JP2003160421A - Sterilization liquid containing hypochlorous acid for dental treatment and antimicrobial method using inorganic antimicrobial agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an inexpensive, simple and safe disinfection method in oral cavities, dental chairs, dental treating apparatus, and an antimicrobial method for the dental treating apparatus, dental chair and their surroundings in a dental clinic that can develop sufficient microbicidal effect, retains the microbicidal and antimicrobial effects with the adverse effect on human bodies reduced. <P>SOLUTION: This sterilization liquid for a dental clinic is a hypochlorous acid-containing aqueous solution that contains chlorine in an amount of 10-1,000 ppm calculated as effective chlorine, has a pH adjusted to 2.0-8.0 with an acid. The dental treating apparatus or dental chairs further includes an inorganic antimicrobial agent of at least one selected from metal ions of Mn, Fe, Co, Ni, Cu and Zn in addition to use of the hypochlorous acid solution. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral disinfection, a treatment instrument, and a treatment table disinfection and treatment instrument in a dental clinic, and a treatment table and its peripheral antibacterial method.

[0002]

2. Description of the Related Art In recent years, the occurrence of infectious diseases in hospitals has become a serious problem. Even in the dental clinic, an effective disinfectant is required for the oral treatment, and there is a problem that bacteria disperse and contaminate the surrounding area during the oral treatment. Electrolyzed water has been proposed as a sterilizing solution. The electrolyzed water has insufficient sterilizing power, and there is a risk that chlorine gas will be generated when the electrolyzed water is generated, and it has a drawback that it is difficult to use in a dental clinic. In addition, a continuous sterilization method is required to prevent nosocomial infections. Although various antibacterial agents are known as a method of sustaining them, an organic antibacterial agent is not preferable because it is said that not only does the antibacterial action not last, but it also causes atopy and the like. In addition, silver-based antibacterial agents, which are used in large amounts for various purposes, are not preferable because silver reacts with chlorine ions when the antiseptic solution containing hypochlorous acid is applied, and the antibacterial effect is lost. As described above, the problem of preventing infectious diseases in dental clinics is urgent, but the bactericidal power is insufficient by the conventional method, and even if sufficient sterilization is performed, thereafter, there is a problem that the bacteria propagate. there were.

[0003]

[Problems to be Solved by the Invention] Intraoral disinfection in a dental clinic, treatment instrument, and disinfection of treatment table and treatment instrument,
(EN) An antibacterial method for a treatment table and its surroundings, which has a sufficient bactericidal effect, sustains the bactericidal / antibacterial effect, has less adverse effects on human health, and is inexpensive.

[0004]

Means for Solving the Problems The present inventor has a dental clinic which is a hypochlorous acid-containing aqueous solution having an effective chlorine concentration of 10 to 1000 ppm and a pH adjusted to 2.0 to 8.0 by addition of an acid. It has been found that the above-mentioned problems can be achieved by a sterilizing solution for use in food. Further, the dental treatment instrument, the dental treatment table and the vicinity thereof in the place where the sterilizing solution is used are Mn, Fe,
The above-mentioned problems can be better achieved by an antibacterial method for dental clinics in which the above-mentioned bactericidal effect is sustained by containing an inorganic antibacterial agent containing at least one kind of metal ions composed of Co, Ni, Cu and Zn. I found that I could do it. In the present invention, the terms antibacterial and sterilizing are used as terms including the concepts of antibacterial, antifungal, disinfecting, sterilizing, sterilizing, sterilizing and deodorizing.

The sterilizing solution of the present invention will be described. The effective chlorine concentration of the sterilizing solution is preferably 10 to 1000 ppm. Two
0-800ppm is more preferable, 30-300ppm
Is most preferred. Further, the pH is preferably 2.0 to 8.0, more preferably 4.0 to 7.2, and most preferably 4.5 to 6.5. It is desirable that the effective chlorine concentration is the minimum required concentration to exert the bactericidal effect. If the concentration is high, there is an unfavorable effect such as chlorine odor, and if the concentration is low, a sufficient bactericidal effect cannot be obtained. The bactericidal effect varies with temperature. At temperatures near room temperature, higher temperatures have a greater bactericidal effect. pH is an important factor that determines the concentration of undissociated hypochlorous acid. p
At H8 or higher, hypochlorous acid is dissociated and the bactericidal effect is significantly reduced. When the pH is 2 or less, chlorine is generated, which is harmful to the human body.

