JP2003126106A - Tissue collection needle - Google Patents
Tissue collection needleInfo
- Publication number
- JP2003126106A JP2003126106A JP2001331311A JP2001331311A JP2003126106A JP 2003126106 A JP2003126106 A JP 2003126106A JP 2001331311 A JP2001331311 A JP 2001331311A JP 2001331311 A JP2001331311 A JP 2001331311A JP 2003126106 A JP2003126106 A JP 2003126106A
- Authority
- JP
- Japan
- Prior art keywords
- needle
- inner tube
- outer needle
- hollow
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Surgical Instruments (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
【０００１】[0001]
【発明が属する技術分野】本発明はヒト並びに動物の組
織を採取する針に関し、さらに詳細には、体外受精なら
びに顕微受精を行うために、ヒト並びに動物の体内の卵
巣から卵子を吸引採取するために使用する組織採取針に
関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a needle for collecting human and animal tissues, and more particularly, for aspirating and collecting eggs from ovaries in humans and animals for in vitro fertilization and microfertilization. A tissue sampling needle used for.
【０００２】[0002]
【従来の技術】ヒトまたは動物の卵巣から卵子を採取す
るに当たって、一般的には、経膣用超音波プローブに組
織採取針をセットして、超音波エコー下に膣から組織採
取針を穿刺し、卵巣に組織採取針を到達させる。卵巣内
に洗浄液を注入して、該卵巣中の卵胞を吸引して卵子を
採取する。組織採取針には、超音波を反射するエコーガ
イドが組織採取針の先端部に設けられている。このよう
な組織採取針には、シングルニードルの超音波組織採取
針を卵巣に穿刺し、シリンジで洗浄液を注入し、その
後、別のシリンジで卵子を採取する操作を繰り返すもの
がある。しかし、この方法は１つのシリンジを別なシリ
ンジに差し替える操作の間に、刃先が振れたり、洗浄液
の逆流あるいは漏出がおこるために、卵子の採取に時間
がかかり、また、卵子の採取率も低いとの欠点を有して
いた。その後、２つのルーメンを有するダブルルーメン
組織採取針が開発され、術者が卵巣を穿刺して卵胞の卵
子を確認し、補助者がシリンジにて洗浄液を注入しなが
ら、吸引器を用いて同時に吸引を行うことが可能となっ
た。このような２つのルーメンを有する組織採取針を用
いた方法において、採卵時間および採卵率は向上するこ
とが可能となった。2. Description of the Related Art Generally, when collecting an egg from an ovary of a human or an animal, a tissue collecting needle is set on a transvaginal ultrasonic probe, and the tissue collecting needle is punctured from the vagina under ultrasonic echo. , Reach the ovary with a tissue collection needle. A washing solution is injected into the ovary, and the follicle in the ovary is aspirated to collect an egg. An echo guide that reflects ultrasonic waves is provided on the tip of the tissue sampling needle. As such a tissue collecting needle, there is one in which an operation of puncturing an ovary with a single-needle ultrasonic tissue collecting needle, injecting a washing solution with a syringe, and then collecting an egg with another syringe is repeated. However, this method takes a long time to collect an egg because the blade tip shakes or the wash liquid flows back or leaks during the operation of replacing one syringe with another, and the egg collection rate is also low. And had the drawbacks. After that, a double-lumen tissue sampling needle with two lumens was developed, and the operator punctured the ovary to confirm the ovary of the follicle, and the assistant simultaneously injects the washing solution with a syringe and simultaneously aspirates using an aspirator. It became possible to do. In the method using such a tissue-collecting needle having two lumens, the egg collection time and the egg collection rate can be improved.
【０００３】[0003]
【発明が解決しようとする課題】しかしながら、従来の
ダブルルーメン針では、洗浄液の注入口と卵子の吸引口
が同一刃面上もしくは刃面内側に存在するため、洗浄と
吸引を同時に行った際には、洗浄液を十分多量に注入し
ないと、洗浄液が卵胞内に注入する前に全て吸引される
ことになり、補助者は勢いよく洗浄液を注入しなければ
ならなかった。However, in the conventional double-lumen needle, since the injection port for the cleaning liquid and the suction port for the ovum are on the same blade surface or inside the blade surface, when cleaning and suction are performed at the same time. If the wash solution was not injected in a sufficiently large amount, the wash solution would be completely aspirated before being injected into the follicle, and the assistant had to inject the wash solution vigorously.
