JP2003321424A5

JP2003321424A5 -

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Publication number: JP2003321424A5
Authority: JP; Japan
Prior art keywords: phenyl; biphenyl; carbonyl; trifluoromethyl; amino
Prior art date: 2003-02-28
Legal status : Granted

Application number

JP2003053869A

Other languages

English (en)

Japanese (ja)

Other versions

JP3662566B2 (ja

JP2003321424A (ja

Filing date

2003-02-28

Publication date

2005-06-23

2003-02-28 Application filed filed Critical

2003-02-28 Priority to JP2003053869A priority Critical patent/JP3662566B2/ja

2003-02-28 Priority claimed from JP2003053869A external-priority patent/JP3662566B2/ja

2003-11-11 Publication of JP2003321424A publication Critical patent/JP2003321424A/ja

2005-06-22 Application granted granted Critical

2005-06-22 Publication of JP3662566B2 publication Critical patent/JP3662566B2/ja

2005-06-23 Publication of JP2003321424A5 publication Critical patent/JP2003321424A5/ja

2023-02-28 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

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-1 ester compound Chemical class 0.000 claims 121
150000003839 salts Chemical class 0.000 claims 46
229940002612 prodrug Drugs 0.000 claims 45
239000000651 prodrug Substances 0.000 claims 45
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 43
VGUWZCUCNQXGBU-UHFFFAOYSA-N 3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1h-indole Chemical compound C1CN(C)CCN1CC1=CNC2=CC=C([N+]([O-])=O)C=C12 VGUWZCUCNQXGBU-UHFFFAOYSA-N 0.000 claims 32
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 32
239000003795 chemical substances by application Substances 0.000 claims 31
239000003814 drug Substances 0.000 claims 31
230000000069 prophylactic effect Effects 0.000 claims 30
230000001225 therapeutic effect Effects 0.000 claims 30
125000005843 halogen group Chemical group 0.000 claims 24
229940079593 drug Drugs 0.000 claims 21
102100031545 Microsomal triglyceride transfer protein large subunit Human genes 0.000 claims 17
108010038232 microsomal triglyceride transfer protein Proteins 0.000 claims 17
125000005915 C6-C14 aryl group Chemical group 0.000 claims 14
125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 11
YCTONGBVYOQJMT-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(pyrrolidine-1-carbonyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)N2CCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 YCTONGBVYOQJMT-UHFFFAOYSA-N 0.000 claims 10
229910052757 nitrogen Inorganic materials 0.000 claims 10
125000004433 nitrogen atom Chemical group N* 0.000 claims 10
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 9
125000000217 alkyl group Chemical group 0.000 claims 8
125000003710 aryl alkyl group Chemical group 0.000 claims 8
125000003118 aryl group Chemical group 0.000 claims 8
206010012601 diabetes mellitus Diseases 0.000 claims 8
ZGJRLDZYCWSCCV-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[2-(trifluoromethyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C(=C1)C(F)(F)F)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZGJRLDZYCWSCCV-UHFFFAOYSA-N 0.000 claims 8
239000003112 inhibitor Substances 0.000 claims 8
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 8
229940124597 therapeutic agent Drugs 0.000 claims 8
208000031226 Hyperlipidaemia Diseases 0.000 claims 7
239000004480 active ingredient Substances 0.000 claims 7
125000000623 heterocyclic group Chemical group 0.000 claims 7
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 6
208000008589 Obesity Diseases 0.000 claims 6
QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
125000002252 acyl group Chemical group 0.000 claims 6
125000004453 alkoxycarbonyl group Chemical group 0.000 claims 6
239000002220 antihypertensive agent Substances 0.000 claims 6
210000004185 liver Anatomy 0.000 claims 6
235000020824 obesity Nutrition 0.000 claims 6
AMMQOFIWXLHNJW-UHFFFAOYSA-N 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioic acid Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC(C(O)=O)(C(O)=O)C1=CC=CC=C1 AMMQOFIWXLHNJW-UHFFFAOYSA-N 0.000 claims 5
125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 5
125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 5
125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 5
125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 5
125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 5
PTMSZUJDCWDNIM-UHFFFAOYSA-N 5-[2-(3-ethoxy-2-ethoxycarbonyl-3-oxo-2-phenylpropoxy)-2-oxoethyl]-2-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoic acid Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(O)=O)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 PTMSZUJDCWDNIM-UHFFFAOYSA-N 0.000 claims 5
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 5
YDYOHTBZCQGLMH-UHFFFAOYSA-N [2-chloro-4-[2-[3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropoxy]-2-oxoethyl]phenyl] 2-[4-(trifluoromethyl)phenyl]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1Cl)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 YDYOHTBZCQGLMH-UHFFFAOYSA-N 0.000 claims 5
CFBFLFVYKYEEJV-UHFFFAOYSA-N [3-(2-methoxyethylamino)-2-(2-methoxyethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCOC)(C(=O)NCCOC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 CFBFLFVYKYEEJV-UHFFFAOYSA-N 0.000 claims 5
DFGHXIXUBYPJQB-UHFFFAOYSA-N [3-(2-methylpropylamino)-2-(2-methylpropylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(C)C)(C(=O)NCC(C)C)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DFGHXIXUBYPJQB-UHFFFAOYSA-N 0.000 claims 5
HIHYOELGVOQNGO-UHFFFAOYSA-N [3-(3-methylbutylamino)-2-(3-methylbutylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCC(C)C)(C(=O)NCCC(C)C)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 HIHYOELGVOQNGO-UHFFFAOYSA-N 0.000 claims 5
XCSGKZORHSMPQF-UHFFFAOYSA-N [3-(butylamino)-2-(butylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCCC)(C(=O)NCCCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XCSGKZORHSMPQF-UHFFFAOYSA-N 0.000 claims 5
MAGIMDGNASRRRZ-UHFFFAOYSA-N [3-(cyclohexylamino)-2-(cyclohexylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC(C=C1)=CC=C1CC(=O)OCC(C=1C=CC=CC=1)(C(=O)NC1CCCCC1)C(=O)NC1CCCCC1 MAGIMDGNASRRRZ-UHFFFAOYSA-N 0.000 claims 5
WAIYBHJEIRHQGY-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(2-methylpropyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1CC(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WAIYBHJEIRHQGY-UHFFFAOYSA-N 0.000 claims 5
JQNSLKHURUPEQI-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(diethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)N(CC)CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JQNSLKHURUPEQI-UHFFFAOYSA-N 0.000 claims 5
WKRMIJRNLKAIQU-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WKRMIJRNLKAIQU-UHFFFAOYSA-N 0.000 claims 5
FWKFITSVDODGAF-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(piperidine-1-carbonyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)N2CCCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FWKFITSVDODGAF-UHFFFAOYSA-N 0.000 claims 5
NHFQUJXTBLFPRU-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-[di(propan-2-yl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)N(C(C)C)C(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NHFQUJXTBLFPRU-UHFFFAOYSA-N 0.000 claims 5
ZBNUMMNPAKPRKH-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-[ethyl(methyl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)N(C)CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZBNUMMNPAKPRKH-UHFFFAOYSA-N 0.000 claims 5
OWQAZUOJCGCXDC-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-[methyl(propan-2-yl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)N(C)C(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 OWQAZUOJCGCXDC-UHFFFAOYSA-N 0.000 claims 5
AYWLLVATNLDIBK-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-[methyl(propyl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)CCC)=CC=1CC(=O)OCC(C(=O)NCC)(C(=O)NCC)C1=CC=CC=C1 AYWLLVATNLDIBK-UHFFFAOYSA-N 0.000 claims 5
VHCRJSOJSAMPCR-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-ethoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1OCC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VHCRJSOJSAMPCR-UHFFFAOYSA-N 0.000 claims 5
VDHCJCXXYLHWAB-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-ethyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VDHCJCXXYLHWAB-UHFFFAOYSA-N 0.000 claims 5
NZNUZVSFKVHRSA-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-hydroxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1O)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NZNUZVSFKVHRSA-UHFFFAOYSA-N 0.000 claims 5
FCRDUDHCGYHDDW-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FCRDUDHCGYHDDW-UHFFFAOYSA-N 0.000 claims 5
UCMNZVKXQRAGGY-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UCMNZVKXQRAGGY-UHFFFAOYSA-N 0.000 claims 5
IRROEFVBBOXXFG-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-phenylmethoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1OCC=2C=CC=CC=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 IRROEFVBBOXXFG-UHFFFAOYSA-N 0.000 claims 5