Hypochlorous acid is supplied as a hypochlorous acid salt or an aqueous solution of hypochlorous acid. The hypochlorous acid salt is not particularly limited, but sodium hypochlorite and potassium hypochlorite are preferable.

The pH of the sterilizing solution of the present invention is preferably adjusted by adding an inorganic acid such as hydrochloric acid, phosphoric acid, sulfuric acid or nitric acid, or an organic acid such as acetic acid, formic acid, citric acid or tartaric acid. . Although not usually required, an alkali such as sodium hydroxide can be added when the pH becomes too low. As the acid, hydrochloric acid, phosphoric acid, acetic acid, citric acid and tartaric acid are more preferable, hydrochloric acid and acetic acid are further preferable, and hydrochloric acid is particularly preferable. When adjusting these pHs, it is preferable to dilute both the acid and the alkali with water. In particular,
When adjusting the pH to between 5.0 and 7.0, it is preferable to use a sufficiently diluted acid.

An aqueous solution of acid and alkali, an aqueous solution of hypochlorous acid (preferably an aqueous solution of sodium hypochlorite) and water are mixed to prepare an aqueous solution of hypochlorous acid having a predetermined concentration and pH. It does not matter whether this preparation is carried out well before use or just before use. However, since hypochlorous acid in the aqueous solution of hypochlorous acid is unstable with respect to heat, light and an oxidizing agent, it is preferable to put it in a closed container, shield it from light and store it at a low temperature. It is preferable to use a sufficiently washed container. Further, in order to accurately adjust the concentration of each composition to a predetermined value, it is preferable to use a mixing device capable of adjusting the addition amount with high precision. With this device, the hypochlorous acid aqueous solution can be prepared immediately before use. In that case, an aqueous solution of acid or alkali, an aqueous solution of hypochlorous acid (preferably an aqueous solution of sodium hypochlorite) and water can be mixed, or an aqueous solution of acid or alkali and / or It is also preferable to use an aqueous solution of chlorous acid (preferably an aqueous solution of sodium hypochlorite) diluted with water to a predetermined concentration in advance. The method for adjusting the hypochlorous acid-containing sterilizing solution of the present invention is not particularly limited, but a sodium hypochlorite aqueous solution on one side of the container separated by a porous filter, water on the other side. A continuous mixing apparatus in which hydrochloric acid diluted with is added, and both solutions are gradually mixed through a filter to adjust to a predetermined pH is preferable. Further, these solutions are preferably stored in a closed container, and more preferably in the form of a cartridge which can be easily attached and detached.

The pH of the sterilizing solution of the present invention can be adjusted with a pH buffer. Also, the pH of the aqueous solution of hypochlorous acid
It is also preferred to use a pH buffer to adjust the pH. The pH buffer solution is a solution in which a change in pH (hydrogen ion concentration) when an acid or a base is added to the solution is smaller than a change in pH when an acid or a base is added to pure water. The pH buffer solution can be obtained by mixing an acid, a base, or a salt thereof. As an example of the pH buffering agent, any of those described in the second edition, pages 336 to 339, of the revised fourth edition of the Chemical Handbook (September 1993, Maruzen Publishing Co., Ltd.) is preferably used. it can.

The pH buffer solution includes alkali halides such as potassium chloride and sodium chloride, amino acids such as glycine, alanine, valine, leucine, isoleucine and cystine, inorganic acids such as hydrochloric acid, boric acid and phosphoric acid, lactic acid and malic acid. , Tartaric acid, citric acid, formic acid, butyric acid, acetic acid, succinic acid, diethylparbituric acid, potassium hydrogen phthalate,
Potassium hydrogen phthalate, sodium hydroxide, potassium hydroxide, potassium dihydrogen phosphate, sodium dihydrogen phosphate, dipotassium hydrogen phosphate, disodium hydrogen phosphate,
Trisodium phosphate, tripotassium phosphate, sodium citrate, potassium citrate, sodium dihydrogen citrate, potassium dihydrogen citrate, sodium tetraborate, potassium tetraborate, sodium tartrate, potassium tartrate,
Sodium lactate, potassium lactate, sodium acetate, potassium acetate, sodium dimethylparbiturate, potassium dimethylparbiturate, (2,4,6-trimethylpyridine), tris (hydroxymethyl) aminomethane, (2-amino- 2-methyl-1,3-propanediol), tris (hydroxymethyl) aminomethane,
It is preferably an aqueous solution containing at least two kinds of compounds in (3- [4- (2-hydroxyethyl) -1-propanesulfonic acid]). However, it is not limited to these.

