JP2003107195A - Managing method and managing system for biochemical analysis unit - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a managing system for biochemical analysis unit capable of positively managing a biochemical analysis unit hybridizing a substance derived from an organism and labeled with a radioactive labeling substance with a specific bonding substance and using it in biochemical analysis until a level of activity is decayed to a predetermined level or less. SOLUTION: The managing system for biochemical analysis unit 1 with a plurality of mutually separated absorptive areas 4 involving the specific bonding substance with a known structure or characteristic, is characterized by providing with a management data recorder 10 recording management data including data for a time to be used as a basis for calculating a decay time of radiation involved in the radioactive labeling substance in the unit for biochemical analysis.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a biochemical analysis unit management method and management system, and more specifically, to a biologically-derived substance labeled with a radiolabeled substance as a specific binding substance. The unit for biochemical analysis, which was hybridized and used for biochemical analysis,
The present invention relates to a management method and a management system for a biochemical analysis unit, which can reliably manage the level of radioactivity until it falls below a predetermined level.

[0002]

2. Description of the Related Art When a radiation is irradiated, the energy of the radiation is absorbed, stored and recorded, and then excited by using an electromagnetic wave of a specific wavelength range. A photostimulable phosphor having the property of emitting a stimulating amount of light is used as a radiation detection material, and a substance having a radioactive label is administered to an organism, and then the organism or tissue of the organism is treated. A portion of the sample is used as a sample, and this sample is overlapped with a stimulable phosphor sheet provided with a stimulable phosphor layer for a certain period of time to store and record radiation energy in the stimulable phosphor. , Scanning the stimulable phosphor layer with electromagnetic waves to excite the stimulable phosphor and photoelectrically detecting the stimulable light emitted from the stimulable phosphor to generate a digital image signal. Image processing, CRT On a recording material such as a display unit or on the photographic film, the autoradiographic analyzing system is configured to reproduce an image has been known (for example, Kokoku 1-70884 and JP Kokoku 1-70
882, Japanese Patent Publication No. 4-3962, etc.).

An autoradiography analysis system using a stimulable phosphor sheet as a radiation detecting material not only requires a chemical treatment called a developing treatment, unlike the case where a photographic film is used, but also was obtained. By subjecting the digital data to data processing, there is an advantage that the analysis data can be reproduced or a quantitative analysis by a computer can be performed as desired.

On the other hand, there is known a fluorescence analysis system using a fluorescent substance such as a fluorescent dye as a labeling substance instead of the radioactive labeling substance in the autoradiography analysis system. According to this fluorescence analysis system, by detecting the fluorescence emitted from the fluorescent substance, the gene sequence, the expression level of the gene, the metabolism, absorption, and excretion routes of the administered substance in the experimental mouse, the state, the separation of the protein, Identification or evaluation of molecular weight and characteristics can be performed. For example, a solution containing plural kinds of protein molecules to be electrophoresed is electrophoresed on the gel support, and then the gel support is subjected to fluorescence. An image is generated by staining the electrophoresed protein by immersing it in a solution containing a dye, exciting the fluorescent dye with excitation light, and detecting the resulting fluorescence, and then producing an image on the gel support. The position and quantitative distribution of protein molecules can be detected. Alternatively, by Western blotting,
A probe and a protein molecule prepared by transferring at least a part of the electrophoresed protein molecule onto a transfer support such as nitrocellulose and labeling an antibody that specifically reacts with the target protein with a fluorescent dye are prepared. By selectively associating and selectively labeling a protein molecule that binds only to an antibody that specifically reacts,
By exciting the fluorescent dye with the excitation light and detecting the generated fluorescence, an image can be generated and the position and quantitative distribution of the protein molecule on the transfer support can be detected. In addition, after adding a fluorescent dye to a solution containing a plurality of DNA fragments to be electrophoresed, the plurality of DNA fragments are electrophoresed on a gel support, or on a gel support containing a fluorescent dye. , A plurality of DNA fragments are electrophoresed, or a plurality of DNA fragments are electrophoresed on a gel support, and then the gel support is immersed in a solution containing a fluorescent dye. DNA fragments are labeled, a fluorescent dye is excited by excitation light, and the resulting fluorescence is detected to generate an image, and the distribution of DNA on the gel support is detected, or a plurality of DNAs are detected.
The fragments are electrophoresed on a gel support, followed by DNA
Denaturation, and then by Southern blotting, at least a part of the denatured DNA fragment is transferred onto a transfer support such as nitrocellulose, and DNA or RNA complementary to the target DNA is fluorescent dye. A probe DNA or probe RN prepared by hybridizing a probe prepared by labeling with
Only the DNA fragment complementary to A is selectively labeled, the fluorescent dye is excited by the excitation light, and the resulting fluorescence is detected to generate an image, so that the DNA of interest on the transfer support is detected. The distribution can be detected. further,
DN containing a target gene labeled with a labeling substance
A DNA probe complementary to A is prepared, hybridized with the DNA on the transcription support, and the enzyme is allowed to bind to the complementary DNA labeled with a labeling substance, and then contacted with a fluorescent substrate for fluorescence. An image is generated by changing the substrate to a fluorescent substance that emits fluorescence, exciting the generated fluorescent substance with excitation light, and detecting the generated fluorescence,
It is also possible to detect the distribution of the target DNA on the transcription support. This fluorescence analysis system has an advantage that gene sequences and the like can be easily detected without using radioactive substances.

Similarly, a substance derived from a living body such as a protein or a nucleic acid is immobilized on a support and is selectively labeled with a labeling substance which causes chemiluminescence by contacting with a chemiluminescent substrate. A selectively labeled biological substance is brought into contact with a chemiluminescent substrate, and chemiluminescence in the visible light wavelength region generated by the contact between the chemiluminescent substrate and the labeled substance is photoelectrically detected to obtain a digital image signal. Chemiluminescence for generating information, reproducing the chemiluminescence image on a display material such as a CRT or a recording material such as a photographic film by performing image processing, and obtaining information on a substance of biological origin such as gene information. Analysis systems are also known.

Furthermore, in recent years, cells at different positions on the surface of a carrier such as a slide glass plate or a membrane filter,
Viruses, hormones, tumor markers, enzymes, antibodies, antigens, abzymes, other proteins, nucleic acids, cDNA
A specific binding substance, such as A, DNA, or RNA, which can be specifically bound to a substance of biological origin and whose base sequence, base length, composition, etc. is known, is dropped using a spotter device. , Forming a large number of independent spots, then cells, viruses, hormones, tumor markers, enzymes, antibodies, antigens, abzymes, other proteins, nucleic acids, c
A substance derived from a living body, such as DNA, DNA, or mRNA, which is collected from the living body by extraction or isolation, or which is further subjected to a chemical treatment, a chemical modification, or the like, such as a fluorescent substance or a dye. A substance labeled with a labeling substance is bound to a specific binding substance by hybridization or the like, to a microarray that is specifically bound,
A microarray analysis system has been developed which irradiates excitation light and photoelectrically detects light such as fluorescence emitted from a labeling substance such as a fluorescent substance or a dye to analyze a substance derived from a living body. According to this microarray analysis system,
A large number of spots of specific binding substances are formed at high density at different positions on the surface of a carrier such as a slide glass plate or a membrane filter, and the substance of biological origin labeled with the labeling substance is hybridized, thus In time, there is an advantage that it is possible to analyze a substance of biological origin.

In addition, cells, viruses, hormones, tumor markers, enzymes, antibodies, antigens, abzymes, other proteins, nucleic acids, cDNAs, DNAs, RNAs, etc. derived from living organisms are located at different positions on the surface of a carrier such as a membrane filter. The specific binding substance that can specifically bind to the substance of which the base sequence, base length, composition, etc. are known is dropped using a spotter device to form a large number of independent spots. , Then, cells, viruses, hormones, tumor markers, enzymes, antibodies, antigens, abzymes, other proteins, nucleic acids, cDNAs, DNAs, mRNAs, etc., collected from the living body by extraction or isolation, or
Furthermore, a substance derived from a living body, which has been subjected to a chemical treatment, a chemical modification, or the like, and which is labeled with a radioactive labeling substance, is specifically bound to a specific binding substance by hybridization or the like. Macro array,
The stimulable phosphor layer containing the stimulable phosphor is brought into close contact with the stimulable phosphor sheet, and the stimulable phosphor layer is exposed.
After that, the photostimulable phosphor layer is irradiated with excitation light, the photostimulable light emitted from the photostimulable phosphor layer is photoelectrically detected, and biochemical analysis data is generated. A macroarray analysis system using a radiolabeled substance for analyzing is also developed.

[0008]

In a macroarray analysis system using a radioactive labeling substance as a labeling substance, a biochemical analysis unit such as a membrane filter used for biochemical analysis is used to control the radioactive substance. Is required to be controlled over a period of time until the level of
Conventionally, a user writes the date and time when hybridization was performed on a biochemical analysis unit such as a membrane filter, and the radioactivity was determined according to the date and time when hybridization was performed and the nuclide of the radiolabeled substance used. It was common practice to manage the biochemical analysis unit until the level of ## EQU1 ## decays below a predetermined level, and then discard the biochemical analysis unit.

However, in the case of managing the biochemical analysis unit such as the membrane filter in this way, the user may mistakenly write the date and time or the date when the hybridization was performed into the biochemical analysis unit. , If you forget to write the date and time of the hybridization in the biochemical analysis unit, according to the nuclide of the radiolabeled substance, make sure that the level of radioactivity decays below a predetermined level, There was a problem that the unit for biochemical analysis could not be managed.

Therefore, according to the present invention, a substance derived from a living body labeled with a radiolabeled substance is hybridized with a specific binding substance, and the biochemical analysis unit used for biochemical analysis has a radioactivity level of It is an object of the present invention to provide a management method and a management system for a biochemical analysis unit, which can be managed reliably until it is attenuated below a predetermined level.

[0011]

The object of the present invention is to:
A method for managing a biochemical analysis unit in which a plurality of absorptive regions containing specific binding substances having known structures or characteristics are separated from each other. For biochemical analysis, which is characterized in that management data including data relating to time serving as a reference for calculating the decay time of radiation contained in the radiolabeled substance is recorded in the biochemical analysis unit when performing the analysis. Achieved by the unit management method.

According to the present invention, when the biochemical analysis is performed using the biochemical analysis unit, the management data including the data about the time serving as the reference for calculating the decay time of the radiation contained in the radiolabeled substance. Is recorded in the biochemical analysis unit, it is used based on the time data that is the standard for calculating the decay time of the radiation contained in the radiolabeled substance recorded in the biochemical analysis unit. According to the nuclide of the radiolabeled substance, the biochemical analysis unit used for biochemical analysis,
It is ensured that the level of radioactivity of the radiolabeled substance is controlled until it decays below a predetermined level, and it can be discarded after the level of radioactivity of the radiolabeled substance decays below a predetermined level.

In a preferred embodiment of the present invention, a specific binding substance contained in the plurality of absorptive regions of the biochemical analysis unit is derived from a living body labeled with a radiolabeling substance by a hybridization device. When selectively hybridizing a substance, management data including data relating to a time serving as a reference for calculating a decay time of radiation contained in the radiolabeled substance by the hybridization device is used for the biochemical analysis. The unit is configured to record.

According to a preferred embodiment of the present invention, the specific binding substance contained in the plurality of adsorptive regions of the biochemical analysis unit is labeled with a radiolabeling substance by a hybridization device, and the substance is of biological origin. When selective hybridization is performed, the hybridization device records management data including data on time used as a reference for calculating the decay time of the radiation contained in the radiolabeled substance in the biochemical analysis unit. Therefore, based on the data on the time that is the reference for calculating the decay time of the radiation contained in the radiolabeled substance recorded in the biochemical analysis unit, according to the nuclide of the radiolabeled substance used, Make sure that the unit for biochemical analysis used for biochemical analysis is Until the bell has decayed below a predetermined level, managing, after the level of radioactivity of the radioactive labeling substance has decayed below a predetermined level, it is possible to discard.

[0015] In a further preferred aspect of the present invention, the data on the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes data on the date and time at which the hybridization is carried out.

[0016] According to a further preferred embodiment of the present invention, the biochemical analysis is performed according to the radionuclide nuclide used, based on the date and time of the hybridization recorded in the biochemical analysis unit. The used biochemical analysis unit was managed until the level of radioactivity of the radiolabeled substance decreased to a predetermined level or lower, and the radioactivity level of the radiolabeled substance decreased to a predetermined level or lower. It can later be discarded.

In another preferred embodiment of the present invention, the data on the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes the data on the day on which the hybridization is carried out.

According to another preferred embodiment of the invention,
Based on the data recorded on the biochemical analysis unit regarding the date when the hybridization is performed, ensure that the biochemical analysis unit used for biochemical analysis is radioactive according to the radionuclide nuclide used. It is possible to manage until the radioactivity level of the labeling substance decays below a predetermined level, and to discard it after the radioactivity level of the radiolabeling substance decays below a predetermined level.

In a preferred embodiment of the present invention, a specific binding substance contained in the plurality of absorptive regions of the biochemical analysis unit is derived from a living body labeled with a radioactive labeling substance by a hybridization device. After selectively hybridizing the substance, the biochemical analysis unit is provided with a support by an exposure device, and a stimulable phosphor layer containing a stimulable phosphor is formed on the support. The stimulable phosphor sheet, and when exposed by the radioactive labeling substance selectively contained in the plurality of absorptive regions of the biochemical analysis unit, the exposure device causes the radioactive labeling substance to be exposed. Is configured to record management data including data relating to a time serving as a reference for calculating a radiation decay time included in the biochemical analysis unit. That.

According to a preferred embodiment of the present invention, the specific binding substance contained in the plurality of absorptive regions of the biochemical analysis unit is labeled with a radioactive labeling substance by a hybridization device, and the substance is of biological origin. Selectively, after hybridizing, by an exposure device,
The biochemical analysis unit is provided with a support, and the support is superposed on a stimulable phosphor sheet having a stimulable phosphor layer containing a stimulable phosphor, and the biochemical analysis unit is stacked to form a plurality of biochemical analysis units. Radioactive substance selectively contained in the absorptive region of, when exposed, by the exposure device, management data including data about the time to be the reference to calculate the decay time of the radiation contained in the radiolabeled substance, Since it is configured to record in the biochemical analysis unit, it was used based on the time-related data recorded in the biochemical analysis unit, which is the reference for calculating the decay time of the radiation contained in the radiolabeled substance. Depending on the nuclide of the radiolabeled substance, ensure that the biochemical analysis unit used for biochemical analysis attenuates the radioactivity level of the radiolabeled substance to below the prescribed level. Up, manage, after the level of radioactivity of the radioactive labeling substance has decayed below a predetermined level, it is possible to discard.

[0021] In a further preferred aspect of the present invention, the data regarding the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes data regarding the date and time when the exposure operation is performed.

According to a further preferred embodiment of the present invention, the biochemical analysis is carried out according to the nuclide of the radiolabeled substance used, based on the data on the date and time when the exposure operation is performed, which is recorded in the biochemical analysis unit. The used biochemical analysis unit was managed until the level of radioactivity of the radiolabeled substance decreased to a predetermined level or lower, and the radioactivity level of the radiolabeled substance decreased to a predetermined level or lower. It can later be discarded.

In another preferred embodiment of the present invention, the data on the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes the data on the day on which the exposure operation is performed.

According to another preferred embodiment of the invention,
Make sure that the biochemical analysis unit used for the biochemical analysis is made radioactive according to the nuclide of the radiolabeled substance used, based on the data recorded on the biochemical analysis unit regarding the date on which the exposure operation is performed. It is possible to manage until the radioactivity level of the labeling substance decays below a predetermined level, and to discard it after the radioactivity level of the radiolabeling substance decays below a predetermined level.

[0025] In a preferred aspect of the present invention, the data on the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes data on the date and time when the radiolabeled substance was produced.

According to a preferred embodiment of the present invention, since the data on the date and time when the radiolabeled substance is produced is recorded in the biochemical analysis unit, the date and time when the radiolabeled substance recorded in the biochemical analysis unit is produced. According to the radionuclide nuclide used, the unit for biochemical analysis used for biochemical analysis can be managed more reliably until the radioactivity level of the radiolabeled substance decays below a prescribed level. However, after the radioactivity level of the radio-labeled substance is attenuated below a predetermined level, it becomes possible to dispose of it.

[0027] In another preferred embodiment of the present invention, the data on the time serving as a reference for calculating the decay time of the radiation contained in the radio-labeled substance includes data on the date on which the radio-labeled substance is produced.

According to another preferred embodiment of the invention,
Since the data regarding the date and time when the radiolabeled substance was generated is recorded in the biochemical analysis unit, the data regarding the date when the radiolabeled substance was recorded recorded in the biochemical analysis unit was used according to the nuclide of the radiolabeled substance used. Biochemical analysis unit used for biochemical analysis,
More surely, it is possible to manage until the radioactivity level of the radiolabeled substance falls below a predetermined level, and to discard it after the radioactivity level of the radiolabeled substance decays below a predetermined level. .

[0029] In a preferred aspect of the present invention, the biochemical analysis unit includes a substrate having a plurality of holes separated from each other, and the plurality of absorptive regions are formed on the substrate. The plurality of pores are filled with an adsorptive material, the adsorptive material filled in the plurality of pores is formed by containing the specific binding substance, and is formed on the substrate of the biochemical analysis unit. , Is configured to record the management data.

According to a preferred embodiment of the present invention, the biochemical analysis unit comprises a substrate in which a plurality of holes are formed separately from each other, and a plurality of absorptive regions are formed in a plurality of substrates. Since the holes are filled with the adsorptive material and the adsorptive material filled in the plurality of holes is made to contain the specific binding substance, the intervals between the adjacent adsorptive regions can be set as desired. Therefore, the specific binding substance contained in the adsorptive region of the biochemical analysis unit is selectively changed from the biologically-derived substance labeled with the radiolabeled substance by the hybridization device, After hybridizing, the stimulable phosphor layer formed on the stimulable phosphor sheet is exposed to a radioactive labeling substance contained in the absorptive region of the biochemical analysis unit to illuminate the stimulable phosphor sheet. Exhaustion The phosphor layer is scanned by the excitation light,
When the stimulable phosphor is excited and photoelectrically detects the emitted stimulant light, it is possible to generate biochemical analysis data with high resolution and high quantitativeness, while Since the management data including the data related to the time used as the standard for calculating the decay time of the radiation contained in the radiolabeled substance is recorded on the substrate of the biochemical analysis unit,
It becomes possible to easily record the management data in the biochemical analysis unit by using various recording methods such as printing and marking.

[0031] In another preferred aspect of the present invention, the biochemical analysis unit includes an absorptive substrate formed of an absorptive material, and the radiation is attenuated on at least one surface of the absorptive substrate. A substrate having a plurality of through-holes having a property is adhered, and a plurality of absorptive regions are formed by the absorptive substrate in the plurality of through-holes formed on the substrate, and the biochemical analysis is performed. It is configured to record the management data on the substrate of the operating unit.

According to another preferred embodiment of the invention,
The biochemical analysis unit has an absorptive substrate formed of an absorptive material, and has a property of attenuating radiation on at least one surface of the absorptive substrate, and a substrate having a plurality of through holes is closely attached thereto. A plurality of absorptive regions are formed by the absorptive substrates in the plurality of through holes formed in the substrate, and the hybridization device is configured to record management data on the substrate of the biochemical analysis unit. Therefore, it is possible to control the distance between the adsorbing regions adjacent to each other as desired, and therefore, the hybridization apparatus can detect the radioactivity of the specific binding substance contained in the adsorbing region of the biochemical analysis unit. After selectively hybridizing a biological substance labeled with a labeling substance, the stimulable phosphor layer formed on the stimulable phosphor sheet is removed. Exposure with a radioactive labeling substance contained in the absorptive region of the biochemical analysis unit, the stimulable phosphor layer of the stimulable phosphor sheet, scanned by excitation light, the stimulable phosphor is excited, By photoelectrically detecting the emitted photostimulable light, it is possible to generate highly quantitative data for biochemical analysis with high resolution, and at the same time, attenuate the radiation contained in the radiolabeled substance. Since the management data including the time-related data used as the reference for calculating the time is recorded on the substrate of the biochemical analysis unit, it can be easily recorded on the biochemical analysis unit using various recording methods such as printing and marking. Moreover, it becomes possible to record management data.

[0033] In a preferred aspect of the present invention, the management data is recorded as visible data on the substrate of the biochemical analysis unit.

According to a preferred embodiment of the present invention, management data is recorded as visible data on the substrate of the biochemical analysis unit.
The user reads the management data including the data related to the time, which is the standard for calculating the decay time of the radiation contained in the radiolabeled substance recorded on the substrate of the biochemical analysis unit, and uses it based on the read management data. In accordance with the radionuclide of the radiolabeled substance, the used biochemical analysis unit should be controlled to ensure that the level of radioactivity of the radiolabeled substance falls below a prescribed level, and It can be discarded after the level decays below a predetermined level, while the optical data reader is used to calculate the decay time of the radiation contained in the radiolabeled substance recorded on the substrate of the biochemical analysis unit. Radioactive substances used by reading the control data including the data on the reference time and based on the read control data According to the nuclide, automatically calculate the time when the level of radioactivity of the radiolabeled substance falls below a predetermined level, and depending on the time when the level of radioactivity of the radiolabeled substance falls below a predetermined level, By selecting the biochemical analysis unit, the used biochemical analysis unit can be managed reliably until the level of radioactivity of the radiolabeled substance falls below a predetermined level, and the radioactivity of the radiolabeled substance is emitted. It becomes possible to discard after the level of activity has decayed below a predetermined level.

In a preferred aspect of the present invention, a magnetic recording layer is formed on the substrate of the biochemical analysis unit, and the management data is magnetically recorded on the magnetic recording layer.

According to a preferred embodiment of the present invention, the magnetic recording layer is formed on the substrate of the biochemical analysis unit, and the management data is magnetically recorded on the magnetic recording layer. Using the reading device, read the management data including the data related to the time to be the reference for calculating the decay time of the radiation contained in the radiolabeled substance magnetically recorded on the substrate of the biochemical analysis unit, and read it as the read management data. Based on the nuclide of the radiolabeled substance used, automatically calculate the time when the radioactivity level of the radiolabeled substance falls below a predetermined level.
Depending on the time of decay of the radioactivity level of the radiolabeled substance,
By selecting the biochemical analysis unit, the used biochemical analysis unit can be managed reliably until the level of radioactivity of the radiolabeled substance falls below a predetermined level, and the radioactivity of the radiolabeled substance is emitted. It becomes possible to discard after the level of activity has decayed below a predetermined level.

In another preferred embodiment of the present invention, the biochemical analysis unit comprises an absorptive substrate formed of an absorptive material, and the plurality of absorptive regions are provided on the absorptive substrate. Alternatively, it is formed by dropping a solution containing a specific binding substance having a known characteristic, and recording the management data on the absorptive substrate of the biochemical analysis unit.

In a further preferred aspect of the present invention, the management data is recorded as visible data on the absorptive substrate of the biochemical analysis unit.

According to a further preferred aspect of the present invention, since the management data is recorded as visible data on the absorptive substrate of the biochemical analysis unit, the user can use it for biochemical analysis. Read the management data including the data related to the time to be the reference for calculating the decay time of the radiation contained in the radiolabeled substance recorded on the adsorptive substrate of the unit, and based on the read management data,
According to the nuclide of the radiolabeled substance used, ensure that the used biochemical analysis unit, until the level of radioactivity of the radiolabeled substance is attenuated below a predetermined level,
It can be disposed of after being controlled and the radioactivity level has decayed below a prescribed level, while it is included in the radiolabeled substance recorded on the absorptive substrate of the biochemical analysis unit using an optical data reader. Read the control data including the data related to the time to be used as the basis for calculating the decay time of the radiation to be stored, and based on the read control data, the radioactivity of the radiolabeled substance is automatically changed according to the nuclide of the radiolabeled substance used. Calculate the time at which the level decays below a predetermined level, and select the biochemical analysis unit according to the decay time of the radioactivity level of the radiolabeled substance, thereby disposing the used biochemical analysis unit, Make sure that the level of radioactivity of the radiolabeled substance is controlled until it falls below the prescribed level, and that the level of radioactivity decays below the prescribed level. It is possible to discarded after.

[0040] In a preferred aspect of the present invention, the management data includes data on a nuclide of the radiolabeled substance, in addition to data on a time serving as a reference for calculating a decay time of radiation contained in the radiolabeled substance. Contains.

According to a preferred embodiment of the present invention, the management data includes data on the nuclide of the radiolabeled substance in addition to the data on the reference time for calculating the decay time of the radiation contained in the radiolabeled substance. Since there,
By reading the management data, the radioactivity level of the radiolabeled substance is below the specified level, based on the data on the time to be the reference for calculating the decay time of the radiation contained in the radiolabeled substance and the data on the nuclide of the radiolabeled substance. It is possible to calculate the time until decay to, therefore, by selecting the used biochemical analysis unit according to the time when the level of radioactivity of the radiolabeled substance decays below a predetermined level, Manage the used biochemical analysis unit until the radioactivity level of the radiolabeled substance has decayed to below the prescribed level, and the radioactivity level of the radiolabeled substance decays to below the prescribed level. After that, it becomes possible to discard.

[0042] In a further preferred aspect of the present invention, the biochemical analysis is performed on the basis of data on a time serving as a reference for calculating a decay time of radiation contained in the radiolabeled substance and data on a nuclide of the radiolabeled substance. It is configured to determine the disposal time of the use unit and to select and manage the biochemical analysis unit according to the disposal time.

According to a further preferred embodiment of the present invention, the unit for biochemical analysis is based on the data relating to the time serving as the reference for calculating the decay time of the radiation contained in the radiolabeled substance and the data relating to the nuclide of the radiolabeled substance. The biochemical analysis unit is configured to be selected and managed according to the disposal time of the biochemical analysis unit according to the disposal time. It can be controlled until the activity level decays below a predetermined level and then discarded after the radioactivity level of the radiolabeled substance decays below a predetermined level.

The above-mentioned object of the present invention is also a system for managing a biochemical analysis unit in which a plurality of absorptive regions containing a specific binding substance having a known structure or property are formed separately from each other, For biochemical analysis, characterized by comprising a management data recording device for recording management data including data relating to time as a reference for calculating the decay time of radiation contained in the radiolabeled substance in the biochemical analysis unit. Achieved by the unit management system.

