JP2003207443A - Photometric apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an optimum signal intensity level even if light reception/ transmission conditions such as a light transmission section, a light reception section, or an area between light transmitted/received light differs in a photometric apparatus having a plurality of light transmission points and a plurality of light reception points. <P>SOLUTION: The photometric apparatus that applies light to a specimen and measures light that is discharged to the outside after light is transmitted or reflected in the inside of the specimen comprises a light transmission/reception means 2 having a plurality of light transmission sections for applying light having one or a plurality of wavelengths to the specimen and a plurality of light reception sections for receiving light that is radiated from the specimen, a plurality of amplifiers 4 for amplifying each of measured signals that are measured by each light reception section, and/or a plurality of attenuation means 8 for attenuating each light intensity that is applied to each light reception section. During measurement, each amplification factor in the amplification means and/or each attenuation rate in the attenuation means are changed. An optimum signal strength level is obtained by changing each amplification factor in the amplification means and each attenuation rate in the attenuation means according to light transmission/reception conditions that change during measurement. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an optical measuring device,
The present invention relates to an apparatus for measuring the internal distribution of scattering absorption of a living body by light.

[0002]

2. Description of the Related Art The internal distribution of scattering absorption of a subject is measured by light, and the change over time of biological components is measured by this light measurement to diagnose normal / abnormal tissue, or blood flow in various parts of the brain over time. Optical measurement devices used in the medical field have been proposed, such as measuring changes in oxygen supply and changes in oxygen supply to perform brain function measurement and cardiovascular system diagnosis.

As such an optical measuring device, a multi-channel optical measuring device having a plurality of light-transmitting portions and light-receiving portions and a plurality of channels is known, and products such as a multi-channel oxygen monitor are also commercially available. There is.

In such a multi-channel optical measuring device, the received light is detected by a detector as an electric signal. FIG. 10 shows a configuration example of a detector included in a conventional multi-channel optical measurement device.

The detector 100 is a photomultiplier tube (photomultiplier) 10 as a means for converting light from an object into an electric signal.
1 is used. The photomultiplier tube 101 includes a photocathode 101a that emits photoelectrons according to received light, an amplifier 101b that increases the number of photoelectrons, and an amplifier 101.
A negative voltage unit 101c for supplying a negative voltage applied to b is provided, and this amplifier 101b has a detection signal multiplication function. The measurement signal (current value) detected by the photomultiplier tube 101 is converted into a voltage by the preamplifier 102, and then input to the A / D converter 105 via the amplifier (voltage amplification circuit) 103 and the integration circuit 104. The detection signal converted into the digital signal is output to the data acquisition unit 120. The data acquisition unit 120 records and displays the detection signal. The light detection control unit 110 controls the detection unit 100. Further, when measuring different irradiation wavelengths or different irradiation places, the signals separated in wavelength and place are detected by performing lighting and non-lighting in time series.

[0006]

In an optical biometric device such as a multi-channel oxygen monitor, the light transmitting / receiving means (one end of the light transmitting fiber and the light receiving fiber) is brought into close contact with the measurement site of the object to be transmitted therethrough. The light intensity, the reflected light intensity, or its intensity change is measured. In this measurement,
In addition to individual differences of the subject such as a person who easily transmits light or a person who does not easily transmit light, measurement sites such as the head and limbs of the same subject, as well as between the ends of the light transmitting fiber and the light receiving fiber, for example, 2
The obtained light intensity varies greatly depending on various measurement conditions such as the distance between transmission and reception of whether the distance is 3 cm or 3 cm, the installation state such as whether the hair is large or small, and the irradiation wavelength.

Therefore, in the detector shown in FIG. 10, the light intensity is usually confirmed in the preliminary measurement before the main measurement, and the signal is amplified in accordance with the obtained intensity to acquire data. . By the way, a multi-channel oxygen monitor having a plurality of light-transmitting points and a plurality of light-receiving points is characterized in that measurement is performed by combining these plurality of light-receiving points. For example, as shown in FIG. At the point (detection point 1), light from a plurality of light transmitting points (light transmitting section A, light transmitting section B) is separated and detected.

