JP2003137727A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin care preparation having synergistically enhanced antioxidant effects, sufficiently exhibiting effects of an antioxidant ingredient by formulation of a small amount thereof and having excellent preventing actions on roughening and aging of the skin and preventing or ameliorating effects on formation of lipid peroxides, inflammation and roughening of the skin caused by production of active oxygen in the skin. SOLUTION: This skin care preparation is obtained by formulating an extract from a plant of the genus Kigelia DC. and an antioxidant ingredient such as carotenoids, flavonoids, tannins, gallic acid and its salts and esters, tocopherol and its derivatives, superoxide dismutase, thioredoxin, thioredoxin reductase, butylhydroxytoluene and butylhydroxyanisole in combination.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention has an excellent effect of preventing rough skin and aging of the skin, and has the effect of preventing or improving lipid peroxide generation due to active oxygen generation in the skin, and skin inflammation and rough skin. The present invention relates to a skin external preparation. More specifically, the present invention relates to a skin external preparation containing a sausage tree plant extract and one or more selected from antioxidant components.

[0002]

2. Description of the Related Art As the adverse effects of oxidative stress caused by ultraviolet rays and endogenous oxygen on the skin have been revealed, application of substances having an antioxidant effect to external preparations for skin has been investigated. Typical examples of these antioxidant substances include antioxidant vitamins such as vitamin Es and vitamin Cs.

However, the above-mentioned antioxidative vitamins are unstable to light and oxidants, and even the derivatives having improved stability do not have sufficient antioxidative activity, and therefore, they have been incorporated into a skin external preparation. In order to obtain a sufficiently effective effect, a considerably high concentration is required, and depending on the dosage form of the external preparation, formulation may be difficult due to solubility problems, or formulation stability may be adversely affected.

[0004]

[Problems to be Solved by the Invention] The antioxidative effect is synergistically enhanced, and the effect of antioxidative components is fully exerted by the addition of a small amount, and the effect of preventing rough skin and aging of the skin is excellent, and the active oxygen in the skin is active. The object was to obtain an external preparation for the skin, which has the effect of preventing or ameliorating the generation of lipid peroxide, the skin inflammation, and the rough skin caused by the generation.

[0005]

Means for Solving the Problems The present inventor has conducted research in view of the above-mentioned problems, and as a result, by blending an extract of a sausage tree plant and an antioxidant component with a skin external preparation, The present inventors have found that the antioxidant effect possessed is synergistically enhanced, and that the antioxidant effect can be sufficiently exerted with a small amount of compounding, and have completed the present invention.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described.

Sausage genus ( Kigeli) used in the present invention
a DC.) plant is an evergreen or deciduous tree dicotyledon belonging to the family Bignoniaceae , and about 10 species are distributed and planted in Africa. It is known that cosmetics containing an extract of a sausage tree plant exhibit a bust-up effect by tightening action (French Patent Application Publication No. 2759910), and this is used in combination with a plant extract having an estrogen-like action. It is also disclosed that the bust size can be increased and a farming effect can be obtained (International Patent Application Publication 2000-
002531).

In the present invention, there is no particular limitation as long as it is a sausage plant, but it is preferable to use sausage tree ( Kigelia africana (Lamk.) Benth.) Because it is easily available. Although various parts such as fruits, bark, seeds and leaves can be used, it is preferable to use fruits from the viewpoint of their effects.

In the present invention, the sausage genus plant is extracted raw or after being subjected to treatments such as shredding, drying and crushing. The extraction is performed by immersing it in an extraction solvent. It may be stirred or homogenized in an extraction solvent in order to improve the extraction efficiency. As the extraction temperature, it is appropriate to set the temperature to about 5 ° C. to a temperature not higher than the boiling point of the extraction solvent. The extraction time depends on the type of extraction solvent and the extraction temperature,
It is appropriate that the time is about 4 hours to 2 weeks.

As the extraction solvent, in addition to water, methanol,
Lower alcohols such as ethanol, propanol and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin, ethers such as ethyl ether and propyl ether, esters such as ethyl acetate and butyl acetate. It is possible to use polar organic solvents such as acetone, ketones such as ethyl methyl ketone, etc., and one kind or two or more kinds are selected from these and used. Alternatively, physiological saline, phosphate buffer, phosphate buffered saline, etc. may be used. The ratio of the plant and the solvent at the time of extraction is not particularly limited, but the solvent is preferably 0.1 to 1000 times by weight the amount of the plant 1, and particularly 0.5 to 100 times by weight in terms of extraction operation and efficiency.