According to the present invention, the biochemical analysis unit management system is provided with a biochemical analysis unit in which a plurality of absorptive regions containing specific binding substances having known structures or characteristics are formed apart from each other. Is a system for managing
Since the management data recording device that records the management data including the data related to the time used as the reference for calculating the decay time of the radiation contained in the radiolabeled substance in the biochemical analysis unit is used, Based on the data related to the time used as the reference for calculating the decay time of the radiation contained in the radiolabeled substance recorded in the chemical analysis unit, the used biochemical analysis unit is replaced according to the nuclide of the radiolabeled substance used. Therefore, it is possible to manage until the radioactivity level of the radiolabeled substance decays to a predetermined level or lower, and to discard it after the radioactivity level of the radiolabeled substance decays to a predetermined level or lower.

[0046] In a preferred embodiment of the present invention, the biochemical analysis unit management system further comprises a radiolabeled substance as a specific binding substance contained in the plurality of absorptive regions of the biochemical analysis unit. A hybridization device for selectively hybridizing a substance derived from a living body labeled by is provided with the management device, and the hybridization device is provided with the management data recording device.

According to a preferred embodiment of the present invention, the management system for the biochemical analysis unit further comprises using a radiolabeled substance for the specific binding substance contained in the plurality of adsorptive regions of the biochemical analysis unit. Since a hybridization device for selectively hybridizing a labeled substance derived from a living body is provided, and the hybridization device is provided with a management data recording device, management of the hybridization device is performed when performing hybridization. The data recorder records the data on the time, which is the standard for calculating the decay time of the radiation contained in the radiolabeled substance, in the biochemical analysis unit, and the radiation contained in the radiolabeled substance recorded in the biochemical analysis unit. Based on the time data that is the standard for calculating the decay time of According to the radionuclide of the radiolabeled substance, the used biochemical analysis unit should be controlled and the radioactivity of the radiolabeled substance should be controlled until the radioactivity level of the radiolabeled substance falls below a predetermined level. Can be discarded after the level of has decayed below a predetermined level.

[0048] In a preferred aspect of the present invention, the data on the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes data on the date and time at which the hybridization is carried out.

According to a preferred embodiment of the present invention, it is used for biochemical analysis according to the nuclide of the radiolabeled substance used, based on the date and time of the hybridization recorded in the biochemical analysis unit. The unit for biochemical analysis performed must be managed until the level of radioactivity of the radiolabeled substance has decayed below a prescribed level, and after the level of radioactivity of the radiolabeled substance has decayed below a prescribed level. , Can be discarded.

[0050] In another preferred embodiment of the present invention, the data on the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes the data on the day on which the hybridization is carried out.

According to another preferred embodiment of the invention,
Based on the data recorded on the biochemical analysis unit regarding the date when the hybridization is performed, ensure that the biochemical analysis unit used for biochemical analysis is radioactive according to the radionuclide nuclide used. It is possible to manage until the radioactivity level of the labeling substance decays below a predetermined level, and to discard it after the radioactivity level of the radiolabeling substance decays below a predetermined level.

In a preferred embodiment of the present invention, the management system for the biochemical analysis unit further comprises a specific binding substance having a known structure or property and at least a radiolabeling substance, and the specific binding substance is labeled with the specific binding substance. , Selectively, a biochemical analysis unit in which a plurality of absorptive regions containing hybridized substances of biological origin are formed,
A support is provided, and the support is superposed on a stimulable phosphor sheet having a stimulable phosphor layer containing a stimulable phosphor, and the plurality of absorptive regions of the biochemical analysis unit. An exposure device is provided for exposing the stimulable phosphor layer of the stimulable phosphor sheet with a radioactive labeling substance selectively contained in the exposure device, and the exposure device is provided with the management data recording device.

According to a preferred embodiment of the present invention, the management system of the biochemical analysis unit further comprises a specific binding substance having a known structure or property, and at least a radiolabeling substance to label the specific binding substance. , A biochemical analysis unit in which a plurality of absorptive regions containing a hybridized substance derived from a living body are selectively provided, and a support is provided, and the support contains a stimulable phosphor. The stimulable fluorescence of the stimulable phosphor sheet is superposed on the stimulable phosphor sheet on which the phosphor layer is formed by the radioactive labeling substance selectively contained in the plurality of absorptive regions of the biochemical analysis unit. An exposure device for exposing the body layer is provided, and the exposure device is
Since the management data recording device is provided, when the exposure operation is executed, the management data recording device of the exposure device
Data on the time used as the basis for calculating the decay time of the radiation contained in the radiolabeled substance is recorded in the biochemical analysis unit, and the decay time of the radiation contained in the radiolabeled substance recorded in the biochemical analysis unit is calculated. Based on the standard time data, the used biochemical analysis unit will be surely attenuated to the radioactivity level below the specified level according to the radionuclide used. It becomes possible to manage and to discard after the radioactivity level of the radiolabeled substance has decayed below a predetermined level.

In a further preferred aspect of the present invention, the data regarding the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes data regarding the date and time when the exposure operation is performed.

According to a further preferred embodiment of the present invention, the biochemical analysis is carried out according to the radionuclide nuclide used based on the date and time of the exposure operation recorded in the biochemical analysis unit. The used biochemical analysis unit was managed until the level of radioactivity of the radiolabeled substance decreased to a predetermined level or lower, and the radioactivity level of the radiolabeled substance decreased to a predetermined level or lower. It can later be discarded.

In another preferred embodiment of the present invention, the data on the time serving as a reference for calculating the decay time of the radiation contained in the radio-labeled substance includes the data on the day on which the exposure operation is performed.

According to another preferred embodiment of the present invention,
Based on the data regarding the date on which the exposure operation is performed,
Depending on the nuclide of the radiolabeled substance used, the biochemical analysis unit used for biochemical analysis should be controlled and the radioactivity of the radiolabeled substance should be controlled until the radioactivity level falls below a prescribed level. After the radioactivity level of the labeling substance decays below a predetermined level, it can be discarded.

In a preferred embodiment of the present invention, the data on the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes data on the date and time when the radiolabeled substance was produced.

According to a preferred embodiment of the present invention, since the data on the date and time when the radiolabeled substance is produced is recorded in the biochemical analysis unit, the date and time when the radiolabeled substance recorded in the biochemical analysis unit is produced. According to the radionuclide nuclide used, the unit for biochemical analysis used for biochemical analysis can be managed more reliably until the radioactivity level of the radiolabeled substance decays below a prescribed level. However, after the radioactivity level of the radio-labeled substance is attenuated below a predetermined level, it becomes possible to dispose of it.

In another preferred embodiment of the present invention, the data on the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes the data on the date when the radiolabeled substance was produced.

According to another preferred embodiment of the present invention,
Since the data regarding the date and time when the radiolabeled substance was generated is recorded in the biochemical analysis unit, the data regarding the date when the radiolabeled substance was recorded recorded in the biochemical analysis unit was used according to the nuclide of the radiolabeled substance used. Biochemical analysis unit used for biochemical analysis,
More surely, it is possible to manage until the radioactivity level of the radiolabeled substance falls below a predetermined level, and to discard it after the radioactivity level of the radiolabeled substance decays below a predetermined level. .

[0062] In a preferred aspect of the present invention, the biochemical analysis unit includes a substrate having a plurality of holes formed apart from each other, and the plurality of absorptive regions are formed on the substrate. The plurality of holes are filled with an adsorbent material, and the adsorbent material filled in the plurality of holes is formed by containing the specific binding substance. On the board of the analysis unit,
It is configured to record the management data.

According to a preferred embodiment of the present invention, the biochemical analysis unit includes a substrate in which a plurality of holes are formed apart from each other, and a plurality of absorptive regions are formed in the substrate. The pores are filled with an adsorbent material, and the adsorbent material filled in the plurality of pores is formed by containing a specific binding substance, and the management data recording device is formed on the substrate of the biochemical analysis unit. Since it is configured to record the management data, it is possible to control the interval between the adsorbing regions adjacent to each other as desired, and therefore, the hybridization device can control the adsorbing regions of the biochemical analysis unit. The specific binding substance contained is selectively hybridized with a substance of biological origin labeled with a radioactive labeling substance, and then the stimulable phosphor layer formed on the stimulable phosphor sheet is produced. The radioactive labeling substance contained in the absorptive region of the analysis unit exposes the stimulable phosphor layer of the stimulable phosphor sheet to light exposure, and the stimulable phosphor is excited and emitted. By photoelectrically detecting the stimulated emission, it becomes possible to generate biochemical analysis data with high resolution and excellent quantitativeness.
Since the control data including the time-related data used as the reference for calculating the decay time of the radiation contained in the radiolabeled substance is recorded on the substrate of the biochemical analysis unit, various recording methods such as printing and engraving are used. It becomes possible to easily record the management data in the biochemical analysis unit.

In another preferred aspect of the present invention, the biochemical analysis unit includes an absorptive substrate formed of an absorptive material, and at least one surface of the absorptive substrate attenuates radiation. A substrate having a plurality of through holes is adhered to the substrate, and a plurality of absorptive regions are formed by the absorptive substrate in the plurality of through holes formed on the substrate, and the management data recording is performed. An apparatus is configured to record the management data on the substrate of the biochemical analysis unit.

According to another preferred embodiment of the invention,
The biochemical analysis unit has an absorptive substrate formed of an absorptive material, and has a property of attenuating radiation on at least one surface of the absorptive substrate, and a substrate having a plurality of through holes is closely attached thereto. Then, a plurality of absorptive regions are formed by the absorptive substrates in the plurality of through holes formed in the substrate, and the management data recording device is configured to record the management data on the substrate of the biochemical analysis unit. Therefore, it is possible to control the interval between the adsorbing regions adjacent to each other as desired, and therefore, the specific binding substance contained in the adsorbing region of the biochemical analysis unit can be controlled by the hybridization device. After selectively hybridizing a biological substance labeled with a radioactive labeling substance, the stimulable phosphor layer formed on the stimulable phosphor sheet is used for biochemical analysis. The stimulable phosphor layer of the stimulable phosphor sheet is scanned by excitation light by exposure with a radioactive labeling substance contained in the absorptive region of the knit, and the stimulable phosphor is excited and emitted. By photoelectrically detecting light, it is possible to generate highly accurate biochemical analysis data with high resolution, while calculating the decay time of the radiation contained in the radiolabeled substance. Since the management data including the reference time data is recorded on the substrate of the biochemical analysis unit, printing, marking, etc.
It becomes possible to easily record the management data in the biochemical analysis unit by using various recording methods.

In a preferred aspect of the present invention, the management data recording device is configured to record the management data as visible data on the substrate of the biochemical analysis unit.

According to a preferred embodiment of the present invention, since the management data recording device is configured to record the management data as visible data on the substrate of the biochemical analysis unit, the user can The radiolabeled substance used was read based on the read control data by reading the control data including the data related to the time used as the reference for calculating the decay time of the radiation contained in the radiolabeled substance recorded on the substrate of the chemical analysis unit. In accordance with the nuclide of, the used biochemical analysis unit should be controlled until the radioactivity level of the radiolabeled substance falls below a prescribed level, and the radioactivity level of the radiolabeled substance shall be controlled to the prescribed level. Can be discarded after decaying below the level, while
Using the optical data reader, read the management data including the data related to the time to be the reference for calculating the decay time of the radiation contained in the radiolabeled substance recorded on the substrate of the biochemical analysis unit, and read the management data According to the radionuclide of the radiolabeled substance used, the time at which the radioactivity level of the radiolabeled substance decays below a predetermined level is calculated automatically, and the radioactivity level of the radiolabeled substance is determined according to the By selecting the biochemical analysis unit according to the time when it decays below the level, the used biochemical analysis unit is reliably attenuated to a level below the radioactivity level of the radiolabeled substance. It becomes possible to manage and to discard after the radioactivity level of the radiolabeled substance has decayed below a predetermined level.

In another preferred embodiment of the present invention, a magnetic recording layer is formed on the substrate of the biochemical analysis unit, and the management data recording device stores the management data in the magnetic recording layer. It is configured for magnetic recording.

According to another preferred embodiment of the present invention,
A magnetic recording layer is formed on the substrate of the biochemical analysis unit, and the management data recording device is configured to magnetically record the management data on the magnetic recording layer. Radioactive labels magnetically recorded on the substrate of the biochemical analysis unit by recording management data including time-related data that is used as the reference for calculating the decay time of the radiation contained in the radiolabeled substance. Radioactive substance is automatically read according to the nuclide of the radiolabeled substance that is read based on the read control data, including the data related to the time used as the standard for calculating the decay time of the radiation contained in the substance. Calculate the time when the radioactivity level of the radioactivity decays below a predetermined level, and generate the radioactivity according to the time when the radioactivity level of the radiolabeled substance decays. By selecting the analysis unit, the used of the biochemical analysis unit, reliably,
It becomes possible to manage until the level of radioactivity of the radiolabeled substance falls below a predetermined level, and to discard it after the level of radioactivity of the radiolabeled substance decays below a predetermined level.

[0070] In another preferred aspect of the present invention, the biochemical analysis unit includes an absorptive substrate formed of an absorptive material, and the plurality of absorptive regions are provided on the absorptive substrate. Alternatively, the management data recording device is formed by dropping a solution containing a specific binding substance having a known property, and the management data recording device is configured to record the management data on the absorptive substrate of the biochemical analysis unit. There is.

[0071] In a further preferred aspect of the present invention, the management data recording device is configured to record the management data as visible data on the absorptive substrate of the biochemical analysis unit. .

According to a further preferred aspect of the present invention, the management data recording device is configured to record the management data as visible data on the absorptive substrate of the biochemical analysis unit. Read the management data including the time-related data that is the reference for calculating the decay time of the radiation contained in the radiolabeled substance recorded on the adsorptive substrate of the biochemical analysis unit, and use it based on the read management data. According to the nuclide of the radiolabeled substance, used biochemical analysis unit,
Be sure to manage until the radioactivity level of the radiolabel has decayed below a predetermined level, and then discard it after the radioactivity level of the radiolabel has decayed below a predetermined level, while With a data reader,
Read the management data including the data related to the time to be the reference for calculating the decay time of the radiation contained in the radiolabeled substance recorded on the adsorptive substrate of the biochemical analysis unit,
Based on the read control data, the time when the radioactivity level of the radiolabeled substance decays below a predetermined level is automatically calculated according to the radionuclide of the radiolabeled substance used to determine the radioactivity of the radiolabeled substance. By selecting the biochemical analysis unit according to the level decay time,
Manage the used biochemical analysis unit until the radioactivity level of the radiolabeled substance has decayed to below the prescribed level, and the radioactivity level of the radiolabeled substance has decayed to below the prescribed level. It can be discarded later.

[0073] In a preferred aspect of the present invention, the management data includes data on a nuclide of the radiolabeled substance in addition to data on a time serving as a reference for calculating a decay time of radiation contained in the radiolabeled substance. Contains.

According to a preferred embodiment of the present invention, the management data includes data on the radionuclide nuclide in addition to the data on the reference time for calculating the decay time of the radiation contained in the radiolabeled substance. Since there,
By reading the management data, the radioactivity level of the radiolabeled substance is below the specified level based on the data on the time to be the standard for calculating the decay time of the radiation contained in the radiolabeled substance and the data on the nuclide of the radiolabeled substance. It is possible to calculate the time until decay to, therefore, by selecting the used biochemical analysis unit according to the time when the level of radioactivity of the radiolabeled substance falls below a predetermined level, Manage the used biochemical analysis unit until the radioactivity level of the radiolabeled substance has decayed to below the prescribed level, and the radioactivity level of the radiolabeled substance decays to below the prescribed level. After that, it becomes possible to discard.

[0075] In a further preferred aspect of the present invention, the biochemical analysis unit management system further comprises:
Based on the data on the time to be the reference for calculating the decay time of the radiation contained in the radiolabeled substance and the data on the radionuclide of the radiolabeled substance, the disposal time of the biochemical analysis unit is determined, and Therefore, a biochemical analysis unit selection device is provided which is configured to select and manage the biochemical analysis unit.

According to a further preferred embodiment of the present invention, the biochemical analysis unit management system further comprises:
The disposal time of the biochemical analysis unit is determined based on the data on the time used as the standard for calculating the decay time of the radiation contained in the radiolabeled substance and the data on the nuclide of the radiolabeled substance, and the biochemistry Since it has a biochemical analysis unit selection device configured to select and manage analysis units, used biochemical analysis units can be disposed according to the time when they can be discarded.
It can be automatically sorted and controlled, and therefore, the used biochemical analysis unit can be controlled to ensure that the level of radioactivity of the radiolabeled substance falls below a predetermined level. It becomes possible to dispose after the radioactivity level of the radio-labeled substance is attenuated below a predetermined level.

In a preferred aspect of the present invention, the substrate of the biochemical analysis unit has a property of attenuating radiation.

According to a preferred embodiment of the present invention, since the substrate of the biochemical analysis unit has a property of attenuating radiation, the substrate of the biochemical analysis unit is
Even if a plurality of absorptive regions are formed by forming a plurality of pores at high density, a plurality of absorptive regions of the biochemical analysis unit can be specifically bound to a substance of biological origin, and, A specific binding substance with a known base sequence, base length, composition, etc. is dropped and adsorbed, and the specific binding substance adsorbed in a plurality of absorptive regions is labeled with a radiolabeling substance from a living body. The substance is specifically bound, selectively labeled, the biochemical analysis unit and the stimulable phosphor sheet are overlapped, and the radiolabeled substance selectively contained in a plurality of adsorptive regions, When exposing the stimulable phosphor layer formed on the support of the stimulable phosphor sheet, the electron beam (β-ray) emitted from the radiolabel substance contained in each adsorptive region is biochemical. Effective to scatter in the substrate of the analysis unit Can be prevented, and therefore,
The electron beam (β-ray) emitted from the radiolabeled substance contained in each adsorptive region is selectively made incident on the region of the corresponding stimulable phosphor layer to generate the corresponding stimulable phosphor. Since it becomes possible to expose only the region of the layer, the photostimulable phosphor layer exposed by the radioactive labeling substance is scanned with excitation light, and the photostimulable light emitted from the photostimulable phosphor layer is photoelectrically converted. It is possible to generate data for biochemical analysis with high resolution and excellent quantification by detecting
On the other hand, even when a plurality of through-holes are formed on the substrate of the biochemical analysis unit at a high density and a plurality of absorptive regions are formed at a high density, the plurality of absorptive regions of the biochemical analysis unit are , A specific binding substance that can be specifically bound to a substance derived from a living body and that has a known base sequence, base length, composition, etc., is dropped, adsorbed, and adsorbed to multiple absorptive regions A biologically-derived substance labeled with a radiolabeling substance is specifically bound to the selectively binding substance, and selectively labeled, and the biochemical analysis unit and the stimulable phosphor sheet are overlapped to form a plurality of substances. When the stimulable phosphor layer formed on the support of the stimulable phosphor sheet is exposed by the radioactive labeling substance selectively contained in the absorptive region, the radioactive label contained in each absorptive region The electron beam (β-ray) emitted from the substance is It can be effectively prevented that scattering in the substrate of the unit for academic analysis, therefore,
The electron beam (β-ray) emitted from the radiolabeled substance contained in each adsorptive region is selectively made incident on the region of the corresponding stimulable phosphor layer to generate the corresponding stimulable phosphor. Since it becomes possible to expose only the region of the layer, the photostimulable phosphor layer exposed by the radioactive labeling substance is scanned with excitation light, and the photostimulable light emitted from the photostimulable phosphor layer is photoelectrically converted. It is possible to generate data for biochemical analysis with high resolution and excellent quantification by performing the detection.

In a preferred embodiment of the present invention, when the substrate of the biochemical analysis unit is exposed to radiation by a distance equal to the distance between the adjacent absorptive regions, Energy of 1/5
It has the following property of damping.

In a further preferred aspect of the present invention, when the substrate of the biochemical analysis unit transmits radiation through the substrate by a distance equal to the distance between the adjacent absorptive regions, The energy of radiation
It has the property of being attenuated to 1/10 or less.

In a further preferred aspect of the present invention, when the substrate of the biochemical analysis unit transmits radiation through the substrate by a distance equal to the distance between the adsorbing regions adjacent to each other, The energy of radiation
It has the property of being attenuated to 1/50 or less.

In a further preferred aspect of the present invention, when radiation is transmitted through the substrate by a distance equal to the distance between the absorptive regions of the substrate of the biochemical analysis unit, The energy of radiation
It has the property of being attenuated to 1/100 or less.

In a further preferred aspect of the present invention, when the substrate of the biochemical analysis unit has radiation transmitted through the substrate by a distance equal to the distance between the adjacent absorptive regions, The energy of radiation
It has the property of being attenuated to 1/500 or less.

[0084] In a further preferred aspect of the present invention, when the substrate of the biochemical analysis unit has radiation transmitted through the substrate by a distance equal to the distance between the adsorbing regions adjacent to each other, The energy of radiation
It has the property of being attenuated to 1/1000 or less.

In a preferred aspect of the present invention, 10 or more absorptive regions are formed on the substrate of the biochemical analysis unit.

In a further preferred aspect of the present invention, the substrate of the biochemical analysis unit is formed with 50 or more absorptive regions.

In a further preferred aspect of the present invention, the substrate of the biochemical analysis unit is formed with 100 or more absorptive regions.

In a further preferred aspect of the present invention, the substrate of the biochemical analysis unit is formed with 500 or more absorptive regions.

In a further preferred aspect of the present invention, the substrate of the biochemical analysis unit is provided with 1000
The above-mentioned absorptive region is formed.

In a further preferred aspect of the present invention, the substrate of the biochemical analysis unit is provided with 5000
The above-mentioned absorptive region is formed.

In a further preferred aspect of the present invention, the substrate of the biochemical analysis unit is provided with 1000
Zero or more absorptive regions are formed.

In a further preferred aspect of the present invention, the substrate of the biochemical analysis unit is provided with 5000
Zero or more absorptive regions are formed.

In a further preferred aspect of the present invention, the substrate of the biochemical analysis unit is provided with 1000
00 or more absorptive regions are formed.

[0094] In a preferred aspect of the present invention, each of the plurality of absorptive regions formed on the substrate of the biochemical analysis unit has a size of less than 5 mm 2.

In a further preferred aspect of the present invention, each of the plurality of absorptive regions formed on the substrate of the biochemical analysis unit has a size of less than 1 mm 2.

In a further preferred aspect of the present invention, each of the plurality of absorptive regions formed on the substrate of the biochemical analysis unit has a size of less than 0.5 mm 2.

In a further preferred aspect of the present invention, each of the plurality of absorptive regions formed on the substrate of the biochemical analysis unit has a size of less than 0.1 mm 2.

In a further preferred aspect of the present invention, each of the plurality of absorptive regions formed on the substrate of the biochemical analysis unit has a size of less than 0.05 mm 2.

In a further preferred aspect of the present invention, each of the plurality of absorptive regions formed on the substrate of the biochemical analysis unit has a size of less than 0.01 mm 2.

[0100] In a preferred aspect of the present invention, the plurality of absorptive regions are provided on the substrate of the biochemical analysis unit at a density of 10 or more per cm 2.
Has been formed.

[0101] In a further preferred aspect of the present invention, the plurality of absorptive regions are formed on the substrate of the biochemical analysis unit at a density of 50 or more per cm 2.

In a further preferred aspect of the present invention, the plurality of absorptive regions are formed on the substrate of the biochemical analysis unit at a density of 100 or more per cm 2.

[0103] In a further preferred aspect of the present invention, the plurality of absorptive regions are formed in the substrate of the biochemical analysis unit at a density of 500 or more per cm 2.

[0104] In a further preferred aspect of the present invention, the plurality of absorptive regions are formed in the substrate of the biochemical analysis unit at a density of 1,000 or more per cm 2.

[0105] In a further preferred aspect of the present invention, the plurality of absorptive regions are formed in the substrate of the biochemical analysis unit at a density of 5000 or more per cm 2.

[0106] In a further preferred aspect of the present invention, the plurality of absorptive regions are formed in the substrate of the biochemical analysis unit at a density of 10,000 or more per cm 2.

[0107] In a further preferred aspect of the present invention, the plurality of absorptive regions are formed in the substrate of the biochemical analysis unit at a density of 50000 pieces / square centimeter or more.

[0108] In a further preferred aspect of the present invention, the plurality of absorptive regions are formed in the substrate of the biochemical analysis unit at a density of 100,000 per square centimeter or more.

In the present invention, the material for forming the substrate of the biochemical analysis unit preferably has a property of attenuating radiation, but it is not particularly limited, and it is an inorganic compound material or an organic compound. Any of the compound materials can be used, and metallic materials, ceramic materials or plastic materials are preferably used.

In the present invention, examples of the inorganic compound material that can be used to form the substrate of the biochemical analysis unit include gold, silver, copper, zinc, aluminum, titanium, tantalum, chromium, iron, Metals such as nickel, cobalt, lead, tin and selenium; brass, stainless steel,
Alloys such as bronze; silicon materials such as silicon, amorphous silicon, glass, quartz, silicon carbide and silicon nitride;
Examples thereof include metal oxides such as aluminum oxide, magnesium oxide and zirconium oxide; and inorganic salts such as tungsten carbide, calcium carbonate, calcium sulfate, hydroxyapatite and gallium arsenide. These may have any structure in a polycrystalline sintered body such as single crystal, amorphous, or ceramic.

In the present invention, a polymer compound is preferably used as the organic compound material that can be used for forming the substrate of the biochemical analysis unit, and as the polymer compound that can be preferably used, For example, polyolefins such as polyethylene and polypropylene; acrylic resins such as polymethylmethacrylate and butylacrylate / methylmethacrylate copolymers;
Polyacrylonitrile; Polyvinyl chloride; Polyvinylidene chloride; Polyvinylidene fluoride; Polytetrafluoroethylene; Polychlorotrifluoroethylene; Polycarbonate; Polyesters such as polyethylene naphthalate and polyethylene terephthalate; Nylon 6, Nylon 6,6, Nylon 4,10 Nylon such as; Polyimide; Polysulfone; Polyphenylene sulfide; Silicon resin such as polydiphenylsiloxane; Phenolic resin such as novolac; Epoxy resin; Polyurethane; Polystyrene; Butadiene-styrene copolymer; Cellulose, Cellulose acetate, Nitrocellulose, Starch, Alginic acid Polysaccharides such as calcium and hydroxypropyl methylcellulose; chitin; chitosan; sumacum; gelatin, collagen, kerula Polyamides such emissions and the like can be mentioned copolymers of these polymeric compounds.
These may be a composite material, if necessary, can be filled with metal oxide particles or glass fiber,
It is also possible to blend and use an organic compound material.