When the subject is a living body, the intensity of light propagating through the inside of the living body and being re-emitted is determined by the light transmitting / receiving distance (light transmitting point A and light receiving portion 1).
Or the distance between the light-sending point B and the light-receiving portion 1) is exponentially attenuated. For example, the distance between transmitting and receiving light is 1 cm
When it is spread, the light intensity is attenuated to about 1/10. Therefore, as shown in FIG. 11, when the distance between the light transmitting point B and the light receiving portion 1 is longer than the distance between the light transmitting point A and the light receiving portion 1, a combination of the light transmitting point B and the light receiving portion 1 is obtained. The light intensity is considerably weaker than the light intensity obtained at the light transmitting point A and the light receiving portion 1.

Further, as described above, the detected light intensity depends not only on the above-mentioned transmission / reception distance but also on the installation condition of the fiber and the irradiation wavelength, so the actual difference in light intensity depends on the transmission / reception point. Depending on the combination, it can be quite large.

Therefore, in the conventional optical measuring device, since signal amplification is performed at a constant signal amplification rate in the light receiving section, (1) a combination having a strong detected light intensity (for example, the light transmitting point A and the light receiving section 1 in FIG. 10). If the signal amplification factor is set in accordance with the combination (1), the amplification signal obtained by the combination with the weak detected light intensity (for example, the combination of the light transmitting point B and the light receiving unit 1 in FIG. 11) becomes weak, and the amplifier in FIG. 10
3, it becomes extremely weak against noise superimposed on the integrator 104 and the A / D converter 105, and the S / N ratio decreases. (2) When the signal amplification factor is set according to the combination with the weak detected light intensity, the amplified signal obtained by the combination with the strong detected light intensity is saturated beyond the dynamic range of the light receiving section, which makes accurate measurement difficult. There is a problem in the signal strength level of the detection signal.

Therefore, the present invention solves the above-mentioned conventional problems, and in an optical measuring device having a plurality of light-transmitting points and a plurality of light-receiving points, the light-transmitting section, the light-receiving section, or the light-transmitting / receiving section such as between the light-receiving section The purpose is to obtain an optimum signal strength level even under different conditions.

[0012]

According to the present invention, amplification of a measurement signal measured by a plurality of light receiving sections and attenuation of light intensity incident on each light receiving section are combined in a light transmitting section and a light receiving section. The optimum signal intensity level can be obtained by changing the light transmission / reception conditions such as the light transmission unit, the light reception unit, or the light transmission / reception conditions. It should be noted that the amplification of the measurement signal and the attenuation of the light intensity incident on each light receiving unit may be performed either alone, or both may be combined.

The optical measuring device of the present invention is an optical measuring device for irradiating a subject with light and measuring the light emitted to the outside after being transmitted and / or reflected in the subject. Light-transmitting / receiving means having a plurality of light-transmitting portions for irradiating light of one or a plurality of wavelengths and a plurality of light-receiving portions for receiving light emitted from the subject, and measuring signals measured by the respective light-receiving portions, respectively. A plurality of amplifying means for amplifying and / or a plurality of attenuating means for respectively attenuating the light intensity incident on each light receiving part are provided, and each amplification factor of the amplifying means and / or each attenuation of the attenuating means during measurement. Change the rate. An optimum signal intensity level is obtained by changing each amplification factor of the amplification means and each attenuation factor of the attenuation means according to the transmission / reception conditions that change during measurement.

