CN112485206B - Correction method of contact type measuring device and percutaneous jaundice instrument - Google Patents
Correction method of contact type measuring device and percutaneous jaundice instrument Download PDFInfo
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- 206010023126 Jaundice Diseases 0.000 title claims abstract description 58
- 238000000034 method Methods 0.000 title claims abstract description 40
- 238000012937 correction Methods 0.000 title claims abstract description 22
- 238000005070 sampling Methods 0.000 claims abstract description 107
- 239000000523 sample Substances 0.000 claims abstract description 56
- 238000005259 measurement Methods 0.000 claims abstract description 27
- 238000012545 processing Methods 0.000 claims abstract description 18
- 230000000630 rising effect Effects 0.000 claims abstract description 18
- 238000012360 testing method Methods 0.000 claims description 21
- 238000004364 calculation method Methods 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 7
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 16
- 210000003491 skin Anatomy 0.000 description 15
- 238000010521 absorption reaction Methods 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 3
- 108010054147 Hemoglobins Proteins 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 230000001133 acceleration Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000000265 homogenisation Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 235000013405 beer Nutrition 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000009499 grossing Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000013524 data verification Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
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Abstract
The invention provides a correction method of a contact type measuring device and a percutaneous jaundice instrument, wherein the correction method comprises the following steps: dynamic pressure data and probe data at the probe of the contact type measuring device are collected at the same time at a set frequency, corresponding pressure sampling values and probe data at continuous collection time points are recorded, continuous probe data of a pressure rising section are intercepted, and data processing is carried out to obtain corrected probe data. By adopting the technical scheme of the invention, the pressure value of the probe to the skin is synchronously acquired in the measurement process, so that the percutaneous jaundice value of the percutaneous jaundice measuring instrument is corrected, the accuracy of the measurement data of the percutaneous jaundice measuring instrument is improved, and the consistency and the repeatability are improved.
Description
Technical Field
The invention belongs to the technical field of instruments and meters, and particularly relates to a correction method of a contact type measuring device and a percutaneous jaundice instrument.
Background
The existing percutaneous bilirubin detection products adopt a dual-wavelength method, and the principle is as follows: according to absorbance of each substance of human skin tissue, the bilirubin has strong absorption effect on blue light with the wavelength of 460nm, and according to the lambert beer law, the bilirubin concentration value has a certain relation with the absorbance with the wavelength of 460nm, but meanwhile, the absorption of part of the hemoglobin at 460nm is considered, so that certain influence on the absorption condition of the bilirubin can be caused on the wavelength, the interference measurement is carried out, in order to remove the influence of the hemoglobin, the wavelength of 530nm is taken as a second wavelength, because the absorption capacity of the hemoglobin is the same as the former and no bilirubin is absorbed, the light absorption difference value of the two wavelengths in the skin tissue is obtained to obtain bilirubin concentration related signals, and the bilirubin concentration value is obtained by linear relation with the bilirubin concentration. In the existing percutaneous jaundice instrument product, a certain pressure is required to be applied to a jaundice probe during measurement, so that the probe can be tightly attached to skin, light leakage can be reduced, and the sensor can be facilitated to detect more signal quantity. However, for the reflective percutaneous jaundice measuring instrument, when a blue-green bicolor LED is used as a light source, bicolor light alternately works, blue light and green light signals are acquired in a time-sharing way, the whole testing time is 800ms to 1600ms, and based on the consistency requirement of measurement, the whole process of a tester in all the tests cannot keep the same pressure level, so that the pressure change cannot be ignored. Further, as is known from lambert beer's law, when the wavelength of incident light, the concentration of the solution, and the temperature are constant, the absorbance of the solution is proportional to the thickness of the liquid layer. The pressure of the percutaneous jaundice probe acting on the skin surface enables the probe to be tightly attached to the skin, and meanwhile, the skin at the probe is deformed and sunk, so that the length of an optical path (namely the optical path) in the skin is changed, the length and the length change of the optical path in the skin are not measured, the pressure is changed, and the accuracy, the consistency and the repeatability of the measured value are affected. Also, the same problem exists for contact measuring instrument blood oxygen saturation test instruments.
Disclosure of Invention
Aiming at the technical problems, the invention discloses a correction method of a contact type measuring device and a percutaneous jaundice instrument, and the influence of pressure on a measuring result in measurement is considered, so that the measuring result is more accurate and has better consistency and repeatability.
