JP2003304874A5 - - Google Patents

Description

  [0082]
  [Sequence list]
                         SEQUENCE LISTING
<110>MIYATA, TOSHIYUKI

<120> A Method for testing of thrombophilic diathesis

<130> NCV-A0201


<140>JP 2002-111241
<141>2002-04-12

<160>6     

<170> PatentIn version 2.1


<210> 1
<211> 4933
<212> DNA
<213> Homo sapiens

<400> 1
aaccacgatg tctttggcac agcctctcat ctgtcagatg ggagcgggga ccccggagag 60
ggagtcagcc gaggtcctgg cattccttgt gaacccccgt ctgtgggttt ctggtccagt 120
gtcccttctc cagattagat ggcttaggcc tcctctaagg gggtgggcgt gcacatccgg 180
agagctgtct ggtgtgcagg actgggctgc aggttaccct gaactgcaac catcttagag 240
caaggcccag cttgcagcag gaggagctgc aggccgccca ccctagccac ggcccctgcc 300
ctggcaggaa gcttccaaga gtaaacactg cctaatcgtc ccgcccagta gtgagcaggc 360
ctgtcccatt ccatactgac cagattccca gtcaccaagg ccccctctca ctccgctcca 420
ctcctcgggc tggctctcct gaggatgcac cagcgtcacc cccgggcaag atgccctccc 480
ctctgtgtgg ccggaatcct tgcctgtggc tttctcctgg gctgctgggg accctcccat 540
ttccagcaga gttgtcttca ggctttggag ccacaggccg tgtcttctta cttgagccct 600
ggtgctccct taaaaggccg ccctccttcc cctggcttcc agaggcagag gcagaggcag 660
aggcgggctg caggcggcat cctacacctg gagctgctgg tggccgtggg ccccgatgtc 720
ttccaggctc accaggagga cacagagcgc tatgtgctca ccaacctcaa catcggggca 780
gaactgcttc gggacccgtc cctgggggct cagtttcggg tgcacctggt gaagatggtc 840
attctgacag agcctgaggg tgctccaaat atcacagcca acctcacctc gtccctgctg 900
agcgtctgtg ggtggagcca gaccatcaac cctgaggacg acacggatcc tggccatgct 960
gacctggtcc tctatatcac taggtttgac ctggagttgc ctgatggtaa ccggcaggtg 1020
cggggcgtca cccagctggg cggtgcctgc tccccaacct ggagctgcct cattaccgag 1080
gacactggct tcgacctggg agtcaccatt gcccatgaga ttgggcacag cttcggcctg 1140
gagcacgacg gcgcgcccgg cagcggctgc ggccccagcg gacacgtgat ggcttcggac 1200
ggcgccgcgc cccgcgccgg cctcgcctgg tccccctgca gccgccggca gctgctgagc 1260
ctgctcagcg caggacgggc gcgctgcgtg tgggacccgc cgcggcctca acccgggtcc 1320
gcggggcacc cgccggatgc gcagcctggc ctctactaca gcgccaacga gcagtgccgc 1380
gtggccttcg gccccaaggc tgtcgcctgc accttcgcca gggagcacct ggatatgtgc 1440
caggccctct cctgccacac agacccgctg gaccaaagca gctgcagccg cctcctcgtt 1500
cctctcctgg atgggacaga atgtggcgtg gagaagtggt gctccaaggg tcgctgccgc 1560
tccctggtgg agctgacccc catagcagca gtgcatgggc gctggtctag ctggggtccc 1620
cgaagtcctt gctcccgctc ctgcggagga ggtgtggtca ccaggaggcg gcagtgcaac 1680
aaccccagac ctgcctttgg ggggcgtgca tgtgttggtg ctgacctcca ggccgagatg 1740
tgcaacactc aggcctgcga gaagacccag ctggagttca tgtcgcaaca gtgcgccagg 1800
accgacggcc agccgctgcg ctcctcccct ggcggcgcct ccttctacca ctggggtgct 1860
gctgtaccac acagccaagg ggatgctctg tgcagacaca tgtgccgggc cattggcgag 1920
agcttcatca tgaagcgtgg agacagcttc ctcgatggga cccggtgtat gccaagtggc 1980
ccccgggagg acgggaccct gagcctgtgt gtgtcgggca gctgcaggac atttggctgt 2040
gatggtagga tggactccca gcaggtatgg gacaggtgcc aggtgtgtgg tggggacaac 2100
agcacgtgca gcccacggaa gggctctttc acagctggca gagcgagaga atatgtcacg 2160
tttctgacag ttacccccaa cctgaccagt gtctacattg ccaaccacag gcctctcttc 2220
acacacttgg cggtgaggat cggagggcgc tatgtcgtgg ctgggaagat gagcatctcc 2280
cctaacacca cctacccctc cctcctggag gatggtcgtg tcgagtacag agtggccctc 2340