Further, as one mode in which each amplification factor of the amplification means and / or each attenuation factor of the attenuation means is changed during measurement,
A control unit for controlling the light transmission / reception of the light transmission / reception unit and the amplification factor of the amplification unit or the attenuation factor of the attenuation unit is provided, and the control unit is a combination of a light transmission unit and a light reception unit for performing irradiation wavelength and / or light transmission / reception. And a control table that defines the order, an amplification factor table that defines the amplification factor corresponding to the combination set in the control table, and / or an attenuation factor table that defines the attenuation factor corresponding to the combination set in the control table. Equipped with.

The control means performs light transmission / reception control based on the irradiation wavelength and / or the combination and order of the light transmission part and the light reception part defined in the control table, and in synchronization with the control of the control table, the amplification factor table. The control for setting the amplification factor defined in 1) to each amplification means or the control for setting the attenuation factor defined in the attenuation rate table in each attenuation factor means is performed. Also, both of them can be controlled.

In this aspect, the amplification factor table and / or the attenuation factor table corresponds to the combination and order of the light transmitting unit and the light receiving unit defined by the control table, and the set combination of the light transmitting unit and the light receiving unit and It is set in advance according to the order, and the amplification factor and the attenuation factor are changed according to the combination of the light transmitting unit and the light receiving unit that changes during measurement.

Also, during measurement, each amplification factor of the amplification means and / or
Or, as another aspect of changing each damping rate of the damping means,
Light transmission / reception of the light transmission / reception means, and amplification factor of the amplification means and /
Or a control means for controlling the damping rate of the damping means,
The control means includes a control table that defines the combination and order of the light-transmitting part and the light-receiving part that perform irradiation wavelength and / or light transmission / reception,
An amplification factor table that defines at least one combination of amplification factors of each amplification unit and / or an attenuation factor table that defines at least one combination of attenuation factors of each of the attenuation units. The amplification factor table and the attenuation factor table are not limited to the correspondence with the combinations set in the control table.

The control means includes the irradiation wavelength defined in the control table and / or the combination and order of the light-transmitting part and the light-receiving part, and the attenuation factor defined in the amplification factor table and / or the attenuation factor defined in the attenuation factor table. A combination of a ratio and a combination of the control table and the amplification factor table and / or a combination of the control table and the attenuation ratio table is used to perform transmission / reception control, and also to set the amplification factor and / or the attenuation factor. .

In this other aspect, an amplification factor table and / or
Alternatively, the attenuation rate table is set independently of the combination and order of the light transmitting unit and the light receiving unit defined by the control table,
By combining the control table with the amplification factor table and / or the attenuation factor table, the amplification factor and the attenuation factor are changed according to the combination of the light transmitting unit and the light receiving unit which changes during measurement. Switching of each combination of the control table and the amplification factor table and / or the attenuation factor table is performed by
It can be done synchronously or asynchronously.

In each of the above aspects, the control table includes a light transmitting table and a light receiving table, and the amplification factor of the detecting section is changed by using the amplification factor table for each combination of the light transmitting and receiving points in association with the control table. By using the amplification factor table, the amplification factor of the amplification unit provided in the light receiving unit is changed in association with the light transmitting / receiving state. For example, when the detected light intensities of the light transmitting point B and the light receiving portion 1 are 1/100 of those of the light transmitting point A and the light receiving portion 1, when the amplification factor of the light receiving portion 1 is irradiated at the light transmitting point A, By changing the measurement data or the light intensity by 100 times when the light is emitted at the light transmitting point B, the signals of both combinations are measured with good S / N.

The measurement signals continuously obtained in time series by each of the above means can be recorded in the recording means or displayed on the display means, or transmitted to another device by the communication means. You can

[0022]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described in detail below with reference to the drawings. FIG. 1 shows a schematic configuration diagram for explaining an example of the configuration of the optical measurement device of the present invention. The configuration example shown in FIG. 1 is an example including an amplification factor table.