The concentration of each component of these pH buffers is preferably any concentration as long as the required pH can be obtained. When used for a short period of time after opening, it is preferable that the concentration of each component of the pH buffer solution is low, and for a sterilizing solution for hands used for a long period after opening, the concentration of each component is preferably high. The method of mixing the components can be used in any order.
The hypochlorous acid may be mixed either after completion of the pH buffer solution or before completion. The mixing of hypochlorous acid and pH buffer may be done at any time prior to use.

It is also preferred that the hypochlorous acid aqueous solution contains a spreading agent. For the hypochlorous acid aqueous solution of the present invention. As the spreading agent, any of anionic, cationic, nonionic and betaine surfactants and water-soluble polymers are preferably used. The concentration of the spreading agent is preferably 20 to 2000 ppm. Linear alkyl benzene sulfonate, dialkyl succinate, lignin sulfonate, polynaphthyl sulfonate, sulfonate of alkyl ester of fatty acid (JP-A-2-167202, etc.) Alkyl sulfosuccinate-based anion, etc. System surfactant. Polyacrylic acid salt, alkyl sulfate, alkyl amine oxide, cationic surfactant such as chitosan having a degree of deacetylation of 30% or more and quaternary ammonium salt are preferably used. Among them, monoalkyl sulfate, trialkylamine-N-oxide, sodium fatty acid, and alkyltrimethylammonium are particularly preferable. Although the spreading agent may be added well before use, it is preferably added just before use. In actual use, it is preferable to mix it with an acid for pH adjustment or with dilution water. It is not preferable to add it to the aqueous solution of hypochlorous acid in advance because it may accelerate the decomposition of hypochlorous acid.

The preparation method of the sterilizing solution of the present invention is not particularly limited, but when it is stored after mixing, it is stored at a low temperature by blocking light, especially ultraviolet rays, and as an organic substance or an impurity such as protein or alcohol. It is preferable to minimize the amount of metal ions mixed in. Therefore, it is preferable to use thoroughly washed containers and instruments. When the hypochlorous acid-containing aqueous solution itself is also stored, it is preferable to block light, especially ultraviolet rays, and store at low temperature.

The sterilizing solution of the present invention preferably contains fluorine ions. The content is preferably 0.1 to 50 ppm, more preferably 0.1 to 15 ppm, and 0.1 to 5 p
pm is more preferable, and 0.2 to 2 ppm is the most preferable.

As the metal fluoride used for adding the fluorine ion, any metal fluoride that can be dissolved in water to release the fluorine ion can be used. Specifically, lithium fluoride and fluoride can be used. Sodium, potassium fluoride, rubidium fluoride, cesium fluoride, beryllium fluoride, magnesium fluoride, calcium fluoride, strontium fluoride, barium fluoride, aluminum fluoride, manganese (II) fluoride, iron fluoride (II ), Iron (III) fluoride, cobalt (II) fluoride, copper (II) fluoride, zinc fluoride, antimony (III) fluoride, lead fluoride (I)
I), silver (I) fluoride, cadmium fluoride, tin (II) fluoride, tin (IV) fluoride, silver diammine fluoride, ammonium fluoride, sodium hydrogen fluoride, ammonium hydrogen fluoride, hydrogen fluoride Potassium, sodium fluorophosphate, potassium hexafluorotitanate, sodium hexafluorosilicate, sodium hexafluorophosphate, sodium hexafluorotin (IV), hexafluorostannate (IV) alanine, sodium pentafluorodistannate (II) , Potassium hexafluorozirconate, etc. can be used.