Generally, the larger the specific gravity is, the higher the radiation attenuating ability is. Therefore, the substrate of the biochemical analysis unit is preferably formed of a compound material or a composite material having a specific gravity of 1.0 g / cm ³ or more, Specific gravity is 1.5g / c
It is particularly preferable that it is formed of a compound material or a composite material of m ³ or more and 23 g / cm ³ or less.

In the present invention, a porous material or a fibrous material is preferably used as the absorptive material for forming the absorptive region or the absorptive substrate of the biochemical analysis unit. The absorptive region or the absorptive substrate can be formed by using the porous material and the fiber material together.

In the present invention, the porous material used to form the adsorptive region of the biochemical analysis unit or the adsorptive substrate may be either an organic material or an inorganic material, or an organic / inorganic composite. .

In the present invention, the organic porous material used to form the absorptive region or the absorptive substrate of the biochemical analysis unit is not particularly limited, but is a carbon material such as activated carbon or a membrane. A material capable of forming a filter is preferably used. Specifically, nylons such as nylon 6, nylon 6,6, nylon 4,10; nitrocellulose, cellulose acetate,
Cellulose derivatives such as cellulose acetate butyrate; collagen; alginic acid, calcium alginate, alginic acid /
Alginic acids such as polylysine polyion complex; polyolefins such as polyethylene and polypropylene; polyvinyl chloride; polyvinylidene chloride; polyfluoride such as polyvinylidene fluoride and polytetrafluoride; and copolymers or composites thereof. .

In the present invention, the inorganic porous material used for forming the absorptive region or the absorptive substrate of the biochemical analysis unit is not particularly limited, but preferably, for example, platinum, Examples thereof include metals such as gold, iron, silver, nickel and aluminum; metal oxides such as alumina, silica, titania and zeolite; metal salts such as hydroxyapatite and calcium sulfate, and complexes thereof.

In the present invention, the fibrous material used for forming the absorptive region or the absorptive substrate of the biochemical analysis unit is not particularly limited, but preferably, for example, nylon 6 or nylon. Nylons such as 6,6 and nylon 4,10, nitrocellulose,
Examples thereof include cellulose derivatives such as cellulose acetate and cellulose butyrate.

In the present invention, the absorptive region of the biochemical analysis unit is subjected to oxidation treatment such as electrolytic treatment, plasma treatment and arc discharge; primer treatment using silane coupling agent, titanium coupling agent and the like; surfactant. It can also be formed by surface treatment such as treatment.

[0119]

Preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

FIG. 1 is a schematic perspective view of a biochemical analysis unit managed by a biochemical analysis unit management system according to a preferred embodiment of the present invention.

As shown in FIG. 1, the biochemical analysis unit 1 according to this embodiment comprises a substrate 2 formed of aluminum and having a large number of substantially circular through holes 3 formed therein at a high density. Nylon 6 is filled inside the large number of through holes 3 to form a large number of dot-shaped absorptive regions 4
Are formed.

On the substrate 2 of the biochemical analysis unit 1 according to this embodiment, a magnetic recording layer 5 is formed by a magnetic recording medium.
Are formed, and when the biochemical analysis unit 1 is shipped, the ID data unique to each biochemical analysis unit 1 is written in the magnetic recording layer 5, and the biochemical analysis unit 1 is Each time it is used for hybridization, the hybridization device described below used the date and time of hybridization, the number of times of hybridization, and when a radioactive labeling substance was used as the labeling substance, the radioactive labeling substance was used. The radio-labeled data indicating the facts and the data related to the hybridization of the radio-labeled substance nuclide are written in the magnetic recording layer 5.

Although not shown exactly in FIG. 1, in the present embodiment, approximately 500 through-holes 3 each having a substantially circular shape having a size of about 0.01 square millimeter of about 10,000 are provided.
Substrate 2 regularly with a density of 0 pieces / cm 2.
Is formed in. The absorptive region 4 has a large number of through holes 3 so that its surface is located at the same height as the surface of the substrate 2.
Nylon 6 is filled inside and formed.

FIG. 2 is a schematic front view of the spotting device.

In the biochemical analysis, as shown in FIG. 2, in a large number of absorptive regions 4 regularly formed in the biochemical analysis unit 1, for example, a base sequence as a specific binding substance is used. Multiple known different cDNAs
Are dropped using a spotting device.

As shown in FIG. 2, the spotting device comprises an injector 7 and a CCD camera 8 for injecting a solution of a specific binding substance toward the biochemical analysis unit 1.
While observing the tip portion of the injector 7 and the through hole 3 to which the cDNA is dropped by the CCD camera 8 with the spotting head 9 provided with, the tip portion of the injector 7 and the through hole 3 to which the cDNA is dropped The cDNA is configured to be dropped from the injector 7 when the center of the is matched, so that the cDNA can be dropped accurately to the absorptive region 4 formed in the large number of through holes 3. Guaranteed.

FIG. 3 is a schematic side view of a hybridization apparatus constituting a management system for a biochemical analysis unit according to a preferred embodiment of the present invention.

As shown in FIG. 3, the hybridization apparatus 10 includes a cartridge loading section 12 for loading the biochemical analysis unit 1 into the cartridge 11, and the biochemical analysis unit 1 in the cartridge loading section 12. A pretreatment liquid, a hybridization solution, a probe solution containing a substance derived from a living body labeled with a labeling substance, and a washing solution are stored in a cartridge 11 housed therein.
A cartridge 11 in which a solution injecting section 13 for selectively injecting and a biochemical analysis unit 1 are housed, and a pretreatment solution, a hybridization solution, a solution obtained by adding a probe solution to the hybridization solution, or a washing solution is injected. The reaction unit 14 that applies vibration and the cartridge 11
From the above, a probe solution is added to the pretreatment solution and the hybridization solution, the prepared solution or the washing solution is extracted, and the biochemical analysis unit take-out section 15 for taking out the biochemical analysis unit 1 is provided.

Although not shown in FIG. 3, the hybridization apparatus 10 includes a temperature controller,
The inside of the hybridization device 10 is controlled within a predetermined temperature range. FIG. 4 is a schematic perspective view of the cartridge 11.

As shown in FIG. 4, the cartridge 11
Is equipped with a casing 11a and a lid 11b, and a pretreatment liquid, a hybridization solution, a probe solution and a washing solution are injected into the cartridge 11 into the lid 11b,
A solution injection / withdrawal port 11c that can be withdrawn is formed.

As shown in FIG. 3, the cartridge loading section 12 of the hybridization apparatus 10 has the first endless belt 16a on which the biochemical analysis unit 1 is set and the first endless belt 16a. ,
In FIG. 3, a pair of pulleys 16b and 16c that are selectively rotatable clockwise and counterclockwise and a first
Read head 17 for reading the data recorded on the magnetic recording layer 5 of the biochemical analysis unit 1 set on the endless belt 16a, and magnetic recording for writing the data on the magnetic recording layer 5 of the biochemical analysis unit 1. Head 18
And a loading mechanism 19 for opening and closing the lid 11b of the cartridge 11 to load the biochemical analysis unit 1 into the cartridge 11, and a second endless belt for transporting the cartridge 11 loaded with the biochemical analysis unit 1. 20a
And a pair of pulleys 20b and 20c around which the second endless belt 20a is wound.

Further, as shown in FIG. 3, the solution injecting section 13 of the hybridization apparatus 10 is connected to the second endless belt 20a of the cartridge loading section 12 from the second endless belt 20a.
Third endless belt 2 for receiving the cartridge 11
1a, a pair of pulleys 21b and 21c around which the third endless belt 21a is wound, and a pretreatment liquid for solution injection /
A pretreatment liquid injection pin 22 for injecting into the cartridge 11 located at the solution injection position via the extraction port 11c;
The hybridization solution injection pin 23 for injecting the hybridization solution into the cartridge 11 located at the solution injection position via the solution injection / extraction port 11c and the probe solution for the solution injection / extraction port 11c.
Via the probe injection pin 24, which is injected into the cartridge 11 located at the solution injection position and is added to the hybridization solution, and the cleaning solution, is located at the solution injection position via the solution injection / extraction port 11c. A cleaning solution injection pin 25 for injecting into the inside 11 is provided.

Here, the pair of pulleys 21b and 21c are
A motor (not shown) is configured to be selectively rotatable clockwise and counterclockwise in FIG.

Moreover, as shown in FIG. 3, the pretreatment liquid injection pin 22 and the hybridization solution injection pin 2
3, the probe solution injection pin 24 and the cleaning solution injection pin 25 are fixed to the solution pin head 26, and the solution pin head 26 is moved by a motor (not shown) along a pair of rails (not shown). It is configured to be possible.

As shown in FIG. 3, the reaction section 14 of the hybridization apparatus 10 is the third section of the solution injection section 13.
3, the fourth endless belt 27a and the fourth endless belt 27a, which receive the cartridge 11 from the endless belt 21a and transfer the cartridge 11 to the third endless belt 21a of the solution injecting section 13, are wound. At clockwise and counterclockwise,
A pair of selectively rotatable pulleys 27b and 27c and a vibration table 28 that vibrates the fourth endless belt 27a are provided.

Further, as shown in FIG. 3, the biochemical analysis unit take-out section 15 of the hybridization device 10 is provided with a fourth endless belt 27 of the reaction section 14.
The cartridge 11 is received from a and the cartridge 1
The fifth endless belt 29a for delivering 1 to the fourth endless belt 27a of the reaction unit 14 and the fifth endless belt 29a are wound, and selectively rotate clockwise and counterclockwise in FIG. Via a pair of rotatable pulleys 29b, 29c, a radiation sensor 30 for detecting the concentration of the radioactive labeling substance contained in the cleaning solution in the cartridge 11, and a solution injection / extraction port 11c,
A solution extracting pin 31 for extracting a prepared solution or a washing solution by adding a probe solution to the pretreatment solution and the hybridization solution from the inside of the cartridge 11.
Then, a lid 11b of the cartridge 11 is opened and the biochemical analysis unit 1 is taken out from the cartridge 11 and a biochemical analysis unit takeout mechanism 32 is provided.

FIG. 5 is a block diagram of a control system, a detection system, a drive system, an input system and a display system of the hybridization apparatus 10 which constitutes the management system of the biochemical analysis unit according to the preferred embodiment of the present invention. .

As shown in FIG. 5, the control system of the hybridization apparatus 10 is a control unit 40 for controlling the operation of the entire hybridization apparatus 10.
And the detection system of the hybridization device 10 is
A read head 17 for reading data recorded on the magnetic recording layer 5 of the biochemical analysis unit 1, and a cartridge 1.
A radiation sensor 30 for detecting the amount of the radiolabeled substance contained in the cleaning solution in 1 is provided.

As shown in FIG. 5, the drive system of the hybridization apparatus 10 comprises a pair of pulleys 16b, 16b.
c and the first motor 41 for driving the first endless belt 16a, and the pair of pulleys 20b, 20c.
To rotate the second endless belt 20a, a second motor 42 for driving the second endless belt 20a, a pair of pulleys 21b, 21c for rotating the third endless belt 21a, and a pair of A fifth motor 44 that rotates the pulleys 26b and 26c to drive the fourth endless belt 26a and a fifth motor 44 that rotates the pair of pulleys 28b and 28c to drive the fifth endless belt 28a.
Motor 45, the vibration table motor 46 that drives the vibration table 27, the pretreatment liquid injection pin 22, the hybridization solution injection pin 23, the probe solution injection pin 24, and the cleaning solution pin 25 selectively in the cartridge 11. The injection pin motor 47 that moves the solution pin head 26 along a pair of rails (not shown) so as to face the solution injection / extraction port 11c and the radiation sensor 30 are disposed in the cartridge 1 located at the solution extraction position.
A radiation sensor motor 48 which is moved between a detection position inside 1 and a retracted position retracted from inside the cartridge 11;
The solution extraction pin 31 is connected to the solution suction position in the cartridge 11 located at the solution extraction position and the cartridge 1
The pretreatment liquid is supplied to the pretreatment liquid injection pin 22 from the solution extraction pin motor 49 that is moved between the retreat position retracted from inside 1 and the pretreatment liquid tank (not shown) that stores the pretreatment liquid. A pretreatment liquid pump 50, a hybridization solution pump 51 that supplies the hybridization solution from a hybridization solution tank (not shown) that contains the hybridization solution to the hybridization solution injection pin 23, and a labeling substance. The probe solution pump 52 that supplies the probe solution to the probe solution injection pin 24 from the probe solution chip (not shown) that stores the probe solution containing the substance derived from the living body, and the cleaning solution tank that stores the cleaning solution (see FIG. (Not shown) supplies the cleaning solution to the cleaning solution pin 25 from the cleaning solution. A pump 53, solution extraction pin 31
A solution extracting pump 54 for extracting the prepared solution or the cleaning solution by adding the probe solution to the pretreatment liquid and the hybridization solution from the inside of the cartridge 11 via the cartridge 11, and the pretreatment liquid recovery tank for collecting the pretreatment liquid. (Not shown) A valve (not shown) for connecting the solution extracting pin 31 to each other, a hybridization solution collection tank (not shown) for collecting the prepared solution by adding the probe solution to the hybridization solution. A valve (not shown) communicating with the solution extracting pin 31 and a valve (not shown) communicating with the cleaning solution recovery tank (not shown) for collecting the cleaning solution and the solution extracting pin 31 are selectively opened and closed. A valve opening / closing mechanism 55 for
A loading mechanism 1 that opens and closes the lid 11b of the cartridge 11 to load the biochemical analysis unit 1 into the cartridge 11.
9, the lid 11b of the cartridge 11 is opened, and the biochemical analysis unit 1 is taken out from the cartridge 11; the biochemical analysis unit takeout mechanism 32 and the magnetic recording layer 5 of the biochemical analysis unit 1 are written with data. A magnetic recording head 18 is provided.

As shown in FIG. 5, the input system of the hybridization device 10 is equipped with a keyboard 60, and the display system of the hybridization device 10 is equipped with a display panel 61.

The hybridization apparatus 10 configured as described above is used in the following manner to bind a specific binding substance adsorbed to a large number of absorptive regions 4 formed on the substrate 2 of the biochemical analysis unit 1. Then, a substance derived from a living body labeled with a labeling substance is selectively hybridized.

First, a hybridization solution is prepared and accommodated in a hybridization solution tank (not shown), and a cleaning solution is prepared and accommodated in a cleaning solution (not shown).

On the other hand, a probe solution containing a substance of biological origin labeled with a labeling substance is prepared and housed in a probe solution chip (not shown).

In the case of selectively labeling a specific binding substance such as cDNA with a radioactive labeling substance, a probe solution containing a substance derived from a living body, which is a probe labeled with a radioactive labeling substance, is prepared, and a probe solution chip is prepared. Housed inside.

On the other hand, by using a labeling substance that causes chemiluminescence by contacting with a chemiluminescent substrate,
In the case of selectively labeling a specific binding substance such as, a probe solution containing a substance derived from a living organism, which is a probe labeled with a labeling substance that causes chemiluminescence by contacting with a chemiluminescent substrate, is prepared, It is housed in the probe solution chip.

Further, in the case of selectively labeling a specific binding substance such as cDNA with a fluorescent substance such as a fluorescent dye, a probe containing a substance derived from a living body which is a probe labeled with a fluorescent substance such as a fluorescent dye. A solution is prepared and housed in the probe solution chip.

[0147] A substance derived from a living body labeled with a radioactive labeling substance, a substance derived from a living body labeled with a labeling substance that causes chemiluminescence when brought into contact with a chemiluminescent substrate, and a living body labeled with a fluorescent substance such as a fluorescent dye Of the substances derived from the living body, a probe solution containing two or more living body-derived substances can be prepared and housed in the probe solution chip. In the present embodiment, the substance derived from the living body labeled with the radioactive labeling substance is used. A probe solution containing a substance of biological origin labeled with a fluorescent substance is prepared and housed in the probe solution chip.

For hybridization, c
A biochemical analysis unit 1 in which a specific binding substance such as DNA is adsorbed on a large number of absorptive regions 4 is set by the user on the first endless belt 16a of the cartridge loading unit 12, and is then placed on the keyboard 60. , Start signal is input. At the same time, the biologically-derived substance labeled with the radiolabeled substance is used for the biochemical analysis unit 1.
When hybridizing to the specific binding substance contained in a large number of the absorptive regions 4, the radiolabeled signal and the nuclide identification signal that identifies the nuclide of the radiolabeled substance are input to the keyboard 60 by the user. In the present embodiment, a probe solution containing a substance derived from a living body labeled with a radiolabeling substance is prepared and housed in a probe solution chip, so that a radiolabeling signal and a nuclide specifying signal for identifying a nuclide of the radiolabeling substance Is entered.

The start signal, radiolabel signal and nuclide identification signal input to the keyboard 60 are output to the control unit 40.

Upon receiving the start signal, the control unit 40 outputs a drive signal to the first motor 41,
By rotating the pair of pulleys 16b and 16c, the first endless belt 16 is driven clockwise in FIG.

When the magnetic recording layer 5 of the biochemical analysis unit 1 set on the first endless belt 16a reaches the position facing the read head 17, the control unit 40 drives the first motor 41. A stop signal is output to stop the first endless belt 16a, and the read head 17 reads the data recorded on the magnetic recording layer 5.

In this embodiment, the magnetic recording layer 5 has ID data unique to each biochemical analysis unit 1, data relating to the date and time at which hybridization was performed using the biochemical analysis unit 1, Data on the number of times the biochemical analysis unit 1 was used for hybridization, and when a radiolabeled substance was used as a labeling substance during hybridization, radiolabeled data indicating that a radiolabeled substance was used ,
Data such as radionuclides nuclides are recorded.

The data read by the read head 17 is output to the control unit 40, and the control unit 40, based on the data on the number of times used for hybridization, input from the read head 17, the biochemical analysis unit 1 However, when it is determined that the first motor 41 has been used for N times, a reverse rotation signal is output to the first motor 41, and
3 is rotated counterclockwise to return the biochemical analysis unit 1 to the user and display a message on the display panel 61 indicating that the biochemical analysis unit 1 should be replaced.

This is because when the biochemical analysis unit 1 is used for a predetermined number of times N or more, the specific binding substance adsorbed in the absorptive region 4 is peeled off, and the accuracy of analysis is remarkably reduced, resulting in reliability. This is because it is not possible to obtain accurate analysis results. N is set to 2, for example.

The biochemical analysis unit 1 sent back to the user is managed according to the data recorded in the magnetic recording layer 5 of the biochemical analysis unit 1, and is then discarded, as described later.

On the other hand, when it is judged that the number of times of use of the biochemical analysis unit 1 is less than N times based on the data on the number of times of use for hybridization inputted from the reading head 17, the control is performed. The unit 40 further outputs a drive signal to the first motor 41 to cause the biochemical analysis unit 1 to move to the magnetic recording layer 5.
Is moved to a position facing the magnetic recording head 18.

When the biochemical analysis unit 1 is moved to a position where the magnetic recording layer 5 faces the magnetic recording head 18,
The drive stop signal from the control unit 40 is the first
Output to the motor 41.

Then, the control unit 40 generates data regarding the date and time when the hybridization is carried out according to a built-in clock (not shown), and based on the inputted radiolabel signal and nuclide identification signal, Outputs a write signal to the magnetic recording head 18,
The number of times of use of the biochemical analysis unit 1 included in the data on the number of times of use for hybridization recorded in the magnetic recording layer 5 of the biochemical analysis unit 1 is increased by one, and the date and time of execution of hybridization are related. The data, the radiolabeling data, and the data related to the nuclides are recorded in the magnetic recording layer 5 of the biochemical analysis unit 1.
To write to. .

When the writing of data to the magnetic recording layer 5 is completed, the control unit 40 causes the first motor 4
1, the drive signal is output again, the pulleys 16b and 16c are rotated, and the biochemical analysis unit 1 is conveyed to the loading mechanism 19.

In the loading mechanism 19, the cartridge 11
However, the lid 11b is held open, and the biochemical analysis unit 1 is fed into the cartridge 11 by the first endless belt 16.

When the biochemical analysis unit 1 is fed into the cartridge 11, the control unit 40
Outputs a drive stop signal to the first motor 41,
While stopping the driving of the endless belt 16 of
A loading signal is output to the loading mechanism 19, and the cartridge 11
The lid 11b is closed.

Then, the control unit 40 outputs a drive signal to the second motor 42, and in FIG.
Turn the pulleys 20b and 20c clockwise to
Drive the endless belt 20a of the
3 to drive the third endless belt 21a by rotating the pulleys 21b and 21c clockwise in FIG.

As a result, the cartridge 11 containing the biochemical analysis unit 1 is transferred from the second endless belt 20a of the cartridge loading section 12 to the third endless belt 21a of the solution injection section 13.

When the cartridge 11 is delivered to the third endless belt 21a of the solution injecting section 13, the control unit 40 outputs a drive stop signal to the second motor 42, and the control unit 40 outputs the second endless belt 20a. When the drive is stopped and the cartridge 11 is moved to the solution injection position by the third endless belt 21a, the control unit 40 outputs a drive stop signal to the third motor 43 to stop the cartridge 11.

Next, the control unit 40 outputs a drive signal to the injection pin motor 47 to move the solution pin head 26 along the pair of rails (not shown) so that the pretreatment liquid injection pin 22 causes the solution of the cartridge 11 to flow. It is moved until it reaches a position facing the injection / extraction port 11c.

The pretreatment liquid injection pin 22 is used for the cartridge 1
When the control unit 40 is moved to a position facing the solution injection / withdrawal port 11c of No. 1, the control unit 40 outputs a drive signal to the pretreatment liquid pump 50 and the pretreatment liquid tank (not shown) The pretreatment liquid is supplied to the cartridge 11 through the injection pin 22 and the solution injection / extraction port 11c.
Let it inject.

After a lapse of a predetermined time, the control unit 40 outputs a drive stop signal to the pretreatment liquid pump 50 to stop the injection of the pretreatment liquid into the cartridge 11 and drive the third motor 45. A signal is output to drive the third endless belt 21a.

At the same time, the control unit 40 outputs a drive signal to the fourth motor 44, and in FIG.
Rotate the pulleys 26b and 26c clockwise to move the fourth pulley.
The endless belt 26a is driven.

As a result, the cartridge 11 accommodating the biochemical analysis unit 1 is transferred from the third endless belt 21a of the solution injection section 13 to the fourth endless belt 26a of the reaction section 14.

When the cartridge 11 is delivered to the fourth endless belt 26a of the reaction section 14, the control unit 40 outputs a drive stop signal to the third motor 43 to drive the third endless belt 21a. And the cartridge 11 is moved to the approximate center of the reaction section 14 by the fourth endless belt 26a,
The control unit 40 outputs a drive stop signal to the fourth motor 44 to stop the cartridge 11.

Next, the control unit 40 outputs a drive signal to the vibration table motor 46 to vibrate the vibration table 28.

As a result, vibration is applied to the cartridge 11, and all the absorptive regions 4 of the biochemical analysis unit 1 housed in the cartridge 11 are moistened by the pretreatment liquid.

When the predetermined time has elapsed, the control unit 40 outputs a drive stop signal to the vibration table motor 46 to stop the vibration of the vibration table 28, and the fourth
3 to drive the motor 44 to rotate the pulleys 26b and 26c clockwise in FIG. 3 to drive the fourth endless belt 26a and to output a drive signal to the fifth motor 45. In FIG. 3, the pulleys 28b and 28c are rotated clockwise to drive the fifth endless belt 28a.

As a result, the cartridge 11 has the reaction part 1
4 from the fourth endless belt 26a to the fifth endless belt 28 of the biochemical analysis unit takeout unit 15.
handed over to a.

When the cartridge 11 is transferred to the fifth endless belt 28a of the biochemical analysis unit take-out section 15, the control unit 40 outputs a drive stop signal to the fourth motor 44, and the fourth motor 44 is driven. When the driving of the endless belt 26a is stopped and the cartridge 11 is moved to the solution extracting position by the fifth endless belt 28a, the control unit 40 causes the fifth unit to move to the fifth position.
A drive stop signal is output to the motor 45 to stop the drive of the fifth endless belt 28a.

Next, the control unit 40 outputs a drive signal to the valve opening / closing mechanism 55 to connect the pretreatment liquid recovery tank (not shown) for recovering the pretreatment liquid to the solution extraction pin 31 (FIG. (Not shown) is opened, a drive signal is output to the solution extraction pin motor 49, the solution extraction pin 31 is moved to the solution suction position in the cartridge 11, and a drive signal is output to the solution extraction pump 54 to drive the cartridge. The pretreatment liquid in 11 is sucked.

In this way, when the pretreatment liquid in the cartridge 11 is sucked by the solution extraction pump 54 and collected in the pretreatment liquid recovery tank, the control unit 4
0 outputs a reverse drive signal to the fifth motor 45, and
In the above, by rotating the pulleys 28b and 28c counterclockwise to drive the fifth endless belt 28a, a reverse drive signal is output to the fourth motor 44,
In FIG. 3, the pulleys 26b and 26c are rotated counterclockwise.
Is rotated to drive the fourth endless belt 26a.

As a result, the cartridge 11 includes the fifth endless belt 28a of the biochemical analysis unit take-out section 15 to the fourth endless belt 26 of the reaction section 14.
handed over to a.

When the cartridge 11 is transferred to the fourth endless belt 26a of the reaction section 14, the control unit 40 outputs a drive stop signal to the fifth motor 45 to drive the fifth endless belt 28a. And the reverse drive signal is output to the third motor 43 to rotate the pulley 21b, counterclockwise in FIG.
21c is rotated to drive the third endless belt 21a.

As a result, the cartridge 11 has the reaction section 1
4 from the fourth endless belt 26a to the solution injection part 1
And the third endless belt 21a.

When the cartridge 11 is delivered to the third endless belt 21a of the solution injecting section 13, the control unit 40 outputs a drive stop signal to the fourth motor 44 to cause the fourth endless belt 26a to move. When the drive is stopped and the cartridge 11 is moved to the solution injection position by the third endless belt 21a, the control unit 40 outputs a drive stop signal to the third motor 43, and the third endless belt 21a. Stop driving.

Then, the control unit 40 outputs a drive signal to the injection pin motor 47, and the hybridization solution injection pin 23 is moved to the cartridge 11 along the solution pin head 26 and a pair of rails (not shown).
The solution is moved until it reaches a position facing the solution injection / extraction port 11c.

In this way, when the hybridization solution injection pin 23 is moved to the position facing the solution injection / extraction port 11c of the cartridge 11, the control unit 40 causes the hybridization solution pump 51 to move.
A driving signal is output to the cartridge 11 from the hybridization solution tank (not shown) via the hybridization solution injection pin 23 and the solution injection / extraction port 11c.
Let it inject.

