JP2003289781A - Vaporizing apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a vaporizing apparatus stably vaporizing a volatile chemical over a somewhat long period. <P>SOLUTION: The vaporizing apparatus is composed of a chemical composition-containing carrier and a fan. The chemical composition-containing carrier is arranged in an air stream produced with the fan. The chemical composition-containing carrier is obtained by mixing the volatile chemical with an embedding material so as to provide 0.1-50 ratio of the embedding material/ volatile chemical expressed in terms of weight ratio and supporting the resultant mixture on a granular carrier having 1-15 mm grain diameter. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a volatilization device comprising a carrier containing a pharmaceutical composition and a fan.

[0002]

2. Description of the Related Art When a volatile insecticide is volatilized in a room, a fan is used to promote the volatilization because the vapor pressure of the chemical is low. It is disclosed in Japanese Patent Laid-Open No. 7-111850.

In these techniques, a carrier is impregnated with the above-mentioned drug, and a honeycomb structure is formed so that the amount of the drug volatilized is not biased, and the hole diameter of the structure and the depth of the carrier are defined.

[0004]

However, in order to volatilize the drug over a long period of time, it is necessary to lengthen the depth of the holding body or increase the structure thereof, and the fan becomes larger accordingly. The device becomes large.

On the other hand, the one using a granular drug impregnated body is disclosed in Japanese Patent Application Laid-Open No. 10-191862. Since the chemical impregnated body is granular, the wind hits it uniformly,
It is possible to eliminate the variation in the amount of volatilization due to the part in the wind flow direction. Further, since it is granular, a large amount of the drug is carried, and the device can be made compact.

However, since this technique impregnates the chemicals, the chemicals move between the chemical-impregnated bodies when exposed to the air, and the initial volatilization rate is fast, and thereafter, the volatilization rate rapidly decreases with time. In addition, there is a risk of exudation of the drug, stickiness, and stains on the surroundings.

[0007] Therefore, an object of the present invention is to provide a volatilization device capable of stably volatilizing a volatile chemical for a certain period of time.

[0008]

The present invention comprises a pharmaceutical composition-containing carrier and a fan, and the pharmaceutical composition-containing carrier is placed in an air stream by the fan, and is used as the pharmaceutical composition-containing carrier. The problem described above is obtained by mixing the volatile drug and the embedding material in a weight ratio of embedding material / volatile agent = 0.1 to 50 and supporting them on a granular carrier having a particle size of 1 to 15 mm. Is solved.

By loading a predetermined granular carrier as the drug composition-containing carrier, even if the air volume is large, the air is uniformly blown to the carrier and the volatilization amount does not vary. In addition, by mixing the volatile drug and the embedding material in a prescribed ratio, the migration (unevenness) of the drug between the carriers due to the influence of the wind can be suppressed, so that the volatile drug can be stably volatile for a certain period of time. Can be made. Furthermore, the volatilization amount can be adjusted by the type and amount of the embedding material.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail below. As shown in FIG. 1, the volatilization apparatus according to the present invention comprises a drug composition-containing carrier 1 and a fan 2. The pharmaceutical composition-containing carrier 1 is arranged in the air flow generated by the fan 2, more preferably at a position that directly receives the wind generated by the fan 2. As a result, the volatile drug that has volatilized from the drug composition-containing carrier 1 diffuses into the space in which the volatilization device according to the present invention is placed.

The carrier 1 containing the drug composition is a granular carrier carrying a mixture of a volatile drug and an embedding material. The above-mentioned volatile chemical means a chemical that is volatile when heated at room temperature or heated. Examples of such volatile agents include aromatic agents, antibacterial / antifungal agents, insecticides, insecticides and the like. Since the effective concentration of these is effective for exerting the effect in the space depending on the type of the volatile drug, an appropriate volatile drug is selected according to the purpose. The vapor pressure of the above fragrance or antibacterial / antifungal agent is not particularly limited,
~ 1000 mmHg is preferred. If it is more than 1000 mmHg, the volatilization rate is too fast, and the volatilization rate may not be controlled stably. On the other hand, if it is less than 1 mmHg, a sufficient effective concentration may not be reached.

The vapor pressures of the above insecticides and insect repellents are
Although not particularly limited, it is 0.00001 for the same reason as above.
~ 0.01 mmHg is preferred.

Examples of the fragrance include natural fragrance and synthetic fragrance. Further, examples of the antibacterial / antifungal agent include allyl isothiocyanate, eugenol, hinokitiol and the like. Examples of the insect repellent include pyrethrin, allethrene, permethrin and the like. Examples of the insecticide include pyrethroid insect repellents such as empensulin, benfluthrin, and fenfluthrin.

The above-mentioned embedding material refers to a material which is solid at room temperature and can be kneaded with the volatile drug, and is appropriately selected depending on the kind of the volatile drug and the effective volatile amount. Examples of the embedding material include mineral wax represented by ozokerite, petroleum wax such as paraffin wax and microcrystalline wax, fatty acid and carnauba wax,
Natural wax such as rice wax, gum rosin, wood rosin, tall oil rosin, modified rosin and esterified products thereof, stearyl alcohol, stearic acid amide, benzoic acid, 2,6-di-t-butyl-4-methylphenol, etc. can give. These can be used alone or in combination of two or more.