In this regard, the invention adopts the following technical scheme:
a method of calibrating a contact measurement device, comprising:
dynamic pressure data and probe data at the probe of the contact type measuring device are collected at the same time at a set frequency, corresponding pressure sampling values and probe data at continuous collection time points are recorded, continuous probe data of a pressure rising section are intercepted, and data processing is carried out to obtain corrected probe data. The pressure sampling value here is such data as a signal obtained by sampling the pressure or a pressure value.
By adopting the technical scheme, the influence of pressure on test data in the test is considered, the pressure is synchronously sampled when the probe is used for sampling, continuous probe data of a pressure rising section are intercepted, the data are processed, and the accuracy, the consistency and the repeatability of the test result are improved. The method can be used for contact measuring instruments such as percutaneous jaundice and blood oxygen saturation measuring instruments using light reflection measuring methods.
As a further improvement of the present invention, the data processing includes processing the probe data of the pressure rising section by an arithmetic average method, a weighted average method, or a uniform method.
As a further development of the invention, the acquisition of probe data is started when the pressure sampling value is greater than a preset starting pressure sampling value.
As a further development of the invention, the acquisition is stopped and the measuring state is exited when the pressure sampling value is greater than a preset cut-off pressure sampling value.
As a further improvement of the invention, the contact type measuring device is a percutaneous jaundice measuring instrument, after the probe contacts the skin, pressure is generated between the probe and the skin, the pressure is gradually increased in the pressing process, when the pressure sampling value is larger than a preset initial pressure sampling value, the blue-green double-color light source emits alternately, and the reflected light value of blue light, the pressure sampling value, the reflected light value of green light and the pressure sampling value are collected and recorded; intercepting sampling values of a pressure rising section from recorded data, calculating percutaneous jaundice values of each sampling value of the pressure rising section, performing pressure correction data calculation processing to obtain final percutaneous jaundice values, or performing pressure correction data calculation processing on blue light sampling data and green light sampling data, and then calculating to obtain final percutaneous jaundice values. Wherein the data processing includes data processing by an arithmetic average method, a weighted average method, or a uniform method.
When the pressure sampling value is larger than a preset initial pressure sampling value, starting data acquisition of the probe, firstly lighting a blue light/green light, acquiring a reflected light value and the pressure sampling value of the blue light/green light, then turning off the blue light/green light, lighting the green light/blue light, acquiring the reflected light value and the pressure sampling value of the green light/blue light, then turning off the green light/blue light, calculating a pressure average value, storing the reflected light value of the blue light, the reflected light value of the green light and the pressure average value into a data list, and circularly acquiring data; and (3) until the pressure sampling value is increased to a preset cut-off pressure sampling value, completing the test, intercepting the pressure rising section data in the data list and calculating.
Further, when the set sampling time is reached, or the collected pressure sampling value is greater than the cut-off pressure sampling value, or the collected pressure sampling value is smaller than the starting pressure sampling value, the collection is stopped.
As a further improvement of the present invention, the pressure sampling time points may be at the beginning of the blue light and green light sampling, in the middle of the blue light and green light sampling, at the end of the blue light sampling, or at the end of the green light sampling, and one or more time points may be selected for the acquisition.
As a further development of the invention, the preset starting pressure sampling value is 700 to 900 and the preset cut-off pressure sampling value is 1500 to 1800. Further, the starting pressure sampling value is 900, and the cutoff pressure sampling value is 1500. The initial pressure sampling value and the cut-off pressure sampling value are AD sampling values, and represent certain pressure values.
The invention also discloses a percutaneous jaundice instrument which comprises a probe and a host, wherein the probe is provided with a blue-green double-color LED lamp, an LED driving module, a photoelectric sensor and a pressure sensor, a processor is arranged in the host, and the processor obtains a corrected result by adopting the correction method of the contact type measuring device based on pressure correction.
As a further improvement of the invention, the photoelectric sensor is positioned at the center of the probe, the blue-green LED lamps are positioned at the periphery of the photoelectric sensor, and the pressure sensor is positioned at the rear part of the probe;
the pressure sensor is connected with the processor through an AD sampling circuit, the photoelectric sensor is connected with an amplifying and filtering circuit, the amplifying and filtering circuit is connected with the processor through the AD sampling circuit, and the blue-green double-color LED lamp is connected with the processor through an LED driving module.
Further, at the center of the probe, a plurality of blue-green bicolor LEDs are arranged in four directions of the photoelectric sensor PD with the photoelectric sensor PD as the center, and the probe is perpendicular to the skin surface.