accgaggacc ggctgccccg cctggaggag atccgcatct ggggacccct ccaggaagat 2400
gctgacatcc aggtttacag gcggtatggc gaggagtatg gcaacctcac ccgcccagac 2460
atcaccttca cctacttcca gcctaagcca cggcaggcct gggtgtgggc cgctgtgcgt 2520
gggccctgct cggtgagctg tggggcaggg ctgcgctggg taaactacag ctgcctggac 2580
caggccagga aggagttggt ggagactgtc cagtgccaag ggagccagca gccaccagcg 2640
tggccagagg cctgcgtgct cgaaccctgc cctccctact gggcggtggg agacttcggc 2700
ccatgcagcg cctcctgtgg gggcggcctg cgggagcggc cagtgcgctg cgtggaggcc 2760
cagggcagcc tcctgaagac attgccccca gcccggtgca gagcaggggc ccagcagcca 2820
gctgtggcgc tggaaacctg caacccccag ccctgccctg ccaggtggga ggtgtcagag 2880
cccagctcat gcacatcagc tggtggagca ggcctggcct tggagaacga gacctgtgtg 2940
ccaggggcag atggcctgga ggctccagtg actgaggggc ctggctccgt agatgagaag 3000
ctgcctgccc ctgagccctg tgtcgggatg tcatgtcctc caggctgggg ccatctggat 3060
gccacctctg caggggagaa ggctccctcc ccatggggca gcatcaggac gggggctcaa 3120
gctgcacacg tgtggacccc tgcggcaggg tcgtgctccg tctcctgcgg gcgaggtctg 3180
atggagctgc gtttcctgtg catggactct gccctcaggg tgcctgtcca ggaagagctg 3240
tgtggcctgg caagcaagcc tgggagccgg cgggaggtct gccaggctgt cccgtgccct 3300
gctcggtggc agtacaagct ggcggcctgc agcgtgagct gtgggagagg ggtcgtgcgg 3360
aggatcctgt attgtgcccg ggcccatggg gaggacgatg gtgaggagat cctgttggac 3420
acccagtgcc aggggctgcc tcgcccggaa ccccaggagg cctgcagcct ggagccctgc 3480
ccacctaggt ggaaagtcat gtcccttggc ccatgttcgg ccagctgtgg ccttggcact 3540
gctagacgct cggtggcctg tgtgcagctc gaccaaggcc aggacgtgga ggtggacgag 3600
gcggcctgtg cggcgctggt gcggcccgag gccagtgtcc cctgtctcat tgccgactgc 3660
acctaccgct ggcatgttgg cacctggatg gagtgctctg tttcctgtgg ggatggcatc 3720
cagcgccggc gtgacacctg cctcggaccc caggcccagg cgcctgtgcc agctgatttc 3780
tgccagcact tgcccaagcc ggtgactgtg cgtggctgct gggctgggcc ctgtgtggga 3840
cagggtacgc ccagcctggt gccccacgaa gaagccgctg ctccaggacg gaccacagcc 3900
acccctgctg gtgcctccct ggagtggtcc caggcccggg gcctgctctt ctccccggct 3960
ccccagcctc ggcggctcct gcccgggccc caggaaaact cagtgcagtc cagtgcctgt 4020
ggcaggcagc accttgagcc aacaggaacc attgacatgc gaggcccagg gcaggcagac 4080
tgtgcagtgg ccattgggcg gcccctcggg gaggtggtga ccctccgcgt ccttgagagt 4140
tctctcaact gcagtgcggg ggacatgttg ctgctttggg gccggctcac ctggaggaag 4200
atgtgcagga agctgttgga catgactttc agctccaaga ccaacacgct ggtggtgagg 4260
cagcgctgcg ggcggccagg aggtggggtg ctgctgcggt atgggagcca gcttgctcct 4320
gaaaccttct acagagaatg tgacatgcag ctctttgggc cctggggtga aatcgtgagc 4380
ccctcgctga gtccagccac gagtaatgca gggggctgcc ggctcttcat taatgtggct 4440
ccgcacgcac ggattgccat ccatgccctg gccaccaaca tgggcgctgg gaccgaggga 4500
gccaatgcca gctacatctt gatccgggac acccacagct tgaggaccac agcgttccat 4560
gggcagcagg tgctctactg ggagtcagag agcagccagg ctgagatgga gttcagcgag 4620
ggcttcctga aggctcaggc cagcctgcgg ggccagtact ggaccctcca atcatgggta 4680
ccggagatgc aggaccctca gtcctggaag ggaaaggaag gaacctgagg gtcattgaac 4740
atttgttccg tgtctggcca gccctggagg gttgacccct ggtctcagtg ctttccaatt 4800
cgaacttttt ccaatcttag gtatctactt tagagtcttc tccaatgtcc aaaaggctag 4860
ggggttggag gtggggactc tggaaaagca gcccccattt cctcgggtac caataaataa 4920
aacatgcagg ctg 4933