In FIG. 1, the optical measuring device 1 is a subject 1
A light transmitting unit 22a for irradiating light to 0, a light receiving unit 22b for receiving light from the subject 10, a light transmitting / receiving unit 22 including a measurement probe, and a light emitting unit 21 for transmitting light to the light transmitting unit 22a,
Photodetector 23 for detecting the light received by the light receiver 22b
And an amplification means 4 for amplifying the signal detected by the photodetection section 23.
And a control unit 3 for controlling the light emitting unit 21, the light detecting unit 23, and the amplifying unit 4, and further, a signal acquiring unit 5, a recording unit 6, and a displaying unit 7 for acquiring the measurement signal amplified by the amplifying unit 4. Equipped with.

The control section 3 controls the light emitting section 21 to control the light transmission from the light transmitting section 22a, the light receiving control of the light detecting section 23, and the setting of the amplification factor of the amplifying means 4. A light detection control 32 to be performed, and a control table 33 that defines control modes of the light transmission control unit 31 and the light detection control 32;
An amplification factor table 34 for determining the amplification factor of the amplification means 4 is provided.

The control table 33 is, for example, a light-sending table 33a in which a combination of light-sending units for sending light and the order thereof are determined.
And a light receiving table 3 in which the order and the combination of the light receiving units are determined
3b is provided. It should be noted that instead of the individual tables of the light transmitting table 33a and the light receiving table 33b, a light transmitting / receiving table (not shown) that defines the combination and order of the light transmitting units and the combination and order of the light receiving units as one table is provided. You can also

In the control table 33, regarding the control relating to light emission, the combination and operation sequence of the light-transmitting units that simultaneously transmit light are determined from among the plurality of light-transmitting units 22a arranged in the light-transmitting / receiving unit 22. Regarding the control related to the light detection, the combination of the light receiving units that use the light receiving signals obtained by receiving light by the plurality of light receiving units 22b arranged in the light transmitting and receiving unit 22 as valid data and the operation order are determined.

The light-sending control unit 31 controls the light emission of the light-emitting unit 21 based on the combination of the light-sending units received from the light-sending table 33a and the operation order. Further, the light receiving control unit 32
Based on the combination of the light receiving units received from the light receiving table 33b and the operation order, the light receiving unit 22b receives the light and the light detecting unit 2 receives the light.
The received light signal obtained by conversion in 3 is controlled. Further, in the amplification factor table 34, the amplification factor for amplifying the signal in each light receiving unit is set. The amplification factor may be set according to the combination of the light transmitting unit and the light receiving unit defined in the light transmitting table 33a and the light receiving table 33b and the operation order, or may be set independently of the combination of the light transmitting unit and the light receiving unit. It can also be in the form.

A description will be given below using a combination of a plurality of light transmitting points and light receiving points shown in FIG. Note that irradiation can be performed at different wavelengths at each light transmitting point, but here, a simplified model of extremely simple light transmitting and receiving arrangement is used for description. The combination of the light transmitting point and the light receiving point in FIG.
The measurement example which consists of B and C and the light-receiving parts 1, 2, and 3 is shown. There are 9 (= 3 × 3) possible combinations of light transmission and reception in this combination, but seven of them (arrows CH1 to CH7 in FIG. 2) are to be measured.
Further, the optical signal intensity of the light receiving portion obtained by the combination of each light transmitting and receiving is represented by the thickness of the arrow, the ratio of the optical signal intensity of the thick arrow is 100: 1, and the light signal intensity of the thin arrow is 100: 1. It is assumed that the measurement is started by adjusting the amplified signal strength to 0 to 100 (noise not depending on the signal strength is ± 1).

In this example, when the signal amplification is performed at a constant signal amplification rate in the light receiving section as in the conventional case, the light transmission table, the light reception table, and the amplification rate shown in Table 1 below are set.