Among these, lithium fluoride and sodium fluoride, which are fluorides of metals of Groups 1 and 2 of the periodic table,
Potassium fluoride, rubidium fluoride, cesium fluoride,
Beryllium fluoride, magnesium fluoride, calcium fluoride, strontium fluoride and barium fluoride are preferable, and among these, lithium fluoride, sodium fluoride and potassium fluoride are preferable, and sodium fluoride is particularly preferable. These metal fluorides can be used alone or in combination of several kinds.

The inorganic antibacterial agent used in the present invention is Mn,
An inorganic antibacterial agent containing at least one of metal ions consisting of Fe, Co, Ni, Cu and Zn is preferable. The metal ions are more preferably Cu and / or Zn, most preferably Zn. The content of the metal ion in these inorganic antibacterial agents is preferably 2 to 82% by weight. It is more preferably 20 to 82% by weight. These inorganic antibacterial agents are preferably oxides and / or hydroxides.

As the oxides and hydroxides used as these inorganic antibacterial agents, those represented by the following formulas (1) to (6) and ZnO are more preferable, and the following formulas (1) to (6) are more preferable. The following formulas (1), (4) and (5) are more preferable, the following formulas (4) and (5) are more preferable, and the following formula (4) is most preferable. M _x N _1-x O (1) (In the formula, N represents Mg and / or Ca, and M represents M.
It represents at least one kind of metal ion selected from the group consisting of n, Fe, Co, Ni, Cu and Zn, and x is 0.
02 <x <a _{0.8) M y N 1-x} (OH) 2 (2) ( wherein, M, N, x is the formula (1) is the same as) (In the formula, M is the same as the formula (1), L represents an alkali metal ion, and y is 0.0001 <y <0.1) (MO) · (Al ₂ O ₃ ) _a · ( SiO ₂ ) _b (4) (In the formula, M is the same as the formula (1). A is 0.00 ≦ a <5.
At 0, b is 0.00 ≦ b <80. However, a = 0
In the case of, b is 0.001 ≦ b <80, and in the case of b = 0, a is 0.001 ≦ a <50. ) (MO) · (XO ₂ ) _c (5) (In the formula, M is the same as the formula (1). X represents Ti and / or Zr. C represents 0.001 <c <0.2. .) (MO). (NO) _d. (Al ₂ O ₃ ) _e (6) (In the formula, M and N are the same as those in the formula (1). D is 0.05 ≦ d <
5, b is 0.01 ≦ b <5. ) In the above formulas (1) to (6), M is Cu or Zn.
Is more preferable, and Zn is further preferable. Further, N in the formulas (1) and (2) is more preferably Mg. It is preferable that L in the above formula (3) is Na or K. Further, a and b in the above formula (4) are more preferable, and a is 0.00 ≦ a <
In 2, b is 0.00 ≦ b <50. However, a = 0
In the case of, b is 0.001 ≦ b <50, and in the case of b = 0, a is 0.001 ≦ a <2. More preferably, a is 0.00 ≦ a <0.2 and b is 0.00 ≦ b <1. However, when a = 0, b is 0.001 ≦ b <1, and when b = 0, a is 0.001 ≦ a <0.2. )

Examples of preferred inorganic antibacterial agents of the present invention are shown below, but the invention is not limited thereto. (
Numbers in parentheses are BET surface area (m ² / g), particle size D 50% (μm), Zn or Cu content (wt%)
Represents (1) Formula (A-1) Zn _0.14 Mg _0.86 O (15, 0.5, 19.9) (A-2) Zn _0.05 Ca _0.95 O (12, 0.6, 19.9) (A-3 ) Cu _0.05 Ca _0.95 O (18, 0.2, 5.7) (A-4) Cu _0.14 Mg _0.86 O (30, 0.3, 19.4) (2) Formula (A-5) Zn _0.14 Mg _0.86 (OH) ₂ (19, 0.4, 19.6) (3) Formula (A-6) ZnO. (K ₂ O) _0.005 (120, 0.3, 80) (A-7) ZnO _{· (Na 2 O) 0.005 (} 90,0.3,80) (4) equation (A-8) ZnO · ( Al 2 O 3) 0.04 (30,0.4,76.5) (A- 9) antimicrobial agents having a modified surface of the a-8 with sodium laurate (30,0. 4,76.5) (a- 10) (CuO) · (Al 2 O 3) 2.5 · (SiO2) 40・ 12.5H ₂ O (15, 0.2, 2.3) (A-11) ZnO. (SiO ₂ ) _0.05 (25, 0.2, 77.5) (5) Formula (A-12) ZnO. (TiO ₂ ) _0.05 (15, 0.4, 76.6) (6) Formula (A-13) ZnO. (MgO) _1.5. (Al ₂ O ₃ ) _1.25 (60, 0.3, 24.3) Others (A-14) ZnO (30, 0.3, 80.3) (A-15) An antibacterial agent (30, 0.3, 80.30) obtained by modifying the surface of A-14 with sodium laurate. 3)