DZVCVGDQRQMIGL-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-piperidin-1-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1N2CCCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DZVCVGDQRQMIGL-UHFFFAOYSA-N 0.000 claims 5
SOMZASTXYLSNTM-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-propan-2-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 SOMZASTXYLSNTM-UHFFFAOYSA-N 0.000 claims 5
KCMCSGBVERRGNI-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-propan-2-yloxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1OC(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 KCMCSGBVERRGNI-UHFFFAOYSA-N 0.000 claims 5
GOMHCLVRTCQSTR-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-propoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(OCCC)=CC=1CC(=O)OCC(C(=O)NCC)(C(=O)NCC)C1=CC=CC=C1 GOMHCLVRTCQSTR-UHFFFAOYSA-N 0.000 claims 5
QEZKAQXBQPBBBT-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-pyrrolidin-1-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1N2CCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QEZKAQXBQPBBBT-UHFFFAOYSA-N 0.000 claims 5
ZYHNGVIIMSMQEY-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[(2-phenylbenzoyl)amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=CC=C1 ZYHNGVIIMSMQEY-UHFFFAOYSA-N 0.000 claims 5
HOSCJSLPFBRCOK-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-(3,4-dichlorophenyl)benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(Cl)C(Cl)=C1 HOSCJSLPFBRCOK-UHFFFAOYSA-N 0.000 claims 5
UKWCRRMWWDPWIC-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-(4-chlorophenyl)benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(Cl)C=C1 UKWCRRMWWDPWIC-UHFFFAOYSA-N 0.000 claims 5
YXSJUDDDSJWUQS-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 YXSJUDDDSJWUQS-UHFFFAOYSA-N 0.000 claims 5
WVWLTHWFFAXMBN-UHFFFAOYSA-N [3-(methylamino)-2-(methylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NC)(C(=O)NC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WVWLTHWFFAXMBN-UHFFFAOYSA-N 0.000 claims 5
YGRZKEKEFVYSER-UHFFFAOYSA-N [3-anilino-3-oxo-2-phenyl-2-(phenylcarbamoyl)propyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC(C=C1)=CC=C1CC(=O)OCC(C=1C=CC=CC=1)(C(=O)NC=1C=CC=CC=1)C(=O)NC1=CC=CC=C1 YGRZKEKEFVYSER-UHFFFAOYSA-N 0.000 claims 5
GYBGTVFSTMDCJK-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)-2-(2,2,2-trifluoroethylcarbamoyl)propyl] 2-[4-[(2-phenylbenzoyl)amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)(C(=O)NCC(F)(F)F)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=CC=C1 GYBGTVFSTMDCJK-UHFFFAOYSA-N 0.000 claims 5
ZWQZMSAKNTZADX-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)-2-(2,2,2-trifluoroethylcarbamoyl)propyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)(C(=O)NCC(F)(F)F)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZWQZMSAKNTZADX-UHFFFAOYSA-N 0.000 claims 5
XGRAWMZOYKHADZ-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(propan-2-ylamino)-2-(propan-2-ylcarbamoyl)propyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NC(C)C)(C(=O)NC(C)C)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XGRAWMZOYKHADZ-UHFFFAOYSA-N 0.000 claims 5
DEEWGADMSNAMJZ-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(propylamino)-2-(propylcarbamoyl)propyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCC)(C(=O)NCCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DEEWGADMSNAMJZ-UHFFFAOYSA-N 0.000 claims 5
HBQNCNWIWAUDEO-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(propylamino)-2-(propylcarbamoyl)propyl] 2-[3-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCC)(C(=O)NCCC)COC(=O)CC(C=C1C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 HBQNCNWIWAUDEO-UHFFFAOYSA-N 0.000 claims 5
LHFAGDIJHIHIFC-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 LHFAGDIJHIHIFC-UHFFFAOYSA-N 0.000 claims 5
HIBYADHVPNNANO-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-[ethyl(methyl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1C(=O)N(C)CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 HIBYADHVPNNANO-UHFFFAOYSA-N 0.000 claims 5
QRDINOXMOOVSQB-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-[methyl(propyl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)CCC)=CC=1CC(=O)OCCC(C(=O)NCC)(C(=O)NCC)C1=CC=CC=C1 QRDINOXMOOVSQB-UHFFFAOYSA-N 0.000 claims 5
FURGMBSIHLXZPV-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-ethoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1OCC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FURGMBSIHLXZPV-UHFFFAOYSA-N 0.000 claims 5
VKQWBAHJJDDKIS-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-ethyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VKQWBAHJJDDKIS-UHFFFAOYSA-N 0.000 claims 5
NJEHRVLBDMDIMY-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-propan-2-yloxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1OC(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NJEHRVLBDMDIMY-UHFFFAOYSA-N 0.000 claims 5
AASLRCUIMHVVAU-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 AASLRCUIMHVVAU-UHFFFAOYSA-N 0.000 claims 5
QKAKMQICFFRSCS-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 3-chloro-4-[2-[4-(trifluoromethyl)phenyl]benzoyl]oxybenzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)C(C=C1Cl)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QKAKMQICFFRSCS-UHFFFAOYSA-N 0.000 claims 5
NIIOQUAZHXNTQW-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NIIOQUAZHXNTQW-UHFFFAOYSA-N 0.000 claims 5
PFXWMKPZCNOEGO-UHFFFAOYSA-N [4-[2-oxo-2-[3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)-2-(2,2,2-trifluoroethylcarbamoyl)propoxy]ethyl]phenyl] 2-[4-(trifluoromethyl)phenyl]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)(C(=O)NCC(F)(F)F)COC(=O)CC(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 PFXWMKPZCNOEGO-UHFFFAOYSA-N 0.000 claims 5
DMFXDHPZDPSKKE-UHFFFAOYSA-N [4-[2-oxo-2-[3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)-2-(2,2,2-trifluoroethylcarbamoyl)propoxy]ethyl]phenyl] 2-phenylbenzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)(C(=O)NCC(F)(F)F)COC(=O)CC(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=CC=C1 DMFXDHPZDPSKKE-UHFFFAOYSA-N 0.000 claims 5
BGFXOQFHFAXQIL-UHFFFAOYSA-N [4-[4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutoxy]carbonylphenyl] 2-[4-(trifluoromethyl)phenyl]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)C(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BGFXOQFHFAXQIL-UHFFFAOYSA-N 0.000 claims 5
SEQUXWDZPPNBFG-UHFFFAOYSA-N [4-oxo-3-phenyl-4-(propylamino)-3-(propylcarbamoyl)butyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCC)(C(=O)NCCC)CCOC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 SEQUXWDZPPNBFG-UHFFFAOYSA-N 0.000 claims 5
KMOJSUYDGMMPKZ-UHFFFAOYSA-N [5-(ethylamino)-4-(ethylcarbamoyl)-5-oxo-4-phenylpentyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCCOC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 KMOJSUYDGMMPKZ-UHFFFAOYSA-N 0.000 claims 5
125000002102 aryl alkyloxo group Chemical group 0.000 claims 5
LUYWZYCPFLPYCW-UHFFFAOYSA-N benzyl 5-[2-[3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropoxy]-2-oxoethyl]-2-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)OCC=2C=CC=CC=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 LUYWZYCPFLPYCW-UHFFFAOYSA-N 0.000 claims 5
WCHYAQSECVPREY-UHFFFAOYSA-N bis(2-methylpropyl) 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC(C)C)(C(=O)OCC(C)C)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WCHYAQSECVPREY-UHFFFAOYSA-N 0.000 claims 5
125000000753 cycloalkyl group Chemical group 0.000 claims 5
NMGIQDDNASBFBY-UHFFFAOYSA-N dicyclohexyl 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC(C=C1)=CC=C1CC(=O)OCC(C=1C=CC=CC=1)(C(=O)OC1CCCCC1)C(=O)OC1CCCCC1 NMGIQDDNASBFBY-UHFFFAOYSA-N 0.000 claims 5
WDDZGKRLQQENAE-UHFFFAOYSA-N diethyl 2-[2-[2-[3-(dimethylcarbamoyl)-4-[[4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1C1=CC=C(C(F)(F)F)C=C1 WDDZGKRLQQENAE-UHFFFAOYSA-N 0.000 claims 5
ZOLGRHUWNCZOFY-UHFFFAOYSA-N diethyl 2-[2-[2-[3-(dimethylcarbamoyl)-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C)C=C1C1=CC=C(C(F)(F)F)C=C1 ZOLGRHUWNCZOFY-UHFFFAOYSA-N 0.000 claims 5
KZKOOWGZUAINSN-UHFFFAOYSA-N diethyl 2-[2-[2-chloro-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)C(C(=C1)Cl)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 KZKOOWGZUAINSN-UHFFFAOYSA-N 0.000 claims 5
YHQGUNJPAAVYRT-UHFFFAOYSA-N diethyl 2-[3-[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxypropyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCCOC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 YHQGUNJPAAVYRT-UHFFFAOYSA-N 0.000 claims 5
RXQBXNWFJRSNLR-UHFFFAOYSA-N diethyl 2-[3-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]propanoyloxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CCC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 RXQBXNWFJRSNLR-UHFFFAOYSA-N 0.000 claims 5
PQYQHQHKLZPUGP-UHFFFAOYSA-N diethyl 2-[[2-[2-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C(=C1)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 PQYQHQHKLZPUGP-UHFFFAOYSA-N 0.000 claims 5
