JP2003238329A - Skin external agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an excellent skin external agent improved with a peculiar bad smell of a basic amino acid. <P>SOLUTION: This skin external agent contains the basic amino acid and/or its salt and following components (A). (A): 1 kind or ≥2 kinds of components selected from a group consisting of cis-3-hexenol, linalol, β-naphthol methyl ether, nonyl lactone, deca lactone, undeca lactone, damascone, damascenone, cis-jasmone, dihydrojasmone, linalyl acetate, benzyl acetate, styrallyl acetate, cis-3-hexenyl acetate, benzyl propionate, lemon oil, lavender oil, rose oil, bergamot oil, ylang ylang oil, camomile oil, ceder wood oil, galbanum oil, elemi oil and/or plant extracts containing such components. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation having an improved unpleasant odor peculiar to basic amino acids.

[0002]

2. Description of the Related Art Basic amino acids have excellent physiological activity and can be used not only as a neutralizing agent but also as a base for fatty acid soaps used as emulsifiers and detergents, so that they are less irritating than strong bases. Since soap can be obtained, it has a high utility value as a base and is used as a highly versatile amino acid in external preparations for skin.

However, basic amino acids have a peculiar odor, and when an effective amount is added to a skin external preparation, the unpleasant odor gives unpleasant sensation during use, which is not satisfactory.

From the above problems, it has been attempted to use a water-soluble reducing agent in a detergent composition containing an anionic surfactant which forms a salt with a basic amino acid (JP-A 5-2).
Japanese Patent No. 55693) has also been proposed.

The raw materials generally used for external preparations for skin include
There is some kind of raw material odor, and although the basic amino acid odor has been a concern in the raw material state, it has not been a particular concern in products. However, improved refinement technology for raw materials, increased use of refined products especially for hypoallergenic cosmetics, and reduction of the amount of perfume blended into products for safety and usability. The unpleasant odor of basic amino acids has emerged again because of the tendency to do so.

The basic amino acid odor tends to increase with time in the compounded external preparation for skin. Furthermore, in the external preparation for skin that requires an emulsification reaction or a saponification reaction,
What was not so noticeable at the development stage is that the odor is strengthened at the actual production stage and becomes stronger over time. The main reason for this is that the manufacturing stage is exposed to heating for a longer period of time than the development stage, and it is difficult to manufacture these products without a heating process.

In such a case, generally, a fragrance is blended to add a certain amount so that the unpleasant odor is not noticeable, or the base is switched to a strong base such as potassium hydroxide. To be

[0008]

However, simply masking results in blending unnecessary concentrations,
In particular, when a basic amino acid is mixed with a skin external preparation intended for low irritation, which is said to be a recent cosmetic preparation for sensitive skin, there is a problem that masking is insufficient or safety cannot be dealt with. there were. In general, cosmetics for sensitive skin often do not use fragrances, and as a result, ingredients that cause unpleasant odors such as basic amino acids should be reduced in content as much as possible or not incorporated. Become.

Due to such a problem of unpleasant odor, the above-mentioned proposal of an attempt to suppress the change of the basic amino acid itself, and
Although attempts have been made to use basic amino acids with reduced unpleasant odors themselves due to improvements in manufacturing technology, attempts to specifically mask basic amino acid odors have not been studied. In particular, L-arginine is a widely used basic amino acid, but there is no example focusing on masking targeting only its odor.

[0010]

Means for Solving the Problems The present inventor has combined the basic amino acid and / or salt thereof with one or more selected from the following specific components to obtain a unique amino acid and / or salt thereof. You can selectively mask the unpleasant odor of
Moreover, the present inventors have found that the amount of the fragrance added can be suppressed to the necessary minimum, and that the fragrance can be used safely without any discomfort over time.

That is, the present invention provides a skin external preparation containing a basic amino acid and / or a salt thereof and the following component (A). As the component (A), cis-
3-hexenol (cis-3-Hexenol), linalool (Linalo
ol), β-Naphthol meth
yl ether), nonyl lactone, deca lactone, undeca lacton
e), Damascone, Damascenon
e), cis-Jasmone, Dihydro jasmone, Linalyl acetate
l acetate), benzyl acetate, styrylyl acetate, cis-3
-Hexenyl acetate, Benzyl propionate, Lemon oil, Lavender oil, Rose oil, Bergamot oil, Ylang-ylang oil, Chamomile oil, Cedarwood oil, Galvanum oil, Elemi oil and / Alternatively, one or more selected from the group consisting of plant extracts containing these components may be mentioned.

Examples of the basic amino acid used in the present invention include L-arginine, L-lysine, L-histidine and the like which are commonly used in external preparations for skin. Particularly versatile and useful as a base is L-arginine, which is particularly effective and preferable.

