboxylic acid is used in an amount of about 0.51 to about 0.85 equivalents.
(3)
The composition of claim 1, wherein the benzene polycarboxylic acid is selected from the group consisting of phthalic anhydride, isophthalic acid, and mixtures thereof.
(4)
The composition of claim 1, wherein the aliphatic polycarboxylic acid is used in an amount from about 0.17 to about 0.56 equivalents.
(5)
The aliphatic polycarboxylic acid is a C 36 dimer acid composition of claim 1.
6.
The composition of claim 1, wherein the diol component is used in an amount from about 1.0 to about 1.35 equivalents.
7.
The composition of claim 1, wherein the diol component is selected from the group consisting of neopentyl glycol, propylene glycol, triethylene glycol, and mixtures thereof.
Claim 8.
The composition of claim 1, wherein the polyfunctional acid component and the diol component are used in an equivalent ratio of about 1.0: 1.2.
9.
The composition of claim 1, wherein the polyester composition has a residual hydroxyl number from about 15 to about 70.
10.
The composition of claim 1, wherein the polyester composition has a residual hydroxyl number of about 5 or less.
11.
A polyester composition for use in facilitating the separation of serum or plasma from a cellular portion of blood, comprising:
(A) (i) about 0.3 equivalents of phthalic anhydride;
(Ii) a polyfunctional acid component comprising about 0.3 equivalents of isophthalic acid, and (iii) about 0.3 equivalents of C 36 dimer acid; and (b) (iv) about 0.9 equivalents of neo A composition comprising pentyl glycol, and (v) a diol component comprising about 0.3 equivalents of propylene glycol.
12.
The composition of claim 11, wherein the polyester composition has a residual hydroxyl number from about 15 to about 70.
Claim 13
The composition of claim 11, wherein the polyester composition has a residual hydroxyl number of about 5 or less.
14.
A method for producing a polyester composition for use in facilitating the separation of serum or plasma from cellular parts of blood, comprising:
(A) (i) benzene polycarboxylic acids and derivatives thereof, and (ii) aliphatic polycarboxylic acids having about 16 to about 40 carbon atoms;
Supplying a polyfunctional acid component containing
(B) providing a diol component; and (c) providing an equivalent ratio ranging from about 0.8: 1.1 to about 1.0: 1.35 to form the polyester composition. And (b).
15.
15. The method of claim 14, wherein said benzene polycarboxylic acid is used in an amount of about 0.51 to about 0.85 equivalents.
16.
The method according to claim 14, wherein the benzene polycarboxylic acid is selected from the group consisting of phthalic anhydride, isophthalic acid, and mixtures thereof.
17.
15. The method of claim 14, wherein said aliphatic polycarboxylic acid is used in an amount of about 0.15 to about 0.49 equivalents.
18.
The aliphatic polycarboxylic acid is a C 36 dimer acid composition of claim 14.
(19)
15. The method of claim 14, wherein said diol component is used in an amount of about 1.1 to about 1.35 equivalents.
20.
The method according to claim 14, wherein the diol component is selected from the group consisting of neopentyl glycol, propylene glycol, triethylene glycol and mixtures thereof.
21.
The method according to claim 14, wherein the polyfunctional acid component and the diol component are used in an equivalent ratio of about 1.0: 1.2.
22.
The method of claim 14, wherein the polyester composition has a residual hydroxyl number from about 15 to about 70.
23.
15. The method of claim 14, further comprising acetylating the polyester composition to a residual hydroxyl number of about 5 or less.
24.
A method for producing a polyester composition for use in facilitating the separation of serum or plasma from cellular parts of blood, comprising:
(A) (i) about 0.3 equivalents of phthalic anhydride;
Providing a polyfunctional acid component comprising (ii) about 0.3 equivalents of isophthalic acid, and (iii) about 0.3 equivalents of C 36 dimer acid.
Providing (b) (iv) a diol component comprising about 0.9 equivalents of neopentyl glycol; and (v) about 0.3 equivalents of propylene glycol; and (c) a residual hydroxyl number of about 15 to about 70. A process comprising reacting (a) and (b) to produce a polyester composition having the formula:
25.
25. The method of claim 24, further comprising acetylating the polyester composition to a residual hydroxyl number of about 5 or less.
26.
