JP2003111821A - Method of preparing medicine and device for preparing liquid medicine - Google Patents

Abstract

PROBLEM TO BE SOLVED: To quickly and accurately prepare an appropriate amount of medicine. SOLUTION: A liquid medicine preparation device 1 using liquid metering and discharging mechanisms comprises a host computer 3 which imparts information about an individual's past history, genetic information, present condition of disease, and medicines to an inference system to execute an inference system for obtaining a prescription control signal for making up the most appropriate medicine for curing the individual's current condition of disease; a storage part 5 provided with a plurality of medicine storage tanks 51a, 51b, 51c, and so forth for storing liquid medicines; a plurality of liquid metering and discharging mechanisms 7, 7 and so forth which are allowed to individually communicate with the plurality of medicine storage tanks 51a, 51b, 51c and so forth of the storage part 5; and a control part 9 capable of controlling the drive of the individual liquid metering and discharging mechanisms 7, 7 and so forth in response to the prescription control signal coming from the host computer 3.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a drug preparation method and a device therefor, and more particularly to a drug preparation method and a liquid preparation method capable of preparing an optimum liquid drug for curing it based on individual medical history, genetic information, current medical condition and the like. Liquid drug compounding device.

[0002]

2. Description of the Related Art Generally, in a medical institution, a doctor diagnoses a medical condition of an individual, a doctor prescribes an optimal drug for the medical condition, and a pharmacist prepares the drug at a pharmacy according to the prescription. In order to automate this dispensing operation, various medicine packaging machines are provided. This packaging machine is one in which a drug is automatically packaged when a pharmacist inputs necessary items in accordance with a doctor's prescription.

On the other hand, medical institutions often have a computer for medical accounting, and in this case, the same items as those input to the packaging machine are input to the computer for medical accounting. A dispensing control method has been proposed in which the waste of making such double input is eliminated and the data handled by the host computer installed in the medical institution is used to allow the dispensing data to be dispensed by the dispensing machine. Kaihei 7-24035). According to this dispensing control method, there is an advantage that the labor of double input can be saved, an input operation error can be eliminated, and erroneous medication can be eliminated.

[0004]

However, according to the above-mentioned conventional preparation control method, a drug such as a tablet or a powder can be prepared, but a liquid drug cannot be prepared.

On the other hand, as genetic analysis progresses, it becomes necessary to find a drug suitable for each individual. in this case,
Drugs will be roughly compounded by pharmaceutical companies, and more personalized drugs will be compounded by local medical institutions. In other words, the basic drug (medicine solution) is manufactured by a pharmaceutical company, and in a local medical institution, a plurality of basic drug solutions are combined in consideration of the medical condition, and the mixing ratio is changed individually. .

For example, in the case of a cold, the drugs A, B, C and D are prepared in a ratio of 1: 1: 1: 1 for some people and different ratios for others. It will be compounded.
In this case, if a person intervenes in the formulation, an incorrect drug type or an incorrect drug amount may occur. Even an excellent doctor cannot easily formulate an optimal drug for treatment of a disease in consideration of the patient's past medical history, genetic information, current medical condition, and the like.

The present invention has been made in view of the above-mentioned circumstances, and an object of the present invention is to enable rapid and accurate preparation of an appropriate amount of a drug. Another object of the present invention is to make it possible to easily obtain a medicine having a different compounding ratio for each individual. And, the present invention enables liquid medications to be dispensed quickly and accurately.

[0008]

[Means for Solving the Problems] In order to achieve the above-mentioned object, a method for preparing a drug according to the present invention comprises:
Based on genetic information, personal information such as current medical condition, and a plurality of pre-given drugs, a pre-specified inference algorithm is used to obtain optimal drug formulation information for curing the current medical condition of the individual. Then, after that, the plurality of medicines are prepared based on the medicine preparation information.

According to the drug preparation method of the present invention, it is possible to quickly and accurately prepare an appropriate amount of a liquid drug. In addition, the optimum medicine suitable for each individual can be easily prepared. The drug may be liquid, powder, granular, or the like. In this case, the liquid constant-volume discharge device is an inkjet head. Since the ink jet is used, it is possible to supply an accurate drug amount and to prepare an accurate formulation.

The liquid drug preparation device according to the present invention provides the inference system with the past medical history, genetic information, and current medical condition of an individual, and prepares the optimal drug for curing the current medical condition of the individual. A host computer that executes an inference system that obtains a plurality of liquid medicines, a storage unit that includes a plurality of drug storage tanks that store each of a plurality of liquid medicines, and a plurality of liquid quantitative discharges that communicate with each of the drug storage tanks of the storage unit. And a control unit that receives the dispensing control signal from the host computer and can individually drive and control each of the liquid fixed amount ejection units.