<210> 2
<211> 1427
<212> PRT
<213> Homo sapiens

<400> 2
Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala
1 5 10 15
Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His
            20 25 30
Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser
        35 40 45
Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly
    50 55 60
Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu
65 70 75 80
His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His
                85 90 95
Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala
            100 105 110
Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu
        115 120 125
Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr
    130 135 140
Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr
145 150 155 160
Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu
                165 170 175
Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val
            180 185 190
Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys
        195 200 205
Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His
    210 215 220
Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser
225 230 235 240
Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro
                245 250 255
Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser
            260 265 270
Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro
        275 280 285
Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr
    290 295 300
Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val
305 310 315 320
Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser
                325 330 335
Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val
            340 345 350
Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys
        355 360 365
Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His
    370 375 380
Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys
385 390 395 400
Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro
                405 410 415
Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met
            420 425 430
Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln
        435 440 445
Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly
    450 455 460
Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp
465 470 475 480
Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met
                485 490 495
Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly
            500 505 510
Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg
        515 520 525
Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg
    530 535 540
Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly
545 550 555 560
Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val
                565 570 575
Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe
            580 585 590
Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys
        595 600 605
Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly
    610 615 620
Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu
625 630 635 640
Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln
                645 650 655
Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp
            660 665 670
Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp
        675 680 685
Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg
    690 695 700
Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu
705 710 715 720
Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala
                725 730 735
Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly
            740 745 750
Pro Cys Ser Ala Ser Cys Gly Gly Gly Gly Leu Arg Glu Arg Pro Val Arg
        755 760 765
Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg
    770 775 780
Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn
785 790 795 800
Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys
                805 810 815
Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val
            820 825 830
Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser
        835 840 845
Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys
    850 855 860
Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala
865 870 875 880
Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val
                885 890 895
Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu
            900 905 910
Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val
        915 920 925
Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu
    930 935 940
Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala
945 950 955 960
Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr
                965 970 975
Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp
            980 985 990
Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln Glu Ala Cys Ser
        995 1000 1005
Leu Glu Pro Cys Pro Pro Arg Trp Lys Val Met Ser Leu Gly Pro
    1010 1015 1020
Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg Arg Ser Val Ala
    1025 1030 1035
Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val Asp Glu Ala
    1040 1045 1050
Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro Cys Leu
    1055 1060 1065
Ile Ala Asp Cys Thr Tyr Arg Trp His Val Gly Thr Trp Met Glu
    1070 1075 1080
Cys Ser Val Ser Cys Gly Asp Gly Ile Gln Arg Arg Arg Asp Thr
    1085 1090 1095
Cys Leu Gly Pro Gln Ala Gln Ala Pro Val Pro Ala Asp Phe Cys
    1100 1105 1110
Gln His Leu Pro Lys Pro Val Thr Val Arg Gly Cys Trp Ala Gly
    1115 1120 1125
Pro Cys Val Gly Gln Gly Thr Pro Ser Leu Val Pro His Glu Glu
    1130 1135 1140
Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser
    1145 1150 1155
Leu Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro
    1160 1165 1170
Gln Pro Arg Arg Leu Leu Pro Gly Pro Gln Glu Asn Ser Val Gln
    1175 1180 1185
Ser Ser Ala Cys Gly Arg Gln His Leu Glu Pro Thr Gly Thr Ile
    1190 1195 1200
Asp Met Arg Gly Pro Gly Gln Ala Asp Cys Ala Val Ala Ile Gly
    1205 1210 1215
Arg Pro Leu Gly Glu Val Val Thr Leu Arg Val Leu Glu Ser Ser
    1220 1225 1230
Leu Asn Cys Ser Ala Gly Asp Met Leu Leu Leu Trp Gly Arg Leu
    1235 1240 1245
Thr Trp Arg Lys Met Cys Arg Lys Leu Leu Asp Met Thr Phe Ser
    1250 1255 1260
Ser Lys Thr Asn Thr Leu Val Val Arg Gln Arg Cys Gly Arg Pro
    1265 1270 1275
Gly Gly Gly Val Leu Leu Arg Tyr Gly Ser Gln Leu Ala Pro Glu
    1280 1285 1290
Thr Phe Tyr Arg Glu Cys Asp Met Gln Leu Phe Gly Pro Trp Gly
    1295 1300 1305
Glu Ile Val Ser Pro Ser Leu Ser Pro Ala Thr Ser Asn Ala Gly
    1310 1315 1320
Gly Cys Arg Leu Phe Ile Asn Val Ala Pro His Ala Arg Ile Ala
    1325 1330 1335
Ile His Ala Leu Ala Thr Asn Met Gly Ala Gly Thr Glu Gly Ala
    1340 1345 1350
Asn Ala Ser Tyr Ile Leu Ile Arg Asp Thr His Ser Leu Arg Thr
    1355 1360 1365
Thr Ala Phe His Gly Gln Gln Val Leu Tyr Trp Glu Ser Glu Ser
    1370 1375 1380
Ser Gln Ala Glu Met Glu Phe Ser Glu Gly Phe Leu Lys Ala Gln
    1385 1390 1395
Ala Ser Leu Arg Gly Gln Tyr Trp Thr Leu Gln Ser Trp Val Pro
    1400 1405 1410
Glu Met Gln Asp Pro Gln Ser Trp Lys Gly Lys Glu Gly Thr
    1415 1420 1425


<210> 3
<211> 4933
<212> DNA
<213> Homo sapiens

<220>
<221> CDS
<222> (445) .. (4728)

