JP2003506475A - 標的脂質粒子 - Google Patents

標的脂質粒子

Info

Publication number
JP2003506475A
JP2003506475A JP2001516501A JP2001516501A JP2003506475A JP 2003506475 A JP2003506475 A JP 2003506475A JP 2001516501 A JP2001516501 A JP 2001516501A JP 2001516501 A JP2001516501 A JP 2001516501A JP 2003506475 A JP2003506475 A JP 2003506475A
Authority
JP
Japan
Prior art keywords
group
lipid
mmol
added
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001516501A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003506475A5 (https=
Inventor
テレンス セワード ベーカー
アンドリュー ニィール チャールス ウェイアー
キャサリン フィオナ キャテラル
マイケル アンソニー ウィリアム イートン
ティモシー ジョン ノーマン
デビット パーカー
Original Assignee
セルテック アール アンド ディ リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by セルテック アール アンド ディ リミテッド filed Critical セルテック アール アンド ディ リミテッド
Publication of JP2003506475A publication Critical patent/JP2003506475A/ja
Publication of JP2003506475A5 publication Critical patent/JP2003506475A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2001516501A 1999-08-16 2000-08-16 標的脂質粒子 Pending JP2003506475A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9919338.5 1999-08-16
GBGB9919338.5A GB9919338D0 (en) 1999-08-16 1999-08-16 Biological products
PCT/GB2000/003170 WO2001012154A2 (en) 1999-08-16 2000-08-16 Targeted lipid particles

Publications (2)

Publication Number Publication Date
JP2003506475A true JP2003506475A (ja) 2003-02-18
JP2003506475A5 JP2003506475A5 (https=) 2007-10-11

Family

ID=10859228

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001516501A Pending JP2003506475A (ja) 1999-08-16 2000-08-16 標的脂質粒子

Country Status (7)

Country Link
US (1) US7718157B1 (https=)
EP (1) EP1204428A2 (https=)
JP (1) JP2003506475A (https=)
AU (1) AU6461400A (https=)
CA (1) CA2379431A1 (https=)
GB (1) GB9919338D0 (https=)
WO (1) WO2001012154A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007500200A (ja) * 2003-05-30 2007-01-11 アステラス製薬株式会社 Ｐ−セレクチン標的リガンドおよびその組成物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004060965A2 (en) 2002-12-31 2004-07-22 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
DE10326303A1 (de) * 2003-06-11 2004-12-30 Celares Gmbh Reagenzien zur Modifikation von Biopharmazeutika, deren Herstellung und Anwendung
US20060246523A1 (en) 2005-04-28 2006-11-02 Christopher Bieniarz Antibody conjugates
DK2963011T3 (en) 2005-11-23 2018-08-06 Ventana Med Syst Inc MOLECULAR CONJUGATE
CN117550985B (zh) * 2023-11-08 2025-02-18 深圳厚存纳米药业有限公司 一种脂质化合物及其用途
WO2026072446A1 (en) * 2024-09-25 2026-04-02 Eli Lilly And Company Conjugates comprising bis-mspt linker

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018185A1 (fr) * 1995-11-14 1997-05-22 Rhone-Poulenc Rorer S.A. Lipopolymamines comme agents de transfection et leurs applications pharmaceutiques
JP2002511446A (ja) * 1998-04-08 2002-04-16 セルテック・セラピューティクス・リミテッド 脂 質

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ336539A (en) 1996-10-15 2000-09-29 Liposome Co Inc Peptide-lipid conjugates, liposomes and liposomal drug delivery
ATE368027T1 (de) 1999-04-26 2007-08-15 Celltech R&D Ltd Bipolare lipide und ihre verwendung zum transport bioaktiver substanzen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018185A1 (fr) * 1995-11-14 1997-05-22 Rhone-Poulenc Rorer S.A. Lipopolymamines comme agents de transfection et leurs applications pharmaceutiques
JP2002511446A (ja) * 1998-04-08 2002-04-16 セルテック・セラピューティクス・リミテッド 脂 質

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6010054767, Ｊｕｒｇｅｎ−Ｈｉｎｒｉｃｈ Ｆｕｈｒｈｏｐ ａｎｄ Ｈｏｌｇｅｒ Ｔａｎｋ, "Ｂｏｌａａｍｐｈｉｐｈｉｌｅｓ ｗｉｔｈ ｍａｎｎｏｓｅ− ａｎｄ ｔｅｔｒａａｌｋｙｌａｍｍｏｎｉｕｍ ｈｅａｄ ｇｒｏｕｐｓ ａｓ ｃｏａｔｉｎｇｓ ｆｏｒ ｎｕｃｌｅｉｃ ａｃｉｄｓ ａｎｄ ｐ", Ｃｈｅｍｉｓｔｒｙ ａｎｄ Ｐｈｙｓｉｃｓ ｏｆ Ｌｉｐｉｄｓ, 1987, Ｖｏｌ． ４３, １９３−２１３ *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007500200A (ja) * 2003-05-30 2007-01-11 アステラス製薬株式会社 Ｐ−セレクチン標的リガンドおよびその組成物
JP4771291B2 (ja) * 2003-05-30 2011-09-14 アステラス製薬株式会社 Ｐ−セレクチン標的リガンドおよびその組成物

Also Published As

Publication number Publication date
GB9919338D0 (en) 1999-10-20
EP1204428A2 (en) 2002-05-15
WO2001012154A3 (en) 2001-10-11
AU6461400A (en) 2001-03-13
CA2379431A1 (en) 2001-02-22
WO2001012154A2 (en) 2001-02-22
US7718157B1 (en) 2010-05-18

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