ZCFVKPQPKGPBJV-UHFFFAOYSA-N diethyl 2-[[2-[3-(2-methylpropanoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)C(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZCFVKPQPKGPBJV-UHFFFAOYSA-N 0.000 claims 5
KGENKWUIWLJMTO-UHFFFAOYSA-N diethyl 2-[[2-[3-(4-methyl-1,3-thiazol-2-yl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C=2SC=C(C)N=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 KGENKWUIWLJMTO-UHFFFAOYSA-N 0.000 claims 5
XIRSBALRSUGZJS-UHFFFAOYSA-N diethyl 2-[[2-[3-(diethylamino)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1N(CC)CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XIRSBALRSUGZJS-UHFFFAOYSA-N 0.000 claims 5
DNIUSHRQIMHNGP-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylamino)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DNIUSHRQIMHNGP-UHFFFAOYSA-N 0.000 claims 5
YADROHWZRUUBQB-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[2-[4-(trifluoromethyl)phenyl]benzoyl]oxyphenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 YADROHWZRUUBQB-UHFFFAOYSA-N 0.000 claims 5
DHGVRVNVNPHFIK-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-(4-ethylphenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(CC)C=C1 DHGVRVNVNPHFIK-UHFFFAOYSA-N 0.000 claims 5
ITUZZAFKZDHVQE-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-(4-fluorophenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(F)C=C1 ITUZZAFKZDHVQE-UHFFFAOYSA-N 0.000 claims 5
ZBSOGIQKERKSCH-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-(4-methylphenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C)C=C1 ZBSOGIQKERKSCH-UHFFFAOYSA-N 0.000 claims 5
CQQKNFFDPBRYCS-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-(4-prop-1-en-2-ylphenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(C)=C)C=C1 CQQKNFFDPBRYCS-UHFFFAOYSA-N 0.000 claims 5
TVZOEIGIFBAXHY-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-(4-propan-2-ylphenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(C)C)C=C1 TVZOEIGIFBAXHY-UHFFFAOYSA-N 0.000 claims 5
YHNSSFYTXVDPMR-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[2-fluoro-4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1F YHNSSFYTXVDPMR-UHFFFAOYSA-N 0.000 claims 5
LHQHRAXQAXGXQN-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C(F)=C1 LHQHRAXQAXGXQN-UHFFFAOYSA-N 0.000 claims 5
OFPAVWJFHPRWJZ-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(1,3-thiazol-2-yl)propanedioate Chemical compound N=1C=CSC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 OFPAVWJFHPRWJZ-UHFFFAOYSA-N 0.000 claims 5
UQNZJMYBNXNYTD-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(2-methylphenyl)propanedioate Chemical compound C=1C=CC=C(C)C=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UQNZJMYBNXNYTD-UHFFFAOYSA-N 0.000 claims 5
RHQFACXKVAZQEQ-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(3-methylphenyl)propanedioate Chemical compound C=1C=CC(C)=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 RHQFACXKVAZQEQ-UHFFFAOYSA-N 0.000 claims 5
PKPOUGBPUSRAEB-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(3-methylthiophen-2-yl)propanedioate Chemical compound S1C=CC(C)=C1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 PKPOUGBPUSRAEB-UHFFFAOYSA-N 0.000 claims 5
UDLMNDUFPKUJSY-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(4-methylphenyl)propanedioate Chemical compound C=1C=C(C)C=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UDLMNDUFPKUJSY-UHFFFAOYSA-N 0.000 claims 5
XPRIDZRFMYZQSM-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(5-methylthiophen-2-yl)propanedioate Chemical compound C=1C=C(C)SC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XPRIDZRFMYZQSM-UHFFFAOYSA-N 0.000 claims 5
XEMLRDPGOJPHDL-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(5-nitropyridin-2-yl)propanedioate Chemical compound C=1C=C([N+]([O-])=O)C=NC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XEMLRDPGOJPHDL-UHFFFAOYSA-N 0.000 claims 5
ARYPVXBIDOGRHU-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylbutanedioate Chemical compound C=1C=CC=CC=1C(CC(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ARYPVXBIDOGRHU-UHFFFAOYSA-N 0.000 claims 5
ZBORAOCCJCJTHA-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-pyridin-2-ylpropanedioate Chemical compound C=1C=CC=NC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZBORAOCCJCJTHA-UHFFFAOYSA-N 0.000 claims 5
DAPBKZSHKPPWKF-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-thiophen-2-ylpropanedioate Chemical compound C=1C=CSC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DAPBKZSHKPPWKF-UHFFFAOYSA-N 0.000 claims 5
NEBLXFSOGXOHGE-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-thiophen-3-ylpropanedioate Chemical compound C1=CSC=C1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NEBLXFSOGXOHGE-UHFFFAOYSA-N 0.000 claims 5
IOUAIYUEZSPYQI-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-ethyl-4-(trifluoromethyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1CC IOUAIYUEZSPYQI-UHFFFAOYSA-N 0.000 claims 5
UQVFFSRYZKEVAA-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[3-fluoro-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC(F)=C1C1=CC=C(C(F)(F)F)C=C1 UQVFFSRYZKEVAA-UHFFFAOYSA-N 0.000 claims 5
NSHDBBXTDASVHG-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[3-methoxy-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC(OC)=C1C1=CC=C(C(F)(F)F)C=C1 NSHDBBXTDASVHG-UHFFFAOYSA-N 0.000 claims 5
NKGWHTODKOYZMP-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1C1=CC=C(C(F)(F)F)C=C1 NKGWHTODKOYZMP-UHFFFAOYSA-N 0.000 claims 5
YMWUDKGZMSDSCV-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[4-ethoxy-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(OCC)C=C1C1=CC=C(C(F)(F)F)C=C1 YMWUDKGZMSDSCV-UHFFFAOYSA-N 0.000 claims 5
OZOLXOKXJZKKAP-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[4-methoxy-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(OC)C=C1C1=CC=C(C(F)(F)F)C=C1 OZOLXOKXJZKKAP-UHFFFAOYSA-N 0.000 claims 5
AQAQSTFAUQIWBD-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C)C=C1C1=CC=C(C(F)(F)F)C=C1 AQAQSTFAUQIWBD-UHFFFAOYSA-N 0.000 claims 5
QKDJFYOBSFGMFD-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[4-propan-2-yloxy-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(OC(C)C)C=C1C1=CC=C(C(F)(F)F)C=C1 QKDJFYOBSFGMFD-UHFFFAOYSA-N 0.000 claims 5
FMXXDZOSHNWORQ-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[5-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC(C)=CC=C1C1=CC=C(C(F)(F)F)C=C1 FMXXDZOSHNWORQ-UHFFFAOYSA-N 0.000 claims 5
VOCOBGKMMMDCLO-UHFFFAOYSA-N diethyl 2-[[2-[3-(methoxycarbonylamino)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1NC(=O)OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VOCOBGKMMMDCLO-UHFFFAOYSA-N 0.000 claims 5
JPLWDRVFJCTLTM-UHFFFAOYSA-N diethyl 2-[[2-[3-[(dimethylamino)methyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1CN(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JPLWDRVFJCTLTM-UHFFFAOYSA-N 0.000 claims 5
XFWHHJAJDSGMDJ-UHFFFAOYSA-N diethyl 2-[[2-[3-[di(propan-2-yl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C(C)C)C(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XFWHHJAJDSGMDJ-UHFFFAOYSA-N 0.000 claims 5
WDYJRWDDNFJIIF-UHFFFAOYSA-N diethyl 2-[[2-[3-[ethyl(methyl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WDYJRWDDNFJIIF-UHFFFAOYSA-N 0.000 claims 5
AONKRNBFMYDDNY-UHFFFAOYSA-N diethyl 2-[[2-[3-[methoxy(methyl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 AONKRNBFMYDDNY-UHFFFAOYSA-N 0.000 claims 5
BFLQTUDYSYNTFK-UHFFFAOYSA-N diethyl 2-[[2-[3-acetamido-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1NC(C)=O)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BFLQTUDYSYNTFK-UHFFFAOYSA-N 0.000 claims 5
QSALIZYUAMVOJD-UHFFFAOYSA-N diethyl 2-[[2-[3-bromo-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1Br)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QSALIZYUAMVOJD-UHFFFAOYSA-N 0.000 claims 5
DITBXJLZCBMEJK-UHFFFAOYSA-N diethyl 2-[[2-[3-bromo-5-(dimethylcarbamoyl)-2-fluoro-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C(=C1Br)F)=CC(C(=O)N(C)C)=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DITBXJLZCBMEJK-UHFFFAOYSA-N 0.000 claims 5
VLJMVLJVRQYUNA-UHFFFAOYSA-N diethyl 2-[[2-[3-bromo-5-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC(Br)=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VLJMVLJVRQYUNA-UHFFFAOYSA-N 0.000 claims 5
BJYOVAQOPCNJJZ-UHFFFAOYSA-N diethyl 2-[[2-[3-chloro-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1Cl)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BJYOVAQOPCNJJZ-UHFFFAOYSA-N 0.000 claims 5
JIGCNLSLFSZUBN-UHFFFAOYSA-N diethyl 2-[[2-[3-chloro-5-(dimethylcarbamoyl)-2-fluoro-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C(=C1Cl)F)=CC(C(=O)N(C)C)=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JIGCNLSLFSZUBN-UHFFFAOYSA-N 0.000 claims 5
JQVSERUQWKUTNM-UHFFFAOYSA-N diethyl 2-[[2-[3-chloro-5-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC(Cl)=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JQVSERUQWKUTNM-UHFFFAOYSA-N 0.000 claims 5
