JP2003504312A - 生物学的に活性な材料 - Google Patents

生物学的に活性な材料

Info

Publication number
JP2003504312A
JP2003504312A JP2001504417A JP2001504417A JP2003504312A JP 2003504312 A JP2003504312 A JP 2003504312A JP 2001504417 A JP2001504417 A JP 2001504417A JP 2001504417 A JP2001504417 A JP 2001504417A JP 2003504312 A JP2003504312 A JP 2003504312A
Authority
JP
Japan
Prior art keywords
dextrin
polymer
drug conjugate
mol
polymeric drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001504417A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003504312A5 (https=
Inventor
ルース ダンカン，
デイル フレツク−ハースト，
リサ ジャーマン，
Original Assignee
エムエル ラボラトリーズ ピーエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9914187.1A external-priority patent/GB9914187D0/en
Priority claimed from GBGB9930252.3A external-priority patent/GB9930252D0/en
Application filed by エムエル ラボラトリーズ ピーエルシー filed Critical エムエル ラボラトリーズ ピーエルシー
Publication of JP2003504312A publication Critical patent/JP2003504312A/ja
Publication of JP2003504312A5 publication Critical patent/JP2003504312A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2001504417A 1999-06-18 2000-06-19 生物学的に活性な材料 Pending JP2003504312A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9914187.1 1999-06-18
GBGB9914187.1A GB9914187D0 (en) 1999-06-18 1999-06-18 Biologically active materials
GB9930252.3 1999-12-22
GBGB9930252.3A GB9930252D0 (en) 1999-12-22 1999-12-22 Biologically active molecules
PCT/GB2000/002216 WO2000078355A2 (en) 1999-06-18 2000-06-19 Biologically active materials

Publications (2)

Publication Number Publication Date
JP2003504312A true JP2003504312A (ja) 2003-02-04
JP2003504312A5 JP2003504312A5 (https=) 2007-07-26

Family

ID=26315678

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001504417A Pending JP2003504312A (ja) 1999-06-18 2000-06-19 生物学的に活性な材料

Country Status (11)

Country Link
US (1) US6818630B1 (https=)
EP (1) EP1198253A2 (https=)
JP (1) JP2003504312A (https=)
AU (1) AU783886B2 (https=)
CA (1) CA2374548A1 (https=)
HK (1) HK1047884A1 (https=)
IL (1) IL146795A0 (https=)
MX (1) MXPA01013276A (https=)
NO (1) NO20016147L (https=)
NZ (1) NZ515999A (https=)
WO (1) WO2000078355A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8106098B2 (en) 1999-08-09 2012-01-31 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
EP1315777B1 (en) 2000-09-06 2007-10-31 AP Pharma, Inc. Degradable polyacetal polymers
DE10112825A1 (de) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10129369C1 (de) 2001-06-21 2003-03-06 Fresenius Kabi De Gmbh Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats
AU2003209227A1 (en) 2002-01-14 2003-07-30 The General Hospital Corporation Biodegradable polyketal polymers and methods for their formation and use
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
US8030459B2 (en) 2002-07-19 2011-10-04 The General Hospital Corporation Oxime conjugates and methods for their formation and use
ATE409048T1 (de) 2002-10-08 2008-10-15 Fresenius Kabi De Gmbh Pharmazeutisch aktive oligosaccharid-conjugate
US7947261B2 (en) * 2003-05-23 2011-05-24 Nektar Therapeutics Conjugates formed from polymer derivatives having particular atom arrangements
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
AU2004270251B2 (en) * 2003-09-05 2011-03-31 The General Hospital Corporation Polyacetal drug conjugates as release system
WO2010068759A1 (en) 2008-12-10 2010-06-17 Mersana Therapeutics, Inc. Pharmaceutical formulations of biodegradable biocompatible camptothecin-polymer conjugates
KR102366322B1 (ko) 2020-07-31 2022-02-22 주식회사 다산네트웍스 전기자전거 주행시스템

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0477931A1 (en) * 1990-09-28 1992-04-01 Mercian Corporation Novel adriamycin derivatives
WO1998056424A1 (en) * 1997-06-12 1998-12-17 Ml Laboratories Plc Biologically active materials

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005199A1 (en) 1993-08-19 1995-02-23 Dextran Products Limited Pharmaceutical preparation and a process for making same
IT1281877B1 (it) 1995-05-10 1998-03-03 Fidia Advanced Biopolymers Srl Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0477931A1 (en) * 1990-09-28 1992-04-01 Mercian Corporation Novel adriamycin derivatives
WO1998056424A1 (en) * 1997-06-12 1998-12-17 Ml Laboratories Plc Biologically active materials

Also Published As

Publication number Publication date
WO2000078355A3 (en) 2002-02-21
HK1047884A1 (zh) 2003-03-14
IL146795A0 (en) 2002-07-25
NZ515999A (en) 2004-03-26
US6818630B1 (en) 2004-11-16
AU783886B2 (en) 2005-12-22
NO20016147D0 (no) 2001-12-17
MXPA01013276A (es) 2002-06-04
CA2374548A1 (en) 2000-12-28
EP1198253A2 (en) 2002-04-24
AU5413000A (en) 2001-01-09
NO20016147L (no) 2002-01-29
WO2000078355A2 (en) 2000-12-28

Similar Documents

Publication Publication Date Title
US7186413B2 (en) Hydrogels and water soluble polymeric carriers for drug delivery
Kostka et al. HPMA-based star polymer biomaterials with tuneable structure and biodegradability tailored for advanced drug delivery to solid tumours
US6822086B1 (en) Drug-carrier complexes and methods of use thereof
US20020155992A1 (en) Poly (dipeptide) as a drug carrier
US20040077595A1 (en) Cyclodextrin-based polymers for therapeutics delivery
JP2014111657A (ja) 放出システムとしてのポリアセタール薬物抱合体
EP2063914B1 (en) Grafted macromolecular conjugates of doxorubicin with anticancer activity and method of their preparation
EP1206252A1 (en) Amplification of folate-mediated targeting to tumor cells using polymers
Howard et al. Polymer micelles with hydrazone-ester dual linkers for tunable release of dexamethasone
JP2003504312A (ja) 生物学的に活性な材料
US6338843B1 (en) Biologically active materials
CN1694728B (zh) 用于传递治疗剂的以环糊精为基础的聚合物
CA2397781A1 (en) Compositions with enhanced oral bioavailability
US20040121954A1 (en) Poly(dipeptide) as a drug carrier
CA2443052A1 (en) Use of cationic dextran derivatives for protecting dose-limiting organs
CN102652836A (zh) 靶向释药的抗癌蛋白质或多肽聚合物前药及其制备方法
AU2002246164A1 (en) Use of cationic dextran derivatives for protecting dose-limiting organs

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070608

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070608

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20101013

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101021

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110705