[0030]

[Table 1]

In Table 1, the light transmission table is Step 1
3 to 3 indicate which light transmitting section is irradiated, and similarly the light receiving table indicates whether or not data is acquired by each light receiving section in each step. In the example of Table 1, step 1
In step 2, the light is emitted from only the light transmitting section 1 (circle in the figure), in step 2, only the light transmitting section 2 is irradiated, and in step 3, only the light transmitting section 3 is irradiated. On the other hand, regarding the light receiving unit, in Step 1, the light receiving unit 1,
The data of No. 2 is acquired (marked with a circle in the figure), and in step 2, all of the light receiving units 1, 2, 3 are acquired. Also, step S3
2 is acquired by the light receiving units 2 and 3. The numbers in the brackets of the light receiving table indicate the light intensity detected by each light receiving unit.

By using the light sending table and the light receiving table, for example, preliminary measurement is performed to check the light intensity detected by each light receiving section, whereby the amplification factor set for each light receiving section can be obtained. However, in Steps 1 to 3, it is necessary to perform all the measurements within the above-mentioned measurement range, so the amplification factor set for each light receiving unit is determined by the detected light intensity that is the maximum in each step. In the example of the table, since the detected light intensity 100 in step 1 is maximum for the light receiving section 1, the amplification factor to be set is 1, and for the light receiving sections 2 and 3, 10 is set for each.
The amplification factor is 0 and 1. Table 2 shows the results measured under the conditions determined in Table 1. The numbers in parentheses in Table 2 indicate the magnitude of signal intensity obtained by amplification.

[0033]

[Table 2]

As is clear from the results shown in Table 2, CH1 and CH3 to CH5, CH7, etc. have a signal strength of 100 and a good S / N measurement, but for CH2 and 6 only signals equivalent to the noise level are obtained. It is not possible to measure, and the measurement is performed in an extremely poor S / N state.

Next, an example to which the present invention is applied is shown in FIG.
And Tables 3 and 4 will be described. In this example, an amplification factor table is set for each step in addition to the light transmission table and the light reception table. Table 3 shows each of these tables.

[0036]

[Table 3]

In creating the amplification factor table, similar to the application example of the above-mentioned prior art, by using the light transmitting table and the light receiving table, for example, preliminary measurement is performed to check the light intensity detected by each light receiving unit. Obtain the amplification factor to be set.

Further, in the measurement using the light sending table, the light receiving table, and the amplification factor table, in addition to the control such as the selection of the light sending section for irradiation and the selection of the light receiving section for acquiring data, amplification is performed. Amplification rate switching control according to the rate table is also performed to acquire data.
Table 4 shows the measurement results obtained by this. Further, FIG. 3 shows the setting state of the amplification factor and the signal strength in each of the steps 1 to 3.

[0039]

[Table 4]

As shown in Table 4 and FIG. 3, almost the same signal strength can be obtained by measurement by any combination of light transmission and reception. In actual measurement, there is noise that is dependent on the light intensity in addition to noise that is not related to the detected light intensity. Generally, when the light intensity becomes weaker, the S / N decreases, so that an equivalent S / N may not be obtained even in the measurement by an arbitrary combination of light transmission and reception. It is possible to avoid S / N deterioration due to noise irrelevant to the intensity.

Next, regarding another example to which the present invention is applied,
This will be described with reference to FIG. 4 and Tables 5 and 6. In this example, in addition to the light sending table and the light receiving table, an amplification rate table is set independently of the light sending table and the light receiving table, the light sending table and the light receiving table are combined with the amplification rate table, and amplification is performed according to the amplification rate table. This is an example of measuring by switching the rate.

In a system in which it takes a long time to switch the amplification factor for each light receiving unit, if the amplification factor is switched at each step, the switching time becomes rate-determining, and steps 1 to
When 3 is repeated and continuous measurement is performed, the sampling interval (the time from when step 1 is performed until step 1 is performed again) becomes long, which causes a problem that the measurement time becomes long. For example, when the amplification factor is changed by switching the negative high voltage of the photomultiplier tube, it takes time from the switching of the negative high voltage until the amplification factor becomes stable.