As a further improvement of the invention, a 3-axis acceleration sensor (such as MMA7660 FC) is added on the probe, so that the posture of the probe during measurement can be detected, the 3-axis acceleration sensor is connected with the processor, the interference of the weight of the probe on the pressure output is corrected by adopting the data fed back by the 3-axis acceleration sensor, and the accuracy of the measured value is improved.
Compared with the prior art, the invention has the beneficial effects that:
by adopting the technical scheme of the invention, the pressure value of the probe to the skin is synchronously acquired in the measurement process, so that the percutaneous jaundice value of the percutaneous jaundice measuring instrument is corrected, the accuracy of the measurement data of the percutaneous jaundice measuring instrument is improved, and the consistency and the repeatability are improved.
Drawings
Fig. 1 is a flowchart of a method for calibrating a percutaneous jaundice measuring instrument according to an embodiment of the invention.
Fig. 2 is a block diagram of a percutaneous jaundice measuring apparatus according to an embodiment of the present invention.
Fig. 3 is a schematic diagram of a percutaneous jaundice measuring instrument according to an embodiment of the present invention.
Fig. 4 is a sampling timing chart of a percutaneous jaundice measuring instrument according to an embodiment of the invention.
Fig. 5 is a graph of percutaneous jaundice versus pressure versus time obtained after multiple measurements of the same skin location in accordance with an embodiment of the present invention.
FIG. 6 is a graph of percutaneous jaundice value versus time after pressure correction according to an embodiment of the present invention.
Detailed Description
Preferred embodiments of the present invention are described in further detail below.
A method of calibrating a pressure sensor-based touch measurement device, comprising:
and simultaneously acquiring pressure data and probe data at the probe of the contact type measuring device at a set frequency, recording and obtaining corresponding pressure sampling values and probe data of continuous acquisition time points, intercepting continuous probe data of a pressure rising section, and carrying out data processing to obtain corrected probe data. Wherein the data processing includes processing probe data of the pressure rising section by an arithmetic average method, a weighted average method or a uniform method.
And when the pressure sampling value is larger than the preset initial pressure sampling value, starting to collect probe data. And stopping collecting when the pressure sampling value is larger than a preset cut-off pressure sampling value.
The percutaneous jaundice measuring instrument will be specifically described below as an example.
The percutaneous jaundice measuring instrument is shown in fig. 2, and comprises a probe and a host, wherein the probe is provided with a blue-green double-color LED lamp, an LED driving module, a photoelectric sensor and a pressure sensor, a processor is arranged in the host, the photoelectric sensor is positioned at the center of the probe, the blue-green double-color LED lamp is positioned around the photoelectric sensor, and the pressure sensor is positioned at the rear part of the probe; the pressure sensor is connected with the processor through an AD sampling circuit, the photoelectric sensor is connected with an amplifying and filtering circuit, the amplifying and filtering circuit is connected with the processor through the AD sampling circuit, and the blue-green double-color LED lamp is connected with the processor through an LED driving module. The photoelectric sensor receives the reflected light signal, converts the reflected light signal into an output signal, amplifies and filters the output signal to be used as an input, and converts a pressure signal fed back by the pressure sensor into a voltage signal to be used as an input. Furthermore, the percutaneous jaundice measuring instrument can be connected with a PC through a communication interface (UART), the sampled data and the calculation result are sent to the PC for storage and analysis, and the key is used for starting a measuring mode.
As shown in fig. 3, when the measurement is performed, the blue-green LED lamps alternately emit blue-green bi-color light, and the blue-green bi-color light is reflected by the epidermis layer and the dermis layer and then reaches the photoelectric sensor, the photoelectric sensor outputs a signal, and the signal is filtered and amplified by the filtering and amplifying circuit to be used as input of the AD sampling, so that the blue light and the green light alternately emit light, and the blue light and the green light values are alternately collected, and the pressure is synchronously sampled when the bi-color light is sampled.
The processor may process the collected data according to a flow shown in fig. 1, and specifically includes:
starting from a standby state, and entering a testing state when a key action is detected; if a key operation is detected in the test state, the pressure is appliedAnd the sampling value is withdrawn from the test state when the sampling value is larger than or smaller than the preset initial pressure sampling value. In the test state, the test will start to be F s The sampling frequency (1000 Hz, for example) detects the pressure sensor, when the pressure sampling value reaches the initial pressure sampling value P b (for example, the AD sampling value of the initial pressure is set to be 700), the data acquisition is started, the blue lamp is firstly lighted, after the light intensity is stable (for example, 5 ms), the pressure sampling value and the blue light data are acquired, then the blue lamp is turned off, then the green lamp is lighted, after the light intensity is stable (for example, 5 ms), the pressure sampling value and the green light data are acquired, the specific time sequence is shown in fig. 4, then the green lamp is turned off, the pressure average value is calculated, the blue light value, the green light value and the pressure average value are stored in a list or uploaded to a PC, and the cycle is performed. When the pressure increases to the cutoff pressure sampling value P e When (for example, setting the sampling value of the cut-off pressure AD to 1800), setting the measurement completion mark Teste=1, and continuously circularly collecting data until the sampling value of the pressure is smaller than the sampling value P of the starting pressure b And stopping data sampling, judging whether the test is finished (test= =1 tb To P te The data list segment in the range (for example, the pressure AD sampling value is 900-1600) is used for data calculation and processing, so as to obtain the final value of the percutaneous jaundice measurement of the current measurement, and then the test state is re-entered.