【０００４】[0004]
【課題を解決するための手段】本発明者らは、上記課題
を解決するために、鋭意検討したところ、金属外針と内
管を二重構造とし、内管を水分の変化（通常の湿度条件
から洗浄液および体液の存在する条件への変化）および
／あるいは温度の変化（室温から体温）により寸法変形
する材料を採用することにより、卵巣へ組織採取針を穿
刺した後、洗浄液から該内管が水分を吸収して、または
温度変化により変形し、かつ伸長して、穿刺した金属外
針の刃面から突出した内管から組織を吸引することによ
り、洗浄液注入口と組織吸引口の位置が離れて、洗浄液
を直接に吸引することを防ぐことを見出し、本発明に到
達した。Means for Solving the Problems The inventors of the present invention have made extensive studies in order to solve the above-mentioned problems. After puncturing the ovary with a tissue-collecting needle by adopting a material that undergoes dimensional deformation due to changes from conditions to conditions in which washing liquid and body fluid exist and / or changes in temperature (room temperature to body temperature), the internal tube is washed from the washing liquid. Absorbs water, or deforms due to temperature change and expands, and sucks the tissue from the inner tube protruding from the blade surface of the punctured metal outer needle, so that the positions of the irrigation fluid injection port and the tissue suction port are changed. The present inventors have arrived at the present invention by finding that they prevent direct suction of the cleaning liquid.
【０００５】すなわち、本発明は先端に刃先が設けられ
た中空金属外針と、該外針に内装された中空内管と、該
外針および該内管の基端部をそれぞれ固定する手段を備
えた分岐コネクターとからなり、該内管が伸長すること
により、内管先端部が該外針刃面より前方に突出するこ
とを特徴とする組織採取針である。That is, the present invention provides a hollow metal outer needle having a cutting edge at its tip, a hollow inner tube inside the outer needle, and means for fixing the outer needle and the proximal end of the inner tube, respectively. A tissue sampling needle comprising a branch connector provided, wherein the inner tube tip portion protrudes forward from the outer needle blade surface when the inner tube extends.
【０００６】また、本発明は先端に刃先が設けられた中
空金属外針と、該外針に内装された中空内管と、該外針
および該内管の基端部をそれぞれ固定する手段を備えた
分岐コネクターとからなり、前記中空金属外針と前記中
空内管との間に空隙が形成され、かつ、該空隙は金属外
針基端部の分岐コネクターにより中空金属外針および中
空内管の軸方向から側方に開放された液注入ルートおよ
び前記外針刃面より内側に開口部を有し、かつ、外針針
基の分岐コネクターの内部を通過する組織吸引ルートを
形成し、前記内管が伸長することにより、内管先端部が
該外針刃面より前方に突出することを特徴とする組織採
取針である。Further, the present invention provides a hollow metal outer needle having a cutting edge at the tip, a hollow inner tube inside the outer needle, and means for fixing the outer needle and the proximal end of the inner tube, respectively. A branch connector provided with the hollow metal outer needle and the hollow inner tube, and a space is formed between the hollow metal outer needle and the hollow inner tube, and the space is formed by a branch connector at the base end of the metal outer needle. A liquid injection route that is opened laterally from the axial direction and an opening portion inside the outer needle blade surface, and forms a tissue suction route that passes through the inside of the branch connector of the outer needle needle base, The tissue sampling needle is characterized in that when the inner tube extends, the tip of the inner tube projects forward from the outer needle blade surface.
【０００７】[0007]
【発明の実施の態様】本発明における組織採取針とは、
先端に刃先が設けられた中空金属外針と、該外針に内装
された中空内管と、該外針および該内管の基端部をそれ
ぞれ固定する手段を備えた分岐コネクターとからなる。
中空金属外針とは、その外形は内部が連通する管状体で
あり、その先端部には刃先が設けられている。その刃先
形状は、通常、先端が鋭利な刃面である。外径、内径お
よび長さは特に制限されないが、通常、外径は、０．５
〜２．５ｍｍ、好ましくは１．４〜１．８ｍｍであり、
内径は０．３〜２．２ｍｍ、好ましくは１．０〜１．６
ｍｍであり、長さは通常、５０〜４５０ｍｍ、好ましく
は２００〜４００ｍｍである。これらの外径、内径また
は長さはその使用目的に応じて、適宜選択される。金属
としては、ステンレス、チタン、ニッケルチタン合金な
どが挙げられる。外針には超音波エコーを反射するエコ
ーガイドがその先端に設けられていることが好ましい。BEST MODE FOR CARRYING OUT THE INVENTION The tissue sampling needle of the present invention is
It is composed of a hollow metal outer needle having a cutting edge at its tip, a hollow inner tube inside the outer needle, and a branch connector equipped with means for fixing the outer needle and the proximal end of the inner tube.