After a predetermined time has passed, the control unit 40 turns on the hybridization solution pump 51.
A drive stop signal is output to stop the injection of the hybridization solution, and a drive signal is output to the third motor 43 to rotate the pulleys 21b and 21c clockwise in FIG. The endless belt 21a is driven.

At the same time, the control unit 40 outputs a drive signal to the fourth motor 44, and in FIG.
Rotate the pulleys 26b and 26c clockwise to move the fourth pulley.
The endless belt 26a is driven.

As a result, the cartridge 11 accommodating the biochemical analysis unit 1 is transferred from the third endless belt 21a of the solution injection section 13 to the fourth endless belt 26a of the reaction section 14.

When the cartridge 11 is delivered to the fourth endless belt 26a of the reaction section 14, the control unit 40 outputs a drive stop signal to the third motor 43 to drive the third endless belt 21a. And the cartridge 11 is moved to the approximate center of the reaction section 14 by the fourth endless belt 26a,
The control unit 40 outputs a drive stop signal to the fourth motor 44 to stop the cartridge 11.

Then, the control unit 40 outputs a drive signal to the vibration table motor 46 to vibrate the vibration table 28.

As a result, the cartridge 11 is vibrated, and the hybridization solution is brought into uniform contact with all the absorptive regions 4 of the biochemical analysis unit 1 housed in the cartridge 11, and pre-hybridization is performed. To be done.

When the predetermined time has passed, the control unit 40 outputs a drive stop signal to the vibration table motor 46 to stop the vibration of the vibration table 28, and the fourth
The reverse drive signal is output to the motor 44 of FIG.
Rotate the pulleys 26b and 26c counterclockwise,
While driving the fourth endless belt 26a,
A reverse drive signal is output to the third motor 43 to rotate the pulleys 21b and 21c counterclockwise in FIG. 3 to drive the third endless belt 21a.

As a result, the cartridge 11 has the reaction part 1
4 from the fourth endless belt 26a to the solution injection part 1
And the third endless belt 21a.

When the cartridge 11 is delivered to the third endless belt 21a of the solution injecting section 13, the control unit 40 outputs a drive stop signal to the fourth motor 44 to cause the fourth endless belt 26a to move. When the drive is stopped and the cartridge 11 is moved to the solution injection position by the third endless belt 21a, the control unit 40 outputs a drive stop signal to the third motor 43, and the third endless belt 21a. Stop driving.

Next, the control unit 40 outputs a drive signal to the injection pin motor 47, and the probe solution injection pin 24 causes the solution injection head 24 and the pair of rails (not shown) to inject the solution in the cartridge 11. It is moved until it reaches a position facing the extraction port 11c.

Thus, when the probe solution injection pin 24 is moved to the position facing the solution injection / extraction port 11c of the cartridge 11, the control unit 40
A drive signal is output to the probe solution pump 52 to inject the probe solution into the cartridge 11 from the probe solution chip (not shown) via the probe solution injection pin 24 and the solution injection / extraction port 11c.

As a result, the probe solution containing the substance of biological origin labeled with the labeling substance is added to the hybridization solution contained in the cartridge 11.

When a predetermined time has elapsed, the control unit 40 outputs a drive stop signal to the probe solution pump 52 to stop the injection of the probe solution and outputs a drive signal to the third motor 43, In FIG. 3, the pulleys 21b and 21c are rotated clockwise to drive the third endless belt 21a.

At the same time, the control unit 40 outputs a drive signal to the fourth motor 44, and in FIG.
Rotate the pulleys 26b and 26c clockwise to move the fourth pulley.
The endless belt 26a is driven.

As a result, the cartridge 11 accommodating the biochemical analysis unit 1 is transferred from the third endless belt 21a of the solution injection section 13 to the fourth endless belt 26a of the reaction section 14.

When the cartridge 11 is delivered to the fourth endless belt 26a of the reaction section 14, the control unit 40 outputs a drive stop signal to the third motor 43 to drive the third endless belt 21a. And the cartridge 11 is moved to the approximate center of the reaction section 14 by the fourth endless belt 26a,
The control unit 40 outputs a drive stop signal to the fourth motor 44 to stop the cartridge 11.

Then, the control unit 40 outputs a drive signal to the vibration table motor 46 to vibrate the vibration table 28.

As a result, the cartridge 11 is vibrated, and the probe solution containing the substance of biological origin labeled with the labeling substance is present in all the absorptive regions 4 of the biochemical analysis unit 1 accommodated in the cartridge 11. The hybridization solution to which is added is uniformly contacted, and the substance derived from the living body labeled with the radiolabeled substance and the substance derived from the living body labeled with the fluorescent substance are adsorbed on a large number of adsorbent regions 4. The specific binding substance that hybridizes selectively with the binding substance and is adsorbed on the large number of adsorptive regions 4 is selectively labeled with the radioactive labeling substance and the fluorescent substance.

When a predetermined time has elapsed, the control unit 40 outputs a drive stop signal to the vibration table motor 46 to stop the vibration of the vibration table 28, and the fourth
3 to drive the motor 44 to rotate the pulleys 26b and 26c clockwise in FIG. 3 to drive the fourth endless belt 26a and to output a drive signal to the fifth motor 45. In FIG. 3, the pulleys 28b and 28c are rotated clockwise to drive the fifth endless belt 28a.

As a result, the cartridge 11 has the reaction section 1
4 from the fourth endless belt 26a to the fifth endless belt 28 of the biochemical analysis unit takeout unit 15.
handed over to a.

When the cartridge 11 is delivered to the fifth endless belt 28a of the biochemical analysis unit take-out section 15, the control unit 40 outputs a drive stop signal to the fourth motor 44, and the fourth motor 44 is driven. When the driving of the endless belt 26a is stopped and the cartridge 11 is moved to the solution extracting position by the fifth endless belt 28a, the control unit 40 causes the fifth unit to move to the fifth position.
A drive stop signal is output to the motor 45 to stop the drive of the fifth endless belt 28a.

Next, the control unit 40 outputs a drive signal to the valve opening / closing mechanism 55, the probe solution is added to the hybridization solution, and the hybridization solution recovery tank for recovering the prepared solution and the solution extraction pin 31. A valve (not shown) communicating with and is opened, a drive signal is output to the solution extraction pin motor 49, the solution extraction pin 31 is moved to the solution suction position in the cartridge 11, and the solution extraction pump 54 is driven. A signal is output, the probe solution is added to the hybridization solution in the cartridge 11, and the prepared solution is sucked.

In this way, when the probe solution is added to the hybridization solution in the cartridge 11 and the prepared solution is sucked by the solution withdrawing pump 54 and collected in the hybridization solution collecting tank, the control unit 40 Fifth motor 45
The reverse drive signal is output to, and the pulleys 28b and 28c are rotated counterclockwise in FIG. 3 to drive the fifth endless belt 28a, and the reverse drive signal is output to the fourth motor 44. Then, in FIG. 3, the pulleys 26b and 26c are rotated counterclockwise to drive the fourth endless belt 26a.

As a result, the cartridge 11 is changed from the fifth endless belt 28a of the biochemical analysis unit take-out section 15 to the fourth endless belt 26 of the reaction section 14.
handed over to a.

When the cartridge 11 is delivered to the fourth endless belt 26a of the reaction section 14, the control unit 40 outputs a drive stop signal to the fifth motor 45 to drive the fifth endless belt 28a. And the reverse drive signal is output to the third motor 43 to rotate the pulley 21b, counterclockwise in FIG.
21c is rotated to drive the third endless belt 21a.

As a result, the cartridge 11 has the reaction part 1
4 from the fourth endless belt 26a to the solution injection part 1
And the third endless belt 21a.

When the cartridge 11 is delivered to the third endless belt 21a of the solution injecting section 13, the control unit 40 outputs a drive stop signal to the fourth motor 44 to cause the fourth endless belt 26a to move. When the drive is stopped and the cartridge 11 is moved to the solution injection position by the third endless belt 21a, the control unit 40 outputs a drive stop signal to the third motor 43, and the third endless belt 21a. Stop driving.

Next, the control unit 40 outputs a drive signal to the injection pin motor 47, and the cleaning solution injection pin 25 causes the solution injection head 25 and the pair of rails (not shown) to inject the solution in the cartridge 11. It is moved until it reaches a position facing the extraction port 11c.

In this way, when the hybridization solution injection pin 23 is moved to the position facing the solution injection / withdrawal port 11c of the cartridge 11, the control unit 40 outputs a drive signal to the cleaning solution pump 53 to cause the cleaning solution to flow. A cleaning solution is injected into the cartridge 11 from a tank (not shown) via the cleaning solution injection pin 25 and the solution injection / extraction port 11c.

When the predetermined time has passed, the control unit 40 outputs a drive stop signal to the cleaning solution pump 53 to stop the injection of the cleaning solution and also outputs a drive signal to the third motor 43. In FIG. 3, the pulleys 21b and 21c are rotated clockwise to drive the third endless belt 21a.

At the same time, the control unit 40 outputs a drive signal to the fourth motor 44, and in FIG.
Rotate the pulleys 26b and 26c clockwise to move the fourth pulley.
The endless belt 26a is driven.

As a result, the cartridge 11 accommodating the biochemical analysis unit 1 is transferred from the third endless belt 21a of the solution injection section 13 to the fourth endless belt 26a of the reaction section 14.

When the cartridge 11 is delivered to the fourth endless belt 26a of the reaction section 14, the control unit 40 outputs a drive stop signal to the third motor 43 to drive the third endless belt 21a. And the cartridge 11 is moved to the approximate center of the reaction section 14 by the fourth endless belt 26a,
The control unit 40 outputs a drive stop signal to the fourth motor 44 to stop the cartridge 11.

Next, the control unit 40 outputs a drive signal to the vibration table motor 46 to vibrate the vibration table 28.

As a result, the cartridge 11 is vibrated, and the cleaning solution is uniformly contacted with all the absorptive regions 4 of the biochemical analysis unit 1 housed in the cartridge 11, and the absorptive regions 4 are washed. To be done.

When the predetermined time has elapsed, the control unit 40 outputs a drive stop signal to the vibration table motor 46 to stop the vibration of the vibration table 28, and the fourth
3 to drive the motor 44 to rotate the pulleys 26b and 26c clockwise in FIG. 3 to drive the fourth endless belt 26a and to output a drive signal to the fifth motor 45. In FIG. 3, the pulleys 28b and 28c are rotated clockwise to drive the fifth endless belt 28a.

As a result, the cartridge 11 has the reaction part 1
4 from the fourth endless belt 26a to the fifth endless belt 28 of the biochemical analysis unit takeout unit 15.
handed over to a.

When the cartridge 11 is delivered to the fifth endless belt 28a of the biochemical analysis unit take-out section 15, the control unit 40 outputs a drive stop signal to the fourth motor 44, and the fourth motor 44 is driven. When the driving of the endless belt 26a is stopped and the cartridge 11 is moved to the solution extracting position by the fifth endless belt 28a, the control unit 40 causes the fifth unit to move to the fifth position.
A drive stop signal is output to the motor 45 to stop the drive of the fifth endless belt 28a.

In the present embodiment, since the radiation indicator signal is input from the keyboard 60, the control unit 40 then outputs a drive signal to the radiation sensor motor 48 to move the radiation sensor 30 into the cartridge 11. And a drive signal is output to the valve opening / closing mechanism 55 to open a valve (not shown) which connects the cleaning solution recovery tank for recovering the cleaning solution and the solution extraction pin 31 to open the solution. The drive signal is output to the pin motor 49, and the solution extraction pin 31
Is moved to the solution suction position in the cartridge 11.

In this way, the concentration of the radiolabeled substance in the cleaning solution contained in the cartridge 11 is detected by the radiation sensor 30, and the detection signal is output to the control unit 40.

Further, the control unit 40 outputs a drive signal to the solution extraction pump 54 to suck the cleaning solution in the cartridge 11 and recover the cleaning solution in a cleaning solution recovery tank (not shown).

When a predetermined time has passed, the control unit 40 outputs a drive stop signal to the solution withdrawing pump 54 to stop suction of the cleaning solution in the cartridge 11 and outputs a drive signal to the solution withdrawing pin motor 49. Then, the solution extracting pin 31 is retracted to the retracted position retracted from the cartridge 11, and a drive signal is output to the radiation sensor motor 48 to cause the radiation sensor 30 to move.
Is retracted from the cartridge 11 to the retracted position.

On the other hand, the control unit 40 stores the concentration of the radioactive labeling substance in the washing solution in a memory (not shown) based on the detection signal input from the radiation sensor 30.
Compare with the reference concentration of radiolabeled substance stored in.

As a result, when the concentration of the radioactive labeling substance in the washing solution exceeds the standard concentration of the radioactive labeling substance,
Since the cleaning of the adsorptive region 4 is not sufficient and it is recognized that the cleaning solution needs to be injected into the cartridge 11 to continue the cleaning operation, the control unit 40 controls the cleaning solution in the cartridge 11 to be a pump for extracting the solution. When it is sucked by 54 and collected in the cleaning solution collection tank, a reverse drive signal is output to the fifth motor 45 to rotate the pulleys 28b and 28c counterclockwise in FIG. Endless belt 28a is driven, and a reverse drive signal is output to the fourth motor 44 to rotate the pulleys 26b and 26c counterclockwise in FIG. 3 to drive the fourth endless belt 26a. .

As a result, the cartridge 11 is changed from the fifth endless belt 28a of the biochemical analysis unit take-out section 15 to the fourth endless belt 26 of the reaction section 14.
handed over to a.

When the cartridge 11 is delivered to the fourth endless belt 26a of the reaction section 14, the control unit 40 outputs a drive stop signal to the fifth motor 45 to drive the fifth endless belt 28a. And the reverse drive signal is output to the third motor 43 to rotate the pulley 21b, counterclockwise in FIG.
21c is rotated to drive the third endless belt 21a.

As a result, the cartridge 11 has the reaction unit 1
4 from the fourth endless belt 26a to the solution injection part 1
And the third endless belt 21a.

When the cartridge 11 is delivered to the third endless belt 21a of the solution injecting section 13, the control unit 40 outputs a drive stop signal to the fourth motor 44 to cause the fourth endless belt 26a to move. When the drive is stopped and the cartridge 11 is moved to the solution injection position by the third endless belt 21a, the control unit 40 outputs a drive stop signal to the third motor 43, and the third endless belt 21a. Stop driving.

When the cartridge 11 is returned to the solution injection position in this way, the control unit 40 again outputs a drive signal to the cleaning solution pump 53, and the cleaning solution injection pin is supplied from the cleaning solution tank (not shown). 25 and the cleaning solution via the solution inlet / outlet port 11c.
It is injected into the cartridge 11.

When a predetermined time has passed, the control unit 40 outputs a drive stop signal to the cleaning solution pump 53 to stop the injection of the cleaning solution and also outputs a drive signal to the third motor 43. In FIG. 3, the pulleys 21b and 21c are rotated clockwise to drive the third endless belt 21a.

At the same time, the control unit 40 outputs a drive signal to the fourth motor 44, and in FIG.
Rotate the pulleys 26b and 26c clockwise to move the fourth pulley.
The endless belt 26a is driven.

As a result, the cartridge 11 accommodating the biochemical analysis unit 1 is transferred from the third endless belt 21a of the solution injection section 13 to the fourth endless belt 26a of the reaction section 14.

When the cartridge 11 is transferred to the fourth endless belt 26a of the reaction section 14, the control unit 40 outputs a drive stop signal to the third motor 43 to drive the third endless belt 21a. And the cartridge 11 is moved to the approximate center of the reaction section 14 by the fourth endless belt 26a,
The control unit 40 outputs a drive stop signal to the fourth motor 44 to stop the cartridge 11.

Next, the control unit 40 outputs a drive signal to the vibration table motor 46 to vibrate the vibration table 28.

As a result, the cartridge 11 is vibrated, and the cleaning solution is uniformly contacted with all the absorptive regions 4 of the biochemical analysis unit 1 accommodated in the cartridge 11, and the absorptive regions 4 are washed. To be done.

When the predetermined time has passed, the control unit 40 outputs a drive stop signal to the vibration table motor 46 to stop the vibration of the vibration table 28, and the fourth
3 to drive the motor 44 to rotate the pulleys 26b and 26c clockwise in FIG. 3 to drive the fourth endless belt 26a and to output a drive signal to the fifth motor 45. In FIG. 3, the pulleys 28b and 28c are rotated clockwise to drive the fifth endless belt 28a.

As a result, the cartridge 11 has the reaction part 1
4 from the fourth endless belt 26a to the fifth endless belt 28 of the biochemical analysis unit takeout unit 15.
handed over to a.

When the cartridge 11 is transferred to the fifth endless belt 28a of the biochemical analysis unit take-out section 15, the control unit 40 outputs a drive stop signal to the fourth motor 44, and the fourth motor 44 is driven. When the driving of the endless belt 26a is stopped and the cartridge 11 is moved to the solution extracting position by the fifth endless belt 28a, the control unit 40 causes the fifth unit to move to the fifth position.
A drive stop signal is output to the motor 45 to stop the drive of the fifth endless belt 28a.

Next, the control unit 40 outputs a drive signal to the radiation sensor motor 48 to move the radiation sensor 30 to the detection position in the cartridge 11, and outputs a drive signal to the valve opening / closing mechanism 55. A valve (not shown) that connects the cleaning solution recovery tank for recovering the cleaning solution and the solution extraction pin 31 is opened, a drive signal is output to the solution extraction pin motor 49, and the solution extraction pin 31 is inserted into the cartridge 11. Move to the solution suction position.

In this way, the concentration of the radioactive labeling substance in the cleaning solution housed in the cartridge 11 is detected by the radiation sensor 30, and the detection signal is output to the control unit 40.

Further, the control unit 40 outputs a drive signal to the solution extracting pump 54 to suck the cleaning solution in the cartridge 11 and collect the cleaning solution in the cleaning solution recovery tank (not shown).

After a lapse of a predetermined time, the control unit 40 outputs a drive stop signal to the solution withdrawing pump 54 to stop the suction of the cleaning solution in the cartridge 11 and outputs a drive signal to the solution withdrawing pin motor 49. Then, the solution extracting pin 31 is retracted to the retracted position retracted from the cartridge 11, and a drive signal is output to the radiation sensor motor 48 to cause the radiation sensor 30 to move.
Is retracted from the cartridge 11 to the retracted position.

On the other hand, the control unit 40 stores the concentration of the radioactive labeling substance in the cleaning solution in a memory (not shown) based on the detection signal input from the radiation sensor 30.
Compare with the reference concentration of radiolabeled substance stored in.

As a result, when the concentration of the radioactive labeling substance in the washing solution exceeds the standard concentration of the radioactive labeling substance,
Since it is recognized that the cleaning of the adsorptive region 4 is still insufficient and it is necessary to further inject the cleaning solution into the cartridge 11 to continue the cleaning operation, the control unit 40 causes the cleaning solution in the cartridge 11 to At the time when it is sucked by the solution withdrawing pump 54 and collected in the cleaning solution recovery tank, a reverse drive signal is output to the fifth motor 45, and the pulley 28 is rotated counterclockwise in FIG.
Rotate b and 28c to move the fifth endless belt 28
In addition to driving a, the reverse drive signal is output to the fourth motor 44, and in FIG. 3, the pulleys 26b and 26c are rotated counterclockwise to drive the fourth endless belt 26a to drive the cartridge 11 To the fifth endless belt 28 of the biochemical analysis unit take-out section 15.
It is passed from a to the fourth endless belt 26a of the reaction section 14.

When the cartridge 11 is delivered to the fourth endless belt 26a of the reaction section 14, the control unit 40 outputs a drive stop signal to the fifth motor 45 to drive the fifth endless belt 28a. And the reverse drive signal is output to the third motor 43 to rotate the pulley 21b, counterclockwise in FIG.
21c is rotated to drive the third endless belt 21a.

As a result, the cartridge 11 has the reaction part 1
4 from the fourth endless belt 26a to the solution injection part 1
And the third endless belt 21a.

When the cartridge 11 is delivered to the third endless belt 21a of the solution injecting section 13, the control unit 40 outputs a drive stop signal to the fourth motor 44 to cause the fourth endless belt 26a to move. When the drive is stopped and the cartridge 11 is moved to the solution injection position by the third endless belt 21a, the control unit 40 outputs a drive stop signal to the third motor 43, and the third endless belt 21a. Stop driving.

In this way, when the cartridge 11 is returned to the solution injection position, the control unit 40 outputs the drive signal to the cleaning solution pump 53 again, and the cleaning solution injection pin is supplied from the cleaning solution tank (not shown). 25 and the cleaning solution via the solution inlet / outlet port 11c.
It is injected into the cartridge 11.

When the predetermined time has passed, the control unit 40 outputs a drive stop signal to the cleaning solution pump 53 to stop the injection of the cleaning solution and also outputs a drive signal to the third motor 43. In FIG. 3, the pulleys 21b and 21c are rotated clockwise to drive the third endless belt 21a.

At the same time, the control unit 40 outputs a drive signal to the fourth motor 44, and in FIG.
Rotate the pulleys 26b and 26c clockwise to move the fourth pulley.
The endless belt 26a is driven.

As a result, the cartridge 11 accommodating the biochemical analysis unit 1 is transferred from the third endless belt 21a of the solution injection section 13 to the fourth endless belt 26a of the reaction section 14.

When the cartridge 11 is delivered to the fourth endless belt 26a of the reaction section 14, the control unit 40 outputs a drive stop signal to the third motor 43 to drive the third endless belt 21a. And the cartridge 11 is moved to the approximate center of the reaction section 14 by the fourth endless belt 26a,
The control unit 40 outputs a drive stop signal to the fourth motor 44 to stop the cartridge 11.

Next, the control unit 40 outputs a drive signal to the vibration table motor 46 to vibrate the vibration table 28.

As a result, the cartridge 11 is vibrated, and the cleaning solution is brought into uniform contact with all the absorptive regions 4 of the biochemical analysis unit 1 accommodated in the cartridge 11, and the absorptive regions 4 are washed. To be done.

When the predetermined time has passed, the control unit 40 outputs a drive stop signal to the vibration table motor 46 to stop the vibration of the vibration table 28, and the fourth
3 to drive the motor 44 to rotate the pulleys 26b and 26c clockwise in FIG. 3 to drive the fourth endless belt 26a and to output a drive signal to the fifth motor 45. In FIG. 3, the pulleys 28b and 28c are rotated clockwise to drive the fifth endless belt 28a.

As a result, the cartridge 11 has the reaction part 1
4 from the fourth endless belt 26a to the fifth endless belt 28 of the biochemical analysis unit takeout unit 15.
handed over to a.

When the cartridge 11 is delivered to the fifth endless belt 28a of the biochemical analysis unit take-out section 15, the control unit 40 outputs a drive stop signal to the fourth motor 44, and the fourth motor 44 is driven. When the driving of the endless belt 26a is stopped and the cartridge 11 is moved to the solution extracting position by the fifth endless belt 28a, the control unit 40 causes the fifth unit to move to the fifth position.
A drive stop signal is output to the motor 45 to stop the drive of the fifth endless belt 28a.

Next, the control unit 40 outputs a drive signal to the radiation sensor motor 48 to move the radiation sensor 30 to the detection position in the cartridge 11, and outputs a drive signal to the valve opening / closing mechanism 55, A valve (not shown) that connects the cleaning solution recovery tank for recovering the cleaning solution and the solution extraction pin 31 is opened, a drive signal is output to the solution extraction pin motor 49, and the solution extraction pin 31 is inserted into the cartridge 11. Move to the solution suction position.

In this way, the concentration of the radiolabeled substance in the cleaning solution contained in the cartridge 11 is detected by the radiation sensor 30, and the detection signal is output to the control unit 40.

Further, the control unit 40 outputs a drive signal to the solution extracting pump 54 to suck the cleaning solution in the cartridge 11 and recover the cleaning solution in a cleaning solution recovery tank (not shown).

When a predetermined time has passed, the control unit 40 outputs a drive stop signal to the solution withdrawing pump 54 to stop suction of the cleaning solution in the cartridge 11 and outputs a drive signal to the solution withdrawing pin motor 49. Then, the solution extracting pin 31 is retracted to the retracted position retracted from the cartridge 11, and a drive signal is output to the radiation sensor motor 48 to cause the radiation sensor 30 to move.
Is retracted from the cartridge 11 to the retracted position.

On the other hand, based on the detection signal input from the radiation sensor 30 by the control unit 40, the concentration of the radioactive labeling substance in the cleaning solution and the radioactive labeling substance reference stored in the memory (not shown) The concentration is compared.

Thus, until the concentration of the radiolabeled substance in the washing solution falls below the radiolabeled substance standard concentration,
When the washing with the washing solution is repeated and the concentration of the radiolabeling substance in the washing solution drops below the radiolabeling substance reference concentration, the control unit 40 determines that the washing is completed and drives the fifth motor 45. A signal is output, and in FIG. 3, the pulleys 28b and 28c are rotated clockwise to drive the fifth endless belt 28a.

As a result, the fifth endless belt 28a
Thus, the cartridge 11 is sent to the biochemical analysis unit removal mechanism 32.

In this embodiment, since the substance of biological origin contained in the probe solution is labeled with the radioactive labeling substance, the radiation sensor 30 detects the concentration of the radioactive labeling substance in the washing solution. Then, the washing solution is repeatedly washed until the concentration of the radiolabeled substance in the wash solution falls below the radiolabeled substance standard concentration, but the substance of biological origin contained in the probe solution is changed by the radiolabeled substance. When not labeled, the control unit 40 is configured to complete the wash operation when the wash solution has been injected a predetermined number of times to determine that a wash has been performed.

When the cartridge 11 is sent to the biochemical analysis unit removal mechanism 32, the control unit 40 outputs a drive stop signal to the fifth motor 45 to stop the drive of the fifth endless belt 28a. ,
A drive signal is output to the biochemical analysis unit extraction mechanism 32.

Biochemical analysis unit removal mechanism 32
When the drive signal is received from the control unit 40, opens the lid 11b of the cartridge 11 and takes out the biochemical analysis unit 1 housed in the cartridge 11.

In this way, the radiation data of the radioactive labeling substance which is the labeling substance and the fluorescence data of the fluorescent substance such as the fluorescent dye are recorded in the many absorptive regions 4 of the biochemical analysis unit 1. The fluorescence data recorded in the absorptive region 4 is read by a scanner described later, and biochemical analysis data is generated.

On the other hand, the radiation data of radiolabeled substance is
The radiation data transferred to the stimulable phosphor sheet and transferred to the stimulable phosphor sheet is read by a scanner described later to generate biochemical analysis data.