The extract of a sausage tree plant with the above-mentioned solvent can be used as it is in the external preparation for skin according to the present invention, but the concentrated and dried product is redissolved in water or a polar solvent, or It may be used after purification treatment such as decolorization, deodorization, desalting or the like within a range not impairing the effects of the invention, or fractionation treatment by column chromatography. For storage, it can be used after being purified and then freeze-dried and dissolved in a solvent before use. Further, it may be used by being encapsulated in vesicles such as liposomes or microcapsules.

There is no particular limitation on the amount of the extract of the sausage plant belonging to the genus Sauscinaceae added to the external preparation for skin, but even if it is added in a too large amount, the effect does not change, and it is 0.01 to 1
It is preferably 0% by weight, more preferably 0.01 to 5% by weight.

The antioxidant component used in the present invention may be of any kind and source as long as it can be usually added to a skin external preparation. For example, carotenoids, flavonoids, tannins and gallic acid and salts thereof can be used. In addition, esters, tocopherols and their derivatives, superoxide dismutase, thioredoxin, thioredoxin reductase, butylhydroxytoluene, butylhydroxyanisole and the like are used.

The carotenoids used in the present invention, regardless of type or origin, are α-carotene, β-carotene,
γ-carotene, lycopene, cryptoxanthin, lutein (xanthophyll), zeaxanthin, rhodoxanthin, crocetin and the like are exemplified. Moreover, these carotenoids may be used as they are, but derivatives such as glycosides and esters may also be used.

The flavonoids used in the present invention, regardless of type or origin, include flavones, chrysin, primetin, apigenin, luteolin and other flavones and flavone glycosides, galangin, kaempferol, fisetin, quercetin, myricetin, Flavonol and flavonol glycosides such as rutin, isoflavone and isoflavone glycosides such as daidzein and genistein, flavanone,
Flavanone and flavanone glycosides such as pinocembrin, naringenin, sakuranetin, hesperetin, eriodictyol, and matisinol, flavanonol, pinobanksin, aromadendrin, fustin, taxifolin, flavanonol glycosides, chalcone, and the like. Chalcone and chalcone glycosides such as butein, chalcone cartamidine, pedicin and pedicinin, benzalcumalanone and benzalcumalanone glycosides such as benzalcumalanone, sulfuretin, leptocidin and auroidin, pelargonidin, cyanidin and delphinidin And the anthocyanin glycosides.

The tannins used in the present invention are tannic acids in a broad sense, which are present in many plants, especially bark of beech plants such as oak and oak, leaves of plants such as goby, nulde and sumac, and fruits of Kariroku. It is also called gallotannin or gallotannin acid. Tannins are a general term for these complex aromatic compounds having a large number of phenolic hydroxyl groups widely distributed in the plant kingdom. Phenols and phenolcarboxylic acids are obtained by alkali decomposition. In the present invention, these plant-derived tannins may be used as they are or after being purified, and artificially synthesized ones may also be used. In addition, gallic acid and its salts, which are the constituents of tannin, and its esters can also be used. Among these tannins,
Most preferably, Hamamelitannin contained in Hamamelis extract is used.

The tocopherol and its derivatives used in the present invention are not particularly limited, and α-tocopherol, β-tocopherol, γ-tocopherol, d-tocopherol, tocopherol acetate, DL-α-nicotinate.
Examples include tocopherol and DL-α-tocopherol succinate.

In the present invention, superoxide dismutase, thioredoxin, thioredoxin reductase, butylhydroxytoluene, butylhydroxyanisole and the like may be added as other antioxidant components.

In the present invention, one of the above antioxidant components may be used alone or two or more of them may be used in combination. Further, the amount of these antioxidant components to be added to the external preparation for skin depends on the antioxidant activity of each antioxidant component,
About 0.00001 to 5% by weight, preferably 0.000
1-5% by weight is suitable.

In the present invention, a skin external preparation containing a sausage tree plant extract and an antioxidant component can be provided, and the skin external preparation takes the form of a lotion, emulsion, cream, ointment, or the like. be able to. Furthermore,
Lotions such as flexible lotion, astringent lotion, lotion for cleaning, emollient cream, moisture cream, massage cream, cleansing cream, creams such as makeup cream, emollient emulsion,
It can also be provided as cosmetics in various formulations such as moisture emulsions, nourishing emulsions, cleansing emulsions, jelly-like packs, peel-off packs, wash-off packs, powder packs and other packs, beauty essences, and facial cleansers. it can.