According to the liquid drug preparation device of the present invention,
It is possible to provide a device capable of accurately and properly preparing a permanent drug, and easily prepare an optimal liquid drug for an individual.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION Preferred embodiments of a drug preparation method and a liquid drug preparation device according to the present invention will be described with reference to the accompanying drawings. FIG. 1 is a configuration diagram showing a liquid drug preparation device that realizes the drug preparation method according to the present invention. In FIG. 1, a liquid medicine preparation device 1 according to the present invention is installed in a medical institution, and a host computer 3 that outputs a preparation control signal relating to an optimum medicine for an individual, and a plurality of liquid medicines can be stored and individually provided. A storage unit 5, a plurality of liquid fixed amount discharge mechanisms (liquid fixed amount discharge units) 7, which discharge each drug from the storage unit 5 by a drive control signal, and a dispensing control signal from the host computer 3 are received. , And a control unit 9 for individually driving and controlling the predetermined liquid quantitative discharge mechanisms 7, 7, ... In response to the dispensing control signal.

To explain further, the host computer 3
Is a computer main body, a keyboard,
Mouse, CD-ROM, CD-R, CD-RW, DV
D or an input device such as an IC card reader,
At least an output device such as a display and a printer and a communication device for communicating with an external device are provided.

Further, the computer main body 30 of the host computer 3 includes an arithmetic processing unit (not shown) for executing various arithmetic processes, and a main memory for expanding and storing an operating system, an application program, an inference system program and various data ( (Not shown), an input / output interface (not shown) with an input device, an output device, and a communication device, and a hard disk drive device 31.

The hard disk drive device 31 has an operating system (not shown) created in a predetermined language, an application program (not shown) running on the operating system, and an operating system running on the operating system. A medical inference system program 33 that executes a given inference algorithm and a database 34 that stores various data are stored. The database 34 stores individual past medical history information 35, individual genetic information 36, and the like.

Further, the host computer 3 is provided with an input unit 37 for inputting the current medical condition of an individual. In addition, the host computer 3 is provided with a correction device 38 which allows the doctor to optimize the inference system. The reasoning system is
It is created in advance based on various treatment results announced or published by medical associations and various treatment institutions. The computer main body 30 of the host computer 3 is electrically connected to the communication device of the control unit 9 via a communication device,
A dispensing control signal can be given to the control unit 9.

The above-mentioned storage section 5 is composed of a plurality of drug storage tanks 51a, 5a respectively storing a plurality of types of liquid drugs.
1b, 51c, ... Are mounting parts 52a, 52b, 52c ,.
Each is detachably attached to. The drug storage tanks 51a, 51b, 51c, ...
It is designed to be mounted only on a, 52b, 52c, ..., and cannot be mounted on other mounting parts. Drug storage tanks 51a, 51b, 51c,
The chemicals of ... Are supplied to the liquid fixed amount ejection mechanisms 7, 7, ... Via the mounting portions 52a, 52b, 52c, ... And the chemical supply lines 53a, 53b, 53c ,.

A drug collecting container 11 is arranged at each of the discharge parts of the liquid fixed amount discharge mechanisms 7, 7, ..., And the liquid medicine discharged from each liquid fixed amount discharge mechanism 7, 7 ,. It is like this. The liquid quantitative discharge mechanism 7 is configured similarly to an inkjet head of a so-called inkjet printer. It is preferable to use a so-called laminated PZT system in which plate-shaped zircon / lead titanate-based ceramics are laminated as the liquid quantitative discharge mechanism 7. The laminated PZT method has a feature that a large displacement amount can be obtained and the frequency response is high.
This is because it is suitable for discharging an accurate amount of medicine.

The liquid quantitative discharge mechanism 7 of the laminated PZT system applies a predetermined drive signal pattern (a temporal potential change pattern of “neutral potential” → “plus potential” → “minus potential” → “neutral potential”). As a result, droplets can be formed. Further, the liquid quantitative discharge mechanism 7 of the laminated PZT system is capable of adjusting the amount of droplets by changing the pattern. Therefore, the drive signal of the liquid quantitative ejection mechanism 7 is given from the control unit 9 with the drive signal pattern. Here, the drug storage tanks 51a, 51b, 51c,
... and the liquid fixed amount ejection mechanisms 7, 7, ... Have a scale capable of handling several kinds to several hundred kinds of medicines.

The control section 9 described above is electrically connected to the liquid quantitative discharge mechanisms 7, 7, ..., And is capable of giving a drive signal to the liquid quantitative discharge mechanisms 7, 7 ,. And a communication device for connecting the control unit body to the host computer 3. Further, the control unit main body stores and stores a central processing unit that creates a drive command for driving the liquid quantitative dispensing mechanisms 7, 7, ... In response to a dispensing control signal, and a program that operates the central processing unit. The main memory and the drive command,
At least an input / output interface for converting into a drive signal given to 7, ...

The operation of the liquid medicine blending apparatus 1 using the liquid quantitative dispensing mechanism constructed as described above will be described with reference to FIG. FIG. 2 is a flow chart for explaining the operation (medicine mixing method) of the liquid medicine mixing apparatus 1 according to the present invention.