FIG. 6 is a schematic perspective view of the stimulable phosphor sheet.

As shown in FIG. 6, the stimulable phosphor sheet 70 according to this embodiment has a large number of substantially circular through holes 7.
3 includes a nickel-made support 71 that is regularly formed, and a stimulable phosphor is embedded in a large number of through holes 73 formed in the support 71 to form a large number of stimulable phosphor layers. The area 72 is formed in a dot shape.

The large number of through holes 73 are formed in the support 71 in the same pattern as the large number of absorptive regions 4 formed on the substrate 2 of the biochemical analysis unit 1, and each stimulable phosphor layer region. 72 is formed so as to have the same size as the absorptive region 4 formed on the substrate 2 of the biochemical analysis unit 1.

Therefore, although not shown exactly in FIG. 6, a substantially circular stimulable phosphor layer region 72 having a size of about 0.01 mm 2 of about 10000 is about 5.
The support 71 of the stimulable phosphor sheet 70 has a density of 000 pieces / square centimeter and the same regular pattern as the many absorptive regions 4 formed on the substrate 2 of the biochemical analysis unit 1, It is formed in a dot shape.

In addition, in this embodiment, the support 71
Surface and stimulable phosphor layer region 7 formed in a dot shape
The support 71 is placed so that the surface of
The stimulable phosphor is embedded in the through hole 73 formed in the above to form the stimulable phosphor sheet 70.

FIG. 7 shows a large number of dot-shaped stimulants formed on the stimulable phosphor sheet 70 by the radioactive labeling substance contained in the large number of absorptive regions 4 formed in the biochemical analysis unit 1. FIG. 6 is a schematic cross-sectional view showing a method of exposing the phosphor layer region 72.

At the time of exposure, the stimulable phosphor sheet 70 is superposed on the surface of the biochemical analysis unit 1 to form the absorptive region 4 formed in the biochemical analysis unit 1.
The dot-shaped stimulable phosphor layer region 72 formed on the stimulable phosphor sheet 70 by the radioactive labeling substance contained in
However, in the present embodiment, since the biochemical analysis unit 1 is formed by filling nylon 6 in a large number of through holes 3 formed in the substrate 2 made of aluminum, Even when subjected to a treatment with a liquid such as hybridization, it hardly expands or contracts. Therefore, each of the absorptive regions 4 formed in the biochemical analysis unit 1 corresponds to the accumulation phosphor sheet 70. The stimulable phosphor sheet 70 is superposed on the biochemical analysis unit 1 so as to exactly face the dot-shaped stimulable phosphor layer region 72, and the dot-shaped stimulable phosphor layer region 72 is formed. It becomes possible to expose.

In this way, each of the absorptive regions 4 formed in the biochemical analysis unit 1 over a predetermined period of time has a corresponding dot-shaped stimulable phosphor layer region formed in the stimulable phosphor sheet 70. By stacking the biochemical analysis unit 1 and the stimulable phosphor sheet 70 so as to face 72, the radioactive label substance contained in the adsorptive region 4 formed on the stimulable phosphor sheet 70. A large number of dot-shaped stimulable phosphor layer regions 72 are exposed.

At this time, an electron beam (β-ray) is emitted from the radiolabeled substance adsorbed in the absorptive region 4, but the absorptive region 4 of the biochemical analysis unit 1 has a property of attenuating radiation. Since the substrate 2 made of aluminum is formed in a dot shape with being separated from each other, the electron beam (β-ray) emitted from each absorptive region 4 is
The photostimulable phosphor layer scattered in the substrate 2 of the biochemical analysis unit 1 and mixed with the electron beam (β-ray) emitted from the adsorbing regions 4 adjacent to each other and facing the adsorbing regions 4 adjacent to each other. A nickel support that can effectively prevent the light from entering the region 72, and that the dot-shaped stimulable phosphor layer region 72 of the stimulable phosphor sheet 70 has a property of attenuating radiation. Many through holes 7 formed in 71
3 is formed by embedding a stimulable phosphor in the inside of 3, and the electron beam (β-ray) emitted from each absorptive region 4 is
It is possible to effectively prevent scattering in the support 71 of the stimulable phosphor sheet 70 and incidence on the stimulable phosphor layer region 72 adjacent to the opposing stimulable phosphor layer region 72. Therefore, the electron beam (β-ray) emitted from the radiolabel substance contained in the absorptive region 4 is selectively incident on the stimulable phosphor layer region 72 facing the absorptive region 4. The electron beam (β-ray) emitted from the radio-labeled substance contained in the adsorptive region 4 can be stimulable fluorescence to be exposed by the electron beam emitted from the adjacent adsorptive region 4. It is possible to reliably prevent the photostimulable phosphor from being exposed to light by entering the body layer region 72.

Thus, a large number of stimulable phosphor layer regions 72 formed on the support 71 of the stimulable phosphor sheet 70 are
Radiation data of radiolabeled substances are recorded.

In FIG. 8, the radiation data recorded on the stimulable phosphor sheet 70 is read to generate biochemical analysis data, and at the same time the fluorescence data recorded on the biochemical analysis unit 1 is read to obtain the raw data. FIG. 9 is a schematic perspective view of a scanner that generates data for chemical analysis, and FIG. 9 is a schematic perspective view showing details near the photomultiplier of the scanner shown in FIG. 8.

The scanner according to this embodiment is provided with a large number of radiochemical data and biochemical analysis unit 1 of the radiolabeled substance recorded in a large number of stimulable phosphor layer regions 72 formed on the stimulable phosphor sheet 70. The fluorescent data such as the fluorescent dye recorded in the absorptive region 4 is read.

As shown in FIG. 8, the scanner according to the present embodiment comprises a first laser excitation light source 81 which emits a laser beam 84 having a wavelength of 640 nm and a second laser excitation light source 84 which emits a laser beam 84 having a wavelength of 532 nm. Excitation light source 82 and 47
It is provided with a third laser excitation light source 83 which emits a laser beam 84 having a wavelength of 3 nm.

In the present embodiment, the first laser pumping light source 81 is composed of a semiconductor laser light source, and the second laser pumping light source 82 and the third laser pumping light source 83.
Is composed of a second harmonic generation element.

The laser light 84 generated by the first laser excitation light source 81 is collimated by the collimator lens 85 and then reflected by the mirror 86. First
In the optical path of the laser light 84 emitted from the laser excitation light source 81 and reflected by the mirror 86, a first dichroic mirror 87 that transmits the laser light 4 of 640 nm and reflects light of a wavelength of 532 nm and 532 nm or more A second dichroic mirror 88 that transmits light of a wavelength and reflects light of a wavelength of 473 nm is provided.
Laser light 84 generated by the laser excitation light source 81
Passes through the first dichroic mirror 87 and the second dichroic mirror 88 and enters the mirror 89.

On the other hand, the laser light 84 generated from the second laser excitation light source 82 is passed by the collimator lens 90.
After being made into parallel light, it is reflected by the first dichroic mirror 87, its direction is changed by 90 degrees, and
The light passes through the dichroic mirror 88 and enters the mirror 89.

Further, the laser light 84 generated from the third laser excitation light source 83 is collimated by the collimator lens 91, and then the second dichroic mirror 8 is formed.
After being reflected by 8 and changing its direction by 90 degrees,
It is incident on the mirror 89.

The laser beam 84 incident on the mirror 89 is reflected by the mirror 89, and further incident on the mirror 92 and reflected.

Laser light 8 reflected by mirror 92
A perforated mirror 94 formed by a concave mirror having a hole 93 formed in the central portion is arranged in the optical path of No. 4, and the laser light 84 reflected by the mirror 92 passes through the hole 93 of the perforated mirror 94. It passes through and enters the concave mirror 98.

Laser light 84 incident on the concave mirror 98
Is reflected by the concave mirror 98, and the optical head 9
It is incident on 5.

The optical head 95 is provided with a mirror 96 and an aspherical lens 97. The laser light 84 incident on the optical head 95 is reflected by the mirror 96, and the glass plate of the stage 100 is reflected by the aspherical lens 97. 101
It is incident on the stimulable phosphor sheet 70 placed on the top or the biochemical analysis unit 1.

The laser light 84 is applied to the stimulable phosphor sheet 70.
Is incident, the stimulable phosphor layer region 72 formed on the support 71 of the stimulable phosphor sheet 70 is excited, stimulable light 105 is emitted, and the biochemical analysis unit 1 is
When the laser light 84 enters, the fluorescent substance such as the fluorescent dye contained in the absorptive region 4 is excited, and the fluorescence 105 is emitted.

Photostimulable light 105 emitted from the stimulable phosphor layer region 72 of the stimulable phosphor sheet 70 or fluorescence 10 emitted from the absorptive region 4 of the biochemical analysis unit 1.
5 is condensed on the mirror 96 by the aspherical lens 97 provided in the optical head 95, and by the mirror 96,
The laser light 84 is reflected on the same side as the optical path, becomes parallel light, and enters the concave mirror 98.

The photostimulable light 105 or fluorescence 105 that has entered the concave mirror 98 is reflected by the concave mirror 98 and enters the perforated mirror 94.

Photostimulation 105 incident on the perforated mirror 94
Alternatively, as shown in FIG. 9, the fluorescent light 105 is reflected downward by a perforated mirror 94 formed by a concave mirror, enters the filter unit 108, cuts light of a predetermined wavelength, and photomultiplies. Prior 1
It is incident on 10 and is detected photoelectrically.

As shown in FIG. 9, the filter unit 108 includes four filter members 111a, 151b, and 1b.
The filter unit 10 includes 51c and 151d.
8 is configured to be movable in the left-right direction in FIG. 9 by a motor (not shown).

FIG. 10 is a schematic sectional view taken along the line AA of FIG.

As shown in FIG. 10, the filter member 1
11a includes a filter 112a, and the filter 112a
Is a filter used when exciting the fluorescent substance contained in the large number of absorptive regions 4 formed in the biochemical analysis unit 1 using the first laser excitation light source 81 and reading the fluorescence 105. It is a member, and has a property of cutting light having a wavelength of 640 nm and transmitting light having a wavelength longer than 640 nm.

FIG. 11 is a schematic sectional view taken along the line BB of FIG.

As shown in FIG. 11, the filter member 1
11b includes a filter 112b, and the filter 112b
Is a filter used when exciting the fluorescent substance contained in the large number of absorptive regions 4 formed in the biochemical analysis unit 1 using the second laser excitation light source 82 and reading the fluorescence 105. It is a member and has a property of cutting light having a wavelength of 532 nm and transmitting light having a wavelength longer than 532 nm.

FIG. 12 is a schematic sectional view taken along the line CC of FIG.

As shown in FIG. 12, the filter member 1
11c includes a filter 112c, and the filter 112c
Is used when the fluorescent substance contained in the large number of absorptive regions 4 formed in the biochemical analysis unit 1 is excited by using the third laser excitation light source 83 to read the fluorescence 105. It is a filter member, and has a property of cutting light having a wavelength of 473 nm and transmitting light having a wavelength longer than 473 nm.

FIG. 13 is a schematic sectional view taken along the line DD of FIG.

As shown in FIG. 13, the filter member 1
11d includes a filter 112d, and the filter 112d
Uses the first laser excitation light source 81 to excite a large number of stimulable phosphor layer regions 72 formed on the support 71 of the stimulable phosphor sheet 70 to generate a stimulable phosphor layer region 72. Is a filter used when reading the stimulable light 105 emitted from the stimulable phosphor layer region 72, and transmits only the light in the wavelength range of the stimulable light 105 and emits light having a wavelength of 640 nm. It has the property of cutting.

Therefore, depending on the laser excitation light source to be used, the filter members 111a, 151b, 151c,
By selectively positioning 151d in front of the photomultiplier 110, the photomultiplier 11
0 can photoelectrically detect only the light to be detected.

The photomultiplier 110 photoelectrically detects the photostimulable light 105, and the generated analog data is output to the A / D converter 113, digitized, and output to the data processing unit 114. It

FIG. 14 is a schematic plan view of the scanning mechanism of the optical head 95. In FIG. 14, for simplification, the optical system except the optical head 95 and the optical paths of the laser beam 84 and the fluorescent light 105 or the stimulating light 105 are omitted.

As shown in FIG. 14, the optical head 95
The scanning mechanism that scans the substrate includes a substrate 120.
Above the sub-scanning pulse motor 121 and the pair of rails 12
2, 62 are fixed, and a substrate 123 which is movable in the sub-scanning direction indicated by arrow Y in FIG. 14 is further provided on the substrate 120.

A threaded hole (not shown) is formed in the movable substrate 123, and a threaded rod 124 rotated by the sub-scanning pulse motor 121 is formed in this hole. Engaged.

The main scanning stepping motor 125 is provided on the movable substrate 123, and the main scanning stepping motor 125 attaches the endless belt 126 to the adjacent dot-shaped adsorptive properties formed in the biochemical analysis unit 1. The distance between the regions 4, that is, the stimulable phosphor sheet 70
Adjacent dot-shaped stimulable phosphor layer regions 7 formed in
It can be driven intermittently at a pitch equal to the distance between the two. The optical head 95 is the endless belt 1
It is fixed to the main scanning stepping motor 12
When the endless belt 126 is driven by 5,
In FIG. 14, it is configured to be moved in the main scanning direction indicated by arrow X. In FIG. 14, 67 is
Reference numeral 128 denotes a linear encoder 1 that detects the position of the optical head 95 in the main scanning direction.
27 slits.

Therefore, the main scanning stepping motor 1
25, the endless belt 126 is intermittently driven in the main scanning direction, and when scanning of one line is completed, the substrate 123 is intermittently moved in the sub scanning direction by the sub scanning pulse motor 121. In FIG. 14, the optical head 95 is moved in the main scanning direction indicated by the arrow X and in the sub-scanning direction indicated by the arrow Y, and all the dot-like shapes formed on the stimulable phosphor sheet 70 by the laser light 84 are moved. The entire surface of the photostimulable phosphor layer region 72 or the biochemical analysis unit 1 is scanned.

FIG. 15 is a block diagram showing the control system, input system, drive system and detection system of the scanner.

As shown in FIG. 15, the scanner control system includes a control unit 130 for controlling the operation of the entire scanner, and the scanner input system includes
The keyboard 131 that is operated by the user and can input various instruction signals is provided.

As shown in FIG. 15, the drive system of the scanner includes a main scanning stepping motor 125 for intermittently moving the optical head 95 in the main scanning direction, and an optical head 95.
Of the sub-scanning pulse motor 121 that intermittently moves the filter in the sub-scanning direction, and the four filter members 111a, 151b, 1
A filter unit motor 132 for moving the filter unit 108 including 51c and 151d is provided.

The control unit 130 selectively outputs a drive signal to the first laser excitation light source 81, the second laser excitation light source 82 or the third laser excitation light source 83, and also outputs a drive signal to the filter unit motor 132. It is configured to output.

As shown in FIG. 15, the detection system of the scanner includes a photomultiplier 110 and a linear encoder 127 for detecting the position of the optical head 95 in the main scanning direction.

In this embodiment, the control unit 130, in accordance with the position detection signal of the optical head 95 inputted from the linear encoder 127, the first laser excitation light source 81, the second laser excitation light source 82 or the third laser excitation light source 82. The laser excitation light source 83 is configured to be turned on / off.

The scanner according to the present embodiment configured as described above is recorded in a large number of dot-shaped stimulable phosphor layer areas 72 formed on the stimulable phosphor sheet 70 as follows. The radiation data obtained is read and biochemical analysis data is generated.

First, the stimulable phosphor sheet 70 is placed on the glass plate 101 of the stage 100.

Next, the keyboard 1 is selected by the user.
An instruction signal for scanning a large number of dot-shaped photostimulable phosphor layer regions 72 formed on the stimulable phosphor sheet 70 with a laser beam 84 is input to 31.

The instruction signal input to the keyboard 131 is input to the control unit 130, and the control unit 130 outputs a drive signal to the filter unit motor 132 in accordance with the instruction signal to move the filter unit 108 to activate it. 640 nm, which transmits only the light in the wavelength range of the photostimulable light 105 emitted from the luminescent phosphor.
Filter 112d having a property of cutting off light of wavelength
The filter member 111d provided with is placed in the optical path of the photostimulable light 105.

Further, the control unit 130 is
A drive signal is output to the main scanning stepping motor 125,
The optical head 95 is moved in the main scanning direction, and based on the position detection signal of the optical head 95 input from the linear encoder 127, the first stimulable phosphor layer region 72 is irradiated with the laser beam 84 at a position where it can be irradiated. When it is confirmed that the optical head 95 has moved, the main scanning stepping motor 12
A stop signal is output to 5 and a drive signal is output to the 1st laser excitation light source 81, the 1st laser excitation light source 81 is started, and the laser beam 84 of the wavelength of 640 nm is emitted.

The laser light 84 emitted from the first laser excitation light source 81 is made into parallel light by the collimator lens 85, and then enters the mirror 86 and is reflected.

Laser light 8 reflected by mirror 86
4 passes through the first dichroic mirror 87 and the second dichroic mirror 88, and enters the mirror 89.

The laser beam 84 incident on the mirror 89 is reflected by the mirror 89 and further incident on the mirror 92 to be reflected.

Laser light 8 reflected by mirror 92
4 passes through the hole 93 of the perforated mirror 94 and enters the concave mirror 98.

Laser light 84 incident on the concave mirror 98
Is reflected by the concave mirror 98, and the optical head 9
It is incident on 5.

Laser light 84 incident on the optical head 95
Is reflected by the mirror 96, and by the aspherical lens 97, the first stimulable phosphor layer region 7 of the stimulable phosphor sheet 70 placed on the stage 100 glass plate 101.
It is focused on 2.

As a result, the stimulable phosphor contained in the first stimulable phosphor layer region 72 formed on the support 71 of the stimulable phosphor sheet 70 is excited by the laser beam 84 to generate the first stimulable phosphor. The stimulable phosphor 105 is emitted from the stimulable phosphor layer region 72 of No. 1.

At this time, since the support 71 of the stimulable phosphor sheet 70 is made of nickel, the laser light 84 is scattered inside the support 71 and the first stimulable phosphor layer region 72 is formed. To excite the stimulable phosphor contained in the adjacent stimulable phosphor layer region 72, and effectively prevent the accumulated radiation energy from being emitted in the form of stimulable light 105. In addition, the stimulable light 105 emitted from the first stimulable phosphor layer region 72 is transferred to the support 71.
It is possible to effectively prevent the light from being scattered inside and not being detected by the photomultiplier 110.

The photostimulable light 105 emitted from the first photostimulable phosphor region 12 is condensed by the aspherical lens 97 provided in the optical head 95, and the same as the optical path of the laser light 84 by the mirror 96. It is reflected to the side and made into parallel light, and is incident on the concave mirror 98.

Photostimulation 105 incident on the concave mirror 98
Is reflected by the concave mirror 98 and enters the perforated mirror 94.

Photostimulable light 105 incident on the perforated mirror 94.
Is reflected downward by the perforated mirror 94 formed by the concave mirror and enters the filter 112d of the filter unit 108, as shown in FIG.

The filter 112d transmits only light in the wavelength region of the stimulable light 105 emitted from the stimulable phosphor,
Since it has the property of cutting light with a wavelength of 0 nm,
The light of the wavelength of 640 nm which is the excitation light is cut, and only the light of the wavelength range of the photostimulable light 105 emitted from the photostimulable phosphor layer region 72 is transmitted through the filter 112d, and the photomultiplier 110 photoelectrically converts the light. Detected.

The analog data photoelectrically detected and generated by the photomultiplier 110 is converted into analog data.
The data is digitized by the converter 113 and output to the data processing device 114.

After the first laser pumping light source 81 is turned on, when a predetermined time, for example, several microseconds has elapsed, the control unit 130 causes the first laser pumping light source 81 to operate.
And outputs a drive stop signal to the first laser excitation light source 81
Driving of the main scanning stepping motor 125 is stopped and the optical head 95 is
The stimulable phosphor sheet 70 is moved by a pitch equal to the distance between the adjacent dot-shaped stimulable phosphor layer regions 72 formed in the application 71 itself.

Based on the position detection signal of the optical head 95 inputted from the linear encoder 127, the optical head 9
5 is moved by one pitch equal to the distance between the adjacent dot-shaped stimulable phosphor layer regions 72, and the laser beam 84 emitted from the first laser excitation light source 81 is transferred to the stimulable phosphor sheet 70. Second stimulable phosphor layer region 7 formed
2 is confirmed to have moved to a position where irradiation can be performed on the first laser excitation light source 8
1 is turned on to turn on the first laser excitation light source 81, and the laser beam 84 is included in the second stimulable phosphor layer region 72 formed on the stimulable phosphor sheet 70. To excite the stimulable phosphor.

Similarly, the laser light 84 emitted from the first laser excitation light source 81 for a predetermined time is used as the second dot-shaped stimulable phosphor layer formed on the stimulable phosphor sheet 70. The region 72 is irradiated and the stimulable phosphor contained in the second stimulable phosphor layer region 72 is excited,
Photostimulable light 1 emitted from the second photostimulable phosphor layer region 72
05 was photoelectrically detected by the photomultiplier 110 to generate analog data, digitized by the A / D converter 113, and recorded in the second stimulable phosphor layer region 72. When the biochemical analysis data is generated from the radiation data, the control unit 130 outputs an OFF signal to the first laser excitation light source 81 to turn off the first laser excitation light source 81 and perform main scanning stepping. A drive signal is output to the motor 125 to move the optical head 95 by one pitch equal to the distance between the adjacent dot-shaped stimulable phosphor layer regions 72.

Thus, the first laser excitation light source 81 is repeatedly turned on and off in synchronization with the intermittent movement of the optical head 95, and based on the position detection signal of the optical head 95 inputted from the linear encoder 127, Optical head 95
Is moved by one line in the main scanning direction, and when it is confirmed that the scanning of the stimulable phosphor layer region 72 of the first line by the laser beam 84 is completed, the control unit 130 causes the main scanning A drive signal is output to the stepping motor 125 to return the optical head 95 to the original position, and a drive signal is output to the sub-scanning pulse motor 121 to move the movable substrate 123 by one line in the sub-scanning direction. Move only minutes.

On the basis of the position detection signal of the optical head 95 input from the linear encoder 127, the optical head 9
5 is returned to its original position and the movable substrate 123
However, when it is confirmed that the line has been moved by one line in the sub-scanning direction, the control unit 130 sequentially moves the first laser excitation light source to the stimulable phosphor layer region 72 of the first line. The laser light 84 emitted from the first laser excitation light source 81 is sequentially irradiated to the stimulable phosphor layer region 72 on the second line in the same manner as the irradiation of the laser light 84 emitted from the laser light 81. And the stimulable phosphor layer region 72
The stimulable phosphor contained in the photostimulable phosphor layer region 72 is excited to sequentially cause the photomultiplier 110 to photoelectrically detect the stimulable light 105 emitted from the stimulable phosphor layer region 72.

The analog data generated by being detected photoelectrically by the photomultiplier 110 is A / D.
Biochemical analysis data is generated from the radiation data output to the converter 113, digitized, and recorded in each dot-shaped stimulable phosphor layer region 72.

In this way, all the dot-shaped stimulable phosphor layer regions 72 formed on the support 71 of the stimulable phosphor sheet 70 are all irradiated by the laser light 84 emitted from the first laser excitation light source 81. The stimulable phosphor contained in the large number of dot-shaped stimulable phosphor layer regions 72 is excited, and the emitted stimulable light 105 is photoelectrically detected by the photomultiplier 110. The generated analog data is digitized by the A / D converter 113, and biochemical analysis data is generated from the radiation data recorded in each stimulable phosphor layer region 72. From 130, a drive stop signal is output to the first laser excitation light source 81, and the drive of the first laser excitation light source 81 is stopped.

On the other hand, when the fluorescence data of the fluorescent substance recorded in the numerous absorptive regions 4 formed in the biochemical analysis unit 1 is read to generate the biochemical analysis digital data, first, the user The biochemical analysis unit 1 is set on the glass plate 101 of the stage 100.

Then, the keyboard 1 is selected by the user.
The type of the fluorescent substance that is the labeling substance is specified and an instruction signal indicating that the fluorescence data should be read is input to 31.

The instruction signal input to the keyboard 131 is input to the control unit 130. When the control unit 130 receives the instruction signal, it follows the table stored in the memory (not shown).
The laser excitation light source to be used is determined, and which of the filters 112a, 112b, 112c is used for the fluorescence 105.
To be located in the optical path of.

For example, Rhodamine (registered trademark), which can be most efficiently excited by a laser having a wavelength of 532 nm, as a fluorescent substance for labeling a substance of biological origin
Is used and is input to the keyboard 131, the control unit 130 selects the second laser excitation light source 82, selects the filter 112b, and outputs a drive signal to the filter unit motor 132. To move the filter unit 108 to 532n
A filter member 111b provided with a filter 112b having a property of cutting light having a wavelength of m and transmitting light having a wavelength longer than 532 nm is located in the optical path of the fluorescence 105 to be emitted from the biochemical analysis unit 1. Let

Further, the control unit 130 is
A drive signal is output to the main scanning stepping motor 125,
The optical head 95 is moved in the main scanning direction, and based on the position detection signal of the optical head 95 input from the linear encoder, the first of the many absorptive regions 4 formed in the biochemical analysis unit 1 is detected. Laser light 8 is applied to the absorptive area 4.
When it is confirmed that the optical head 95 has reached the position where 4 can be irradiated, a stop signal is output to the main scanning stepping motor 125 and a drive signal is output to the second laser excitation light source 82, The second laser excitation light source 82 is activated to emit the laser light 84 having a wavelength of 532 nm.

The laser light 84 emitted from the second laser excitation light source 82 is made into parallel light by the collimator lens 90, then enters the first dichroic mirror 87 and is reflected.

The laser beam 84 reflected by the first dichroic mirror 87 passes through the second dichroic mirror 88 and enters the mirror 89.

The laser beam 84 incident on the mirror 89 is reflected by the mirror 89 and further incident on the mirror 92 to be reflected.

Laser light 8 reflected by mirror 92
4 passes through the hole 93 of the perforated mirror 94 and enters the concave mirror 98.

Laser light 84 incident on the concave mirror 98
Is reflected by the concave mirror 98, and the optical head 9
It is incident on 5.

Laser light 84 incident on the optical head 95
Is reflected by the mirror 96 and is condensed by the aspherical lens 97 on the biochemical analysis unit 1 mounted on the glass plate 101 of the stage 100.

As a result, the laser beam 84 excites a fluorescent substance such as a fluorescent dye contained in the first adsorptive region 4 of the biochemical analysis unit 1, for example, rhodamine to emit fluorescence.