The inorganic antibacterial agent of the present invention is preferably surface-treated. The following is an example of one that is preferably used as the surface treatment agent. Higher fatty acids having 10 or more carbon atoms such as stearic acid, erucic acid, palmitic acid, lauric acid and behenic acid; alkali metal salts of the higher fatty acids; sulfuric acid ester salts of higher alcohols such as stearyl alcohol and oleyl call; polyethylene glycol ether Sulfate ester salt, amide bond sulfate ester salt, ester bond sulfate ester salt, ester bond sulfonate, amide bond sulfonate, ether bond sulfonate, ether bond alkylallyl sulfonate,
Anionic surfactants such as ester-bonded alkylallyl sulfonates and amide-bonded alkylallyl sulfonates; mono- or diesters of orthophosphoric acid and oleyl alcohol, stearyl alcohol, etc., or a mixture of both, and their acid form or Phosphates such as alkali metal salts or amine salts; vinylethoxysilane,
Vinyl-tris (2-methoxy-ethoxy) silane, gamma-methacryloxypropyltrimethoxysilane, gamma-aminopropyltrimethoxysilane, beta (3,4-epoxycyclohexyl) ethyltrimethoxysilane, gamma-glycidoxypropyltri Silane coupling agents such as methoxysilane and gamma-mercaptopropyltrimethoxysilane; isopropyltriisostearoyl titanate, isopropyl tris (dioctyl pyrophosphate) titanate, isopropyl tri (N-aminoethyl-aminoethyl) titanate,
Titanate coupling agents such as isopropyl tridecylbenzene sulfonyl titanate; aluminum coupling agents such as acetoalkoxyaluminum diisopropylate; esters of polyhydric alcohols and fatty acids such as glycerin monostearate and glycerin monooleate. Among these, among the surface treatment agents selected from the group consisting of higher fatty acids, anionic surfactants, phosphoric acid esters, coupling agents (silane-based, titanate-based, aluminum-based) and esters of polyhydric alcohols and fatty acids. Surface treatment with at least one of the above is preferable, and higher fatty acids having 10 or more carbon atoms such as stearic acid, erucic acid, palmitic acid, lauric acid, and behenic acid, and alkali metal salts of the higher fatty acids are particularly preferable. The surface treatment can be performed by a method similar to the method described in Example 1 of JP 2001-123071A.

The particle size D50% of the inorganic antibacterial agent of the present invention is preferably 0.05 to 20 μm, more preferably 0.05 to 10 μm, and further preferably 0.05 to 5 μm. The particle size is ultrasonically dispersed for 5 minutes or more,
It is the value measured by the laser scattering method. The BET surface area of antibacterial agents is an important indicator. Generally, an extremely large BET surface area is preferable in order to rapidly exert an antibacterial effect. However, on the other hand, in order to maintain the antibacterial effect, it is necessary to set the value below a certain level. Therefore, BET surface area is preferably 1~300m ² / g, more preferably 5~150m ² / g, more preferably 10 to 150 m ² / g. Methods for producing these inorganic antibacterial agents include JP-A-6-72816, JP-A-6-65011, and JP-A-8-
-291011, JP-A-8-48606, JP-A-1
1-123385, JP-A-11-180808, JP-A-11-209258, 2000-63219.
The method described in No. can be used.