In the present invention, other active ingredients such as a cell activating agent, a whitening ingredient, a moisturizing agent, an anti-inflammatory agent and an ultraviolet absorber can also be used in combination, and a sunscreen cosmetic, an antiaging cosmetic, It can also be provided as a cosmeceutical such as a whitening agent or a quasi drug.

[0022]

EXAMPLES The features of the present invention will be described in more detail with reference to examples. First, a preparation example of a sausage plant extract used in the present invention is shown.

[Sausage tree extract] Fruit 50 of sausage tree ( Kigelia africana (Lamk.) Benth.)
0 g was pulverized, immersed in 5000 g of a 50 wt% ethanol aqueous solution, and subjected to stirring extraction at 25 ° C. for 24 hours. The extract was filtered and the filtrate was collected and sterilized with a Millipore filter to obtain a sausage plant extract.

The characteristics of the present invention will be described in detail by way of examples using an extract of a sausage genus plant. First, the antioxidant components and the sausage tree plant extract are shown in Table 1.
The skin cream was prepared according to the following formulation and prepared as Examples 1 to 4 and Comparative Examples 1 to 6.

Examples 1 to 4, Comparative Examples 1 to 6 Skin Cream (1) Beeswax 6.0 (wt%) (2) Cetanol 5.0 (3) Reduced Lanolin 8.0 ( 4) squalane 37.5 (5) fatty acid glycerin 4.0 (6) lipophilic glyceryl monostearate 2.0 (7) polyoxyethylene (20EO) sorbitan monolaurate 2.0 (8) propylene glycol 5. 0 (9) Methyl parahydroxybenzoate 0.1 (10) Purified water Amount based on 100 (11) Ingredients shown in Table 1 (12) Perfume 0.2 Manufacturing method: (1) to (7) The oil phase components of are mixed and dissolved to make uniform, and heated to 75 ° C. On the other hand, the water phase components (8) to (10) are mixed, dissolved and heated to 75 ° C. Next, the oil phase component is added to the above aqueous phase component to carry out preliminary emulsification, and then uniformly emulsified with a homomixer. After that, cool down at 50 ℃ (11),
Add (12) and mix.

[0026]

[Table 1]

Using Examples 1 to 4 and Comparative Examples 1 to 6, the effect of preventing the generation of wrinkles due to ultraviolet rays was evaluated. The evaluation of the wrinkle prevention effect was carried out by treating 5 hairless mice as one group, and applying an example and a comparative example to the back once a day for each group, and applying 1 J / cm ² / week of long wavelength ultraviolet light (UVA). Irradiation was carried out for 50 weeks, and the occurrence of wrinkles in hairless mice was observed, and scored according to the criteria shown in Table 2. At this time, a group to which only purified water was applied served as a control. The results are shown in Table 3 by calculating the average value of each group and the relationship with the number of UVA irradiation days.

[0028]

[Table 2]

[0029]

[Table 3]

As shown in Table 3, as compared with Comparative Examples 1 to 5 in which various components were blended alone, or Comparative Example 6 in which various components were not blended, the sausage tree plant extract and the antioxidant component were compared. In the examples of the present invention, which were used in combination, the wrinkles were remarkably suppressed and the minute wrinkles were slightly generated after 50 weeks, even though the amounts of the respective components were small.

Next, a practical use test for 6 months was conducted on Examples 1 to 4 and Comparative Examples 1 to 6 of the present invention. As panelists, women in their 40's to 60's who have skin symptoms such as remarkable wrinkles or decreased elasticity, and women in their 20's to 50's who have remarkable skin irritation symptoms, each group 20 people And The use test was carried out by allowing each group to use each of the example and the comparative example blindly and observing the skin condition before the start of the use test and after the end of the use test. Each of the improvement states of wrinkles and skin elasticity was evaluated in three stages of “improvement”, “slight improvement” and “no change”, and the number of panelists who obtained each evaluation is shown in Table 4.
The degree of wrinkles was evaluated by taking photographs and replicas, and the skin elasticity was evaluated by measuring with a cute meter. Regarding skin roughness, the skin condition was scored according to the criteria shown in Table 5, and the average value of 20 persons was used to compare before use test start and after use test end.
It was shown to.