As shown in the timing chart of fig. 4, the TestPeriod sampling period (16.6 ms) is a period of sampling the blue light value or the green light value once; blue_ctr and green_ctr are control signals of a Blue light and a Green light respectively, each time the Blue light and the Green light are lighted for 8.3ms, and the Blue light and the Green light are lighted alternately; the BG-ADC is a blue light and green light sampling signal, the sampling time length of each sampling is 3.2ms, the total sampling is 32 times, and the sampling values are used for calculating the average value to alternately obtain the blue light and green light; pressure_adc is a Pressure sensor sampling signal, and Pressure sampling is performed once before and after the start and end of blue-green light sampling, respectively. Thus, one complete sampling period is 16.6x2=33.2 ms, and the sampling frequency is 30Hz.
Fig. 5 shows a percutaneous jaundice value versus pressure curve obtained after multiple measurements of the same skin site, wherein the percutaneous jaundice value curve is calculated from blue and green light values, and the curve is obtained by a homogenization treatment without consideration of the influence of pressure factors. It can be seen from the graph that the change period of the percutaneous jaundice value is basically consistent with the change period of the pressure value, and particularly in the pressure rising section, the percutaneous jaundice value rises, so that the percutaneous jaundice value has good regularity. The percutaneous jaundice value can thus be corrected using the pressure value.
Intercepting a pressure rising stage from a data acquisition list of one test, wherein a pressure sampling value is in P tb To P te The list segment of the interval (for example, the pressure AD sampling value is 900-1600) is processed by adopting a homogenization and smoothing data method based on the pressure sampling value, so as to obtain the final percutaneous jaundice measurement result of the current test. The percutaneous jaundice measurements were calculated for each of the tests in fig. 5, and wired to give fig. 6. The specific calculation process is as follows:
and calculating the percutaneous jaundice value of each group of data, adding the pressure sampling value, and performing calculation processing by using a homogenization and smoothing data method, wherein the obtained result is used as the final percutaneous jaundice measurement result of the current test. The specific calculation comprises the following steps:
assuming a data list segment of the truncated pressure interval, n groups of data are expressed as:
(b 1 ,g 1 ,p 1 ),(b 2 ,g 2 ,p 2 )......(b n ,g n ,p n )
wherein b 1 ,b 2 ...b n For the value of the blue light to be the value of,
g 1 ,g 2 ...g n for the value of green light,
p 1 ,p 2 ...p n as a sampling value of the pressure,
the calculation formula of percutaneous jaundice value: j=f (b, g) where j is the percutaneous jaundice value, b is the blue value, and g is the green value.
Wherein j is 1 j 2 ...j n The percutaneous jaundice value calculated by each group of data is as follows:
J＝F{(j 1 ,p 1 ),(j 2 ,p 2 ),……,(j n ,p n )}，
wherein F may be a function of the uniform and smoothed data.
Likewise, the blue and green light values may be pressure corrected before the final percutaneous jaundice value is calculated.
B. G represents the blue light value and the green light value after pressure correction, respectively, then:
B＝F{(b 1 ,p 1 ),(b 2 ,p 2 ),……,(b n ,p n )}
G＝F{(g 1 ,p 1 ),(g 2 ,p 2 ),……,(g n ,p n )}
final percutaneous jaundice value:
J＝f(B,G)
the corrected final percutaneous jaundice values of both modes are consistent.
As can be seen from fig. 6, the pressure correction has a good convergence effect on the measurement value of the percutaneous jaundice, the measurement result before the correction varies with the pressure and is distributed in the range of 2.7 to 4.5, and the measurement result after the pressure correction is distributed in the range of 3.5 to 3.7, so that good consistency and repeatability results are shown.
In addition, the person and skin positions were changed, the above test was repeated, and the same results were obtained by data verification.