The inorganic antibacterial agent of the present invention may be used alone, may be supported on a porous substance, and may be integrated with the porous substance by means such as sintering and adhesion. In any case, it is preferable to be molded (or granulated) into granules of 0.1 to 50 mm. Granule size is 0.
It is more preferably 5 to 30 mm, most preferably 1 to 15 mm. It is preferable that the particle size is large to some extent because it is less likely to be scattered by wind or the like. However, if the particle size is too large, the probability that the antibacterial agent will come into contact with the bacteria decreases, and the antibacterial effect decreases. That is,
The larger the particle size, the weaker the antibacterial effect, but the longer the antibacterial effect is. To maximize the antibacterial effect,
This particle size should be selected according to the purpose. The inorganic antibacterial agent may be used in the form of fine particles, granulated, or supported on a porous substance. Further, it may be formed into an appropriate shape by sintering or the like.

Further, it is preferable to use the inorganic antibacterial agent of the present invention and a porous substance (adsorbent) in combination. It is considered that this is because the porous substance adsorbs bacteria, harmful gas, etc., and the antibacterial agent beside it decomposes these bacteria, gas.

Preferred as the porous substance used in the present invention are carbonaceous materials such as activated carbon, charcoal, carbon nanotubes, silica gel, aerosil, white carbon, high silica clay, silica sol, porous glass, silica fiber, and silica. Soil, colloidal silica such as calcium silicate, natural zeolite, zeolite such as synthetic zeolite, activated alumina, alumina such as alumina, bone charcoal,
There are apatites such as natural apatite and synthetic apatite, fuller's earth, activated clay, activated bauxite, activated magnesium oxide, etc. These porous materials are described in "Science of Adsorption" (Seiichi Kondo, Maruzen Publishing Co., Ltd., February 2001), pp. 183-217, "Design of Adsorbent / Adsorption Operation".
(Hiroshi Yanai, Gihodo Publishing, published in January 1982) 48-
It is described on page 53. Among them, porous glass, zeolites such as natural zeolite, synthetic zeolite, slag,
Alumina such as activated alumina and alumina is preferable. Of these, zeolite and slag are most preferred. Further, those that do not change during high temperature firing are preferable.

The BET surface area of the porous material is 10 m 2 /
g or more, preferably 100 m2 / g or more, more preferably 200 m2 / g or more, 600 m2
/ G or more is most preferable. The average size of the porous material is preferably 0.01 to 100 μm, and 0.05 to 30 μm.
Is more preferable and 0.1 to 10 μm is most preferable.

These porous substances may be particles in any shape such as spherical shape and plate shape, and those formed by sintering into a certain size shape are preferable. When an antibacterial agent is supported on these porous materials, especially zeolite, it is disclosed in Japanese Patent Application Laid-Open No.
It can be carried out by a method according to Reference Example 1 of No. 246322. Also, JP-A-6-72816 and JP-A-6-6
No. 5011, JP-A-8-291011, JP-A-8-4
8606, JP-A-11-123385, JP-A-11-
In the method of the antibacterial agent described in JP-A-180808, JP-A-11-209258, and JP-A-2000-63219, it is also preferable to support the carrier by a method in which a carrier coexists during the synthesis.

The antibacterial agent of the present invention may be contained in a treatment instrument of a dental clinic, a treatment table, and the peripheral thereof, and is not particularly limited. It is used for the ceramic products of the treatment table and washing table of the dental clinic. Unlike organic antibacterial agents, high temperature treatment is possible, and unlike silver antibacterial agents, it is preferable because it is not deactivated by chlorine ions.

It can also be contained in the thermoplastic resin.
As the thermoplastic synthetic resin preferably used, for example, fluorine resin, acrylic resin, polyamide resin, vinyl chloride resin, polycarbonate resin, polyolefin resin, epoxy resin, polyacetal resin, polyester resin, polyetherimide resin, polyether sulfone resin, Examples include polyether ether ketone resin, polyphenylene sulfide resin, polysulfone resin, polyarylate resin, polyethylene naphthalate resin, polymethylpentene resin, ABS resin, vinyl acetate resin and polystyrene resin. It can also be contained in a thermosetting synthetic resin. For example, melamine resin, phenol resin, urea resin, furan resin, alkyd resin, unsaturated polyester resin, diallyl phthalate resin, epoxy resin, silicone resin, polyurethane resin, polyimide resin, polyparabanic acid resin, etc. may be mentioned. Natural polymer resins are also preferred