ZPQCSGMTOBGHEX-UHFFFAOYSA-N diethyl 2-[[2-[3-ethoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1OCC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZPQCSGMTOBGHEX-UHFFFAOYSA-N 0.000 claims 5
JNNUTCZXEWHFAE-UHFFFAOYSA-N diethyl 2-[[2-[3-ethoxycarbonyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)OCC)=CC=1CC(=O)OCC(C(=O)OCC)(C(=O)OCC)C1=CC=CC=C1 JNNUTCZXEWHFAE-UHFFFAOYSA-N 0.000 claims 5
JJNIUYYXGTZUAE-UHFFFAOYSA-N diethyl 2-[[2-[3-ethyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JJNIUYYXGTZUAE-UHFFFAOYSA-N 0.000 claims 5
QYBKHGFPCWVXGA-UHFFFAOYSA-N diethyl 2-[[2-[3-formyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C=O)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QYBKHGFPCWVXGA-UHFFFAOYSA-N 0.000 claims 5
UQMLHUONUHEPTG-UHFFFAOYSA-N diethyl 2-[[2-[3-hydroxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1O)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UQMLHUONUHEPTG-UHFFFAOYSA-N 0.000 claims 5
WCSFLQQQRIFLOM-UHFFFAOYSA-N diethyl 2-[[2-[3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WCSFLQQQRIFLOM-UHFFFAOYSA-N 0.000 claims 5
JTSALHZINIJVKA-UHFFFAOYSA-N diethyl 2-[[2-[3-methoxycarbonyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JTSALHZINIJVKA-UHFFFAOYSA-N 0.000 claims 5
HNUHDUOAQMEOMU-UHFFFAOYSA-N diethyl 2-[[2-[3-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 HNUHDUOAQMEOMU-UHFFFAOYSA-N 0.000 claims 5
PWHCSPVQLQMAKI-UHFFFAOYSA-N diethyl 2-[[2-[3-morpholin-4-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1N2CCOCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 PWHCSPVQLQMAKI-UHFFFAOYSA-N 0.000 claims 5
QPWRSIOICZIZFE-UHFFFAOYSA-N diethyl 2-[[2-[4-(dimethylcarbamoyl)-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]pyridin-2-yl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(N=C1)=CC(C(=O)N(C)C)=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QPWRSIOICZIZFE-UHFFFAOYSA-N 0.000 claims 5
JXDJXXNXUMYJAM-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2,4-bis(trifluoromethyl)benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1C(F)(F)F JXDJXXNXUMYJAM-UHFFFAOYSA-N 0.000 claims 5
XFTJHJQRJIJEJH-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-acetylphenyl)benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(C)=O)C=C1 XFTJHJQRJIJEJH-UHFFFAOYSA-N 0.000 claims 5
JRWZHGOZIIGYDU-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-bromophenyl)benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(Br)C=C1 JRWZHGOZIIGYDU-UHFFFAOYSA-N 0.000 claims 5
JNZGMEMZRZAERN-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-chlorophenyl)benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(Cl)C=C1 JNZGMEMZRZAERN-UHFFFAOYSA-N 0.000 claims 5
KGCDKDLWNXXRFV-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-cyanophenyl)benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C#N)C=C1 KGCDKDLWNXXRFV-UHFFFAOYSA-N 0.000 claims 5
LZCHVDSKNDHAOJ-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-methoxyphenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(OC)C=C1 LZCHVDSKNDHAOJ-UHFFFAOYSA-N 0.000 claims 5
BGLKZLSYHVCCKG-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-methylphenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C)C=C1 BGLKZLSYHVCCKG-UHFFFAOYSA-N 0.000 claims 5
BHNMYNFFQOTSHQ-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-[3-chloro-4-(trifluoromethyl)phenyl]benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C(Cl)=C1 BHNMYNFFQOTSHQ-UHFFFAOYSA-N 0.000 claims 5
ULLUGLVTASFFSI-UHFFFAOYSA-N diethyl 2-[[2-[4-[[3-chloro-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC(Cl)=C1C1=CC=C(C(F)(F)F)C=C1 ULLUGLVTASFFSI-UHFFFAOYSA-N 0.000 claims 5
KNZWSIOXCHPTIY-UHFFFAOYSA-N diethyl 2-[[2-[4-[[4-chloro-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(Cl)C=C1C1=CC=C(C(F)(F)F)C=C1 KNZWSIOXCHPTIY-UHFFFAOYSA-N 0.000 claims 5
RHQODGJKTHSOSK-UHFFFAOYSA-N diethyl 2-[[2-[4-[cyclohexyl-[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1N(C(=O)C=1C(=CC=CC=1)C=1C=CC(=CC=1)C(F)(F)F)C1CCCCC1 RHQODGJKTHSOSK-UHFFFAOYSA-N 0.000 claims 5
BYZSMHCEVWSYNZ-UHFFFAOYSA-N diethyl 2-[[2-[4-[ethyl-[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1N(CC)C(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BYZSMHCEVWSYNZ-UHFFFAOYSA-N 0.000 claims 5
UEOVIJRSLCPDLW-UHFFFAOYSA-N diethyl 2-[[2-[4-[methyl-[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1N(C)C(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UEOVIJRSLCPDLW-UHFFFAOYSA-N 0.000 claims 5
XKIOHZHJOXNEDD-UHFFFAOYSA-N diethyl 2-[[2-[5-(dimethylcarbamoyl)-2-fluoro-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C(=C1)F)=CC(C(=O)N(C)C)=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XKIOHZHJOXNEDD-UHFFFAOYSA-N 0.000 claims 5
IHJDXXYPXNHHIX-UHFFFAOYSA-N diethyl 2-benzyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1CC(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 IHJDXXYPXNHHIX-UHFFFAOYSA-N 0.000 claims 5
AUZVZFRTWPBNSU-UHFFFAOYSA-N diethyl 2-cyclohexyl-2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C1CCCCC1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 AUZVZFRTWPBNSU-UHFFFAOYSA-N 0.000 claims 5
CAUSRFIXGJUMIM-UHFFFAOYSA-N diethyl 2-cyclohexyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C1CCCCC1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 CAUSRFIXGJUMIM-UHFFFAOYSA-N 0.000 claims 5
WNAGUAJYPFLTNP-UHFFFAOYSA-N diethyl 2-cyclopentyl-2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C1CCCC1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WNAGUAJYPFLTNP-UHFFFAOYSA-N 0.000 claims 5
XSURSZJBHYZJJO-UHFFFAOYSA-N diethyl 2-cyclopentyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C1CCCC1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XSURSZJBHYZJJO-UHFFFAOYSA-N 0.000 claims 5
ZEHFIMSMADZESI-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-(pyrrolidine-1-carbonyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N2CCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZEHFIMSMADZESI-UHFFFAOYSA-N 0.000 claims 5
BZBRIHBDVDUCFO-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-phenyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C=2C=CC=CC=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BZBRIHBDVDUCFO-UHFFFAOYSA-N 0.000 claims 5
LGYSSKPTXWNPKH-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-phenylmethoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1OCC=2C=CC=CC=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 LGYSSKPTXWNPKH-UHFFFAOYSA-N 0.000 claims 5
QJZMAIDVXSIIFK-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-phenylmethoxycarbonyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)OCC=2C=CC=CC=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QJZMAIDVXSIIFK-UHFFFAOYSA-N 0.000 claims 5
UFYDSTAIJUDNHE-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-piperidin-1-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1N2CCCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UFYDSTAIJUDNHE-UHFFFAOYSA-N 0.000 claims 5
FEWGQHYTEGBJFY-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-propan-2-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FEWGQHYTEGBJFY-UHFFFAOYSA-N 0.000 claims 5
FPDIEXMCHOROPA-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-propan-2-yloxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1OC(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FPDIEXMCHOROPA-UHFFFAOYSA-N 0.000 claims 5
WEHSHKXBBBYNFJ-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-propan-2-yloxycarbonyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)OC(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WEHSHKXBBBYNFJ-UHFFFAOYSA-N 0.000 claims 5
FLFIHJWMQVMSMT-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-pyrrolidin-1-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1N2CCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FLFIHJWMQVMSMT-UHFFFAOYSA-N 0.000 claims 5
YUNQRDJOOWZLOS-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[2-[4-(trifluoromethyl)phenyl]benzoyl]oxyphenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 YUNQRDJOOWZLOS-UHFFFAOYSA-N 0.000 claims 5
VHDOPMHJSBYYHC-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[[2-[3-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=CC(C(F)(F)F)=C1 VHDOPMHJSBYYHC-UHFFFAOYSA-N 0.000 claims 5
MPAQJJHEYFQVKF-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 MPAQJJHEYFQVKF-UHFFFAOYSA-N 0.000 claims 5
FJYWNJJUAJOEJL-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[propan-2-yl-[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1N(C(C)C)C(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FJYWNJJUAJOEJL-UHFFFAOYSA-N 0.000 claims 5
VILOIKMDJRUCLA-UHFFFAOYSA-N diethyl 2-pyridin-2-yl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=NC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VILOIKMDJRUCLA-UHFFFAOYSA-N 0.000 claims 5
UMLUDJUUFTZTNT-UHFFFAOYSA-N diethyl 2-pyridin-3-yl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CN=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UMLUDJUUFTZTNT-UHFFFAOYSA-N 0.000 claims 5
