JP2003502064A5 - - Google Patents
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- Publication number
- JP2003502064A5 JP2003502064A5 JP2001504003A JP2001504003A JP2003502064A5 JP 2003502064 A5 JP2003502064 A5 JP 2003502064A5 JP 2001504003 A JP2001504003 A JP 2001504003A JP 2001504003 A JP2001504003 A JP 2001504003A JP 2003502064 A5 JP2003502064 A5 JP 2003502064A5
- Authority
- JP
- Japan
- Prior art keywords
- smurf
- protein
- nucleic acid
- seq
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004707 nucleic acids Proteins 0.000 description 15
- 150000007523 nucleic acids Chemical class 0.000 description 15
- 102000004169 proteins and genes Human genes 0.000 description 15
- 108090000623 proteins and genes Proteins 0.000 description 15
- 101710043278 SMURF2 Proteins 0.000 description 7
- 101710043289 SMURF1 Proteins 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 125000000539 amino acid group Chemical group 0.000 description 4
- 230000000875 corresponding Effects 0.000 description 4
- 230000035772 mutation Effects 0.000 description 4
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 3
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000003102 growth factor Substances 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 230000004614 tumor growth Effects 0.000 description 3
- 229920001850 Nucleic acid sequence Polymers 0.000 description 2
- 102000007374 Smad Proteins Human genes 0.000 description 2
- 108010007945 Smad Proteins Proteins 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920000272 Oligonucleotide Polymers 0.000 description 1
- 102000004965 antibodies Human genes 0.000 description 1
- 108090001123 antibodies Proteins 0.000 description 1
- 230000000051 modifying Effects 0.000 description 1
- 230000001737 promoting Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000010798 ubiquitination Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13896999P | 1999-06-11 | 1999-06-11 | |
| US60/138,969 | 1999-06-11 | ||
| PCT/US2000/016250 WO2000077168A2 (en) | 1999-06-11 | 2000-06-12 | ANTAGONISTS OF BMP AND TGFβ SIGNALLING PATHWAYS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003502064A JP2003502064A (ja) | 2003-01-21 |
| JP2003502064A5 true JP2003502064A5 (pt) | 2005-12-22 |
Family
ID=22484504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001504003A Pending JP2003502064A (ja) | 1999-06-11 | 2000-06-12 | ＢＭＰおよびＴＧＦβシグナル伝達経路のアンタゴニスト |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1192174A4 (pt) |
| JP (1) | JP2003502064A (pt) |
| CN (1) | CN100379752C (pt) |
| AU (1) | AU782355B2 (pt) |
| CA (1) | CA2376675A1 (pt) |
| IL (1) | IL147005A0 (pt) |
| WO (1) | WO2000077168A2 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7358056B1 (en) | 1999-08-30 | 2008-04-15 | Signal Pharmaceuticals | Methods for modulating signal transduction mediated by TGF-β and related proteins |
| WO2003030924A1 (en) * | 2001-10-09 | 2003-04-17 | Osteoscreen, Inc. | Identification of specific modulators of bone formation |
| CA2531226A1 (en) * | 2003-07-01 | 2005-01-13 | Vib Vzw | Ubiquitinated tnf receptor 2 and its uses |
| US7901874B2 (en) * | 2003-09-11 | 2011-03-08 | Hubit Genomix, Inc. | Methods for identifying agents for preventing or treating proliferative diseases, and for inhibiting extracellular matrix or α1 type IV collagen |
| GB0526664D0 (en) * | 2005-11-30 | 2006-02-08 | Plasticell Ltd | Method |
| JP2009529699A (ja) | 2006-03-01 | 2009-08-20 | ソフトマックス，インコーポレイテッド | 分離信号を生成するシステムおよび方法 |
| WO2008101951A1 (en) | 2007-02-21 | 2008-08-28 | Vib Vzw | Combination therapy using tnf and alfa-galactosyl ceramide |
| CA2688299A1 (en) * | 2007-05-29 | 2008-12-18 | President And Fellows Of Harvard College | Molecules involved in regulation of osteoblast activity and osteoclast activity, and methods of use thereof |
| WO2011088163A1 (en) | 2010-01-14 | 2011-07-21 | President And Fellows Of Harvard College | Methods for modulating skeletal remodeling and patterning by modulating shn2 activity, shn3 activity, or shn2 and shn3 activity in combination |
| TW201946921A (zh) * | 2014-05-14 | 2019-12-16 | 瑞士商諾華公司 | 甲醯胺衍生物 |
| TW201623288A (zh) * | 2014-05-14 | 2016-07-01 | 諾華公司 | 甲醯胺衍生物 |
| KR102360028B1 (ko) * | 2014-12-26 | 2022-02-08 | 삼성전자주식회사 | Smurf2의 저해제를 포함하는 세포 또는 개체의 노화를 감소시키기 위한 조성물 및 그의 용도 |
| CN110196326A (zh) * | 2019-06-05 | 2019-09-03 | 武汉合研生物医药科技有限公司 | 一种TGFβR1（T204D）酶活性的快速检测方法及其应用 |
| CN110592032B (zh) * | 2019-10-14 | 2021-04-13 | 北京理工大学 | 泛素连接酶Smurf1突变体、编码基因及用途 |
| EP4242318A4 (en) | 2021-01-21 | 2024-02-14 | Cellid Co., Ltd | NEW ADENOVIRAL VECTOR NOT INCLUDING REPLICATION COMPETENT ADENOVIRUS AND ASSOCIATED USE |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001619A (en) * | 1995-10-04 | 1999-12-14 | Cold Spring Harbor Laboratory | Ubiquitin ligases, and uses related thereto |
| AU741242B2 (en) * | 1997-05-20 | 2001-11-29 | Ludwig Institute For Cancer Research | Smad2 phosphorylation and interaction with Smad4 |
| US5976849A (en) * | 1998-02-05 | 1999-11-02 | Zeneca Limited | Human E3 ubiquitin protein ligase |
-
2000
- 2000-06-12 EP EP00941398A patent/EP1192174A4/en not_active Withdrawn
- 2000-06-12 IL IL14700500A patent/IL147005A0/xx unknown
- 2000-06-12 AU AU56107/00A patent/AU782355B2/en not_active Ceased
- 2000-06-12 WO PCT/US2000/016250 patent/WO2000077168A2/en active IP Right Grant
- 2000-06-12 CN CNB008113548A patent/CN100379752C/zh not_active Expired - Fee Related
- 2000-06-12 CA CA002376675A patent/CA2376675A1/en not_active Abandoned
- 2000-06-12 JP JP2001504003A patent/JP2003502064A/ja active Pending
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