[0032]

[Table 4]

As shown in Table 4, in the groups used in the examples of the present invention, no panelists showed no improvement in wrinkles and skin elasticity, and a clear improvement was observed in 16 or more panelists. On the other hand, in the use groups of Comparative Examples 1 to 5, wrinkles and elasticity were tended to be improved, but the number of panelists who showed a clear improvement was 10 or less.

[0034]

[Table 5]

[0035]

[Table 6]

As shown in Table 6, in the groups used in Examples of the present invention, all the panelists showed an improvement tendency of rough skin, and most of the panelists were able to clearly see the sulcus and the cuticle. . On the other hand, in Comparative Examples 1 to 5 in which various components were blended alone, the skin condition was improved as compared with Comparative Example 6 in which various components were not blended, but the skin groove was flat, and The shape remained unclear.

In Examples 1 to 4 of the present invention, no change in the preparation state such as precipitation, separation, aggregation, discoloration or discoloration of the contained components was observed during the use test period. In addition, in each of the groups used in each Example, no panelists showed skin irritation reaction or skin sensitization reaction.

Next, the formulation of another embodiment of the present invention will be shown.

[0039] [Example 5] Tonic agent for hair (1) Purified water 30.0 (wt%) (2) Ethanol 69.0 (3) Sausage tree plant extract 0.5 (4) Butylhydroxytoluene 0.5 Manufacturing method: Components (1) to (4) are mixed and homogenized.

Example 6 Skin Emulsion (1) Squalane 5.0 (wt%) (2) White Vaseline 2.0 (3) Beeswax 0.5 (4) Sorbitan sesquioleate 0.8 (5) Polyoxyethylene oleyl ether (20EO) 1.2 (6) Lycopene 0.2 (7) Methyl paraoxybenzoate 0.1 (8) Propylene glycol 5.0 (9) Purified water 59.4 (10) Carboxyvinyl polymer (1 wt% aqueous solution) 20.0 (11) Potassium hydroxide 0.1 (12) Sausage plant extract 0.5 (13) Ethanol 5.0 (14) Perfume 0.2 Manufacturing method: (1) ~ The oil phase components of (6) are mixed and heated to 75 ° C. to dissolve and homogenize. On the other hand, the water phase components (7) to (9) are mixed and dissolved and heated to 75 ° C., and the above oil phase components are added to carry out preliminary emulsification. After adding (10), homogenize with a homomixer, and add (11) to adjust the pH. 40 after cooling
Add (12) to (14) at ℃ and mix.

[0041] Example 7 Skin lotion (1) Ethanol 10.0 (wt%) (2) Hydroxyethyl cellulose 1.0 (3) Sausage tree plant extract 0.5 (4) Methyl paraoxybenzoate 0.1 (5) Glycerin 5.0 (6) Hamamelitannin 0.02 (7) Purified water 83.38 Manufacturing method: (1) to (7) are mixed to make uniform.

Example 8 Skin Emulsion (1) Stearic Acid 0.2 (wt%) (2) Cetanol 1.5 (3) Vaseline 3.0 (4) Liquid Paraffin 7.0 (5) Polyoxy Ethylene (10EO) monooleate 1.5 (6) Soybean-derived isoflavone 0.5 (7) Glycerin 5.0 (8) Methyl paraoxybenzoate 0.1 (9) Triethanolamine 1.0 (10) Purification Water 79.2 (11) Sausage tree plant extract 1.0 Manufacturing method: The oil phase components of (1) to (6) are mixed and heated to uniformly dissolve, and kept at 70 ° C. On the other hand, the water phase components (7) to (10) are mixed and heated to homogenize the mixture to 70 ° C. The oil phase component is gradually added to this water phase component while stirring to emulsify, and after cooling, the component (11) is added and mixed at 40 ° C.

[Example 9] Gel for skin (1) Purified water 92.8 (% by weight) (2) Carboxyvinyl polymer 0.5 (3) Dipropylene glycol 5.0 (4) Methyl paraoxybenzoate 0 1 (5) dl-α-tocopherol 2-L-ascorbic acid phosphoric acid diester 0.5 (6) potassium hydroxide 0.1 (7) sausage plant extract 1.0 Production method: (1) ( After evenly dissolving 2), add (4) and (3) to (3)
(5) is dissolved and added, then (6) is added to increase the viscosity,
Add the component (7).