XCLRUDOZRXMGPG-UHFFFAOYSA-N dimethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OC)(C(=O)OC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XCLRUDOZRXMGPG-UHFFFAOYSA-N 0.000 claims 5
MKCRYYQSLDSGEA-UHFFFAOYSA-N dimethyl 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OC)(C(=O)OC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 MKCRYYQSLDSGEA-UHFFFAOYSA-N 0.000 claims 5
GAESNEVCLFYTIY-UHFFFAOYSA-N dipropan-2-yl 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OC(C)C)(C(=O)OC(C)C)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 GAESNEVCLFYTIY-UHFFFAOYSA-N 0.000 claims 5
CFVBWOFPRDHFBM-UHFFFAOYSA-N dipropyl 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCCC)(C(=O)OCCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 CFVBWOFPRDHFBM-UHFFFAOYSA-N 0.000 claims 5
ZONYXWQDUYMKFB-UHFFFAOYSA-N flavanone Chemical compound O1C2=CC=CC=C2C(=O)CC1C1=CC=CC=C1 ZONYXWQDUYMKFB-UHFFFAOYSA-N 0.000 claims 5
OZJKOVUQNPNXAQ-UHFFFAOYSA-N methyl 5-[2-[3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropoxy]-2-oxoethyl]-2-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 OZJKOVUQNPNXAQ-UHFFFAOYSA-N 0.000 claims 5
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
238000002360 preparation method Methods 0.000 claims 5
230000002265 prevention Effects 0.000 claims 5
LTMRRSWNXVJMBA-UHFFFAOYSA-L 2,2-diethylpropanedioate Chemical compound CCC(CC)(C([O-])=O)C([O-])=O LTMRRSWNXVJMBA-UHFFFAOYSA-L 0.000 claims 4
MEAPRSDUXBHXGD-UHFFFAOYSA-N 3-chloro-n-(4-propan-2-ylphenyl)propanamide Chemical compound CC(C)C1=CC=C(NC(=O)CCCl)C=C1 MEAPRSDUXBHXGD-UHFFFAOYSA-N 0.000 claims 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 4
206010020772 Hypertension Diseases 0.000 claims 4
102000004877 Insulin Human genes 0.000 claims 4
108090001061 Insulin Proteins 0.000 claims 4
HKQLLOCMUWZCAB-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(benzylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)NCC=2C=CC=CC=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 HKQLLOCMUWZCAB-UHFFFAOYSA-N 0.000 claims 4
LPHFJAHVHXGCJC-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(dimethylamino)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 LPHFJAHVHXGCJC-UHFFFAOYSA-N 0.000 claims 4
DXXPLWNAZWAMJS-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(methylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)NC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DXXPLWNAZWAMJS-UHFFFAOYSA-N 0.000 claims 4
DONVKTBFBUILDH-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(propylamino)-2-(propylcarbamoyl)propyl] 2-[3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCC)(C(=O)NCCC)COC(=O)CC(C=C1OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DONVKTBFBUILDH-UHFFFAOYSA-N 0.000 claims 4
HMDOGEKFEHPEOR-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[2-ethoxy-3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=1OCC)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 HMDOGEKFEHPEOR-UHFFFAOYSA-N 0.000 claims 4
TZJVBXLUNRXPSD-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[2-methoxy-3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=1OC)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 TZJVBXLUNRXPSD-UHFFFAOYSA-N 0.000 claims 4
JEOZGGCGGYSTMK-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[2-methyl-3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=1C)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JEOZGGCGGYSTMK-UHFFFAOYSA-N 0.000 claims 4
MPGUAMBHIDDTBK-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=1)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 MPGUAMBHIDDTBK-UHFFFAOYSA-N 0.000 claims 4
XWFCGZFKTKCKQH-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XWFCGZFKTKCKQH-UHFFFAOYSA-N 0.000 claims 4
WEUZMSLVMQPRIK-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 3,5-dichloro-4-[2-[4-(trifluoromethyl)phenyl]benzoyl]oxybenzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)C(C=C1Cl)=CC(Cl)=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WEUZMSLVMQPRIK-UHFFFAOYSA-N 0.000 claims 4
NIIUYOQBXOYVNI-UHFFFAOYSA-N [4-[2-[3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropoxy]-2-oxoethyl]phenyl] 2-[4-(trifluoromethyl)phenyl]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NIIUYOQBXOYVNI-UHFFFAOYSA-N 0.000 claims 4
ADAGVMBJRMVJDJ-UHFFFAOYSA-N [4-oxo-3-phenyl-4-(propylamino)-3-(propylcarbamoyl)butyl] 2-[2-methyl-3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCC)(C(=O)NCCC)CCOC(=O)CC(C=1C)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ADAGVMBJRMVJDJ-UHFFFAOYSA-N 0.000 claims 4
OJYSEEYBKKNIQZ-UHFFFAOYSA-N [4-oxo-3-phenyl-4-(propylamino)-3-(propylcarbamoyl)butyl] 2-[3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCC)(C(=O)NCCC)CCOC(=O)CC(C=1)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 OJYSEEYBKKNIQZ-UHFFFAOYSA-N 0.000 claims 4
MUYGQRZCXIRFRU-UHFFFAOYSA-N [5-(ethylamino)-4-(ethylcarbamoyl)-5-oxo-4-phenylpentyl] 2-[2-methyl-3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCCOC(=O)CC(C=1C)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 MUYGQRZCXIRFRU-UHFFFAOYSA-N 0.000 claims 4
229940127088 antihypertensive drug Drugs 0.000 claims 4
IUGQFMIATSVYLK-UHFFFAOYSA-N benzyl 2-(4-hydroxyphenyl)acetate Chemical compound C1=CC(O)=CC=C1CC(=O)OCC1=CC=CC=C1 IUGQFMIATSVYLK-UHFFFAOYSA-N 0.000 claims 4
239000002876 beta blocker Substances 0.000 claims 4
229940097320 beta blocking agent Drugs 0.000 claims 4
229960003612 bunazosin hydrochloride Drugs 0.000 claims 4
229960000830 captopril Drugs 0.000 claims 4
FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 claims 4
FYBXRCFPOTXTJF-UHFFFAOYSA-N carteolol hydrochloride Chemical compound [Cl-].N1C(=O)CCC2=C1C=CC=C2OCC(O)C[NH2+]C(C)(C)C FYBXRCFPOTXTJF-UHFFFAOYSA-N 0.000 claims 4
229960002165 carteolol hydrochloride Drugs 0.000 claims 4
KADUHNHNLIGUPU-UHFFFAOYSA-N diethyl 2-(5-aminopyridin-2-yl)-2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=C(N)C=NC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 KADUHNHNLIGUPU-UHFFFAOYSA-N 0.000 claims 4
SQZJVABVAIDAOE-UHFFFAOYSA-N diethyl 2-[2-[2-[2-ethoxy-3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=1OCC)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 SQZJVABVAIDAOE-UHFFFAOYSA-N 0.000 claims 4
CHIDDXJLXFNGCE-UHFFFAOYSA-N diethyl 2-[2-[2-[2-ethoxy-5-methyl-3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=1OCC)=CC(C)=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 CHIDDXJLXFNGCE-UHFFFAOYSA-N 0.000 claims 4
DDHVJBQPFURWLA-UHFFFAOYSA-N diethyl 2-[2-[2-[2-methoxy-3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=1OC)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DDHVJBQPFURWLA-UHFFFAOYSA-N 0.000 claims 4
QYPDKASDOYGDDD-UHFFFAOYSA-N diethyl 2-[2-[2-[2-methoxycarbonyl-3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=1C(=O)OC)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QYPDKASDOYGDDD-UHFFFAOYSA-N 0.000 claims 4
VWQDSJYQZGFUSZ-UHFFFAOYSA-N diethyl 2-[2-[2-[2-methyl-3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=1C)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VWQDSJYQZGFUSZ-UHFFFAOYSA-N 0.000 claims 4
DGZFWSSCJDGXTC-UHFFFAOYSA-N diethyl 2-[2-[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DGZFWSSCJDGXTC-UHFFFAOYSA-N 0.000 claims 4
CYHJKLKOINRIOD-UHFFFAOYSA-N diethyl 2-[2-[2-[4-methyl-3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=1)=CC=C(C)C=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 CYHJKLKOINRIOD-UHFFFAOYSA-N 0.000 claims 4
RQTRHOJDEWHFRL-UHFFFAOYSA-N diethyl 2-[2-[3-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)C(C=C1C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 RQTRHOJDEWHFRL-UHFFFAOYSA-N 0.000 claims 4
VJHDWFVDJGEATB-UHFFFAOYSA-N diethyl 2-[[2-[3-(2-methylpropyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1CC(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VJHDWFVDJGEATB-UHFFFAOYSA-N 0.000 claims 4
RQAZMVFZXSXJJY-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-methyl-6-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=C(C)C=CC=C1C1=CC=C(C(F)(F)F)C=C1 RQAZMVFZXSXJJY-UHFFFAOYSA-N 0.000 claims 4
TXZREXQQNQNFOJ-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC(C)=C1C1=CC=C(C(F)(F)F)C=C1 TXZREXQQNQNFOJ-UHFFFAOYSA-N 0.000 claims 4
ZSFJTLSWCMMWQS-UHFFFAOYSA-N diethyl 2-[[2-[3-methoxy-4-[2-[4-(trifluoromethyl)phenyl]benzoyl]oxyphenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1OC)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZSFJTLSWCMMWQS-UHFFFAOYSA-N 0.000 claims 4
UVHXVZOIYJACHE-UHFFFAOYSA-N diethyl 2-phenyl-2-[2-[2-[2-propan-2-yloxy-3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=1OC(C)C)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UVHXVZOIYJACHE-UHFFFAOYSA-N 0.000 claims 4
BWHGOSZWMINABQ-UHFFFAOYSA-N diethyl 2-phenyl-2-[2-[2-[3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=1)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BWHGOSZWMINABQ-UHFFFAOYSA-N 0.000 claims 4
XVWQQOWBXHBGER-UHFFFAOYSA-N diethyl 2-phenyl-2-[2-[4-[2-[4-(trifluoromethyl)phenyl]benzoyl]oxybenzoyl]oxyethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)C(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XVWQQOWBXHBGER-UHFFFAOYSA-N 0.000 claims 4