<400> 3
aaccacgatg tctttggcac agcctctcat ctgtcagatg ggagcgggga ccccggagag 60
ggagtcagcc gaggtcctgg cattccttgt gaacccccgt ctgtgggttt ctggtccagt 120
gtcccttctc cagattagat ggcttaggcc tcctctaagg gggtgggcgt gcacatccgg 180
agagctgtct ggtgtgcagg actgggctgc aggttaccct gaactgcaac catcttagag 240
caaggcccag cttgcagcag gaggagctgc aggccgccca ccctagccac ggcccctgcc 300
ctggcaggaa gcttccaaga gtaaacactg cctaatcgtc ccgcccagta gtgagcaggc 360
ctgtcccatt ccatactgac cagattccca gtcaccaagg ccccctctca ctccgctcca 420

ctcctcgggc tggctctcct gagg atg cac cag cgt cac ccc cgg gca aga 471
                           Met His Gln Arg His Pro Arg Ala Arg
                           1 5
tgc cct ccc ctc tgt gtg gcc gga atc ctt gcc tgt ggc ttt ctc ctg 519
Cys Pro Pro Leu Cys Val Ala Gly Ile Leu Ala Cys Gly Phe Leu Leu
10 15 20 25
ggc tgc tgg gga ccc tcc cat ttc cag cag agt tgt ctt cag gct ttg 567
Gly Cys Trp Gly Pro Ser His Phe Gln Gln Ser Cys Leu Gln Ala Leu
                30 35 40
gag cca cag gcc gtg tct tct tac ttg agc cct ggt gct ccc tta aaa 615
Glu Pro Gln Ala Val Ser Ser Tyr Leu Ser Pro Gly Ala Pro Leu Lys
            45 50 55
ggc cgc cct cct tcc cct ggc ttc cag agg cag agg cag agg cag agg 663
Gly Arg Pro Pro Ser Pro Gly Phe Gln Arg Gln Arg Gln Arg Gln Arg
        60 65 70
cgg gct gca ggc ggc atc cta cac ctg gag ctg ctg gtg gcc gtg ggc 711
Arg Ala Ala Gly Gly Ile Leu His Leu Glu Leu Leu Val Ala Val Gly
    75 80 85
ccc gat gtc ttc cag gct cac cag gag gac aca gag cgc tat gtg ctc 759
Pro Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg Tyr Val Leu
90 95 100 105
acc aac ctc aac atc ggg gca gaa ctg ctt cgg gac ccg tcc ctg ggg 807
Thr Asn Leu Asn Ile Gly Ala Glu Leu Leu Arg Asp Pro Ser Leu Gly
                110 115 120
gct cag ttt cgg gtg cac ctg gtg aag atg gtc att ctg aca gag cct 855
Ala Gln Phe Arg Val His Leu Val Lys Met Val Ile Leu Thr Glu Pro
            125 130 135
gag ggt gct cca aat atc aca gcc aac ctc acc tcg tcc ctg ctg agc 903
Glu Gly Ala Pro Asn Ile Thr Ala Asn Leu Thr Ser Ser Leu Leu Ser
        140 145 150
gtc tgt ggg tgg agc cag acc atc aac cct gag gac gac acg gat cct 951
Val Cys Gly Trp Ser Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro
    155 160 165
ggc cat gct gac ctg gtc ctc tat atc act agg ttt gac ctg gag ttg 999
Gly His Ala Asp Leu Val Leu Tyr Ile Thr Arg Phe Asp Leu Glu Leu
170 175 180 185
cct gat ggt aac cgg cag gtg cgg ggc gtc acc cag ctg ggc ggt gcc 1047
Pro Asp Gly Asn Arg Gln Val Arg Gly Val Thr Gln Leu Gly Gly Ala
                190 195 200
tgc tcc cca acc tgg agc tgc ctc att acc gag gac act ggc ttc gac 1095
Cys Ser Pro Thr Trp Ser Cys Leu Ile Thr Glu Asp Thr Gly Phe Asp
            205 210 215
ctg gga gtc acc att gcc cat gag att ggg cac agc ttc ggc ctg gag 1143
Leu Gly Val Thr Ile Ala His Glu Ile Gly His Ser Phe Gly Leu Glu
        220 225 230
cac gac ggc gcg ccc ggc agc ggc tgc ggc ccc agc gga cac gtg atg 1191
His Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser Gly His Val Met
    235 240 245
gct tcg gac ggc gcc gcg ccc cgc gcc ggc ctc gcc tgg tcc ccc tgc 1239
Ala Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro Cys
250 255 260 265
agc cgc cgg cag ctg ctg agc ctg ctc agc gca gga cgg gcg cgc tgc 1287
Ser Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg Cys
                270 275 280
ggt tgg gac ccg ccg cgg cct caa ccc ggg tcc gcg ggg cac ccg ccg 1335
Val Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro Pro
            285 290 295
gat gcg cag cct ggc ctc tac tac agc gcc aac gag cag tgc cgc gtg 1383
Asp Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg Val
        300 305 310
gcc ttc ggc ccc aag gct gtc gcc tgc acc ttc gcc agg gag cac ctg 1431