Example 10 Skin Cream (1) Beeswax 6.0 (wt%) (2) Cetanol 5.0 (3) Reduced Lanolin 8.0 (4) Squalane 29.5 (5) Lipophilic Type Glycerin monostearate 4.0 (6) Polyoxyethylene (20EO) sorbitan monolaurate 5.0 (7) Propylene glycol 5.0 (8) Methyl paraoxybenzoate 0.1 (9) Purified water 36.2 (10) Sausage genus plant extract 1.0 (11) α-glucosylrutin 0.2 Production method: The oil phase components of (1) to (6) are mixed, dissolved and heated to 75 ° C. On the other hand, the aqueous phase components (7) to (9) are mixed, dissolved and heated to 75 ° C. Next, the oil phase component is added to the above aqueous phase component for preliminary emulsification, then it is uniformly emulsified with a homomixer, and after cooling, the components (10) and (11) are added and mixed at 40 ° C.

Example 11 Oil-in-Water Emulsion Ointment (1) White Vaseline 25.0 (wt%) (2) Stearyl Alcohol 25.0 (3) d-δ-Tocopherol 0.1 (4) Glycerin 10 0.0 (5) Sodium lauryl sulfate 1.0 (6) Methyl paraoxybenzoate 0.1 (7) Purified water 37.8 (8) Sausage plant extract 1.0 Manufacturing method: (1) to (3) The oil phase components of are mixed and dissolved to make uniform, and heated to 75 ° C. On the other hand, (4) to (7) are uniformly dissolved and heated to 75 ° C., the oil phase component is added thereto to emulsify, and after cooling, (8) is added and mixed at 40 ° C.

[Example 12] Lotion (1) Ethanol 10.0 (wt%) (2) 1,3-Butylene glycol 10.0 (3) Sausage plant extract 0.5 (4) Galactosyl flavone 0.5 (5) Perfume 0.1 (6) Purified water 78.9 Production method: (1) to (5) are sequentially added to (6) and uniformly mixed and dissolved.

[Example 13] Water-in-oil emulsified emollient cream (1) Liquid paraffin 30.0 (wt%) (2) Microcrystalline wax 2.0 (3) Vaseline 5.0 (4) Diglycerin oleic acid Ester 5.0 (5) L-Glutamic acid sodium 1.6 (6) L-serine 0.4 (7) Propylene glycol 3.0 (8) Methyl paraoxybenzoate 0.1 (9) Purified water 51.3 ( 10) Fragrance 0.1 (11) Sausage tree plant extract 0.5 (12) Gallic acid methyl ester 1.0 Manufacturing method: (5), (6) are dissolved in a part of (9) to 50 ° C. age,
Gradually add to (4) heated to 50 ° C. with stirring.
This was mixed in advance and dissolved by heating at 70 ° C (1) ~
Disperse evenly in (3), add (7) and (8) to the rest of (9) and heat to 70 ° C. with stirring,
Emulsify with a homomixer. After cooling, at 40 ℃ (10) ~
Add (12) and mix.

[Example 14] Makeup base cream (1) Stearic acid 12.0 (% by weight) (2) Cetanol 2.0 (3) Glycerin tri-2-ethylhexanoate 2.5 (4) Self Emulsified glycerin monostearate 2.0 (5) Kuzukon-derived isoflavone 0.5 (6) Propylene glycol 10.0 (7) Potassium hydroxide 0.3 (8) Purified water 68.1 (9) Titanium oxide 1 0 (10) Red iron oxide 0.1 (11) Yellow iron oxide 0.4 (12) Perfume 0.1 (13) Sausage genus plant extract 1.0 Manufacturing method: Oil phase components of (1) to (5) Are mixed and heated to 75 ° C. to homogenize. On the other hand, by mixing the water phase components (6) to (8),
It is heated to 75 ° C. and melted to make it uniform, and the pigments (9) to (11) are added thereto and dispersed uniformly by a homomixer. The oil phase component is added to the aqueous phase component, the mixture is emulsified by a homomixer and then cooled, and the components (12) and (13) are added and mixed at 40 ° C.