ZIEUWIULPTZRJN-UHFFFAOYSA-N diethyl 2-phenyl-2-[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoyl]oxyethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZIEUWIULPTZRJN-UHFFFAOYSA-N 0.000 claims 4
OHSMIXHPCYFYCG-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-(piperidine-1-carbonyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N2CCCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 OHSMIXHPCYFYCG-UHFFFAOYSA-N 0.000 claims 4
LZKKTMHAHINRDI-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-(trifluoromethyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(F)(F)F)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 LZKKTMHAHINRDI-UHFFFAOYSA-N 0.000 claims 4
VLJGRMJIKDOEFT-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=1)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VLJGRMJIKDOEFT-UHFFFAOYSA-N 0.000 claims 4
HSXVEGHKRDFWIU-UHFFFAOYSA-N ethyl 5-[2-[3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropoxy]-2-oxoethyl]-2-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)OCC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 HSXVEGHKRDFWIU-UHFFFAOYSA-N 0.000 claims 4
229940125396 insulin Drugs 0.000 claims 4
229960001300 metoprolol tartrate Drugs 0.000 claims 4
DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 4
229960002289 nicardipine hydrochloride Drugs 0.000 claims 4
AIKVCUNQWYTVTO-UHFFFAOYSA-N nicardipine hydrochloride Chemical compound Cl.COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 AIKVCUNQWYTVTO-UHFFFAOYSA-N 0.000 claims 4
229960001597 nifedipine Drugs 0.000 claims 4
HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims 4
239000008194 pharmaceutical composition Substances 0.000 claims 4
229960004604 propranolol hydrochloride Drugs 0.000 claims 4
AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol hydrochloride Natural products C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims 4
210000000813 small intestine Anatomy 0.000 claims 4
WUBVEMGCQRSBBT-UHFFFAOYSA-N tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(OS(=O)(=O)C(F)(F)F)=CC1 WUBVEMGCQRSBBT-UHFFFAOYSA-N 0.000 claims 4
CGQWKGASBJMXHM-UHFFFAOYSA-N (1-phenylcyclopentyl)methyl 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC1(C=2C=CC=CC=2)CCCC1 CGQWKGASBJMXHM-UHFFFAOYSA-N 0.000 claims 3
GJRYCURWLNPQDI-UHFFFAOYSA-N (1-phenylcyclopropyl)methyl 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC1(C=2C=CC=CC=2)CC1 GJRYCURWLNPQDI-UHFFFAOYSA-N 0.000 claims 3
NWTJZISLLRPHOQ-UHFFFAOYSA-N (2-ethyl-2-phenylbutyl) 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(CC)(CC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NWTJZISLLRPHOQ-UHFFFAOYSA-N 0.000 claims 3
HFRPLILAGQVYSB-UHFFFAOYSA-N 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 HFRPLILAGQVYSB-UHFFFAOYSA-N 0.000 claims 3
WYONJIPEZCTNQA-UHFFFAOYSA-N 5-[2-[3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropoxy]-2-oxoethyl]-2-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoic acid Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(O)=O)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WYONJIPEZCTNQA-UHFFFAOYSA-N 0.000 claims 3
MOPZIIVTOPWMPR-UHFFFAOYSA-N [3-acetyloxy-2-(acetyloxymethyl)-2-phenylpropyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC(COC(C)=O)(COC(C)=O)C1=CC=CC=C1 MOPZIIVTOPWMPR-UHFFFAOYSA-N 0.000 claims 3
VCJSMQOVBIPWRL-UHFFFAOYSA-N [3-hydroxy-2-(hydroxymethyl)-2-phenylpropyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC(CO)(CO)C1=CC=CC=C1 VCJSMQOVBIPWRL-UHFFFAOYSA-N 0.000 claims 3
DOBZQVMLNFFOHW-UHFFFAOYSA-N [4-oxo-3,3-diphenyl-4-(2,2,2-trifluoroethylamino)butyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)NCC(F)(F)F)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DOBZQVMLNFFOHW-UHFFFAOYSA-N 0.000 claims 3
WTVHRXVSMGLFJD-UHFFFAOYSA-N [4-oxo-3-phenyl-4-(propan-2-ylamino)-3-(propan-2-ylcarbamoyl)butyl] 2-[3-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NC(C)C)(C(=O)NC(C)C)CCOC(=O)CC(C=1)=CC=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WTVHRXVSMGLFJD-UHFFFAOYSA-N 0.000 claims 3
239000002253 acid Substances 0.000 claims 3
125000003545 alkoxy group Chemical group 0.000 claims 3
239000002775 capsule Substances 0.000 claims 3
125000004093 cyano group Chemical group *C#N 0.000 claims 3
MVLYOUJBOXHPKU-UHFFFAOYSA-N diethyl 2-[2-[2-[2-methyl-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C(=CC=1)C)=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 MVLYOUJBOXHPKU-UHFFFAOYSA-N 0.000 claims 3
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229960004580 glibenclamide Drugs 0.000 claims 2
229960000346 gliclazide Drugs 0.000 claims 2
229960004346 glimepiride Drugs 0.000 claims 2
WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 claims 2
ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 claims 2
229950002888 glyclopyramide Drugs 0.000 claims 2
KLZWOWYOHUKJIG-BPUTZDHNSA-N imidapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1C(N(C)C[C@H]1C(O)=O)=O)CC1=CC=CC=C1 KLZWOWYOHUKJIG-BPUTZDHNSA-N 0.000 claims 2
229960003409 imidapril hydrochloride Drugs 0.000 claims 2
MPGBPFMOOXKQRX-UHFFFAOYSA-N indenolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=C1C=CC2 MPGBPFMOOXKQRX-UHFFFAOYSA-N 0.000 claims 2
230000002401 inhibitory effect Effects 0.000 claims 2
229960003091 labetalol hydrochloride Drugs 0.000 claims 2
229960002394 lisinopril Drugs 0.000 claims 2
RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 claims 2
239000002171 loop diuretic Substances 0.000 claims 2
229960000519 losartan potassium Drugs 0.000 claims 2
229960004844 lovastatin Drugs 0.000 claims 2
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 2
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 2
229960000299 mazindol Drugs 0.000 claims 2
OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 claims 2
229960004329 metformin hydrochloride Drugs 0.000 claims 2
XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 2
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 2
125000001624 naphthyl group Chemical group 0.000 claims 2
229960000698 nateglinide Drugs 0.000 claims 2
OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 claims 2
229960005366 nilvadipine Drugs 0.000 claims 2
229950000754 nipradilol Drugs 0.000 claims 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 claims 2
229960001243 orlistat Drugs 0.000 claims 2
229960004493 penbutolol sulfate Drugs 0.000 claims 2
FEDSNBHHWZEYTP-ZFQYHYQMSA-N penbutolol sulfate Chemical compound OS(O)(=O)=O.CC(C)(C)NC[C@H](O)COC1=CC=CC=C1C1CCCC1.CC(C)(C)NC[C@H](O)COC1=CC=CC=C1C1CCCC1 FEDSNBHHWZEYTP-ZFQYHYQMSA-N 0.000 claims 2
229960003929 perindopril erbumine Drugs 0.000 claims 2
IYNMDWMQHSMDDE-MHXJNQAMSA-N perindopril erbumine Chemical compound CC(C)(C)N.C1CCC[C@@H]2N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H](C(O)=O)C[C@@H]21 IYNMDWMQHSMDDE-MHXJNQAMSA-N 0.000 claims 2
MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical compound C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 claims 2
229960001999 phentolamine Drugs 0.000 claims 2
229960002508 pindolol Drugs 0.000 claims 2
PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 claims 2
229960002827 pioglitazone hydrochloride Drugs 0.000 claims 2
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 2
229960002965 pravastatin Drugs 0.000 claims 2
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 2
WFXFYZULCQKPIP-UHFFFAOYSA-N prazosin hydrochloride Chemical compound [H+].[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 WFXFYZULCQKPIP-UHFFFAOYSA-N 0.000 claims 2
229960002386 prazosin hydrochloride Drugs 0.000 claims 2
229960003042 quinapril hydrochloride Drugs 0.000 claims 2
IBBLRJGOOANPTQ-JKVLGAQCSA-N quinapril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 IBBLRJGOOANPTQ-JKVLGAQCSA-N 0.000 claims 2
125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
229960002855 simvastatin Drugs 0.000 claims 2
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 2
238000006467 substitution reaction Methods 0.000 claims 2
229940124530 sulfonamide Drugs 0.000 claims 2
150000003456 sulfonamides Chemical class 0.000 claims 2
YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 claims 2
229960004084 temocapril Drugs 0.000 claims 2
FIQOFIRCTOWDOW-BJLQDIEVSA-N temocapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C[C@H](SC1)C=1SC=CC=1)=O)CC1=CC=CC=C1 FIQOFIRCTOWDOW-BJLQDIEVSA-N 0.000 claims 2
VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 claims 2
229960001909 terazosin hydrochloride Drugs 0.000 claims 2
229950008411 tilisolol Drugs 0.000 claims 2
229960002277 tolazamide Drugs 0.000 claims 2
OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 claims 2
229960005371 tolbutamide Drugs 0.000 claims 2
229960002051 trandolapril Drugs 0.000 claims 2
229960001130 urapidil Drugs 0.000 claims 2
229960001729 voglibose Drugs 0.000 claims 2
HYIDKCDAAGHEOM-UHFFFAOYSA-N (2-acetamido-2-phenylethyl) 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC(NC(C)=O)C1=CC=CC=C1 HYIDKCDAAGHEOM-UHFFFAOYSA-N 0.000 claims 1
125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