The present example eliminates the lengthening of the measurement time associated with such switching of the amplification factor. In this example, as shown in (a) of Table 5, control is performed by a table that switches the amplification rate in a cycle different from the steps of the light transmission table and the light reception table.

[0044]

[Table 5]

(B) in Table 5 shows the relationship between the steps of the light transmitting table and the light receiving table and the cycle of the amplification factor. The measurement of steps 1 to 3 (for example, cycle a) is performed with a certain combination of amplification factors, and then the amplification factor is switched and the measurement of steps 1 to 3 (for example, cycle b) is performed similarly.

Table 6 shows the obtained measurement data. Further, FIG. 4 shows the setting state of the amplification factor and the signal strength in each of the steps 1 to 3.

[0047]

[Table 6]

According to the results shown in Table 6 and FIG. 4, as to the measurement data for the combination (CH1 to CH7) of the light transmitting / receiving points, by selecting the data in the appropriate cycle and the appropriate step, the above Table 4 is obtained. You can get the same result.

In Table 6, the signal strength obtained by amplification is selected on the basis of 100, data having a signal strength of 1 is rejected as noise, and data having a signal strength of 1000 is saturated. Reject as. In the table, in the data collected based on the light receiving table, the data thus rejected is indicated by Δ.

Even in the embodiment using the amplification factor table combined with the light transmission table and the light reception table shown in Table 3 above, the system in which the amplification factor switching performed in Table 6 takes a long time is performed. Corresponding and equivalent measurements can be performed. Table 7 below shows the “light transmitting table”, “light receiving table”, and “amplification factor table” in this case.

[0051]

[Table 7]

According to the above example, for example, the amplification rate switching of three times performed in Table 3 can be switched to two times, and the sampling interval is set in the system in which the amplification rate switching time is rate-determining. Can be shortened.

Next, regarding another example to which the present invention is applied,
This will be described with reference to Table 8. In the examples shown in Tables 5 and 6, the cycle switching and the start of steps 1 to 3 are synchronized, but the same measurement can be performed even when these cycles and steps are not completely synchronized. Table 8 shows the amplification factor cycle, the steps of transmitting and receiving light, and the switching state.

[0054]

[Table 8]

In this example, the cycle time for switching the amplification factor is set to be longer than the time required for performing steps 1 to 3 of light transmission / reception, so that the data indicated by the bold line frame in Table 8 is extracted. It is possible to obtain the same result as that of (b).

Each of the above-mentioned examples is a structural example in which a proper signal intensity is obtained by amplifying the detected optical signal converted into an electric signal by the detector. It is also possible to use an attenuator to obtain a proper signal strength.

FIGS. 5 and 6 and Table 9 show an example including an optical attenuator. The schematic configuration diagram shown in FIG. 5 is almost the same as the schematic configuration diagram of FIG. 1 described above. Instead of the amplifying means 4, an attenuating means such as an optical attenuator is provided between the light receiving section 22b and the light detecting section 23. 8 is provided, and an attenuation rate table 35 is provided in the control means 3 instead of the amplification rate table. The attenuator 8 attenuates each received light signal based on the attenuation rate set in the attenuation rate table 35, and then sends it to the photodetector 23.

Table 9 shows an example of the attenuation rate table, and FIG. 6 shows the setting state of the attenuation rate and the signal strength in steps 1 to 3. The attenuation rate table in Table 9 is
Although it is set corresponding to the combination of the light sending table and the light receiving table, it is set independently of the light sending table and the light receiving table in the same manner as the amplification rate table described above, and the cycle of the attenuation rate and the steps of light sending and receiving are set. Can be performed synchronously or asynchronously.

[0059]

[Table 9]

Furthermore, a configuration is obtained in which a proper signal intensity is obtained by amplifying the detection light signal converted into an electric signal by the detector, and the light intensity itself incident on the detector is adjusted by an optical attenuator to obtain a proper signal intensity. It is also possible to adopt a configuration in which a configuration for obtaining signal strength is combined.