Here, in the biochemical analysis unit 1 according to the present embodiment, the absorptive regions 4 are adsorbed in a large number of through holes 3 formed on the aluminum substrate 2 so as to be separated from each other. The fluorescent substance contained in the absorptive region 4 is formed by filling the absorptive region 4 with the substrate 2 made of aluminum having a property of attenuating light around the absorptive region 4. It is possible to reliably prevent the fluorescence 105 emitted from the fluorescent substance 105 from being mixed with the fluorescence 105 emitted from the fluorescent substance contained in the adsorbing regions 4 adjacent to each other.

The fluorescence 105 emitted from rhodamine is
The light is condensed by the aspherical lens 97 provided in the optical head 95, reflected by the mirror 96 to the same side as the optical path of the laser light 84, and made into parallel light, which is a concave mirror 98.
Incident on.

The fluorescent light 105 that has entered the concave mirror 98 is
The perforated mirror 94 is reflected by the concave mirror 98.
Incident on.

Fluorescent light 105 incident on the perforated mirror 94
Is reflected downward by the perforated mirror 94 formed by the concave mirror, and enters the filter 112b of the filter unit 108, as shown in FIG.

Since the filter 112b has a property of cutting light having a wavelength of 532 nm and transmitting light having a wavelength longer than 532 nm, light having a wavelength of 532 nm, which is excitation light, is cut and emitted from rhodamine. Fluorescence 1
Only light in the 05 wavelength range passes through the filter 112b,
It is detected photoelectrically by the photomultiplier 110.

The analog signal photoelectrically detected and generated by the photomultiplier 110 is output to the A / D converter 113 and converted into a digital signal.
It is output to the data processing device 114.

After the second laser excitation light source 82 is turned on, when a predetermined time, for example, several microseconds has elapsed, the control unit 130 causes the second laser excitation light source 82 to operate.
And outputs a drive stop signal to the second laser excitation light source 82.
Driving of the main scanning stepping motor 125 is stopped and the optical head 95 is
It is moved by a pitch equal to the distance between the absorptive regions 4 formed in the biochemical analysis unit 1.

On the basis of the position detection signal of the optical head 95 input from the linear encoder 127, the optical head 9
5 is moved by one pitch equal to the distance between the adsorbing regions 4 formed adjacent to each other in the biochemical analysis unit 1,
Laser light 84 emitted from the second laser excitation light source 82
Is confirmed to have moved to a position where the second absorptive region 4 formed in the biochemical analysis unit 1 can be irradiated, the control unit 130 sends a drive signal to the second laser excitation light source 82. By outputting, the second laser excitation light source 82 is turned on, and the laser light 84 excites the fluorescent substance contained in the second adsorptive region 4 formed in the biochemical analysis unit 1, for example, rhodamine. To do.

Similarly, the laser beam 84 is irradiated on the second absorptive region 4 formed in the biochemical analysis unit 1 for a predetermined time, and the fluorescence 105 emitted from the second absorptive region 4 is emitted. However, when the photomultiplier 110 photoelectrically detects and generates analog data, the control unit 130 outputs an off signal to the second laser pumping light source 82 to output the second laser pumping light source 82. Is turned off, and a drive signal is output to the main scanning stepping motor 125 to move the optical head 95 by one pitch equal to the distance between the adjacent absorptive regions 4 formed in the biochemical analysis unit 1. Let

In this way, the first laser pumping light source 81 is repeatedly turned on and off in synchronization with the intermittent movement of the optical head 95, and based on the position detection signal of the optical head 95 input from the linear encoder 127. , Optical head 9
5 is moved by one line in the main scanning direction, and when it is confirmed that all the absorptive regions 4 on the first line of the biochemical analysis unit 1 are scanned by the laser beam 84, control is performed. The unit 130 outputs a drive signal to the main scanning stepping motor 125, and the optical head 95
Is returned to the original position, and a drive signal is output to the sub-scanning pulse motor 121 to move the movable substrate 123.
Is moved by one line in the sub-scanning direction.

Based on the position detection signal of the optical head 95 inputted from the linear encoder 127, the optical head 9
5 is returned to its original position and the movable substrate 123
However, when it is confirmed that the line has been moved by one line in the sub-scanning direction, the control unit 130 sequentially advances to the absorptive region 4 of the first line formed in the biochemical analysis unit 1, The same as when the laser beam 84 emitted from the second laser excitation light source 82 is irradiated, the absorptive region on the second line 4 and the absorptive region on the second line formed in the biochemical analysis unit 1 Fluorescence emitted from the adsorptive region 4 by exciting rhodamine contained in
Are sequentially detected photoelectrically by the photomultiplier 110.

The analog data generated photoelectrically detected by the photomultiplier 110 is converted into analog data.
The data is converted into digital data by the converter 113 and sent to the data processing device 114.

In this way, the entire surface of the biochemical analysis unit 1 is scanned by the laser beam 84 emitted from the second laser excitation light source 82, and a large number of absorptive regions 4 formed in the biochemical analysis unit 1 are formed. Rhodamine contained therein is excited, the emitted fluorescence 105 is photoelectrically detected by the photomultiplier 110, and the generated analog data is converted into digital data by the A / D converter 113, When sent to the data processing device 114, the drive stop signal is output from the control unit 130 to the second laser excitation light source 82, and the drive of the second laser excitation light source 82 is stopped.

As described above, the biochemical analysis data is generated based on the radiation data and the fluorescence data recorded in the absorptive region 4 of the biochemical analysis unit 1.

Thus, in the biochemical analysis unit 1, the specific binding substance adsorbed in the absorptive region 4 is replaced with the substance of biological origin labeled with the labeling substance N times.
When hybridized and used for generation of biochemical analysis data, data regarding the date and time of execution of hybridization recorded in the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1, a radioactive label According to the data and the data on the radionuclides nuclides,
The biochemical analysis unit 1 is selected and stored and managed.

FIG. 16 is a schematic plan view of a biochemical analysis unit selection device which constitutes a biochemical analysis unit management system according to a preferred embodiment of the present invention.

As shown in FIG. 16, the biochemical analysis unit sorting apparatus which constitutes the management system of the biochemical analysis unit according to the present embodiment is provided with an endless belt 140 capable of carrying the biochemical analysis unit 1. The read head 141 for reading the magnetic data recorded in the magnetic recording layer 5 formed on the substrate 2 of the conveyed biochemical analysis unit 1 and the biochemical analysis unit 1 can be loaded by the endless belt 140. A biochemical analysis unit loading box 142 equipped with a biochemical analysis unit sending mechanism (not shown) for sending the biochemical analysis units 1 onto the endless belt 140 one by one,
A first chute 144a, a second chute 144b, ..., And an nth chute 144n are provided along one side of the endless belt 140.

The first chute 144a, the second chute 144b, ..., And the n-th chute 144n respectively collect the biochemical analysis unit 1 according to the time when they can be discarded. 1
45a, biochemical analysis unit collection box 145b,
... and the biochemical analysis unit recovery box 145n are configured to be selectively connectable to the endless belt 140.
At the downstream end of the, the specific binding substance adsorbed in the adsorptive region 4 is brought into contact with a fluorescent substance and / or a chemiluminescent substrate without being hybridized with a substance of biological origin labeled with a radioactive labeling substance. A substance derived from a living body that is labeled with a labeling substance that produces chemiluminescence by being hybridized N times and collects the biochemical analysis unit 1 used to generate biochemical analysis data. A box 147 is provided.

As shown in FIG. 16, a first chute 144a, a second chute 144b, ... And an nth chute 144 are provided on the other side of the endless belt 140.
n is projected on the endless belt 140, is placed on the upper surface of the endless belt 140, and pushes the conveyed biochemical analysis unit 1 to push the first chute 144a, the second chute 144b, ... And a first sorting member 148a sent to the nth chute 144n,
Second sorting member 148b, ... And nth sorting member 14
8n are provided.

Here, the first sorting member 148a, the second sorting member 148b, ... And the nth sorting member 148n.
Are driven by the first solenoid 150a, the second solenoid 150b, ... And the nth solenoid 150n, respectively, and are projected onto the endless belt 140.

FIG. 17 is a block diagram showing a control system, a detection system, a drive system and an input system of a biochemical analysis unit selection device which constitutes a management system for a biochemical analysis unit according to a preferred embodiment of the present invention. is there.

As shown in FIG. 17, the control system of the biochemical analysis unit sorting apparatus has a control unit 160 for controlling the operation of the entire biochemical analysis unit sorting apparatus.
The detection system of the biochemical analysis unit selection device includes a reading device that reads the magnetic data recorded in the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 placed on the endless belt 140. The head 141 is provided.

As shown in FIG. 17, the drive system of the biochemical analysis unit selection device comprises an endless belt motor 161 for driving the endless belt 140, and a biochemical unit loaded in the biochemical analysis unit loading box 142. Endless belt 140 for each analysis unit 1
Unit for sending out biochemical analysis unit 162
And a first solenoid 150a for driving the first sorting member 148a, a second solenoid 150b for driving the second sorting member 148b, ..., And an nth sorting member 148n.
The input system of the biochemical analysis unit selection device is provided with a keyboard 163.

The biochemical analysis unit sorting apparatus configured as described above sorts the used biochemical analysis unit 1 in the following manner, and uses the first chute 144a, the second chute 144b, … Or the nth shoot 14
Biochemical analysis unit collection box 14 via 4n
5a, biochemical analysis unit collection box 145b, ...
Alternatively, it is recovered in the biochemical analysis unit recovery box 145n or the disposal box 147.

First, for the first chute 144a, the second chute 144b, ... And the nth chute 144n,
Biochemical analysis unit collection box 145
a, a biochemical analysis unit collection box 145b, ... And a biochemical analysis unit collection box 145n are connected. In this embodiment, the biochemical analysis unit 1 is collected in different biochemical analysis unit collection boxes 145a, 145b, ...

A biochemical analysis unit recovery box 145a, a biochemical analysis unit recovery box 145b, ..., and a biochemical analysis unit recovery box 145a are provided on the first chute 144a, the second chute 144b, ... When the unit collection box 145n is connected,
User selects biochemical analysis unit collection box 145
a, biochemical analysis unit recovery box 145b, ... and biochemical analysis unit recovery box 145n, the data concerning the disposal date for specifying the disposal date of the biochemical analysis unit 1 to be recovered respectively. To
Input on the keyboard 163.

Next, a predetermined number of used biochemical analysis units 1 are replaced with biochemical analysis unit loading boxes 1.
It is loaded in the keyboard 42 and an operation start signal is input to the keyboard 163.

When the operation start signal is input to the keyboard 163, the operation start signal is transmitted to the control unit 160.
The control unit 160 outputs a drive signal to the endless belt motor 161 to drive the endless belt 140, and also outputs a drive signal to the biochemical analysis unit delivery mechanism 162 to output the biochemical analysis unit. The biochemical analysis unit 1 loaded in the loading box 142 is attached to the endless belt 1 one by one.
40 to send out.

The biochemical analysis unit 1 delivered onto the endless belt 140 is conveyed by the endless belt 140 and delivered to the reading head 141.

When the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 reaches the position facing the read head 141, the control unit 160 outputs a drive stop signal to the endless belt motor 161. ,
The endless belt 140 is stopped and the reading head 1
The magnetic data recorded on the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 is read by 41.

The data read by the reading head 141 is output to the control unit 160.

When magnetic data is input from the read head 141, the control unit 160 determines whether or not the data input from the read head 141 includes radioactive label data.

As a result, when the data inputted from the reading head 141 does not include the radiolabeled data and it is not recognized that the radiolabeled substance was used during the hybridization, the biochemical data of the radiolabeled substance was detected. Since the analysis unit 1 can be immediately discarded, the control unit 160 operates as an endless belt motor 161.
To drive the endless belt 140 to output the biochemical analysis unit 1 to the endless belt 14
0 is collected in the waste box 147 provided at the downstream end.

On the other hand, when the data input from the reading head 141 includes the radiolabeled data and it is recognized that the radiolabeled substance was used during the hybridization, the control unit 160 is used.
Reads the reference data for each radionuclide of the radiolabeled substance stored in the memory (not shown), and
It is included in the absorptive region 4 of the biochemical analysis unit 1 based on the data regarding the execution date and time of the hybridization of the biochemical analysis unit 1 inputted from 41, the radiolabeling data and the data regarding the nuclide of the radiolabeled substance. The radioactivity level of the radiolabeled substance decays to a level below the level at which the biochemical analysis unit 1 can be discarded. The time to discard the biochemical analysis unit 1 is calculated, and the calculated time to discard the biochemical analysis unit 1 is calculated. And based on the date of disposal stored in memory,
Of the selection member 148a, the second selection member 148b, ..., And the nth selection member 148n to be driven, and to send the biochemical analysis unit 1 to a position facing the selection member. The required driving time of the endless belt 140 is calculated.

Next, the control unit 160
A drive signal is output to the endless belt motor 161 to drive the endless belt 140, and when the calculated drive time of the endless belt 140 has elapsed, a drive stop signal is output to the endless belt motor 161 to output the endless belt motor 161. The belt 140 is stopped, and the first sorting member 148a, the second sorting member 148b, ... Determined based on the disposal time of the biochemical analysis unit 1 are determined.
Alternatively, a drive signal is output to the first solenoid 150a, the second solenoid 150b, ... Or the nth solenoid 150n that drives the nth sorting member 148n, and the first sorting member 148a and the second sorting member 148b are output. , Or the n-th selection member 148n is driven to move the biochemical analysis unit 1 to the first chute 144a, the second chute 144b, ...
Into a chute 144n of the biochemical analysis unit recovery box 145a, 1 connected to the chute 144n.
45b, ... Or collected in 145n.

Similarly, the control unit 160
Records the biochemical analysis unit 1 loaded in the biochemical analysis unit loading box 142 one by one onto the endless belt 140, and records the biochemical analysis unit 1 on the magnetic recording layer 5 of the biochemical analysis unit 1. Based on the data on the execution date and time of the hybridization and the data on the nuclide of the radiolabeled substance used, the radioactivity level of the radiolabeled substance contained in the adsorptive region 4 of the biochemical analysis unit 1 is Calculate the disposal time of the biochemical analysis unit 1 that attenuates the biochemical analysis unit 1 below the level at which it can be discarded, and calculate the biochemical analysis unit 1
Biochemical analysis unit recovery box 145a, 1 in which the biochemical analysis unit 1 should be recovered based on the data regarding the disposal time and the disposal date stored in the memory.
45b, ... Or 145n is determined and the corresponding first
Driving the sorting member 148a, the second sorting member 148b, ... Or the nth sorting member 148n, and performing the biochemical analysis via the first chute 144a, the second chute 144b, ... Or the nth chute 144n. Unit 1
The determined biochemical analysis unit recovery box 145
a, 145b, ... Or 145n to sort, collect.

In this way, all biochemical analysis units 1 loaded in the biochemical analysis unit loading box 142 are selected, and the biochemical analysis unit recovery box 1 is selected.
45a, 145b, ... Or 145n or the waste box 147, the operation end signal is input to the keyboard 163 and the endless belt motor 20
1 driving is stopped, the biochemical analysis unit 1 is selected,
Collection is complete.

As described above, the radioactivity level of the radiolabeled substance contained in the adsorptive region 4 of the biochemical analysis unit 1 attenuates to a level below the level at which the biochemical analysis unit 1 can be discarded. Depending on the disposal time of the chemical analysis unit 1, the biochemical analysis unit collection boxes 145a, 145a, 14 connected to the first chute 144a, the second chute 144b, ... Or the nth chute 144n.
The biochemical analysis unit 1 collected in 5b, ... Or 145n is stored in the biochemical analysis unit collection box 145 until the calculated disposal time of the biochemical analysis unit 1.
a, 145b, ... Or 145n are stored, and are discarded when the discard time is reached.

According to this embodiment, the magnetic recording layer 18 formed on the substrate 2 of the biochemical analysis unit 1 is moved by the magnetic recording head 18 of the hybridization apparatus 10 to
Data on the number of times of hybridization, data on the date and time at which hybridization was performed using the biochemical analysis unit 1, and when a radiolabeled substance was used as a labeling substance during hybridization, radioactivity A unit for biochemical analysis in which radiolabeling data indicating that a labeling substance has been used and data regarding a radionuclide of the radiolabeling substance are recorded, and hybridization is performed N times based on the data regarding the number of times of hybridization 1 is based on the data concerning the execution date and time of the hybridization recorded in the magnetic recording layer 5 of the biochemical analysis unit 1 by the biochemical analysis unit selection device, the radiolabeled data and the data on the nuclide of the radiolabeled substance,
The radioactivity level of the radiolabeled substance contained in the adsorptive region 4 of the biochemical analysis unit 1 is attenuated to a level below the level at which the biochemical analysis unit 1 can be discarded. The biochemical analysis unit 1 is selected and stored and managed according to the calculated disposal time of the biochemical analysis unit 1. Therefore, the used biochemical analysis unit 1 can be used for biochemical analysis. Unit 1
The radioactive level of the radiolabeled substance contained in the adsorptive region 4 of the biochemical analysis unit 1 decays to a level below the level at which the biochemical analysis unit 1 can be discarded. Then, the radioactive level of the radiolabeled substance contained in the adsorptive region 4 of the biochemical analysis unit 1 can be discarded after the biochemical analysis unit 1 has decayed to a level below the level at which the biochemical analysis unit 1 can be discarded. Become.

FIG. 18 is a schematic perspective view of a biochemical analysis unit managed by a biochemical analysis unit management system according to another preferred embodiment of the present invention.

As shown in FIG. 18, the biochemical analysis unit 171 managed by the biochemical analysis unit management system according to this embodiment has an absorptive substrate 172 formed of nylon 6.

For the biochemical analysis, the absorptive substrate 172 of the biochemical analysis unit 171 shown in FIG.
With the spotting device shown in FIG.
A solution containing a specific binding substance such as is dropped to form a plurality of spot-shaped regions that are separated from each other.

FIG. 19 is a plan view of the adsorptive substrate 172 of the biochemical analysis unit 171 which is c by a spotting device.
FIG. 6 is a schematic perspective view of a biochemical analysis unit 171 in which a solution containing a specific binding substance such as DNA is dropped and a plurality of spot-shaped regions separated from each other are formed.

As shown in FIG. 19, a solution containing a specific binding substance such as cDNA is dropped onto the absorptive substrate 172 of the biochemical analysis unit 171 to form a plurality of spot-like regions 174 separated from each other. Has been formed.

Although not shown exactly in FIG. 19,
On the absorptive substrate 172 of the biochemical analysis unit 171,
The approximately circular spot-like regions 174 having a size of about 0.01 square millimeters of about 10,000 are regularly formed at a density of about 5000 pieces / square centimeter.

FIG. 20 is a schematic side view of a hybridization apparatus which constitutes a management system for a biochemical analysis unit according to another preferred embodiment of the present invention, and FIG. 21 is its control system and detection system. 2 is a block diagram of a drive system, an input system, and a display system.

As shown in FIGS. 20 and 21, in the hybridization apparatus 180 which constitutes the management system of the biochemical analysis unit according to this embodiment, it is formed on the substrate 2 of the biochemical analysis unit 1. Magnetic recording head 18 for writing magnetic data on the magnetic recording layer 5
Instead of the absorptive substrate 1 of the biochemical analysis unit 171
72, data relating to the date and time at which the hybridization is carried out, when a radiolabeled substance is used as the labeling substance during the hybridization, the radiolabeled data and the radiolabeled substance showing that the radiolabeled substance was used. A print head 188 that prints data relating to nuclides is provided, and instead of the read head 17 that reads the magnetic data recorded in the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1, biochemical analysis is performed. It has the same configuration as the hybridization apparatus shown in FIGS. 3 and 5, except that an optical reading head 187 for reading the data printed on the absorptive substrate 172 of the unit 171 is provided. .

In the hybridization device 180 according to the present embodiment configured as described above, the data regarding the date and time when the hybridization is executed,
Data on the number of times the biochemical analysis unit 1 was used for hybridization, and when a radiolabeled substance was used as a labeling substance during hybridization, radiolabeled data indicating that a radiolabeled substance was used , Data on radionuclides nuclides,
Using the print head 188, the biochemical analysis unit 17
1 is printed on the absorptive substrate 172, and these data are
Except for being optically read by the optical read head 187, a large number of absorptive substrates 172 of the biochemical analysis unit 171 are formed in the same manner as the hybridization apparatus 10 shown in FIGS. 3 and 5. The specific binding substance contained in the spot-shaped region 174 is selectively hybridized with a substance of biological origin labeled with a radioactive labeling substance contained in the probe solution and a substance of biological origin labeled with a fluorescent substance. Be soybeans.

Thus, the radiation data of the radioactive labeling substance as the labeling substance and the fluorescence data of the fluorescent substance such as the fluorescent dye are recorded in the large number of spot-like regions 174 of the biochemical analysis unit 171. The fluorescence data recorded in the spot-shaped region 174 is read by the scanner shown in FIGS. 8 to 15 in exactly the same manner as in the above-described embodiment, and biochemical analysis data is generated.

On the other hand, the radiation data of the radiolabeled substance is
The stimulable phosphor sheet 90 transferred to the stimulable phosphor sheet 90 shown in FIG.
The radiation data transferred onto the scanner is read by the scanner shown in FIGS. 8 to 15 to generate biochemical analysis data.

Thus, the biochemical analysis unit 171
However, if the specific binding substance contained in the spot-shaped region 174 is a substance of biological origin labeled with a labeling substance,
Once hybridized and used to generate biochemical analysis data, the biochemical analysis unit 17
The biochemical analysis unit 171 is selected and stored and managed according to the data regarding the execution date and time of the hybridization, the radiolabeling data, and the data regarding the nuclide of the radiolabeled substance, which are printed on the first absorptive substrate 172.

FIG. 22 is a schematic plan view of a biochemical analysis unit selection device constituting a management system for biochemical analysis units according to another preferred embodiment of the present invention, and FIG. 23 is a control system thereof. It is a block diagram showing a detection system, a drive system, and an input system.

As shown in FIG. 22 and FIG. 23, the biochemical analysis unit selection device which constitutes the management system of the biochemical analysis unit according to this embodiment is formed on the substrate 2 of the biochemical analysis unit 1. Head 14 for reading the magnetic data recorded on the recorded magnetic recording layer 5
Instead of No. 1, an optical reading head 191 for reading the data regarding the execution date and time of hybridization, the radiolabeling data and the data regarding the nuclide of the radiolabeled substance, which are printed on the adsorptive substrate 172 of the biochemical analysis unit 171, is provided. 16 and 17 except
It has the same structure as the biochemical analysis unit selection device shown in FIG.

In the biochemical analysis unit sorting apparatus according to this embodiment having the above-described structure, the read head 141 records data on the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1. Instead of the magnetic data being read, an optical read head 191
According to the absorptive substrate 1 of the biochemical analysis unit 171
Except that the data regarding the date and time of execution of hybridization, the radiolabeling data, and the data regarding the radionuclide of the radiolabeled substance, which are printed on 72, are read, the unit selecting apparatus for biochemical analysis shown in FIGS. Similarly, the radioactivity level of the radiolabeled substance contained in the spot-shaped region 174 of the biochemical analysis unit 171 is attenuated to a level below the level at which the biochemical analysis unit 171 can be discarded. The biochemical analysis unit 171 is selected according to the disposal time of the first chute 144a and the second chute 1
44b, ... Or via the nth shoot 144n,
The biochemical analysis unit 1 is set to the determined biochemical analysis unit collection box 145a, 145b, ... Or 14
Recovered within 5n.

According to this embodiment, the print head 188 of the hybridization device 180 uses the data concerning the number of times of hybridization on the absorptive substrate 172 of the biochemical analysis unit 171. Therefore, the data regarding the date and time when the hybridization was performed, the radiolabeled data indicating that the radiolabeled substance was used when the radiolabeled substance was used as the labeling substance during the hybridization, and the radiolabeled substance The biochemical analysis unit 171 on which the data on the nuclide has been printed and the hybridization has been performed N times based on the data on the number of times of hybridization is detected by the optical read head 191 of the biochemical analysis unit selection device. Biochemical analysis Absorptive substrate 172 of the unit 171
The data regarding the execution date and time of hybridization, the radiolabeling data and the data regarding the radionuclide of the radiolabeled substance, which are printed on the plate, are read, and the radioactivity contained in the spot-like region 174 of the biochemical analysis unit 171 is read based on the read data. The radioactivity level of the labeling substance is attenuated below the level at which the biochemical analysis unit 171 can be discarded. The disposal time of the biochemical analysis unit 1 is calculated, and the disposal time of the biochemical analysis unit 1 is calculated according to the calculated disposal time. Since the biochemical analysis unit 171 is selected and stored and managed, the used biochemical analysis unit 171 is used to emit the radiolabeled substance contained in the spot-shaped region 174 of the biochemical analysis unit 171. The level of activity is reduced to below the level at which the biochemical analysis unit 171 can be discarded. To waste the time of the analysis unit 1, securely, and store management, biochemical analysis unit 171
After the radioactivity level of the radiolabeled substance contained in the spot-shaped region 174 of the biochemical analysis unit 1 is attenuated to a level below the level at which the biochemical analysis unit 1 can be discarded, the unit can be discarded.

FIG. 24 shows the stimulable phosphor contained in the stimulable phosphor layer region 72 formed on the stimulable phosphor sheet 70 shown in FIG. 6 in the biochemical analysis unit 1. It is a schematic perspective view of the exposure apparatus which exposes with the radioactive labeling substance selectively contained in the formed absorptive area | region 4.

As shown in FIG. 24, the exposure apparatus for the stimulable phosphor sheet 70 according to the present embodiment is provided with a casing 200 and a lid member 201. Inside the casing 200, the biochemical analysis unit 1 and A substrate 202 on which the stimulable phosphor sheet 70 is placed is provided. The casing 200 and the lid member 201 are formed of metal having a property of attenuating radiation.

As shown in FIG. 8, a data reading / recording unit 203 is provided on the lid member 201 of the exposure apparatus, and the data reading / recording unit 203 includes a read head (not shown) and a magnetic recording unit. It has a head (not shown).

FIG. 25 is a schematic partial cross-sectional view showing a mechanism for locking the lid member of the exposure apparatus for the stimulable phosphor sheet to the casing.

As shown in FIG. 25, the lid member 201
A lid member locking mechanism that locks the above with the casing 200 is provided on both sides of the lid member 201, and one of them is shown in FIG. 25.

As shown in FIG. 25, the locking mechanism of the lid member 201 includes a hook member 205 provided inside both side portions of the lid member 201, a hook member 205 around the shaft 205a, and a clockwise direction in FIG. It is provided with a compression spring 206 that urges the casing 200, and an engagement groove 207 provided inside the side plate of the casing 200.