The outer hollow metal needle is a tubular body whose inside communicates with the inside thereof, and has a cutting edge at its tip. The shape of the cutting edge is usually a blade surface with a sharp tip. The outer diameter, inner diameter and length are not particularly limited, but normally the outer diameter is 0.5
~ 2.5 mm, preferably 1.4-1.8 mm,
Inner diameter is 0.3-2.2 mm, preferably 1.0-1.6
mm, and the length is usually 50 to 450 mm, preferably 200 to 400 mm. These outer diameter, inner diameter or length are appropriately selected depending on the purpose of use. Examples of the metal include stainless steel, titanium, nickel titanium alloy and the like. The outer needle is preferably provided with an echo guide for reflecting ultrasonic echoes at its tip.
【０００８】本発明における内管とは、該外針に内装さ
れた中空内管である。内管と外針との長さは、使用前に
は前者が後者と同じまたはより短いことが必須である。
該外針および該内管の基端部はそれぞれを固定する手
段を備えた分岐コネクターに連結される。前記中空金属
外針と前記中空内管との間に空隙が形成され、かつ、該
空隙は金属外針基端部の分岐コネクターにより中空金属
外針および中空内管の軸方向から側方に開放された液注
入ルートおよび前記外針刃面より内側に開口部を有し、
かつ、外針針基の分岐コネクターの内部を通過する組織
吸引ルートを形成する。本発明では、前記内管が伸長す
ることにより、内管先端部が該外針刃面より前方に突出
することを特徴とする。The inner tube in the present invention is a hollow inner tube incorporated in the outer needle. The lengths of the inner tube and the outer needle must be the same or shorter than the latter before use.
The proximal ends of the outer needle and the inner tube are connected to a branch connector provided with means for fixing each. A void is formed between the hollow metal outer needle and the hollow inner pipe, and the void is opened laterally from the axial direction of the hollow metal outer needle and the hollow inner pipe by a branch connector at the base end of the metal outer needle. Has an opening inside the liquid injection route and the outer needle blade surface,
In addition, a tissue suction route that passes through the inside of the branch connector of the outer needle base is formed. The present invention is characterized in that the inner tube extends so that the tip of the inner tube projects forward from the outer needle blade surface.
【０００９】前記中空の内管は、水分または温度の変化
により伸長する材料からなる。このような材料としては
吸水性合成樹脂または形状記憶合金がある。吸水性樹脂
としては、ポリウレタン、ナイロン、エチレン・酢酸ビ
ニル共重合体（ＥＶＡ）、ポリビニルアルコール（ＰＶ
Ａ）、エチレン・ビニルアルコール共重合体（EＶOH）な
どの吸水性樹脂などが例示される。 また、形状記憶合
金としては、Ni-Ti、Ni-Ti-Co、In-Tl、Fe-Mn、Fe-Ni-T
i-Coなどの合金が例示される。これらの材料のうち、吸
水性樹脂としては、具体的には、室温（約２０℃）で湿
度５０％の環境から、体温（約３６℃）で湿度１００％
の環境の変化において、０．１〜３０％の形状変化をも
たらす樹脂が好ましい。ここで、このような温度および
湿度の変化において、材料の含水率は、０．５％〜４０
％へ変化しているものと推定される。また、別な材料と
しては、３７℃付近にＡＦ点（オーステナイト逆終了変
態点）を設定された形状記憶合金が好ましい。さらに、
本発明の内管は吸水性合成樹脂または形状記憶合金から
形成された管と金属管とを接続した構造を有していても
よい。また、吸水性合成樹脂または形状記憶合金から形
成された管と他の合成樹脂から形成された管とを接続し
た構造を有していてもよい。先端部分は形状変化をもた
らす樹脂であることが好ましい。The hollow inner tube is made of a material that expands when moisture or temperature changes. Examples of such a material include water-absorbing synthetic resin and shape memory alloy. As the water absorbent resin, polyurethane, nylon, ethylene / vinyl acetate copolymer (EVA), polyvinyl alcohol (PV
A) and water-absorbent resins such as ethylene / vinyl alcohol copolymer (EVOH) are exemplified. Further, as the shape memory alloy, Ni-Ti, Ni-Ti-Co, In-Tl, Fe-Mn, Fe-Ni-T
An alloy such as i-Co is exemplified. Among these materials, as the water-absorbent resin, specifically, from an environment of 50% humidity at room temperature (about 20 ° C), 100% humidity at body temperature (about 36 ° C).
A resin that causes a shape change of 0.1 to 30% in the change of the environment is preferable. Here, in such changes in temperature and humidity, the water content of the material is 0.5% to 40%.