The concentration of the component (A) varies depending on the type of the component (A) used, the type and amount of the basic amino acid added to the skin external preparation, the form of the skin external preparation, and the like. The smell of basic amino acid starts to be noticeable, especially in a water dispersion system such as a lotion, and the amount of the basic amino acid added is 0.01.
I start to be worried about weight%. The amount of these components (A) is preferably 0.01 to 0.5, and more preferably 0.02 to 1 of the basic amino acid in a weight ratio.
It is 0.4. When it is less than 0.01, a sufficient masking effect cannot be obtained, and when it is 1 or more, unpleasant sensation is increased due to a single odor due to the component (A) or a mixed odor with a basic amino acid odor, and safety is improved. However, this is not preferable because it tends to cause problems.

These components (A) are effective when used alone or in combination. These components (A) can be classified into the following three groups (a), (b), and (c) based on their odor characteristics. When mixed use,
It is preferable to combine these characteristics.

The group (a) is a component that plays a basic role of odor, and includes nonyl lactone, decalactone, undeca lactone, damascon, damascenone, styralyl acetate,
Examples include cedar wood oil. By containing 30% by weight or more in the masking fragrance component, the sustainability becomes high, which is preferable.

Group (b) is a component that carries an intermediate odor, β
-Naphthol methyl ether, cis-jasmone, dihydrojasmone, benzyl propionate, lavender oil, rose oil, ylang-ylang oil, chamomile oil, galvanum oil, elemi oil and the like. By occupying 30 to 60% by weight of the masking fragrance component, the odors of the (a) group and the (c) group are connected to each other, which serves to give a unified feeling.

Group (c) is a component responsible for the first impression of odor,
Examples thereof include cis-3-hexenol, linalool, linalyl acetate, benzyl acetate, cis-3-hexenyl acetate, lemon oil and bergamot oil. It is preferably 30% by weight or less in the masking fragrance component.

The use of the external preparation for skin according to the present invention is as follows:
Although not particularly limited, for example, basic cosmetics such as cream, milky lotion, cleaning agent, lotion, beauty essence, shampoo, conditioner, treatment, hair lotion, hair treatment, hair cosmetics such as hair spray, foundation, mascara, Examples include emulsified makeup cosmetics such as eyeliners, as well as pharmaceuticals and quasi drugs.

The external preparation for skin according to the present invention may be blended with the following well-known components which are usually used, depending on the dosage form and application. Specifically, surfactants such as polyglycerin fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, and soybean lecithin, oil-based bases such as liquid paraffin, squalane, dimethylpolysiloxane, and methylphenylpolysiloxane,
Polyhydric alcohols such as glycerin and 1,3-butylene glycol, water-soluble polymers such as xanthan gum and carboxyvinyl polymers, pH regulators such as citric acid and lactic acid, anti-inflammatory agents such as allantoin and glycyrrhetinic acid derivatives, and other medicinal effects Ingredients, preservatives, antioxidants, ultraviolet absorbers, pigments, plant extracts, and other fragrances other than the above may be contained in any combination.

The external preparation for skin according to the present invention can be produced by a generally known method depending on its use and dosage form.

[0021]

EXAMPLES The present invention will be specifically described below with reference to examples.

[Examples 1 to 26 and Comparative Examples 1 and 2] Cream (1) Squalane 5.00 (wt%) Vaseline 10.00 Cetanol 2.50 Stearic acid 2.00 Salad beeswax 2.00 Lipophilic mono Glycerin stearate 1.00 (2) Purified water 100 adjustment 1,3-butylene glycol 5.00 potassium hydroxide 0.10 paraoxybenzoic acid ester 0.10 seawater dried product 1.00 L-arginine 0.35 citric acid pH Adjustment (pH 6.5) (3) Components shown in Tables 1 and 2 0.10 Production method: The oil phase components of (1) are mixed, heated and dissolved to 70 ° C. On the other hand, the water phase component of (2) is mixed and dissolved to 70 ° C.
Then, the oil phase component is added to the mixture and the mixture is emulsified with a homomixer. After cooling, (3) is added and mixed at 40 ° C.

[0023]

[Table 1]

[0024]

[Table 2]

Example 27 Lotion (1) Purified water 100 Preparation (wt%) 1,3-butylene glycol 10.00 Glycerin 3.00 Paraoxybenzoic acid ester 0.10 Seawater dried product 1.00 L-lysine 0.50 L-histidine 0.50 citric acid pH adjustment (pH 5.8) sodium lactate (50% by weight) 2.00 (2) polyglyceryl monolaurate 0.50 ethanol 4.00 undecalactone 0.08 cederwood oil 0 .05 Production method: After sequentially mixing and dissolving the components (1), the components (2) previously mixed and dissolved are added and homogenized.