When the lid member 201 is closed, the hook member 205 is urged by the spring force of the compression spring 206 and engages with the engaging groove 207 provided in the casing 200, so that the lid member 201 is closed. It is configured to be locked.

The lid member locking mechanism further includes a lid member 20.
25, the hook member 205 is swung in the counterclockwise direction around the shaft 205a in the counterclockwise direction in FIG. A solenoid 208 for releasing the engagement with is provided.

FIG. 26 is a block diagram showing a control system, a detection system, a drive system, a display system and an input system of the exposure apparatus for the stimulable phosphor sheet.

As shown in FIG. 26, the control system of the exposure apparatus for the stimulable phosphor sheet includes a control unit 210 for controlling the entire exposure apparatus, and the detection system of the exposure apparatus for the stimulable phosphor sheet is a raw system. A read head 211 of a data reading / recording unit 203 for reading data recorded on the magnetic recording layer 5 of the chemical analysis unit 1 is provided,
The read signal of the read head 211 is configured to be input to the control unit 210.

As shown in FIG. 26, the drive system of the exposure apparatus for the stimulable phosphor sheet is a data reading / writing unit for writing magnetic data to the magnetic recording layer 5 of the biochemical analysis unit 1.
A magnetic recording head 212 of the recording unit 203, a solenoid 208 for releasing a lid member locking mechanism, and a display system of the exposure apparatus for the stimulable phosphor sheet include a display panel 213 composed of a liquid crystal panel or the like.

As shown in FIG. 26, the input system of the exposure apparatus for the stimulable phosphor sheet comprises a keyboard 215,
The input system of the exposure apparatus for the stimulable phosphor sheet includes a lid member opening button 214.

Radioactive label in which the dot-shaped stimulable phosphor layer region 72 formed on the stimulable phosphor sheet 70 is included in the dot-shaped absorptive region 4 formed in the biochemical analysis unit 1. When exposing with a substance, first
Data relating to the nuclide of the radiolabeled substance used is input to the keyboard 215, and then the lid member opening button 214 is operated.

When the lid member release button 214 is operated,
The lid member opening signal is input to the control unit 210, and when the control unit 210 receives the lid member opening signal, the control unit 210 outputs a drive signal to the solenoid 208.

As a result, the solenoid 208 is driven and the hook member 205 is swung in the clockwise direction in FIG. 25 around the shaft 105a against the biasing force of the compression spring 206, so that the hook member 205 is separated from the hook member 205. Engagement groove 207
Is disengaged, and the lid member 201 of the exposure apparatus is opened.

When the lid member 201 of the exposure apparatus is opened,
The biochemical analysis unit 1 is set by the user on the substrate 202 of the exposure apparatus, and the lid member 201 is closed.

In this embodiment, magnetic data is not written in the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 by the hybridization device 10, and the exposure device exposes the biochemical analysis unit 1 to the magnetic recording layer 5. The magnetic data is written on the magnetic recording layer 5 formed on the substrate 2 of the exposure apparatus. Therefore, the data reading / recording unit 203 of the exposure apparatus is the read head 2
The magnetic data recorded on the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 can be read by 11, and the magnetic data can be formed on the substrate 2 of the biochemical analysis unit 1 by the magnetic recording head 212. Magnetic recording layer 5
In order to write the magnetic data, the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 set on the substrate 202 is opposed to the magnetic recording layer 5 when the lid member 201 is closed. In addition, the lid member 201 is provided.

When the lid member 201 is closed, the reading head 211 of the data reading / recording unit 203 is, if necessary, recorded on the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1. The ID data is read and a detection signal is output to the control unit 210.

Then, the control unit 210
Based on the built-in clock, data relating to the date and time when the exposure operation is performed and radioactive label data are generated and output to the magnetic recording head 212 to form the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1. And the data on the nuclide of the radiolabeled substance input to the keyboard 215 is written on the magnetic recording layer 5.

When the writing of the magnetic data is completed, the lid member 201 is opened, the stimulable phosphor sheet 70 is overlaid on the biochemical analysis unit 1, and the lid member 201 is closed.

In this way, by stacking the biochemical analysis unit 1 and the stimulable phosphor sheet 70 for a predetermined time, the biochemical analysis unit 1 is selectively included in a large number of absorptive regions 4 of the biochemical analysis unit 1. The radioactive labeling substance exposes the stimulable phosphor contained in the many stimulable phosphor layer regions 72 of the stimulable phosphor sheet 70.

As a result, radiation data is recorded in the stimulable phosphor layer area 72 of the stimulable phosphor sheet 70.

The radiation data recorded in the stimulable phosphor layer area 72 of the stimulable phosphor sheet 70 is read by the scanner shown in FIGS. Data for chemical analysis is generated.

On the other hand, the biochemical analysis unit 1 is shown in FIG.
And it is sorted and collected by the biochemical analysis unit sorter shown in FIG.

In the present embodiment, the biochemical analysis unit 1 is read by the read head 141 instead of the data regarding the date and time of hybridization, the radiolabeling data and the data regarding the nuclide of the radiolabeled substance.
The data regarding the date and time when the exposure operation is performed, the radiolabel data and the data regarding the nuclide of the radiolabel substance recorded in the magnetic recording layer 5 formed on the substrate 2 are read and output to the control unit 160.

The control unit 160 is included in the adsorptive region 4 of the biochemical analysis unit 1 on the basis of the input date and time data for executing the exposure operation, the radiolabeling data and the radionuclide nuclide data. The radioactivity level of the radiolabeled substance is reduced below the level at which the biochemical analysis unit 1 can be discarded. Calculate the disposal time of the biochemical analysis unit 1 and calculate the calculated disposal time of the biochemical analysis unit 1. According to the above, the endless belt motor 16
1, first solenoid 150a, second solenoid 15
0b, ... And the nth solenoid 150n are controlled to select and collect the biochemical analysis unit 1.

According to the present embodiment, the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 is subjected to the data concerning the date and time when the exposure operation is performed by the magnetic recording head 212 of the exposure device, and the radioactive label. The data and the data on the radionuclide of the radiolabeled substance are recorded, and the data on the execution date and time of the hybridization recorded on the magnetic recording layer 5 of the biochemical analysis unit 1 by the biochemical analysis unit selection device, the radiolabeled data and Based on the data on the radiolabeled nuclide, the radioactivity level of the radiolabeled substance contained in the adsorptive region 4 of the biochemical analysis unit 1 is attenuated to a level below the level at which the biochemical analysis unit 1 can be discarded. Biochemical analysis unit 1
The disposal time of the biochemical analysis unit 1 is calculated according to the calculated disposal time of the biochemical analysis unit 1.
Are sorted and stored and managed, the used biochemical analysis unit 1 is used for the biochemical analysis when the radioactivity level of the radiolabeled substance contained in the adsorptive region 4 of the biochemical analysis unit 1 is changed. The biochemical analysis unit 1 will be stored and managed until the disposal time of the biochemical analysis unit 1 that decays below the level at which it can be discarded, and the radiolabeled substance contained in the absorptive region 4 of the biochemical analysis unit 1 It becomes possible to discard the biochemical analysis unit 1 after the radioactivity level decays to a level below the level at which the biochemical analysis unit 1 can be discarded.

The present invention is not limited to the above embodiments, and various modifications can be made within the scope of the invention described in the claims, and these are also included in the scope of the present invention. It goes without saying that it is a thing.

For example, in the embodiment shown in FIGS. 1 to 17, data relating to the radionuclide nuclide is recorded on the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1, 18 to 23, the data on the nuclide of the radiolabeled substance is stored in the adsorptive substrate 172 of the biochemical analysis unit 171.
On the substrate 2 of the biochemical analysis unit 1 by the read head 141 of the biochemical analysis unit selection device.
The data regarding the execution date and time of the hybridization and the data regarding the nuclide of the radiolabeled substance recorded in the magnetic recording layer 5 formed on the substrate are read, or the biochemical analysis is performed by the optical read head 191 of the biochemical analysis unit selection device. Board 17 of the unit 171
By reading the data on the date and time of execution of hybridization and the data on the nuclide of the radiolabeled substance printed in 2, the radioactivity level of the radiolabeled substance contained in the unit for biochemical analysis 1 Although the biochemical analysis unit 1 is decayed to a level below the level at which it can be discarded, the disposal time of the biochemical analysis unit 1 is calculated and the biochemical analysis unit 1 is selected. When the nuclide of the radiolabeled substance used to label the radiolabeled substance is known, the data on the nuclide of the radiolabeled substance is recorded to the magnetic recording layer 5 or the biochemical analysis unit formed on the substrate 2 of the biochemical analysis unit 1. 17
The radionuclide of the radiolabeled substance used for labeling the used biochemical analysis unit 1 without recording on the absorptive substrate 172 of No. 1 is input to the keyboard 163 of the biochemical analysis unit selection device, Based on the data on the date and time of hybridization and the data on the nuclide of the radiolabeled substance, the radioactivity level of the radiolabeled substance contained in the biochemical analysis unit 1 is below the level at which the biochemical analysis unit 1 can be discarded. Even when the disposal time of the biochemical analysis unit 1 which is attenuated is calculated and the biochemical analysis unit 1 is selected, or the user himself / herself is printed on the absorptive substrate 172 of the biochemical analysis unit 171. Data about the date and time of execution of hybridization Based on the nuclide radioactive labeling substance used to label the used biochemical analysis unit 171, absorptive substrate 17 of the biochemical analysis unit 171
The radioactivity level of the radiolabeled substance contained in 2 decays to below the level at which the biochemical analysis unit 1 can be discarded. The disposal time of the biochemical analysis unit 1 is calculated, and the biochemical analysis unit 171 is calculated. May be selected.

Further, in the embodiment shown in FIGS. 20 to 23, the hybridization device 180 is used.
Of the number of hybridizations on the absorptive substrate 172 of the biochemical analysis unit 171 in which a large number of spot-like regions 174 containing a specific binding substance are formed by the print head 188 of the biochemical analysis unit 171. The data on the date and time when the hybridization was carried out using, and when a radiolabeled substance was used as a labeling substance during the hybridization, the radiolabeled data and the radiolabeled data showing that the radiolabeled substance was used. Data regarding the nuclide of the substance is printed, and the data regarding the execution date and time of the hybridization, which is printed by the optical reading head 191 of the biochemical analysis unit selection device on the adsorptive substrate 172 of the biochemical analysis unit 171 and the radiolabeled data. And of radiolabeled substances Reading data relating to species, based on the read data, the biochemical analysis unit 171
The disposal time when the radioactivity level of the radiolabeled substance contained in the spot-shaped area 174 of the biochemical analysis unit 171 is attenuated to a level below the level at which the biochemical analysis unit 171 can be discarded is calculated, and the biochemical analysis is performed according to the calculated disposal time. Analysis unit 1
71 is selected and stored and managed, but as shown in FIG. 1, a raw material in which absorptive regions 4 are densely formed in a large number of substantially circular through holes 3. Data indicating the date and time when the hybridization was performed on the substrate 2 of the chemical analysis unit 1, and when a radioactive labeling substance was used as the labeling substance during hybridization, it indicates that the radioactive labeling substance was used. Data on the date and time of hybridization printed on the substrate 2 of the biochemical analysis unit 1 by printing the radiolabeled data and the data on the nuclide of the radiolabeled substance and by the optical reading head 191 of the biochemical analysis unit selection device. , Radiolabeled data and radionuclide data of radiolabeled substances were read, and based on the read data, production was started. It was selected analysis unit 1 may be stored and managed.

In the embodiment shown in FIGS. 20 to 23, the biochemical analysis unit in which a large number of spot-shaped regions 174 containing a specific binding substance are formed by the print head 188 of the hybridization device 180. On the adsorptive substrate 172 of 171, data on the number of times of hybridization, data on the date and time at which hybridization was performed using the biochemical analysis unit 171, and at the time of hybridization,
When a radioactive labeling substance is used as the labeling substance,
Radioactive labeling data indicating that the radiolabeled substance was used and data relating to the nuclide of the radiolabeled substance are printed, and the absorptive substrate 172 of the biochemical analysis unit 171 is read by the optical reading head 191 of the biochemical analysis unit selection device. The data regarding the date and time of execution of hybridization, the radiolabeling data, and the data regarding the nuclide of the radiolabeled substance, which are printed on the plate, are read, and the radiation contained in the spot-like region 174 of the biochemical analysis unit 171 is read based on the read data. Noh level is
The disposal time at which the biochemical analysis unit 171 is attenuated to a level below the level at which disposal is possible is calculated, and the biochemical analysis unit 171 is selected according to the calculated disposal time.
It is configured to be stored and managed, but the user himself, without using the biochemical analysis unit sorting device,
According to the data regarding the execution date and time of the hybridization printed on the adsorptive substrate 172 of the biochemical analysis unit 171, the radiolabeling data and the data regarding the nuclide of the radiolabeled substance, the biochemical analysis unit 1
71 may be selected and stored and managed.

Further, in the embodiment shown in FIGS. 20 to 23, the hybridization device 180 is used.
Of the number of hybridizations on the absorptive substrate 172 of the biochemical analysis unit 171 in which a large number of spot-like regions 174 containing a specific binding substance are formed by the print head 188 of the biochemical analysis unit 171. The data on the date and time when the hybridization was carried out using, and when a radiolabeled substance was used as a labeling substance during the hybridization, the radiolabeled data and the radiolabeled data showing that the radiolabeled substance was used. Although the data on the nuclide of the substance is configured to be printed, the data on the number of times of hybridization by the method other than printing, such as engraving, using the biochemical analysis unit 171 thereof,
Data regarding the date and time when the hybridization was performed, as a labeling substance during hybridization,
When a radio-labeled substance is used, the radio-labeled data indicating that the radio-labeled substance was used and the data on the nuclide of the radio-labeled substance are displayed in the form of visible data in a large number of spot-shaped areas containing the specific binding substance. Adsorbent substrate 172 of biochemical analysis unit 171 in which 174 is formed
It may be recorded in.

Further, in the embodiment shown in FIGS. 1 to 17, the magnetic recording layer 5 is formed on the substrate 2 of the biochemical analysis unit 1, and the magnetic recording layer 5 has ID data and hybridization. Data regarding the execution date and time, data regarding whether or not a radioactive labeling substance was used as the labeling substance, data regarding the nuclide of the radioactive labeling substance, etc. are recorded, but an optical recording layer is provided instead of the magnetic recording layer 5. Then, ID data, data regarding the date and time of hybridization, data regarding whether or not a radiolabeled substance is used as a labeling substance, data regarding a nuclide of the radiolabeled substance, and the like may be recorded. It is also possible to provide a data recording layer capable of recording data by a recording method other than optical recording.

Further, in the embodiment shown in FIGS. 1 to 17, data on the number of times the biochemical analysis unit 1 was used for hybridization was formed on the substrate 2 of the biochemical analysis unit 1. 18 to 23, which is configured to magnetically record on the magnetic recording layer 5.
In the embodiment shown in FIG. 3, the biochemical analysis unit 171 is configured to print data on the number of times it has been used for hybridization on the absorptive substrate 172 of the biochemical analysis unit 171. The number of times the chemical analysis unit 1 has been used for hybridization is magnetically recorded in the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1, or the adsorption property of the biochemical analysis unit 171. It is not always necessary to print on the substrate 172, and the number of times the biochemical analysis units 1 and 171 have been used for hybridization may be detected by other means.

Further, in the embodiment shown in FIGS. 1 to 17, data on the number of times the biochemical analysis unit 1 was used for hybridization was formed on the substrate 2 of the biochemical analysis unit 1. Data is recorded magnetically on the magnetic recording layer 5, while in the embodiment shown in FIGS. 18 to 23, data relating to the number of times the biochemical analysis unit 1 has been used for hybridization,
The biochemical analysis units 1 and 171 are printed on the adsorptive substrate 172 of the biochemical analysis unit 171 and based on the data on the number of times used for hybridization.
However, when it is used for hybridization N times, the biochemical analysis units 1 and 171 are configured so that the hybridization cannot be performed. ,
It is not necessary to limit the number of times 171 can be used for hybridization.

Further, in the above embodiment, the biochemical analysis unit 1 is used as the cartridge 31 shown in FIG.
6 and FIG. 8 or the hybridization device 180 shown in FIG. 20 and FIG. 21, the absorptive region 4 of the biochemical analysis unit 1 or the biochemical analysis is stored. The specific binding substance contained in the spot-like region 174 of the unit 171 is selectively hybridized with a substance of biological origin labeled with a radioactive labeling substance and a substance of biological origin labeled with a fluorescent substance. However,
The biochemical analysis unit 1 is housed in the cartridge 31 shown in FIG. 7, and the hybridization apparatus 10 shown in FIGS. 6 and 8 or the hybridization apparatus 180 shown in FIGS. 20 and 21 is used. The specific binding substance contained in the adsorptive region 4 of the biochemical analysis unit 1 or the spot-like region 174 of the biochemical analysis unit 171 is changed by the substance derived from the living body and the fluorescent substance, which are labeled with the radioactive labeling substance. It is not always necessary to selectively hybridize the labeled substance derived from the living body, and the data regarding the date and time when the hybridization was carried out, and the radioactive labeling substance was used as the labeling substance during the hybridization. Sometimes, radiolabeled data indicating that a radiolabeled substance was used and As long as the data on the radionuclide of the radiolabeled substance can be recorded in the biochemical analysis units 1 and 171, any structure of the hybridization apparatus can be used to obtain the adsorptive region 4 of the biochemical analysis unit 1 or the biochemical analysis unit. The specific binding substance contained in the spot-like region 174 of the unit 171 for use is selectively hybridized with a substance of biological origin labeled with a radioactive labeling substance and a substance of biological origin labeled with a fluorescent substance. You may do it.

In the above-mentioned embodiment, the specific binding substance contained in the adsorptive region 4 of the biochemical analysis unit 1 or the spot-like region 174 of the biochemical analysis unit 171 is labeled with a radioactive labeling substance. The biogenic substance and the fluorescent substance are used to selectively hybridize the biogenic substance. Selectively hybridizing a specific binding substance contained in the spot-like region 174 of the unit 171 with a substance of biological origin labeled with a radioactive labeling substance and a substance of biological origin labeled with a fluorescent substance Is not always necessary, and the absorptive region 4 of the biochemical analysis unit 1 or the screen of the biochemical analysis unit 171 is not required. It is sufficient that at least a substance derived from a living body labeled with a radioactive labeling substance is selectively hybridized with a specific binding substance contained in the reticular region 174, and a substance derived from a living organism labeled with a fluorescent substance is used. In addition to the substance, or in place of the substance of biological origin labeled with a fluorescent substance, it is also possible to hybridize a substance of biological origin labeled with a labeling substance that causes chemiluminescence by contacting with a chemiluminescent substrate. Only the substance derived from the living body, which is capable of being labeled with the radioactive labeling substance, is adsorbed in the biochemical analysis unit 1 or the spot-shaped region 174 in the biochemical analysis unit 171.
It may be allowed to hybridize with the specific binding substance contained in.

Furthermore, in the embodiment shown in FIGS. 1 to 17, data on the date and time of execution of hybridization is formed on the substrate 2 of the biochemical analysis unit 1 each time hybridization is executed. Although it is configured to be recorded on the magnetic recording layer 5, each time the hybridization is performed, the hybridization of the hybridization recorded on the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 is performed. It can also be configured to overwrite the data regarding the execution date and time.

Further, in the embodiment shown in FIGS. 1 to 17, data on the execution date and time of hybridization is formed on the substrate 2 of the biochemical analysis unit 1 every time hybridization is executed. In the embodiment shown in FIGS. 18 to 23, which is configured to be recorded on the magnetic recording layer 5, the data regarding the execution date and time of the hybridization is recorded every time the hybridization is executed. 1
71 is configured to be printed on the absorptive substrate 172, but each time hybridization is performed,
Data relating to the date on which the hybridization was performed is recorded on the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1, or printed on the absorptive substrate 172 of the biochemical analysis unit 171. The biochemical analysis units 1 and 171 may be configured to be managed according to the date when the hybridization is performed.

Further, in the embodiment shown in FIGS. 1 to 17, prior to the hybridization, the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 by the hybridization device 10 is Data on the date and time of hybridization, when a radiolabeled substance was used as a labeling substance during hybridization, radiolabeled data indicating that the radiolabeled substance was used and data on the nuclide of the radiolabeled substance. In the embodiment recorded and shown in FIGS. 18-23, prior to the hybridization, the hybridization device 10
On the adsorptive substrate 172 of the biochemical analysis unit 171, data relating to the date and time when the hybridization was carried out, as a labeling substance at the time of the hybridization,
When the radiolabeled substance is used, the radiolabeled data indicating that the radiolabeled substance was used and the data on the nuclide of the radiolabeled substance are printed. The data relating to the date and time of hybridization, the radiolabeling data and the data relating to the nuclide of the radiolabeled substance are recorded on the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 by the unit 10. 171 absorptive substrate 172
In addition, you may make it print the data regarding the date and time when the hybridization was performed, the radiolabeled data, and the data regarding the nuclide of the radiolabeled substance.

Further, in the embodiment shown in FIGS. 24 to 26, the stimulable phosphor contained in the stimulable phosphor layer region 72 of the stimulable phosphor sheet 70 is exposed by using the exposure device. Is exposed to the radioactive labeling substance contained in the adsorptive region 4 of the biochemical analysis unit 1, and the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 is exposed. Data about the date and time
The radiolabeling data and the data relating to the nuclide of the radiolabeling substance are recorded, but in the exposure process, the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1,
If the data regarding the date and time when the exposure operation is performed, the radiolabeled data, and the data regarding the nuclide of the radiolabeled substance can be recorded, the stimulable phosphor sheet 70 is formed by using the exposure apparatus having the configuration shown in FIGS. It is not always necessary to expose the stimulable phosphor contained in the region 72 of the stimulable phosphor layer with the radioactive labeling substance contained in the adsorptive region 4 of the biochemical analysis unit 1. The stimulable phosphor contained in the stimulable phosphor layer area 72 of the stimulable phosphor sheet 70 can be removed from the stimulable area 4 of the biochemical analysis unit 1 by using an exposure apparatus having any configuration.
You may make it expose by the radioactive labeling substance contained in.

Further, in the embodiment shown in FIGS. 24 to 26, the magnetic recording head 212 of the exposure apparatus is used to expose the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1. Data relating to the date and time when the operation is carried out, radioactive labeling data, and data relating to the nuclide of the radioactive labeling substance are recorded. Instead of the magnetic recording head 212, an exposure apparatus equipped with an optical recording head is used and shown in FIG. 18 in place of the biochemical analysis unit 1 that has been prepared.
The stimulable phosphor layer region 72 of the stimulable phosphor sheet 70 is exposed by the biochemical analysis unit 171 shown in FIG.
The data on the date and time when the exposure operation is performed, the radiolabeled data and the data on the nuclide of the radiolabeled substance are printed on 72, and the biochemical analysis unit sorter shown in FIG. 22 and FIG. The analysis unit 171 may be selected and collected.

In the embodiment shown in FIGS. 24 to 26, prior to the exposure operation, the exposure apparatus exposes the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 to the exposure operation. Data about the date and time to execute,
The radiolabeling data and the data relating to the nuclide of the radiolabeled substance are recorded, but after the exposure operation, the substrate 2 of the biochemical analysis unit 1 is exposed by the exposure device.
The magnetic recording layer 5 formed on the disk may be configured to record data relating to the date and time when the exposure operation is performed, radiolabeling data and data relating to the nuclide of the radiolabeled substance.

Further, in the embodiment shown in FIG. 1 to FIG. 17, the date and time of execution of hybridization on the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 by the hybridization device 10 is related. When a radiolabeled substance is used as the labeling substance during data and hybridization, the radiolabeled data indicating that the radiolabeled substance was used and the data on the radionuclide nuclide are recorded, and FIG.
6 and the biochemical analysis unit selection device shown in FIG. 17, the data regarding the execution date and time of the hybridization recorded in the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1, the radioactive labeling data, and The biochemical analysis unit 1 is selected and collected according to the data on the radiolabeled nuclide, and in the embodiment shown in FIGS. 18 to 23, the biochemical analysis unit 1 is used for the biochemical analysis. Data relating to the date and time when the hybridization was performed on the absorptive substrate 172 of the unit 171, and when a radioactive labeling substance was used as the labeling substance during the hybridization, a radioactivity indicating that the radioactive labeling substance was used. Printing of labeling data and radionuclide data 22 and 23, the data relating to the execution date and time of hybridization printed on the absorptive substrate 172 of the biochemical analysis unit 171 by the biochemical analysis unit selection device, the radioactive labeling data and the radioactive labeling substance. The biochemical analysis unit 171 is selected according to the nuclide data of
Although it is configured to be collected, the date on which the radiolabeled substance is generated or the data on the date and time when the radiolabeled substance is generated is replaced by the keyboard 60 of the hybridization device 10 in place of the data on the date and time of hybridization. To the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1,
With the biochemical analysis unit selection device shown in FIGS. 16 and 17, the date or radioactivity at which the radiolabeled substance recorded in the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 was produced. The biochemical analysis unit 1 is selected and collected according to the data on the date and time when the labeled substance was generated, the radiolabeled data, and the data on the radionuclide of the radiolabeled substance. Data regarding the date when the labeling substance was generated or the date when the radioactive labeling substance was generated was input to the keyboard 60 of the hybridization apparatus 10 and printed on the absorptive substrate 172 of the biochemical analysis unit 171, and as shown in FIG. With the biochemical analysis unit selection device shown in FIG. 23, the biochemical analysis unit is selected. For the biochemical analysis according to the date on which the radiolabeled substance was printed on the adsorptive substrate 172 of the unit 171 or the date and time on which the radiolabeled substance was produced, the radiolabeled data and the data on the nuclide of the radiolabeled substance. The unit 171 may be sorted and collected.

Further, in the embodiment shown in FIGS. 24 to 26, the date and time when the exposure operation is performed on the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1 by the exposure apparatus will be described. The data, the radiolabeling data and the data relating to the radionuclide nuclide are recorded, and the substrate 2 of the biochemical analysis unit 1 is processed by the biochemical analysis unit selection device shown in FIGS. 16 and 17.
The biochemical analysis unit 1 is selected and collected according to the data regarding the date and time when the exposure operation is performed recorded on the magnetic recording layer 5 formed on the substrate, the radiolabel data and the data regarding the nuclide of the radiolabel substance. However, instead of the data regarding the date and time of execution of hybridization or the data regarding the date and time of execution of the exposure operation, the data regarding the date on which the radiolabeled substance was generated or the date regarding the date and time on which the radiolabeled substance was generated was used. Is input to the keyboard 215 of the biochemical analysis unit 1, recorded on the magnetic recording layer 5 formed on the substrate 2 of the biochemical analysis unit 1, and biochemically analyzed by the biochemical analysis unit selection device shown in FIGS. 16 and 17. Board 2 of unit 1
For the biochemical analysis according to the date on which the radiolabeled substance was recorded or the date and time on which the radiolabeled substance was recorded, recorded on the magnetic recording layer 5 formed on the magnetic recording layer 5, the radiolabeled data and the data on the radionuclide nuclide. The unit 1 may be sorted and collected.