It is estimated that it has changed to%. Further, as another material, a shape memory alloy having an AF point (austenite reverse termination transformation point) around 37 ° C. is preferable. further,
The inner tube of the present invention may have a structure in which a tube made of a water-absorbent synthetic resin or a shape memory alloy and a metal tube are connected. Further, it may have a structure in which a tube made of a water absorbent synthetic resin or a shape memory alloy and a tube made of another synthetic resin are connected. The tip portion is preferably a resin that causes a shape change.
【００１０】本発明における分岐コネクターとは、該外
針の基端部と該外針に内挿された内管の基端部をそれぞ
れ固定するものである。このような分岐コネクターは、
下記洗浄液注入ルートおよび組織吸引ルートを形成され
るものである。The branch connector in the present invention is for fixing the base end portion of the outer needle and the base end portion of the inner tube inserted into the outer needle, respectively. Such a branch connector is
The following washing solution injection route and tissue suction route are formed.
【００１１】前記中空金属外針と前記中空内管との間に
は空隙が形成されている。該空隙は金属外針基端部の分
岐コネクターにより中空金属外針および中空内管の軸方
向から側方に開放された液注入ルートおよび前記外針刃
面より内側に開口部を有し、かつ、外針針基の分岐コネ
クターの内部を通過する組織吸引ルートを形成する。A void is formed between the hollow metal outer needle and the hollow inner tube. The void has a liquid injection route opened laterally from the axial direction of the hollow metal outer needle and the hollow inner tube by a branch connector at the base end of the metal outer needle, and an opening portion inside the outer needle blade surface, and Forming a tissue suction route that passes through the inside of the branch connector of the outer needle base.
【００１２】上記液注入ルートには、洗浄液を注入する
ための洗浄ラインチューブのルアーコネクターが接続さ
れる。また、上記組織吸引ルートには、採取された組織
を貯留するための試験管の接続された吸引ラインチュー
ブのルアーコネクターが接続されている。洗浄操作は、
シリンジにヘパリン化生食や培養液が充填され、洗浄液
として、ルアーコネクターから直接もしくは延長チュー
ブを介して注入される。また、吸引操作は接続された試
験管付きの吸引ラインへ、吸引器を接続し断続的に空気
を陰圧に吸引する事により試験管内への組織の採取を行
う。A luer connector of a cleaning line tube for injecting a cleaning liquid is connected to the liquid injection route. The luer connector of the suction line tube to which the test tube for storing the collected tissue is connected is connected to the tissue suction route. The cleaning operation is
A syringe is filled with heparinized saline or a culture solution and injected as a washing solution directly from a luer connector or via an extension tube. Further, in the suction operation, a suction device is connected to the suction line with the connected test tube to intermittently suck air to a negative pressure to collect the tissue in the test tube.
【００１３】本発明の組織採取針を使用するに当たっ
て、まず、膣を経由して、該採取針を卵巣へ輸送し、目
的部位にて中空金属外針刃面先端を穿刺する。次いで、
水分または温度の変化によって内管形状を変化させて、
前記外針先端より前方へ内管先端を伸長させる。次い
で、あるいは同時に液注入ルートを経由して外針と内針
の間の空隙から洗浄水を送水する。洗浄液とともに卵子
を内管の中空部から吸引して、組織採取ルートを経て、
所定の容器に収容する。In using the tissue collecting needle of the present invention, first, the collecting needle is transported to the ovary via the vagina, and the tip of the hollow metal outer needle blade surface is punctured at the target site. Then
By changing the shape of the inner tube by changing the water content or temperature,
The tip of the inner tube is extended forward of the tip of the outer needle. Then, or at the same time, the washing water is sent from the gap between the outer needle and the inner needle via the liquid injection route. Aspirate the egg with the washing solution from the hollow part of the inner tube, and go through the tissue collection route,
Place in a designated container.