[Example 28] Beauty essence (1) Purified water 100 Preparation (% by weight) 1,3-butylene glycol 15.00 Carboxyvinyl polymer 0.10 Paraoxybenzoic acid ester 0.10 L-Arginine 0.35 Quen Acid pH adjustment (pH 6.8) (2) Ethanol 5.00 Linalool 0.10 Sucrose fatty acid ester 0.50 Manufacturing method: After (1) components are sequentially mixed and dissolved, (2) components that have been mixed and dissolved in advance are added, Homogenize.

Example 29 Liquid Soap (1) Lauric Acid 1.20 (wt%) Myristic Acid 4.80 Isostearic Acid 0.60 Glycerin 10.00 Sorbitol 10.00 (2) Purified Water 63.10 L- Arginine 9.00 (3) 1,3-butylene glycol 1.00 Paraoxybenzoic acid ester 0.05 Benzyl propionate 0.10 Chamomile oil 0.15 Production method: The components of (1) are mixed and dissolved by heating, 70 ℃. On the other hand, the water phase component (2) is mixed and dissolved and heated to 70 ° C., and the oil phase component is gradually added to this to mix and homogenize, and completely saponify. After cooling, (3) is added and mixed at 50 ° C.

Example 30 Shampoo Composition (1) Purified Water 68.96 (wt%) (2) Coconut Oil Fatty Acid L-Arginine Soap 25.0 Palm Oil Fatty Acid Diethanolamide 4.0 Lauryldimethylbenzylammonium Chloride 1 0.0 Sodium chloride 1.0 Lemon oil 0.01 Lavender (50% by volume ethanol extract) 0.01 Chamomile (50% by volume ethanol extract) 0.01 Elemi oil 0.01 Manufacturing method: (1) component ( The components of 2) are sequentially mixed and made uniform.

The unpleasant odor was evaluated using Examples 1 to 26, Comparative Examples 1 and 2. At the same time, all the ingredients shown in Table 1 were replaced with purified water to prepare a cream, which was evaluated as a blank.

The creams of Examples 1 to 26, Comparative Example 1 and Comparative Example 2 and the blank were stored in a constant temperature bath at 50 ° C. for 1 month, then returned to room temperature and evaluated for unpleasant odor. As an evaluation method, 20 panelists with a strong sense of smell were selected and evaluated by a sensory test. The evaluation criteria are five levels: "1: not at all,""2: not at all,""3: slightly worried,""4:worried,""5:worried," Tables 3 and 4 according to the number of panelists who obtained each evaluation
The results are shown in.

[0031]

[Table 3]

[0032]

[Table 4]

In Tables 3 and 4, a high effect of improving the unpleasant odor was recognized in the groups used in Examples. On the other hand, in the group using the comparative example, a complete improvement was observed only in 20 to 25% of panelists.

[0034]

As described above in detail, according to the present invention, it is possible to provide a skin external preparation with an improved unpleasant odor characteristic of basic amino acids.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/075 A61K 7/075 7/50 7/50 C11D 3/20 C11D 3/20 3/33 3 / 33 3/382 3/382 F-term (reference) 4C083 AA082 AA111 AA121 AA122 AA162 AB032 AB332 AC012 AC022 AC061 AC062 AC072 AC102 AC122 AC132 AC171 AC172 AC242 AC262 AC302 AC341 AC342 AC352 AC422 AC482 AC51 AC421 ACBB1 AD8422 AD042 AD8422 AD042 AD042 AD042 CC04 CC05 CC23 CC25 CC38 DD22 DD23 DD27 DD31 EE03 EE06 EE11 EE18 EE21 FF05 4H003 AB03 DA02 EB02 EB04 EB05 EB06 EB09 EB13 EB43 ED02 FA02

Claims (3)

[Claims] 1. A basic amino acid and / or a salt thereof,
A skin external preparation containing the following component (A). (A); cis-3-hexenol, linalool,
β-naphthol methyl ether, nonyl lactone, decalactone, undecalactone, damascon, damacenone, cis-jasmon, dihydrojasmon, linalyl acetate, benzyl acetate, styrylyl acetate, cis-3-hexenyl acetate, benzyl propionate, lemon oil , One or more selected from the group consisting of lavender oil, rose oil, bergamot oil, ylang-ylang oil, chamomile oil, cedarwood oil, galvanum oil, elemi oil and / or plant extracts containing these components Ingredients. 2. The basic amino acid is L-arginine, L-
The external preparation for skin according to claim 1, which is one kind or two or more kinds selected from lysine and L-histidine. 3. The amount of the basic amino acid and / or salt thereof and the component (A) is 0.01 to 0.5 by weight ratio of the component (A) with respect to 1 part of the basic amino acid and / or salt thereof. The external preparation for skin according to claim 1 or 2, which is characterized by being present.