The database 34 of the hard disk drive device 31 stores in advance information 35 on the past medical history of each individual.
It is assumed that the gene information 36 of each individual, the information (not shown) of a plurality of liquid medicines stored in the storage unit 5, and the like are stored. It is assumed that the database 34 stores information about past medical history 35 of each individual and genetic information 36 of each individual.
When is not stored, IC issued by medical institution
The information on the past medical history of the individual and the genetic information of the individual are read from the card through the IC card reading device and stored in the database 34 in advance. Further, it is assumed that the computer main body 30 of the host computer 3 reads the medical inference system program 33 from the hard disk drive device 31, expands and stores it in the main memory, and executes it to construct an inference system.

First, when the personal information of a certain individual or the current medical condition of the individual is input through the input unit 37, the computer main body 30 of the host computer 3 stores the past information of the individual in the database 34 of the hard disk drive device 31. The medical history information 35 and the genetic information 36 of the individual are read out, and the current medical condition, the past medical history information 35 of the individual and the genetic information 36 of the individual are given to the inference system (step 101).

The inference system executed in the computer main body 30 of the host computer 3 includes information on the current medical condition of the individual, information 35 on the past medical history of the individual, genetic information 36 on the individual, Based on the information on the liquid drug stored in the storage unit 5, a dispensing control signal for preparing a drug most suitable to cure the current medical condition of the individual is created (step 102). Host computer 3
The computer main body 30 provides the dispensing control signal to the control unit 9 via the communication device (step 103), and ends the process.

After that, the control section main body of the control section 9 determines the liquid quantitative discharge mechanisms 7, 7, ... Which should be driven in accordance with the received dispensing control signal, and at the same time outputs the driving signal necessary for dispensing. Then, the drive signal is formed and output to the determined liquid fixed amount ejection mechanisms 7, 7, .... As a result, the liquid fixed amount ejection mechanisms 7, 7, ... To which the drive signal is applied ejects the liquid medicine in an amount corresponding to the drive signal to the medicine collecting container 11. As a result, it is possible to automatically prepare the optimal drug preparation for the individual without human intervention.

According to the above-described embodiment, the past medical history, genetic information, and current medical condition of an individual are given to the host computer, and the reasoning system by the host computer is most suitable to cure the current medical condition of the individual. It is a method of preparing various medicines, and by operating a predetermined liquid fixed-quantity discharge device in response to a preparation control signal from the host computer, a medicine adapted to cure the medical condition of the individual can be quickly and accurately prepared. Can be (no doubt) mixed in. The liquid medicine described above may be a drunk medicine, a drip infusion, an injection solution, or the like.

In the above-described embodiment, the medical institution is divided into a medical office and a pharmacy, so the host computer 3 and the control unit 9 are separately configured. However, the present invention is not limited to this. 3 and the control unit 9 may be integrated. Further, in the above embodiment,
Although the case where the drug is a liquid has been described, the drug may be in the form of powder or granules.

[0028]

As described above, in the pharmaceutical preparation method according to the present invention, the past medical history, genetic information, current medical condition, etc. of an individual are given to the host computer, and the inference system by the host computer presents the current state of the individual. Since the optimal drug for curing the medical condition is prepared, it is possible to rapidly and accurately prepare the optimal drug for curing the medical condition of the individual.

[Brief description of drawings]

FIG. 1 is a configuration diagram showing a liquid medicine preparation device for realizing a medicine preparation method according to an embodiment of the present invention.

FIG. 2 is a flowchart for explaining the operation of the liquid drug preparation device according to the embodiment of the present invention.

[Explanation of symbols]

1 ...... Medicine blending device, 3 ......... host computer,
5: storage section, 7: liquid constant quantity discharge section (liquid constant quantity discharge mechanism), 9: control section, 11: medicine collection container,
51a, 51b, 51c ......... Medication storage tank, 52
a, 52b, 52c ... Mounting portion, 53a, 53b,
53c ......... Pharmaceutical supply line.

Claims (2)

[Claims] 1. A current medical condition of an individual based on personal information such as an individual's past medical history, genetic information, current medical condition, and a plurality of drugs given in advance, using an inference algorithm given in advance. A method for preparing a medicine, characterized by obtaining optimum medicine preparation information for curing the above, and then preparing the plurality of medicines based on the medicine preparation information. 2. A host for executing an inference system, which provides an inference system with an individual's past medical history, genetic information, current medical condition, etc., and obtains a dispensation control signal for preparing an optimal drug for curing the individual's current medical condition. A computer, a storage unit provided with a plurality of drug storage tanks for storing each of a plurality of liquid drugs, a plurality of liquid quantitative discharge units in communication with each of the drug storage tanks of the storage unit, and a host computer A liquid medicine preparation device, comprising: a control unit which receives a dispensing control signal and can drive and control each of the liquid fixed amount ejection units individually.