HLUWFXKPBGTSOT-UHFFFAOYSA-N 2-(9h-fluoren-9-yl)ethyl 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC1=CC=C(C(=O)OCCC2C3=CC=CC=C3C3=CC=CC=C32)C=C1 HLUWFXKPBGTSOT-UHFFFAOYSA-N 0.000 claims 1
VOHAROSLRWMMRA-UHFFFAOYSA-N 2-[(2-phenylbenzoyl)amino]ethyl 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC1=CC=C(C(=O)OCCNC(=O)C=2C(=CC=CC=2)C=2C=CC=CC=2)C=C1 VOHAROSLRWMMRA-UHFFFAOYSA-N 0.000 claims 1
CMOFQOJLONIUTN-UHFFFAOYSA-N 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]propanoic acid Chemical compound C1=CC(C(C(O)=O)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 CMOFQOJLONIUTN-UHFFFAOYSA-N 0.000 claims 1
QZJREBZTHNAMSE-UHFFFAOYSA-N 2-[8-(2,2,2-trifluoroethylcarbamoyl)naphthalen-1-yl]ethyl 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=12C(C(=O)NCC(F)(F)F)=CC=CC2=CC=CC=1CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QZJREBZTHNAMSE-UHFFFAOYSA-N 0.000 claims 1
FELAMXYHUCLVLZ-UHFFFAOYSA-N 2-[9-(2,2,2-trifluoroethylcarbamoyl)fluoren-9-yl]ethyl 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]cyclohexane-1-carboxylate Chemical compound C12=CC=CC=C2C2=CC=CC=C2C1(C(=O)NCC(F)(F)F)CCOC(=O)C(CC1)CCC1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FELAMXYHUCLVLZ-UHFFFAOYSA-N 0.000 claims 1
JOWQZUCFXSAJGN-UHFFFAOYSA-N 2-[9-(2,2,2-trifluoroethylcarbamoyl)fluoren-9-yl]ethyl 4-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]cyclohexane-1-carboxylate Chemical compound C1CC(C(=O)OCCC2(C(=O)NCC(F)(F)F)C3=CC=CC=C3C3=CC=CC=C32)CCC1(C)NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JOWQZUCFXSAJGN-UHFFFAOYSA-N 0.000 claims 1
VTSSCHXVHPNDFN-UHFFFAOYSA-N 2-[[2-(2-phenylphenyl)acetyl]amino]ethyl 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC1=CC=C(C(=O)OCCNC(=O)CC=2C(=CC=CC=2)C=2C=CC=CC=2)C=C1 VTSSCHXVHPNDFN-UHFFFAOYSA-N 0.000 claims 1
239000005711 Benzoic acid Substances 0.000 claims 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
GODWMOBMYQRTAG-UHFFFAOYSA-N [1-(2,2,2-trifluoroethylcarbamoyl)cyclohexyl]methyl 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C=CC=1CC(=O)OCC1(C(=O)NCC(F)(F)F)CCCCC1 GODWMOBMYQRTAG-UHFFFAOYSA-N 0.000 claims 1
SBVWPGZCFISZJO-UHFFFAOYSA-N [1-(2,2,2-trifluoroethylcarbamoyl)cyclopentyl]methyl 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C=CC=1CC(=O)OCC1(C(=O)NCC(F)(F)F)CCCC1 SBVWPGZCFISZJO-UHFFFAOYSA-N 0.000 claims 1
WYSXDUDZIZCIDS-UHFFFAOYSA-N [2-(2,5-dioxopyrrolidin-1-yl)-2-phenylethyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC(C=1C=CC=CC=1)N1C(=O)CCC1=O WYSXDUDZIZCIDS-UHFFFAOYSA-N 0.000 claims 1
NDSMJXYABVYBBJ-UHFFFAOYSA-N [2-(butanoylamino)-2-phenylethyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(NC(=O)CCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NDSMJXYABVYBBJ-UHFFFAOYSA-N 0.000 claims 1
ILJLCKBLMHWUJV-UHFFFAOYSA-N [2-(ethylamino)-2-oxo-1-phenylethyl] 3-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]propanoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)OC(=O)CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ILJLCKBLMHWUJV-UHFFFAOYSA-N 0.000 claims 1
MKRBVMUFKWAUOX-UHFFFAOYSA-N [2-(ethylcarbamoyl)phenyl]methyl 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound CCNC(=O)C1=CC=CC=C1COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 MKRBVMUFKWAUOX-UHFFFAOYSA-N 0.000 claims 1
ORKNWIYWHTUVHK-UHFFFAOYSA-N [2-(methanesulfonamido)-2-phenylethyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC(NS(C)(=O)=O)C1=CC=CC=C1 ORKNWIYWHTUVHK-UHFFFAOYSA-N 0.000 claims 1
CHYOBTQXSFBZHG-UHFFFAOYSA-N [2-[2-(ethylamino)-2-oxoethyl]phenyl]methyl 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound CCNC(=O)CC1=CC=CC=C1COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 CHYOBTQXSFBZHG-UHFFFAOYSA-N 0.000 claims 1
ZWFSLJZDLSOHKD-UHFFFAOYSA-N [2-[methyl(propanoyl)amino]-2-phenylethyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(N(C)C(=O)CC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZWFSLJZDLSOHKD-UHFFFAOYSA-N 0.000 claims 1
WPHZSDSUNGMDNZ-UHFFFAOYSA-N [2-phenyl-2-(propan-2-ylamino)ethyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate;hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(NC(C)C)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WPHZSDSUNGMDNZ-UHFFFAOYSA-N 0.000 claims 1
VJDWXCWQEQIFJZ-UHFFFAOYSA-N [3-(2,6-dichlorophenyl)-4-oxo-4-(2,2,2-trifluoroethylamino)butyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound ClC=1C=CC=C(Cl)C=1C(C(=O)NCC(F)(F)F)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VJDWXCWQEQIFJZ-UHFFFAOYSA-N 0.000 claims 1
BPLVAFMVFAJOGK-UHFFFAOYSA-N [3-(2-chlorophenyl)-4-oxo-4-(2,2,2-trifluoroethylamino)butyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=C(Cl)C=1C(C(=O)NCC(F)(F)F)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BPLVAFMVFAJOGK-UHFFFAOYSA-N 0.000 claims 1
LSJLNLNWHYUKJR-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[2-oxo-3-[2-[4-(trifluoromethyl)phenyl]benzoyl]-1,3-benzoxazol-6-yl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1OC2=O)=CC=C1N2C(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 LSJLNLNWHYUKJR-UHFFFAOYSA-N 0.000 claims 1
UOKSKZNYBWHXON-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(dimethylcarbamoyl)-4-[(2-phenoxybenzoyl)amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1OC1=CC=CC=C1 UOKSKZNYBWHXON-UHFFFAOYSA-N 0.000 claims 1
BYDQPEFBPAESBC-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(dimethylcarbamoyl)-4-[[2-(trifluoromethyl)benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C(F)(F)F BYDQPEFBPAESBC-UHFFFAOYSA-N 0.000 claims 1
VJHHHBDLWMIOMA-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-methyl-4-[[2-[4-(trifluoromethyl)phenyl]pyridine-3-carbonyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C)=CC=C1NC(=O)C1=CC=CN=C1C1=CC=C(C(F)(F)F)C=C1 VJHHHBDLWMIOMA-UHFFFAOYSA-N 0.000 claims 1
CUHMEEJBZYGMNF-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[(2-benzoylbenzoyl)amino]-3-(dimethylcarbamoyl)phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C(=O)C1=CC=CC=C1 CUHMEEJBZYGMNF-UHFFFAOYSA-N 0.000 claims 1
YAUAWEWFZGWJAX-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[(2-butoxybenzoyl)amino]phenyl]acetate Chemical compound CCCCOC1=CC=CC=C1C(=O)NC(C=C1)=CC=C1CC(=O)OCC(C(=O)NCC)(C(=O)NCC)C1=CC=CC=C1 YAUAWEWFZGWJAX-UHFFFAOYSA-N 0.000 claims 1
MXYXPBBVTRTDGP-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[(2-cyclohexylbenzoyl)amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1CCCCC1 MXYXPBBVTRTDGP-UHFFFAOYSA-N 0.000 claims 1
NWCPRIHQBYCHFI-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[(2-phenoxybenzoyl)amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1OC1=CC=CC=C1 NWCPRIHQBYCHFI-UHFFFAOYSA-N 0.000 claims 1
IYFOZRJGCONHSL-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]pyridine-3-carbonyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CN=C1C1=CC=C(C(F)(F)F)C=C1 IYFOZRJGCONHSL-UHFFFAOYSA-N 0.000 claims 1
LGIWMMZXYVYWLD-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-methyl-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbonyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C1=CC=C(C(F)(F)F)C=C1 LGIWMMZXYVYWLD-UHFFFAOYSA-N 0.000 claims 1
DTGAQZLPDGVICO-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 4-[[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]methyl]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)C(C=C1)=CC=C1CNC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DTGAQZLPDGVICO-UHFFFAOYSA-N 0.000 claims 1
IZIWDYQEDGCNHT-UHFFFAOYSA-N [3-(ethylamino)-3-oxo-2-phenylpropyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 IZIWDYQEDGCNHT-UHFFFAOYSA-N 0.000 claims 1
NMNZOMPKESKEMF-UHFFFAOYSA-N [3-naphthalen-1-yl-4-oxo-4-(2,2,2-trifluoroethylamino)butyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC2=CC=CC=C2C=1C(C(=O)NCC(F)(F)F)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NMNZOMPKESKEMF-UHFFFAOYSA-N 0.000 claims 1
AZZGVQVTSSWDMP-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)-2-(2,2,2-trifluoroethylcarbamoyl)propyl] 2-[4-[(2-butoxybenzoyl)amino]phenyl]acetate Chemical compound CCCCOC1=CC=CC=C1C(=O)NC(C=C1)=CC=C1CC(=O)OCC(C(=O)NCC(F)(F)F)(C(=O)NCC(F)(F)F)C1=CC=CC=C1 AZZGVQVTSSWDMP-UHFFFAOYSA-N 0.000 claims 1
IWYLIQWGGFNCJX-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)-2-(2,2,2-trifluoroethylcarbamoyl)propyl] 2-[4-[(2-phenoxybenzoyl)amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)(C(=O)NCC(F)(F)F)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1OC1=CC=CC=C1 IWYLIQWGGFNCJX-UHFFFAOYSA-N 0.000 claims 1
NWHUYASNTIKNOX-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)propyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NWHUYASNTIKNOX-UHFFFAOYSA-N 0.000 claims 1
FVZWNGCZEFEFPP-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(propylamino)-2-(propylcarbamoyl)propyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCC)(C(=O)NCCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FVZWNGCZEFEFPP-UHFFFAOYSA-N 0.000 claims 1