【００１４】以下、図面を引用して実施例により本発明
を詳細に説明する。図１は、本発明の組織採取針を利用
した洗浄吸引採卵装置の概念図を示し、図２は該組織採
取針の上面図を示し、図３は該組織採取針の断面図を示
し、図４は組織採取針を目的部位に穿刺した後の内管の
突出と洗浄液の流れを示す図である。図中、１は組織採
取針、２は中空金属外針、３は中空内針、４は分岐コネ
クター、５は洗浄液注入ライン（ルアコネクター）、６
は組織吸引ライン（ルアコネクター）、７は卵子採取試
験管、８は吸引器接続ラインを示す。また、９は外針と
内管との間の空隙を示す。空隙は金属外針基端部の分岐
コネクターにより中空金属外針および中空内管の軸方向
から側方に開放された液注入ルートおよび前記外針刃面
より内側に開口部を有し、かつ、外針針基の分岐コネク
ターの内部を通過する組織吸引ルートを形成する。Hereinafter, the present invention will be described in detail with reference to the drawings and embodiments. FIG. 1 shows a conceptual diagram of a washing and sucking egg collection apparatus using the tissue collecting needle of the present invention, FIG. 2 shows a top view of the tissue collecting needle, and FIG. 3 shows a cross-sectional view of the tissue collecting needle. FIG. 4 is a view showing the protrusion of the inner tube and the flow of the washing solution after the tissue sampling needle is punctured at the target site. In the figure, 1 is a tissue sampling needle, 2 is a hollow metal outer needle, 3 is a hollow inner needle, 4 is a branch connector, 5 is a washing liquid injection line (luer connector), 6
Indicates a tissue suction line (luer connector), 7 indicates an egg collection test tube, and 8 indicates an aspirator connection line. Further, 9 indicates a space between the outer needle and the inner tube. The void has a liquid injection route opened laterally from the axial direction of the hollow metal outer needle and the hollow inner tube by a branch connector of the metal outer needle base end and an opening portion inside the outer needle blade surface, and A tissue suction route is formed through the inside of the branch connector of the outer needle base.
【００１５】実施例１
図１〜４に示されるように、ステンレス（ＳＵＳ３０
４）である中空外針１（外径１．６ｍｍ、内径１．４ｍ
ｍ、長さ３５０ｍｍ）に、ポリウレタン製中空内管２
（外径１．１ｍｍ、内径０．８ｍｍ、長さ３７０ｍｍ
（吸水前））を内挿し、先端部外表面には研磨スリット
によるエコーガイドを設けた。外針基端部を分岐コネク
ター３内の洗浄液注入ライン５に接続させ、内管基端部
は分岐コネクター３内の組織吸引ライン６へ接続させ
た。使用したポリウレタン（サーメディックス社製、テ
コフレックス）は、約２０℃（室温）で湿度５０％の環
境から約３６℃（体温）で湿度１００％の環境変化にお
いて、含水率が約０．４％から１．５％へ変化し、さら
に、その長さが０．５％伸長する材料である。したがっ
て、吸水前に３７０ｍｍであった内管は、吸水後には３
７２ｍｍに伸長して、上記外針の先端から２ｍｍ突出す
る（図４参照）。上記組織採取針を膣から卵巣へ穿刺
し、上記エコーガイドへ体外から超音波を送信して、目
的部位に組織針が到達したことを確認してから、外針先
端の刃先を卵巣の卵胞へ穿刺し、次いで、シリンジから
洗浄液ラインを経由して洗浄水を送水すると同時に、伸
長した内管の突出部から洗浄液とともに卵子を吸引器接
続ラインにて吸引して、卵子を卵採取試験管内に収容す
る。 Example 1 As shown in FIGS. 1 to 4, stainless steel (SUS30
4) Hollow outer needle 1 (outer diameter 1.6 mm, inner diameter 1.4 m
m, length 350 mm), hollow inner tube 2 made of polyurethane
(Outer diameter 1.1 mm, inner diameter 0.8 mm, length 370 mm
(Before water absorption) was inserted, and an echo guide by a polishing slit was provided on the outer surface of the tip. The outer needle proximal end was connected to the washing liquid injection line 5 in the branch connector 3, and the inner tube proximal end was connected to the tissue suction line 6 in the branch connector 3. The used polyurethane (Thermex, Tecoflex) has a water content of about 0.4% when the environment changes from about 20 ° C (room temperature) and 50% humidity to about 36 ° C (body temperature) and 100% humidity. To 1.5%, and the length of the material is extended by 0.5%. Therefore, the inner pipe, which was 370 mm before absorbing water, becomes 3 mm after absorbing water.
It extends to 72 mm and projects 2 mm from the tip of the outer needle (see FIG. 4). Puncture the tissue collection needle from the vagina into the ovary, and transmit ultrasonic waves from outside the body to the echo guide to confirm that the tissue needle has reached the target site, then insert the tip of the outer needle into the follicle of the ovary. Puncture, then send the washing water from the syringe through the washing liquid line, and at the same time, suck the ovum together with the washing liquid through the aspirator connection line from the protruding part of the extended inner tube, and store the ovum in the egg collection test tube. To do.