Furthermore, in the embodiment shown in FIGS. 1 to 17, the substrate 2 of the biochemical analysis unit 1 is
The approximately circular adsorptive regions 4 having a size of about 0.01 mm 2 of about 10,000 were formed according to a regular pattern with a density of about 5000 pieces / cm 2, and were shown in FIGS. 18 to 23. In an embodiment, the absorptive substrate 172 of the biochemical analysis unit 171 has approximately 10,000 spots 174 of approximately circular shape having a size of about 0.01 square millimeter, and a regular density of about 5000 spots / square centimeter. Although it is formed according to a general pattern, the absorptive region 4 and the spot-shaped region 174 do not necessarily need to be formed in a substantially circular shape, and can be formed in any shape such as a rectangular shape.

Also, in the embodiment shown in FIGS. 1 to 17, the substrate 2 of the biochemical analysis unit 1 is
The approximately circular adsorptive regions 4 having a size of about 0.01 mm 2 of about 10,000 were formed according to a regular pattern with a density of about 5000 pieces / cm 2, and were shown in FIGS. 18 to 23. In an embodiment, the absorptive substrate 172 of the biochemical analysis unit 171 has approximately 10,000 spots 174 of approximately circular shape having a size of about 0.01 square millimeter, and a regular density of about 5000 spots / square centimeter. Is formed according to a general pattern, but the absorptive region 4 is formed.
Alternatively, the number and size of the spot-like regions 174 can be arbitrarily selected according to the purpose, and preferably, the absorptive region 4 or the spot-like regions 174 having a size of 10 or more and less than 5 mm 2 is 10
It is formed on the substrate 2 or the absorptive substrate 172 with a density of at least one piece / square centimeter.

Further, in the embodiment shown in FIGS. 1 to 17, the substrate 2 of the biochemical analysis unit 1 is
The approximately circular adsorptive regions 4 having a size of about 0.01 mm 2 of about 10,000 were formed according to a regular pattern with a density of about 5000 pieces / cm 2, and were shown in FIGS. 18 to 23. In an embodiment, the absorptive substrate 172 of the biochemical analysis unit 171 has approximately 10,000 spots 174 of approximately circular shape having a size of about 0.01 square millimeter, and a regular density of about 5000 spots / square centimeter. Is formed according to a general pattern, but the absorptive region 4 is formed.
Alternatively, it is not always necessary to form the spot-shaped regions 174 according to a regular pattern.

Further, in the embodiment shown in FIGS. 1 to 17, the biochemical analysis unit 1 is filled with nylon 6 inside a large number of through holes 3 formed in a substrate 2 made of aluminum. The formed absorptive regions 4
In the embodiment shown in FIGS. 18 to 23, the biochemical analysis unit 171 includes the adsorptive substrate 172 formed of nylon 6, but the biochemical analysis unit 1 has the adsorptive property. It is not always necessary that the region 4 or the absorptive substrate 172 of the biochemical analysis unit 171 is made of nylon 6, and a porous material other than nylon 6 capable of forming a membrane filter, for example, nylon 6,6. , Nylons such as nylon 4,10; cellulose derivatives such as nitrocellulose, cellulose acetate, cellulose acetate butyrate; collagen; alginic acid, calcium alginate, alginic acid /
Alginic acids such as polylysine polyion complex; polyolefins such as polyethylene and polypropylene; polyvinyl chloride; polyvinylidene chloride; polyfluoride such as polyvinylidene fluoride and polytetrafluoride; and copolymers or composites thereof, or The absorptive region 4 of the biochemical analysis unit 1 or the absorptive substrate 172 of the biochemical analysis unit 171 can be formed of a porous carbon material such as activated carbon.
Furthermore, metals such as platinum, gold, iron, silver, nickel and aluminum; metal oxides such as alumina, silica, titania and zeolite; metal salts such as hydroxyapatite and calcium sulfate and inorganic porous materials such as composites thereof. The absorptive region 4 of the biochemical analysis unit 1 or the biochemical analysis unit 1 depends on a material or a bundle of a plurality of fibers.
The absorptive substrate 172 of 71 may be formed.

Furthermore, in the embodiment shown in FIGS. 1 to 17, the biochemical analysis unit 1 is provided with a substrate 2 made of aluminum. It is not always necessary to form the substrate 2, but the substrate 2 can be formed of other materials. The material for forming the substrate 2 of the biochemical analysis unit 1 preferably has a property of attenuating radiation, but is not particularly limited and may be an inorganic compound material or an organic compound material. The substrate 2 of the biochemical analysis unit 1 can also be formed, and a metal material, a ceramic material, or a plastic material is preferably used, and a metal material is particularly preferable from the viewpoint of having high radiation attenuation ability. used. Examples of metal materials that can be preferably used to form the substrate 2 of the biochemical analysis unit 1 include, for example, gold, silver, copper, zinc, aluminum, titanium, tantalum, chromium, iron, nickel, cobalt, and lead. , Metals such as tin and selenium; alloys such as brass, stainless steel and bronze. Examples of inorganic compound materials other than metal materials include silicon materials such as silicon, amorphous silicon, glass, quartz, silicon carbide and silicon nitride. Metal oxides such as aluminum oxide, magnesium oxide and zirconium oxide; inorganic salts such as tungsten carbide, calcium carbonate, calcium sulfate, hydroxyapatite and gallium arsenide. These may have any structure in a polycrystalline sintered body such as single crystal, amorphous, or ceramic. Further, as the organic compound material that can be used to form the substrate 2 of the biochemical analysis unit 1, a high molecular compound is preferably used, and a preferable high molecular compound is, for example, a polyolefin such as polyethylene or polypropylene. ; Polymethyl methacrylate, butyl acrylate /
Acrylic resins such as methylmethacrylate copolymers; polyacrylonitrile; polyvinyl chloride; polyvinylidene chloride; polyvinylidene fluoride; polytetrafluoroethylene; polychlorotrifluoroethylene; polycarbonate; polyesters such as polyethylene naphthalate and polyethylene terephthalate; nylon 6 Polyamide; Polysulfone; Polyphenylene sulfide; Silicon resin such as polydiphenylsiloxane; Phenolic resin such as novolac; Epoxy resin; Polyurethane; Polystyrene; Butadiene-styrene copolymer; Cellulose Polysaccharides such as cellulose acetate, nitrocellulose, starch, calcium alginate, hydroxypropylmethylcellulose; ; Chitosan; lacquer; gelatin, collagen, copolymers of polyamides and these high molecular compounds, such as keratin, and the like.
These may be a composite material, if necessary, can be filled with metal oxide particles or glass fiber,
It is also possible to blend and use an organic compound material.

In the embodiment shown in FIGS. 1 to 17, the plurality of absorptive regions 4 of the biochemical analysis unit 1 are arranged inside the plurality of through holes 3 formed in the aluminum substrate 2. Nylon 6 is filled in and formed, but an adsorptive film containing an adsorptive material is press-fitted into a large number of through holes 3 formed in the substrate 2, and a large number of biochemical analysis units 1 are formed. It is also possible to form the absorptive region 4 of.

Further, in the embodiment shown in FIGS. 1 to 17, the large number of absorptive regions 4 of the biochemical analysis unit 1 are arranged inside the large number of through holes 3 formed in the aluminum substrate 2. A substrate in which a plurality of through holes are formed on at least one surface of an absorptive substrate formed of an absorptive material, which is formed by being filled with nylon 6 It is also possible to form a plurality of absorptive regions separated from each other by closely adhering to each other and the absorptive substrates in the plurality of through holes.

[0464]

INDUSTRIAL APPLICABILITY According to the present invention, a bio-derived substance labeled with a radio-labeled substance is hybridized with a specific binding substance, and the biochemical analysis unit used for biochemical analysis is It becomes possible to provide a management method and a management system for a biochemical analysis unit, which can be managed reliably until the level is attenuated below a predetermined level.

[Brief description of drawings]

FIG. 1 is a schematic perspective view of a biochemical analysis unit managed by a biochemical analysis unit management system according to a preferred embodiment of the present invention.

FIG. 2 is a schematic front view of a spotting device.

FIG. 3 is a schematic side view of a hybridization apparatus that constitutes a biochemical analysis unit management system according to a preferred embodiment of the present invention.

FIG. 4 is a schematic perspective view of a cartridge.

FIG. 5 is a block diagram of a control system, a detection system, a drive system, an input system, and a display system of a hybridization device which constitutes a management system for a biochemical analysis unit according to a preferred embodiment of the present invention. .

FIG. 6 is a schematic perspective view of a stimulable phosphor sheet.

FIG. 7 shows a large number of stimulable phosphor layer regions formed on a stimulable phosphor sheet by a radiolabel substance contained in a large number of adsorptive regions formed in a biochemical analysis unit. It is a schematic sectional drawing which shows the method of exposing.

FIG. 8 is a diagram showing the radiation data recorded on the stimulable phosphor sheet to generate biochemical analysis data and the fluorescence data recorded on the biochemical analysis unit to read the biochemical analysis data. 3 is a schematic perspective view of a scanner that generates analysis data. FIG.

9 is a schematic perspective view showing details near the photomultiplier of the scanner shown in FIG. 8;

10 is a schematic cross-sectional view taken along the line AA of FIG.

11 is a schematic cross-sectional view taken along the line BB of FIG.

FIG. 12 is a schematic cross-sectional view taken along the line CC of FIG.

FIG. 13 is a schematic cross-sectional view taken along the line DD of FIG.

FIG. 14 is a schematic plan view of a scanning mechanism of an optical head.

15 is a block diagram showing a control system, an input system, a drive system and a detection system of the scanner shown in FIG.

FIG. 16 is a schematic plan view of a biochemical analysis unit selection device that constitutes a biochemical analysis unit management system according to a preferred embodiment of the present invention.

FIG. 17 is a block diagram showing a control system, a detection system, a drive system, and an input system of a biochemical analysis unit selection device that constitutes a biochemical analysis unit management system according to a preferred embodiment of the present invention. Is.

FIG. 18 is a schematic perspective view of a biochemical analysis unit managed by a biochemical analysis unit management system according to another preferred embodiment of the present invention.

FIG. 19 is a diagram for biochemical analysis in which a solution containing a specific binding substance is dropped onto a adsorptive substrate of a biochemical analysis unit by a spotting device to form a plurality of spot-shaped regions separated from each other. It is a schematic perspective view of a unit.

FIG. 20 is a schematic side view of a hybridization device that constitutes a management system for a biochemical analysis unit according to another preferred embodiment of the present invention.

FIG. 21 is a block diagram of a control system, a detection system, a drive system, an input system and a display system of a hybridization device which constitutes a management system of a biochemical analysis unit according to another preferred embodiment of the present invention. Is.

FIG. 22 is a schematic plan view of a biochemical analysis unit selection device that constitutes a biochemical analysis unit management system according to another preferred embodiment of the present invention.

FIG. 23 shows a control system, a detection system, a drive system and an input system of a biochemical analysis unit selection device which constitutes a biochemical analysis unit management system according to another preferred embodiment of the present invention. It is a block diagram.

FIG. 24 is a diagram showing the stimulable phosphor contained in the stimulable phosphor layer region formed on the stimulable phosphor sheet shown in FIG. The radioactive labeling substance selectively contained in the adsorptive region
It is a schematic perspective view of the exposure apparatus which exposes.

FIG. 25 is a schematic partial cross-sectional view showing a mechanism for locking the lid member of the stimulable phosphor sheet exposure apparatus to the casing.

FIG. 26 is a block diagram showing a control system, a detection system, a drive system, a display system and an input system of the exposure apparatus for the stimulable phosphor sheet.

[Explanation of symbols]

1 Biochemical Analysis Unit 2 Substrate 3 Through Hole 4 Adsorbent Area 5 Magnetic Recording Layer 7 Injector 8 CCD Camera 9 Spotting Head 10 Hybridization Device 11 Cartridge 11a Cartridge 11b Cartridge Lid 11c Solution Injection / Extraction Port 12 Cartridge Loading Part 13 Solution injecting part 14 Reaction part 15 Biochemical analysis unit take-out part 16a First endless belt 16b, 16c Pulley 17 Read head 18 Magnetic recording head 19 Loading mechanism 20a Second endless belt 20b, 20c Pulley 21a Third Endless belts 21b and 21c Pulley 22 Pretreatment liquid injection pin 23 Hybridization solution injection pin 24 Probe solution injection pin 25 Cleaning solution injection pin 26 Solution pin head 27a Fourth end Belt 27b, 27c Pulley 28 Vibration table 29a Fifth endless belt 29b, 29c Pulley 30 Radiation sensor 31 Solution extraction pin 32 Biochemical analysis unit removal mechanism 40 Control unit 41 First motor 42 Second motor 43 Third Motor 44 Fourth Motor 45 Fifth Motor 46 Vibration Table Motor 47 Injection Pin Motor 48 Radiation Sensor Motor 49 Solution Extraction Pin Motor 50 Pretreatment Liquid Pump 51 Hybridization Solution Pump 52 Probe Solution Pump 53 Cleaning Solution Pump 54 Solution Extraction Pump 55 Valve Opening / closing mechanism 60 Keyboard 61 Display panel 70 Accumulable phosphor sheet 71 Support 72 Photostimulable phosphor layer region 73 Through hole 81 First laser excitation light source 82 Second laser excitation light source 83 Third laser Excitation light source 84 Laser light 85 Collimator lens 86 Mirror 87 First dichroic mirror 88 Second dichroic mirror 89 Mirror 90 Collimator lens 91 Collimator lens 92 Mirror 93 Perforated mirror hole 94 Perforated mirror 95 Optical head 96 Mirror 97 Aspherical surface Lens 98 Concave mirror 100 Stage 101 Glass plate 105 Fluorescence or photostimulable light 108 Filter unit 110 Photomultipliers 111a, 111b, 111c, 111d Filter members 112a, 112b, 112c, 112d Filter 113 A / D converter 114 Data processing device 120 Substrate 121 Sub-scanning pulse motor 122 Pair of rails 123 Movable substrate 124 Rod 125 Main-scanning stepping motor 126 Endless belt 127 Linear encoder Encoder 128 linear encoder slit 130 control unit 131 keyboard 132 filter unit motor 140 endless belt 141 reading head 142 biochemical analysis unit loading box 144a first chute 144b second chute 144n nth chute 145a, 145b, 145n raw Chemical analysis unit Recovery box 147 Disposal box 148a First sorting member 148b Second sorting member 148n nth sorting member 150a First solenoid 150b Second solenoid 150n nth solenoid 160 Control unit 161 Endless belt motor 162 Biochemical analysis unit sending mechanism 163 Keyboard 171 Biochemical analysis unit 172 Adsorbent substrate 174 Spot-shaped area 180 Hybridization device 187 Optical reading head 188 Printing head 191 Optical reading head 200 Casing 201 Cover member 202 Substrate 203 Data reading / recording parts 204a and 204b Positioning pin 205 Hook member 205a Hook member shaft 206 Compression spring 207 Engagement groove 208 Solenoid 210 Control unit 211 Reading head 212 Magnetic recording head 213 Display panel 214 Lid member release button 215 Keyboard

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) G21K 4/00 G21K 4/00 N (72) Inventor Toru Tsuchiya 798, Miyadai, Kaisei-cho, Ashigarakami-gun, Kanagawa Photo: F-term in Film Co., Ltd. (reference) 2G045 DA13 DA14 FA12 FA19 FA29 FB02 FB08 FB12 GC15 JA04 2G054 AA10 AB10 BB07 CA22 EA03 EB01 GA04 GA05 GE01 JA04 2G083 AA03 AA09 BB03 BB10 CC03 CC04 CC10

Claims (39)

[Claims] 1. A method for managing a biochemical analysis unit in which a plurality of absorptive regions containing a specific binding substance having a known structure or property are separated from each other, the biochemical analysis unit comprising: When performing a biochemical analysis using, management data including data relating to a time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance is recorded in the biochemical analysis unit. Management method for biochemical analysis unit. 2. The specific binding substance contained in the plurality of absorptive regions of the biochemical analysis unit is selectively replaced with a substance of biological origin labeled with a radioactive labeling substance by a hybridization device, When hybridizing, by the hybridization device,
2. The biochemical analysis unit according to claim 1, wherein management data including data relating to time used as a reference for calculating a decay time of radiation contained in the radiolabeled substance is recorded in the biochemical analysis unit. How to manage units. 3. Data relating to a time serving as a reference for calculating a decay time of radiation contained in the radiolabeled substance,
The method for managing a biochemical analysis unit according to claim 2, wherein the management data includes data regarding the date and time when the hybridization is performed. 4. Data relating to time, which is a reference for calculating the decay time of radiation contained in the radiolabeled substance,
The method for managing a unit for biochemical analysis according to claim 2, characterized in that the method includes data regarding a date on which hybridization is performed. 5. A biologically-derived substance labeled with a radioactive labeling substance by a hybridization device is selectively added to a specific binding substance contained in the plurality of adsorptive regions of the biochemical analysis unit, After hybridizing, using the exposure device, the biochemical analysis unit is superposed on the stimulable phosphor sheet having the stimulable phosphor layer containing the stimulable phosphor, and the biochemical analysis is performed. Regarding the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance by the exposure device when exposing with the radiolabeled substance selectively contained in the plurality of absorptive regions of the analysis unit The management method of the biochemical analysis unit according to claim 1, wherein management data including data is recorded in the biochemical analysis unit. 6. Data relating to a time serving as a reference for calculating a decay time of radiation contained in the radiolabeled substance,
The method for managing a biochemical analysis unit according to claim 5, wherein the method includes data relating to the date and time when the exposure operation is executed. 7. Data relating to a time serving as a reference for calculating a decay time of radiation contained in the radiolabeled substance,
The method for managing a biochemical analysis unit according to claim 5, further comprising data regarding a date on which the exposure operation is performed. 8. Data relating to time as a reference for calculating a decay time of radiation contained in the radiolabeled substance,
8. The biochemical analysis unit management method according to claim 1, further comprising data relating to the date and time when the radiolabeled substance was generated. 9. Data relating to a time serving as a reference for calculating a decay time of radiation contained in the radiolabeled substance,
8. The method for managing the biochemical analysis unit according to claim 1, further comprising data relating to the date when the radiolabeled substance was produced. 10. The biochemical analysis unit includes a substrate in which a plurality of holes are formed apart from each other, and the plurality of absorptive regions are provided in the plurality of holes formed in the substrate. The management data is recorded on the substrate of the biochemical analysis unit, which is formed by filling the adsorptive material with the adsorptive material filled in the plurality of holes and containing the specific binding substance. The method for managing a biochemical analysis unit according to any one of claims 1 to 9, characterized in that. 11. The biochemical analysis unit includes an absorptive substrate formed of an absorptive material, and at least one surface of the absorptive substrate has a property of attenuating radiation and has a plurality of through holes. The substrate on which the
A plurality of absorptive regions are formed by the absorptive substrate in the plurality of through holes formed in the substrate, and the management data is recorded on the substrate of the biochemical analysis unit. The method for managing the biochemical analysis unit according to claim 1. 12. The method for managing a biochemical analysis unit according to claim 10, wherein the management data is recorded as visible data on the substrate of the biochemical analysis unit. 13. The raw material according to claim 10, wherein a magnetic recording layer is formed on the substrate of the biochemical analysis unit, and the management data is magnetically recorded on the magnetic recording layer. Management method of chemical analysis unit. 14. The biochemical analysis unit management method according to claim 10, wherein the substrate of the biochemical analysis unit has a property of attenuating radiation. 15. When the radiation of the substrate of the biochemical analysis unit is transmitted through the substrate by a distance equal to the distance between the adjacent absorptive regions, the energy of the radiation is reduced to 1/5. 15. The method for managing a biochemical analysis unit according to claim 14, characterized in that it has the following attenuation property. 16. The method for managing a biochemical analysis unit according to claim 10, wherein 10 or more absorptive regions are formed on the substrate of the biochemical analysis unit. 17. The absorptive region formed on the substrate of the biochemical analysis unit has a size of less than 5 square millimeters, respectively. Management method of the described biochemical analysis unit. 18. The one of claim 10 to 17, wherein the plurality of absorptive regions are formed on the substrate of the biochemical analysis unit at a density of 10 or more per cm 2. The method for managing the biochemical analysis unit according to item 1. 19. The biochemical analysis unit includes an absorptive substrate formed of an absorptive material, and the plurality of absorptive regions are specific binding substances whose structures or characteristics are known to the absorptive substrate. Is formed by dripping a solution containing
10. The management data is recorded on the absorptive substrate of the biochemical analysis unit.
The method for managing the biochemical analysis unit according to any one of 1. 20. The biochemical analysis unit management method according to claim 19, wherein the management data is recorded as visible data on the absorptive substrate of the biochemical analysis unit. 21. The management data includes data on a nuclide of the radiolabeled substance in addition to data on a time serving as a reference for calculating a decay time of radiation contained in the radiolabeled substance. Claim 1
21. A method for managing a biochemical analysis unit according to any one of 1 to 20. 22. The disposal time of the biochemical analysis unit is determined on the basis of data on a time serving as a reference for calculating a decay time of radiation contained in the radiolabeled substance and data on a nuclide of the radiolabeled substance. The method for managing a biochemical analysis unit according to claim 21, wherein the biochemical analysis unit is selected and managed according to the disposal time. 23. A system for managing a unit for biochemical analysis, wherein a plurality of absorptive regions containing a specific binding substance having a known structure or characteristic are separated from each other,
For biochemical analysis, characterized by comprising a management data recording device for recording management data including data relating to time as a reference for calculating the decay time of radiation contained in the radiolabeled substance in the biochemical analysis unit. Unit management system. 24. Further, a specific binding substance contained in the plurality of absorptive regions of the biochemical analysis unit is selectively hybridized with a substance of biological origin labeled with a radioactive labeling substance. 3. A hybridization device is provided, and the hybridization device is provided with the management data recording device.
3. The management system for the biochemical analysis unit according to 3. 25. The raw material according to claim 24, wherein the data on the time serving as a reference for calculating the decay time of the radiation contained in the radio-labeled substance includes data on the date and time when the hybridization is performed. Management system for chemical analysis unit. 26. The raw material according to claim 24, wherein the data on the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes the data on the day on which the hybridization is carried out. Management system for chemical analysis unit. 27. A plurality of specific binding substances having a known structure or property and a plurality of substances labeled with at least a radioactive labeling substance and containing a substance derived from a living body which is selectively hybridized with the specific binding substance. The biochemical analysis unit in which the absorptive region is formed is provided with a support, and the support is superposed on the stimulable phosphor sheet on which the stimulable phosphor layer containing the stimulable phosphor is formed. The exposure unit for exposing the stimulable phosphor layer of the stimulable phosphor sheet by a radioactive labeling substance selectively contained in the plurality of absorptive regions of the biochemical analysis unit, 24. The biochemical analysis unit management system according to claim 23, wherein the device comprises the management data recording device. 28. The raw material according to claim 27, wherein the data regarding the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes data regarding the date and time when the exposure operation is executed. Management system for chemical analysis unit. 29. The raw material according to claim 27, wherein the data regarding the time serving as a reference for calculating the decay time of the radiation contained in the radio-labeled substance includes data regarding the date on which the exposure operation is performed. Management system for chemical analysis unit. 30. The data relating to the time serving as a reference for calculating the decay time of radiation contained in the radio-labeled substance includes data relating to the date and time when the radio-labeled substance was produced. Or 1
The management system for the biochemical analysis unit according to the item. 31. The data according to any one of claims 23 to 29, wherein the data on the time serving as a reference for calculating the decay time of the radiation contained in the radiolabeled substance includes the data on the date when the radiolabeled substance was produced. The method for managing the biochemical analysis unit according to item 1. 32. The biochemical analysis unit comprises a substrate in which a plurality of holes are formed apart from each other, and the plurality of absorptive regions are provided in the plurality of holes formed in the substrate, An adsorbent material filled with the adsorbent material filled in the plurality of pores is formed by containing the specific binding substance, and the management data recording device is provided on the substrate of the biochemical analysis unit. 32. The biochemical analysis unit management system according to claim 23, wherein the management data is recorded. 33. The biochemical analysis unit comprises an absorptive substrate formed of an absorptive material, and at least one surface of the absorptive substrate has a property of attenuating radiation and has a plurality of through holes. The substrate on which the
A plurality of absorptive regions are formed by the absorptive substrate in the plurality of through holes formed on the substrate, and the management data recording device stores the management data on the substrate of the biochemical analysis unit. 32. The biochemical analysis unit management system according to claim 23, which is configured to record. 34. The management data recording device is configured to record the management data as visible data on the substrate of the biochemical analysis unit. Management system for the biochemical analysis unit described. 35. A magnetic recording layer is formed on the substrate of the biochemical analysis unit, and the management data recording device is configured to magnetically record the management data on the magnetic recording layer. 34. The biochemical analysis unit management system according to claim 32 or 33. 36. The biochemical analysis unit comprises an absorptive substrate formed of an absorptive material, and the plurality of absorptive regions are specific binding substances whose structures or characteristics are known to the absorptive substrate. Is formed by dripping a solution containing
32. The raw material according to claim 23, wherein the management data recording device is configured to record the management data on the absorptive substrate of the biochemical analysis unit. Management system for chemical analysis unit. 37. The management data recording device is configured to record the management data as visible data on the absorptive substrate of the biochemical analysis unit. Management system for the biochemical analysis unit described. 38. The management data includes data on a nuclide of the radiolabeled substance, in addition to data on a time serving as a reference for calculating a decay time of radiation contained in the radiolabeled substance. Claim 2
38. A biochemical analysis unit management system according to any one of 3 to 37. 39. Further, based on the data on the time serving as a reference for calculating the decay time of radiation contained in the radiolabeled substance and the data on the nuclide of the radiolabeled substance, the disposal time of the biochemical analysis unit is determined. 4. A biochemical analysis unit selection device configured to determine and manage the biochemical analysis unit according to the determined time and the disposal time.
8. A management system for the biochemical analysis unit according to 8.