A product of the production method according to any one of claims 14 to 25.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/433,164 US6072022A (en) | 1999-11-03 | 1999-11-03 | Physiological fluid separation vehicles having improved resistance to inward migration of therapeutic agents |
| US09/433,164 | 1999-11-03 | ||
| PCT/US2000/027226 WO2001032290A1 (en) | 1999-11-03 | 2000-10-03 | Physiological fluid separation vehicles having improved resistance to inward migration of therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003513256A JP2003513256A (en) | 2003-04-08 |
| JP2003513256A5 true JP2003513256A5 (en) | 2008-03-27 |
Family
ID=23719077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001534489A Pending JP2003513256A (en) | 1999-11-03 | 2000-10-03 | Physiological liquid separation excipients with improved resistance to internal migration of therapeutic agents |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6072022A (en) |
| EP (1) | EP1246678B1 (en) |
| JP (1) | JP2003513256A (en) |
| CN (1) | CN1387456A (en) |
| AT (1) | ATE312656T1 (en) |
| AU (1) | AU7749500A (en) |
| CA (1) | CA2389746C (en) |
| DE (1) | DE60024873D1 (en) |
| WO (1) | WO2001032290A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1409566B1 (en) * | 2001-06-28 | 2008-04-23 | Wm. MARSH RICE UNIVERSITY | Photocrosslinking of diethyl fumarate/poly(propylene fumarate) biomaterials |
| US7629388B2 (en) * | 2001-11-20 | 2009-12-08 | William Marsh Rice University | Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion |
| US7673758B2 (en) | 2005-08-10 | 2010-03-09 | The Regents Of The University Of California | Collection tubes apparatus, systems, and methods |
| US7971730B2 (en) | 2005-08-10 | 2011-07-05 | The Regents Of The University Of California | Collection tubes apparatus, systems and methods |
| US7674388B2 (en) * | 2005-08-10 | 2010-03-09 | The Regents Of The University Of California | Photopolymer serum separator |
| US9248447B2 (en) * | 2005-08-10 | 2016-02-02 | The Regents Of The University Of California | Polymers for use in centrifugal separation of liquids |
| US9669405B2 (en) | 2012-10-22 | 2017-06-06 | The Regents Of The University Of California | Sterilizable photopolymer serum separator |
| TWI547374B (en) * | 2015-04-24 | 2016-09-01 | 長興材料工業股份有限公司 | Hydrophilic film for ex vivo membrane |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3235520A (en) * | 1960-06-27 | 1966-02-15 | United Shoe Machinery Corp | Resinous non-tacky thermoplastic adhesive comprising resinous linear terpolyester of a linear glycol and acid components |
| GB1035999A (en) * | 1963-06-14 | 1966-07-13 | British Nylon Spinners Ltd | Improvements in or relating to the manufacture of synthetic polyesters |
| US3954689A (en) * | 1973-12-10 | 1976-05-04 | E. I. Du Pont De Nemours And Company | Segmented thermoplastic copolyester elastomers |
| US4101422A (en) * | 1977-05-11 | 1978-07-18 | Emery Industries, Inc. | Copolyesters useful in blood separation assemblies |
| US4403090A (en) * | 1982-09-07 | 1983-09-06 | The Goodyear Tire & Rubber Company | Polyisophthalates and copolymers thereof having high barrier properties |
| US4451641A (en) * | 1983-06-13 | 1984-05-29 | Eastman Kodak Company | Radiation-resistant container material of poly(tetramethylene terephthalate) |
| US5102979A (en) * | 1989-06-22 | 1992-04-07 | Mitsubishi Kasei Corporation | Polyester and process for producing the same |
| US5124434A (en) * | 1989-12-04 | 1992-06-23 | Henkel Corporation | Polyesters for use in blood partitioning compositions |
| JP3087770B2 (en) * | 1991-04-02 | 2000-09-11 | 東レ株式会社 | Wrap film for packaging |
| JP3358660B2 (en) * | 1993-07-30 | 2002-12-24 | ヘンケル コーポレーション | Polyester for blood separation |
| JP3386577B2 (en) * | 1994-06-02 | 2003-03-17 | 神東塗料株式会社 | Water-dispersible polyester microgel composition |
| US5731391A (en) * | 1996-09-27 | 1998-03-24 | Henkel Corporation | Fluid composition for physiological separations with enhanced resistance to inward migration of substances requiring accurate dosage monitoring |
| US5986039A (en) * | 1996-10-29 | 1999-11-16 | Henkel Corporation | Branched polyesters prepared from hydroxyfunctional components with functionality in excess of two and their use in physiological separation vehicles |
| JP3749601B2 (en) * | 1997-09-12 | 2006-03-01 | 帝人ファイバー株式会社 | Block copolymer polyester and method for producing the same |
| JPH11114041A (en) * | 1997-10-17 | 1999-04-27 | Nippon Synthetic Chem Ind Co Ltd:The | Aldehyde adsorbent and its application and its use method |
| US6248844B1 (en) * | 1999-06-04 | 2001-06-19 | Henkel Corporation | Method of partitioning blood using polyesters |
-
1999
- 1999-11-03 US US09/433,164 patent/US6072022A/en not_active Expired - Lifetime
-
2000
- 2000-10-03 JP JP2001534489A patent/JP2003513256A/en active Pending
- 2000-10-03 DE DE60024873T patent/DE60024873D1/en not_active Expired - Lifetime
- 2000-10-03 AT AT00967273T patent/ATE312656T1/en not_active IP Right Cessation
- 2000-10-03 AU AU77495/00A patent/AU7749500A/en not_active Abandoned
- 2000-10-03 EP EP00967273A patent/EP1246678B1/en not_active Expired - Lifetime
- 2000-10-03 CA CA2389746A patent/CA2389746C/en not_active Expired - Fee Related
- 2000-10-03 CN CN00815154.7A patent/CN1387456A/en active Pending
- 2000-10-03 WO PCT/US2000/027226 patent/WO2001032290A1/en active IP Right Grant
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