【００１６】実施例２
実施例１と同様にして、ポリウレタン製組織採取針を製
造した。ただし、使用したポリウレタン（サーメディッ
クス社製、テコフィリック）は、約２０℃（室温）で湿
度５０％の環境から約３６℃（体温）で湿度１００％の
環境変化において、含水率が約０．４％から５．０％へ
変化し、さらに、その長さは１．０％伸長する材料であ
る。したがって、吸水前に３７０ｍｍであった内管は、
吸水後には３７４ｍｍに伸長して、上記外針の先端から
４ｍｍ突出する。 Example 2 In the same manner as in Example 1, a polyurethane tissue sampling needle was manufactured. However, the used polyurethane (Tecofic, manufactured by Thermedics Co., Ltd.) has a water content of about 0. 0 in an environment change of about 20 ° C (room temperature) and 50% humidity to about 36 ° C (body temperature) and 100% humidity. It is a material that changes from 4% to 5.0%, and further, extends its length by 1.0%. Therefore, the inner tube, which was 370 mm before absorbing water,
After absorbing water, it extends to 374 mm and projects 4 mm from the tip of the outer needle.
【００１７】実施例３
図１と同様なステンレス（ＳＵＳ３０４）である中空外
針１（外径１．６ｍｍ、内径１．４ｍｍ、長さ３５０ｍ
ｍ）に、形状記憶合金（日本精線製、Ni-Ti合金リメン
バロイ、ＡＦ点２５〜３７℃付近設定）から作製した(N
i-Ti)形状記録合金製中空内管２（外径１．１ｍｍ、内
径０．８ｍｍ、長さ３７２ｍｍ）を予め湾曲させ、３７
０ｍｍの全長になるよう変形させた上で内挿し、先端部
外表面にはサンドブラストによるエコーガイドを設け
た。外針基端部を分岐コネクター３内の洗浄液注入ライ
ン５に接続させ、内管基端部は分岐コネクター３内の組
織吸引ライン６へ接続させた。穿刺前の組織採取針の断
面を図５に示す。穿刺前の組織採取針の断面図を図５に
示す。従って、加温前（約２０℃）に３７０ｍｍであっ
た内管は、加温後（約３６℃）には３７２ｍｍに伸長し
て、上記外針の先端から２ｍｍ突出する。上記組織採取
針を膣から卵巣へ穿刺し、上記エコーガイドへ体外から
超音波を送信して、目的部位に組織針が到達したことを
確認してから、外針先端の刃先を卵巣の卵胞へ穿刺し、
次いで、シリンジから洗浄液ラインを経由して洗浄水を
送水すると同時に、伸長した内管の突出部から洗浄液と
ともに卵子を吸引器接続ラインにて吸引して、卵子を卵
採取試験管内に収容する。 Example 3 A hollow outer needle 1 made of stainless steel (SUS304) similar to that shown in FIG. 1 (outer diameter 1.6 mm, inner diameter 1.4 mm, length 350 m)
m), a shape memory alloy (Nihon Seisen Co., Ltd., Ni-Ti alloy Remember Roy, AF point set around 25-37 ° C) (N
i-Ti) Shape recording alloy hollow inner tube 2 (outer diameter 1.1 mm, inner diameter 0.8 mm, length 372 mm) was previously curved, and
It was deformed so as to have a total length of 0 mm and then inserted, and an echo guide by sandblasting was provided on the outer surface of the tip. The outer needle proximal end was connected to the washing liquid injection line 5 in the branch connector 3, and the inner tube proximal end was connected to the tissue suction line 6 in the branch connector 3. A cross section of the tissue sampling needle before puncture is shown in FIG. A cross-sectional view of the tissue sampling needle before puncturing is shown in FIG. Therefore, the inner tube which was 370 mm before heating (about 20 ° C.) extends to 372 mm after heating (about 36 ° C.) and projects 2 mm from the tip of the outer needle. Puncture the tissue collection needle from the vagina into the ovary, and transmit ultrasonic waves from outside the body to the echo guide to confirm that the tissue needle has reached the target site, then insert the tip of the outer needle into the follicle of the ovary. Puncture,
Next, the washing water is sent from the syringe through the washing liquid line, and at the same time, the egg is sucked together with the washing liquid from the extending portion of the inner tube through the aspirator connection line, and the egg is accommodated in the egg collection test tube.
【００１８】[0018]
【発明の効果】本発明では、金属外針と内管を二重構造
とし、内管を水分あるいは温度の変化により寸法変形す
る材料を採用することにより、卵巣へ組織採取針を穿刺
した後、洗浄液を該内管が水分を吸収して変形し、かつ
伸長して、穿刺した金属外針の刃面から突出した内管か
ら組織を吸引することにより、洗浄口と組織吸引口の位
置が離れて、洗浄液を直接に吸引することを防ぐことが
可能となる。INDUSTRIAL APPLICABILITY According to the present invention, the metal outer needle and the inner tube have a double structure, and the inner tube is made of a material that is dimensionally deformed by a change in water or temperature. The irrigation port is separated from the irrigation port by sucking the tissue from the inner tube protruding from the blade surface of the punctured metal outer needle by irrigating the irrigation solution to deform and expand the irrigation tube. Therefore, it is possible to prevent the cleaning liquid from being directly sucked.