FIGS. 7 and 8 and Table 10 show an example including an amplifying means and an attenuating means. The schematic configuration of the optical measuring device shown in FIG. 7 includes both the amplifying unit included in FIG. 1 and the attenuating unit included in FIG. 5 described above, and further includes an amplification factor table 34 and an attenuation factor table 35 in the control unit 3. .
The attenuator 8 attenuates each received light signal based on the attenuation rate set in the attenuation rate table 35, and then sends it to the photodetector 23. Further, the amplification means 4 performs signal amplification based on the amplification rate set in the amplification rate table 34. Table 10 shows an example of the attenuation rate table and the amplification rate table, and FIG.
The setting state of the attenuation rate and the amplification rate and the signal strength in one step are shown.

[0062]

[Table 10]

Generally, it is S / N to weaken the light intensity itself.
Is not suitable for measurement, but it is considered that there is little influence of the S / N reduction due to attenuation for signals with extremely strong light intensity. Therefore, the attenuation rate table and the amplification rate table are By combining the above, more effective measurement results are desired.

An example of improving S / N by the optical measuring device according to the present invention will be described with reference to FIG. FIG. 9 is an example of a transmission / reception arrangement model with 6 transmissions and 6 receptions.
There are 36 (= 6 × 6) combinations of light transmission / reception that can be considered in the arrangement of the light transmission point and the light reception point. In this combination, the combination of the most adjacent light emitting and receiving (16 patterns shown in FIG. 9A) and the combination of the next adjacent light emitting and receiving (FIG. 9).
In (16 types shown in (b)), there is a problem that the intensity difference of the detection light is large, and it is difficult to measure S / N well in a mixed state.

The optical measuring device of the present invention can measure with a good S / N even in such a case, and it is said that the information about the depth direction, which is said to be observed in proportion to the distance between the transmitting and receiving points. Can also be measured. For example, in FIG.
Since (a) and (b) have different transmission and reception distances, the depth information of the measured optical signal is different. Further, even in measurement at almost equal distances, there is a possibility that the S / N deterioration can be improved due to the difference in the detected light intensity depending on the installation state of the fiber and the irradiation wavelength.

[0066]

As described above, according to the optical measuring device of the present invention, in the optical measuring device having a plurality of light transmitting points and a plurality of light receiving points, the light transmitting section, the light receiving section, or between the light transmitting and receiving sections, etc. Even when the conditions for transmitting and receiving light are different, the optimum signal strength level can be obtained.

[Brief description of drawings]

FIG. 1 is a schematic configuration diagram for explaining a configuration example of an optical measurement device of the present invention.

FIG. 2 is a model of a light transmitting / receiving arrangement for explaining a combination of a plurality of light transmitting points and light receiving points.

FIG. 3 is a diagram showing a setting state of an amplification factor and a signal intensity in each step by the optical measuring device of the present invention.

FIG. 4 is a diagram showing a setting state of an amplification factor and a signal intensity in each step by the optical measuring device of the present invention.

FIG. 5 is a schematic configuration diagram for explaining one configuration example of the optical measurement device of the present invention.

FIG. 6 is a diagram showing a setting state of an attenuation rate and a signal intensity in each step by the optical measuring device of the present invention.

FIG. 7 is a schematic configuration diagram for explaining one configuration example of the optical measurement device of the present invention.

FIG. 8 is a diagram showing a setting state of an attenuation rate and an amplification rate and a signal intensity by the optical measurement device of the present invention.

FIG. 9 is a diagram for explaining an example of improving S / N by the optical measurement device according to the present invention.

FIG. 10 is a diagram showing a configuration example of a detector included in a conventional multi-channel optical measurement device.

FIG. 11 is a schematic diagram for explaining a light transmitting point and a light receiving point.