It can also be contained in the paint. As the coating material containing the antibacterial agent, amino-alkyd, vinyl, acrylic, epoxy, urethane, unsaturated polyester resin-based and emulsion-based coatings are preferable, and either water-based or organic-based coating may be used. A varnish containing no coloring material or a paint for imparting gloss may be used. However, when the inorganic antibacterial agent of the present invention is used, it is preferable to disperse it in an organic solvent. When it is used in an aqueous emulsion, it is preferable to disperse it in a hydrophobic component and then in water. The content is the nature of the binder,
Although it varies depending on the dispersed state, 0.3 to 5% by weight of solid content is preferable, and 1 to 4% is more preferable. It is also preferable to add the above resin or paint to the surface of the metal to apply it.

It is also preferable to incorporate it into fibers and use it around the treatment table. When the inorganic antibacterial agent of the present invention is added to the fiber, the fiber is a natural fiber (cotton, wool, silk, hemp,
Pulp), semi-synthetic fiber (rayon, cupra, acetate, etc.), synthetic fiber (polyester, polyurethane, polyvinyl acetal, polyamide, polyolefin, polyvinyl chloride, polyvinylidene chloride, polyacrylonitrile, polyfluorine, etc.), or inorganic Fibers (glass, ceramics, etc.) can be mentioned. To impart antibacterial properties to these fibers, a known method such as a method of contacting the fibers with the antibacterial agent of the present invention, followed by washing with water and drying, or a method of spraying the antibacterial agent of the present invention on the fibers is used. Can be adopted. Further, if the antibacterial agent of the present invention contains a surfactant, it is excellent in compatibility with the fiber, so after washing the final fiber product, the antibacterial agent is easily added by adding the antibacterial agent during rinsing. Can be granted.

It can also be contained in rubber. Examples include EPDM, SBR, NBR, butyl rubber, isoprene rubber, chlorosulfonated polyethylene and the like. Diene rubbers and hydrogenated products thereof (for example, NR, I
R, epoxidized natural rubber, SBR, BR (high cis BR and low cis BR), NBR, hydrogenated NBR, hydrogenated SB
R); olefin rubber (for example, ethylene propylene rubber (EPDM, EPM), maleic acid modified ethylene propylene rubber (M-EPM); IIR, isobutylene and aromatic vinyl or diene monomer copolymer; acrylic rubber (ACM) A halogen-containing rubber (for example, Br-II
R, CI-IIR, bromide of isobutylene paramethylstyrene copolymer (Br-IPMS); CR; hydrin rubber (CHR / CHC); chlorosulfonated polyethylene (CSM); chlorinated polyethylene (CM); maleic acid modified chlorine Polyethylene (M-CM)); Silicone rubber (for example, methyl vinyl silicone rubber, dimethyl silicone rubber, methylphenyl vinyl silicone rubber); Sulfur-containing rubber (for example, polysulfide rubber); Fluorine rubber (for example, vinylidene fluoride rubber, Fluorine-containing vinyl ether rubber, tetrafluoroethylene-propylene rubber, fluorine-containing silicon rubber, fluorine-containing phosphazene rubber); thermoplastic elastomer (for example, styrene elastomer, olefin elastomer, ester elastomer) , Urethane-based elastomers, polyamide-based elastomer) and the like can be illustrated, may be any of these blends. JP 2000-17
It is preferable to use the technique of No. 8452.

Specific examples of the present invention will be described below.

[Example 1] A sodium hypochlorite aqueous solution was added to one side of a container separated by a porous filter, and hydrochloric acid diluted with water was added to the other side. Adjusted to 5.7, effective chlorine concentration is 50pp
m of the hypochlorous acid aqueous solution of the present invention was prepared. The disinfectant was used to wash the inside of the oral cavity, and the cleaning waste liquid was drawn from the oral cavity by a suction method and discharged to the washstand of the treatment table. There is no chlorine odor, compared to disinfection with electrolyzed water (effective chlorine concentration is 50 ppm),
It was well received by medical staff. The number of bacteria in the oral cavity was examined by a bacterial culture method, and in all of the five examined cases, the number of bacteria was smaller than that of conventional electrolyzed water, which was preferable.