Example 15 Milky liquid foundation (1) Stearic acid 2.0 (wt%) (2) Squalane 5.0 (3) Octyldodecyl myristate 5.0 (4) Cetanol 1.0 (5) Decaglycerin monoisopalmitate 9.0 (6) Lycopene 0.5 (7) 1,3-butylene glycol 8.0 (8) Potassium hydroxide 0.1 (9) Methyl paraoxybenzoate 0.1 (10 ) Purified water 50.6 (11) Titanium oxide 9.0 (12) Talc 7.4 (13) Red iron oxide 0.5 (14) Yellow iron oxide 1.1 (15) Black iron oxide 0.1 (16) Perfume 0.1 (17) Sausage tree plant extract 0.5 Production method: Mix the oil phase components of (1) to (6) and heat to 75 ° C. to homogenize. On the other hand, by mixing the water phase components (7) to (10),
Heat to 75 ° C to dissolve and homogenize, add the pigments of (11) to (15) to this, homogenize with a homomixer, and then cool, and cool to 40 ° C at (16) and (17). Add and mix the ingredients.

Example 16 Hand Cream (1) Cetanol 4.0 (wt%) (2) Vaseline 2.0 (3) Liquid Paraffin 10.0 (4) Glycerin Monostearate 1.5 (5) Polyoxyethylene (60EO) glycerin isostearic acid ester 2.5 (6) Tocopherol acetate 0.5 (7) Glycerin 20.0 (8) Methyl paraoxybenzoate 0.1 (9) Purified water 57.4 (10) Sausage Cypress plant extract 1.0 (11) Hamamelitannin 1.0 Manufacturing method: The oil phase components of (1) to (6) are mixed, dissolved and heated to 75 ° C. On the other hand, the aqueous phase components (7) to (9) are mixed, dissolved and heated to 75 ° C. Next, the oil phase component is added to the aqueous phase component to pre-emulsify it, then the mixture is uniformly emulsified with a homomixer and cooled, and the components (10) and (11) are added and mixed at 40 ° C.

[0051]

EFFECTS OF THE INVENTION The external preparation for skin of the present invention comprising a combination of a sausage tree plant extract and an antioxidant component is excellent in the effects of preventing rough skin and aging of the skin, and is capable of removing lipid peroxides resulting from the generation of active oxygen in the skin. It has the effect of preventing or improving the generation, inflammation of the skin and rough skin.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/48 A61K 7/48 31/015 31/015 31/05 31/05 31/085 31/085 31 / 192 31/192 31/352 31/352 31/355 31/355 31/7024 31/7024 35/78 35/78 C W A61P 17/00 A61P 17/00 17/16 17/16 39/06 39 / 06 43/00 105 43/00 105 F term (reference) 4C083 AA082 AA111 AA112 AB032 AB232 AB242 AB432 AC012 AC022 AC072 AC102 AC122 AC182 AC242 AC352 AC402 AC422 AC442 AC471 AC472 AC482 AC542 AC582 AC782 AC841 AC842 AD042 AD092 AD282 AD512 AD412 AD392 AD412 AD392 AD412 AD392 AD412 AD392 AD4621 AD642 AD661 AD662 BB47 CC02 CC03 CC04 CC05 CC12 CC33 DD22 DD23 DD27 DD31 DD41 EE05 EE12 EE13 FF05 4C086 AA01 AA02 BA08 BA09 MA02 MA04 MA63 NA14 ZA89 ZA92 ZB21 ZC41 CA06 CA14 CA14 CA14 CA14 CA14 CA14 CA14 CA14 BA14 BA08 BA09 BA08 BA09 BA08 BA09 BA08 BA09 BA14 ZA 92 ZB21 ZC41 ZC75 4C206 AA01 AA02 BA04 CA17 CA27 KA01 MA02 MA04 MA83 NA14 ZA89 ZA92 ZB21 ZC41 ZC75

Claims (3)

[Claims] 1. A skin external preparation containing a sausage tree ( Kigelia DC.) Plant extract and one or more components selected from antioxidant components. 2. Antioxidant components are carotenoids, flavonoids, tannins, gallic acid and its salts, and esters, tocopherol and its derivatives, superoxide dismutase, thioredoxin, thioredoxin reductase, butylhydroxytoluene, butylhydroxyanisole. The external preparation for skin according to claim 1, which is one kind or two or more kinds selected from the following. 3. A sausage tree ( Kigelia DC.) Plant is a sausage tree ( Kigelia africana (Lamk.) Bent.
The external preparation for skin according to claim 1 or 2, which is h.).