[Explanation of symbols]

1 ... Optical measuring device, 2 ... Transmitting / receiving means, 3 ... Control means, 4 ...
Amplifying means, 5 ... Signal acquiring means, 6 ... Recording means, 7 ... Displaying means, 21 ... Light emitting part, 22 ... Light emitting / receiving part, 22a ... Light sending part, 22b ... Light receiving part, 23 ... Light receiving part, 31 ... Sending Light control unit, 32 ... Light reception control unit, 33 ... Control table, 33a ...
Light sending table, 33b ... Light receiving table, 34 ... Amplification rate table, 35 ... Attenuation rate table

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Sadao Takeuchi             1 Nishinokyo Kuwabaracho, Nakagyo Ward, Kyoto City, Kyoto Prefecture             Shimadzu Corporation (72) Inventor Naofumi Sakauchi             1 Nishinokyo Kuwabaracho, Nakagyo Ward, Kyoto City, Kyoto Prefecture             Shimadzu Corporation (72) Inventor Yukihisa Wada             1 Nishinokyo Kuwabaracho, Nakagyo Ward, Kyoto City, Kyoto Prefecture             Shimadzu Corporation F term (reference) 2G059 AA05 BB12 CC16 EE01 EE02                       EE11 FF04 GG03 GG10 JJ17                       KK03 LL04 NN01

Claims (4)

[Claims] 1. An optical measuring device for irradiating a subject with light and measuring the light emitted to the outside after being transmitted and / or reflected in the subject, wherein the subject is irradiated with light of one or a plurality of wavelengths. Transmitting and receiving means having a plurality of transmitting parts for irradiating and a plurality of receiving parts for receiving light emitted from the subject, and a plurality of amplifying means for amplifying the measurement signals measured by the respective receiving parts, And / or a plurality of attenuating means for respectively attenuating the light intensity incident on each of the light receiving parts, and changing each amplification factor of the amplification means and / or each attenuation factor of the attenuation means during measurement. Characteristic optical measuring device. 2. A control unit for controlling the light transmission / reception of the light transmission / reception unit, and the amplification factor of the amplification unit or the attenuation factor of the attenuation unit, wherein the control unit transmits / receives an irradiation wavelength. A control table that defines the combination and order of the light unit and the light receiving unit, an amplification factor table that defines the amplification factor corresponding to the combination set in the control table, and / or an attenuation corresponding to the combination set in the control table. An attenuation rate table that defines a rate, the control means performs light transmission / reception control based on the irradiation wavelength and / or the combination and order of the light transmission section and the light reception section defined in the control table, and the control is performed. In synchronization with the control of the table, the amplification factor set in the amplification factor table is set in each of the amplification means, and / or the attenuation factor set in the attenuation factor table is set in each of the amplification factors. The optical measuring device according to claim 1, wherein the optical measuring device is set in an attenuation rate means. 3. A control unit for controlling the light transmission / reception of the light transmission / reception unit, and the amplification factor of the amplification unit and / or the attenuation factor of the attenuation unit, wherein the control unit controls the irradiation wavelength and / or the light transmission / reception. A control table that defines the combination and order of the light-transmitting unit and the light-receiving unit to perform, and an amplification factor table that defines at least one combination of the amplification factors of the amplification means, and /
Or an attenuation rate table that defines at least one combination of attenuation rates of the respective attenuation means, and the control means,
A combination of an irradiation wavelength and / or a combination and order of a light transmitting unit and a light receiving unit defined in the control table, and a combination of an amplification factor defined in the amplification factor table and / or an attenuation factor defined in the attenuation factor table. And transmitting / receiving control, and performing amplification factor setting and / or attenuation factor setting based on a combination of the control table and the amplification factor table, and / or a combination of the control table and the attenuation factor table. The optical measuring device according to claim 1. 4. The switching of each combination of the control table and the amplification factor table and / or the attenuation factor table is performed synchronously or asynchronously.
The optical measurement device described.