Example 2 Example 1 was repeated except that the pH was changed to 4.8 and 6.2, and similar results were obtained.

[Example 3] A treatment instrument for a dental clinic was sterilized with the disinfecting solution of the present invention prepared in the same manner as in Example 1. At the same time, Example 1
Disinfection with the electrolytic solution described was also tried. After all, the number of bacteria in the therapeutic device was examined by the bacterial culture method, and in all of the six cases examined, the number of bacteria was smaller than that of the conventional electrolyzed water, which was preferable.

Example 4 Example 3 was repeated except that the pH was changed to 4.8 and 6.2, and similar results were obtained.

Example 5 A polypropylene resin film containing 3% by weight of the antibacterial agent A-9 of the present invention was prepared by a kneading method using a three-roll mill (H5-1). Moreover, the film sample of the polypropylene resin which used A-11,8,1,6,14 instead of A-9 was created (H5-2.
6). Further, for comparison, a polypropylene resin film (C1-1) containing no antibacterial agent, and an organic antibacterial agent benzimidazole antibacterial agent 3 g on the surface of the film
/ M2 A polypropylene resin film (C1-2) coated with a gravure coater is prepared, and a polypropylene resin film (C1-3) containing a zeolite-containing silver antibacterial agent (3% by weight) is kneaded by a three-roll mill. Created by the method. These H5-1 to C6 and C1-1 to C3 were placed on a dental treatment table for 1 day, and the number of bacteria was measured by the culture method after treatment of 10 patients on the day. During treatment and before and after the treatment, the bactericidal solution of the hypochlorous acid-containing aqueous solution of the present invention was scattered on these polypropylene resin films. 1
The order in which the number of bacteria after the day was small and preferred was as follows. H5-1 <H5-2, 3,4 <5 <6 << C
It was 1-1,2,3. Sample H5-1 of the present invention
6 was more preferable than C1-1-3 of the comparative example because of its large bactericidal / antibacterial effect. In addition, even when an organic antibacterial agent or a silver antibacterial agent was contained, it was exactly the same as the case without the antibacterial agent.

[Example 6] 2 pp of sodium fluoride in the oral disinfectant solution
Example 1 was repeated except that m was included. It had the effect of reducing the odor in the patient's mouth and was preferred over those without the addition of sodium fluoride.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61P 1/02 A61P 31/02 31/02 31/04 31/04 A01N 59/08 A // A01N 59 / 08 A61C 19/00 JF term (reference) 4C052 AA01 AA20 LL01 4C058 AA13 AA28 BB07 DD11 DD14 JJ07 JJ08 4C086 AA01 HA24 MA01 MA02 MA03 MA04 MA05 MA06 MA17 MA57 NA05 ZA67 ZB35 4C089 AA01 BB01 CA02 CA10 A02 BA10 CA02 CA10 A02

Claims (6)

[Claims] 1. An effective chlorine concentration of 10 to 1000 ppm,
A sterilizing solution for a dental clinic, which is a hypochlorous acid-containing aqueous solution whose pH is adjusted to 2.0 to 8.0 by addition of an acid. 2. The pH of the sterilizing solution is hydrochloric acid, phosphoric acid, acetic acid,
The sterilizing solution for a dental clinic according to claim 1, which is adjusted with at least one acid of citric acid and tartaric acid. 3. The sterilizing solution for dental clinic according to claim 2, wherein the pH of the sterilizing solution is adjusted with hydrochloric acid. 4. The sterilizing solution for a dental clinic according to claim 1, which contains 0.1 to 50 ppm of fluorine ions. 5. A dental treatment instrument, a dental treatment table and its surroundings in a place where the sterilizing solution according to any one of claims 1 to 4 is used is M.
An antibacterial method for a dental clinic, comprising an inorganic antibacterial agent containing at least one kind of metal ions consisting of n, Fe, Co, Ni, Cu and Zn. 6. The antibacterial method for a dental clinic according to claim 5, wherein the inorganic antibacterial agent is an oxide and / or a hydroxide.