【図１】本発明の組織採取針を利用した洗浄吸引採卵装
置の概念図である。FIG. 1 is a conceptual diagram of a washing suction egg collection device using a tissue collection needle of the present invention.
【図２】本発明の組織採取針の上面図である。FIG. 2 is a top view of the tissue sampling needle of the present invention.
【図３】本発明の組織採取針の断面図である。FIG. 3 is a cross-sectional view of the tissue sampling needle of the present invention.
【図４】穿刺後の内管の突出と洗浄液の流れを示す図で
ある。FIG. 4 is a view showing the protrusion of the inner tube and the flow of the cleaning solution after puncture.
【図５】内管が形状記憶合金である組織採取針の穿刺前
の断面図である。FIG. 5 is a cross-sectional view before puncturing a tissue sampling needle whose inner tube is a shape memory alloy.
Claims (5)
と、該外針に内挿された中空内管と、該外針および該内
管の基端部をそれぞれ固定する手段を備えた分岐コネク
ターとからなり、該内管が伸長することにより、内管先
端部が該外針刃面より前方に突出することを特徴とする
組織採取針。1. A hollow metal outer needle having a cutting edge at its tip, a hollow inner tube inserted in the outer needle, and means for fixing the outer needle and the proximal end portion of the inner tube, respectively. A tissue collecting needle comprising a branch connector, wherein the inner tube tip portion projects forward from the outer needle blade surface as the inner tube extends.
と、該外針に内装された中空内管と、該外針および該内
管の基端部をそれぞれ固定する手段を備えた分岐コネク
ターとからなり、前記中空金属外針と前記中空内管との
間に空隙が形成され、かつ、該空隙は金属外針基端部の
分岐コネクターにより中空金属外針および中空内管の軸
方向から側方に開放された液注入ルートおよび前記外針
刃面より内側に開口部を有し、かつ、外針針基の分岐コ
ネクターの内部を通過する組織吸引ルートを形成し、前
記内管が伸長することにより、内管先端部が該外針刃面
より前方に突出することを特徴とする組織採取針。2. A branch provided with a hollow metal outer needle having a tip provided with a cutting edge, a hollow inner tube provided inside the outer needle, and means for fixing the outer needle and the proximal end portion of the inner tube, respectively. And a hollow space formed between the hollow outer metal needle and the hollow inner pipe, and the space is formed by the branch connector at the proximal end of the metal outer needle and the hollow metal outer needle and the hollow inner pipe in the axial direction. Has a liquid injection route opened laterally from and an opening portion inside the outer needle blade surface, and forms a tissue suction route that passes through the inside of the branch connector of the outer needle needle base, and the inner tube A tissue sampling needle, wherein the tip of the inner tube projects forward from the blade surface of the outer needle by extending.
化により伸長する、請求項１または２記載の組織採取
針。3. The tissue collecting needle according to claim 1, wherein the hollow inner tube extends due to a change in water content or temperature.
化により変形する材料からなる、請求項１または２記載
の組織採取針。4. The tissue sampling needle according to claim 1, wherein the hollow inner tube is made of a material that deforms due to changes in moisture and temperature.