FTSDHRXEBBGYLK-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 3-[[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]methyl]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)C(C=1)=CC=CC=1CNC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FTSDHRXEBBGYLK-UHFFFAOYSA-N 0.000 claims 1
BBUZYIVSENWEQE-UHFFFAOYSA-N [4-[2-oxo-2-[3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)-2-(2,2,2-trifluoroethylcarbamoyl)propoxy]ethyl]phenyl] 2-butoxybenzoate Chemical compound CCCCOC1=CC=CC=C1C(=O)OC(C=C1)=CC=C1CC(=O)OCC(C(=O)NCC(F)(F)F)(C(=O)NCC(F)(F)F)C1=CC=CC=C1 BBUZYIVSENWEQE-UHFFFAOYSA-N 0.000 claims 1
VYDHPNAPJHQGAQ-UHFFFAOYSA-N [4-oxo-3-phenyl-4-(2,2,2-trifluoroethylamino)butyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VYDHPNAPJHQGAQ-UHFFFAOYSA-N 0.000 claims 1
GRTJXBFALVCJGQ-UHFFFAOYSA-N [4-oxo-3-phenyl-4-(2,2,2-trifluoroethylamino)butyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]cyclohexane-1-carboxylate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)CCOC(=O)C(CC1)CCC1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 GRTJXBFALVCJGQ-UHFFFAOYSA-N 0.000 claims 1
YBCUOOHHOIJDSW-UHFFFAOYSA-N [9-(2,2,2-trifluoroethylcarbamoyl)fluoren-9-yl]methyl 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]propanoate Chemical compound C12=CC=CC=C2C2=CC=CC=C2C1(C(=O)NCC(F)(F)F)COC(=O)C(C)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 YBCUOOHHOIJDSW-UHFFFAOYSA-N 0.000 claims 1
125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
125000003277 amino group Chemical group 0.000 claims 1
230000003579 anti-obesity Effects 0.000 claims 1
239000000883 anti-obesity agent Substances 0.000 claims 1
239000003524 antilipemic agent Substances 0.000 claims 1
229940125710 antiobesity agent Drugs 0.000 claims 1
125000004429 atom Chemical group 0.000 claims 1
239000004305 biphenyl Substances 0.000 claims 1
235000010290 biphenyl Nutrition 0.000 claims 1
AHEJHFCCIIXDLZ-UHFFFAOYSA-N diethyl 2-[2-[4-(2-benzoylbenzoyl)oxybenzoyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)C(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C(=O)C1=CC=CC=C1 AHEJHFCCIIXDLZ-UHFFFAOYSA-N 0.000 claims 1
GHULWLVRNBPYGI-UHFFFAOYSA-N diethyl 2-[[2-[2-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CN(C1=CC=C2)C(C)=NC1=C2NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 GHULWLVRNBPYGI-UHFFFAOYSA-N 0.000 claims 1
JDYPGORKZUILES-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[(2-phenoxybenzoyl)amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1OC1=CC=CC=C1 JDYPGORKZUILES-UHFFFAOYSA-N 0.000 claims 1
OMGOECIYVOQHEI-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-(trifluoromethyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C(F)(F)F OMGOECIYVOQHEI-UHFFFAOYSA-N 0.000 claims 1
BYWLAFOFYPDVEN-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[3-(trifluoromethyl)anilino]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 BYWLAFOFYPDVEN-UHFFFAOYSA-N 0.000 claims 1
VMBFKPDGSCGSKF-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[3-(trifluoromethyl)phenoxy]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1OC1=CC=CC(C(F)(F)F)=C1 VMBFKPDGSCGSKF-UHFFFAOYSA-N 0.000 claims 1
CNSUYALGSDGSSC-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenoxy]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1OC1=CC=C(C(F)(F)F)C=C1 CNSUYALGSDGSSC-UHFFFAOYSA-N 0.000 claims 1
OFUDQCHXORBKIQ-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-prop-1-en-2-yl-4-(trifluoromethyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1C(C)=C OFUDQCHXORBKIQ-UHFFFAOYSA-N 0.000 claims 1
AVNPLYVXSZMDCK-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-propan-2-yl-4-(trifluoromethyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1C(C)C AVNPLYVXSZMDCK-UHFFFAOYSA-N 0.000 claims 1
LFDCUYUOQJUJDA-UHFFFAOYSA-N diethyl 2-[[2-[4-(2-benzoylbenzoyl)oxyphenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C(=O)C1=CC=CC=C1 LFDCUYUOQJUJDA-UHFFFAOYSA-N 0.000 claims 1
TUFCFZKRAVFRTK-UHFFFAOYSA-N diethyl 2-[[2-[4-(9h-fluorene-1-carbonylamino)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=C(NC(=O)C=2C3=C(C4=CC=CC=C4C3)C=CC=2)C=CC=1CC(=O)OCC(C(=O)OCC)(C(=O)OCC)C1=CC=CC=C1 TUFCFZKRAVFRTK-UHFFFAOYSA-N 0.000 claims 1
UBTRBJLMJHHSGP-UHFFFAOYSA-N diethyl 2-[[2-[4-[(2-benzoylbenzoyl)amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C(=O)C1=CC=CC=C1 UBTRBJLMJHHSGP-UHFFFAOYSA-N 0.000 claims 1
LLGYUDLFSGRVNF-UHFFFAOYSA-N diethyl 2-[[2-[4-[(2-benzoylbenzoyl)amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C(=O)C1=CC=CC=C1 LLGYUDLFSGRVNF-UHFFFAOYSA-N 0.000 claims 1
ZTDIJXOABCWAEX-UHFFFAOYSA-N diethyl 2-[[2-[4-[(2-butoxybenzoyl)amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound CCCCOC1=CC=CC=C1C(=O)NC(C=C1)=CC=C1CC(=O)OCC(C(=O)OCC)(C(=O)OCC)C1=CC=CC=C1 ZTDIJXOABCWAEX-UHFFFAOYSA-N 0.000 claims 1
QBDAFLZDGLFINO-UHFFFAOYSA-N diethyl 2-[[2-[4-[(2-butoxycarbonylbenzoyl)amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)NC(C=C1)=CC=C1CC(=O)OCC(C(=O)OCC)(C(=O)OCC)C1=CC=CC=C1 QBDAFLZDGLFINO-UHFFFAOYSA-N 0.000 claims 1
ALCCRPRDCBCQKW-UHFFFAOYSA-N diethyl 2-[[2-[4-[(2-phenoxybenzoyl)amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1OC1=CC=CC=C1 ALCCRPRDCBCQKW-UHFFFAOYSA-N 0.000 claims 1
TXJZLTZBWILVJQ-UHFFFAOYSA-N diethyl 2-[[2-[4-[(9-oxofluorene-1-carbonyl)amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=C(NC(=O)C=2C=3C(=O)C4=CC=CC=C4C=3C=CC=2)C=CC=1CC(=O)OCC(C(=O)OCC)(C(=O)OCC)C1=CC=CC=C1 TXJZLTZBWILVJQ-UHFFFAOYSA-N 0.000 claims 1
PVGQAMQFNQDXKM-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-fluorobenzoyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C(=O)C1=CC=C(F)C=C1 PVGQAMQFNQDXKM-UHFFFAOYSA-N 0.000 claims 1
UACPWMGZHIMZAC-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-methyl-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbonyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C=1SC(C)=NC=1C1=CC=C(C(F)(F)F)C=C1 UACPWMGZHIMZAC-UHFFFAOYSA-N 0.000 claims 1
ZUMZISWSTGEFNI-UHFFFAOYSA-N diethyl 2-phenyl-2-[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]cyclohexanecarbonyl]oxyethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)C(CC1)CCC1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZUMZISWSTGEFNI-UHFFFAOYSA-N 0.000 claims 1
ZVHYDADAYOFBLZ-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[(2-propan-2-ylbenzoyl)amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C(C)C ZVHYDADAYOFBLZ-UHFFFAOYSA-N 0.000 claims 1
OGCIACUCDXTBFI-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[(2-thiophen-3-ylbenzoyl)amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C=1C=CSC=1 OGCIACUCDXTBFI-UHFFFAOYSA-N 0.000 claims 1
SXUZRPFZYIIPOL-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[(3-phenylbenzoyl)amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C(C=1)=CC=CC=1C1=CC=CC=C1 SXUZRPFZYIIPOL-UHFFFAOYSA-N 0.000 claims 1
XBTNYNBNOGFFNV-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[2-(trifluoromethyl)benzoyl]oxyphenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C(F)(F)F XBTNYNBNOGFFNV-UHFFFAOYSA-N 0.000 claims 1
MMPUTRPKTQCFAZ-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[[2-(trifluoromethoxy)benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1OC(F)(F)F MMPUTRPKTQCFAZ-UHFFFAOYSA-N 0.000 claims 1
YRKWCSSPYLPOIG-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[[2-(trifluoromethyl)benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C(F)(F)F YRKWCSSPYLPOIG-UHFFFAOYSA-N 0.000 claims 1
VXFMDJPXDXGORS-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CN(C1=CC=C2)C=NC1=C2NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VXFMDJPXDXGORS-UHFFFAOYSA-N 0.000 claims 1
CKMLTAAXHVBNRX-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indol-1-yl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CN(C1=CC=C2)C=CC1=C2NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 CKMLTAAXHVBNRX-UHFFFAOYSA-N 0.000 claims 1
UNVODLXOVPZMJQ-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CN(CC1)CCC1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UNVODLXOVPZMJQ-UHFFFAOYSA-N 0.000 claims 1
DTUGERSGFRQBQT-UHFFFAOYSA-N diethyl 2-phenyl-2-[[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]cyclohexanecarbonyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)C(CC1)CCC1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DTUGERSGFRQBQT-UHFFFAOYSA-N 0.000 claims 1
FGYDHYCFHBSNPE-UHFFFAOYSA-N diethyl phenylmalonate Chemical compound CCOC(=O)C(C(=O)OCC)C1=CC=CC=C1 FGYDHYCFHBSNPE-UHFFFAOYSA-N 0.000 claims 1
PKOJLUDOEGKHKD-UHFFFAOYSA-N ethyl 3-[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxy-2-phenylpropanoate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 PKOJLUDOEGKHKD-UHFFFAOYSA-N 0.000 claims 1
239000007902 hard capsule Substances 0.000 claims 1
229910052739 hydrogen Inorganic materials 0.000 claims 1
239000001257 hydrogen Substances 0.000 claims 1
230000004060 metabolic process Effects 0.000 claims 1
ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 1
230000003449 preventive effect Effects 0.000 claims 1
239000007901 soft capsule Substances 0.000 claims 1
239000000126 substance Substances 0.000 claims 1

JP2003053869A 2002-02-28 2003-02-28 エステル化合物及びその医薬用途 Expired - Fee Related JP3662566B2 (ja)