Ala Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His Leu
    315 320 325
gat atg tgc cag gcc ctc tcc tgc cac aca gac ccg ctg gac caa agc 1479
Asp Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser
330 335 340 345
agc tgc agc cgc ctc ctc gtt cct ctc ctg gat ggg aca gaa tgt ggc 1527
Ser Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly
                350 355 360
gtg gag aag tgg tgc tcc aag ggt cgc tgc cgc tcc ctg gtg gag ctg 1575
Val Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu
            365 370 375
acc ccc ata gca gca gtg cat ggg cgc tgg tct agc tgg ggt ccc cga 1623
Thr Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg
        380 385 390
agt cct tgc tcc cgc tcc tgc gga gga ggt gtg gtc acc agg agg cgg 1671
Ser Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg
    395 400 405
cag tgc aac aac ccc aga cct gcc ttt ggg ggg cgt gca tgt gtt ggt 1719
Gln Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly
410 415 420 425
gct gac ctc cag gcc gag atg tgc aac act cag gcc tgc gag aag acc 1767
Ala Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr
                430 435 440
cag ctg gag ttc atg tcg caa cag tgc gcc agg acc gac ggc cag ccg 1815
Gln Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro
            445 450 455
ctg cgc tcc tcc cct ggc ggc gcc tcc ttc tac cac tgg ggt gct gct 1863
Leu Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala
        460 465 470
gta tca cac agc caa ggg gat gct ctg tgc aga cac atg tgc cgg gcc 1911
Val Ser His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala
    475 480 485
att ggc gag agc ttc atc atg aag cgt gga gac agc ttc ctc gat ggg 1959
Ile Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly
490 495 500 505
acc cgg tgt atg cca agt ggc ccc cgg gag gac ggg acc ctg agc ctg 2007
Thr Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu
                510 515 520
tgt gtg tcg ggc agc tgc agg aca ttt ggc tgt gat ggt agg atg gac 2055
Cys Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp
            525 530 535
tcc cag cag gta tgg gac agg tgc cag gtg tgt ggt ggg gac aac agc 2103
Ser Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser
        540 545 550
acg tgc agc cca cgg aag ggc tct ttc aca gct ggc aga gcg aga gaa 2151
Thr Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu
    555 560 565
tat gtc acg ttt ctg aca gtt acc ccc aac ctg acc agt gtc tac att 2199
Tyr Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile
570 575 580 585
gcc aac cac agg cct ctc ttc aca cac ttg gcg gtg agg atc gga ggg 2247
Ala Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly
                590 595 600
cgc tat gtc gtg gct ggg aag atg agc atc tcc cct aac acc acc tac 2295
Arg Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr
            605 610 615
ccc tcc ctc ctg gag gat ggt cgt gtc gag tac aga gtg gcc ctc acc 2343
Pro Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr
        620 625 630
gag gac cgg ctg ccc cgc ctg gag gag atc cgc atc tgg gga ccc ctc 2391
Glu Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu
    635 640 645
cag gaa gat gct gac atc cag gtt tac agg cgg tat ggc gag gag tat 2439
Gln Glu Asp Ala Asp Ile Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr
650 655 660 665
ggc aac ctc acc cgc cca gac atc acc ttc acc tac ttc cag cct aag 2487
Gly Asn Leu Thr Arg Pro Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys
                670 675 680
cca cgg cag gcc tgg gtg tgg gcc gct gtg cgt ggg ccc tgc tcg gtg 2535
Pro Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser Val
            685 690 695
agc tgt ggg gca ggg ctg cgc tgg gta aac tac agc tgc ctg gac cag 2583
Ser Cys Gly Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln
        700 705 710