The mixing ratio of the volatile drug and the embedding medium is selected according to the kind of the volatile drug of interest and the effective amount of volatilization, and the weight ratio of embedding medium / volatilizing drug = 0.1. -50 is preferable, and 0.5-3 is preferable. If it is less than 0.1, the amount of the embedding material is not sufficient. Therefore, if the air volume becomes large, the volatile drug moves between the carriers, and it becomes difficult to secure a constant volatile amount for a long period of time. On the other hand, when it exceeds 50,
The number of granular carriers increases more than necessary, and the volatilization device becomes large.

The above-mentioned granular carrier means a granular substance which can carry the mixture of the volatile drug and the embedding material and has a poor reactivity with the volatile drug. Examples of the material forming the carrier include natural polymers such as cellulose and chitosan and their derivatives, synthetic polymers such as polyvinyl alcohol, polyurethane, polyethylene and polypropylene, inorganic compounds such as silicates, silica gel, zeolite and alumina. Can be given.

The particle size of the granular carrier is 1 to 15 m.
m is good, and 2-8 mm is preferable. If it is less than 1 mm, a pressure loss occurs and the granular carrier is not uniformly blown. On the other hand, if it is larger than 15 mm, the wind passes through the granular carrier without hitting it.

As shown in FIG. 1, the drug composition-containing carrier 1 is arranged in the air flow of the fan 2. In the accommodating portion 3 of the drug composition-containing carrier 1, the drug composition-containing carrier 1 is arranged in the flow direction of the air flow. The opposing surfaces are preferably made of breathable member 4 that allows the airflow to pass through. The breathable member 4 may be a member having a mesh, a lattice, or the like.

[0019]

EXAMPLES The present invention will be described more specifically with reference to Examples and Comparative Examples below. First, the chemicals used in Examples and Comparative Examples and the test method are described below. <Chemicals> (1) Volatile chemicals and empensulin: manufactured by Sumitomo Chemical Co., Ltd. (hereinafter referred to as “E
Abbreviated as "PT". ) ・ Citrus fragrance: Takasago Fragrance Co., Ltd .; Citrus (2) embedding material ・ Stearyl alcohol: Kao Co., Ltd .; CALCOL 8
098 ・ Rosin ester: Arakawa Chemical Co., Ltd .; AA-G

(Examples 1 to 4 and Comparative Examples 1 and 2) Volatile drugs and embedding materials shown in Table 1 were mixed in the proportions shown in Table 1, and this was used as a granular carrier for cellulose beads (RENGO (stock). ): Viscopearl, particle size is shown in Table 1.) 4 g was loaded with 100 mg of EPT as a volatile drug to manufacture a drug composition-containing carrier. Carrier 40 containing this pharmaceutical composition
ml was filled in a cylindrical container (5 cmφ × 3 cm) made of a wallif (HS-24, manufactured by Nisseki Plast Co., Ltd.) having opposing air-permeable parts, and attached to the exhaust port of a sirocco fan. 1 month after the start of rotation (initial), 2 months after the start of rotation (middle period), and 3 months after the start of rotation (latter period), the amount of residual drug in the drug composition-containing carrier is analyzed by gas chromatography, Drug reduction amount is 1
It was the amount of volatilization for a month. The results are shown in Table 1.

[0021]

[Table 1]

Comparative Example 3 In Example 2, the weight of stearyl alcohol as the embedding material was 50 g (embedding material / volatile agent = 500). However, the carrier containing the pharmaceutical composition was 150 ml, and the entire amount could not be filled in the cylindrical container.

[0023]

EFFECTS OF THE INVENTION According to the present invention, as a carrier for containing a pharmaceutical composition, it is supported on a predetermined granular carrier, so that even if the air volume is large, the air is uniformly blown to the carrier and the volatilization amount does not vary.

Further, since the volatile drug and the embedding material are mixed at a predetermined ratio, the migration (bias) of the drug between the carriers can be suppressed by the influence of the wind, so that the volatile drug can be stabilized for a certain period of time. Can be volatilized. Furthermore, the volatilization amount can be adjusted by the type and amount of the embedding material.

[Brief description of drawings]

FIG. 1 is a schematic diagram showing an example of a volatilization device according to the present invention.

[Explanation of symbols]

1 Pharmaceutical composition-containing carrier 2 fans 3 storage 4 Breathable material

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Hidenao Saito             1-8-10 Jiyugaoka, Kanazu-cho, Sakai-gun, Fukui Prefecture             No. Rengo Co., Ltd. Fukui Research Center F term (reference) 2B121 AA11 AA20 CA02 CA15 CA43                       CA44 CA61 CC02 CC03 CC04                       EA01 FA05                 4C002 AA03 BB02 DD03 DD06 FF01                       HH06 KK01

Claims (2)

[Claims] 1. A drug composition-containing carrier and a fan, wherein the drug composition-containing carrier is placed in an air stream by the fan, and the volatile drug and the embedding material are used as the drug composition-containing carrier. And are mixed in a weight ratio of embedding material / volatile agent = 0.1 to 50 to obtain a particle size of 1 to 15
A volatilization device using what was supported on a granular carrier of mm. 2. The volatilization apparatus according to claim 1, wherein the volatile chemical is a fragrance, an antibacterial / antifungal agent, an insect repellent or an insecticide which has volatility at room temperature or when heated.