In this embodiment, the pressure rising section is selected to be a section with a pressure sampling value of 900 to 1600, and data of other pressure sections may be selected to perform correction, so long as the data of the rising section is continuous in the pressure curve. In addition, the percutaneous jaundice value can be calculated by using the blue light value and the green light value, and then the pressure correction is carried out to obtain the final percutaneous jaundice value, or the final percutaneous jaundice value can be calculated by using the corrected blue light value and green light value by using the same pressure correction method as the method for correcting the percutaneous jaundice value.
In conclusion, the correction method provided by the embodiment of the invention can effectively solve the problems of accuracy, consistency and repeatability in percutaneous jaundice measurement using blue-green double-color light as a light source.
The foregoing is a further detailed description of the invention in connection with the preferred embodiments, and it is not intended that the invention be limited to the specific embodiments described. It will be apparent to those skilled in the art that several simple deductions or substitutions may be made without departing from the spirit of the invention, and these should be considered to be within the scope of the invention.
Claims (5)
1. A method for calibrating a contact measurement device based on pressure calibration, comprising:
simultaneously acquiring dynamic pressure data and probe data at a probe of a contact type measuring device at a set frequency, recording and obtaining corresponding pressure sampling values and probe data of continuous acquisition time points, intercepting continuous probe data of a pressure rising section, and performing data processing to obtain corrected probe data;
the data processing comprises the steps of processing probe data of a pressure rising section by adopting an arithmetic average method, a weighted average method or a uniform method;
when the pressure sampling value is larger than a preset starting pressure sampling value, starting to collect probe data, and when the pressure sampling value is larger than a preset cut-off pressure sampling value, stopping collecting;
the contact type measuring device is a percutaneous jaundice measuring instrument, when the pressure sampling value is larger than a preset initial pressure value, blue-green double-color light sources emit alternately, and meanwhile, reflected light values and pressure data of blue light and reflected light values and pressure data of green light are collected and recorded; intercepting sampling values of a pressure rising section from recorded data, calculating percutaneous jaundice values of each sampling value of the pressure rising section, and performing pressure correction data calculation processing to obtain final percutaneous jaundice values; or firstly, carrying out data processing of pressure correction on the blue light sampling data and the green light sampling data, and then calculating to obtain a final percutaneous jaundice value;
when the pressure sampling value is larger than a preset initial pressure sampling value, starting data acquisition of a probe, firstly lighting a blue light/green light, acquiring reflected light value and pressure data of the blue light/green light, then turning off the blue light/green light, lighting the green light/blue light, acquiring reflected light value and pressure data of the green light/blue light, then turning off the green light/blue light, calculating a pressure average value, and storing the reflected light value of the blue light, the reflected light value of the green light and the pressure average value into a data list, thus circulating; and (3) until the pressure sampling value is increased to a preset cut-off pressure sampling value, completing the test, intercepting the pressure rising section data in the data list and calculating.
2. The method for calibrating a pressure calibration-based touch measurement device according to claim 1, wherein: the pressure sampling time points can be at the beginning of blue light and green light sampling, the middle of blue light and green light sampling, the end of blue light sampling or the end of green light sampling, and one or more time points can be selected for collection.
3. The method for calibrating a pressure calibration-based touch measurement device according to claim 1, wherein: the preset initial pressure sampling value is 700-900, and the preset cut-off pressure sampling value is 1500-1800.
4. A percutaneous Huang Dayi, characterized by: the pressure calibration-based contact type measuring device comprises a probe and a host, wherein the probe is provided with a blue-green double-color LED lamp, an LED driving module, a photoelectric sensor and a pressure sensor, a processor is arranged in the host, and the processor obtains a corrected result by adopting the pressure calibration-based contact type measuring device correction method according to any one of claims 1-3.
5. The percutaneous jaundice instrument of claim 4, wherein: the photoelectric sensor is positioned at the center of the probe, the blue-green double-color LED lamps are positioned at the periphery of the photoelectric sensor, and the pressure sensor is positioned at the rear part of the probe;
the pressure sensor is connected with the processor through an AD sampling circuit, the photoelectric sensor is connected with an amplifying and filtering circuit, the amplifying and filtering circuit is connected with the processor through the AD sampling circuit, and the blue-green double-color LED lamp is connected with the processor through an LED driving module.
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| Title |
|---|
| 新生儿经皮黄疸检测仪的校准;侯蕊;赵智慧;赵越;管西娟;胡文华;;上海计量测试(第02期);全文 * |
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|---|---|
| CN112485206A (en) | 2021-03-12 |
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