gcc agg aag gag ttg gtg gag act gtc cag tgc caa ggg agc cag cag 2631
Ala Arg Lys Glu Leu Val Glu Thr Val Gln Cys Gln Gly Ser Gln Gln
    715 720 725
cca cca gcg tgg cca gag gcc tgc gtg ctc gaa ccc tgc cct ccc tac 2679
Pro Pro Ala Trp Pro Glu Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr
730 735 740 745
tgg gcg gtg gga gac ttc ggc cca tgc agc gcc tcc tgt ggg ggc ggc 2727
Trp Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly
                750 755 760
ctg cgg gag cgg cca gtg cgc tgc gtg gag gcc cag ggc agc ctc ctg 2775
Leu Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu
            765 770 775
aag aca ttg ccc cca gcc cgg tgc aga gca ggg gcc cag cag cca gct 2823
Lys Thr Leu Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala
        780 785 790
gtg gcg ctg gaa acc tgc aac ccc cag ccc tgc cct gcc agg tgg gag 2871
Val Ala Leu Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu
    795 800 805
gtg tca gag ccc agc tca tgc aca tca gct ggt gga gca ggc ctg gcc 2919
Val Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala
810 815 820 825
ttg gag aac gag acc tgt gtg cca ggg gca gat ggc ctg gag gct cca 2967
Leu Glu Asn Glu Thr Cys Val Pro Gly Ala Asp Gly Leu Glu Ala Pro
                830 835 840
ggt act gag ggg cct ggc tcc gta gat gag aag ctg cct gcc cct gag 3015
Val Thr Glu Gly Pro Gly Ser Val Asp Glu Lys Leu Pro Ala Pro Glu
            845 850 855
ccc tgt gtc ggg atg tca tgt cct cca ggc tgg ggc cat ctg gat gcc 3063
Pro Cys Val Gly Met Ser Cys Pro Pro Gly Trp Gly His Leu Asp Ala
        860 865 870
acc tct gca ggg gag aag gct ccc tcc cca tgg ggc agc atc agg acg 3111
Thr Ser Ala Gly Glu Lys Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr
    875 880 885
ggg gct caa gct gca cac gtg tgg acc cct gcg gca ggg tcg tgc tcc 3159
Gly Ala Gln Ala Ala His Val Trp Thr Pro Ala Ala Gly Ser Cys Ser
890 895 900 905
gtc tcc tgc ggg cga ggt ctg atg gag ctg cgt ttc ctg tgc atg gac 3207
Val Ser Cys Gly Arg Gly Leu Met Glu Leu Arg Phe Leu Cys Met Asp
                910 915 920
tct gcc ctc agg gtg cct gtc cag gaa gag ctg tgt ggc ctg gca agc 3255
Ser Ala Leu Arg Val Pro Val Gln Glu Glu Leu Cys Gly Leu Ala Ser
            925 930 935
aag cct ggg agc cgg cgg gag gtc tgc cag gct gtc ccg tgc cct gct 3303
Lys Pro Gly Ser Arg Arg Glu Val Cys Gln Ala Val Pro Cys Pro Ala
        940 945 950
cgg tgg cag tac aag ctg gcg gcc tgc agc gtg agc tgt ggg aga ggg 3351
Arg Trp Gln Tyr Lys Leu Ala Ala Cys Ser Val Ser Cys Gly Arg Gly
    955 960 965
gtc gtg cgg agg atc ctg tat tgt gcc cgg gcc cat ggg gag gac gat 3399
Val Val Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp Asp
970 975 980 985
ggt gag gag atc ctg ttg gac acc cag tgc cag ggg ctg cct cgc ccg 3447
Gly Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro
                990 995 1000
gaa ccc cag gag gcc tgc agc ctg gag ccc tgc cca cct agg tgg 3492
Glu Pro Gln Glu Ala Cys Ser Leu Glu Pro Cys Pro Pro Arg Trp
            1005 1010 1015
aaa gtc atg tcc ctt ggc cca tgt tcg gcc agc tgt ggc ctt ggc 3537
Lys Val Met Ser Leu Gly Pro Cys Ser Ala Ser Cys Gly Leu Gly
            1020 1025 1030
act gct aga cgc tcg gtg gcc tgt gtg cag ctc gac caa ggc cag 3582
Thr Ala Arg Arg Ser Val Ala Cys Val Gln Leu Asp Gln Gly Gln
            1035 1040 1045
gac gtg gag gtg gac gag gcg gcc tgt gcg gcg ctg gtg cgg ccc 3627
Asp Val Glu Val Asp Glu Ala Ala Cys Ala Ala Leu Val Arg Pro
            1050 1055 1060
gag gcc agt gtc ccc tgt ctc att gcc gac tgc acc tac cgc tgg 3672
Glu Ala Ser Val Pro Cys Leu Ile Ala Asp Cys Thr Tyr Arg Trp
            1065 1070 1075
cat gtt ggc acc tgg atg gag tgc tct gtt tcc tgt ggg gat ggc 3717
His Val Gly Thr Trp Met Glu Cys Ser Val Ser Cys Gly Asp Gly
            1080 1085 1090
atc cag cgc cgg cgt gac acc tgc ctc gga ccc cag gcc cag gcg 3762
Ile Gln Arg Arg Arg Asp Thr Cys Leu Gly Pro Gln Ala Gln Ala
            1095 1100 1105
cct gtg cca gct gat ttc tgc cag cac ttg ccc aag ccg gtg act 3807
Pro Val Pro Ala Asp Phe Cys Gln His Leu Pro Lys Pro Val Thr
            1110 1115 1120
ggt cgt ggc tgc tgg gct ggg ccc tgt gtg gga cag ggt acg ccc 3852
Val Arg Gly Cys Trp Ala Gly Pro Cys Val Gly Gln Gly Thr Pro
            1125 1130 1135
agc ctg gtg ccc cac gaa gaa gcc gct gct cca gga cgg acc aca 3897
Ser Leu Val Pro His Glu Glu Ala Ala Ala Pro Gly Arg Thr Thr
            1140 1145 1150
gcc acc cct gct ggt gcc tcc ctg gag tgg tcc cag gcc cgg ggc 3942
Ala Thr Pro Ala Gly Ala Ser Leu Glu Trp Ser Gln Ala Arg Gly
            1155 1160 1165
ctg ctc ttc tcc ccg gct ccc cag cct cgg cgg ctc ctg ccc ggg 3987
Leu Leu Phe Ser Pro Ala Pro Gln Pro Arg Arg Leu Leu Pro Gly
            1170 1175 1180
ccc cag gaa aac tca gtg cag tcc agt gcc tgt ggc agg cag cac 4032
Pro Gln Glu Asn Ser Val Gln Ser Ser Ala Cys Gly Arg Gln His
            1185 1190 1195
ctt gag cca aca gga acc att gac atg cga ggc cca ggg cag gca 4077
Leu Glu Pro Thr Gly Thr Ile Asp Met Arg Gly Pro Gly Gln Ala
            1200 1205 1210
gac tgt gca gtg gcc att ggg cgg ccc ctc ggg gag gtg gtg acc 4122
Asp Cys Ala Val Ala Ile Gly Arg Pro Leu Gly Glu Val Val Thr
            1215 1220 1225
ctc cgc gtc ctt gag agt tct ctc aac tgc agt gcg ggg gac atg 4167
Leu Arg Val Leu Glu Ser Ser Leu Asn Cys Ser Ala Gly Asp Met
            1230 1235 1240
ttg ctg ctt tgg ggc cgg ctc acc tgg agg aag atg tgc agg aag 4212
Leu Leu Leu Trp Gly Arg Leu Thr Trp Arg Lys Met Cys Arg Lys
            1245 1250 1255
ctg ttg gac atg act ttc agc tcc aag acc aac acg ctg gtg gtg 4257
Leu Leu Asp Met Thr Phe Ser Ser Lys Thr Asn Thr Leu Val Val
            1260 1265 1270
agg cag cgc tgc ggg cgg cca gga ggt ggg gtg ctg ctg cgg tat 4302
Arg Gln Arg Cys Gly Arg Pro Gly Gly Gly Val Leu Leu Arg Tyr
            1275 1280 1285
ggg agc cag ctt gct cct gaa acc ttc tac aga gaa tgt gac atg 4347
Gly Ser Gln Leu Ala Pro Glu Thr Phe Tyr Arg Glu Cys Asp Met
            1290 1295 1300
cag ctc ttt ggg ccc tgg ggt gaa atc gtg agc ccc tcg ctg agt 4392
Gln Leu Phe Gly Pro Trp Gly Glu Ile Val Ser Pro Ser Leu Ser
            1305 1310 1315
cca gcc acg agt aat gca ggg ggc tgc cgg ctc ttc att aat gtg 4437
Pro Ala Thr Ser Asn Ala Gly Gly Cys Arg Leu Phe Ile Asn Val
            1320 1325 1330
gct ccg cac gca cgg att gcc atc cat gcc ctg gcc acc aac atg 4482
Ala Pro His Ala Arg Ile Ala Ile His Ala Leu Ala Thr Asn Met
            1335 1340 1345
ggc gct ggg acc gag gga gcc aat gcc agc tac atc ttg atc cgg 4527
Gly Ala Gly Thr Glu Gly Ala Asn Ala Ser Tyr Ile Leu Ile Arg
            1350 1355 1360
gac acc cac agc ttg agg acc aca gcg ttc cat ggg cag cag gtg 4572
Asp Thr His Ser Leu Arg Thr Thr Ala Phe His Gly Gln Gln Val
            1365 1370 1375
ctc tac tgg gag tca gag agc agc cag gct gag atg gag ttc agc 4617
Leu Tyr Trp Glu Ser Glu Ser Ser Gln Ala Glu Met Glu Phe Ser
            1380 1385 1390
gag ggc ttc ctg aag gct cag gcc agc ctg cgg ggc cag tac tgg 4662
Glu Gly Phe Leu Lys Ala Gln Ala Ser Leu Arg Gly Gln Tyr Trp
            1395 1400 1405
acc ctc caa tca tgg gta ccg gag atg cag gac cct cag tcc tgg 4707
Thr Leu Gln Ser Trp Val Pro Glu Met Gln Asp Pro Gln Ser Trp
            1410 1415 1420
aag gga aag gaa gga acc tga gggtcattga acatttgttc cgtgtctggc 4758
Lys Gly Lys Glu Gly Thr
            1425
cagccctgga gggttgaccc ctggtctcag tgctttccaa ttcgaacttt ttccaatctt 4818
aggtatctac tttagagtct tctccaatgt ccaaaaggct agggggttgg aggtggggac 4878
tctggaaaag cagcccccat ttcctcgggt accaataaat aaaacatgca ggctg 4933


<210> 4
<211> 1427
<212> PRT
<213> Homo sapiens

<400> 4

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala
1 5 10 15
Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His
            20 25 30
Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser
        35 40 45
Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly
    50 55 60
Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu
65 70 75 80
His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His
                85 90 95
Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala
            100 105 110
Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu
        115 120 125
Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr
    130 135 140
Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr
145 150 155 160
Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu
                165 170 175
Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val
            180 185 190
Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys
        195 200 205
Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His
    210 215 220
Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser
225 230 235 240
Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro
                245 250 255
Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser
            260 265 270
Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro
        275 280 285
Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr
    290 295 300
Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val
305 310 315 320
Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser
                325 330 335
Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val
            340 345 350
Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys
        355 360 365
Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His
    370 375 380
Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys
385 390 395 400
Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro
                405 410 415
Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met
            420 425 430
Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln
        435 440 445
Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly
    450 455 460
Ala Ser Phe Tyr His Trp Gly Ala Ala Val Ser His Ser Gln Gly Asp
465 470 475 480
Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met
                485 490 495
Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly
            500 505 510
Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg
        515 520 525
Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg
    530 535 540
Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly
545 550 555 560
Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val
                565 570 575
Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe
            580 585 590
Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys
        595 600 605
Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly
    610 615 620
Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu
625 630 635 640
Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln
                645 650 655
Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp
            660 665 670
Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp
        675 680 685
Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg
    690 695 700
Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu
705 710 715 720
Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala
                725 730 735
Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly
            740 745 750
Pro Cys Ser Ala Ser Cys Gly Gly Gly Gly Leu Arg Glu Arg Pro Val Arg
        755 760 765
Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg
    770 775 780
Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn
785 790 795 800
Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys
                805 810 815
Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val
            820 825 830
Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser
        835 840 845
Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys
    850 855 860
Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala
865 870 875 880
Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val
                885 890 895
Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu
            900 905 910
Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val
        915 920 925
Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu
    930 935 940
Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala
945 950 955 960
Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr
                965 970 975
Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp
            980 985 990
Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln Glu Ala Cys Ser
        995 1000 1005
Leu Glu Pro Cys Pro Pro Arg Trp Lys Val Met Ser Leu Gly Pro
    1010 1015 1020
Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg Arg Ser Val Ala
    1025 1030 1035
Cys Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val Asp Glu Ala
    1040 1045 1050
Ala Cys Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro Cys Leu
    1055 1060 1065
Ile Ala Asp Cys Thr Tyr Arg Trp His Val Gly Thr Trp Met Glu
    1070 1075 1080
Cys Ser Val Ser Cys Gly Asp Gly Ile Gln Arg Arg Arg Asp Thr
    1085 1090 1095
Cys Leu Gly Pro Gln Ala Gln Ala Pro Val Pro Ala Asp Phe Cys
    1100 1105 1110
Gln His Leu Pro Lys Pro Val Thr Val Arg Gly Cys Trp Ala Gly
    1115 1120 1125
Pro Cys Val Gly Gln Gly Thr Pro Ser Leu Val Pro His Glu Glu
    1130 1135 1140
Ala Ala Ala Pro Gly Arg Thr Thr Ala Thr Pro Ala Gly Ala Ser
    1145 1150 1155
Leu Glu Trp Ser Gln Ala Arg Gly Leu Leu Phe Ser Pro Ala Pro
    1160 1165 1170
Gln Pro Arg Arg Leu Leu Pro Gly Pro Gln Glu Asn Ser Val Gln
    1175 1180 1185
Ser Ser Ala Cys Gly Arg Gln His Leu Glu Pro Thr Gly Thr Ile
    1190 1195 1200
Asp Met Arg Gly Pro Gly Gln Ala Asp Cys Ala Val Ala Ile Gly
    1205 1210 1215
Arg Pro Leu Gly Glu Val Val Thr Leu Arg Val Leu Glu Ser Ser
    1220 1225 1230
Leu Asn Cys Ser Ala Gly Asp Met Leu Leu Leu Trp Gly Arg Leu
    1235 1240 1245
Thr Trp Arg Lys Met Cys Arg Lys Leu Leu Asp Met Thr Phe Ser
    1250 1255 1260
Ser Lys Thr Asn Thr Leu Val Val Arg Gln Arg Cys Gly Arg Pro
    1265 1270 1275
Gly Gly Gly Val Leu Leu Arg Tyr Gly Ser Gln Leu Ala Pro Glu
    1280 1285 1290
Thr Phe Tyr Arg Glu Cys Asp Met Gln Leu Phe Gly Pro Trp Gly
    1295 1300 1305
Glu Ile Val Ser Pro Ser Leu Ser Pro Ala Thr Ser Asn Ala Gly
    1310 1315 1320
Gly Cys Arg Leu Phe Ile Asn Val Ala Pro His Ala Arg Ile Ala
    1325 1330 1335
Ile His Ala Leu Ala Thr Asn Met Gly Ala Gly Thr Glu Gly Ala
    1340 1345 1350
Asn Ala Ser Tyr Ile Leu Ile Arg Asp Thr His Ser Leu Arg Thr
    1355 1360 1365
Thr Ala Phe His Gly Gln Gln Val Leu Tyr Trp Glu Ser Glu Ser
    1370 1375 1380
Ser Gln Ala Glu Met Glu Phe Ser Glu Gly Phe Leu Lys Ala Gln
    1385 1390 1395
Ala Ser Leu Arg Gly Gln Tyr Trp Thr Leu Gln Ser Trp Val Pro
    1400 1405 1410
Glu Met Gln Asp Pro Gln Ser Trp Lys Gly Lys Glu Gly Thr
    1415 1420 1425


<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: an artificially
      synthesized primer sequence

<400> 5
tgaggccaca cccacatctt g 21


<210> 6
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: an artificially
      synthesized primer sequence

<400> 6
atgccagagc ctgaaccact t 21