記憶合金である、請求項４記載の組織採取針。5. The tissue sampling needle according to claim 4, wherein the material is a water absorbent synthetic resin or a shape memory alloy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001331311A JP3829318B2 (en) | 2001-10-29 | 2001-10-29 | Tissue sampling needle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001331311A JP3829318B2 (en) | 2001-10-29 | 2001-10-29 | Tissue sampling needle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003126106A true JP2003126106A (en) | 2003-05-07 |
| JP3829318B2 JP3829318B2 (en) | 2006-10-04 |
Family
ID=19146913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001331311A Expired - Lifetime JP3829318B2 (en) | 2001-10-29 | 2001-10-29 | Tissue sampling needle |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3829318B2 (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008120824A1 (en) | 2007-03-30 | 2008-10-09 | Nipro Corporation | Metal needle usable in echo imaging |
| JP2009022193A (en) * | 2007-07-18 | 2009-02-05 | Fujitsu Ltd | Microinjection apparatus and method for injecting fluid |
| JP2010012247A (en) * | 2008-06-30 | 2010-01-21 | Imv Technologies | Instrument for intra-uterine transfer by natural vagino-uterine route |
| JP2010534332A (en) * | 2007-09-28 | 2010-11-04 | ヴィトロライフ スウェーデン アクチボラゲット | Sampling needle |
| WO2014115304A1 (en) | 2013-01-25 | 2014-07-31 | 株式会社北里メディカル | Needle for collecting living cell |
| JP2021526065A (en) * | 2018-05-29 | 2021-09-30 | グリーニング インベストメンツ プロプライアタリー リミティド | Needle for collecting human eggs |
| CN114711908A (en) * | 2022-03-11 | 2022-07-08 | 四川大学华西医院 | Puncture kit for uterine abdominal wall suspension operation |
-
2001
- 2001-10-29 JP JP2001331311A patent/JP3829318B2/en not_active Expired - Lifetime
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008120824A1 (en) | 2007-03-30 | 2008-10-09 | Nipro Corporation | Metal needle usable in echo imaging |
| US8287464B2 (en) | 2007-03-30 | 2012-10-16 | Nipro Corporation | Metal needle usable in echo imaging |
| JP2009022193A (en) * | 2007-07-18 | 2009-02-05 | Fujitsu Ltd | Microinjection apparatus and method for injecting fluid |
| JP2010534332A (en) * | 2007-09-28 | 2010-11-04 | ヴィトロライフ スウェーデン アクチボラゲット | Sampling needle |
| US9907571B2 (en) | 2007-09-28 | 2018-03-06 | Vitrolife Sweden Ab | Sampling needle |
| EP2114270B2 (en) † | 2007-09-28 | 2019-06-19 | Vitrolife Sweden AB | Sampling needle |
| US10765454B2 (en) | 2007-09-28 | 2020-09-08 | Vitrolife Sweden Ab | Sampling needle |
| JP2010012247A (en) * | 2008-06-30 | 2010-01-21 | Imv Technologies | Instrument for intra-uterine transfer by natural vagino-uterine route |
| WO2014115304A1 (en) | 2013-01-25 | 2014-07-31 | 株式会社北里メディカル | Needle for collecting living cell |
| US10194940B2 (en) | 2013-01-25 | 2019-02-05 | Kitazato Corporation | Living cell collection needle |
| JP2021526065A (en) * | 2018-05-29 | 2021-09-30 | グリーニング インベストメンツ プロプライアタリー リミティド | Needle for collecting human eggs |
| CN114711908A (en) * | 2022-03-11 | 2022-07-08 | 四川大学华西医院 | Puncture kit for uterine abdominal wall suspension operation |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3829318B2 (en) | 2006-10-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106604687B (en) | To contain the sheath component and multiholed catheter of the endoscopic surgical operations of the different field of suction, flushing and material removal | |
| US20190054271A1 (en) | Flushable catheter device | |
| JP2003126106A (en) | Tissue collection needle | |
| JP6050837B2 (en) | Biological cell collection needle | |
| CN208287287U (en) | A kind of bladder blood block cleaning device | |
| CN205307581U (en) | Two sets of drainage flushing pipes | |
| CN101984923B (en) | Puncture needle special for aseptic ovum retrieval and aseptic ovum retrieval needle device thereof | |
| CN201046152Y (en) | Device for picking oosphere | |
| JP4123506B2 (en) | Tissue suction collection device | |
| CN101692982A (en) | Novel asepsis single cavity ovum-picking needle device | |
| CN203196121U (en) | Aspirator for endoscope surgery | |
| CN2215283Y (en) | Changeable trocar for puncture of pleura and peritoneum | |
| CN209848048U (en) | Debridement suction irrigator | |
| JP2001190560A (en) | Ovum collection needle and washing and absorbing ovum collection device using the same | |
| CN217138120U (en) | Puncture needle for cytology examination | |
| CN201595916U (en) | Disposable dual-cavity egg taking needle | |
| CN218075146U (en) | Suction surgical scissors | |
| CN211094304U (en) | Flush tube assembly and probe assembly | |
| RU51339U1 (en) | DEVICE FOR LIQUID FEEDING FROM CLOSED CAVITAS | |
| CN200948172Y (en) | Multifunctional one-off operation towel | |
| JPS5964066A (en) | Medical discharge pipe | |
| CN110025368B (en) | Ovarian injection device and device for diagnosing, preventing or treating ovarian diseases | |
| CN220558340U (en) | Intestinal tract flushing suction device | |
| CN219661702U (en) | Double needle type wound probe | |
| CN201683990U (en) | Novel sterile single-lumen ovum aspiration needle device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20051226 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060224 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20060619 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20060702 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 3829318 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090721 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120721 Year of fee payment: 6 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120721 Year of fee payment: 6 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150721 Year of fee payment: 9 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |