JP2003104920A - Dihydronaphthalene derivative, liquid crystal composition containing the same and liquid crystal display element - Google Patents

Dihydronaphthalene derivative, liquid crystal composition containing the same and liquid crystal display element

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Publication number
JP2003104920A
JP2003104920A JP2001301171A JP2001301171A JP2003104920A JP 2003104920 A JP2003104920 A JP 2003104920A JP 2001301171 A JP2001301171 A JP 2001301171A JP 2001301171 A JP2001301171 A JP 2001301171A JP 2003104920 A JP2003104920 A JP 2003104920A
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JP
Japan
Prior art keywords
dihydronaphthalene
trans
group
difluoro
general formula
Prior art date
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JP2001301171A
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Japanese (ja)
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JP4844785B2 (en
Inventor
Yoshitaka Saito
佳孝 斉藤
Tetsuo Kusumoto
哲生 楠本
Sadao Takehara
貞夫 竹原
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DIC Corp
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Dainippon Ink and Chemicals Co Ltd
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Priority to JP2001301171A priority Critical patent/JP4844785B2/en
Publication of JP2003104920A publication Critical patent/JP2003104920A/en
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  • Liquid Crystal Substances (AREA)

Abstract

PROBLEM TO BE SOLVED: To provide a liquid crystal compound having an improved liquid crystal temperature range, improving compatibility with other liquid crystal materials or without depraving the compatibility and effectively decreasing the response and threshold voltage, to provide a practical liquid crystal composition using the compound, and to provide a liquid crystal display element using the compound. SOLUTION: This compound is represented by the general formula (1), the liquid crystal composition containing the compound is provided and the liquid crystal display element is also provided. The liquid crystal compound is an excellent material for a high speed liquid crystal display and has effect for decreasing the threshold voltage and so has large effect for electric power saving for the liquid crystal display.

Description

【発明の詳細な説明】Detailed Description of the Invention

【０００１】[0001]

【従来の技術】液晶表示素子は、時計、電卓をはじめと
して、各種測定機器、携帯電話、自動車用パネル、ワー
プロ、電子手帳、プリンター、コンピューター、テレビ
等に用いられるようになっている。液晶表示方式として
は、その代表的なものにTN(捩れネマチック)型、STN(超
捩れネマチック)型、DS(動的光散乱)型、GH(ゲスト・ホ
スト)型あるいは高速応答が可能なFLC(強誘電性液晶)等
を挙げることができる。また駆動方式としても従来のス
タティック駆動からマルチプレックス駆動が一般的にな
り、最近ではAM-LCD(アクティブマトリックス)方式が実
用化されている。2. Description of the Related Art Liquid crystal display devices have come to be used in watches, calculators, various measuring instruments, mobile phones, automobile panels, word processors, electronic notebooks, printers, computers, televisions and the like. Typical liquid crystal display systems are TN (twisted nematic) type, STN (super twisted nematic) type, DS (dynamic light scattering) type, GH (guest host) type, or FLC capable of high-speed response. (Ferroelectric liquid crystal) and the like. Also, as the drive system, the conventional static drive has become more common and multiplex drive has become popular, and recently the AM-LCD (active matrix) system has been put into practical use.

【０００２】近年携帯を目的としたノート型コンピュー
ターの需要が高まり、屋外での使用を可能とする広い使
用温度範囲や長時間のバッテリー駆動を可能とする低消
費電力の要請が強まり、電力需要の逼迫及び省資源化の
要求から屋内で用いられる機器ですら消費電力の削減が
強く望まれている。低消費電力には低電圧で駆動できる
閾値電圧の低い液晶組成物が求められている。しきい値
電圧を低くするためには、誘電率異方性(Δε)を大きく
する材料が必要であるが、誘電率異方性が大きい材料は
一般に粘性が増大しレスポンスが悪化し易いという問題
があった。In recent years, the demand for portable notebook computers has increased, and there has been an increasing demand for low power consumption that enables a wide operating temperature range that enables outdoor use and long-term battery drive. Due to the demand for tightness and resource saving, it is strongly desired to reduce the power consumption even for the equipment used indoors. A liquid crystal composition having a low threshold voltage that can be driven at a low voltage is required for low power consumption. To lower the threshold voltage, a material that increases the dielectric anisotropy (Δε) is required, but a material with a large dielectric anisotropy generally has a problem of increased viscosity and poor response. was there.

【０００３】このため、TN、STN、AM-LCD等の液晶表示
素子用液晶組成物には、 (1) 屋外でも使用できる広い液晶相温度範囲 (2) 低い閾値電圧 (3) 早いレスポンス (4) 他の液晶材料との相溶性 が求められていおり、液晶組成物を構成する液晶材料の
開発によりこれらを改善することが求められている。Therefore, liquid crystal compositions for liquid crystal display devices such as TN, STN and AM-LCD have the following properties: (1) Wide liquid crystal phase temperature range that can be used outdoors (2) Low threshold voltage (3) Fast response (4) ) Compatibility with other liquid crystal materials is required, and it is required to improve these by developing liquid crystal materials constituting the liquid crystal composition.

【０００４】液晶化合物は通常コアと呼ばれる中心骨格
部分と両側の末端部分から構成されている。通常、液晶
化合物のコア部分を構成する環構造としては1,4-フェニ
レン基(1〜2個のハロゲン原子、シアノ基、メチル基等
により置換されていることもある)及びトランス-1,4-シ
クロヘキシレン基がその大部分を占める。しかしながら
1,4-フェニレン基とトランス-1,4-シクロヘキシレン基
のみによって構成された液晶性化合物にはその種類や特
性にも限界があり、それらだけでは前記要求に応えきれ
なくなっているのが実情である。1,4-フェニレン基とト
ランス-1,4-シクロヘキシレン基以外の環構造として、
ナフタレン-2,6-ジイル基、テトラヒドロナフタレン-2,
6-ジイル基等の縮合環系、さらにこれらのコア部へのフ
ッ素原子を導入した化合物も検討されている。特開2001
-19648あるいはドイツ公開特許公報19652247号にはテト
ラヒドロナフタレン-2,6-ジイル基を有する液晶化合物
が開示されている。これらに記載されている液晶化合物
を表示素子に用いた場合、閾値電圧の低減には比較的効
果的であり、レスポンスも現在求められている動画表示
には対応可能である。しかしながら、今後求められる、
より大型で精細な液晶ディスプレイへにはより早いレス
ポンス及び低い閾値電圧が同時に求められており、次世
代液晶テレビ等に対応するための優れた液晶材料及びこ
れを用い液晶組成物が強く求められていた。The liquid crystal compound is usually composed of a central skeleton portion called a core and terminal portions on both sides. Usually, as the ring structure constituting the core portion of the liquid crystal compound, 1,4-phenylene group (may be substituted with 1 to 2 halogen atoms, cyano group, methyl group, etc.) and trans-1,4 -The cyclohexylene group accounts for the majority. However
Liquid crystal compounds composed of only 1,4-phenylene group and trans-1,4-cyclohexylene group have limitations in their types and characteristics, and it is the actual situation that they cannot meet the above requirements. Is. As a ring structure other than a 1,4-phenylene group and a trans-1,4-cyclohexylene group,
Naphthalene-2,6-diyl group, tetrahydronaphthalene-2,
Condensed ring systems such as 6-diyl groups, and compounds in which a fluorine atom is introduced into these cores are also being investigated. JP 2001
-19648 or German Laid-Open Patent Publication No. 19652247 discloses a liquid crystal compound having a tetrahydronaphthalene-2,6-diyl group. When the liquid crystal compounds described in these are used for the display element, they are relatively effective in reducing the threshold voltage, and can respond to the moving image display that is currently required. However, in the future,
Larger and finer liquid crystal displays are required to have faster response and lower threshold voltage at the same time, and there is a strong demand for excellent liquid crystal materials and liquid crystal compositions using the same, which are compatible with next-generation liquid crystal televisions and the like. It was

【０００５】[0005]

【発明が解決しようとする課題】本発明が解決しようと
する課題は、液晶相温度範囲及び他の液晶材料との相溶
性を従来より改善するかあるいは悪化させることなく、
レスポンス及び閾値電圧を効果的に低減することの可能
な液晶化合物を提供することにある。また、それを用い
て実用的な液晶組成物及び液晶表示素子を提供すること
にある。The problem to be solved by the present invention is to improve or not worsen the liquid crystal phase temperature range and the compatibility with other liquid crystal materials as compared with the conventional ones.
It is to provide a liquid crystal compound capable of effectively reducing the response and the threshold voltage. Another object is to provide a practical liquid crystal composition and liquid crystal display device using the same.

【０００６】[0006]

【課題を解決するための手段】本発明は、上記課題を解
決するためにジヒドロナフタレン環を有する新規液晶性
化合物を見いだした。The present invention has found a novel liquid crystalline compound having a dihydronaphthalene ring in order to solve the above problems.

【０００７】すなわち本発明は、一般式(1)That is, the present invention has the general formula (1)

【化２】 [Chemical 2]

【０００８】(式中、Rは炭素原子数1〜20のアルキル
基、炭素原子数1〜20のアルコキシル基、炭素原子数2〜
20のアルケニル基又は炭素原子数2〜20のアルケニルオ
キシ基を表しこれらは炭素原子数1〜7のアルコキシル基
又は1〜7個のハロゲン原子によって置換されていてもよ
く、m、n、q、tはそれぞれ独立に0又は1を表し、A、B、
C及びDはそれぞれ独立にトランス-1,4-シクロへキシレ
ン基、トランス,トランス-ビシクロヘキサン-4,4'-ジイ
ル基、ビシクロ[2.2.2]オクタン-1,4-ジイル基、又は1
個以上のハロゲン原子により置換されていてもよい、1,
4-フェニレン基、ピリジン-2,5-ジイル基、ピリミジン-
2,5-ジイル基、ピラジン-2,5-ジイル基、ピリダジン-3,
6-ジイル基、トランス-1,3-ジオキサン-2,5-ジイル基、
トランスデカヒドロナフタレン-2,6-ジイル基、テトラ
ヒドロナフタレン-2,6-ジイル基、ナフタレン-2,6-ジイ
ル基を表し、L、M、Q、Tはそれぞれ独立に-CH2CH2-、-C
H2CH2CH 2CH2-、-CH=CH-、-CH=CHCH2CH2-、-CH2CH2CH=CH
-、-CH(CH3)CH2-、-CH2CH(CH3)-、-CF=CF-、-CH2O-、-O
CH2-、-CF2O-、-OCF2-、-COO-、-OCO-、-C≡C-又は単結
合を表し、X1及びX2は塩素原子又はフッ素原子を表し、
Zは、水素原子、ハロゲン原子、シアノ基、シアナト
基、-SCN、又は、1個以上のフッ素原子によって置換さ
れていてもよい炭素原子数1〜20のアルキル基、アルコ
キシル基、アルケニル基、アルケニルオキシ基を表
す。)で表されるジヒドロナフタレン誘導体を提供し、
またそれを用いて実用的な液晶組成物及び液晶表示素子
を提供する。(In the formula, R is an alkyl having 1 to 20 carbon atoms.
Group, alkoxyl group having 1 to 20 carbon atoms, 2 to carbon atoms
20 alkenyl groups or alkenyl groups having 2 to 20 carbon atoms
Represents an oxy group and is an alkoxyl group having 1 to 7 carbon atoms.
Or optionally substituted by 1 to 7 halogen atoms
, M, n, q, t each independently represent 0 or 1, A, B,
C and D are independently trans-1,4-cyclohexyl
Group, trans, trans-bicyclohexane-4,4'-di
Group, bicyclo [2.2.2] octane-1,4-diyl group, or 1
Optionally substituted by one or more halogen atoms, 1,
4-phenylene group, pyridine-2,5-diyl group, pyrimidine-
2,5-diyl group, pyrazine-2,5-diyl group, pyridazine-3,
6-diyl group, trans-1,3-dioxane-2,5-diyl group,
Transdecahydronaphthalene-2,6-diyl group, tetra
Hydronaphthalene-2,6-diyl group, naphthalene-2,6-diyl group
Group, L, M, Q, and T are independently -CH2CH2-, -C
H2CH2CH 2CH2-, -CH = CH-, -CH = CHCH2CH2-, -CH2CH2CH = CH
-, -CH (CH3) CH2-, -CH2CH (CH3)-, -CF = CF-, -CH2O-, -O
CH2-,-CF2O-, -OCF2-, -COO-, -OCO-, -C≡C- or single bond
Represents X, and X1And X2Represents a chlorine atom or a fluorine atom,
Z is a hydrogen atom, halogen atom, cyano group, cyanato
Substituted by a group, -SCN, or one or more fluorine atoms.
Optionally substituted alkyl group having 1 to 20 carbon atoms,
Shows xyl, alkenyl, and alkenyloxy groups.
You ) Provides a dihydronaphthalene derivative represented by
Further, a practical liquid crystal composition and liquid crystal display device using the same
I will provide a.

【０００９】[0009]

【発明の実施の形態】以下に本発明について詳細に説明
する。X1及びX2は、少なくともひとつがフッ素原子を表
すことが好ましく、X1がフッ素原子を表すことがより好
ましく、X1及びX2がフッ素原子を表すことが更に好まし
い。BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail below. X 1 and X 2 is preferably representative of at least one fluorine atom, more preferably X 1 represents a fluorine atom, X 1 and X 2 It is further preferred that a fluorine atom.

【００１０】m、n、q及びtは、m = 1なおかつn = q = t
= 0、m = n = q = 0なおかつt = 1、m = n = 1なおか
つq = t = 0、m = t = 1なおかつn = q = 0、m = n = 0
なおかつq = t = 1、m = n = t = 1なおかつq = 0又はm
= q = t = 1なおかつn = 0が好ましい。M, n, q and t are m = 1 and n = q = t
= 0, m = n = q = 0 and t = 1, m = n = 1 and q = t = 0, m = t = 1 and n = q = 0, m = n = 0
And q = t = 1, m = n = t = 1, and q = 0 or m
= q = t = 1 and n = 0 is preferred.

【００１１】A、B、C及びDは、それぞれ独立にトランス
-1,4-シクロへキシレン基、トランス,トランス-ビシク
ロヘキサン-4,4'-ジイル基、又は1個以上のハロゲン原
子により置換されていてもよい、1,4-フェニレン基、ピ
リジン-2,5-ジイル基、ピリミジン-2,5-ジイル基、ピラ
ジン-2,5-ジイル基、ピリダジン-3,6-ジイル基、トラン
ス-1,3-ジオキサン-2,5-ジイル基、トランスデカヒドロ
ナフタレン-2,6-ジイル基、テトラヒドロナフタレン-2,
6-ジイル基又はナフタレン-2,6-ジイル基を表すことが
好ましいが、トランス-1,4-シクロへキシレン基、トラ
ンス,トランス-ビシクロヘキサン-4,4'-ジイル基又は1
個以上のハロゲン原子により置換されていてもよい1,4-
フェニレン基を表すことがより好ましく、トランス-1,4
-シクロへキシレン基、1,4-フェニレン基、3-フルオロ-
1,4-フェニレン基、3,5-ジフルオロ-1,4-フェニレン基
が更に好ましい。特にDとしては1,4-フェニレン基、3-
フルオロ-1,4-フェニレン基又は3,5-ジフルオロ-1,4-フ
ェニレン基を表すことが好ましい。A, B, C and D are independent transformers.
-1,4-cyclohexylene group, trans, trans-bicyclohexane-4,4'-diyl group, or optionally substituted by one or more halogen atoms, 1,4-phenylene group, pyridine-2 , 5-diyl group, pyrimidine-2,5-diyl group, pyrazine-2,5-diyl group, pyridazine-3,6-diyl group, trans-1,3-dioxane-2,5-diyl group, transdeca Hydronaphthalene-2,6-diyl group, tetrahydronaphthalene-2,
It is preferable to represent a 6-diyl group or naphthalene-2,6-diyl group, but a trans-1,4-cyclohexylene group, trans, trans-bicyclohexane-4,4'-diyl group or 1
1,4-optionally substituted by one or more halogen atoms
More preferably it represents a phenylene group, trans-1,4
-Cyclohexylene group, 1,4-phenylene group, 3-fluoro-
A 1,4-phenylene group and a 3,5-difluoro-1,4-phenylene group are more preferable. Especially as D, 1,4-phenylene group, 3-
It preferably represents a fluoro-1,4-phenylene group or a 3,5-difluoro-1,4-phenylene group.

【００１２】Rは、炭素原子数1〜20のアルキル基、炭素
原子数1〜20のアルコキシル基、炭素原子数2〜20のアル
ケニル基又は炭素原子数2〜20のアルケニルオキシ基を
表すことが好ましく、炭素原子数1〜12の直鎖アルキル
基、炭素原子数1〜12の直鎖アルコキシル基、炭素原子
数2〜12の直鎖アルケニル基又は炭素原子数2〜12の直鎖
アルケニルオキシ基を表すことが更に好ましく、炭素原
子数1〜7の直鎖アルキル基又は炭素原子数2〜7の直鎖ア
ルケニル基を表すことが特に好ましい。また、m= n = 0
の場合、Rはアルキル基又はアルケニル基を表すことが好
ましく、直鎖アルキル基又は直鎖アルケニル基を表すこ
とが更に好ましく、炭素原子数1〜7の直鎖アルキル基又
は直鎖アルケニル基を表すことが特に好ましい。R represents an alkyl group having 1 to 20 carbon atoms, an alkoxyl group having 1 to 20 carbon atoms, an alkenyl group having 2 to 20 carbon atoms or an alkenyloxy group having 2 to 20 carbon atoms. Preferably, a linear alkyl group having 1 to 12 carbon atoms, a linear alkoxy group having 1 to 12 carbon atoms, a linear alkenyl group having 2 to 12 carbon atoms or a linear alkenyloxy group having 2 to 12 carbon atoms. Is more preferably represented, and particularly preferably a linear alkyl group having 1 to 7 carbon atoms or a linear alkenyl group having 2 to 7 carbon atoms. Also, m = n = 0
In the case of, R is preferably an alkyl group or an alkenyl group, more preferably a linear alkyl group or a linear alkenyl group, and more preferably a linear alkyl group or a linear alkenyl group having 1 to 7 carbon atoms. Is particularly preferred.

【００１３】L、M、Q及びTは、それぞれ独立に-CH2CH
2-、-CH=CH-、-CH(CH3)CH2-、-CH2CH(CH3)-、-CF=CF-、
-CH2O-、-OCH2-、-CF2O-、-OCF2-、-COO-、-OCO-、-C≡
C-又は単結合を表すことが好ましく、-CH2CH2-、-CF=CF
-、-CH2O-、-OCH2-、-CF2O-、-OCF2-、-COO-、-OCO-、-
C≡C-又は単結合を表すことが更に好ましく、-CH2CH
2-、-CF=CF-、-CF2O-、-OCF2-、-C≡C-又は単結合を表
すことが特に好ましい。また、m = 1かつn = 0の場合、L
は-COO-、-CF2O-、-CH2O-以外を表すことが好ましい。
また、m = 0かつn = 1の場合、Mは-COO-、-CF2O-、-CH2O
-以外を表すことが好ましい。L, M, Q and T are independently -CH 2 CH
2- , -CH = CH-, -CH (CH 3 ) CH 2- , -CH 2 CH (CH 3 )-, -CF = CF-,
-CH 2 O -, - OCH 2 -, - CF 2 O -, - OCF 2 -, - COO -, - OCO -, - C≡
It is preferable to represent C- or a single bond, -CH 2 CH 2- , -CF = CF
-, -CH 2 O-, -OCH 2- , -CF 2 O-, -OCF 2- , -COO-, -OCO-,-
More preferably, it represents C≡C- or a single bond, and —CH 2 CH
2 -, - CF = CF - , - CF 2 O -, - OCF 2 -, - C≡C- or and particularly preferably a single bond. If m = 1 and n = 0, L
Preferably represents other than -COO-, -CF 2 O-, and -CH 2 O-.
When m = 0 and n = 1, M is -COO-, -CF 2 O-, -CH 2 O.
It is preferable to represent other than.

【００１４】Zは、水素原子、フッ素原子、塩素原子、
シアノ基、1個以上のフッ素原子によって置換されてい
てもよい炭素原子数1〜9のアルキル基、1個以上のフッ
素原子によって置換されていてもよい炭素原子数1〜9の
アルコキシル基、1個以上のフッ素原子によって置換さ
れていてもよい炭素原子数2〜9のアルケニル基又は1個
以上のフッ素原子によって置換されていてもよい炭素原
子数2〜9のアルケニルオキシ基を表すことが好ましく、
フッ素原子、シアノ基、1個以上のフッ素原子によって
置換されていてもよい炭素原子数1〜5のアルキル基、1
個以上のフッ素原子によって置換されていてもよい炭素
原子数1〜5のアルコキシル基、1個以上のフッ素原子に
よって置換されていてもよい炭素原子数2〜5のアルケニ
ル基又は1個以上のフッ素原子によって置換されていて
もよい炭素原子数2〜5のアルケニルオキシ基を表すこと
がより好ましく、フッ素原子、シアノ基、フルオロメト
キシ基、ジフルオロメトキシ基、トリフルオロメトキシ
基、フルオロメチル基、ジフルオロメチル基又はトリフ
ルオロメチル基を表すことが更に好ましく、フッ素原
子、シアノ基、フルオロメトキシ基、ジフルオロメトキ
シ基又はトリフルオロメトキシ基を表すことが特に好ま
しい。また、q = t = 0である場合Zは水素原子以外を表
すことが好ましい。Z is a hydrogen atom, a fluorine atom, a chlorine atom,
A cyano group, an alkyl group having 1 to 9 carbon atoms which may be substituted by one or more fluorine atoms, an alkoxyl group having 1 to 9 carbon atoms which may be substituted by one or more fluorine atoms, 1 It is preferable to represent an alkenyl group having 2 to 9 carbon atoms which may be substituted by one or more fluorine atoms or an alkenyloxy group having 2 to 9 carbon atoms which may be substituted by one or more fluorine atoms. ,
Fluorine atom, cyano group, alkyl group having 1 to 5 carbon atoms optionally substituted by one or more fluorine atoms, 1
Alkoxyl group having 1 to 5 carbon atoms which may be substituted by 1 or more fluorine atoms, alkenyl group having 2 to 5 carbon atoms which may be substituted by 1 or more fluorine atoms or 1 or more fluorine More preferably, it represents an alkenyloxy group having 2 to 5 carbon atoms which may be substituted by an atom, a fluorine atom, a cyano group, a fluoromethoxy group, a difluoromethoxy group, a trifluoromethoxy group, a fluoromethyl group, a difluoromethyl group. A group or a trifluoromethyl group is more preferable, and a fluorine atom, a cyano group, a fluoromethoxy group, a difluoromethoxy group or a trifluoromethoxy group is particularly preferable. Further, when q = t = 0, Z preferably represents other than a hydrogen atom.

【００１５】以下、具体的に化合物を例示する。尚、以
下例示の化合物記載に下記の略号を使用する。nは直鎖
アルキル基の炭素数を表す。アルケニル基において、m
は環から数えて何番目に二重結合が付いているかを表
し、nは二重結合の先の炭素数を表す。 n (数字) ：CnH2n+1 nO ：CnH2n+1O -ndm ：-(CnH2n+1-CH=CH-(CH2)m-1) ndm- ：CnH2n+1-CH=CH-(CH2)m-1- -Od(m)n ：-O(CnH2n+1-CH=CH-(CH2)m-2) d(m)nO- ：CnH2n+1-CH=CH-(CH2)m-2O- また、以下の略号を使用する。 -VO- : -COO- -OV- : -OCO- -T- : -C≡C- -2- : -CH2CH2- -3- : -CH2CH2CH2- -3a- : -CH(CH3)CH2- -3b- : -CH2CH(CH3)- -4- : -CH2CH2CH2CH2- -1O- : -CH2-O- -O1- : -O-CH2- -G- : -CF=CF- -D- : -CH=CH- -2D- : -CH2CH2CH=CH- -D2- : -CH=CHCH2CH2- -J- : -CF2O- -K- : -OCF2- -H : 水素原子 -CN : シアノ基 -F : フッ素原子 -Cl : 塩素原子 -OCF3 : トリフルオロメトキシ基 -OCHF2 : ジフルオロメトキシ基The compounds will be specifically exemplified below. The following abbreviations are used in the description of the compounds exemplified below. n represents the carbon number of the linear alkyl group. In the alkenyl group, m
Represents the position of the double bond counted from the ring, and n represents the number of carbon atoms beyond the double bond. n (number): C n H 2n + 1 nO: C n H 2n + 1 O -ndm:-(C n H 2n + 1 -CH = CH- (CH 2 ) m-1 ) ndm-: C n H 2n + 1 -CH = CH- (CH 2 ) m-1 --Od (m) n: -O (C n H 2n + 1 -CH = CH- (CH 2 ) m-2 ) d (m) nO -: C n H 2n + 1 -CH = CH- (CH 2) m-2 O- also, the following abbreviations are used. -VO-: -COO- -OV-: -OCO- -T-: -C≡C- -2-: -CH 2 CH 2 - -3-: -CH 2 CH 2 CH 2 - -3a-: - CH (CH 3) CH 2 - -3b-: -CH 2 CH (CH 3) - -4-: -CH 2 CH 2 CH 2 CH 2 - -1O-: -CH 2 -O- -O1-: - O-CH 2 --G-: -CF = CF- -D-: -CH = CH- -2D-: -CH 2 CH 2 CH = CH- -D2-: -CH = CHCH 2 CH 2 --J -: -CF 2 O- -K-: -OCF 2 --H: Hydrogen atom-CN: Cyano group-F: Fluorine atom-Cl: Chlorine atom-OCF3: Trifluoromethoxy group-OCHF2: Difluoromethoxy group

【００１６】[0016]

【化３】 [Chemical 3]

【００１７】[0017]

【化４】 例えば[Chemical 4] For example

【化５】 のように表す。[Chemical 5] It is expressed as.

【００１８】R-Xa-Ph-Z、R-Xa-VO-Ph-Z、R-Xa-Cy-Z、R-
Xa-VO-Cy-Z、R-Xa-T-Ph-Z、R-Xa-G-Ph-Z、R-Xa-J-Ph-
Z、R-Xa-K-Ph-Z、R-Xa-Ph1-Z、R-Xa-Ph3-Z、R-Xb-Ph-
Z、R-Xb-G-Ph-Z、R-Xb-J-Ph-Z、R-By-Xa-ZR-Xa-Ph-Z, R-Xa-VO-Ph-Z, R-Xa-Cy-Z, R-
Xa-VO-Cy-Z, R-Xa-T-Ph-Z, R-Xa-G-Ph-Z, R-Xa-J-Ph-
Z, R-Xa-K-Ph-Z, R-Xa-Ph1-Z, R-Xa-Ph3-Z, R-Xb-Ph-
Z, R-Xb-G-Ph-Z, R-Xb-J-Ph-Z, R-By-Xa-Z

【００１９】R-Cy-Xa-Z、R-Cy-Xc-Z、R-Cy-Xa-Z、R-Cy-
Xb-Z、R-Cy-Xd-Z、R-Cy-Xa-Z、R-Cy-2-Xa-Z、R-Cy-VO-X
a-Z、R-Cy-G-Xa-Z、R-Cy-J-Xa-Z、R-Cy-K-Xa-Z、R-Ph-X
a-Z、R-Ph1-Xa-Z、R-Ph3-Xa-Z、R-Cy-Xa-Ph-Z、R-Cy-Xa
-Ph1-Z、R-Cy-Xa-Ph3-Z、R-Cy-Xa-VO-Ph-Z、R-Cy-Xa-VO
-Ph1-Z、R-Cy-Xa-VO-Ph3-Z、R-Cy-Xa-T-Ph-Z、R-Cy-Xa-
T-Ph1-Z、R-Cy-Xa-T-Ph3-Z、R-Cy-Xa-G-Ph-Z、R-Cy-Xa-
G-Ph1-Z、R-Cy-Xa-G-Ph3-Z、R-Cy-Xa-J-Ph-Z、R-Cy-Xa-
J-Ph1-Z、R-Cy-Xa-J-Ph3-Z、R-Cy-VO-Xa-Ph-Z、R-Cy-VO
-Xa-Ph1-Z、R-Cy-VO-Xa-Ph3-Z、R-Cy-VO-Xa-VO-Ph-Z、R
-Cy-VO-Xa-VO-Ph1-Z、R-Cy-VO-Xa-VO-Ph3-Z、R-Cy-VO-X
a-T-Ph-Z、R-Cy-VO-Xa-T-Ph1-Z、R-Cy-VO-Xa-T-Ph3-Z、
R-Cy-VO-Xa-G-Ph-Z、R-Cy-VO-Xa-G-Ph1-Z、R-Cy-VO-Xa-
G-Ph3-Z、R-Cy-VO-Xa-J-Ph-Z、R-Cy-VO-Xa-J-Ph1-Z、R-
Cy-VO-Xa-J-Ph3-Z、R-Cy-2-Xa-Ph-Z、R-Cy-2-Xa-Ph1-
Z、R-Cy-2-Xa-Ph3-Z、R-Cy-2-Xa-VO-Ph-Z、R-Cy-2-Xa-V
O-Ph1-Z、R-Cy-2-Xa-VO-Ph3-Z、R-Cy-2-Xa-T-Ph-Z、R-C
y-2-Xa-T-Ph1-Z、R-Cy-2-Xa-T-Ph3-Z、R-Cy-2-Xa-G-Ph-
Z、R-Cy-2-Xa-G-Ph1-Z、R-Cy-2-Xa-G-Ph3-Z、R-Cy-2-Xa
-J-Ph-Z、R-Cy-2-Xa-J-Ph1-Z、R-Cy-2-Xa-J-Ph3-Z、R-C
y-G-Xa-Ph-Z、R-Cy-G-Xa-Ph1-Z、R-Cy-G-Xa-Ph3-Z、R-C
y-G-Xa-VO-Ph-Z、R-Cy-G-Xa-VO-Ph1-Z、R-Cy-G-Xa-VO-P
h3-Z、R-Cy-G-Xa-T-Ph-Z、R-Cy-G-Xa-T-Ph1-Z、R-Cy-G-
Xa-T-Ph3-Z、R-Cy-G-Xa-G-Ph-Z、R-Cy-G-Xa-G-Ph1-Z、R
-Cy-G-Xa-G-Ph3-Z、R-Cy-G-Xa-J-Ph-Z、R-Cy-G-Xa-J-Ph
1-Z、R-Cy-G-Xa-J-Ph3-Z、R-Cy-J-Xa-Ph-Z、R-Cy-J-Xa-
Ph1-Z、R-Cy-J-Xa-Ph3-Z、R-Cy-J-Xa-VO-Ph-Z、R-Cy-J-
Xa-VO-Ph1-Z、R-Cy-J-Xa-VO-Ph3-Z、R-Cy-J-Xa-T-Ph-
Z、R-Cy-J-Xa-T-Ph1-Z、R-Cy-J-Xa-T-Ph3-Z、R-Cy-J-Xa
-G-Ph-Z、R-Cy-J-Xa-G-Ph1-Z、R-Cy-J-Xa-G-Ph3-Z、R-C
y-J-Xa-J-Ph-Z、R-Cy-J-Xa-J-Ph1-Z、R-Cy-J-Xa-J-Ph3-
Z、R-Cy-Xb-Ph-Z、R-Cy-Xb-Ph1-Z、R-Cy-Xb-Ph3-Z、R-C
y-Xb-VO-Ph-Z、R-Cy-Xb-VO-Ph1-Z、R-Cy-Xb-T-Ph-Z、R-
Cy-Xb-T-Ph-Z、R-Cy-Xb-T-Ph1-Z、R-Cy-Xb-G-Ph-Z、R-C
y-Xb-G-Ph1-Z、R-Cy-Xb-G-Ph3-Z、R-Cy-Xb-J-Ph-Z、R-C
y-Xb-J-Ph1-Z、R-Cy-VO-Xb-Ph-Z、R-Cy-VO-Xb-Ph1-Z、R
-Cy-VO-Xb-Ph3-Z、R-Cy-VO-Xb-VO-Ph-Z、R-Cy-VO-Xb-VO
-Ph1-Z、R-Cy-VO-Xb-VO-Ph3-Z、R-Cy-VO-Xb-T-Ph-Z、R-
Cy-VO-Xb-T-Ph1-Z、R-Cy-VO-Xb-T-Ph3-Z、R-Cy-VO-Xb-G
-Ph-Z、R-Cy-VO-Xb-G-Ph1-Z、R-Cy-VO-Xb-G-Ph3-Z、R-C
y-VO-Xb-J-Ph-Z、R-Cy-VO-Xb-J-Ph1-Z、R-Cy-VO-Xb-J-P
h3-Z、R-Cy-2-Xb-Ph-Z、R-Cy-2-Xb-Ph1-Z、R-Cy-2-Xb-P
h3-Z、R-Cy-2-Xb-VO-Ph-Z、R-Cy-2-Xb-VO-Ph1-Z、R-Cy-
2-Xb-VO-Ph3-Z、R-Cy-2-Xb-T-Ph-Z、R-Cy-2-Xb-T-Ph1-
Z、R-Cy-2-Xb-T-Ph3-Z、R-Cy-2-Xb-G-Ph-Z、R-Cy-2-Xb-
G-Ph1-Z、R-Cy-2-Xb-G-Ph3-Z、R-Cy-2-Xb-J-Ph-Z、R-Cy
-2-Xb-J-Ph1-Z、R-Cy-2-Xb-J-Ph3-Z、R-Cy-G-Xb-Ph-Z、
R-Cy-G-Xb-Ph1-Z、R-Cy-G-Xb-Ph3-Z、R-Cy-G-Xb-VO-Ph-
Z、R-Cy-G-Xb-VO-Ph1-Z、R-Cy-G-Xb-VO-Ph3-Z、R-Cy-G-
Xb-T-Ph-Z、R-Cy-G-Xb-T-Ph1-Z、R-Cy-G-Xb-T-Ph3-Z、R
-Cy-G-Xb-G-Ph-Z、R-Cy-G-Xb-G-Ph1-Z、R-Cy-G-Xb-G-Ph
3-Z、R-Cy-G-Xb-J-Ph-Z、R-Cy-G-Xb-J-Ph1-Z、R-Cy-G-X
b-J-Ph3-Z、R-Cy-J-Xb-Ph-Z、R-Cy-J-Xb-Ph1-Z、R-Cy-J
-Xb-Ph3-Z、R-Cy-J-Xb-VO-Ph-Z、R-Cy-J-Xb-VO-Ph1-Z、
R-Cy-J-Xb-VO-Ph3-Z、R-Cy-J-Xb-T-Ph-Z、R-Cy-J-Xb-T-
Ph1-Z、R-Cy-J-Xb-T-Ph3-Z、R-Cy-J-Xb-G-Ph-Z、R-Cy-J
-Xb-G-Ph1-Z、R-Cy-J-Xb-G-Ph3-Z、R-Cy-J-Xb-J-Ph-Z、
R-Cy-J-Xb-J-Ph1-Z、R-Cy-J-Xb-J-Ph3-ZR-Cy-Xa-Z, R-Cy-Xc-Z, R-Cy-Xa-Z, R-Cy-
Xb-Z, R-Cy-Xd-Z, R-Cy-Xa-Z, R-Cy-2-Xa-Z, R-Cy-VO-X
aZ, R-Cy-G-Xa-Z, R-Cy-J-Xa-Z, R-Cy-K-Xa-Z, R-Ph-X
aZ, R-Ph1-Xa-Z, R-Ph3-Xa-Z, R-Cy-Xa-Ph-Z, R-Cy-Xa
-Ph1-Z, R-Cy-Xa-Ph3-Z, R-Cy-Xa-VO-Ph-Z, R-Cy-Xa-VO
-Ph1-Z, R-Cy-Xa-VO-Ph3-Z, R-Cy-Xa-T-Ph-Z, R-Cy-Xa-
T-Ph1-Z, R-Cy-Xa-T-Ph3-Z, R-Cy-Xa-G-Ph-Z, R-Cy-Xa-
G-Ph1-Z, R-Cy-Xa-G-Ph3-Z, R-Cy-Xa-J-Ph-Z, R-Cy-Xa-
J-Ph1-Z, R-Cy-Xa-J-Ph3-Z, R-Cy-VO-Xa-Ph-Z, R-Cy-VO
-Xa-Ph1-Z, R-Cy-VO-Xa-Ph3-Z, R-Cy-VO-Xa-VO-Ph-Z, R
-Cy-VO-Xa-VO-Ph1-Z, R-Cy-VO-Xa-VO-Ph3-Z, R-Cy-VO-X
aT-Ph-Z, R-Cy-VO-Xa-T-Ph1-Z, R-Cy-VO-Xa-T-Ph3-Z,
R-Cy-VO-Xa-G-Ph-Z, R-Cy-VO-Xa-G-Ph1-Z, R-Cy-VO-Xa-
G-Ph3-Z, R-Cy-VO-Xa-J-Ph-Z, R-Cy-VO-Xa-J-Ph1-Z, R-
Cy-VO-Xa-J-Ph3-Z, R-Cy-2-Xa-Ph-Z, R-Cy-2-Xa-Ph1-
Z, R-Cy-2-Xa-Ph3-Z, R-Cy-2-Xa-VO-Ph-Z, R-Cy-2-Xa-V
O-Ph1-Z, R-Cy-2-Xa-VO-Ph3-Z, R-Cy-2-Xa-T-Ph-Z, RC
y-2-Xa-T-Ph1-Z, R-Cy-2-Xa-T-Ph3-Z, R-Cy-2-Xa-G-Ph-
Z, R-Cy-2-Xa-G-Ph1-Z, R-Cy-2-Xa-G-Ph3-Z, R-Cy-2-Xa
-J-Ph-Z, R-Cy-2-Xa-J-Ph1-Z, R-Cy-2-Xa-J-Ph3-Z, RC
yG-Xa-Ph-Z, R-Cy-G-Xa-Ph1-Z, R-Cy-G-Xa-Ph3-Z, RC
yG-Xa-VO-Ph-Z, R-Cy-G-Xa-VO-Ph1-Z, R-Cy-G-Xa-VO-P
h3-Z, R-Cy-G-Xa-T-Ph-Z, R-Cy-G-Xa-T-Ph1-Z, R-Cy-G-
Xa-T-Ph3-Z, R-Cy-G-Xa-G-Ph-Z, R-Cy-G-Xa-G-Ph1-Z, R
-Cy-G-Xa-G-Ph3-Z, R-Cy-G-Xa-J-Ph-Z, R-Cy-G-Xa-J-Ph
1-Z, R-Cy-G-Xa-J-Ph3-Z, R-Cy-J-Xa-Ph-Z, R-Cy-J-Xa-
Ph1-Z, R-Cy-J-Xa-Ph3-Z, R-Cy-J-Xa-VO-Ph-Z, R-Cy-J-
Xa-VO-Ph1-Z, R-Cy-J-Xa-VO-Ph3-Z, R-Cy-J-Xa-T-Ph-
Z, R-Cy-J-Xa-T-Ph1-Z, R-Cy-J-Xa-T-Ph3-Z, R-Cy-J-Xa
-G-Ph-Z, R-Cy-J-Xa-G-Ph1-Z, R-Cy-J-Xa-G-Ph3-Z, RC
yJ-Xa-J-Ph-Z, R-Cy-J-Xa-J-Ph1-Z, R-Cy-J-Xa-J-Ph3-
Z, R-Cy-Xb-Ph-Z, R-Cy-Xb-Ph1-Z, R-Cy-Xb-Ph3-Z, RC
y-Xb-VO-Ph-Z, R-Cy-Xb-VO-Ph1-Z, R-Cy-Xb-T-Ph-Z, R-
Cy-Xb-T-Ph-Z, R-Cy-Xb-T-Ph1-Z, R-Cy-Xb-G-Ph-Z, RC
y-Xb-G-Ph1-Z, R-Cy-Xb-G-Ph3-Z, R-Cy-Xb-J-Ph-Z, RC
y-Xb-J-Ph1-Z, R-Cy-VO-Xb-Ph-Z, R-Cy-VO-Xb-Ph1-Z, R
-Cy-VO-Xb-Ph3-Z, R-Cy-VO-Xb-VO-Ph-Z, R-Cy-VO-Xb-VO
-Ph1-Z, R-Cy-VO-Xb-VO-Ph3-Z, R-Cy-VO-Xb-T-Ph-Z, R-
Cy-VO-Xb-T-Ph1-Z, R-Cy-VO-Xb-T-Ph3-Z, R-Cy-VO-Xb-G
-Ph-Z, R-Cy-VO-Xb-G-Ph1-Z, R-Cy-VO-Xb-G-Ph3-Z, RC
y-VO-Xb-J-Ph-Z, R-Cy-VO-Xb-J-Ph1-Z, R-Cy-VO-Xb-JP
h3-Z, R-Cy-2-Xb-Ph-Z, R-Cy-2-Xb-Ph1-Z, R-Cy-2-Xb-P
h3-Z, R-Cy-2-Xb-VO-Ph-Z, R-Cy-2-Xb-VO-Ph1-Z, R-Cy-
2-Xb-VO-Ph3-Z, R-Cy-2-Xb-T-Ph-Z, R-Cy-2-Xb-T-Ph1-
Z, R-Cy-2-Xb-T-Ph3-Z, R-Cy-2-Xb-G-Ph-Z, R-Cy-2-Xb-
G-Ph1-Z, R-Cy-2-Xb-G-Ph3-Z, R-Cy-2-Xb-J-Ph-Z, R-Cy
-2-Xb-J-Ph1-Z, R-Cy-2-Xb-J-Ph3-Z, R-Cy-G-Xb-Ph-Z,
R-Cy-G-Xb-Ph1-Z, R-Cy-G-Xb-Ph3-Z, R-Cy-G-Xb-VO-Ph-
Z, R-Cy-G-Xb-VO-Ph1-Z, R-Cy-G-Xb-VO-Ph3-Z, R-Cy-G-
Xb-T-Ph-Z, R-Cy-G-Xb-T-Ph1-Z, R-Cy-G-Xb-T-Ph3-Z, R
-Cy-G-Xb-G-Ph-Z, R-Cy-G-Xb-G-Ph1-Z, R-Cy-G-Xb-G-Ph
3-Z, R-Cy-G-Xb-J-Ph-Z, R-Cy-G-Xb-J-Ph1-Z, R-Cy-GX
bJ-Ph3-Z, R-Cy-J-Xb-Ph-Z, R-Cy-J-Xb-Ph1-Z, R-Cy-J
-Xb-Ph3-Z, R-Cy-J-Xb-VO-Ph-Z, R-Cy-J-Xb-VO-Ph1-Z,
R-Cy-J-Xb-VO-Ph3-Z, R-Cy-J-Xb-T-Ph-Z, R-Cy-J-Xb-T-
Ph1-Z, R-Cy-J-Xb-T-Ph3-Z, R-Cy-J-Xb-G-Ph-Z, R-Cy-J
-Xb-G-Ph1-Z, R-Cy-J-Xb-G-Ph3-Z, R-Cy-J-Xb-J-Ph-Z,
R-Cy-J-Xb-J-Ph1-Z, R-Cy-J-Xb-J-Ph3-Z

【００２０】R-Ph-Xa-Ph-Z、R-Ph-Xa-Ph1-Z、R-Ph-Xa-P
h3-Z、R-Ph-Xa-VO-Ph-Z、R-Ph-Xa-VO-Ph1-Z、R-Ph-Xa-V
O-Ph3-Z、R-Ph-Xa-T-Ph-Z、R-Ph-Xa-T-Ph1-Z、R-Ph-Xa-
T-Ph3-Z、R-Ph-Xa-G-Ph-Z、R-Ph-Xa-G-Ph1-Z、R-Ph-Xa-
G-Ph3-Z、R-Ph-Xa-J-Ph-Z、R-Ph-Xa-J-Ph1-Z、R-Ph-Xa-
J-Ph3-Z、R-Ph-VO-Xa-Ph-Z、R-Ph-VO-Xa-Ph1-Z、R-Ph-V
O-Xa-Ph3-Z、R-Ph-VO-Xa-VO-Ph-Z、R-Ph-VO-Xa-VO-Ph1-
Z、R-Ph-VO-Xa-VO-Ph3-Z、R-Ph-VO-Xa-T-Ph-Z、R-Ph-VO
-Xa-T-Ph1-Z、R-Ph-VO-Xa-T-Ph3-Z、R-Ph-VO-Xa-G-Ph-
Z、R-Ph-VO-Xa-G-Ph1-Z、R-Ph-VO-Xa-G-Ph3-Z、R-Ph-VO
-Xa-J-Ph-Z、R-Ph-VO-Xa-J-Ph1-Z、R-Ph-VO-Xa-J-Ph3-
Z、R-Ph-2-Xa-Ph-Z、R-Ph-2-Xa-Ph1-Z、R-Ph-2-Xa-Ph3-
Z、R-Ph-2-Xa-VO-Ph-Z、R-Ph-2-Xa-VO-Ph1-Z、R-Ph-2-X
a-VO-Ph3-Z、R-Ph-2-Xa-T-Ph-Z、R-Ph-2-Xa-T-Ph1-Z、R
-Ph-2-Xa-T-Ph3-Z、R-Ph-2-Xa-G-Ph-Z、R-Ph-2-Xa-G-Ph
1-Z、R-Ph-2-Xa-G-Ph3-Z、R-Ph-Xa-Ph-Z, R-Ph-Xa-Ph1-Z, R-Ph-Xa-P
h3-Z, R-Ph-Xa-VO-Ph-Z, R-Ph-Xa-VO-Ph1-Z, R-Ph-Xa-V
O-Ph3-Z, R-Ph-Xa-T-Ph-Z, R-Ph-Xa-T-Ph1-Z, R-Ph-Xa-
T-Ph3-Z, R-Ph-Xa-G-Ph-Z, R-Ph-Xa-G-Ph1-Z, R-Ph-Xa-
G-Ph3-Z, R-Ph-Xa-J-Ph-Z, R-Ph-Xa-J-Ph1-Z, R-Ph-Xa-
J-Ph3-Z, R-Ph-VO-Xa-Ph-Z, R-Ph-VO-Xa-Ph1-Z, R-Ph-V
O-Xa-Ph3-Z, R-Ph-VO-Xa-VO-Ph-Z, R-Ph-VO-Xa-VO-Ph1-
Z, R-Ph-VO-Xa-VO-Ph3-Z, R-Ph-VO-Xa-T-Ph-Z, R-Ph-VO
-Xa-T-Ph1-Z, R-Ph-VO-Xa-T-Ph3-Z, R-Ph-VO-Xa-G-Ph-
Z, R-Ph-VO-Xa-G-Ph1-Z, R-Ph-VO-Xa-G-Ph3-Z, R-Ph-VO
-Xa-J-Ph-Z, R-Ph-VO-Xa-J-Ph1-Z, R-Ph-VO-Xa-J-Ph3-
Z, R-Ph-2-Xa-Ph-Z, R-Ph-2-Xa-Ph1-Z, R-Ph-2-Xa-Ph3-
Z, R-Ph-2-Xa-VO-Ph-Z, R-Ph-2-Xa-VO-Ph1-Z, R-Ph-2-X
a-VO-Ph3-Z, R-Ph-2-Xa-T-Ph-Z, R-Ph-2-Xa-T-Ph1-Z, R
-Ph-2-Xa-T-Ph3-Z, R-Ph-2-Xa-G-Ph-Z, R-Ph-2-Xa-G-Ph
1-Z, R-Ph-2-Xa-G-Ph3-Z,

【００２１】R-Ph-2-Xa-J-Ph-Z、R-Ph-2-Xa-J-Ph1-Z、R
-Ph-2-Xa-J-Ph3-Z、R-Ph-G-Xa-Ph-Z、R-Ph-G-Xa-Ph1-
Z、R-Ph-G-Xa-Ph3-Z、R-Ph-G-Xa-VO-Ph-Z、R-Ph-G-Xa-V
O-Ph1-Z、R-Ph-G-Xa-VO-Ph3-Z、R-Ph-G-Xa-T-Ph-Z、R-P
h-G-Xa-T-Ph1-Z、R-Ph-G-Xa-T-Ph3-Z、R-Ph-G-Xa-G-Ph-
Z、R-Ph-G-Xa-G-Ph1-Z、R-Ph-G-Xa-G-Ph3-Z、R-Ph-G-Xa
-J-Ph-Z、R-Ph-G-Xa-J-Ph1-Z、R-Ph-G-Xa-J-Ph3-Z、R-P
h-J-Xa-Ph-Z、R-Ph-J-Xa-Ph1-Z、R-Ph-J-Xa-Ph3-Z、R-P
h-J-Xa-VO-Ph-Z、R-Ph-J-Xa-VO-Ph1-Z、R-Ph-J-Xa-VO-P
h3-Z、R-Ph-J-Xa-T-Ph-Z、R-Ph-J-Xa-T-Ph1-Z、R-Ph-J-
Xa-T-Ph3-Z、R-Ph-J-Xa-G-Ph-Z、R-Ph-J-Xa-G-Ph1-Z、R
-Ph-J-Xa-G-Ph3-Z、R-Ph-J-Xa-J-Ph-Z、R-Ph-J-Xa-J-Ph
1-Z、R-Ph-J-Xa-J-Ph3-Z、R-Ph-Xb-Ph-Z、R-Ph-Xb-Ph1-
Z、R-Ph-Xb-Ph3-Z、R-Ph-Xb-VO-Ph-Z、R-Ph-Xb-VO-Ph1-
Z、R-Ph-Xb-VO-Ph3-Z、R-Ph-Xb-T-Ph-Z、R-Ph-Xb-T-Ph1
-Z、R-Ph-Xb-T-Ph3-Z、R-Ph-Xb-G-Ph-Z、R-Ph-Xb-G-Ph1
-Z、R-Ph-Xb-G-Ph3-Z、R-Ph-Xb-J-Ph-Z、R-Ph-Xb-J-Ph1
-Z、R-Ph-Xb-J-Ph3-Z、R-Ph-VO-Xb-Ph-Z、R-Ph-VO-Xb-P
h1-Z、R-Ph-VO-Xb-Ph3-Z、R-Ph-VO-Xb-VO-Ph-Z、R-Ph-V
O-Xb-VO-Ph1-Z、R-Ph-VO-Xb-VO-Ph3-Z、R-Ph-VO-Xb-T-P
h-Z、R-Ph-VO-Xb-T-Ph1-Z、R-Ph-VO-Xb-T-Ph3-Z、R-Ph-
VO-Xb-G-Ph-Z、R-Ph-VO-Xb-G-Ph1-Z、R-Ph-VO-Xb-G-Ph3
-Z、R-Ph-VO-Xb-J-Ph-Z、R-Ph-VO-Xb-J-Ph1-Z、R-Ph-VO
-Xb-J-Ph3-Z、R-Ph-2-Xb-Ph-Z、R-Ph-2-Xb-Ph1-Z、R-Ph
-2-Xb-Ph3-Z、R-Ph-2-Xb-VO-Ph-Z、R-Ph-2-Xb-VO-Ph1-
Z、R-Ph-2-Xb-VO-Ph3-Z、R-Ph-2-Xb-T-Ph-Z、R-Ph-2-Xb
-T-Ph1-Z、R-Ph-2-Xb-T-Ph3-Z、R-Ph-2-Xb-G-Ph-Z、R-P
h-2-Xb-G-Ph1-Z、R-Ph-2-Xb-G-Ph3-Z、R-Ph-2-Xb-J-Ph-
Z、R-Ph-2-Xb-J-Ph1-Z、R-Ph-2-Xb-J-Ph3-Z、R-Ph-G-Xb
-Ph-Z、R-Ph-G-Xb-Ph1-Z、R-Ph-G-Xb-Ph3-Z、R-Ph-G-Xb
-VO-Ph-Z、R-Ph-G-Xb-VO-Ph1-Z、R-Ph-G-Xb-VO-Ph3-Z、
R-Ph-G-Xb-T-Ph-Z、R-Ph-G-Xb-T-Ph1-Z、R-Ph-G-Xb-T-P
h3-Z、R-Ph-G-Xb-G-Ph-Z、R-Ph-G-Xb-G-Ph1-Z、R-Ph-G-
Xb-G-Ph3-Z、R-Ph-G-Xb-J-Ph-Z、R-Ph-G-Xb-J-Ph1-Z、R
-Ph-G-Xb-J-Ph3-Z、R-Ph-J-Xb-Ph-Z、R-Ph-J-Xb-Ph1-
Z、R-Ph-J-Xb-Ph3-Z、R-Ph-J-Xb-VO-Ph-Z、R-Ph-J-Xb-V
O-Ph1-Z、R-Ph-J-Xb-VO-Ph3-Z、R-Ph-J-Xb-T-Ph-Z、R-P
h-J-Xb-T-Ph1-Z、R-Ph-J-Xb-T-Ph3-Z、R-Ph-J-Xb-G-Ph-
Z、R-Ph-J-Xb-G-Ph1-Z、R-Ph-J-Xb-G-Ph3-Z、R-Ph-J-Xb
-J-Ph-Z、R-Ph-J-Xb-J-Ph1-Z、R-Ph-J-Xb-J-Ph3-ZR-Ph-2-Xa-J-Ph-Z, R-Ph-2-Xa-J-Ph1-Z, R
-Ph-2-Xa-J-Ph3-Z, R-Ph-G-Xa-Ph-Z, R-Ph-G-Xa-Ph1-
Z, R-Ph-G-Xa-Ph3-Z, R-Ph-G-Xa-VO-Ph-Z, R-Ph-G-Xa-V
O-Ph1-Z, R-Ph-G-Xa-VO-Ph3-Z, R-Ph-G-Xa-T-Ph-Z, RP
hG-Xa-T-Ph1-Z, R-Ph-G-Xa-T-Ph3-Z, R-Ph-G-Xa-G-Ph-
Z, R-Ph-G-Xa-G-Ph1-Z, R-Ph-G-Xa-G-Ph3-Z, R-Ph-G-Xa
-J-Ph-Z, R-Ph-G-Xa-J-Ph1-Z, R-Ph-G-Xa-J-Ph3-Z, RP
hJ-Xa-Ph-Z, R-Ph-J-Xa-Ph1-Z, R-Ph-J-Xa-Ph3-Z, RP
hJ-Xa-VO-Ph-Z, R-Ph-J-Xa-VO-Ph1-Z, R-Ph-J-Xa-VO-P
h3-Z, R-Ph-J-Xa-T-Ph-Z, R-Ph-J-Xa-T-Ph1-Z, R-Ph-J-
Xa-T-Ph3-Z, R-Ph-J-Xa-G-Ph-Z, R-Ph-J-Xa-G-Ph1-Z, R
-Ph-J-Xa-G-Ph3-Z, R-Ph-J-Xa-J-Ph-Z, R-Ph-J-Xa-J-Ph
1-Z, R-Ph-J-Xa-J-Ph3-Z, R-Ph-Xb-Ph-Z, R-Ph-Xb-Ph1-
Z, R-Ph-Xb-Ph3-Z, R-Ph-Xb-VO-Ph-Z, R-Ph-Xb-VO-Ph1-
Z, R-Ph-Xb-VO-Ph3-Z, R-Ph-Xb-T-Ph-Z, R-Ph-Xb-T-Ph1
-Z, R-Ph-Xb-T-Ph3-Z, R-Ph-Xb-G-Ph-Z, R-Ph-Xb-G-Ph1
-Z, R-Ph-Xb-G-Ph3-Z, R-Ph-Xb-J-Ph-Z, R-Ph-Xb-J-Ph1
-Z, R-Ph-Xb-J-Ph3-Z, R-Ph-VO-Xb-Ph-Z, R-Ph-VO-Xb-P
h1-Z, R-Ph-VO-Xb-Ph3-Z, R-Ph-VO-Xb-VO-Ph-Z, R-Ph-V
O-Xb-VO-Ph1-Z, R-Ph-VO-Xb-VO-Ph3-Z, R-Ph-VO-Xb-TP
hZ, R-Ph-VO-Xb-T-Ph1-Z, R-Ph-VO-Xb-T-Ph3-Z, R-Ph-
VO-Xb-G-Ph-Z, R-Ph-VO-Xb-G-Ph1-Z, R-Ph-VO-Xb-G-Ph3
-Z, R-Ph-VO-Xb-J-Ph-Z, R-Ph-VO-Xb-J-Ph1-Z, R-Ph-VO
-Xb-J-Ph3-Z, R-Ph-2-Xb-Ph-Z, R-Ph-2-Xb-Ph1-Z, R-Ph
-2-Xb-Ph3-Z, R-Ph-2-Xb-VO-Ph-Z, R-Ph-2-Xb-VO-Ph1-
Z, R-Ph-2-Xb-VO-Ph3-Z, R-Ph-2-Xb-T-Ph-Z, R-Ph-2-Xb
-T-Ph1-Z, R-Ph-2-Xb-T-Ph3-Z, R-Ph-2-Xb-G-Ph-Z, RP
h-2-Xb-G-Ph1-Z, R-Ph-2-Xb-G-Ph3-Z, R-Ph-2-Xb-J-Ph-
Z, R-Ph-2-Xb-J-Ph1-Z, R-Ph-2-Xb-J-Ph3-Z, R-Ph-G-Xb
-Ph-Z, R-Ph-G-Xb-Ph1-Z, R-Ph-G-Xb-Ph3-Z, R-Ph-G-Xb
-VO-Ph-Z, R-Ph-G-Xb-VO-Ph1-Z, R-Ph-G-Xb-VO-Ph3-Z,
R-Ph-G-Xb-T-Ph-Z, R-Ph-G-Xb-T-Ph1-Z, R-Ph-G-Xb-TP
h3-Z, R-Ph-G-Xb-G-Ph-Z, R-Ph-G-Xb-G-Ph1-Z, R-Ph-G-
Xb-G-Ph3-Z, R-Ph-G-Xb-J-Ph-Z, R-Ph-G-Xb-J-Ph1-Z, R
-Ph-G-Xb-J-Ph3-Z, R-Ph-J-Xb-Ph-Z, R-Ph-J-Xb-Ph1-
Z, R-Ph-J-Xb-Ph3-Z, R-Ph-J-Xb-VO-Ph-Z, R-Ph-J-Xb-V
O-Ph1-Z, R-Ph-J-Xb-VO-Ph3-Z, R-Ph-J-Xb-T-Ph-Z, RP
hJ-Xb-T-Ph1-Z, R-Ph-J-Xb-T-Ph3-Z, R-Ph-J-Xb-G-Ph-
Z, R-Ph-J-Xb-G-Ph1-Z, R-Ph-J-Xb-G-Ph3-Z, R-Ph-J-Xb
-J-Ph-Z, R-Ph-J-Xb-J-Ph1-Z, R-Ph-J-Xb-J-Ph3-Z

【００２２】R-Ph1-Xa-Ph-Z、R-Ph1-Xa-Ph1-Z、R-Ph1-X
a-Ph3-Z、R-Ph1-Xa-VO-Ph-Z、R-Ph1-Xa-VO-Ph1-Z、R-Ph
1-Xa-VO-Ph3-Z、R-Ph1-Xa-T-Ph-Z、R-Ph1-Xa-T-Ph1-Z、
R-Ph1-Xa-T-Ph3-Z、R-Ph1-Xa-G-Ph-Z、R-Ph1-Xa-G-Ph1-
Z、R-Ph1-Xa-G-Ph3-Z、R-Ph1-Xa-J-Ph-Z、R-Ph1-Xa-J-P
h1-Z、R-Ph1-Xa-J-Ph3-Z、R-Ph1-VO-Xa-Ph-Z、R-Ph1-VO
-Xa-Ph1-Z、R-Ph1-VO-Xa-Ph3-Z、R-Ph1-VO-Xa-VO-Ph-
Z、R-Ph1-VO-Xa-VO-Ph1-Z、R-Ph1-VO-Xa-VO-Ph3-Z、R-P
h1-VO-Xa-T-Ph-Z、R-Ph1-VO-Xa-T-Ph1-Z、R-Ph1-VO-Xa-
T-Ph3-Z、R-Ph1-VO-Xa-G-Ph-Z、R-Ph1-VO-Xa-G-Ph1-Z、
R-Ph1-VO-Xa-G-Ph3-Z、R-Ph1-VO-Xa-J-Ph-Z、R-Ph1-VO-
Xa-J-Ph1-Z、R-Ph1-VO-Xa-J-Ph3-Z、R-Ph1-2-Xa-Ph-Z、
R-Ph1-2-Xa-Ph1-Z、R-Ph1-2-Xa-Ph3-Z、R-Ph1-2-Xa-VO-
Ph-Z、R-Ph1-2-Xa-VO-Ph1-Z、R-Ph1-2-Xa-VO-Ph3-Z、R-
Ph1-2-Xa-T-Ph-Z、R-Ph1-2-Xa-T-Ph1-Z、R-Ph1-2-Xa-T-
Ph3-Z、R-Ph1-2-Xa-G-Ph-Z、R-Ph1-2-Xa-G-Ph1-Z、R-Ph
1-2-Xa-G-Ph3-Z、R-Ph1-2-Xa-J-Ph-Z、R-Ph1-2-Xa-J-Ph
1-Z、R-Ph1-2-Xa-J-Ph3-Z、R-Ph1-G-Xa-Ph-Z、R-Ph1-G-
Xa-Ph1-Z、R-Ph1-G-Xa-Ph3-Z、R-Ph1-G-Xa-VO-Ph-Z、R-
Ph1-G-Xa-VO-Ph1-Z、R-Ph1-G-Xa-VO-Ph3-Z、R-Ph1-G-Xa
-T-Ph-Z、R-Ph1-G-Xa-T-Ph1-Z、R-Ph1-G-Xa-T-Ph3-Z、R
-Ph1-G-Xa-G-Ph-Z、R-Ph1-G-Xa-G-Ph1-Z、R-Ph1-G-Xa-G
-Ph3-Z、R-Ph1-G-Xa-J-Ph-Z、R-Ph1-G-Xa-J-Ph1-Z、R-P
h1-G-Xa-J-Ph3-Z、R-Ph1-J-Xa-Ph-Z、R-Ph1-J-Xa-Ph1-
Z、R-Ph1-J-Xa-Ph3-Z、R-Ph1-J-Xa-VO-Ph-Z、R-Ph1-J-X
a-VO-Ph1-Z、R-Ph1-J-Xa-VO-Ph3-Z、R-Ph1-J-Xa-T-Ph-
Z、R-Ph1-J-Xa-T-Ph1-Z、R-Ph1-J-Xa-T-Ph3-Z、R-Ph1-J
-Xa-G-Ph-Z、R-Ph1-J-Xa-G-Ph1-Z、R-Ph1-J-Xa-G-Ph3-
Z、R-Ph1-J-Xa-J-Ph-Z、R-Ph1-J-Xa-J-Ph1-Z、R-Ph1-J-
Xa-J-Ph3-Z、R-Ph1-Xb-Ph-Z、R-Ph1-Xb-Ph1-Z、R-Ph1-X
b-Ph3-Z、R-Ph1-Xb-VO-Ph-Z、R-Ph1-Xb-VO-Ph1-Z、R-Ph
1-Xb-VO-Ph3-Z、R-Ph1-Xb-T-Ph-Z、R-Ph1-Xb-T-Ph1-Z、
R-Ph1-Xb-T-Ph3-Z、R-Ph1-Xb-G-Ph-Z、R-Ph1-Xb-G-Ph1-
Z、R-Ph1-Xb-G-Ph3-Z、R-Ph1-Xb-J-Ph-Z、R-Ph1-Xb-J-P
h1-Z、R-Ph1-Xb-J-Ph3-Z、R-Ph1-VO-Xb-Ph-Z、R-Ph1-VO
-Xb-Ph1-Z、R-Ph1-VO-Xb-Ph3-Z、R-Ph1-VO-Xb-VO-Ph-
Z、R-Ph1-VO-Xb-VO-Ph1-Z、R-Ph1-VO-Xb-VO-Ph3-Z、R-P
h1-VO-Xb-T-Ph-Z、R-Ph1-VO-Xb-T-Ph1-Z、R-Ph1-VO-Xb-
T-Ph3-Z、R-Ph1-VO-Xb-G-Ph-Z、R-Ph1-VO-Xb-G-Ph1-Z、
R-Ph1-VO-Xb-G-Ph3-Z、R-Ph1-VO-Xb-J-Ph-Z、R-Ph1-VO-
Xb-J-Ph1-Z、R-Ph1-VO-Xb-J-Ph3-Z、R-Ph1-2-Xb-Ph-Z、
R-Ph1-2-Xb-Ph1-Z、R-Ph1-2-Xb-Ph3-Z、R-Ph1-2-Xb-VO-
Ph-Z、R-Ph1-2-Xb-VO-Ph1-Z、R-Ph1-2-Xb-VO-Ph3-Z、R-
Ph1-2-Xb-T-Ph-Z、R-Ph1-2-Xb-T-Ph1-Z、R-Ph1-2-Xb-T-
Ph3-Z、R-Ph1-2-Xb-G-Ph-Z、R-Ph1-2-Xb-G-Ph1-Z、R-Ph
1-2-Xb-G-Ph3-Z、R-Ph1-2-Xb-J-Ph-Z、R-Ph1-2-Xb-J-Ph
1-Z、R-Ph1-2-Xb-J-Ph3-Z、R-Ph1-G-Xb-Ph-Z、R-Ph1-G-
Xb-Ph1-Z、R-Ph1-G-Xb-Ph3-Z、R-Ph1-G-Xb-VO-Ph-Z、R-
Ph1-G-Xb-VO-Ph1-Z、R-Ph1-G-Xb-VO-Ph3-Z、R-Ph1-G-Xb
-T-Ph-Z、R-Ph1-G-Xb-T-Ph1-Z、R-Ph1-G-Xb-T-Ph3-Z、R
-Ph1-G-Xb-G-Ph-Z、R-Ph1-G-Xb-G-Ph1-Z、R-Ph1-G-Xb-G
-Ph3-Z、R-Ph1-G-Xb-J-Ph-Z、R-Ph1-G-Xb-J-Ph1-Z、R-P
h1-G-Xb-J-Ph3-Z、R-Ph1-J-Xb-Ph-Z、R-Ph1-J-Xb-Ph1-
Z、R-Ph1-J-Xb-Ph3-Z、R-Ph1-J-Xb-VO-Ph-Z、R-Ph1-J-X
b-VO-Ph1-Z、R-Ph1-J-Xb-VO-Ph3-Z、R-Ph1-J-Xb-T-Ph-
Z、R-Ph1-J-Xb-T-Ph1-Z、R-Ph1-J-Xb-T-Ph3-Z、R-Ph1-J
-Xb-G-Ph-Z、R-Ph1-J-Xb-G-Ph1-Z、R-Ph1-J-Xb-G-Ph3-
Z、R-Ph1-J-Xb-J-Ph-Z、R-Ph1-J-Xb-J-Ph1-Z、R-Ph1-J-
Xb-J-Ph3-Z R-Ph3-Xa-Ph-Z、R-Ph3-Xa-Ph1-Z、R-Ph3-Xa-Ph3-Z、R-P
h3-Xa-VO-Ph-Z、R-Ph3-Xa-VO-Ph1-Z、R-Ph3-Xa-VO-Ph3-
Z、R-Ph3-Xa-T-Ph-Z、R-Ph3-Xa-T-Ph1-Z、R-Ph3-Xa-T-P
h3-Z、R-Ph3-Xa-G-Ph-Z、R-Ph3-Xa-G-Ph1-Z、R-Ph3-Xa-
G-Ph3-Z、R-Ph3-Xa-J-Ph-Z、R-Ph3-Xa-J-Ph1-Z、R-Ph3-
Xa-J-Ph3-Z、R-Ph3-VO-Xa-Ph-Z、R-Ph3-VO-Xa-Ph1-Z、R
-Ph3-VO-Xa-Ph3-Z、R-Ph3-VO-Xa-VO-Ph-Z、R-Ph3-VO-Xa
-VO-Ph1-Z、R-Ph3-VO-Xa-VO-Ph3-Z、R-Ph3-VO-Xa-T-Ph-
Z、R-Ph3-VO-Xa-T-Ph1-Z、R-Ph3-VO-Xa-T-Ph3-Z、R-Ph3
-VO-Xa-G-Ph-Z、R-Ph3-VO-Xa-G-Ph1-Z、R-Ph3-VO-Xa-G-
Ph3-Z、R-Ph3-VO-Xa-J-Ph-Z、R-Ph3-VO-Xa-J-Ph1-Z、R-
Ph3-VO-Xa-J-Ph3-Z、R-Ph3-2-Xa-Ph-Z、R-Ph3-2-Xa-Ph1
-Z、R-Ph3-2-Xa-Ph3-Z、R-Ph3-2-Xa-VO-Ph-Z、R-Ph3-2-
Xa-VO-Ph1-Z、R-Ph3-2-Xa-VO-Ph3-Z、R-Ph3-2-Xa-T-Ph-
Z、R-Ph3-2-Xa-T-Ph1-Z、R-Ph3-2-Xa-T-Ph3-Z、R-Ph3-2
-Xa-G-Ph-Z、R-Ph3-2-Xa-G-Ph1-Z、R-Ph3-2-Xa-G-Ph3-
Z、R-Ph3-2-Xa-J-Ph-Z、R-Ph3-2-Xa-J-Ph1-Z、R-Ph3-2-
Xa-J-Ph3-Z、R-Ph3-G-Xa-Ph-Z、R-Ph3-G-Xa-Ph1-Z、R-P
h3-G-Xa-Ph3-Z、R-Ph3-G-Xa-VO-Ph-Z、R-Ph3-G-Xa-VO-P
h1-Z、R-Ph3-G-Xa-VO-Ph3-Z、R-Ph3-G-Xa-T-Ph-Z、R-Ph
3-G-Xa-T-Ph1-Z、R-Ph3-G-Xa-T-Ph3-Z、R-Ph3-G-Xa-G-P
h-Z、R-Ph3-G-Xa-G-Ph1-Z、R-Ph3-G-Xa-G-Ph3-Z、R-Ph3
-G-Xa-J-Ph-Z、R-Ph3-G-Xa-J-Ph1-Z、R-Ph3-G-Xa-J-Ph3
-Z、R-Ph3-J-Xa-Ph-Z、R-Ph3-J-Xa-Ph1-Z、R-Ph3-J-Xa-
Ph3-Z、R-Ph3-J-Xa-VO-Ph-Z、R-Ph3-J-Xa-VO-Ph1-Z、R-
Ph3-J-Xa-VO-Ph3-Z、R-Ph3-J-Xa-T-Ph-Z、R-Ph3-J-Xa-T
-Ph1-Z、R-Ph3-J-Xa-T-Ph3-Z、R-Ph3-J-Xa-G-Ph-Z、R-P
h3-J-Xa-G-Ph-1-Z、R-Ph1-Xa-Ph-Z, R-Ph1-Xa-Ph1-Z, R-Ph1-X
a-Ph3-Z, R-Ph1-Xa-VO-Ph-Z, R-Ph1-Xa-VO-Ph1-Z, R-Ph
1-Xa-VO-Ph3-Z, R-Ph1-Xa-T-Ph-Z, R-Ph1-Xa-T-Ph1-Z,
R-Ph1-Xa-T-Ph3-Z, R-Ph1-Xa-G-Ph-Z, R-Ph1-Xa-G-Ph1-
Z, R-Ph1-Xa-G-Ph3-Z, R-Ph1-Xa-J-Ph-Z, R-Ph1-Xa-JP
h1-Z, R-Ph1-Xa-J-Ph3-Z, R-Ph1-VO-Xa-Ph-Z, R-Ph1-VO
-Xa-Ph1-Z, R-Ph1-VO-Xa-Ph3-Z, R-Ph1-VO-Xa-VO-Ph-
Z, R-Ph1-VO-Xa-VO-Ph1-Z, R-Ph1-VO-Xa-VO-Ph3-Z, RP
h1-VO-Xa-T-Ph-Z, R-Ph1-VO-Xa-T-Ph1-Z, R-Ph1-VO-Xa-
T-Ph3-Z, R-Ph1-VO-Xa-G-Ph-Z, R-Ph1-VO-Xa-G-Ph1-Z,
R-Ph1-VO-Xa-G-Ph3-Z, R-Ph1-VO-Xa-J-Ph-Z, R-Ph1-VO-
Xa-J-Ph1-Z, R-Ph1-VO-Xa-J-Ph3-Z, R-Ph1-2-Xa-Ph-Z,
R-Ph1-2-Xa-Ph1-Z, R-Ph1-2-Xa-Ph3-Z, R-Ph1-2-Xa-VO-
Ph-Z, R-Ph1-2-Xa-VO-Ph1-Z, R-Ph1-2-Xa-VO-Ph3-Z, R-
Ph1-2-Xa-T-Ph-Z, R-Ph1-2-Xa-T-Ph1-Z, R-Ph1-2-Xa-T-
Ph3-Z, R-Ph1-2-Xa-G-Ph-Z, R-Ph1-2-Xa-G-Ph1-Z, R-Ph
1-2-Xa-G-Ph3-Z, R-Ph1-2-Xa-J-Ph-Z, R-Ph1-2-Xa-J-Ph
1-Z, R-Ph1-2-Xa-J-Ph3-Z, R-Ph1-G-Xa-Ph-Z, R-Ph1-G-
Xa-Ph1-Z, R-Ph1-G-Xa-Ph3-Z, R-Ph1-G-Xa-VO-Ph-Z, R-
Ph1-G-Xa-VO-Ph1-Z, R-Ph1-G-Xa-VO-Ph3-Z, R-Ph1-G-Xa
-T-Ph-Z, R-Ph1-G-Xa-T-Ph1-Z, R-Ph1-G-Xa-T-Ph3-Z, R
-Ph1-G-Xa-G-Ph-Z, R-Ph1-G-Xa-G-Ph1-Z, R-Ph1-G-Xa-G
-Ph3-Z, R-Ph1-G-Xa-J-Ph-Z, R-Ph1-G-Xa-J-Ph1-Z, RP
h1-G-Xa-J-Ph3-Z, R-Ph1-J-Xa-Ph-Z, R-Ph1-J-Xa-Ph1-
Z, R-Ph1-J-Xa-Ph3-Z, R-Ph1-J-Xa-VO-Ph-Z, R-Ph1-JX
a-VO-Ph1-Z, R-Ph1-J-Xa-VO-Ph3-Z, R-Ph1-J-Xa-T-Ph-
Z, R-Ph1-J-Xa-T-Ph1-Z, R-Ph1-J-Xa-T-Ph3-Z, R-Ph1-J
-Xa-G-Ph-Z, R-Ph1-J-Xa-G-Ph1-Z, R-Ph1-J-Xa-G-Ph3-
Z, R-Ph1-J-Xa-J-Ph-Z, R-Ph1-J-Xa-J-Ph1-Z, R-Ph1-J-
Xa-J-Ph3-Z, R-Ph1-Xb-Ph-Z, R-Ph1-Xb-Ph1-Z, R-Ph1-X
b-Ph3-Z, R-Ph1-Xb-VO-Ph-Z, R-Ph1-Xb-VO-Ph1-Z, R-Ph
1-Xb-VO-Ph3-Z, R-Ph1-Xb-T-Ph-Z, R-Ph1-Xb-T-Ph1-Z,
R-Ph1-Xb-T-Ph3-Z, R-Ph1-Xb-G-Ph-Z, R-Ph1-Xb-G-Ph1-
Z, R-Ph1-Xb-G-Ph3-Z, R-Ph1-Xb-J-Ph-Z, R-Ph1-Xb-JP
h1-Z, R-Ph1-Xb-J-Ph3-Z, R-Ph1-VO-Xb-Ph-Z, R-Ph1-VO
-Xb-Ph1-Z, R-Ph1-VO-Xb-Ph3-Z, R-Ph1-VO-Xb-VO-Ph-
Z, R-Ph1-VO-Xb-VO-Ph1-Z, R-Ph1-VO-Xb-VO-Ph3-Z, RP
h1-VO-Xb-T-Ph-Z, R-Ph1-VO-Xb-T-Ph1-Z, R-Ph1-VO-Xb-
T-Ph3-Z, R-Ph1-VO-Xb-G-Ph-Z, R-Ph1-VO-Xb-G-Ph1-Z,
R-Ph1-VO-Xb-G-Ph3-Z, R-Ph1-VO-Xb-J-Ph-Z, R-Ph1-VO-
Xb-J-Ph1-Z, R-Ph1-VO-Xb-J-Ph3-Z, R-Ph1-2-Xb-Ph-Z,
R-Ph1-2-Xb-Ph1-Z, R-Ph1-2-Xb-Ph3-Z, R-Ph1-2-Xb-VO-
Ph-Z, R-Ph1-2-Xb-VO-Ph1-Z, R-Ph1-2-Xb-VO-Ph3-Z, R-
Ph1-2-Xb-T-Ph-Z, R-Ph1-2-Xb-T-Ph1-Z, R-Ph1-2-Xb-T-
Ph3-Z, R-Ph1-2-Xb-G-Ph-Z, R-Ph1-2-Xb-G-Ph1-Z, R-Ph
1-2-Xb-G-Ph3-Z, R-Ph1-2-Xb-J-Ph-Z, R-Ph1-2-Xb-J-Ph
1-Z, R-Ph1-2-Xb-J-Ph3-Z, R-Ph1-G-Xb-Ph-Z, R-Ph1-G-
Xb-Ph1-Z, R-Ph1-G-Xb-Ph3-Z, R-Ph1-G-Xb-VO-Ph-Z, R-
Ph1-G-Xb-VO-Ph1-Z, R-Ph1-G-Xb-VO-Ph3-Z, R-Ph1-G-Xb
-T-Ph-Z, R-Ph1-G-Xb-T-Ph1-Z, R-Ph1-G-Xb-T-Ph3-Z, R
-Ph1-G-Xb-G-Ph-Z, R-Ph1-G-Xb-G-Ph1-Z, R-Ph1-G-Xb-G
-Ph3-Z, R-Ph1-G-Xb-J-Ph-Z, R-Ph1-G-Xb-J-Ph1-Z, RP
h1-G-Xb-J-Ph3-Z, R-Ph1-J-Xb-Ph-Z, R-Ph1-J-Xb-Ph1-
Z, R-Ph1-J-Xb-Ph3-Z, R-Ph1-J-Xb-VO-Ph-Z, R-Ph1-JX
b-VO-Ph1-Z, R-Ph1-J-Xb-VO-Ph3-Z, R-Ph1-J-Xb-T-Ph-
Z, R-Ph1-J-Xb-T-Ph1-Z, R-Ph1-J-Xb-T-Ph3-Z, R-Ph1-J
-Xb-G-Ph-Z, R-Ph1-J-Xb-G-Ph1-Z, R-Ph1-J-Xb-G-Ph3-
Z, R-Ph1-J-Xb-J-Ph-Z, R-Ph1-J-Xb-J-Ph1-Z, R-Ph1-J-
Xb-J-Ph3-Z R-Ph3-Xa-Ph-Z, R-Ph3-Xa-Ph1-Z, R-Ph3-Xa-Ph3-Z, RP
h3-Xa-VO-Ph-Z, R-Ph3-Xa-VO-Ph1-Z, R-Ph3-Xa-VO-Ph3-
Z, R-Ph3-Xa-T-Ph-Z, R-Ph3-Xa-T-Ph1-Z, R-Ph3-Xa-TP
h3-Z, R-Ph3-Xa-G-Ph-Z, R-Ph3-Xa-G-Ph1-Z, R-Ph3-Xa-
G-Ph3-Z, R-Ph3-Xa-J-Ph-Z, R-Ph3-Xa-J-Ph1-Z, R-Ph3-
Xa-J-Ph3-Z, R-Ph3-VO-Xa-Ph-Z, R-Ph3-VO-Xa-Ph1-Z, R
-Ph3-VO-Xa-Ph3-Z, R-Ph3-VO-Xa-VO-Ph-Z, R-Ph3-VO-Xa
-VO-Ph1-Z, R-Ph3-VO-Xa-VO-Ph3-Z, R-Ph3-VO-Xa-T-Ph-
Z, R-Ph3-VO-Xa-T-Ph1-Z, R-Ph3-VO-Xa-T-Ph3-Z, R-Ph3
-VO-Xa-G-Ph-Z, R-Ph3-VO-Xa-G-Ph1-Z, R-Ph3-VO-Xa-G-
Ph3-Z, R-Ph3-VO-Xa-J-Ph-Z, R-Ph3-VO-Xa-J-Ph1-Z, R-
Ph3-VO-Xa-J-Ph3-Z, R-Ph3-2-Xa-Ph-Z, R-Ph3-2-Xa-Ph1
-Z, R-Ph3-2-Xa-Ph3-Z, R-Ph3-2-Xa-VO-Ph-Z, R-Ph3-2-
Xa-VO-Ph1-Z, R-Ph3-2-Xa-VO-Ph3-Z, R-Ph3-2-Xa-T-Ph-
Z, R-Ph3-2-Xa-T-Ph1-Z, R-Ph3-2-Xa-T-Ph3-Z, R-Ph3-2
-Xa-G-Ph-Z, R-Ph3-2-Xa-G-Ph1-Z, R-Ph3-2-Xa-G-Ph3-
Z, R-Ph3-2-Xa-J-Ph-Z, R-Ph3-2-Xa-J-Ph1-Z, R-Ph3-2-
Xa-J-Ph3-Z, R-Ph3-G-Xa-Ph-Z, R-Ph3-G-Xa-Ph1-Z, RP
h3-G-Xa-Ph3-Z, R-Ph3-G-Xa-VO-Ph-Z, R-Ph3-G-Xa-VO-P
h1-Z, R-Ph3-G-Xa-VO-Ph3-Z, R-Ph3-G-Xa-T-Ph-Z, R-Ph
3-G-Xa-T-Ph1-Z, R-Ph3-G-Xa-T-Ph3-Z, R-Ph3-G-Xa-GP
hZ, R-Ph3-G-Xa-G-Ph1-Z, R-Ph3-G-Xa-G-Ph3-Z, R-Ph3
-G-Xa-J-Ph-Z, R-Ph3-G-Xa-J-Ph1-Z, R-Ph3-G-Xa-J-Ph3
-Z, R-Ph3-J-Xa-Ph-Z, R-Ph3-J-Xa-Ph1-Z, R-Ph3-J-Xa-
Ph3-Z, R-Ph3-J-Xa-VO-Ph-Z, R-Ph3-J-Xa-VO-Ph1-Z, R-
Ph3-J-Xa-VO-Ph3-Z, R-Ph3-J-Xa-T-Ph-Z, R-Ph3-J-Xa-T
-Ph1-Z, R-Ph3-J-Xa-T-Ph3-Z, R-Ph3-J-Xa-G-Ph-Z, RP
h3-J-Xa-G-Ph-1-Z,

【００２３】R-Ph3-J-Xa-G-Ph3-Z、R-Ph3-J-Xa-J-Ph-
Z、R-Ph3-J-Xa-J-Ph1-Z、R-Ph3-J-Xa-J-Ph3-Z、R-Ph3-X
b-Ph-Z、R-Ph3-Xb-Ph1-Z、R-Ph3-Xb-Ph3-Z、R-Ph3-Xb-V
O-Ph-Z、R-Ph3-Xb-VO-Ph1-Z、R-Ph3-Xb-VO-Ph3-Z、R-Ph
3-Xb-T-Ph-Z、R-Ph3-Xb-T-Ph1-Z、R-Ph3-Xb-T-Ph3-Z、R
-Ph3-Xb-G-Ph-Z、R-Ph3-Xb-G-Ph1-Z、R-Ph3-Xb-G-Ph3-
Z、R-Ph3-Xb-J-Ph-Z、R-Ph3-Xb-J-Ph1-Z、R-Ph3-Xb-J-P
h3-Z、R-Ph3-VO-Xb-Ph-Z、R-Ph3-VO-Xb-Ph1-Z、R-Ph3-V
O-Xb-Ph3-Z、R-Ph3-VO-Xb-VO-Ph-Z、R-Ph3-VO-Xb-VO-Ph
1-Z、R-Ph3-VO-Xb-VO-Ph3-Z、R-Ph3-VO-Xb-T-Ph-Z、R-P
h3-VO-Xb-T-Ph1-Z、R-Ph3-VO-Xb-T-Ph3-Z、R-Ph3-VO-Xb
-G-Ph-Z、R-Ph3-VO-Xb-G-Ph1-Z、R-Ph3-VO-Xb-G-Ph3-
Z、R-Ph3-VO-Xb-J-Ph-Z、R-Ph3-VO-Xb-J-Ph1-Z、R-Ph3-
VO-Xb-J-Ph3-Z、R-Ph3-2-Xb-Ph-Z、R-Ph3-2-Xb-Ph1-Z、
R-Ph3-2-Xb-Ph3-Z、R-Ph3-2-Xb-VO-Ph-Z、R-Ph3-2-Xb-V
O-Ph1-Z、R-Ph3-2-Xb-VO-Ph3-Z、R-Ph3-2-Xb-T-Ph-Z、R
-Ph3-2-Xb-T-Ph1-Z、R-Ph3-2-Xb-T-Ph3-Z、R-Ph3-2-Xb-
G-Ph-Z、R-Ph3-2-Xb-G-Ph1-Z、R-Ph3-2-Xb-G-Ph3-Z、R-
Ph3-2-Xb-J-Ph-Z、R-Ph3-2-Xb-J-Ph1-Z、R-Ph3-2-Xb-J-
Ph3-Z、R-Ph3-G-Xb-Ph-Z、R-Ph3-G-Xb-Ph1-Z、R-Ph3-G-
Xb-Ph3-Z、R-Ph3-G-Xb-VO-Ph-Z、R-Ph3-G-Xb-VO-Ph1-
Z、R-Ph3-G-Xb-VO-Ph3-Z、R-Ph3-G-Xb-T-Ph-Z、R-Ph3-G
-Xb-T-Ph1-Z、R-Ph3-G-Xb-T-Ph3-Z、R-Ph3-G-Xb-G-Ph-
Z、R-Ph3-G-Xb-G-Ph1-Z、R-Ph3-G-Xb-G-Ph3-Z、R-Ph3-G
-Xb-J-Ph-Z、R-Ph3-G-Xb-J-Ph1-Z、R-Ph3-G-Xb-J-Ph3-
Z、R-Ph3-J-Xb-Ph-Z、R-Ph3-J-Xb-Ph1-Z、R-Ph3-J-Xb-P
h3-Z、R-Ph3-J-Xb-VO-Ph-Z、R-Ph3-J-Xb-VO-Ph1-Z、R-P
h3-J-Xb-VO-Ph3-Z、R-Ph3-J-Xb-T-Ph-Z、R-Ph3-J-Xb-T-
Ph1-Z、R-Ph3-J-Xb-T-Ph3-Z、R-Ph3-J-Xb-G-Ph-Z、R-Ph
3-J-Xb-G-Ph1-Z、R-Ph3-J-Xb-G-Ph3-Z、R-Ph3-J-Xb-J-P
h-Z、R-Ph3-J-Xb-J-Ph1-Z、R-Ph3-J-Xb-J-Ph3-Z、R-Cy-
Cy-Xa-Z、R-Cy-Cy-2-Xa-Z、R-Cy-Cy-VO-Xa-Z、R-Cy-Cy-
T-Xa-Z、R-Cy-Cy-G-Xa-Z、R-Cy-Cy-J-Xa-Z、R-Cy-Cy-K-
Xa-Z、R-Cy-Ph-Xa-Z、R-Cy-Ph-2-Xa-Z、R-Cy-Ph-VO-Xa-
Z、R-Cy-Ph-T-Xa-Z、R-Cy-Ph-G-Xa-Z、R-Cy-Ph-J-Xa-
Z、R-Cy-Ph-K-Xa-Z、R-Cy-Ph1-Xa-Z、R-Cy-Ph1-2-Xa-
Z、R-Cy-Ph1-VO-Xa-Z、R-Cy-Ph1-T-Xa-Z、R-Cy-Ph1-G-X
a-Z、R-Cy-Ph1-J-Xa-Z、R-Cy-Ph1-K-Xa-Z、R-Cy-Ph3-Xa
-Z、R-Cy-Ph3-2-Xa-Z、R-Cy-Ph3-VO-Xa-Z、R-Cy-Ph3-T-
Xa-Z、R-Cy-Ph3-G-Xa-Z、R-Cy-Ph3-J-Xa-Z、R-Cy-Ph3-K
-Xa-Z、R-Cy-Ph3-Xa-Z、R-Cy-Ph3-2-Xa-Z、R-Cy-Ph3-VO
-Xa-Z、R-Cy-Ph3-T-Xa-Z、R-Cy-Ph3-G-Xa-Z、R-Cy-Ph3-
J-Xa-Z、R-Cy-Ph3-K-Xa-Z、R-Ph3-J-Xa-G-Ph3-Z, R-Ph3-J-Xa-J-Ph-
Z, R-Ph3-J-Xa-J-Ph1-Z, R-Ph3-J-Xa-J-Ph3-Z, R-Ph3-X
b-Ph-Z, R-Ph3-Xb-Ph1-Z, R-Ph3-Xb-Ph3-Z, R-Ph3-Xb-V
O-Ph-Z, R-Ph3-Xb-VO-Ph1-Z, R-Ph3-Xb-VO-Ph3-Z, R-Ph
3-Xb-T-Ph-Z, R-Ph3-Xb-T-Ph1-Z, R-Ph3-Xb-T-Ph3-Z, R
-Ph3-Xb-G-Ph-Z, R-Ph3-Xb-G-Ph1-Z, R-Ph3-Xb-G-Ph3-
Z, R-Ph3-Xb-J-Ph-Z, R-Ph3-Xb-J-Ph1-Z, R-Ph3-Xb-JP
h3-Z, R-Ph3-VO-Xb-Ph-Z, R-Ph3-VO-Xb-Ph1-Z, R-Ph3-V
O-Xb-Ph3-Z, R-Ph3-VO-Xb-VO-Ph-Z, R-Ph3-VO-Xb-VO-Ph
1-Z, R-Ph3-VO-Xb-VO-Ph3-Z, R-Ph3-VO-Xb-T-Ph-Z, RP
h3-VO-Xb-T-Ph1-Z, R-Ph3-VO-Xb-T-Ph3-Z, R-Ph3-VO-Xb
-G-Ph-Z, R-Ph3-VO-Xb-G-Ph1-Z, R-Ph3-VO-Xb-G-Ph3-
Z, R-Ph3-VO-Xb-J-Ph-Z, R-Ph3-VO-Xb-J-Ph1-Z, R-Ph3-
VO-Xb-J-Ph3-Z, R-Ph3-2-Xb-Ph-Z, R-Ph3-2-Xb-Ph1-Z,
R-Ph3-2-Xb-Ph3-Z, R-Ph3-2-Xb-VO-Ph-Z, R-Ph3-2-Xb-V
O-Ph1-Z, R-Ph3-2-Xb-VO-Ph3-Z, R-Ph3-2-Xb-T-Ph-Z, R
-Ph3-2-Xb-T-Ph1-Z, R-Ph3-2-Xb-T-Ph3-Z, R-Ph3-2-Xb-
G-Ph-Z, R-Ph3-2-Xb-G-Ph1-Z, R-Ph3-2-Xb-G-Ph3-Z, R-
Ph3-2-Xb-J-Ph-Z, R-Ph3-2-Xb-J-Ph1-Z, R-Ph3-2-Xb-J-
Ph3-Z, R-Ph3-G-Xb-Ph-Z, R-Ph3-G-Xb-Ph1-Z, R-Ph3-G-
Xb-Ph3-Z, R-Ph3-G-Xb-VO-Ph-Z, R-Ph3-G-Xb-VO-Ph1-
Z, R-Ph3-G-Xb-VO-Ph3-Z, R-Ph3-G-Xb-T-Ph-Z, R-Ph3-G
-Xb-T-Ph1-Z, R-Ph3-G-Xb-T-Ph3-Z, R-Ph3-G-Xb-G-Ph-
Z, R-Ph3-G-Xb-G-Ph1-Z, R-Ph3-G-Xb-G-Ph3-Z, R-Ph3-G
-Xb-J-Ph-Z, R-Ph3-G-Xb-J-Ph1-Z, R-Ph3-G-Xb-J-Ph3-
Z, R-Ph3-J-Xb-Ph-Z, R-Ph3-J-Xb-Ph1-Z, R-Ph3-J-Xb-P
h3-Z, R-Ph3-J-Xb-VO-Ph-Z, R-Ph3-J-Xb-VO-Ph1-Z, RP
h3-J-Xb-VO-Ph3-Z, R-Ph3-J-Xb-T-Ph-Z, R-Ph3-J-Xb-T-
Ph1-Z, R-Ph3-J-Xb-T-Ph3-Z, R-Ph3-J-Xb-G-Ph-Z, R-Ph
3-J-Xb-G-Ph1-Z, R-Ph3-J-Xb-G-Ph3-Z, R-Ph3-J-Xb-JP
hZ, R-Ph3-J-Xb-J-Ph1-Z, R-Ph3-J-Xb-J-Ph3-Z, R-Cy-
Cy-Xa-Z, R-Cy-Cy-2-Xa-Z, R-Cy-Cy-VO-Xa-Z, R-Cy-Cy-
T-Xa-Z, R-Cy-Cy-G-Xa-Z, R-Cy-Cy-J-Xa-Z, R-Cy-Cy-K-
Xa-Z, R-Cy-Ph-Xa-Z, R-Cy-Ph-2-Xa-Z, R-Cy-Ph-VO-Xa-
Z, R-Cy-Ph-T-Xa-Z, R-Cy-Ph-G-Xa-Z, R-Cy-Ph-J-Xa-
Z, R-Cy-Ph-K-Xa-Z, R-Cy-Ph1-Xa-Z, R-Cy-Ph1-2-Xa-
Z, R-Cy-Ph1-VO-Xa-Z, R-Cy-Ph1-T-Xa-Z, R-Cy-Ph1-GX
aZ, R-Cy-Ph1-J-Xa-Z, R-Cy-Ph1-K-Xa-Z, R-Cy-Ph3-Xa
-Z, R-Cy-Ph3-2-Xa-Z, R-Cy-Ph3-VO-Xa-Z, R-Cy-Ph3-T-
Xa-Z, R-Cy-Ph3-G-Xa-Z, R-Cy-Ph3-J-Xa-Z, R-Cy-Ph3-K
-Xa-Z, R-Cy-Ph3-Xa-Z, R-Cy-Ph3-2-Xa-Z, R-Cy-Ph3-VO
-Xa-Z, R-Cy-Ph3-T-Xa-Z, R-Cy-Ph3-G-Xa-Z, R-Cy-Ph3-
J-Xa-Z, R-Cy-Ph3-K-Xa-Z,

【００２４】R-Cy-VO-Cy-Xa-Z、R-Cy-VO-Cy-2-Xa-Z、R-
Cy-VO-Cy-VO-Xa-Z、R-Cy-VO-Cy-T-Xa-Z、R-Cy-VO-Cy-G-
Xa-Z、R-Cy-VO-Cy-J-Xa-Z、R-Cy-VO-Cy-K-Xa-Z、R-Cy-V
O-Ph-Xa-Z、R-Cy-VO-Ph-2-Xa-Z、R-Cy-VO-Ph-VO-Xa-Z、
R-Cy-VO-Ph-T-Xa-Z、R-Cy-VO-Ph-G-Xa-Z、R-Cy-VO-Ph-J
-Xa-Z、R-Cy-VO-Ph-K-Xa-Z、R-Cy-VO-Ph1-Xa-Z、R-Cy-V
O-Ph1-2-Xa-Z、R-Cy-VO-Ph1-VO-Xa-Z、R-Cy-VO-Ph1-T-X
a-Z、R-Cy-VO-Ph1-G-Xa-Z、R-Cy-VO-Ph1-J-Xa-Z、R-Cy-
VO-Ph1-K-Xa-Z、R-Cy-VO-Ph3-Xa-Z、R-Cy-VO-Ph3-2-Xa-
Z、R-Cy-VO-Ph3-VO-Xa-Z、R-Cy-VO-Ph3-T-Xa-Z、R-Cy-V
O-Ph3-G-Xa-Z、R-Cy-VO-Ph3-J-Xa-Z、R-Cy-VO-Ph3-K-Xa
-Z、R-Cy-VO-Ph3-Xa-Z、R-Cy-VO-Ph3-2-Xa-Z、R-Cy-VO-
Ph3-VO-Xa-Z、R-Cy-VO-Ph3-T-Xa-Z、R-Cy-VO-Ph3-G-Xa-
Z、R-Cy-VO-Ph3-J-Xa-Z、R-Cy-VO-Ph3-K-Xa-Z、R-Cy-2-
Cy-Xa-Z、R-Cy-2-Cy-2-Xa-Z、R-Cy-2-Cy-VO-Xa-Z、R-Cy
-2-Cy-T-Xa-Z、R-Cy-2-Cy-G-Xa-Z、R-Cy-2-Cy-J-Xa-Z、
R-Cy-2-Cy-K-Xa-Z、R-Cy-2-Ph-Xa-Z、R-Cy-2-Ph-2-Xa-
Z、R-Cy-2-Ph-VO-Xa-Z、R-Cy-2-Ph-T-Xa-Z、R-Cy-2-Ph-
G-Xa-Z、R-Cy-2-Ph-J-Xa-Z、R-Cy-2-Ph-K-Xa-Z、R-Cy-2
-Ph1-Xa-Z、R-Cy-2-Ph1-2-Xa-Z、R-Cy-2-Ph1-VO-Xa-Z、
R-Cy-2-Ph1-T-Xa-Z、R-Cy-2-Ph1-G-Xa-Z、R-Cy-2-Ph1-J
-Xa-Z、R-Cy-2-Ph1-K-Xa-Z、R-Cy-2-Ph3-Xa-Z、R-Cy-2-
Ph3-2-Xa-Z、R-Cy-2-Ph3-VO-Xa-Z、R-Cy-2-Ph3-T-Xa-
Z、R-Cy-2-Ph3-G-Xa-Z、R-Cy-2-Ph3-J-Xa-Z、R-Cy-2-Ph
3-K-Xa-Z、R-Cy-2-Ph3-Xa-Z、R-Cy-2-Ph3-2-Xa-Z、R-Cy
-2-Ph3-VO-Xa-Z、R-Cy-2-Ph3-T-Xa-Z、R-Cy-2-Ph3-G-Xa
-Z、R-Cy-2-Ph3-J-Xa-Z、R-Cy-2-Ph3-K-Xa-Z、R-Cy-J-C
y-Xa-Z、R-Cy-J-Cy-2-Xa-Z、R-Cy-J-Cy-VO-Xa-Z、R-Cy-
J-Cy-T-Xa-Z、R-Cy-J-Cy-G-Xa-Z、R-Cy-J-Cy-J-Xa-Z、R
-Cy-J-Cy-K-Xa-Z、R-Cy-J-Ph-Xa-Z、R-Cy-J-Ph-2-Xa-
Z、R-Cy-J-Ph-VO-Xa-Z、R-Cy-J-Ph-T-Xa-Z、R-Cy-J-Ph-
G-Xa-Z、R-Cy-J-Ph-J-Xa-Z、R-Cy-J-Ph-K-Xa-Z、R-Cy-J
-Ph1-Xa-Z、R-Cy-J-Ph1-2-Xa-Z、R-Cy-J-Ph1-VO-Xa-Z、
R-Cy-J-Ph1-T-Xa-Z、R-Cy-J-Ph1-G-Xa-Z、R-Cy-J-Ph1-J
-Xa-Z、R-Cy-J-Ph1-K-Xa-Z、R-Cy-J-Ph3-Xa-Z、R-Cy-J-
Ph3-2-Xa-Z、R-Cy-J-Ph3-VO-Xa-Z、R-Cy-J-Ph3-T-Xa-
Z、R-Cy-J-Ph3-G-Xa-Z、R-Cy-J-Ph3-J-Xa-Z、R-Cy-J-Ph
3-K-Xa-Z、R-Cy-J-Ph3-Xa-Z、R-Cy-J-Ph3-2-Xa-Z、R-Cy
-J-Ph3-VO-Xa-Z、R-Cy-J-Ph3-T-Xa-Z、R-Cy-J-Ph3-G-Xa
-Z、R-Cy-J-Ph3-J-Xa-Z、R-Cy-VO-Cy-Xa-Z, R-Cy-VO-Cy-2-Xa-Z, R-
Cy-VO-Cy-VO-Xa-Z, R-Cy-VO-Cy-T-Xa-Z, R-Cy-VO-Cy-G-
Xa-Z, R-Cy-VO-Cy-J-Xa-Z, R-Cy-VO-Cy-K-Xa-Z, R-Cy-V
O-Ph-Xa-Z, R-Cy-VO-Ph-2-Xa-Z, R-Cy-VO-Ph-VO-Xa-Z,
R-Cy-VO-Ph-T-Xa-Z, R-Cy-VO-Ph-G-Xa-Z, R-Cy-VO-Ph-J
-Xa-Z, R-Cy-VO-Ph-K-Xa-Z, R-Cy-VO-Ph1-Xa-Z, R-Cy-V
O-Ph1-2-Xa-Z, R-Cy-VO-Ph1-VO-Xa-Z, R-Cy-VO-Ph1-TX
aZ, R-Cy-VO-Ph1-G-Xa-Z, R-Cy-VO-Ph1-J-Xa-Z, R-Cy-
VO-Ph1-K-Xa-Z, R-Cy-VO-Ph3-Xa-Z, R-Cy-VO-Ph3-2-Xa-
Z, R-Cy-VO-Ph3-VO-Xa-Z, R-Cy-VO-Ph3-T-Xa-Z, R-Cy-V
O-Ph3-G-Xa-Z, R-Cy-VO-Ph3-J-Xa-Z, R-Cy-VO-Ph3-K-Xa
-Z, R-Cy-VO-Ph3-Xa-Z, R-Cy-VO-Ph3-2-Xa-Z, R-Cy-VO-
Ph3-VO-Xa-Z, R-Cy-VO-Ph3-T-Xa-Z, R-Cy-VO-Ph3-G-Xa-
Z, R-Cy-VO-Ph3-J-Xa-Z, R-Cy-VO-Ph3-K-Xa-Z, R-Cy-2-
Cy-Xa-Z, R-Cy-2-Cy-2-Xa-Z, R-Cy-2-Cy-VO-Xa-Z, R-Cy
-2-Cy-T-Xa-Z, R-Cy-2-Cy-G-Xa-Z, R-Cy-2-Cy-J-Xa-Z,
R-Cy-2-Cy-K-Xa-Z, R-Cy-2-Ph-Xa-Z, R-Cy-2-Ph-2-Xa-
Z, R-Cy-2-Ph-VO-Xa-Z, R-Cy-2-Ph-T-Xa-Z, R-Cy-2-Ph-
G-Xa-Z, R-Cy-2-Ph-J-Xa-Z, R-Cy-2-Ph-K-Xa-Z, R-Cy-2
-Ph1-Xa-Z, R-Cy-2-Ph1-2-Xa-Z, R-Cy-2-Ph1-VO-Xa-Z,
R-Cy-2-Ph1-T-Xa-Z, R-Cy-2-Ph1-G-Xa-Z, R-Cy-2-Ph1-J
-Xa-Z, R-Cy-2-Ph1-K-Xa-Z, R-Cy-2-Ph3-Xa-Z, R-Cy-2-
Ph3-2-Xa-Z, R-Cy-2-Ph3-VO-Xa-Z, R-Cy-2-Ph3-T-Xa-
Z, R-Cy-2-Ph3-G-Xa-Z, R-Cy-2-Ph3-J-Xa-Z, R-Cy-2-Ph
3-K-Xa-Z, R-Cy-2-Ph3-Xa-Z, R-Cy-2-Ph3-2-Xa-Z, R-Cy
-2-Ph3-VO-Xa-Z, R-Cy-2-Ph3-T-Xa-Z, R-Cy-2-Ph3-G-Xa
-Z, R-Cy-2-Ph3-J-Xa-Z, R-Cy-2-Ph3-K-Xa-Z, R-Cy-JC
y-Xa-Z, R-Cy-J-Cy-2-Xa-Z, R-Cy-J-Cy-VO-Xa-Z, R-Cy-
J-Cy-T-Xa-Z, R-Cy-J-Cy-G-Xa-Z, R-Cy-J-Cy-J-Xa-Z, R
-Cy-J-Cy-K-Xa-Z, R-Cy-J-Ph-Xa-Z, R-Cy-J-Ph-2-Xa-
Z, R-Cy-J-Ph-VO-Xa-Z, R-Cy-J-Ph-T-Xa-Z, R-Cy-J-Ph-
G-Xa-Z, R-Cy-J-Ph-J-Xa-Z, R-Cy-J-Ph-K-Xa-Z, R-Cy-J
-Ph1-Xa-Z, R-Cy-J-Ph1-2-Xa-Z, R-Cy-J-Ph1-VO-Xa-Z,
R-Cy-J-Ph1-T-Xa-Z, R-Cy-J-Ph1-G-Xa-Z, R-Cy-J-Ph1-J
-Xa-Z, R-Cy-J-Ph1-K-Xa-Z, R-Cy-J-Ph3-Xa-Z, R-Cy-J-
Ph3-2-Xa-Z, R-Cy-J-Ph3-VO-Xa-Z, R-Cy-J-Ph3-T-Xa-
Z, R-Cy-J-Ph3-G-Xa-Z, R-Cy-J-Ph3-J-Xa-Z, R-Cy-J-Ph
3-K-Xa-Z, R-Cy-J-Ph3-Xa-Z, R-Cy-J-Ph3-2-Xa-Z, R-Cy
-J-Ph3-VO-Xa-Z, R-Cy-J-Ph3-T-Xa-Z, R-Cy-J-Ph3-G-Xa
-Z, R-Cy-J-Ph3-J-Xa-Z,

【００２５】R-Cy-J-Ph3-K-Xa-Z、R-Ph-Cy-Xa-Z、R-Ph-
Cy-2-Xa-Z、R-Ph-Cy-VO-Xa-Z、R-Ph-Cy-T-Xa-Z、R-Ph-C
y-G-Xa-Z、R-Ph-Cy-J-Xa-Z、R-Ph-Cy-K-Xa-Z、R-Ph-Ph-
Xa-Z、R-Ph-Ph-2-Xa-Z、R-Ph-Ph-VO-Xa-Z、R-Ph-Ph-T-X
a-Z、R-Ph-Ph-G-Xa-Z、R-Ph-Ph-J-Xa-Z、R-Ph-Ph-K-Xa-
Z、R-Ph-Ph1-Xa-Z、R-Ph-Ph1-2-Xa-Z、R-Ph-Ph1-VO-Xa-
Z、R-Ph-Ph1-T-Xa-Z、R-Ph-Ph1-G-Xa-Z、R-Ph-Ph1-J-Xa
-Z、R-Ph-Ph1-K-Xa-Z、R-Ph-Ph3-Xa-Z、R-Ph-Ph3-2-Xa-
Z、R-Ph-Ph3-VO-Xa-Z、R-Ph-Ph3-T-Xa-Z、R-Ph-Ph3-G-X
a-Z、R-Ph-Ph3-J-Xa-Z、R-Ph-Ph3-K-Xa-Z、R-Ph-Ph3-Xa
-Z、R-Ph-Ph3-2-Xa-Z、R-Ph-Ph3-VO-Xa-Z、R-Ph-Ph3-T-
Xa-Z、R-Ph-Ph3-G-Xa-Z、R-Ph-Ph3-J-Xa-Z、R-Ph-Ph3-K
-Xa-Z、R-Ph-VO-Cy-Xa-Z、R-Ph-VO-Cy-2-Xa-Z、R-Ph-VO
-Cy-VO-Xa-Z、R-Ph-VO-Cy-T-Xa-Z、R-Ph-VO-Cy-G-Xa-
Z、R-Ph-VO-Cy-J-Xa-Z、R-Ph-VO-Cy-K-Xa-Z、R-Ph-VO-P
h-Xa-Z、R-Ph-VO-Ph-2-Xa-Z、R-Ph-VO-Ph-VO-Xa-Z、R-P
h-VO-Ph-T-Xa-Z、R-Ph-VO-Ph-G-Xa-Z、R-Ph-VO-Ph-J-Xa
-Z、R-Ph-VO-Ph-K-Xa-Z、R-Ph-VO-Ph1-Xa-Z、R-Ph-VO-P
h1-2-Xa-Z、R-Ph-VO-Ph1-VO-Xa-Z、R-Ph-VO-Ph1-T-Xa-
Z、R-Ph-VO-Ph1-G-Xa-Z、R-Ph-VO-Ph1-J-Xa-Z、R-Ph-VO
-Ph1-K-Xa-Z、R-Ph-VO-Ph3-Xa-Z、R-Ph-VO-Ph3-2-Xa-
Z、R-Ph-VO-Ph3-VO-Xa-Z、R-Ph-VO-Ph3-T-Xa-Z、R-Ph-V
O-Ph3-G-Xa-Z、R-Ph-VO-Ph3-J-Xa-Z、R-Ph-VO-Ph3-K-Xa
-Z、R-Ph-VO-Ph3-Xa-Z、R-Ph-VO-Ph3-2-Xa-Z、R-Ph-VO-
Ph3-VO-Xa-Z、R-Ph-VO-Ph3-T-Xa-Z、R-Ph-VO-Ph3-G-Xa-
Z、R-Ph-VO-Ph3-J-Xa-Z、R-Ph-VO-Ph3-K-Xa-Z、R-Ph-2-
Cy-Xa-Z、R-Ph-2-Cy-2-Xa-Z、R-Ph-2-Cy-VO-Xa-Z、R-Ph
-2-Cy-T-Xa-Z、R-Ph-2-Cy-G-Xa-Z、R-Ph-2-Cy-J-Xa-Z、
R-Ph-2-Cy-K-Xa-Z、R-Ph-2-Ph-Xa-Z、R-Ph-2-Ph-2-Xa-
Z、R-Ph-2-Ph-VO-Xa-Z、R-Ph-2-Ph-T-Xa-Z、R-Ph-2-Ph-
G-Xa-Z、R-Ph-2-Ph-J-Xa-Z、R-Ph-2-Ph-K-Xa-Z、R-Ph-2
-Ph1-Xa-Z、R-Ph-2-Ph1-2-Xa-Z、R-Ph-2-Ph1-VO-Xa-Z、
R-Ph-2-Ph1-T-Xa-Z、R-Ph-2-Ph1-G-Xa-Z、R-Ph-2-Ph1-J
-Xa-Z、R-Ph-2-Ph1-K-Xa-Z、R-Ph-2-Ph3-Xa-Z、R-Ph-2-
Ph3-2-Xa-Z、R-Ph-2-Ph3-VO-Xa-Z、R-Ph-2-Ph3-T-Xa-
Z、R-Ph-2-Ph3-G-Xa-Z、R-Ph-2-Ph3-J-Xa-Z、R-Ph-2-Ph
3-K-Xa-Z、R-Cy-J-Ph3-K-Xa-Z, R-Ph-Cy-Xa-Z, R-Ph-
Cy-2-Xa-Z, R-Ph-Cy-VO-Xa-Z, R-Ph-Cy-T-Xa-Z, R-Ph-C
yG-Xa-Z, R-Ph-Cy-J-Xa-Z, R-Ph-Cy-K-Xa-Z, R-Ph-Ph-
Xa-Z, R-Ph-Ph-2-Xa-Z, R-Ph-Ph-VO-Xa-Z, R-Ph-Ph-TX
aZ, R-Ph-Ph-G-Xa-Z, R-Ph-Ph-J-Xa-Z, R-Ph-Ph-K-Xa-
Z, R-Ph-Ph1-Xa-Z, R-Ph-Ph1-2-Xa-Z, R-Ph-Ph1-VO-Xa-
Z, R-Ph-Ph1-T-Xa-Z, R-Ph-Ph1-G-Xa-Z, R-Ph-Ph1-J-Xa
-Z, R-Ph-Ph1-K-Xa-Z, R-Ph-Ph3-Xa-Z, R-Ph-Ph3-2-Xa-
Z, R-Ph-Ph3-VO-Xa-Z, R-Ph-Ph3-T-Xa-Z, R-Ph-Ph3-GX
aZ, R-Ph-Ph3-J-Xa-Z, R-Ph-Ph3-K-Xa-Z, R-Ph-Ph3-Xa
-Z, R-Ph-Ph3-2-Xa-Z, R-Ph-Ph3-VO-Xa-Z, R-Ph-Ph3-T-
Xa-Z, R-Ph-Ph3-G-Xa-Z, R-Ph-Ph3-J-Xa-Z, R-Ph-Ph3-K
-Xa-Z, R-Ph-VO-Cy-Xa-Z, R-Ph-VO-Cy-2-Xa-Z, R-Ph-VO
-Cy-VO-Xa-Z, R-Ph-VO-Cy-T-Xa-Z, R-Ph-VO-Cy-G-Xa-
Z, R-Ph-VO-Cy-J-Xa-Z, R-Ph-VO-Cy-K-Xa-Z, R-Ph-VO-P
h-Xa-Z, R-Ph-VO-Ph-2-Xa-Z, R-Ph-VO-Ph-VO-Xa-Z, RP
h-VO-Ph-T-Xa-Z, R-Ph-VO-Ph-G-Xa-Z, R-Ph-VO-Ph-J-Xa
-Z, R-Ph-VO-Ph-K-Xa-Z, R-Ph-VO-Ph1-Xa-Z, R-Ph-VO-P
h1-2-Xa-Z, R-Ph-VO-Ph1-VO-Xa-Z, R-Ph-VO-Ph1-T-Xa-
Z, R-Ph-VO-Ph1-G-Xa-Z, R-Ph-VO-Ph1-J-Xa-Z, R-Ph-VO
-Ph1-K-Xa-Z, R-Ph-VO-Ph3-Xa-Z, R-Ph-VO-Ph3-2-Xa-
Z, R-Ph-VO-Ph3-VO-Xa-Z, R-Ph-VO-Ph3-T-Xa-Z, R-Ph-V
O-Ph3-G-Xa-Z, R-Ph-VO-Ph3-J-Xa-Z, R-Ph-VO-Ph3-K-Xa
-Z, R-Ph-VO-Ph3-Xa-Z, R-Ph-VO-Ph3-2-Xa-Z, R-Ph-VO-
Ph3-VO-Xa-Z, R-Ph-VO-Ph3-T-Xa-Z, R-Ph-VO-Ph3-G-Xa-
Z, R-Ph-VO-Ph3-J-Xa-Z, R-Ph-VO-Ph3-K-Xa-Z, R-Ph-2-
Cy-Xa-Z, R-Ph-2-Cy-2-Xa-Z, R-Ph-2-Cy-VO-Xa-Z, R-Ph
-2-Cy-T-Xa-Z, R-Ph-2-Cy-G-Xa-Z, R-Ph-2-Cy-J-Xa-Z,
R-Ph-2-Cy-K-Xa-Z, R-Ph-2-Ph-Xa-Z, R-Ph-2-Ph-2-Xa-
Z, R-Ph-2-Ph-VO-Xa-Z, R-Ph-2-Ph-T-Xa-Z, R-Ph-2-Ph-
G-Xa-Z, R-Ph-2-Ph-J-Xa-Z, R-Ph-2-Ph-K-Xa-Z, R-Ph-2
-Ph1-Xa-Z, R-Ph-2-Ph1-2-Xa-Z, R-Ph-2-Ph1-VO-Xa-Z,
R-Ph-2-Ph1-T-Xa-Z, R-Ph-2-Ph1-G-Xa-Z, R-Ph-2-Ph1-J
-Xa-Z, R-Ph-2-Ph1-K-Xa-Z, R-Ph-2-Ph3-Xa-Z, R-Ph-2-
Ph3-2-Xa-Z, R-Ph-2-Ph3-VO-Xa-Z, R-Ph-2-Ph3-T-Xa-
Z, R-Ph-2-Ph3-G-Xa-Z, R-Ph-2-Ph3-J-Xa-Z, R-Ph-2-Ph
3-K-Xa-Z,

【００２６】R-Ph-2-Ph3-Xa-Z、R-Ph-2-Ph3-2-Xa-Z、R-
Ph-2-Ph3-VO-Xa-Z、R-Ph-2-Ph3-T-Xa-Z、R-Ph-2-Ph3-G-
Xa-Z、R-Ph-2-Ph3-J-Xa-Z、R-Ph-2-Ph3-K-Xa-Z、R-Ph-J
-Cy-Xa-Z、R-Ph-J-Cy-2-Xa-Z、R-Ph-J-Cy-VO-Xa-Z、R-P
h-J-Cy-T-Xa-Z、R-Ph-J-Cy-G-Xa-Z、R-Ph-J-Cy-J-Xa-
Z、R-Ph-J-Cy-K-Xa-Z、R-Ph-J-Ph-Xa-Z、R-Ph-J-Ph-2-X
a-Z、R-Ph-J-Ph-VO-Xa-Z、R-Ph-J-Ph-T-Xa-Z、R-Ph-J-P
h-G-Xa-Z、R-Ph-J-Ph-J-Xa-Z、R-Ph-J-Ph-K-Xa-Z、R-Ph
-J-Ph1-Xa-Z、R-Ph-J-Ph1-2-Xa-Z、R-Ph-J-Ph1-VO-Xa-
Z、R-Ph-J-Ph1-T-Xa-Z、R-Ph-J-Ph1-G-Xa-Z、R-Ph-J-Ph
1-J-Xa-Z、R-Ph-J-Ph1-K-Xa-Z、R-Ph-J-Ph3-Xa-Z、R-Ph
-J-Ph3-2-Xa-Z、R-Ph-J-Ph3-VO-Xa-Z、R-Ph-J-Ph3-T-Xa
-Z、R-Ph-J-Ph3-G-Xa-Z、R-Ph-J-Ph3-J-Xa-Z、R-Ph-J-P
h3-K-Xa-Z、R-Ph-J-Ph3-Xa-Z、R-Ph-J-Ph3-2-Xa-Z、R-P
h-J-Ph3-VO-Xa-Z、R-Ph-J-Ph3-T-Xa-Z、R-Ph-J-Ph3-G-X
a-Z、R-Ph-J-Ph3-J-Xa-Z、R-Ph-J-Ph3-K-Xa-Z、R-Ph3-C
y-Xa-Z、R-Ph3-Cy-2-Xa-Z、R-Ph3-Cy-VO-Xa-Z、R-Ph3-C
y-T-Xa-Z、R-Ph3-Cy-G-Xa-Z、R-Ph3-Cy-J-Xa-Z、R-Ph3-
Cy-K-Xa-Z、R-Ph3-Ph-Xa-Z、R-Ph3-Ph-2-Xa-Z、R-Ph3-P
h-VO-Xa-Z、R-Ph3-Ph-T-Xa-Z、R-Ph3-Ph-G-Xa-Z、R-Ph3
-Ph-J-Xa-Z、R-Ph3-Ph-K-Xa-Z、R-Ph3-Ph1-Xa-Z、R-Ph3
-Ph1-2-Xa-Z、R-Ph3-Ph1-VO-Xa-Z、R-Ph3-Ph1-T-Xa-Z、
R-Ph3-Ph1-G-Xa-Z、R-Ph3-Ph1-J-Xa-Z、R-Ph3-Ph1-K-Xa
-Z、R-Ph3-Ph3-Xa-Z、R-Ph3-Ph3-2-Xa-Z、R-Ph3-Ph3-VO
-Xa-Z、R-Ph3-Ph3-T-Xa-Z、R-Ph3-Ph3-G-Xa-Z、R-Ph3-P
h3-J-Xa-Z、R-Ph3-Ph3-K-Xa-Z、R-Ph3-Ph3-Xa-Z、R-Ph3
-Ph3-2-Xa-Z、R-Ph3-Ph3-VO-Xa-Z、R-Ph3-Ph3-T-Xa-Z、
R-Ph3-Ph3-G-Xa-Z、R-Ph3-Ph3-J-Xa-Z、R-Ph3-Ph3-K-Xa
-Z、R-Ph-2-Ph3-Xa-Z, R-Ph-2-Ph3-2-Xa-Z, R-
Ph-2-Ph3-VO-Xa-Z, R-Ph-2-Ph3-T-Xa-Z, R-Ph-2-Ph3-G-
Xa-Z, R-Ph-2-Ph3-J-Xa-Z, R-Ph-2-Ph3-K-Xa-Z, R-Ph-J
-Cy-Xa-Z, R-Ph-J-Cy-2-Xa-Z, R-Ph-J-Cy-VO-Xa-Z, RP
hJ-Cy-T-Xa-Z, R-Ph-J-Cy-G-Xa-Z, R-Ph-J-Cy-J-Xa-
Z, R-Ph-J-Cy-K-Xa-Z, R-Ph-J-Ph-Xa-Z, R-Ph-J-Ph-2-X
aZ, R-Ph-J-Ph-VO-Xa-Z, R-Ph-J-Ph-T-Xa-Z, R-Ph-JP
hG-Xa-Z, R-Ph-J-Ph-J-Xa-Z, R-Ph-J-Ph-K-Xa-Z, R-Ph
-J-Ph1-Xa-Z, R-Ph-J-Ph1-2-Xa-Z, R-Ph-J-Ph1-VO-Xa-
Z, R-Ph-J-Ph1-T-Xa-Z, R-Ph-J-Ph1-G-Xa-Z, R-Ph-J-Ph
1-J-Xa-Z, R-Ph-J-Ph1-K-Xa-Z, R-Ph-J-Ph3-Xa-Z, R-Ph
-J-Ph3-2-Xa-Z, R-Ph-J-Ph3-VO-Xa-Z, R-Ph-J-Ph3-T-Xa
-Z, R-Ph-J-Ph3-G-Xa-Z, R-Ph-J-Ph3-J-Xa-Z, R-Ph-JP
h3-K-Xa-Z, R-Ph-J-Ph3-Xa-Z, R-Ph-J-Ph3-2-Xa-Z, RP
hJ-Ph3-VO-Xa-Z, R-Ph-J-Ph3-T-Xa-Z, R-Ph-J-Ph3-GX
aZ, R-Ph-J-Ph3-J-Xa-Z, R-Ph-J-Ph3-K-Xa-Z, R-Ph3-C
y-Xa-Z, R-Ph3-Cy-2-Xa-Z, R-Ph3-Cy-VO-Xa-Z, R-Ph3-C
yT-Xa-Z, R-Ph3-Cy-G-Xa-Z, R-Ph3-Cy-J-Xa-Z, R-Ph3-
Cy-K-Xa-Z, R-Ph3-Ph-Xa-Z, R-Ph3-Ph-2-Xa-Z, R-Ph3-P
h-VO-Xa-Z, R-Ph3-Ph-T-Xa-Z, R-Ph3-Ph-G-Xa-Z, R-Ph3
-Ph-J-Xa-Z, R-Ph3-Ph-K-Xa-Z, R-Ph3-Ph1-Xa-Z, R-Ph3
-Ph1-2-Xa-Z, R-Ph3-Ph1-VO-Xa-Z, R-Ph3-Ph1-T-Xa-Z,
R-Ph3-Ph1-G-Xa-Z, R-Ph3-Ph1-J-Xa-Z, R-Ph3-Ph1-K-Xa
-Z, R-Ph3-Ph3-Xa-Z, R-Ph3-Ph3-2-Xa-Z, R-Ph3-Ph3-VO
-Xa-Z, R-Ph3-Ph3-T-Xa-Z, R-Ph3-Ph3-G-Xa-Z, R-Ph3-P
h3-J-Xa-Z, R-Ph3-Ph3-K-Xa-Z, R-Ph3-Ph3-Xa-Z, R-Ph3
-Ph3-2-Xa-Z, R-Ph3-Ph3-VO-Xa-Z, R-Ph3-Ph3-T-Xa-Z,
R-Ph3-Ph3-G-Xa-Z, R-Ph3-Ph3-J-Xa-Z, R-Ph3-Ph3-K-Xa
-Z,

【００２７】R-Ph3-VO-Cy-Xa-Z、R-Ph3-VO-Cy-2-Xa-Z、
R-Ph3-VO-Cy-VO-Xa-Z、R-Ph3-VO-Cy-T-Xa-Z、R-Ph3-VO-
Cy-G-Xa-Z、R-Ph3-VO-Cy-J-Xa-Z、R-Ph3-VO-Cy-K-Xa-
Z、R-Ph3-VO-Ph-Xa-Z、R-Ph3-VO-Ph-2-Xa-Z、R-Ph3-VO-
Ph-VO-Xa-Z、R-Ph3-VO-Ph-T-Xa-Z、R-Ph3-VO-Ph-G-Xa-
Z、R-Ph3-VO-Ph-J-Xa-Z、R-Ph3-VO-Ph-K-Xa-Z、R-Ph3-V
O-Ph1-Xa-Z、R-Ph3-VO-Ph1-2-Xa-Z、R-Ph3-VO-Ph1-VO-X
a-Z、R-Ph3-VO-Ph1-T-Xa-Z、R-Ph3-VO-Ph1-G-Xa-Z、R-P
h3-VO-Ph1-J-Xa-Z、R-Ph3-VO-Ph1-K-Xa-Z、R-Ph3-VO-Ph
3-Xa-Z、R-Ph3-VO-Ph3-2-Xa-Z、R-Ph3-VO-Ph3-VO-Xa-
Z、R-Ph3-VO-Ph3-T-Xa-Z、R-Ph3-VO-Ph3-G-Xa-Z、R-Ph3
-VO-Ph3-J-Xa-Z、R-Ph3-VO-Ph3-K-Xa-Z、R-Ph3-VO-Ph3-
Xa-Z、R-Ph3-VO-Ph3-2-Xa-Z、R-Ph3-VO-Ph3-VO-Xa-Z、R
-Ph3-VO-Ph3-T-Xa-Z、R-Ph3-VO-Ph3-G-Xa-Z、R-Ph3-VO-
Ph3-J-Xa-Z、R-Ph3-VO-Ph3-K-Xa-Z、R-Ph3-2-Cy-Xa-Z、
R-Ph3-2-Cy-2-Xa-Z、R-Ph3-2-Cy-VO-Xa-Z、R-Ph3-2-Cy-
T-Xa-Z、R-Ph3-2-Cy-G-Xa-Z、R-Ph3-2-Cy-J-Xa-Z、R-Ph
3-2-Cy-K-Xa-Z、R-Ph3-2-Ph-Xa-Z、R-Ph3-2-Ph-2-Xa-
Z、R-Ph3-2-Ph-VO-Xa-Z、R-Ph3-2-Ph-T-Xa-Z、R-Ph3-2-
Ph-G-Xa-Z、R-Ph3-2-Ph-J-Xa-Z、R-Ph3-2-Ph-K-Xa-Z、R
-Ph3-2-Ph1-Xa-Z、R-Ph3-2-Ph1-2-Xa-Z、R-Ph3-2-Ph1-V
O-Xa-Z、R-Ph3-2-Ph1-T-Xa-Z、R-Ph3-2-Ph1-G-Xa-Z、R-
Ph3-2-Ph1-J-Xa-Z、R-Ph3-2-Ph1-K-Xa-Z、R-Ph3-2-Ph3-
Xa-Z、R-Ph3-2-Ph3-2-Xa-Z、R-Ph3-2-Ph3-VO-Xa-Z、R-P
h3-2-Ph3-T-Xa-Z、R-Ph3-2-Ph3-G-Xa-Z、R-Ph3-2-Ph3-J
-Xa-Z、R-Ph3-2-Ph3-K-Xa-Z、R-Ph3-2-Ph3-Xa-Z、R-Ph3
-2-Ph3-2-Xa-Z、R-Ph3-2-Ph3-VO-Xa-Z、R-Ph3-2-Ph3-T-
Xa-Z、R-Ph3-2-Ph3-G-Xa-Z、R-Ph3-2-Ph3-J-Xa-Z、R-Ph
3-2-Ph3-K-Xa-Z、R-Ph3-J-Cy-Xa-Z、R-Ph3-J-Cy-2-Xa-
Z、R-Ph3-J-Cy-VO-Xa-Z、R-Ph3-J-Cy-T-Xa-Z、R-Ph3-J-
Cy-G-Xa-Z、R-Ph3-J-Cy-J-Xa-Z、R-Ph3-J-Cy-K-Xa-Z、R
-Ph3-J-Ph-Xa-Z、R-Ph3-J-Ph-2-Xa-Z、R-Ph3-J-Ph-VO-X
a-Z、R-Ph3-J-Ph-T-Xa-Z、R-Ph3-J-Ph-G-Xa-Z、R-Ph3-J
-Ph-J-Xa-Z、R-Ph3-J-Ph-K-Xa-Z、R-Ph3-J-Ph1-Xa-Z、R
-Ph3-J-Ph1-2-Xa-Z、R-Ph3-J-Ph1-VO-Xa-Z、R-Ph3-J-Ph
1-T-Xa-Z、R-Ph3-J-Ph1-G-Xa-Z、R-Ph3-J-Ph1-J-Xa-Z、
R-Ph3-J-Ph1-K-Xa-Z、R-Ph3-J-Ph3-Xa-Z、R-Ph3-J-Ph3-
2-Xa-Z、R-Ph3-J-Ph3-VO-Xa-Z、R-Ph3-J-Ph3-T-Xa-Z、R
-Ph3-J-Ph3-G-Xa-Z、R-Ph3-J-Ph3-J-Xa-Z、R-Ph3-J-Ph3
-K-Xa-Z、R-Ph3-J-Ph3-Xa-Z、R-Ph3-J-Ph3-2-Xa-Z、R-P
h3-J-Ph3-VO-Xa-Z、R-Ph3-J-Ph3-T-Xa-Z、R-Ph3-J-Ph3-
G-Xa-Z、R-Ph3-J-Ph3-J-Xa-Z、R-Ph3-J-Ph3-K-Xa-Z、R-
By-Cy-Xa-Z、R-By-Cy-2-Xa-Z、R-By-Cy-VO-Xa-Z、R-By-
Cy-T-Xa-Z、R-By-Cy-G-Xa-Z、R-By-Cy-J-Xa-Z、R-By-Cy
-K-Xa-Z、R-By-Ph-Xa-Z、R-By-Ph-2-Xa-Z、R-By-Ph-VO-
Xa-Z、R-By-Ph-T-Xa-Z、R-By-Ph-G-Xa-Z、R-By-Ph-J-Xa
-Z、R-By-Ph-K-Xa-Z、R-By-Ph1-Xa-Z、R-By-Ph1-2-Xa-
Z、R-By-Ph1-VO-Xa-Z、R-By-Ph1-T-Xa-Z、R-By-Ph1-G-X
a-Z、R-By-Ph1-J-Xa-Z、R-By-Ph1-K-Xa-Z、R-By-Ph3-Xa
-Z、R-By-Ph3-2-Xa-Z、R-By-Ph3-VO-Xa-Z、R-By-Ph3-T-
Xa-Z、R-By-Ph3-G-Xa-Z、R-By-Ph3-J-Xa-Z、R-By-Ph3-K
-Xa-Z、R-By-Ph3-Xa-Z、R-By-Ph3-2-Xa-Z、R-By-Ph3-VO
-Xa-Z、R-By-Ph3-T-Xa-Z、R-By-Ph3-G-Xa-Z、R-By-Ph3-
J-Xa-Z、R-Ph3-VO-Cy-Xa-Z, R-Ph3-VO-Cy-2-Xa-Z,
R-Ph3-VO-Cy-VO-Xa-Z, R-Ph3-VO-Cy-T-Xa-Z, R-Ph3-VO-
Cy-G-Xa-Z, R-Ph3-VO-Cy-J-Xa-Z, R-Ph3-VO-Cy-K-Xa-
Z, R-Ph3-VO-Ph-Xa-Z, R-Ph3-VO-Ph-2-Xa-Z, R-Ph3-VO-
Ph-VO-Xa-Z, R-Ph3-VO-Ph-T-Xa-Z, R-Ph3-VO-Ph-G-Xa-
Z, R-Ph3-VO-Ph-J-Xa-Z, R-Ph3-VO-Ph-K-Xa-Z, R-Ph3-V
O-Ph1-Xa-Z, R-Ph3-VO-Ph1-2-Xa-Z, R-Ph3-VO-Ph1-VO-X
aZ, R-Ph3-VO-Ph1-T-Xa-Z, R-Ph3-VO-Ph1-G-Xa-Z, RP
h3-VO-Ph1-J-Xa-Z, R-Ph3-VO-Ph1-K-Xa-Z, R-Ph3-VO-Ph
3-Xa-Z, R-Ph3-VO-Ph3-2-Xa-Z, R-Ph3-VO-Ph3-VO-Xa-
Z, R-Ph3-VO-Ph3-T-Xa-Z, R-Ph3-VO-Ph3-G-Xa-Z, R-Ph3
-VO-Ph3-J-Xa-Z, R-Ph3-VO-Ph3-K-Xa-Z, R-Ph3-VO-Ph3-
Xa-Z, R-Ph3-VO-Ph3-2-Xa-Z, R-Ph3-VO-Ph3-VO-Xa-Z, R
-Ph3-VO-Ph3-T-Xa-Z, R-Ph3-VO-Ph3-G-Xa-Z, R-Ph3-VO-
Ph3-J-Xa-Z, R-Ph3-VO-Ph3-K-Xa-Z, R-Ph3-2-Cy-Xa-Z,
R-Ph3-2-Cy-2-Xa-Z, R-Ph3-2-Cy-VO-Xa-Z, R-Ph3-2-Cy-
T-Xa-Z, R-Ph3-2-Cy-G-Xa-Z, R-Ph3-2-Cy-J-Xa-Z, R-Ph
3-2-Cy-K-Xa-Z, R-Ph3-2-Ph-Xa-Z, R-Ph3-2-Ph-2-Xa-
Z, R-Ph3-2-Ph-VO-Xa-Z, R-Ph3-2-Ph-T-Xa-Z, R-Ph3-2-
Ph-G-Xa-Z, R-Ph3-2-Ph-J-Xa-Z, R-Ph3-2-Ph-K-Xa-Z, R
-Ph3-2-Ph1-Xa-Z, R-Ph3-2-Ph1-2-Xa-Z, R-Ph3-2-Ph1-V
O-Xa-Z, R-Ph3-2-Ph1-T-Xa-Z, R-Ph3-2-Ph1-G-Xa-Z, R-
Ph3-2-Ph1-J-Xa-Z, R-Ph3-2-Ph1-K-Xa-Z, R-Ph3-2-Ph3-
Xa-Z, R-Ph3-2-Ph3-2-Xa-Z, R-Ph3-2-Ph3-VO-Xa-Z, RP
h3-2-Ph3-T-Xa-Z, R-Ph3-2-Ph3-G-Xa-Z, R-Ph3-2-Ph3-J
-Xa-Z, R-Ph3-2-Ph3-K-Xa-Z, R-Ph3-2-Ph3-Xa-Z, R-Ph3
-2-Ph3-2-Xa-Z, R-Ph3-2-Ph3-VO-Xa-Z, R-Ph3-2-Ph3-T-
Xa-Z, R-Ph3-2-Ph3-G-Xa-Z, R-Ph3-2-Ph3-J-Xa-Z, R-Ph
3-2-Ph3-K-Xa-Z, R-Ph3-J-Cy-Xa-Z, R-Ph3-J-Cy-2-Xa-
Z, R-Ph3-J-Cy-VO-Xa-Z, R-Ph3-J-Cy-T-Xa-Z, R-Ph3-J-
Cy-G-Xa-Z, R-Ph3-J-Cy-J-Xa-Z, R-Ph3-J-Cy-K-Xa-Z, R
-Ph3-J-Ph-Xa-Z, R-Ph3-J-Ph-2-Xa-Z, R-Ph3-J-Ph-VO-X
aZ, R-Ph3-J-Ph-T-Xa-Z, R-Ph3-J-Ph-G-Xa-Z, R-Ph3-J
-Ph-J-Xa-Z, R-Ph3-J-Ph-K-Xa-Z, R-Ph3-J-Ph1-Xa-Z, R
-Ph3-J-Ph1-2-Xa-Z, R-Ph3-J-Ph1-VO-Xa-Z, R-Ph3-J-Ph
1-T-Xa-Z, R-Ph3-J-Ph1-G-Xa-Z, R-Ph3-J-Ph1-J-Xa-Z,
R-Ph3-J-Ph1-K-Xa-Z, R-Ph3-J-Ph3-Xa-Z, R-Ph3-J-Ph3-
2-Xa-Z, R-Ph3-J-Ph3-VO-Xa-Z, R-Ph3-J-Ph3-T-Xa-Z, R
-Ph3-J-Ph3-G-Xa-Z, R-Ph3-J-Ph3-J-Xa-Z, R-Ph3-J-Ph3
-K-Xa-Z, R-Ph3-J-Ph3-Xa-Z, R-Ph3-J-Ph3-2-Xa-Z, RP
h3-J-Ph3-VO-Xa-Z, R-Ph3-J-Ph3-T-Xa-Z, R-Ph3-J-Ph3-
G-Xa-Z, R-Ph3-J-Ph3-J-Xa-Z, R-Ph3-J-Ph3-K-Xa-Z, R-
By-Cy-Xa-Z, R-By-Cy-2-Xa-Z, R-By-Cy-VO-Xa-Z, R-By-
Cy-T-Xa-Z, R-By-Cy-G-Xa-Z, R-By-Cy-J-Xa-Z, R-By-Cy
-K-Xa-Z, R-By-Ph-Xa-Z, R-By-Ph-2-Xa-Z, R-By-Ph-VO-
Xa-Z, R-By-Ph-T-Xa-Z, R-By-Ph-G-Xa-Z, R-By-Ph-J-Xa
-Z, R-By-Ph-K-Xa-Z, R-By-Ph1-Xa-Z, R-By-Ph1-2-Xa-
Z, R-By-Ph1-VO-Xa-Z, R-By-Ph1-T-Xa-Z, R-By-Ph1-GX
aZ, R-By-Ph1-J-Xa-Z, R-By-Ph1-K-Xa-Z, R-By-Ph3-Xa
-Z, R-By-Ph3-2-Xa-Z, R-By-Ph3-VO-Xa-Z, R-By-Ph3-T-
Xa-Z, R-By-Ph3-G-Xa-Z, R-By-Ph3-J-Xa-Z, R-By-Ph3-K
-Xa-Z, R-By-Ph3-Xa-Z, R-By-Ph3-2-Xa-Z, R-By-Ph3-VO
-Xa-Z, R-By-Ph3-T-Xa-Z, R-By-Ph3-G-Xa-Z, R-By-Ph3-
J-Xa-Z,

【００２８】R-By-Ph3-K-Xa-Z、R-By-VO-Cy-Xa-Z、R-By
-VO-Cy-2-Xa-Z、R-By-VO-Cy-VO-Xa-Z、R-By-VO-Cy-T-Xa
-Z、R-By-VO-Cy-G-Xa-Z、R-By-VO-Cy-J-Xa-Z、R-By-VO-
Cy-K-Xa-Z、R-By-VO-Ph-Xa-Z、R-By-VO-Ph-2-Xa-Z、R-B
y-VO-Ph-VO-Xa-Z、R-By-VO-Ph-T-Xa-Z、R-By-VO-Ph-G-X
a-Z、R-By-VO-Ph-J-Xa-Z、R-By-VO-Ph-K-Xa-Z、R-By-VO
-Ph1-Xa-Z、R-By-VO-Ph1-2-Xa-Z、R-By-VO-Ph1-VO-Xa-
Z、R-By-VO-Ph1-T-Xa-Z、R-By-VO-Ph1-G-Xa-Z、R-By-VO
-Ph1-J-Xa-Z、R-By-VO-Ph1-K-Xa-Z、R-By-VO-Ph3-Xa-
Z、R-By-VO-Ph3-2-Xa-Z、R-By-VO-Ph3-VO-Xa-Z、R-By-V
O-Ph3-T-Xa-Z、R-By-VO-Ph3-G-Xa-Z、R-By-VO-Ph3-J-Xa
-Z、R-By-VO-Ph3-K-Xa-Z、R-By-VO-Ph3-Xa-Z、R-By-VO-
Ph3-2-Xa-Z、R-By-VO-Ph3-VO-Xa-Z、R-By-VO-Ph3-T-Xa-
Z、R-By-VO-Ph3-G-Xa-Z、R-By-VO-Ph3-J-Xa-Z、R-By-VO
-Ph3-K-Xa-Z、R-By-2-Cy-Xa-Z、R-By-2-Cy-2-Xa-Z、R-B
y-2-Cy-VO-Xa-Z、R-By-2-Cy-T-Xa-Z、R-By-2-Cy-G-Xa-
Z、R-By-2-Cy-J-Xa-Z、R-By-2-Cy-K-Xa-Z、R-By-2-Ph-X
a-Z、R-By-2-Ph-2-Xa-Z、R-By-2-Ph-VO-Xa-Z、R-By-2-P
h-T-Xa-Z、R-By-2-Ph-G-Xa-Z、R-By-2-Ph-J-Xa-Z、R-By
-2-Ph-K-Xa-Z、R-By-2-Ph1-Xa-Z、R-By-2-Ph1-2-Xa-Z、
R-By-2-Ph1-VO-Xa-Z、R-By-2-Ph1-T-Xa-Z、R-By-2-Ph1-
G-Xa-Z、R-By-2-Ph1-J-Xa-Z、R-By-2-Ph1-K-Xa-Z、R-By
-2-Ph3-Xa-Z、R-By-2-Ph3-2-Xa-Z、R-By-2-Ph3-VO-Xa-
Z、R-By-2-Ph3-T-Xa-Z、R-By-2-Ph3-G-Xa-Z、R-By-2-Ph
3-J-Xa-Z、R-By-2-Ph3-K-Xa-Z、R-By-2-Ph3-Xa-Z、R-By
-2-Ph3-2-Xa-Z、R-By-2-Ph3-VO-Xa-Z、R-By-2-Ph3-T-Xa
-Z、R-By-2-Ph3-G-Xa-Z、R-By-2-Ph3-J-Xa-Z、R-By-2-P
h3-K-Xa-Z、R-By-J-Cy-Xa-Z、R-By-J-Cy-2-Xa-Z、R-By-
J-Cy-VO-Xa-Z、R-By-J-Cy-T-Xa-Z、R-By-J-Cy-G-Xa-Z、
R-By-J-Cy-J-Xa-Z、R-By-J-Cy-K-Xa-Z、R-By-J-Ph-Xa-
Z、R-By-J-Ph-2-Xa-Z、R-By-J-Ph-VO-Xa-Z、R-By-J-Ph-
T-Xa-Z、R-By-J-Ph-G-Xa-Z、R-By-J-Ph-J-Xa-Z、R-By-J
-Ph-K-Xa-Z、R-By-J-Ph1-Xa-Z、R-By-J-Ph1-2-Xa-Z、R-
By-J-Ph1-VO-Xa-Z、R-By-J-Ph1-T-Xa-Z、R-By-J-Ph1-G-
Xa-Z、R-By-J-Ph1-J-Xa-Z、R-By-J-Ph1-K-Xa-Z、R-By-J
-Ph3-Xa-Z、R-By-J-Ph3-2-Xa-Z、R-By-J-Ph3-VO-Xa-Z、
R-By-J-Ph3-T-Xa-Z、R-By-J-Ph3-G-Xa-Z、R-By-J-Ph3-J
-Xa-Z、R-By-J-Ph3-K-Xa-Z、R-By-J-Ph3-Xa-Z、R-By-J-
Ph3-2-Xa-Z、R-By-J-Ph3-VO-Xa-Z、R-By-Ph3-K-Xa-Z, R-By-VO-Cy-Xa-Z, R-By
-VO-Cy-2-Xa-Z, R-By-VO-Cy-VO-Xa-Z, R-By-VO-Cy-T-Xa
-Z, R-By-VO-Cy-G-Xa-Z, R-By-VO-Cy-J-Xa-Z, R-By-VO-
Cy-K-Xa-Z, R-By-VO-Ph-Xa-Z, R-By-VO-Ph-2-Xa-Z, RB
y-VO-Ph-VO-Xa-Z, R-By-VO-Ph-T-Xa-Z, R-By-VO-Ph-GX
aZ, R-By-VO-Ph-J-Xa-Z, R-By-VO-Ph-K-Xa-Z, R-By-VO
-Ph1-Xa-Z, R-By-VO-Ph1-2-Xa-Z, R-By-VO-Ph1-VO-Xa-
Z, R-By-VO-Ph1-T-Xa-Z, R-By-VO-Ph1-G-Xa-Z, R-By-VO
-Ph1-J-Xa-Z, R-By-VO-Ph1-K-Xa-Z, R-By-VO-Ph3-Xa-
Z, R-By-VO-Ph3-2-Xa-Z, R-By-VO-Ph3-VO-Xa-Z, R-By-V
O-Ph3-T-Xa-Z, R-By-VO-Ph3-G-Xa-Z, R-By-VO-Ph3-J-Xa
-Z, R-By-VO-Ph3-K-Xa-Z, R-By-VO-Ph3-Xa-Z, R-By-VO-
Ph3-2-Xa-Z, R-By-VO-Ph3-VO-Xa-Z, R-By-VO-Ph3-T-Xa-
Z, R-By-VO-Ph3-G-Xa-Z, R-By-VO-Ph3-J-Xa-Z, R-By-VO
-Ph3-K-Xa-Z, R-By-2-Cy-Xa-Z, R-By-2-Cy-2-Xa-Z, RB
y-2-Cy-VO-Xa-Z, R-By-2-Cy-T-Xa-Z, R-By-2-Cy-G-Xa-
Z, R-By-2-Cy-J-Xa-Z, R-By-2-Cy-K-Xa-Z, R-By-2-Ph-X
aZ, R-By-2-Ph-2-Xa-Z, R-By-2-Ph-VO-Xa-Z, R-By-2-P
hT-Xa-Z, R-By-2-Ph-G-Xa-Z, R-By-2-Ph-J-Xa-Z, R-By
-2-Ph-K-Xa-Z, R-By-2-Ph1-Xa-Z, R-By-2-Ph1-2-Xa-Z,
R-By-2-Ph1-VO-Xa-Z, R-By-2-Ph1-T-Xa-Z, R-By-2-Ph1-
G-Xa-Z, R-By-2-Ph1-J-Xa-Z, R-By-2-Ph1-K-Xa-Z, R-By
-2-Ph3-Xa-Z, R-By-2-Ph3-2-Xa-Z, R-By-2-Ph3-VO-Xa-
Z, R-By-2-Ph3-T-Xa-Z, R-By-2-Ph3-G-Xa-Z, R-By-2-Ph
3-J-Xa-Z, R-By-2-Ph3-K-Xa-Z, R-By-2-Ph3-Xa-Z, R-By
-2-Ph3-2-Xa-Z, R-By-2-Ph3-VO-Xa-Z, R-By-2-Ph3-T-Xa
-Z, R-By-2-Ph3-G-Xa-Z, R-By-2-Ph3-J-Xa-Z, R-By-2-P
h3-K-Xa-Z, R-By-J-Cy-Xa-Z, R-By-J-Cy-2-Xa-Z, R-By-
J-Cy-VO-Xa-Z, R-By-J-Cy-T-Xa-Z, R-By-J-Cy-G-Xa-Z,
R-By-J-Cy-J-Xa-Z, R-By-J-Cy-K-Xa-Z, R-By-J-Ph-Xa-
Z, R-By-J-Ph-2-Xa-Z, R-By-J-Ph-VO-Xa-Z, R-By-J-Ph-
T-Xa-Z, R-By-J-Ph-G-Xa-Z, R-By-J-Ph-J-Xa-Z, R-By-J
-Ph-K-Xa-Z, R-By-J-Ph1-Xa-Z, R-By-J-Ph1-2-Xa-Z, R-
By-J-Ph1-VO-Xa-Z, R-By-J-Ph1-T-Xa-Z, R-By-J-Ph1-G-
Xa-Z, R-By-J-Ph1-J-Xa-Z, R-By-J-Ph1-K-Xa-Z, R-By-J
-Ph3-Xa-Z, R-By-J-Ph3-2-Xa-Z, R-By-J-Ph3-VO-Xa-Z,
R-By-J-Ph3-T-Xa-Z, R-By-J-Ph3-G-Xa-Z, R-By-J-Ph3-J
-Xa-Z, R-By-J-Ph3-K-Xa-Z, R-By-J-Ph3-Xa-Z, R-By-J-
Ph3-2-Xa-Z, R-By-J-Ph3-VO-Xa-Z,

【００２９】R-By-J-Ph3-T-Xa-Z、R-By-J-Ph3-G-Xa-Z、
R-By-J-Ph3-J-Xa-Z、R-By-J-Ph3-K-Xa-Z、R-Cy-2-Cy-2-
Xa-T-Ph-Z、R-Cy-2-Cy-2-Xa-T-Ph1-Z、R-Cy-2-Cy-2-Xa-
T-Ph3-Z、R-Cy-2-Cy-J-Xa-T-Ph-Z、R-Cy-2-Cy-J-Xa-T-P
h1-Z、R-Cy-2-Cy-J-Xa-T-Ph3-Z、R-Cy-2-Cy-Xa-T-Ph-
Z、R-Cy-2-Cy-Xa-T-Ph1-Z、R-Cy-2-Cy-Xa-T-Ph3-Z、R-C
y-Cy-2-Xa-T-Ph-Z、R-Cy-Cy-2-Xa-T-Ph1-Z、R-Cy-Cy-2-
Xa-T-Ph3-Z、R-Cy-Cy-J-Xa-T-Ph-Z、R-Cy-Cy-J-Xa-T-Ph
1-Z、R-Cy-Cy-J-Xa-T-Ph3-Z、R-Cy-Cy-Xa-T-Ph-Z、R-Cy
-Cy-Xa-T-Ph1-Z、R-Cy-Cy-Xa-T-Ph3-Z、R-Cy-2-Cy-2-Xa
-VO-Ph-Z、R-Cy-2-Cy-2-Xa-VO-Ph1-Z、R-Cy-2-Cy-2-Xa-
VO-Ph3-Z、R-Cy-2-Cy-J-Xa-VO-Ph-Z、R-Cy-2-Cy-J-Xa-V
O-Ph1-Z、R-Cy-2-Cy-J-Xa-VO-Ph3-Z、R-Cy-2-Cy-Xa-VO-
Ph-Z、R-Cy-2-Cy-Xa-VO-Ph1-Z、R-Cy-2-Cy-Xa-VO-Ph3-
Z、R-Cy-Cy-2-Xa-VO-Ph-Z、R-Cy-Cy-2-Xa-VO-Ph1-Z、R-
Cy-Cy-2-Xa-VO-Ph3-Z、R-Cy-Cy-J-Xa-VO-Ph-Z、R-Cy-Cy
-J-Xa-VO-Ph1-Z、R-Cy-Cy-J-Xa-VO-Ph3-Z、R-Cy-Cy-Xa-
VO-Ph-Z、R-Cy-Cy-Xa-VO-Ph1-Z、R-Cy-Cy-Xa-VO-Ph3-
Z、R-Cy-2-Cy-2-Xa-Cy-Z、R-Cy-2-Cy-2-Xa-Ph-Z、R-Cy-
2-Cy-2-Xa-Ph1-Z、R-Cy-2-Cy-2-Xa-Ph3-Z、R-Cy-2-Cy-J
-Xa-Cy-Z、R-Cy-2-Cy-J-Xa-Ph-Z、R-Cy-2-Cy-J-Xa-Ph1-
Z、R-Cy-2-Cy-J-Xa-Ph3-Z、R-Cy-2-Cy-Xa-Cy-Z、R-Cy-2
-Cy-Xa-Ph-Z、R-Cy-2-Cy-Xa-Ph1-Z、R-Cy-2-Cy-Xa-Ph3-
Z、R-Cy-Cy-2-Xa-Cy-Z、R-Cy-Cy-2-Xa-Ph-Z、R-Cy-Cy-2
-Xa-Ph1-Z、R-Cy-Cy-2-Xa-Ph3-Z、R-Cy-Cy-J-Xa-Cy-Z、
R-Cy-Cy-J-Xa-Ph-Z、R-Cy-Cy-J-Xa-Ph1-Z、R-Cy-Cy-J-X
a-Ph3-Z、R-Cy-Cy-Xa-Cy-Z、R-Cy-Cy-Xa-Ph-Z、R-Cy-Cy
-Xa-Ph1-Z、R-Cy-Cy-Xa-Ph3-Z、R-Cy-2-Ph-2-Xa-T-Ph-
Z、R-Cy-2-Ph-2-Xa-T-Ph1-Z、R-Cy-2-Ph-2-Xa-T-Ph3-
Z、R-Cy-2-Ph-T-Xa-T-Ph-Z、R-Cy-2-Ph-T-Xa-T-Ph1-Z、
R-Cy-2-Ph-T-Xa-T-Ph3-Z、R-Cy-2-Ph-Xa-T-Ph-Z、R-Cy-
2-Ph-Xa-T-Ph1-Z、R-Cy-2-Ph-Xa-T-Ph3-Z、R-Cy-T-Ph-2
-Xa-T-Ph-Z、R-Cy-T-Ph-2-Xa-T-Ph1-Z、R-Cy-T-Ph-2-Xa
-T-Ph3-Z、R-Cy-T-Ph-T-Xa-T-Ph-Z、R-Cy-T-Ph-T-Xa-T-
Ph1-Z、R-Cy-T-Ph-T-Xa-T-Ph3-Z、R-Cy-T-Ph-Xa-T-Ph-
Z、R-Cy-T-Ph-Xa-T-Ph1-Z、R-Cy-T-Ph-Xa-T-Ph3-Z、R-C
y-Ph-2-Xa-T-Ph-Z、R-Cy-Ph-2-Xa-T-Ph1-Z、R-Cy-Ph-2-
Xa-T-Ph3-Z、R-Cy-Ph-T-Xa-T-Ph-Z、R-Cy-Ph-T-Xa-T-Ph
1-Z、R-Cy-Ph-T-Xa-T-Ph3-Z、R-Cy-Ph-Xa-T-Ph-Z、R-Cy
-Ph-Xa-T-Ph1-Z、R-Cy-Ph-Xa-T-Ph3-Z、R-Cy-2-Ph-2-Xa
-VO-Ph-Z、R-Cy-2-Ph-2-Xa-VO-Ph1-Z、R-Cy-2-Ph-2-Xa-
VO-Ph3-Z、R-Cy-2-Ph-T-Xa-VO-Ph-Z、R-Cy-2-Ph-T-Xa-V
O-Ph1-Z、R-Cy-2-Ph-T-Xa-VO-Ph3-Z、R-Cy-2-Ph-Xa-VO-
Ph-Z、R-Cy-2-Ph-Xa-VO-Ph1-Z、R-Cy-2-Ph-Xa-VO-Ph3-
Z、R-Cy-T-Ph-2-Xa-VO-Ph-Z、R-Cy-T-Ph-2-Xa-VO-Ph1-
Z、R-Cy-T-Ph-2-Xa-VO-Ph3-Z、R-Cy-T-Ph-T-Xa-VO-Ph-
Z、R-Cy-T-Ph-T-Xa-VO-Ph1-Z、R-Cy-T-Ph-T-Xa-VO-Ph3-
Z、R-Cy-T-Ph-Xa-VO-Ph-Z、R-Cy-T-Ph-Xa-VO-Ph1-Z、R-
Cy-T-Ph-Xa-VO-Ph3-Z、R-Cy-Ph-2-Xa-VO-Ph-Z、R-Cy-Ph
-2-Xa-VO-Ph1-Z、R-Cy-Ph-2-Xa-VO-Ph3-Z、R-Cy-Ph-T-X
a-VO-Ph-Z、R-Cy-Ph-T-Xa-VO-Ph1-Z、R-Cy-Ph-T-Xa-VO-
Ph3-Z、R-Cy-Ph-Xa-VO-Ph-Z、R-Cy-Ph-Xa-VO-Ph1-Z、R-
Cy-Ph-Xa-VO-Ph3-Z、R-Cy-2-Ph-2-Xa-Cy-Z、R-Cy-2-Ph-
2-Xa-Ph-Z、R-Cy-2-Ph-2-Xa-Ph1-Z、R-Cy-2-Ph-2-Xa-Ph
3-Z、R-Cy-2-Ph-T-Xa-Cy-Z、R-Cy-2-Ph-T-Xa-Ph-Z、R-C
y-2-Ph-T-Xa-Ph1-Z、R-Cy-2-Ph-T-Xa-Ph3-Z、R-Cy-2-Ph
-Xa-Cy-Z、R-Cy-2-Ph-Xa-Ph-Z、R-Cy-2-Ph-Xa-Ph1-Z、R
-Cy-2-Ph-Xa-Ph3-Z、R-Cy-T-Ph-2-Xa-Cy-Z、R-Cy-T-Ph-
2-Xa-Ph-Z、R-Cy-T-Ph-2-Xa-Ph1-Z、R-Cy-T-Ph-2-Xa-Ph
3-Z、R-Cy-T-Ph-T-Xa-Cy-Z、R-Cy-T-Ph-T-Xa-Ph-Z、R-C
y-T-Ph-T-Xa-Ph1-Z、R-Cy-T-Ph-T-Xa-Ph3-Z、R-Cy-T-Ph
-Xa-Cy-Z、R-Cy-T-Ph-Xa-Ph-Z、R-Cy-T-Ph-Xa-Ph1-Z、R
-Cy-T-Ph-Xa-Ph3-Z、R-Cy-Ph-2-Xa-Cy-Z、R-Cy-Ph-2-Xa
-Ph-Z、R-Cy-Ph-2-Xa-Ph1-Z、R-Cy-Ph-2-Xa-Ph3-Z、R-By-J-Ph3-T-Xa-Z, R-By-J-Ph3-G-Xa-Z,
R-By-J-Ph3-J-Xa-Z, R-By-J-Ph3-K-Xa-Z, R-Cy-2-Cy-2-
Xa-T-Ph-Z, R-Cy-2-Cy-2-Xa-T-Ph1-Z, R-Cy-2-Cy-2-Xa-
T-Ph3-Z, R-Cy-2-Cy-J-Xa-T-Ph-Z, R-Cy-2-Cy-J-Xa-TP
h1-Z, R-Cy-2-Cy-J-Xa-T-Ph3-Z, R-Cy-2-Cy-Xa-T-Ph-
Z, R-Cy-2-Cy-Xa-T-Ph1-Z, R-Cy-2-Cy-Xa-T-Ph3-Z, RC
y-Cy-2-Xa-T-Ph-Z, R-Cy-Cy-2-Xa-T-Ph1-Z, R-Cy-Cy-2-
Xa-T-Ph3-Z, R-Cy-Cy-J-Xa-T-Ph-Z, R-Cy-Cy-J-Xa-T-Ph
1-Z, R-Cy-Cy-J-Xa-T-Ph3-Z, R-Cy-Cy-Xa-T-Ph-Z, R-Cy
-Cy-Xa-T-Ph1-Z, R-Cy-Cy-Xa-T-Ph3-Z, R-Cy-2-Cy-2-Xa
-VO-Ph-Z, R-Cy-2-Cy-2-Xa-VO-Ph1-Z, R-Cy-2-Cy-2-Xa-
VO-Ph3-Z, R-Cy-2-Cy-J-Xa-VO-Ph-Z, R-Cy-2-Cy-J-Xa-V
O-Ph1-Z, R-Cy-2-Cy-J-Xa-VO-Ph3-Z, R-Cy-2-Cy-Xa-VO-
Ph-Z, R-Cy-2-Cy-Xa-VO-Ph1-Z, R-Cy-2-Cy-Xa-VO-Ph3-
Z, R-Cy-Cy-2-Xa-VO-Ph-Z, R-Cy-Cy-2-Xa-VO-Ph1-Z, R-
Cy-Cy-2-Xa-VO-Ph3-Z, R-Cy-Cy-J-Xa-VO-Ph-Z, R-Cy-Cy
-J-Xa-VO-Ph1-Z, R-Cy-Cy-J-Xa-VO-Ph3-Z, R-Cy-Cy-Xa-
VO-Ph-Z, R-Cy-Cy-Xa-VO-Ph1-Z, R-Cy-Cy-Xa-VO-Ph3-
Z, R-Cy-2-Cy-2-Xa-Cy-Z, R-Cy-2-Cy-2-Xa-Ph-Z, R-Cy-
2-Cy-2-Xa-Ph1-Z, R-Cy-2-Cy-2-Xa-Ph3-Z, R-Cy-2-Cy-J
-Xa-Cy-Z, R-Cy-2-Cy-J-Xa-Ph-Z, R-Cy-2-Cy-J-Xa-Ph1-
Z, R-Cy-2-Cy-J-Xa-Ph3-Z, R-Cy-2-Cy-Xa-Cy-Z, R-Cy-2
-Cy-Xa-Ph-Z, R-Cy-2-Cy-Xa-Ph1-Z, R-Cy-2-Cy-Xa-Ph3-
Z, R-Cy-Cy-2-Xa-Cy-Z, R-Cy-Cy-2-Xa-Ph-Z, R-Cy-Cy-2
-Xa-Ph1-Z, R-Cy-Cy-2-Xa-Ph3-Z, R-Cy-Cy-J-Xa-Cy-Z,
R-Cy-Cy-J-Xa-Ph-Z, R-Cy-Cy-J-Xa-Ph1-Z, R-Cy-Cy-JX
a-Ph3-Z, R-Cy-Cy-Xa-Cy-Z, R-Cy-Cy-Xa-Ph-Z, R-Cy-Cy
-Xa-Ph1-Z, R-Cy-Cy-Xa-Ph3-Z, R-Cy-2-Ph-2-Xa-T-Ph-
Z, R-Cy-2-Ph-2-Xa-T-Ph1-Z, R-Cy-2-Ph-2-Xa-T-Ph3-
Z, R-Cy-2-Ph-T-Xa-T-Ph-Z, R-Cy-2-Ph-T-Xa-T-Ph1-Z,
R-Cy-2-Ph-T-Xa-T-Ph3-Z, R-Cy-2-Ph-Xa-T-Ph-Z, R-Cy-
2-Ph-Xa-T-Ph1-Z, R-Cy-2-Ph-Xa-T-Ph3-Z, R-Cy-T-Ph-2
-Xa-T-Ph-Z, R-Cy-T-Ph-2-Xa-T-Ph1-Z, R-Cy-T-Ph-2-Xa
-T-Ph3-Z, R-Cy-T-Ph-T-Xa-T-Ph-Z, R-Cy-T-Ph-T-Xa-T-
Ph1-Z, R-Cy-T-Ph-T-Xa-T-Ph3-Z, R-Cy-T-Ph-Xa-T-Ph-
Z, R-Cy-T-Ph-Xa-T-Ph1-Z, R-Cy-T-Ph-Xa-T-Ph3-Z, RC
y-Ph-2-Xa-T-Ph-Z, R-Cy-Ph-2-Xa-T-Ph1-Z, R-Cy-Ph-2-
Xa-T-Ph3-Z, R-Cy-Ph-T-Xa-T-Ph-Z, R-Cy-Ph-T-Xa-T-Ph
1-Z, R-Cy-Ph-T-Xa-T-Ph3-Z, R-Cy-Ph-Xa-T-Ph-Z, R-Cy
-Ph-Xa-T-Ph1-Z, R-Cy-Ph-Xa-T-Ph3-Z, R-Cy-2-Ph-2-Xa
-VO-Ph-Z, R-Cy-2-Ph-2-Xa-VO-Ph1-Z, R-Cy-2-Ph-2-Xa-
VO-Ph3-Z, R-Cy-2-Ph-T-Xa-VO-Ph-Z, R-Cy-2-Ph-T-Xa-V
O-Ph1-Z, R-Cy-2-Ph-T-Xa-VO-Ph3-Z, R-Cy-2-Ph-Xa-VO-
Ph-Z, R-Cy-2-Ph-Xa-VO-Ph1-Z, R-Cy-2-Ph-Xa-VO-Ph3-
Z, R-Cy-T-Ph-2-Xa-VO-Ph-Z, R-Cy-T-Ph-2-Xa-VO-Ph1-
Z, R-Cy-T-Ph-2-Xa-VO-Ph3-Z, R-Cy-T-Ph-T-Xa-VO-Ph-
Z, R-Cy-T-Ph-T-Xa-VO-Ph1-Z, R-Cy-T-Ph-T-Xa-VO-Ph3-
Z, R-Cy-T-Ph-Xa-VO-Ph-Z, R-Cy-T-Ph-Xa-VO-Ph1-Z, R-
Cy-T-Ph-Xa-VO-Ph3-Z, R-Cy-Ph-2-Xa-VO-Ph-Z, R-Cy-Ph
-2-Xa-VO-Ph1-Z, R-Cy-Ph-2-Xa-VO-Ph3-Z, R-Cy-Ph-TX
a-VO-Ph-Z, R-Cy-Ph-T-Xa-VO-Ph1-Z, R-Cy-Ph-T-Xa-VO-
Ph3-Z, R-Cy-Ph-Xa-VO-Ph-Z, R-Cy-Ph-Xa-VO-Ph1-Z, R-
Cy-Ph-Xa-VO-Ph3-Z, R-Cy-2-Ph-2-Xa-Cy-Z, R-Cy-2-Ph-
2-Xa-Ph-Z, R-Cy-2-Ph-2-Xa-Ph1-Z, R-Cy-2-Ph-2-Xa-Ph
3-Z, R-Cy-2-Ph-T-Xa-Cy-Z, R-Cy-2-Ph-T-Xa-Ph-Z, RC
y-2-Ph-T-Xa-Ph1-Z, R-Cy-2-Ph-T-Xa-Ph3-Z, R-Cy-2-Ph
-Xa-Cy-Z, R-Cy-2-Ph-Xa-Ph-Z, R-Cy-2-Ph-Xa-Ph1-Z, R
-Cy-2-Ph-Xa-Ph3-Z, R-Cy-T-Ph-2-Xa-Cy-Z, R-Cy-T-Ph-
2-Xa-Ph-Z, R-Cy-T-Ph-2-Xa-Ph1-Z, R-Cy-T-Ph-2-Xa-Ph
3-Z, R-Cy-T-Ph-T-Xa-Cy-Z, R-Cy-T-Ph-T-Xa-Ph-Z, RC
yT-Ph-T-Xa-Ph1-Z, R-Cy-T-Ph-T-Xa-Ph3-Z, R-Cy-T-Ph
-Xa-Cy-Z, R-Cy-T-Ph-Xa-Ph-Z, R-Cy-T-Ph-Xa-Ph1-Z, R
-Cy-T-Ph-Xa-Ph3-Z, R-Cy-Ph-2-Xa-Cy-Z, R-Cy-Ph-2-Xa
-Ph-Z, R-Cy-Ph-2-Xa-Ph1-Z, R-Cy-Ph-2-Xa-Ph3-Z,

【００３０】R-Cy-Ph-T-Xa-Cy-Z、R-Cy-Ph-T-Xa-Ph-Z、
R-Cy-Ph-T-Xa-Ph1-Z、R-Cy-Ph-T-Xa-Ph3-Z、R-Cy-Ph-Xa
-Cy-Z、R-Cy-Ph-Xa-Ph-Z、R-Cy-Ph-Xa-Ph1-Z、R-Cy-Ph-
Xa-Ph3-Z、R-Cy-2-Ph1-2-Xa-T-Ph-Z、R-Cy-2-Ph1-2-Xa-
T-Ph1-Z、R-Cy-2-Ph1-2-Xa-T-Ph3-Z、R-Cy-2-Ph1-T-Xa-
T-Ph-Z、R-Cy-2-Ph1-T-Xa-T-Ph1-Z、R-Cy-2-Ph1-T-Xa-T
-Ph3-Z、R-Cy-2-Ph1-Xa-T-Ph-Z、R-Cy-2-Ph1-Xa-T-Ph1-
Z、R-Cy-2-Ph1-Xa-T-Ph3-Z、R-Cy-T-Ph1-2-Xa-T-Ph-Z、
R-Cy-T-Ph1-2-Xa-T-Ph1-Z、R-Cy-T-Ph1-2-Xa-T-Ph3-Z、
R-Cy-T-Ph1-T-Xa-T-Ph-Z、R-Cy-T-Ph1-T-Xa-T-Ph1-Z、R
-Cy-T-Ph1-T-Xa-T-Ph3-Z、R-Cy-T-Ph1-Xa-T-Ph-Z、R-Cy
-T-Ph1-Xa-T-Ph1-Z、R-Cy-T-Ph1-Xa-T-Ph3-Z、R-Cy-Ph1
-2-Xa-T-Ph-Z、R-Cy-Ph1-2-Xa-T-Ph1-Z、R-Cy-Ph1-2-Xa
-T-Ph3-Z、R-Cy-Ph1-T-Xa-T-Ph-Z、R-Cy-Ph1-T-Xa-T-Ph
1-Z、R-Cy-Ph1-T-Xa-T-Ph3-Z、R-Cy-Ph1-Xa-T-Ph-Z、R-
Cy-Ph1-Xa-T-Ph1-Z、R-Cy-Ph1-Xa-T-Ph3-Z、R-Cy-2-Ph1
-2-Xa-VO-Ph-Z、R-Cy-2-Ph1-2-Xa-VO-Ph1-Z、R-Cy-2-Ph
1-2-Xa-VO-Ph3-Z、R-Cy-2-Ph1-T-Xa-VO-Ph-Z、R-Cy-2-P
h1-T-Xa-VO-Ph1-Z、R-Cy-2-Ph1-T-Xa-VO-Ph3-Z、R-Cy-2
-Ph1-Xa-VO-Ph-Z、R-Cy-2-Ph1-Xa-VO-Ph1-Z、R-Cy-2-Ph
1-Xa-VO-Ph3-Z、R-Cy-T-Ph1-2-Xa-VO-Ph-Z、R-Cy-T-Ph1
-2-Xa-VO-Ph1-Z、R-Cy-T-Ph1-2-Xa-VO-Ph3-Z、R-Cy-T-P
h1-T-Xa-VO-Ph-Z、R-Cy-T-Ph1-T-Xa-VO-Ph1-Z、R-Cy-T-
Ph1-T-Xa-VO-Ph3-Z、R-Cy-T-Ph1-Xa-VO-Ph-Z、R-Cy-T-P
h1-Xa-VO-Ph1-Z、R-Cy-T-Ph1-Xa-VO-Ph3-Z、R-Cy-Ph1-2
-Xa-VO-Ph-Z、R-Cy-Ph1-2-Xa-VO-Ph1-Z、R-Cy-Ph1-2-Xa
-VO-Ph3-Z、R-Cy-Ph1-T-Xa-VO-Ph-Z、R-Cy-Ph1-T-Xa-VO
-Ph1-Z、R-Cy-Ph1-T-Xa-VO-Ph3-Z、R-Cy-Ph1-Xa-VO-Ph-
Z、R-Cy-Ph1-Xa-VO-Ph1-Z、R-Cy-Ph1-Xa-VO-Ph3-Z、R-C
y-2-Ph1-2-Xa-Cy-Z、R-Cy-2-Ph1-2-Xa-Ph-Z、R-Cy-2-Ph
1-2-Xa-Ph1-Z、R-Cy-2-Ph1-2-Xa-Ph3-Z、R-Cy-2-Ph1-T-
Xa-Cy-Z、R-Cy-2-Ph1-T-Xa-Ph-Z、R-Cy-2-Ph1-T-Xa-Ph1
-Z、R-Cy-2-Ph1-T-Xa-Ph3-Z、R-Cy-2-Ph1-Xa-Cy-Z、R-C
y-2-Ph1-Xa-Ph-Z、R-Cy-2-Ph1-Xa-Ph1-Z、R-Cy-2-Ph1-X
a-Ph3-Z、R-Cy-T-Ph1-2-Xa-Cy-Z、R-Cy-T-Ph1-2-Xa-Ph-
Z、R-Cy-T-Ph1-2-Xa-Ph1-Z、R-Cy-T-Ph1-2-Xa-Ph3-Z、R
-Cy-T-Ph1-T-Xa-Cy-Z、R-Cy-T-Ph1-T-Xa-Ph-Z、R-Cy-Ph-T-Xa-Cy-Z, R-Cy-Ph-T-Xa-Ph-Z,
R-Cy-Ph-T-Xa-Ph1-Z, R-Cy-Ph-T-Xa-Ph3-Z, R-Cy-Ph-Xa
-Cy-Z, R-Cy-Ph-Xa-Ph-Z, R-Cy-Ph-Xa-Ph1-Z, R-Cy-Ph-
Xa-Ph3-Z, R-Cy-2-Ph1-2-Xa-T-Ph-Z, R-Cy-2-Ph1-2-Xa-
T-Ph1-Z, R-Cy-2-Ph1-2-Xa-T-Ph3-Z, R-Cy-2-Ph1-T-Xa-
T-Ph-Z, R-Cy-2-Ph1-T-Xa-T-Ph1-Z, R-Cy-2-Ph1-T-Xa-T
-Ph3-Z, R-Cy-2-Ph1-Xa-T-Ph-Z, R-Cy-2-Ph1-Xa-T-Ph1-
Z, R-Cy-2-Ph1-Xa-T-Ph3-Z, R-Cy-T-Ph1-2-Xa-T-Ph-Z,
R-Cy-T-Ph1-2-Xa-T-Ph1-Z, R-Cy-T-Ph1-2-Xa-T-Ph3-Z,
R-Cy-T-Ph1-T-Xa-T-Ph-Z, R-Cy-T-Ph1-T-Xa-T-Ph1-Z, R
-Cy-T-Ph1-T-Xa-T-Ph3-Z, R-Cy-T-Ph1-Xa-T-Ph-Z, R-Cy
-T-Ph1-Xa-T-Ph1-Z, R-Cy-T-Ph1-Xa-T-Ph3-Z, R-Cy-Ph1
-2-Xa-T-Ph-Z, R-Cy-Ph1-2-Xa-T-Ph1-Z, R-Cy-Ph1-2-Xa
-T-Ph3-Z, R-Cy-Ph1-T-Xa-T-Ph-Z, R-Cy-Ph1-T-Xa-T-Ph
1-Z, R-Cy-Ph1-T-Xa-T-Ph3-Z, R-Cy-Ph1-Xa-T-Ph-Z, R-
Cy-Ph1-Xa-T-Ph1-Z, R-Cy-Ph1-Xa-T-Ph3-Z, R-Cy-2-Ph1
-2-Xa-VO-Ph-Z, R-Cy-2-Ph1-2-Xa-VO-Ph1-Z, R-Cy-2-Ph
1-2-Xa-VO-Ph3-Z, R-Cy-2-Ph1-T-Xa-VO-Ph-Z, R-Cy-2-P
h1-T-Xa-VO-Ph1-Z, R-Cy-2-Ph1-T-Xa-VO-Ph3-Z, R-Cy-2
-Ph1-Xa-VO-Ph-Z, R-Cy-2-Ph1-Xa-VO-Ph1-Z, R-Cy-2-Ph
1-Xa-VO-Ph3-Z, R-Cy-T-Ph1-2-Xa-VO-Ph-Z, R-Cy-T-Ph1
-2-Xa-VO-Ph1-Z, R-Cy-T-Ph1-2-Xa-VO-Ph3-Z, R-Cy-TP
h1-T-Xa-VO-Ph-Z, R-Cy-T-Ph1-T-Xa-VO-Ph1-Z, R-Cy-T-
Ph1-T-Xa-VO-Ph3-Z, R-Cy-T-Ph1-Xa-VO-Ph-Z, R-Cy-TP
h1-Xa-VO-Ph1-Z, R-Cy-T-Ph1-Xa-VO-Ph3-Z, R-Cy-Ph1-2
-Xa-VO-Ph-Z, R-Cy-Ph1-2-Xa-VO-Ph1-Z, R-Cy-Ph1-2-Xa
-VO-Ph3-Z, R-Cy-Ph1-T-Xa-VO-Ph-Z, R-Cy-Ph1-T-Xa-VO
-Ph1-Z, R-Cy-Ph1-T-Xa-VO-Ph3-Z, R-Cy-Ph1-Xa-VO-Ph-
Z, R-Cy-Ph1-Xa-VO-Ph1-Z, R-Cy-Ph1-Xa-VO-Ph3-Z, RC
y-2-Ph1-2-Xa-Cy-Z, R-Cy-2-Ph1-2-Xa-Ph-Z, R-Cy-2-Ph
1-2-Xa-Ph1-Z, R-Cy-2-Ph1-2-Xa-Ph3-Z, R-Cy-2-Ph1-T-
Xa-Cy-Z, R-Cy-2-Ph1-T-Xa-Ph-Z, R-Cy-2-Ph1-T-Xa-Ph1
-Z, R-Cy-2-Ph1-T-Xa-Ph3-Z, R-Cy-2-Ph1-Xa-Cy-Z, RC
y-2-Ph1-Xa-Ph-Z, R-Cy-2-Ph1-Xa-Ph1-Z, R-Cy-2-Ph1-X
a-Ph3-Z, R-Cy-T-Ph1-2-Xa-Cy-Z, R-Cy-T-Ph1-2-Xa-Ph-
Z, R-Cy-T-Ph1-2-Xa-Ph1-Z, R-Cy-T-Ph1-2-Xa-Ph3-Z, R
-Cy-T-Ph1-T-Xa-Cy-Z, R-Cy-T-Ph1-T-Xa-Ph-Z,

【００３１】R-Cy-T-Ph1-T-Xa-Ph1-Z、R-Cy-T-Ph1-T-Xa
-Ph3-Z、R-Cy-T-Ph1-Xa-Cy-Z、R-Cy-T-Ph1-Xa-Ph-Z、R-
Cy-T-Ph1-Xa-Ph1-Z、R-Cy-T-Ph1-Xa-Ph3-Z、R-Cy-Ph1-2
-Xa-Cy-Z、R-Cy-Ph1-2-Xa-Ph-Z、R-Cy-Ph1-2-Xa-Ph1-
Z、R-Cy-Ph1-2-Xa-Ph3-Z、R-Cy-Ph1-T-Xa-Cy-Z、R-Cy-P
h1-T-Xa-Ph-Z、R-Cy-Ph1-T-Xa-Ph1-Z、R-Cy-Ph1-T-Xa-P
h3-Z、R-Cy-Ph1-Xa-Cy-Z、R-Cy-Ph1-Xa-Ph-Z、R-Cy-Ph1
-Xa-Ph1-Z、R-Cy-Ph1-Xa-Ph3-Z、R-Cy-T-Ph3-2-Xa-T-Ph
-Z、R-Cy-T-Ph3-2-Xa-T-Ph1-Z、R-Cy-T-Ph3-2-Xa-T-Ph3
-Z、R-Cy-T-Ph3-T-Xa-T-Ph-Z、R-Cy-T-Ph3-T-Xa-T-Ph1-
Z、R-Cy-T-Ph3-T-Xa-T-Ph3-Z、R-Cy-T-Ph3-Xa-T-Ph-Z、
R-Cy-T-Ph3-Xa-T-Ph1-Z、R-Cy-T-Ph3-Xa-T-Ph3-Z、R-Cy
-Ph3-2-Xa-T-Ph-Z、R-Cy-Ph3-2-Xa-T-Ph1-Z、R-Cy-Ph3-
2-Xa-T-Ph3-Z、R-Cy-Ph3-T-Xa-T-Ph-Z、R-Cy-Ph3-T-Xa-
T-Ph1-Z、R-Cy-Ph3-T-Xa-T-Ph3-Z、R-Cy-Ph3-Xa-T-Ph-
Z、R-Cy-Ph3-Xa-T-Ph1-Z、R-Cy-Ph3-Xa-T-Ph3-Z、R-Cy-
T-Ph3-2-Xa-VO-Ph-Z、R-Cy-T-Ph3-2-Xa-VO-Ph1-Z、R-Cy
-T-Ph3-2-Xa-VO-Ph3-Z、R-Cy-T-Ph3-T-Xa-VO-Ph-Z、R-C
y-T-Ph3-T-Xa-VO-Ph1-Z、R-Cy-T-Ph3-T-Xa-VO-Ph3-Z、R
-Cy-T-Ph3-Xa-VO-Ph-Z、R-Cy-T-Ph3-Xa-VO-Ph1-Z、R-Cy
-T-Ph3-Xa-VO-Ph3-Z、R-Cy-Ph3-2-Xa-VO-Ph-Z、R-Cy-Ph
3-2-Xa-VO-Ph1-Z、R-Cy-Ph3-2-Xa-VO-Ph3-Z、R-Cy-Ph3-
T-Xa-VO-Ph-Z、R-Cy-Ph3-T-Xa-VO-Ph1-Z、R-Cy-Ph3-T-X
a-VO-Ph3-Z、R-Cy-Ph3-Xa-VO-Ph-Z、R-Cy-Ph3-Xa-VO-Ph
1-Z、R-Cy-Ph3-Xa-VO-Ph3-Z、R-Cy-T-Ph3-2-Xa-Cy-Z、R
-Cy-T-Ph3-2-Xa-Ph-Z、R-Cy-T-Ph3-2-Xa-Ph1-Z、R-Cy-T
-Ph3-2-Xa-Ph3-Z、R-Cy-T-Ph3-T-Xa-Cy-Z、R-Cy-T-Ph3-
T-Xa-Ph-Z、R-Cy-T-Ph3-T-Xa-Ph1-Z、R-Cy-T-Ph3-T-Xa-
Ph3-Z、R-Cy-T-Ph3-Xa-Cy-Z、R-Cy-T-Ph3-Xa-Ph-Z、R-C
y-T-Ph3-Xa-Ph1-Z、R-Cy-T-Ph3-Xa-Ph3-Z、R-Cy-Ph3-2-
Xa-Cy-Z、R-Cy-Ph3-2-Xa-Ph-Z、R-Cy-Ph3-2-Xa-Ph1-Z、
R-Cy-Ph3-2-Xa-Ph3-Z、R-Cy-Ph3-T-Xa-Cy-Z、R-Cy-Ph3-
T-Xa-Ph-Z、R-Cy-Ph3-T-Xa-Ph1-Z、R-Cy-Ph3-T-Xa-Ph3-
Z、R-Cy-Ph3-Xa-Cy-Z、R-Cy-Ph3-Xa-Ph-Z、R-Cy-Ph3-Xa
-Ph1-Z、R-Cy-Ph3-Xa-Ph3-ZR-Cy-T-Ph1-T-Xa-Ph1-Z, R-Cy-T-Ph1-T-Xa
-Ph3-Z, R-Cy-T-Ph1-Xa-Cy-Z, R-Cy-T-Ph1-Xa-Ph-Z, R-
Cy-T-Ph1-Xa-Ph1-Z, R-Cy-T-Ph1-Xa-Ph3-Z, R-Cy-Ph1-2
-Xa-Cy-Z, R-Cy-Ph1-2-Xa-Ph-Z, R-Cy-Ph1-2-Xa-Ph1-
Z, R-Cy-Ph1-2-Xa-Ph3-Z, R-Cy-Ph1-T-Xa-Cy-Z, R-Cy-P
h1-T-Xa-Ph-Z, R-Cy-Ph1-T-Xa-Ph1-Z, R-Cy-Ph1-T-Xa-P
h3-Z, R-Cy-Ph1-Xa-Cy-Z, R-Cy-Ph1-Xa-Ph-Z, R-Cy-Ph1
-Xa-Ph1-Z, R-Cy-Ph1-Xa-Ph3-Z, R-Cy-T-Ph3-2-Xa-T-Ph
-Z, R-Cy-T-Ph3-2-Xa-T-Ph1-Z, R-Cy-T-Ph3-2-Xa-T-Ph3
-Z, R-Cy-T-Ph3-T-Xa-T-Ph-Z, R-Cy-T-Ph3-T-Xa-T-Ph1-
Z, R-Cy-T-Ph3-T-Xa-T-Ph3-Z, R-Cy-T-Ph3-Xa-T-Ph-Z,
R-Cy-T-Ph3-Xa-T-Ph1-Z, R-Cy-T-Ph3-Xa-T-Ph3-Z, R-Cy
-Ph3-2-Xa-T-Ph-Z, R-Cy-Ph3-2-Xa-T-Ph1-Z, R-Cy-Ph3-
2-Xa-T-Ph3-Z, R-Cy-Ph3-T-Xa-T-Ph-Z, R-Cy-Ph3-T-Xa-
T-Ph1-Z, R-Cy-Ph3-T-Xa-T-Ph3-Z, R-Cy-Ph3-Xa-T-Ph-
Z, R-Cy-Ph3-Xa-T-Ph1-Z, R-Cy-Ph3-Xa-T-Ph3-Z, R-Cy-
T-Ph3-2-Xa-VO-Ph-Z, R-Cy-T-Ph3-2-Xa-VO-Ph1-Z, R-Cy
-T-Ph3-2-Xa-VO-Ph3-Z, R-Cy-T-Ph3-T-Xa-VO-Ph-Z, RC
yT-Ph3-T-Xa-VO-Ph1-Z, R-Cy-T-Ph3-T-Xa-VO-Ph3-Z, R
-Cy-T-Ph3-Xa-VO-Ph-Z, R-Cy-T-Ph3-Xa-VO-Ph1-Z, R-Cy
-T-Ph3-Xa-VO-Ph3-Z, R-Cy-Ph3-2-Xa-VO-Ph-Z, R-Cy-Ph
3-2-Xa-VO-Ph1-Z, R-Cy-Ph3-2-Xa-VO-Ph3-Z, R-Cy-Ph3-
T-Xa-VO-Ph-Z, R-Cy-Ph3-T-Xa-VO-Ph1-Z, R-Cy-Ph3-TX
a-VO-Ph3-Z, R-Cy-Ph3-Xa-VO-Ph-Z, R-Cy-Ph3-Xa-VO-Ph
1-Z, R-Cy-Ph3-Xa-VO-Ph3-Z, R-Cy-T-Ph3-2-Xa-Cy-Z, R
-Cy-T-Ph3-2-Xa-Ph-Z, R-Cy-T-Ph3-2-Xa-Ph1-Z, R-Cy-T
-Ph3-2-Xa-Ph3-Z, R-Cy-T-Ph3-T-Xa-Cy-Z, R-Cy-T-Ph3-
T-Xa-Ph-Z, R-Cy-T-Ph3-T-Xa-Ph1-Z, R-Cy-T-Ph3-T-Xa-
Ph3-Z, R-Cy-T-Ph3-Xa-Cy-Z, R-Cy-T-Ph3-Xa-Ph-Z, RC
yT-Ph3-Xa-Ph1-Z, R-Cy-T-Ph3-Xa-Ph3-Z, R-Cy-Ph3-2-
Xa-Cy-Z, R-Cy-Ph3-2-Xa-Ph-Z, R-Cy-Ph3-2-Xa-Ph1-Z,
R-Cy-Ph3-2-Xa-Ph3-Z, R-Cy-Ph3-T-Xa-Cy-Z, R-Cy-Ph3-
T-Xa-Ph-Z, R-Cy-Ph3-T-Xa-Ph1-Z, R-Cy-Ph3-T-Xa-Ph3-
Z, R-Cy-Ph3-Xa-Cy-Z, R-Cy-Ph3-Xa-Ph-Z, R-Cy-Ph3-Xa
-Ph1-Z, R-Cy-Ph3-Xa-Ph3-Z

【００３２】R-Ph-2-Cy-2-Xa-T-Ph-Z、R-Ph-2-Cy-2-Xa-
T-Ph1-Z、R-Ph-2-Cy-2-Xa-T-Ph3-Z、R-Ph-2-Cy-J-Xa-T-
Ph-Z、R-Ph-2-Cy-J-Xa-T-Ph1-Z、R-Ph-2-Cy-J-Xa-T-Ph3
-Z、R-Ph-2-Cy-Xa-T-Ph-Z、R-Ph-2-Cy-Xa-T-Ph1-Z、R-P
h-2-Cy-Xa-T-Ph3-Z、R-Ph-Cy-2-Xa-T-Ph-Z、R-Ph-Cy-2-
Xa-T-Ph1-Z、R-Ph-Cy-2-Xa-T-Ph3-Z、R-Ph-Cy-J-Xa-T-P
h-Z、R-Ph-Cy-J-Xa-T-Ph1-Z、R-Ph-Cy-J-Xa-T-Ph3-Z、R
-Ph-Cy-Xa-T-Ph-Z、R-Ph-Cy-Xa-T-Ph1-Z、R-Ph-Cy-Xa-T
-Ph3-Z、R-Ph-2-Cy-2-Xa-VO-Ph-Z、R-Ph-2-Cy-2-Xa-VO-
Ph1-Z、R-Ph-2-Cy-2-Xa-VO-Ph3-Z、R-Ph-2-Cy-J-Xa-VO-
Ph-Z、R-Ph-2-Cy-J-Xa-VO-Ph1-Z、R-Ph-2-Cy-J-Xa-VO-P
h3-Z、R-Ph-2-Cy-Xa-VO-Ph-Z、R-Ph-2-Cy-Xa-VO-Ph1-
Z、R-Ph-2-Cy-Xa-VO-Ph3-Z、R-Ph-Cy-2-Xa-VO-Ph-Z、R-
Ph-Cy-2-Xa-VO-Ph1-Z、R-Ph-Cy-2-Xa-VO-Ph3-Z、R-Ph-C
y-J-Xa-VO-Ph-Z、R-Ph-Cy-J-Xa-VO-Ph1-Z、R-Ph-Cy-J-X
a-VO-Ph3-Z、R-Ph-Cy-Xa-VO-Ph-Z、R-Ph-Cy-Xa-VO-Ph1-
Z、R-Ph-Cy-Xa-VO-Ph3-Z、R-Ph-2-Cy-2-Xa-Cy-Z、R-Ph-
2-Cy-2-Xa-Ph-Z、R-Ph-2-Cy-2-Xa-Ph1-Z、R-Ph-2-Cy-2-
Xa-Ph3-Z、R-Ph-2-Cy-J-Xa-Cy-Z、R-Ph-2-Cy-J-Xa-Ph-
Z、R-Ph-2-Cy-J-Xa-Ph1-Z、R-Ph-2-Cy-J-Xa-Ph3-Z、R-P
h-2-Cy-Xa-Cy-Z、R-Ph-2-Cy-Xa-Ph-Z、R-Ph-2-Cy-Xa-Ph
1-Z、R-Ph-2-Cy-Xa-Ph3-Z、R-Ph-Cy-2-Xa-Cy-Z、R-Ph-C
y-2-Xa-Ph-Z、R-Ph-Cy-2-Xa-Ph1-Z、R-Ph-Cy-2-Xa-Ph3-
Z、R-Ph-Cy-J-Xa-Cy-Z、R-Ph-Cy-J-Xa-Ph-Z、R-Ph-Cy-J
-Xa-Ph1-Z、R-Ph-Cy-J-Xa-Ph3-Z、R-Ph-Cy-Xa-Cy-Z、R-
Ph-Cy-Xa-Ph-Z、R-Ph-Cy-Xa-Ph1-Z、R-Ph-Cy-Xa-Ph3-
Z、R-Ph-T-Ph-2-Xa-T-Ph-Z、R-Ph-T-Ph-2-Xa-T-Ph1-Z、
R-Ph-T-Ph-2-Xa-T-Ph3-Z、R-Ph-T-Ph-T-Xa-T-Ph-Z、R-P
h-T-Ph-T-Xa-T-Ph1-Z、R-Ph-T-Ph-T-Xa-T-Ph3-Z、R-Ph-
T-Ph-Xa-T-Ph-Z、R-Ph-T-Ph-Xa-T-Ph1-Z、R-Ph-T-Ph-Xa
-T-Ph3-Z、R-Ph-Ph-2-Xa-T-Ph-Z、R-Ph-Ph-2-Xa-T-Ph1-
Z、R-Ph-Ph-2-Xa-T-Ph3-Z、R-Ph-Ph-T-Xa-T-Ph-Z、R-Ph
-Ph-T-Xa-T-Ph1-Z、R-Ph-Ph-T-Xa-T-Ph3-Z、R-Ph-Ph-Xa
-T-Ph-Z、R-Ph-Ph-Xa-T-Ph1-Z、R-Ph-Ph-Xa-T-Ph3-Z、R
-Ph-T-Ph-2-Xa-VO-Ph-Z、R-Ph-T-Ph-2-Xa-VO-Ph1-Z、R-
Ph-T-Ph-2-Xa-VO-Ph3-Z、R-Ph-T-Ph-T-Xa-VO-Ph-Z、R-P
h-T-Ph-T-Xa-VO-Ph1-Z、R-Ph-T-Ph-T-Xa-VO-Ph3-Z、R-P
h-T-Ph-Xa-VO-Ph-Z、R-Ph-T-Ph-Xa-VO-Ph1-Z、R-Ph-T-P
h-Xa-VO-Ph3-Z、R-Ph-Ph-2-Xa-VO-Ph-Z、R-Ph-Ph-2-Xa-
VO-Ph1-Z、R-Ph-2-Cy-2-Xa-T-Ph-Z, R-Ph-2-Cy-2-Xa-
T-Ph1-Z, R-Ph-2-Cy-2-Xa-T-Ph3-Z, R-Ph-2-Cy-J-Xa-T-
Ph-Z, R-Ph-2-Cy-J-Xa-T-Ph1-Z, R-Ph-2-Cy-J-Xa-T-Ph3
-Z, R-Ph-2-Cy-Xa-T-Ph-Z, R-Ph-2-Cy-Xa-T-Ph1-Z, RP
h-2-Cy-Xa-T-Ph3-Z, R-Ph-Cy-2-Xa-T-Ph-Z, R-Ph-Cy-2-
Xa-T-Ph1-Z, R-Ph-Cy-2-Xa-T-Ph3-Z, R-Ph-Cy-J-Xa-TP
hZ, R-Ph-Cy-J-Xa-T-Ph1-Z, R-Ph-Cy-J-Xa-T-Ph3-Z, R
-Ph-Cy-Xa-T-Ph-Z, R-Ph-Cy-Xa-T-Ph1-Z, R-Ph-Cy-Xa-T
-Ph3-Z, R-Ph-2-Cy-2-Xa-VO-Ph-Z, R-Ph-2-Cy-2-Xa-VO-
Ph1-Z, R-Ph-2-Cy-2-Xa-VO-Ph3-Z, R-Ph-2-Cy-J-Xa-VO-
Ph-Z, R-Ph-2-Cy-J-Xa-VO-Ph1-Z, R-Ph-2-Cy-J-Xa-VO-P
h3-Z, R-Ph-2-Cy-Xa-VO-Ph-Z, R-Ph-2-Cy-Xa-VO-Ph1-
Z, R-Ph-2-Cy-Xa-VO-Ph3-Z, R-Ph-Cy-2-Xa-VO-Ph-Z, R-
Ph-Cy-2-Xa-VO-Ph1-Z, R-Ph-Cy-2-Xa-VO-Ph3-Z, R-Ph-C
yJ-Xa-VO-Ph-Z, R-Ph-Cy-J-Xa-VO-Ph1-Z, R-Ph-Cy-JX
a-VO-Ph3-Z, R-Ph-Cy-Xa-VO-Ph-Z, R-Ph-Cy-Xa-VO-Ph1-
Z, R-Ph-Cy-Xa-VO-Ph3-Z, R-Ph-2-Cy-2-Xa-Cy-Z, R-Ph-
2-Cy-2-Xa-Ph-Z, R-Ph-2-Cy-2-Xa-Ph1-Z, R-Ph-2-Cy-2-
Xa-Ph3-Z, R-Ph-2-Cy-J-Xa-Cy-Z, R-Ph-2-Cy-J-Xa-Ph-
Z, R-Ph-2-Cy-J-Xa-Ph1-Z, R-Ph-2-Cy-J-Xa-Ph3-Z, RP
h-2-Cy-Xa-Cy-Z, R-Ph-2-Cy-Xa-Ph-Z, R-Ph-2-Cy-Xa-Ph
1-Z, R-Ph-2-Cy-Xa-Ph3-Z, R-Ph-Cy-2-Xa-Cy-Z, R-Ph-C
y-2-Xa-Ph-Z, R-Ph-Cy-2-Xa-Ph1-Z, R-Ph-Cy-2-Xa-Ph3-
Z, R-Ph-Cy-J-Xa-Cy-Z, R-Ph-Cy-J-Xa-Ph-Z, R-Ph-Cy-J
-Xa-Ph1-Z, R-Ph-Cy-J-Xa-Ph3-Z, R-Ph-Cy-Xa-Cy-Z, R-
Ph-Cy-Xa-Ph-Z, R-Ph-Cy-Xa-Ph1-Z, R-Ph-Cy-Xa-Ph3-
Z, R-Ph-T-Ph-2-Xa-T-Ph-Z, R-Ph-T-Ph-2-Xa-T-Ph1-Z,
R-Ph-T-Ph-2-Xa-T-Ph3-Z, R-Ph-T-Ph-T-Xa-T-Ph-Z, RP
hT-Ph-T-Xa-T-Ph1-Z, R-Ph-T-Ph-T-Xa-T-Ph3-Z, R-Ph-
T-Ph-Xa-T-Ph-Z, R-Ph-T-Ph-Xa-T-Ph1-Z, R-Ph-T-Ph-Xa
-T-Ph3-Z, R-Ph-Ph-2-Xa-T-Ph-Z, R-Ph-Ph-2-Xa-T-Ph1-
Z, R-Ph-Ph-2-Xa-T-Ph3-Z, R-Ph-Ph-T-Xa-T-Ph-Z, R-Ph
-Ph-T-Xa-T-Ph1-Z, R-Ph-Ph-T-Xa-T-Ph3-Z, R-Ph-Ph-Xa
-T-Ph-Z, R-Ph-Ph-Xa-T-Ph1-Z, R-Ph-Ph-Xa-T-Ph3-Z, R
-Ph-T-Ph-2-Xa-VO-Ph-Z, R-Ph-T-Ph-2-Xa-VO-Ph1-Z, R-
Ph-T-Ph-2-Xa-VO-Ph3-Z, R-Ph-T-Ph-T-Xa-VO-Ph-Z, RP
hT-Ph-T-Xa-VO-Ph1-Z, R-Ph-T-Ph-T-Xa-VO-Ph3-Z, RP
hT-Ph-Xa-VO-Ph-Z, R-Ph-T-Ph-Xa-VO-Ph1-Z, R-Ph-TP
h-Xa-VO-Ph3-Z, R-Ph-Ph-2-Xa-VO-Ph-Z, R-Ph-Ph-2-Xa-
VO-Ph1-Z,

【００３３】R-Ph-Ph-2-Xa-VO-Ph3-Z、R-Ph-Ph-T-Xa-VO
-Ph-Z、R-Ph-Ph-T-Xa-VO-Ph1-Z、R-Ph-Ph-T-Xa-VO-Ph3-
Z、R-Ph-Ph-Xa-VO-Ph-Z、R-Ph-Ph-Xa-VO-Ph1-Z、R-Ph-P
h-Xa-VO-Ph3-Z、R-Ph-T-Ph-2-Xa-Cy-Z、R-Ph-T-Ph-2-Xa
-Ph-Z、R-Ph-T-Ph-2-Xa-Ph1-Z、R-Ph-T-Ph-2-Xa-Ph3-
Z、R-Ph-T-Ph-T-Xa-Cy-Z、R-Ph-T-Ph-T-Xa-Ph-Z、R-Ph-
T-Ph-T-Xa-Ph1-Z、R-Ph-T-Ph-T-Xa-Ph3-Z、R-Ph-T-Ph-X
a-Cy-Z、R-Ph-T-Ph-Xa-Ph-Z、R-Ph-T-Ph-Xa-Ph1-Z、R-P
h-T-Ph-Xa-Ph3-Z、R-Ph-Ph-2-Xa-Cy-Z、R-Ph-Ph-2-Xa-P
h-Z、R-Ph-Ph-2-Xa-Ph1-Z、R-Ph-Ph-2-Xa-Ph3-Z、R-Ph-
Ph-T-Xa-Cy-Z、R-Ph-Ph-T-Xa-Ph-Z、R-Ph-Ph-T-Xa-Ph1-
Z、R-Ph-Ph-T-Xa-Ph3-Z、R-Ph-Ph-Xa-Cy-Z、R-Ph-Ph-Xa
-Ph-Z、R-Ph-Ph-Xa-Ph1-Z、R-Ph-Ph-Xa-Ph3-Z、R-Ph-T-
Ph1-2-Xa-T-Ph-Z、R-Ph-T-Ph1-2-Xa-T-Ph1-Z、R-Ph-T-P
h1-2-Xa-T-Ph3-Z、R-Ph-T-Ph1-T-Xa-T-Ph-Z、R-Ph-T-Ph
1-T-Xa-T-Ph1-Z、R-Ph-T-Ph1-T-Xa-T-Ph3-Z、R-Ph-T-Ph
1-Xa-T-Ph-Z、R-Ph-T-Ph1-Xa-T-Ph1-Z、R-Ph-T-Ph1-Xa-
T-Ph3-Z、R-Ph-Ph1-2-Xa-T-Ph-Z、R-Ph-Ph1-2-Xa-T-Ph1
-Z、R-Ph-Ph1-2-Xa-T-Ph3-Z、R-Ph-Ph1-T-Xa-T-Ph-Z、R
-Ph-Ph1-T-Xa-T-Ph1-Z、R-Ph-Ph1-T-Xa-T-Ph3-Z、R-Ph-
Ph1-Xa-T-Ph-Z、R-Ph-Ph1-Xa-T-Ph1-Z、R-Ph-Ph1-Xa-T-
Ph3-Z、R-Ph-T-Ph1-2-Xa-VO-Ph-Z、R-Ph-T-Ph1-2-Xa-VO
-Ph1-Z、R-Ph-T-Ph1-2-Xa-VO-Ph3-Z、R-Ph-T-Ph1-T-Xa-
VO-Ph-Z、R-Ph-T-Ph1-T-Xa-VO-Ph1-Z、R-Ph-T-Ph1-T-Xa
-VO-Ph3-Z、R-Ph-T-Ph1-Xa-VO-Ph-Z、R-Ph-T-Ph1-Xa-VO
-Ph1-Z、R-Ph-T-Ph1-Xa-VO-Ph3-Z、R-Ph-Ph1-2-Xa-VO-P
h-Z、R-Ph-Ph1-2-Xa-VO-Ph1-Z、R-Ph-Ph1-2-Xa-VO-Ph3-
Z、R-Ph-Ph1-T-Xa-VO-Ph-Z、R-Ph-Ph1-T-Xa-VO-Ph1-Z、
R-Ph-Ph1-T-Xa-VO-Ph3-Z、R-Ph-Ph1-Xa-VO-Ph-Z、R-Ph-
Ph1-Xa-VO-Ph1-Z、R-Ph-Ph1-Xa-VO-Ph3-Z、R-Ph-T-Ph1-
2-Xa-Cy-Z、R-Ph-T-Ph1-2-Xa-Ph-Z、R-Ph-T-Ph1-2-Xa-P
h1-Z、R-Ph-T-Ph1-2-Xa-Ph3-Z、R-Ph-T-Ph1-T-Xa-Cy-
Z、R-Ph-T-Ph1-T-Xa-Ph-Z、R-Ph-T-Ph1-T-Xa-Ph1-Z、R-
Ph-T-Ph1-T-Xa-Ph3-Z、R-Ph-T-Ph1-Xa-Cy-Z、R-Ph-T-Ph
1-Xa-Ph-Z、R-Ph-T-Ph1-Xa-Ph1-Z、R-Ph-T-Ph1-Xa-Ph3-
Z、R-Ph-Ph1-2-Xa-Cy-Z、R-Ph-Ph1-2-Xa-Ph-Z、R-Ph-Ph
1-2-Xa-Ph1-Z、R-Ph-Ph1-2-Xa-Ph3-Z、R-Ph-Ph1-T-Xa-C
y-Z、R-Ph-Ph1-T-Xa-Ph-Z、R-Ph-Ph1-T-Xa-Ph1-Z、R-Ph
-Ph1-T-Xa-Ph3-Z、R-Ph-Ph1-Xa-Cy-Z、R-Ph-Ph1-Xa-Ph-
Z、R-Ph-Ph1-Xa-Ph1-Z、R-Ph-Ph1-Xa-Ph3-Z、R-Ph-T-Ph
3-2-Xa-T-Ph-Z、R-Ph-T-Ph3-2-Xa-T-Ph1-Z、R-Ph-T-Ph3
-2-Xa-T-Ph3-Z、R-Ph-T-Ph3-T-Xa-T-Ph-Z、R-Ph-T-Ph3-
T-Xa-T-Ph1-Z、R-Ph-T-Ph3-T-Xa-T-Ph3-Z、R-Ph-T-Ph3-
Xa-T-Ph-Z、R-Ph-T-Ph3-Xa-T-Ph1-Z、R-Ph-T-Ph3-Xa-T-
Ph3-Z、R-Ph-Ph3-2-Xa-T-Ph-Z、R-Ph-Ph-2-Xa-VO-Ph3-Z, R-Ph-Ph-T-Xa-VO
-Ph-Z, R-Ph-Ph-T-Xa-VO-Ph1-Z, R-Ph-Ph-T-Xa-VO-Ph3-
Z, R-Ph-Ph-Xa-VO-Ph-Z, R-Ph-Ph-Xa-VO-Ph1-Z, R-Ph-P
h-Xa-VO-Ph3-Z, R-Ph-T-Ph-2-Xa-Cy-Z, R-Ph-T-Ph-2-Xa
-Ph-Z, R-Ph-T-Ph-2-Xa-Ph1-Z, R-Ph-T-Ph-2-Xa-Ph3-
Z, R-Ph-T-Ph-T-Xa-Cy-Z, R-Ph-T-Ph-T-Xa-Ph-Z, R-Ph-
T-Ph-T-Xa-Ph1-Z, R-Ph-T-Ph-T-Xa-Ph3-Z, R-Ph-T-Ph-X
a-Cy-Z, R-Ph-T-Ph-Xa-Ph-Z, R-Ph-T-Ph-Xa-Ph1-Z, RP
hT-Ph-Xa-Ph3-Z, R-Ph-Ph-2-Xa-Cy-Z, R-Ph-Ph-2-Xa-P
hZ, R-Ph-Ph-2-Xa-Ph1-Z, R-Ph-Ph-2-Xa-Ph3-Z, R-Ph-
Ph-T-Xa-Cy-Z, R-Ph-Ph-T-Xa-Ph-Z, R-Ph-Ph-T-Xa-Ph1-
Z, R-Ph-Ph-T-Xa-Ph3-Z, R-Ph-Ph-Xa-Cy-Z, R-Ph-Ph-Xa
-Ph-Z, R-Ph-Ph-Xa-Ph1-Z, R-Ph-Ph-Xa-Ph3-Z, R-Ph-T-
Ph1-2-Xa-T-Ph-Z, R-Ph-T-Ph1-2-Xa-T-Ph1-Z, R-Ph-TP
h1-2-Xa-T-Ph3-Z, R-Ph-T-Ph1-T-Xa-T-Ph-Z, R-Ph-T-Ph
1-T-Xa-T-Ph1-Z, R-Ph-T-Ph1-T-Xa-T-Ph3-Z, R-Ph-T-Ph
1-Xa-T-Ph-Z, R-Ph-T-Ph1-Xa-T-Ph1-Z, R-Ph-T-Ph1-Xa-
T-Ph3-Z, R-Ph-Ph1-2-Xa-T-Ph-Z, R-Ph-Ph1-2-Xa-T-Ph1
-Z, R-Ph-Ph1-2-Xa-T-Ph3-Z, R-Ph-Ph1-T-Xa-T-Ph-Z, R
-Ph-Ph1-T-Xa-T-Ph1-Z, R-Ph-Ph1-T-Xa-T-Ph3-Z, R-Ph-
Ph1-Xa-T-Ph-Z, R-Ph-Ph1-Xa-T-Ph1-Z, R-Ph-Ph1-Xa-T-
Ph3-Z, R-Ph-T-Ph1-2-Xa-VO-Ph-Z, R-Ph-T-Ph1-2-Xa-VO
-Ph1-Z, R-Ph-T-Ph1-2-Xa-VO-Ph3-Z, R-Ph-T-Ph1-T-Xa-
VO-Ph-Z, R-Ph-T-Ph1-T-Xa-VO-Ph1-Z, R-Ph-T-Ph1-T-Xa
-VO-Ph3-Z, R-Ph-T-Ph1-Xa-VO-Ph-Z, R-Ph-T-Ph1-Xa-VO
-Ph1-Z, R-Ph-T-Ph1-Xa-VO-Ph3-Z, R-Ph-Ph1-2-Xa-VO-P
hZ, R-Ph-Ph1-2-Xa-VO-Ph1-Z, R-Ph-Ph1-2-Xa-VO-Ph3-
Z, R-Ph-Ph1-T-Xa-VO-Ph-Z, R-Ph-Ph1-T-Xa-VO-Ph1-Z,
R-Ph-Ph1-T-Xa-VO-Ph3-Z, R-Ph-Ph1-Xa-VO-Ph-Z, R-Ph-
Ph1-Xa-VO-Ph1-Z, R-Ph-Ph1-Xa-VO-Ph3-Z, R-Ph-T-Ph1-
2-Xa-Cy-Z, R-Ph-T-Ph1-2-Xa-Ph-Z, R-Ph-T-Ph1-2-Xa-P
h1-Z, R-Ph-T-Ph1-2-Xa-Ph3-Z, R-Ph-T-Ph1-T-Xa-Cy-
Z, R-Ph-T-Ph1-T-Xa-Ph-Z, R-Ph-T-Ph1-T-Xa-Ph1-Z, R-
Ph-T-Ph1-T-Xa-Ph3-Z, R-Ph-T-Ph1-Xa-Cy-Z, R-Ph-T-Ph
1-Xa-Ph-Z, R-Ph-T-Ph1-Xa-Ph1-Z, R-Ph-T-Ph1-Xa-Ph3-
Z, R-Ph-Ph1-2-Xa-Cy-Z, R-Ph-Ph1-2-Xa-Ph-Z, R-Ph-Ph
1-2-Xa-Ph1-Z, R-Ph-Ph1-2-Xa-Ph3-Z, R-Ph-Ph1-T-Xa-C
yZ, R-Ph-Ph1-T-Xa-Ph-Z, R-Ph-Ph1-T-Xa-Ph1-Z, R-Ph
-Ph1-T-Xa-Ph3-Z, R-Ph-Ph1-Xa-Cy-Z, R-Ph-Ph1-Xa-Ph-
Z, R-Ph-Ph1-Xa-Ph1-Z, R-Ph-Ph1-Xa-Ph3-Z, R-Ph-T-Ph
3-2-Xa-T-Ph-Z, R-Ph-T-Ph3-2-Xa-T-Ph1-Z, R-Ph-T-Ph3
-2-Xa-T-Ph3-Z, R-Ph-T-Ph3-T-Xa-T-Ph-Z, R-Ph-T-Ph3-
T-Xa-T-Ph1-Z, R-Ph-T-Ph3-T-Xa-T-Ph3-Z, R-Ph-T-Ph3-
Xa-T-Ph-Z, R-Ph-T-Ph3-Xa-T-Ph1-Z, R-Ph-T-Ph3-Xa-T-
Ph3-Z, R-Ph-Ph3-2-Xa-T-Ph-Z,

【００３４】R-Ph-Ph3-2-Xa-T-Ph1-Z、R-Ph-Ph3-2-Xa-T
-Ph3-Z、R-Ph-Ph3-T-Xa-T-Ph-Z、R-Ph-Ph3-T-Xa-T-Ph1-
Z、R-Ph-Ph3-T-Xa-T-Ph3-Z、R-Ph-Ph3-Xa-T-Ph-Z、R-Ph
-Ph3-Xa-T-Ph1-Z、R-Ph-Ph3-Xa-T-Ph3-Z、R-Ph-T-Ph3-2
-Xa-VO-Ph-Z、R-Ph-T-Ph3-2-Xa-VO-Ph1-Z、R-Ph-T-Ph3-
2-Xa-VO-Ph3-Z、R-Ph-T-Ph3-T-Xa-VO-Ph-Z、R-Ph-T-Ph3
-T-Xa-VO-Ph1-Z、R-Ph-T-Ph3-T-Xa-VO-Ph3-Z、R-Ph-T-P
h3-Xa-VO-Ph-Z、R-Ph-T-Ph3-Xa-VO-Ph1-Z、R-Ph-T-Ph3-
Xa-VO-Ph3-Z、R-Ph-Ph3-2-Xa-VO-Ph-Z、R-Ph-Ph3-2-Xa-
VO-Ph1-Z、R-Ph-Ph3-2-Xa-VO-Ph3-Z、R-Ph-Ph3-T-Xa-VO
-Ph-Z、R-Ph-Ph3-T-Xa-VO-Ph1-Z、R-Ph-Ph3-T-Xa-VO-Ph
3-Z、R-Ph-Ph3-Xa-VO-Ph-Z、R-Ph-Ph3-Xa-VO-Ph1-Z、R-
Ph-Ph3-Xa-VO-Ph3-Z、R-Ph-T-Ph3-2-Xa-Cy-Z、R-Ph-T-P
h3-2-Xa-Ph-Z、R-Ph-T-Ph3-2-Xa-Ph1-Z、R-Ph-T-Ph3-2-
Xa-Ph3-Z、R-Ph-T-Ph3-T-Xa-Cy-Z、R-Ph-T-Ph3-T-Xa-Ph
-Z、R-Ph-T-Ph3-T-Xa-Ph1-Z、R-Ph-T-Ph3-T-Xa-Ph3-Z、
R-Ph-T-Ph3-Xa-Cy-Z、R-Ph-T-Ph3-Xa-Ph-Z、R-Ph-T-Ph3
-Xa-Ph1-Z、R-Ph-T-Ph3-Xa-Ph3-Z、R-Ph-Ph3-2-Xa-Cy-
Z、R-Ph-Ph3-2-Xa-Ph-Z、R-Ph-Ph3-2-Xa-Ph1-Z、R-Ph-P
h3-2-Xa-Ph3-Z、R-Ph-Ph3-T-Xa-Cy-Z、R-Ph-Ph3-T-Xa-P
h-Z、R-Ph-Ph3-T-Xa-Ph1-Z、R-Ph-Ph3-T-Xa-Ph3-Z、R-P
h-Ph3-Xa-Cy-Z、R-Ph-Ph3-Xa-Ph-Z、R-Ph-Ph3-Xa-Ph1-
Z、R-Ph-Ph3-Xa-Ph3-Z、R-Ph1-T-Ph-2-Xa-T-Ph-Z、R-Ph
1-T-Ph-2-Xa-T-Ph1-Z、R-Ph1-T-Ph-2-Xa-T-Ph3-Z、R-Ph
1-T-Ph-T-Xa-T-Ph-Z、R-Ph1-T-Ph-T-Xa-T-Ph1-Z、R-Ph1
-T-Ph-T-Xa-T-Ph3-Z、R-Ph1-T-Ph-Xa-T-Ph-Z、R-Ph1-T-
Ph-Xa-T-Ph1-Z、R-Ph1-T-Ph-Xa-T-Ph3-Z、R-Ph1-Ph-2-X
a-T-Ph-Z、R-Ph1-Ph-2-Xa-T-Ph1-Z、R-Ph1-Ph-2-Xa-T-P
h3-Z、R-Ph1-Ph-T-Xa-T-Ph-Z、R-Ph1-Ph-T-Xa-T-Ph1-
Z、R-Ph1-Ph-T-Xa-T-Ph3-Z、R-Ph1-Ph-Xa-T-Ph-Z、R-Ph
1-Ph-Xa-T-Ph1-Z、R-Ph1-Ph-Xa-T-Ph3-Z、R-Ph1-T-Ph-2
-Xa-VO-Ph-Z、R-Ph1-T-Ph-2-Xa-VO-Ph1-Z、R-Ph1-T-Ph-
2-Xa-VO-Ph3-Z、R-Ph1-T-Ph-T-Xa-VO-Ph-Z、R-Ph1-T-Ph
-T-Xa-VO-Ph1-Z、R-Ph1-T-Ph-T-Xa-VO-Ph3-Z、R-Ph1-T-
Ph-Xa-VO-Ph-Z、R-Ph1-T-Ph-Xa-VO-Ph1-Z、R-Ph1-T-Ph-
Xa-VO-Ph3-Z、R-Ph1-Ph-2-Xa-VO-Ph-Z、R-Ph1-Ph-2-Xa-
VO-Ph1-Z、R-Ph1-Ph-2-Xa-VO-Ph3-Z、R-Ph1-Ph-T-Xa-VO
-Ph-Z、R-Ph1-Ph-T-Xa-VO-Ph1-Z、R-Ph1-Ph-T-Xa-VO-Ph
3-Z、R-Ph1-Ph-Xa-VO-Ph-Z、R-Ph1-Ph-Xa-VO-Ph1-Z、R-
Ph1-Ph-Xa-VO-Ph3-Z、R-Ph1-T-Ph-2-Xa-Cy-Z、R-Ph1-T-
Ph-2-Xa-Ph-Z、R-Ph1-T-Ph-2-Xa-Ph1-Z、R-Ph1-T-Ph-2-
Xa-Ph3-Z、R-Ph1-T-Ph-T-Xa-Cy-Z、R-Ph1-T-Ph-T-Xa-Ph
-Z、R-Ph1-T-Ph-T-Xa-Ph1-Z、R-Ph1-T-Ph-T-Xa-Ph3-Z、
R-Ph1-T-Ph-Xa-Cy-Z、R-Ph-Ph3-2-Xa-T-Ph1-Z, R-Ph-Ph3-2-Xa-T
-Ph3-Z, R-Ph-Ph3-T-Xa-T-Ph-Z, R-Ph-Ph3-T-Xa-T-Ph1-
Z, R-Ph-Ph3-T-Xa-T-Ph3-Z, R-Ph-Ph3-Xa-T-Ph-Z, R-Ph
-Ph3-Xa-T-Ph1-Z, R-Ph-Ph3-Xa-T-Ph3-Z, R-Ph-T-Ph3-2
-Xa-VO-Ph-Z, R-Ph-T-Ph3-2-Xa-VO-Ph1-Z, R-Ph-T-Ph3-
2-Xa-VO-Ph3-Z, R-Ph-T-Ph3-T-Xa-VO-Ph-Z, R-Ph-T-Ph3
-T-Xa-VO-Ph1-Z, R-Ph-T-Ph3-T-Xa-VO-Ph3-Z, R-Ph-TP
h3-Xa-VO-Ph-Z, R-Ph-T-Ph3-Xa-VO-Ph1-Z, R-Ph-T-Ph3-
Xa-VO-Ph3-Z, R-Ph-Ph3-2-Xa-VO-Ph-Z, R-Ph-Ph3-2-Xa-
VO-Ph1-Z, R-Ph-Ph3-2-Xa-VO-Ph3-Z, R-Ph-Ph3-T-Xa-VO
-Ph-Z, R-Ph-Ph3-T-Xa-VO-Ph1-Z, R-Ph-Ph3-T-Xa-VO-Ph
3-Z, R-Ph-Ph3-Xa-VO-Ph-Z, R-Ph-Ph3-Xa-VO-Ph1-Z, R-
Ph-Ph3-Xa-VO-Ph3-Z, R-Ph-T-Ph3-2-Xa-Cy-Z, R-Ph-TP
h3-2-Xa-Ph-Z, R-Ph-T-Ph3-2-Xa-Ph1-Z, R-Ph-T-Ph3-2-
Xa-Ph3-Z, R-Ph-T-Ph3-T-Xa-Cy-Z, R-Ph-T-Ph3-T-Xa-Ph
-Z, R-Ph-T-Ph3-T-Xa-Ph1-Z, R-Ph-T-Ph3-T-Xa-Ph3-Z,
R-Ph-T-Ph3-Xa-Cy-Z, R-Ph-T-Ph3-Xa-Ph-Z, R-Ph-T-Ph3
-Xa-Ph1-Z, R-Ph-T-Ph3-Xa-Ph3-Z, R-Ph-Ph3-2-Xa-Cy-
Z, R-Ph-Ph3-2-Xa-Ph-Z, R-Ph-Ph3-2-Xa-Ph1-Z, R-Ph-P
h3-2-Xa-Ph3-Z, R-Ph-Ph3-T-Xa-Cy-Z, R-Ph-Ph3-T-Xa-P
hZ, R-Ph-Ph3-T-Xa-Ph1-Z, R-Ph-Ph3-T-Xa-Ph3-Z, RP
h-Ph3-Xa-Cy-Z, R-Ph-Ph3-Xa-Ph-Z, R-Ph-Ph3-Xa-Ph1-
Z, R-Ph-Ph3-Xa-Ph3-Z, R-Ph1-T-Ph-2-Xa-T-Ph-Z, R-Ph
1-T-Ph-2-Xa-T-Ph1-Z, R-Ph1-T-Ph-2-Xa-T-Ph3-Z, R-Ph
1-T-Ph-T-Xa-T-Ph-Z, R-Ph1-T-Ph-T-Xa-T-Ph1-Z, R-Ph1
-T-Ph-T-Xa-T-Ph3-Z, R-Ph1-T-Ph-Xa-T-Ph-Z, R-Ph1-T-
Ph-Xa-T-Ph1-Z, R-Ph1-T-Ph-Xa-T-Ph3-Z, R-Ph1-Ph-2-X
aT-Ph-Z, R-Ph1-Ph-2-Xa-T-Ph1-Z, R-Ph1-Ph-2-Xa-TP
h3-Z, R-Ph1-Ph-T-Xa-T-Ph-Z, R-Ph1-Ph-T-Xa-T-Ph1-
Z, R-Ph1-Ph-T-Xa-T-Ph3-Z, R-Ph1-Ph-Xa-T-Ph-Z, R-Ph
1-Ph-Xa-T-Ph1-Z, R-Ph1-Ph-Xa-T-Ph3-Z, R-Ph1-T-Ph-2
-Xa-VO-Ph-Z, R-Ph1-T-Ph-2-Xa-VO-Ph1-Z, R-Ph1-T-Ph-
2-Xa-VO-Ph3-Z, R-Ph1-T-Ph-T-Xa-VO-Ph-Z, R-Ph1-T-Ph
-T-Xa-VO-Ph1-Z, R-Ph1-T-Ph-T-Xa-VO-Ph3-Z, R-Ph1-T-
Ph-Xa-VO-Ph-Z, R-Ph1-T-Ph-Xa-VO-Ph1-Z, R-Ph1-T-Ph-
Xa-VO-Ph3-Z, R-Ph1-Ph-2-Xa-VO-Ph-Z, R-Ph1-Ph-2-Xa-
VO-Ph1-Z, R-Ph1-Ph-2-Xa-VO-Ph3-Z, R-Ph1-Ph-T-Xa-VO
-Ph-Z, R-Ph1-Ph-T-Xa-VO-Ph1-Z, R-Ph1-Ph-T-Xa-VO-Ph
3-Z, R-Ph1-Ph-Xa-VO-Ph-Z, R-Ph1-Ph-Xa-VO-Ph1-Z, R-
Ph1-Ph-Xa-VO-Ph3-Z, R-Ph1-T-Ph-2-Xa-Cy-Z, R-Ph1-T-
Ph-2-Xa-Ph-Z, R-Ph1-T-Ph-2-Xa-Ph1-Z, R-Ph1-T-Ph-2-
Xa-Ph3-Z, R-Ph1-T-Ph-T-Xa-Cy-Z, R-Ph1-T-Ph-T-Xa-Ph
-Z, R-Ph1-T-Ph-T-Xa-Ph1-Z, R-Ph1-T-Ph-T-Xa-Ph3-Z,
R-Ph1-T-Ph-Xa-Cy-Z,

【００３５】R-Ph1-T-Ph-Xa-Ph-Z、R-Ph1-T-Ph-Xa-Ph1-
Z、R-Ph1-T-Ph-Xa-Ph3-Z、R-Ph1-Ph-2-Xa-Cy-Z、R-Ph1-
Ph-2-Xa-Ph-Z、R-Ph1-Ph-2-Xa-Ph1-Z、R-Ph1-Ph-2-Xa-P
h3-Z、R-Ph1-Ph-T-Xa-Cy-Z、R-Ph1-Ph-T-Xa-Ph-Z、R-Ph
1-Ph-T-Xa-Ph1-Z、R-Ph1-Ph-T-Xa-Ph3-Z、R-Ph1-Ph-Xa-
Cy-Z、R-Ph1-Ph-Xa-Ph-Z、R-Ph1-Ph-Xa-Ph1-Z、R-Ph1-P
h-Xa-Ph3-Z、R-Ph1-T-Ph1-2-Xa-T-Ph-Z、R-Ph1-T-Ph1-2
-Xa-T-Ph1-Z、R-Ph1-T-Ph1-2-Xa-T-Ph3-Z、R-Ph1-T-Ph1
-T-Xa-T-Ph-Z、R-Ph1-T-Ph1-T-Xa-T-Ph1-Z、R-Ph1-T-Ph
1-T-Xa-T-Ph3-Z、R-Ph1-T-Ph1-Xa-T-Ph-Z、R-Ph1-T-Ph1
-Xa-T-Ph1-Z、R-Ph1-T-Ph1-Xa-T-Ph3-Z、R-Ph1-Ph1-2-X
a-T-Ph-Z、R-Ph1-Ph1-2-Xa-T-Ph1-Z、R-Ph1-Ph1-2-Xa-T
-Ph3-Z、R-Ph1-Ph1-T-Xa-T-Ph-Z、R-Ph1-Ph1-T-Xa-T-Ph
1-Z、R-Ph1-Ph1-T-Xa-T-Ph3-Z、R-Ph1-Ph1-Xa-T-Ph-Z、
R-Ph1-Ph1-Xa-T-Ph1-Z、R-Ph1-Ph1-Xa-T-Ph3-Z、R-Ph1-
T-Ph1-2-Xa-VO-Ph-Z、R-Ph1-T-Ph1-2-Xa-VO-Ph1-Z、R-P
h1-T-Ph1-2-Xa-VO-Ph3-Z、R-Ph1-T-Ph1-T-Xa-VO-Ph-Z、
R-Ph1-T-Ph1-T-Xa-VO-Ph1-Z、R-Ph1-T-Ph1-T-Xa-VO-Ph3
-Z、R-Ph1-T-Ph1-Xa-VO-Ph-Z、R-Ph1-T-Ph1-Xa-VO-Ph1-
Z、R-Ph1-T-Ph1-Xa-VO-Ph3-Z、R-Ph1-Ph1-2-Xa-VO-Ph-
Z、R-Ph1-Ph1-2-Xa-VO-Ph1-Z、R-Ph1-Ph1-2-Xa-VO-Ph3-
Z、R-Ph1-Ph1-T-Xa-VO-Ph-Z、R-Ph1-Ph1-T-Xa-VO-Ph1-
Z、R-Ph1-Ph1-T-Xa-VO-Ph3-Z、R-Ph1-Ph1-Xa-VO-Ph-Z、
R-Ph1-Ph1-Xa-VO-Ph1-Z、R-Ph1-Ph1-Xa-VO-Ph3-Z、R-Ph
1-T-Ph1-2-Xa-Cy-Z、R-Ph1-T-Ph1-2-Xa-Ph-Z、R-Ph1-T-
Ph1-2-Xa-Ph1-Z、R-Ph1-T-Ph1-2-Xa-Ph3-Z、R-Ph1-T-Ph
1-T-Xa-Cy-Z、R-Ph1-T-Ph1-T-Xa-Ph-Z、R-Ph1-T-Ph1-T-
Xa-Ph1-Z、R-Ph1-T-Ph1-T-Xa-Ph3-Z、R-Ph1-T-Ph1-Xa-C
y-Z、R-Ph1-T-Ph1-Xa-Ph-Z、R-Ph1-T-Ph1-Xa-Ph1-Z、R-
Ph1-T-Ph1-Xa-Ph3-Z、R-Ph1-Ph1-2-Xa-Cy-Z、R-Ph1-Ph1
-2-Xa-Ph-Z、R-Ph1-Ph1-2-Xa-Ph1-Z、R-Ph1-Ph1-2-Xa-P
h3-Z、R-Ph1-T-Ph-Xa-Ph-Z, R-Ph1-T-Ph-Xa-Ph1-
Z, R-Ph1-T-Ph-Xa-Ph3-Z, R-Ph1-Ph-2-Xa-Cy-Z, R-Ph1-
Ph-2-Xa-Ph-Z, R-Ph1-Ph-2-Xa-Ph1-Z, R-Ph1-Ph-2-Xa-P
h3-Z, R-Ph1-Ph-T-Xa-Cy-Z, R-Ph1-Ph-T-Xa-Ph-Z, R-Ph
1-Ph-T-Xa-Ph1-Z, R-Ph1-Ph-T-Xa-Ph3-Z, R-Ph1-Ph-Xa-
Cy-Z, R-Ph1-Ph-Xa-Ph-Z, R-Ph1-Ph-Xa-Ph1-Z, R-Ph1-P
h-Xa-Ph3-Z, R-Ph1-T-Ph1-2-Xa-T-Ph-Z, R-Ph1-T-Ph1-2
-Xa-T-Ph1-Z, R-Ph1-T-Ph1-2-Xa-T-Ph3-Z, R-Ph1-T-Ph1
-T-Xa-T-Ph-Z, R-Ph1-T-Ph1-T-Xa-T-Ph1-Z, R-Ph1-T-Ph
1-T-Xa-T-Ph3-Z, R-Ph1-T-Ph1-Xa-T-Ph-Z, R-Ph1-T-Ph1
-Xa-T-Ph1-Z, R-Ph1-T-Ph1-Xa-T-Ph3-Z, R-Ph1-Ph1-2-X
aT-Ph-Z, R-Ph1-Ph1-2-Xa-T-Ph1-Z, R-Ph1-Ph1-2-Xa-T
-Ph3-Z, R-Ph1-Ph1-T-Xa-T-Ph-Z, R-Ph1-Ph1-T-Xa-T-Ph
1-Z, R-Ph1-Ph1-T-Xa-T-Ph3-Z, R-Ph1-Ph1-Xa-T-Ph-Z,
R-Ph1-Ph1-Xa-T-Ph1-Z, R-Ph1-Ph1-Xa-T-Ph3-Z, R-Ph1-
T-Ph1-2-Xa-VO-Ph-Z, R-Ph1-T-Ph1-2-Xa-VO-Ph1-Z, RP
h1-T-Ph1-2-Xa-VO-Ph3-Z, R-Ph1-T-Ph1-T-Xa-VO-Ph-Z,
R-Ph1-T-Ph1-T-Xa-VO-Ph1-Z, R-Ph1-T-Ph1-T-Xa-VO-Ph3
-Z, R-Ph1-T-Ph1-Xa-VO-Ph-Z, R-Ph1-T-Ph1-Xa-VO-Ph1-
Z, R-Ph1-T-Ph1-Xa-VO-Ph3-Z, R-Ph1-Ph1-2-Xa-VO-Ph-
Z, R-Ph1-Ph1-2-Xa-VO-Ph1-Z, R-Ph1-Ph1-2-Xa-VO-Ph3-
Z, R-Ph1-Ph1-T-Xa-VO-Ph-Z, R-Ph1-Ph1-T-Xa-VO-Ph1-
Z, R-Ph1-Ph1-T-Xa-VO-Ph3-Z, R-Ph1-Ph1-Xa-VO-Ph-Z,
R-Ph1-Ph1-Xa-VO-Ph1-Z, R-Ph1-Ph1-Xa-VO-Ph3-Z, R-Ph
1-T-Ph1-2-Xa-Cy-Z, R-Ph1-T-Ph1-2-Xa-Ph-Z, R-Ph1-T-
Ph1-2-Xa-Ph1-Z, R-Ph1-T-Ph1-2-Xa-Ph3-Z, R-Ph1-T-Ph
1-T-Xa-Cy-Z, R-Ph1-T-Ph1-T-Xa-Ph-Z, R-Ph1-T-Ph1-T-
Xa-Ph1-Z, R-Ph1-T-Ph1-T-Xa-Ph3-Z, R-Ph1-T-Ph1-Xa-C
yZ, R-Ph1-T-Ph1-Xa-Ph-Z, R-Ph1-T-Ph1-Xa-Ph1-Z, R-
Ph1-T-Ph1-Xa-Ph3-Z, R-Ph1-Ph1-2-Xa-Cy-Z, R-Ph1-Ph1
-2-Xa-Ph-Z, R-Ph1-Ph1-2-Xa-Ph1-Z, R-Ph1-Ph1-2-Xa-P
h3-Z,

【００３６】R-Ph1-Ph1-T-Xa-Cy-Z、R-Ph1-Ph1-T-Xa-Ph
-Z、R-Ph1-Ph1-T-Xa-Ph1-Z、R-Ph1-Ph1-T-Xa-Ph3-Z、R-
Ph1-Ph1-Xa-Cy-Z、R-Ph1-Ph1-Xa-Ph-Z、R-Ph1-Ph1-Xa-P
h1-Z、R-Ph1-Ph1-Xa-Ph3-Z、R-Ph1-T-Ph3-2-Xa-T-Ph-
Z、R-Ph1-T-Ph3-2-Xa-T-Ph1-Z、R-Ph1-T-Ph3-2-Xa-T-Ph
3-Z、R-Ph1-T-Ph3-T-Xa-T-Ph-Z、R-Ph1-T-Ph3-T-Xa-T-P
h1-Z、R-Ph1-T-Ph3-T-Xa-T-Ph3-Z、R-Ph1-T-Ph3-Xa-T-P
h-Z、R-Ph1-T-Ph3-Xa-T-Ph1-Z、R-Ph1-T-Ph3-Xa-T-Ph3-
Z、R-Ph1-Ph3-2-Xa-T-Ph-Z、R-Ph1-Ph3-2-Xa-T-Ph1-Z、
R-Ph1-Ph3-2-Xa-T-Ph3-Z、R-Ph1-Ph3-T-Xa-T-Ph-Z、R-P
h1-Ph3-T-Xa-T-Ph1-Z、R-Ph1-Ph3-T-Xa-T-Ph3-Z、R-Ph1
-Ph3-Xa-T-Ph-Z、R-Ph1-Ph3-Xa-T-Ph1-Z、R-Ph1-Ph3-Xa
-T-Ph3-Z、R-Ph1-T-Ph3-2-Xa-VO-Ph-Z、R-Ph1-T-Ph3-2-
Xa-VO-Ph1-Z、R-Ph1-T-Ph3-2-Xa-VO-Ph3-Z、R-Ph1-T-Ph
3-T-Xa-VO-Ph-Z、R-Ph1-T-Ph3-T-Xa-VO-Ph1-Z、R-Ph1-T
-Ph3-T-Xa-VO-Ph3-Z、R-Ph1-T-Ph3-Xa-VO-Ph-Z、R-Ph1-
T-Ph3-Xa-VO-Ph1-Z、R-Ph1-T-Ph3-Xa-VO-Ph3-Z、R-Ph1-
Ph3-2-Xa-VO-Ph-Z、R-Ph1-Ph3-2-Xa-VO-Ph1-Z、R-Ph1-P
h3-2-Xa-VO-Ph3-Z、R-Ph1-Ph3-T-Xa-VO-Ph-Z、R-Ph1-Ph
3-T-Xa-VO-Ph1-Z、R-Ph1-Ph3-T-Xa-VO-Ph3-Z、R-Ph1-Ph
3-Xa-VO-Ph-Z、R-Ph1-Ph3-Xa-VO-Ph1-Z、R-Ph1-Ph3-Xa-
VO-Ph3-Z、R-Ph1-T-Ph3-2-Xa-Cy-Z、R-Ph1-T-Ph3-2-Xa-
Ph-Z、R-Ph1-T-Ph3-2-Xa-Ph1-Z、R-Ph1-T-Ph3-2-Xa-Ph3
-Z、R-Ph1-T-Ph3-T-Xa-Cy-Z、R-Ph1-T-Ph3-T-Xa-Ph-Z、
R-Ph1-T-Ph3-T-Xa-Ph1-Z、R-Ph1-T-Ph3-T-Xa-Ph3-Z、R-
Ph1-T-Ph3-Xa-Cy-Z、R-Ph1-T-Ph3-Xa-Ph-Z、R-Ph1-T-Ph
3-Xa-Ph1-Z、R-Ph1-T-Ph3-Xa-Ph3-Z、R-Ph1-Ph3-2-Xa-C
y-Z、R-Ph1-Ph3-2-Xa-Ph-Z、R-Ph1-Ph3-2-Xa-Ph1-Z、R-
Ph1-Ph3-2-Xa-Ph3-Z、R-Ph1-Ph3-T-Xa-Cy-Z、R-Ph1-Ph3
-T-Xa-Ph-Z、R-Ph1-Ph3-T-Xa-Ph1-Z、R-Ph1-Ph3-T-Xa-P
h3-Z、R-Ph1-Ph3-Xa-Cy-Z、R-Ph1-Ph3-Xa-Ph-Z、R-Ph1-
Ph3-Xa-Ph1-Z、R-Ph1-Ph3-Xa-Ph3-Z、R-Ph3-T-Ph-2-Xa-
T-Ph-Z、R-Ph3-T-Ph-2-Xa-T-Ph1-Z、R-Ph3-T-Ph-2-Xa-T
-Ph3-Z、R-Ph3-T-Ph-T-Xa-T-Ph-Z、R-Ph3-T-Ph-T-Xa-T-
Ph1-Z、R-Ph3-T-Ph-T-Xa-T-Ph3-Z、R-Ph3-T-Ph-Xa-T-Ph
-Z、R-Ph3-T-Ph-Xa-T-Ph1-Z、R-Ph3-T-Ph-Xa-T-Ph3-Z、
R-Ph3-Ph-2-Xa-T-Ph-Z、R-Ph3-Ph-2-Xa-T-Ph1-Z、R-Ph3
-Ph-2-Xa-T-Ph3-Z、R-Ph3-Ph-T-Xa-T-Ph-Z、R-Ph3-Ph-T
-Xa-T-Ph1-Z、R-Ph3-Ph-T-Xa-T-Ph3-Z、R-Ph3-Ph-Xa-T-
Ph-Z、R-Ph3-Ph-Xa-T-Ph1-Z、R-Ph3-Ph-Xa-T-Ph3-Z、R-
Ph3-T-Ph-2-Xa-VO-Ph-Z、R-Ph3-T-Ph-2-Xa-VO-Ph1-Z、R
-Ph3-T-Ph-2-Xa-VO-Ph3-Z、R-Ph3-T-Ph-T-Xa-VO-Ph-Z、
R-Ph3-T-Ph-T-Xa-VO-Ph1-Z、R-Ph1-Ph1-T-Xa-Cy-Z, R-Ph1-Ph1-T-Xa-Ph
-Z, R-Ph1-Ph1-T-Xa-Ph1-Z, R-Ph1-Ph1-T-Xa-Ph3-Z, R-
Ph1-Ph1-Xa-Cy-Z, R-Ph1-Ph1-Xa-Ph-Z, R-Ph1-Ph1-Xa-P
h1-Z, R-Ph1-Ph1-Xa-Ph3-Z, R-Ph1-T-Ph3-2-Xa-T-Ph-
Z, R-Ph1-T-Ph3-2-Xa-T-Ph1-Z, R-Ph1-T-Ph3-2-Xa-T-Ph
3-Z, R-Ph1-T-Ph3-T-Xa-T-Ph-Z, R-Ph1-T-Ph3-T-Xa-TP
h1-Z, R-Ph1-T-Ph3-T-Xa-T-Ph3-Z, R-Ph1-T-Ph3-Xa-TP
hZ, R-Ph1-T-Ph3-Xa-T-Ph1-Z, R-Ph1-T-Ph3-Xa-T-Ph3-
Z, R-Ph1-Ph3-2-Xa-T-Ph-Z, R-Ph1-Ph3-2-Xa-T-Ph1-Z,
R-Ph1-Ph3-2-Xa-T-Ph3-Z, R-Ph1-Ph3-T-Xa-T-Ph-Z, RP
h1-Ph3-T-Xa-T-Ph1-Z, R-Ph1-Ph3-T-Xa-T-Ph3-Z, R-Ph1
-Ph3-Xa-T-Ph-Z, R-Ph1-Ph3-Xa-T-Ph1-Z, R-Ph1-Ph3-Xa
-T-Ph3-Z, R-Ph1-T-Ph3-2-Xa-VO-Ph-Z, R-Ph1-T-Ph3-2-
Xa-VO-Ph1-Z, R-Ph1-T-Ph3-2-Xa-VO-Ph3-Z, R-Ph1-T-Ph
3-T-Xa-VO-Ph-Z, R-Ph1-T-Ph3-T-Xa-VO-Ph1-Z, R-Ph1-T
-Ph3-T-Xa-VO-Ph3-Z, R-Ph1-T-Ph3-Xa-VO-Ph-Z, R-Ph1-
T-Ph3-Xa-VO-Ph1-Z, R-Ph1-T-Ph3-Xa-VO-Ph3-Z, R-Ph1-
Ph3-2-Xa-VO-Ph-Z, R-Ph1-Ph3-2-Xa-VO-Ph1-Z, R-Ph1-P
h3-2-Xa-VO-Ph3-Z, R-Ph1-Ph3-T-Xa-VO-Ph-Z, R-Ph1-Ph
3-T-Xa-VO-Ph1-Z, R-Ph1-Ph3-T-Xa-VO-Ph3-Z, R-Ph1-Ph
3-Xa-VO-Ph-Z, R-Ph1-Ph3-Xa-VO-Ph1-Z, R-Ph1-Ph3-Xa-
VO-Ph3-Z, R-Ph1-T-Ph3-2-Xa-Cy-Z, R-Ph1-T-Ph3-2-Xa-
Ph-Z, R-Ph1-T-Ph3-2-Xa-Ph1-Z, R-Ph1-T-Ph3-2-Xa-Ph3
-Z, R-Ph1-T-Ph3-T-Xa-Cy-Z, R-Ph1-T-Ph3-T-Xa-Ph-Z,
R-Ph1-T-Ph3-T-Xa-Ph1-Z, R-Ph1-T-Ph3-T-Xa-Ph3-Z, R-
Ph1-T-Ph3-Xa-Cy-Z, R-Ph1-T-Ph3-Xa-Ph-Z, R-Ph1-T-Ph
3-Xa-Ph1-Z, R-Ph1-T-Ph3-Xa-Ph3-Z, R-Ph1-Ph3-2-Xa-C
yZ, R-Ph1-Ph3-2-Xa-Ph-Z, R-Ph1-Ph3-2-Xa-Ph1-Z, R-
Ph1-Ph3-2-Xa-Ph3-Z, R-Ph1-Ph3-T-Xa-Cy-Z, R-Ph1-Ph3
-T-Xa-Ph-Z, R-Ph1-Ph3-T-Xa-Ph1-Z, R-Ph1-Ph3-T-Xa-P
h3-Z, R-Ph1-Ph3-Xa-Cy-Z, R-Ph1-Ph3-Xa-Ph-Z, R-Ph1-
Ph3-Xa-Ph1-Z, R-Ph1-Ph3-Xa-Ph3-Z, R-Ph3-T-Ph-2-Xa-
T-Ph-Z, R-Ph3-T-Ph-2-Xa-T-Ph1-Z, R-Ph3-T-Ph-2-Xa-T
-Ph3-Z, R-Ph3-T-Ph-T-Xa-T-Ph-Z, R-Ph3-T-Ph-T-Xa-T-
Ph1-Z, R-Ph3-T-Ph-T-Xa-T-Ph3-Z, R-Ph3-T-Ph-Xa-T-Ph
-Z, R-Ph3-T-Ph-Xa-T-Ph1-Z, R-Ph3-T-Ph-Xa-T-Ph3-Z,
R-Ph3-Ph-2-Xa-T-Ph-Z, R-Ph3-Ph-2-Xa-T-Ph1-Z, R-Ph3
-Ph-2-Xa-T-Ph3-Z, R-Ph3-Ph-T-Xa-T-Ph-Z, R-Ph3-Ph-T
-Xa-T-Ph1-Z, R-Ph3-Ph-T-Xa-T-Ph3-Z, R-Ph3-Ph-Xa-T-
Ph-Z, R-Ph3-Ph-Xa-T-Ph1-Z, R-Ph3-Ph-Xa-T-Ph3-Z, R-
Ph3-T-Ph-2-Xa-VO-Ph-Z, R-Ph3-T-Ph-2-Xa-VO-Ph1-Z, R
-Ph3-T-Ph-2-Xa-VO-Ph3-Z, R-Ph3-T-Ph-T-Xa-VO-Ph-Z,
R-Ph3-T-Ph-T-Xa-VO-Ph1-Z,

【００３７】R-Ph3-T-Ph-T-Xa-VO-Ph3-Z、R-Ph3-T-Ph-X
a-VO-Ph-Z、R-Ph3-T-Ph-Xa-VO-Ph1-Z、R-Ph3-T-Ph-Xa-V
O-Ph3-Z、R-Ph3-Ph-2-Xa-VO-Ph-Z、R-Ph3-Ph-2-Xa-VO-P
h1-Z、R-Ph3-Ph-2-Xa-VO-Ph3-Z、R-Ph3-Ph-T-Xa-VO-Ph-
Z、R-Ph3-Ph-T-Xa-VO-Ph1-Z、R-Ph3-Ph-T-Xa-VO-Ph3-
Z、R-Ph3-Ph-Xa-VO-Ph-Z、R-Ph3-Ph-Xa-VO-Ph1-Z、R-Ph
3-Ph-Xa-VO-Ph3-Z、R-Ph3-T-Ph-2-Xa-Cy-Z、R-Ph3-T-Ph
-2-Xa-Ph-Z、R-Ph3-T-Ph-2-Xa-Ph1-Z、R-Ph3-T-Ph-2-Xa
-Ph3-Z、R-Ph3-T-Ph-T-Xa-Cy-Z、R-Ph3-T-Ph-T-Xa-Ph-
Z、R-Ph3-T-Ph-T-Xa-Ph1-Z、R-Ph3-T-Ph-T-Xa-Ph3-Z、R
-Ph3-T-Ph-Xa-Cy-Z、R-Ph3-T-Ph-Xa-Ph-Z、R-Ph3-T-Ph-
Xa-Ph1-Z、R-Ph3-T-Ph-Xa-Ph3-Z、R-Ph3-Ph-2-Xa-Cy-
Z、R-Ph3-Ph-2-Xa-Ph-Z、R-Ph3-Ph-2-Xa-Ph1-Z、R-Ph3-
Ph-2-Xa-Ph3-Z、R-Ph3-Ph-T-Xa-Cy-Z、R-Ph3-Ph-T-Xa-P
h-Z、R-Ph3-Ph-T-Xa-Ph1-Z、R-Ph3-Ph-T-Xa-Ph3-Z、R-P
h3-Ph-Xa-Cy-Z、R-Ph3-Ph-Xa-Ph-Z、R-Ph3-Ph-Xa-Ph1-
Z、R-Ph3-Ph-Xa-Ph3-Z、R-Ph3-T-Ph1-2-Xa-T-Ph-Z、R-P
h3-T-Ph1-2-Xa-T-Ph1-Z、R-Ph3-T-Ph1-2-Xa-T-Ph3-Z、R
-Ph3-T-Ph1-T-Xa-T-Ph-Z、R-Ph3-T-Ph1-T-Xa-T-Ph1-Z、
R-Ph3-T-Ph1-T-Xa-T-Ph3-Z、R-Ph3-T-Ph1-Xa-T-Ph-Z、R
-Ph3-T-Ph1-Xa-T-Ph1-Z、R-Ph3-T-Ph1-Xa-T-Ph3-Z、R-P
h3-Ph1-2-Xa-T-Ph-Z、R-Ph3-Ph1-2-Xa-T-Ph1-Z、R-Ph3-
Ph1-2-Xa-T-Ph3-Z、R-Ph3-Ph1-T-Xa-T-Ph-Z、R-Ph3-Ph1
-T-Xa-T-Ph1-Z、R-Ph3-Ph1-T-Xa-T-Ph3-Z、R-Ph3-Ph1-X
a-T-Ph-Z、R-Ph3-Ph1-Xa-T-Ph1-Z、R-Ph3-Ph1-Xa-T-Ph3
-Z、R-Ph3-T-Ph1-2-Xa-VO-Ph-Z、R-Ph3-T-Ph1-2-Xa-VO-
Ph1-Z、R-Ph3-T-Ph1-2-Xa-VO-Ph3-Z、R-Ph3-T-Ph1-T-Xa
-VO-Ph-Z、R-Ph3-T-Ph1-T-Xa-VO-Ph1-Z、R-Ph3-T-Ph1-T
-Xa-VO-Ph3-Z、R-Ph3-T-Ph1-Xa-VO-Ph-Z、R-Ph3-T-Ph1-
Xa-VO-Ph1-Z、R-Ph3-T-Ph1-Xa-VO-Ph3-Z、R-Ph3-Ph1-2-
Xa-VO-Ph-Z、R-Ph3-Ph1-2-Xa-VO-Ph1-Z、R-Ph3-Ph1-2-X
a-VO-Ph3-Z、R-Ph3-Ph1-T-Xa-VO-Ph-Z、R-Ph3-Ph-Z、R-Ph3-T-Ph-T-Xa-VO-Ph3-Z, R-Ph3-T-Ph-X
a-VO-Ph-Z, R-Ph3-T-Ph-Xa-VO-Ph1-Z, R-Ph3-T-Ph-Xa-V
O-Ph3-Z, R-Ph3-Ph-2-Xa-VO-Ph-Z, R-Ph3-Ph-2-Xa-VO-P
h1-Z, R-Ph3-Ph-2-Xa-VO-Ph3-Z, R-Ph3-Ph-T-Xa-VO-Ph-
Z, R-Ph3-Ph-T-Xa-VO-Ph1-Z, R-Ph3-Ph-T-Xa-VO-Ph3-
Z, R-Ph3-Ph-Xa-VO-Ph-Z, R-Ph3-Ph-Xa-VO-Ph1-Z, R-Ph
3-Ph-Xa-VO-Ph3-Z, R-Ph3-T-Ph-2-Xa-Cy-Z, R-Ph3-T-Ph
-2-Xa-Ph-Z, R-Ph3-T-Ph-2-Xa-Ph1-Z, R-Ph3-T-Ph-2-Xa
-Ph3-Z, R-Ph3-T-Ph-T-Xa-Cy-Z, R-Ph3-T-Ph-T-Xa-Ph-
Z, R-Ph3-T-Ph-T-Xa-Ph1-Z, R-Ph3-T-Ph-T-Xa-Ph3-Z, R
-Ph3-T-Ph-Xa-Cy-Z, R-Ph3-T-Ph-Xa-Ph-Z, R-Ph3-T-Ph-
Xa-Ph1-Z, R-Ph3-T-Ph-Xa-Ph3-Z, R-Ph3-Ph-2-Xa-Cy-
Z, R-Ph3-Ph-2-Xa-Ph-Z, R-Ph3-Ph-2-Xa-Ph1-Z, R-Ph3-
Ph-2-Xa-Ph3-Z, R-Ph3-Ph-T-Xa-Cy-Z, R-Ph3-Ph-T-Xa-P
hZ, R-Ph3-Ph-T-Xa-Ph1-Z, R-Ph3-Ph-T-Xa-Ph3-Z, RP
h3-Ph-Xa-Cy-Z, R-Ph3-Ph-Xa-Ph-Z, R-Ph3-Ph-Xa-Ph1-
Z, R-Ph3-Ph-Xa-Ph3-Z, R-Ph3-T-Ph1-2-Xa-T-Ph-Z, RP
h3-T-Ph1-2-Xa-T-Ph1-Z, R-Ph3-T-Ph1-2-Xa-T-Ph3-Z, R
-Ph3-T-Ph1-T-Xa-T-Ph-Z, R-Ph3-T-Ph1-T-Xa-T-Ph1-Z,
R-Ph3-T-Ph1-T-Xa-T-Ph3-Z, R-Ph3-T-Ph1-Xa-T-Ph-Z, R
-Ph3-T-Ph1-Xa-T-Ph1-Z, R-Ph3-T-Ph1-Xa-T-Ph3-Z, RP
h3-Ph1-2-Xa-T-Ph-Z, R-Ph3-Ph1-2-Xa-T-Ph1-Z, R-Ph3-
Ph1-2-Xa-T-Ph3-Z, R-Ph3-Ph1-T-Xa-T-Ph-Z, R-Ph3-Ph1
-T-Xa-T-Ph1-Z, R-Ph3-Ph1-T-Xa-T-Ph3-Z, R-Ph3-Ph1-X
aT-Ph-Z, R-Ph3-Ph1-Xa-T-Ph1-Z, R-Ph3-Ph1-Xa-T-Ph3
-Z, R-Ph3-T-Ph1-2-Xa-VO-Ph-Z, R-Ph3-T-Ph1-2-Xa-VO-
Ph1-Z, R-Ph3-T-Ph1-2-Xa-VO-Ph3-Z, R-Ph3-T-Ph1-T-Xa
-VO-Ph-Z, R-Ph3-T-Ph1-T-Xa-VO-Ph1-Z, R-Ph3-T-Ph1-T
-Xa-VO-Ph3-Z, R-Ph3-T-Ph1-Xa-VO-Ph-Z, R-Ph3-T-Ph1-
Xa-VO-Ph1-Z, R-Ph3-T-Ph1-Xa-VO-Ph3-Z, R-Ph3-Ph1-2-
Xa-VO-Ph-Z, R-Ph3-Ph1-2-Xa-VO-Ph1-Z, R-Ph3-Ph1-2-X
a-VO-Ph3-Z, R-Ph3-Ph1-T-Xa-VO-Ph-Z, R-Ph3-Ph-Z,

【００３８】1-T-Xa-VO-Ph1-Z、R-Ph3-Ph1-T-Xa-VO-Ph3
-Z、R-Ph3-Ph1-Xa-VO-Ph-Z、R-Ph3-Ph1-Xa-VO-Ph1-Z、R
-Ph3-Ph1-Xa-VO-Ph3-Z、R-Ph3-T-Ph1-2-Xa-Cy-Z、R-Ph3
-T-Ph1-2-Xa-Ph-Z、R-Ph3-T-Ph1-2-Xa-Ph1-Z、R-Ph3-T-
Ph1-2-Xa-Ph3-Z、R-Ph3-T-Ph1-T-Xa-Cy-Z、R-Ph3-T-Ph1
-T-Xa-Ph-Z、R-Ph3-T-Ph1-T-Xa-Ph1-Z、R-Ph3-T-Ph1-T-
Xa-Ph3-Z、R-Ph3-T-Ph1-Xa-Cy-Z、R-Ph3-T-Ph1-Xa-Ph-
Z、R-Ph3-T-Ph1-Xa-Ph1-Z、R-Ph3-T-Ph1-Xa-Ph3-Z、R-P
h3-Ph1-2-Xa-Cy-Z、R-Ph3-Ph1-2-Xa-Ph-Z、R-Ph3-Ph1-2
-Xa-Ph1-Z、R-Ph3-Ph1-2-Xa-Ph3-Z、R-Ph3-Ph1-T-Xa-Cy
-Z、R-Ph3-Ph1-T-Xa-Ph-Z、R-Ph3-Ph1-T-Xa-Ph1-Z、R-P
h3-Ph1-T-Xa-Ph3-Z、R-Ph3-Ph1-Xa-Cy-Z、R-Ph3-Ph1-Xa
-Ph-Z、R-Ph3-Ph1-Xa-Ph1-Z、R-Ph3-Ph1-Xa-Ph3-Z、R-P
h3-T-Ph3-2-Xa-T-Ph-Z、R-Ph3-T-Ph3-2-Xa-T-Ph1-Z、R-
Ph3-T-Ph3-2-Xa-T-Ph3-Z、R-Ph3-T-Ph3-T-Xa-T-Ph-Z、R
-Ph3-T-Ph3-T-Xa-T-Ph1-Z、R-Ph3-T-Ph3-T-Xa-T-Ph3-
Z、R-Ph3-T-Ph3-Xa-T-Ph-Z、R-Ph3-T-Ph3-Xa-T-Ph1-Z、
R-Ph3-T-Ph3-Xa-T-Ph3-Z、R-Ph3-Ph3-2-Xa-T-Ph-Z、R-P
h3-Ph3-2-Xa-T-Ph1-Z、R-Ph3-Ph3-2-Xa-T-Ph3-Z、R-Ph3
-Ph3-T-Xa-T-Ph-Z、R-Ph3-Ph3-T-Xa-T-Ph1-Z、R-Ph3-Ph
3-T-Xa-T-Ph3-Z、R-Ph3-Ph3-Xa-T-Ph-Z、R-Ph3-Ph3-Xa-
T-Ph1-Z、R-Ph3-Ph3-Xa-T-Ph3-Z、R-Ph3-T-Ph3-2-Xa-VO
-Ph-Z、R-Ph3-T-Ph3-2-Xa-VO-Ph1-Z、R-Ph3-T-Ph3-2-Xa
-VO-Ph3-Z、R-Ph3-T-Ph3-T-Xa-VO-Ph-Z、R-Ph3-T-Ph3-T
-Xa-VO-Ph1-Z、R-Ph3-T-Ph3-T-Xa-VO-Ph3-Z、R-Ph3-T-P
h3-Xa-VO-Ph-Z、R-Ph3-T-Ph3-Xa-VO-Ph1-Z、R-Ph3-T-Ph
3-Xa-VO-Ph3-Z、R-Ph3-Ph3-2-Xa-VO-Ph-Z、R-Ph3-Ph3-2
-Xa-VO-Ph1-Z、R-Ph3-Ph3-2-Xa-VO-Ph3-Z、R-Ph3-Ph3-T
-Xa-VO-Ph-Z、R-Ph3-Ph3-T-Xa-VO-Ph1-Z、R-Ph3-Ph3-T-
Xa-VO-Ph3-Z、R-Ph3-Ph3-Xa-VO-Ph-Z、R-Ph3-Ph3-Xa-VO
-Ph1-Z、R-Ph3-Ph3-Xa-VO-Ph3-Z、R-Ph3-T-Ph3-2-Xa-Cy
-Z、R-Ph3-T-Ph3-2-Xa-Ph-Z、R-Ph3-T-Ph3-2-Xa-Ph1-
Z、R-Ph3-T-Ph3-2-Xa-Ph3-Z、R-Ph3-T-Ph3-T-Xa-Cy-Z、
R-Ph3-T-Ph3-T-Xa-Ph-Z、R-Ph3-T-Ph3-T-Xa-Ph1-Z、R-P
h3-T-Ph3-T-Xa-Ph3-Z、R-Ph3-T-Ph3-Xa-Cy-Z、R-Ph3-T-
Ph3-Xa-Ph-Z、R-Ph3-T-Ph3-Xa-Ph1-Z、R-Ph3-T-Ph3-Xa-
Ph3-Z、R-Ph3-Ph3-2-Xa-Cy-Z、R-Ph3-Ph3-2-Xa-Ph-Z、R
-Ph3-Ph3-2-Xa-Ph1-Z、R-Ph3-Ph3-2-Xa-Ph3-Z、R-Ph3-P
h3-T-Xa-Cy-Z、R-Ph3-Ph3-T-Xa-Ph-Z、R-Ph3-Ph3-T-Xa-
Ph1-Z、R-Ph3-Ph3-T-Xa-Ph3-Z、R-Ph3-Ph3-Xa-Cy-Z、R-
Ph3-Ph3-Xa-Ph-Z、R-Ph3-Ph3-Xa-Ph1-Z、R-Ph3-Ph3-Xa-
Ph3-Z1-T-Xa-VO-Ph1-Z, R-Ph3-Ph1-T-Xa-VO-Ph3
-Z, R-Ph3-Ph1-Xa-VO-Ph-Z, R-Ph3-Ph1-Xa-VO-Ph1-Z, R
-Ph3-Ph1-Xa-VO-Ph3-Z, R-Ph3-T-Ph1-2-Xa-Cy-Z, R-Ph3
-T-Ph1-2-Xa-Ph-Z, R-Ph3-T-Ph1-2-Xa-Ph1-Z, R-Ph3-T-
Ph1-2-Xa-Ph3-Z, R-Ph3-T-Ph1-T-Xa-Cy-Z, R-Ph3-T-Ph1
-T-Xa-Ph-Z, R-Ph3-T-Ph1-T-Xa-Ph1-Z, R-Ph3-T-Ph1-T-
Xa-Ph3-Z, R-Ph3-T-Ph1-Xa-Cy-Z, R-Ph3-T-Ph1-Xa-Ph-
Z, R-Ph3-T-Ph1-Xa-Ph1-Z, R-Ph3-T-Ph1-Xa-Ph3-Z, RP
h3-Ph1-2-Xa-Cy-Z, R-Ph3-Ph1-2-Xa-Ph-Z, R-Ph3-Ph1-2
-Xa-Ph1-Z, R-Ph3-Ph1-2-Xa-Ph3-Z, R-Ph3-Ph1-T-Xa-Cy
-Z, R-Ph3-Ph1-T-Xa-Ph-Z, R-Ph3-Ph1-T-Xa-Ph1-Z, RP
h3-Ph1-T-Xa-Ph3-Z, R-Ph3-Ph1-Xa-Cy-Z, R-Ph3-Ph1-Xa
-Ph-Z, R-Ph3-Ph1-Xa-Ph1-Z, R-Ph3-Ph1-Xa-Ph3-Z, RP
h3-T-Ph3-2-Xa-T-Ph-Z, R-Ph3-T-Ph3-2-Xa-T-Ph1-Z, R-
Ph3-T-Ph3-2-Xa-T-Ph3-Z, R-Ph3-T-Ph3-T-Xa-T-Ph-Z, R
-Ph3-T-Ph3-T-Xa-T-Ph1-Z, R-Ph3-T-Ph3-T-Xa-T-Ph3-
Z, R-Ph3-T-Ph3-Xa-T-Ph-Z, R-Ph3-T-Ph3-Xa-T-Ph1-Z,
R-Ph3-T-Ph3-Xa-T-Ph3-Z, R-Ph3-Ph3-2-Xa-T-Ph-Z, RP
h3-Ph3-2-Xa-T-Ph1-Z, R-Ph3-Ph3-2-Xa-T-Ph3-Z, R-Ph3
-Ph3-T-Xa-T-Ph-Z, R-Ph3-Ph3-T-Xa-T-Ph1-Z, R-Ph3-Ph
3-T-Xa-T-Ph3-Z, R-Ph3-Ph3-Xa-T-Ph-Z, R-Ph3-Ph3-Xa-
T-Ph1-Z, R-Ph3-Ph3-Xa-T-Ph3-Z, R-Ph3-T-Ph3-2-Xa-VO
-Ph-Z, R-Ph3-T-Ph3-2-Xa-VO-Ph1-Z, R-Ph3-T-Ph3-2-Xa
-VO-Ph3-Z, R-Ph3-T-Ph3-T-Xa-VO-Ph-Z, R-Ph3-T-Ph3-T
-Xa-VO-Ph1-Z, R-Ph3-T-Ph3-T-Xa-VO-Ph3-Z, R-Ph3-TP
h3-Xa-VO-Ph-Z, R-Ph3-T-Ph3-Xa-VO-Ph1-Z, R-Ph3-T-Ph
3-Xa-VO-Ph3-Z, R-Ph3-Ph3-2-Xa-VO-Ph-Z, R-Ph3-Ph3-2
-Xa-VO-Ph1-Z, R-Ph3-Ph3-2-Xa-VO-Ph3-Z, R-Ph3-Ph3-T
-Xa-VO-Ph-Z, R-Ph3-Ph3-T-Xa-VO-Ph1-Z, R-Ph3-Ph3-T-
Xa-VO-Ph3-Z, R-Ph3-Ph3-Xa-VO-Ph-Z, R-Ph3-Ph3-Xa-VO
-Ph1-Z, R-Ph3-Ph3-Xa-VO-Ph3-Z, R-Ph3-T-Ph3-2-Xa-Cy
-Z, R-Ph3-T-Ph3-2-Xa-Ph-Z, R-Ph3-T-Ph3-2-Xa-Ph1-
Z, R-Ph3-T-Ph3-2-Xa-Ph3-Z, R-Ph3-T-Ph3-T-Xa-Cy-Z,
R-Ph3-T-Ph3-T-Xa-Ph-Z, R-Ph3-T-Ph3-T-Xa-Ph1-Z, RP
h3-T-Ph3-T-Xa-Ph3-Z, R-Ph3-T-Ph3-Xa-Cy-Z, R-Ph3-T-
Ph3-Xa-Ph-Z, R-Ph3-T-Ph3-Xa-Ph1-Z, R-Ph3-T-Ph3-Xa-
Ph3-Z, R-Ph3-Ph3-2-Xa-Cy-Z, R-Ph3-Ph3-2-Xa-Ph-Z, R
-Ph3-Ph3-2-Xa-Ph1-Z, R-Ph3-Ph3-2-Xa-Ph3-Z, R-Ph3-P
h3-T-Xa-Cy-Z, R-Ph3-Ph3-T-Xa-Ph-Z, R-Ph3-Ph3-T-Xa-
Ph1-Z, R-Ph3-Ph3-T-Xa-Ph3-Z, R-Ph3-Ph3-Xa-Cy-Z, R-
Ph3-Ph3-Xa-Ph-Z, R-Ph3-Ph3-Xa-Ph1-Z, R-Ph3-Ph3-Xa-
Ph3-Z

【００３９】R-Xa-2-Ph-G-Ph-Z、R-Xa-2-Ph-G-Ph1-Z、R
-Xa-2-Ph-G-Ph3-Z、R-Xa-2-Ph-T-Ph-Z、R-Xa-2-Ph-T-Ph
1-Z、R-Xa-2-Ph-T-Ph3-Z、R-Xa-2-Ph-VO-Ph-Z、R-Xa-2-
Ph-VO-Ph1-Z、R-Xa-2-Ph-VO-Ph3-Z、R-Xa-2-Ph-Cy-Z、R
-Xa-2-Ph-Ph-Z、R-Xa-2-Ph-Ph1-Z、R-Xa-2-Ph-Ph3-Z、R
-Xa-2-Ph1-G-Ph-Z、R-Xa-2-Ph1-G-Ph1-Z、R-Xa-2-Ph1-G
-Ph3-Z、R-Xa-2-Ph1-T-Ph-Z、R-Xa-2-Ph1-T-Ph1-Z、R-X
a-2-Ph1-T-Ph3-Z、R-Xa-2-Ph1-VO-Ph-Z、R-Xa-2-Ph1-VO
-Ph1-Z、R-Xa-2-Ph1-VO-Ph3-Z、R-Xa-2-Ph1-Cy-Z、R-Xa
-2-Ph1-Ph-Z、R-Xa-2-Ph1-Ph1-Z、R-Xa-2-Ph1-Ph3-Z、R
-Xa-2-Ph3-G-Ph-Z、R-Xa-2-Ph3-G-Ph1-Z、R-Xa-2-Ph3-G
-Ph3-Z、R-Xa-2-Ph3-T-Ph-Z、R-Xa-2-Ph3-T-Ph1-Z、R-X
a-2-Ph3-T-Ph3-Z、R-Xa-2-Ph3-VO-Ph-Z、R-Xa-2-Ph3-VO
-Ph1-Z、R-Xa-2-Ph3-VO-Ph3-Z、R-Xa-2-Ph3-Cy-Z、R-Xa
-2-Ph3-Ph-Z、R-Xa-2-Ph3-Ph1-Z、R-Xa-2-Ph3-Ph3-Z、R
-Xa-G-Ph-G-Ph-Z、R-Xa-G-Ph-G-Ph1-Z、R-Xa-G-Ph-G-Ph
3-Z、R-Xa-G-Ph-T-Ph-Z、R-Xa-G-Ph-T-Ph1-Z、R-Xa-G-P
h-T-Ph3-Z、R-Xa-G-Ph-VO-Ph-Z、R-Xa-G-Ph-VO-Ph1-Z、
R-Xa-G-Ph-VO-Ph3-Z、R-Xa-G-Ph-Cy-Z、R-Xa-G-Ph-Ph-
Z、R-Xa-G-Ph-Ph1-Z、R-Xa-G-Ph-Ph3-Z、R-Xa-G-Ph1-G-
Ph-Z、R-Xa-G-Ph1-G-Ph1-Z、R-Xa-G-Ph1-G-Ph3-Z、R-Xa
-G-Ph1-T-Ph-Z、R-Xa-G-Ph1-T-Ph1-Z、R-Xa-G-Ph1-T-Ph
3-Z、R-Xa-G-Ph1-VO-Ph-Z、R-Xa-G-Ph1-VO-Ph1-Z、R-Xa
-G-Ph1-VO-Ph3-Z、R-Xa-G-Ph1-Cy-Z、R-Xa-G-Ph1-Ph-
Z、R-Xa-G-Ph1-Ph1-Z、R-Xa-G-Ph1-Ph3-Z、R-Xa-G-Ph3-
G-Ph-Z、R-Xa-G-Ph3-G-Ph1-Z、R-Xa-G-Ph3-G-Ph3-Z、R-
Xa-G-Ph3-T-Ph-Z、R-Xa-G-Ph3-T-Ph1-Z、R-Xa-G-Ph3-T-
Ph3-Z、R-Xa-G-Ph3-VO-Ph-Z、R-Xa-G-Ph3-VO-Ph1-Z、R-
Xa-G-Ph3-VO-Ph3-Z、R-Xa-G-Ph3-Cy-Z、R-Xa-G-Ph3-Ph-
Z、R-Xa-G-Ph3-Ph1-Z、R-Xa-G-Ph3-Ph3-Z、R-Xa-T-Ph-G
-Ph-Z、R-Xa-T-Ph-G-Ph1-Z、R-Xa-T-Ph-G-Ph3-Z、R-Xa-
T-Ph-T-Ph-Z、R-Xa-T-Ph-T-Ph1-Z、R-Xa-T-Ph-T-Ph3-
Z、R-Xa-T-Ph-VO-Ph-Z、R-Xa-2-Ph-G-Ph-Z, R-Xa-2-Ph-G-Ph1-Z, R
-Xa-2-Ph-G-Ph3-Z, R-Xa-2-Ph-T-Ph-Z, R-Xa-2-Ph-T-Ph
1-Z, R-Xa-2-Ph-T-Ph3-Z, R-Xa-2-Ph-VO-Ph-Z, R-Xa-2-
Ph-VO-Ph1-Z, R-Xa-2-Ph-VO-Ph3-Z, R-Xa-2-Ph-Cy-Z, R
-Xa-2-Ph-Ph-Z, R-Xa-2-Ph-Ph1-Z, R-Xa-2-Ph-Ph3-Z, R
-Xa-2-Ph1-G-Ph-Z, R-Xa-2-Ph1-G-Ph1-Z, R-Xa-2-Ph1-G
-Ph3-Z, R-Xa-2-Ph1-T-Ph-Z, R-Xa-2-Ph1-T-Ph1-Z, RX
a-2-Ph1-T-Ph3-Z, R-Xa-2-Ph1-VO-Ph-Z, R-Xa-2-Ph1-VO
-Ph1-Z, R-Xa-2-Ph1-VO-Ph3-Z, R-Xa-2-Ph1-Cy-Z, R-Xa
-2-Ph1-Ph-Z, R-Xa-2-Ph1-Ph1-Z, R-Xa-2-Ph1-Ph3-Z, R
-Xa-2-Ph3-G-Ph-Z, R-Xa-2-Ph3-G-Ph1-Z, R-Xa-2-Ph3-G
-Ph3-Z, R-Xa-2-Ph3-T-Ph-Z, R-Xa-2-Ph3-T-Ph1-Z, RX
a-2-Ph3-T-Ph3-Z, R-Xa-2-Ph3-VO-Ph-Z, R-Xa-2-Ph3-VO
-Ph1-Z, R-Xa-2-Ph3-VO-Ph3-Z, R-Xa-2-Ph3-Cy-Z, R-Xa
-2-Ph3-Ph-Z, R-Xa-2-Ph3-Ph1-Z, R-Xa-2-Ph3-Ph3-Z, R
-Xa-G-Ph-G-Ph-Z, R-Xa-G-Ph-G-Ph1-Z, R-Xa-G-Ph-G-Ph
3-Z, R-Xa-G-Ph-T-Ph-Z, R-Xa-G-Ph-T-Ph1-Z, R-Xa-GP
hT-Ph3-Z, R-Xa-G-Ph-VO-Ph-Z, R-Xa-G-Ph-VO-Ph1-Z,
R-Xa-G-Ph-VO-Ph3-Z, R-Xa-G-Ph-Cy-Z, R-Xa-G-Ph-Ph-
Z, R-Xa-G-Ph-Ph1-Z, R-Xa-G-Ph-Ph3-Z, R-Xa-G-Ph1-G-
Ph-Z, R-Xa-G-Ph1-G-Ph1-Z, R-Xa-G-Ph1-G-Ph3-Z, R-Xa
-G-Ph1-T-Ph-Z, R-Xa-G-Ph1-T-Ph1-Z, R-Xa-G-Ph1-T-Ph
3-Z, R-Xa-G-Ph1-VO-Ph-Z, R-Xa-G-Ph1-VO-Ph1-Z, R-Xa
-G-Ph1-VO-Ph3-Z, R-Xa-G-Ph1-Cy-Z, R-Xa-G-Ph1-Ph-
Z, R-Xa-G-Ph1-Ph1-Z, R-Xa-G-Ph1-Ph3-Z, R-Xa-G-Ph3-
G-Ph-Z, R-Xa-G-Ph3-G-Ph1-Z, R-Xa-G-Ph3-G-Ph3-Z, R-
Xa-G-Ph3-T-Ph-Z, R-Xa-G-Ph3-T-Ph1-Z, R-Xa-G-Ph3-T-
Ph3-Z, R-Xa-G-Ph3-VO-Ph-Z, R-Xa-G-Ph3-VO-Ph1-Z, R-
Xa-G-Ph3-VO-Ph3-Z, R-Xa-G-Ph3-Cy-Z, R-Xa-G-Ph3-Ph-
Z, R-Xa-G-Ph3-Ph1-Z, R-Xa-G-Ph3-Ph3-Z, R-Xa-T-Ph-G
-Ph-Z, R-Xa-T-Ph-G-Ph1-Z, R-Xa-T-Ph-G-Ph3-Z, R-Xa-
T-Ph-T-Ph-Z, R-Xa-T-Ph-T-Ph1-Z, R-Xa-T-Ph-T-Ph3-
Z, R-Xa-T-Ph-VO-Ph-Z,

【００４０】R-Xa-T-Ph-VO-Ph1-Z、R-Xa-T-Ph-VO-Ph3-
Z、R-Xa-T-Ph-Cy-Z、R-Xa-T-Ph-Ph-Z、R-Xa-T-Ph-Ph1-
Z、R-Xa-T-Ph-Ph3-Z、R-Xa-T-Ph1-G-Ph-Z、R-Xa-T-Ph1-
G-Ph1-Z、R-Xa-T-Ph1-G-Ph3-Z、R-Xa-T-Ph1-T-Ph-Z、R-
Xa-T-Ph1-T-Ph1-Z、R-Xa-T-Ph1-T-Ph3-Z、R-Xa-T-Ph1-V
O-Ph-Z、R-Xa-T-Ph1-VO-Ph1-Z、R-Xa-T-Ph1-VO-Ph3-Z、
R-Xa-T-Ph1-Cy-Z、R-Xa-T-Ph1-Ph-Z、R-Xa-T-Ph1-Ph1-
Z、R-Xa-T-Ph1-Ph3-Z、R-Xa-T-Ph3-G-Ph-Z、R-Xa-T-Ph3
-G-Ph1-Z、R-Xa-T-Ph3-G-Ph3-Z、R-Xa-T-Ph3-T-Ph-Z、R
-Xa-T-Ph3-T-Ph1-Z、R-Xa-T-Ph3-T-Ph3-Z、R-Xa-T-Ph3-
VO-Ph-Z、R-Xa-T-Ph3-VO-Ph1-Z、R-Xa-T-Ph3-VO-Ph3-
Z、R-Xa-T-Ph3-Cy-Z、R-Xa-T-Ph3-Ph-Z、R-Xa-T-Ph3-Ph
1-Z、R-Xa-T-Ph3-Ph3-Z、R-Xa-VO-Ph-G-Ph-Z、R-Xa-VO-
Ph-G-Ph1-Z、R-Xa-VO-Ph-G-Ph3-Z、R-Xa-VO-Ph-T-Ph-
Z、R-Xa-VO-Ph-T-Ph1-Z、R-Xa-VO-Ph-T-Ph3-Z、R-Xa-VO
-Ph-VO-Ph-Z、R-Xa-VO-Ph-VO-Ph1-Z、R-Xa-VO-Ph-VO-Ph
3-Z、R-Xa-VO-Ph-Cy-Z、R-Xa-VO-Ph-Ph-Z、R-Xa-VO-Ph-
Ph1-Z、R-Xa-VO-Ph-Ph3-Z、R-Xa-VO-Ph1-G-Ph-Z、R-Xa-
VO-Ph1-G-Ph1-Z、R-Xa-VO-Ph1-G-Ph3-Z、R-Xa-VO-Ph1-T
-Ph-Z、R-Xa-VO-Ph1-T-Ph1-Z、R-Xa-VO-Ph1-T-Ph3-Z、R
-Xa-VO-Ph1-VO-Ph-Z、R-Xa-VO-Ph1-VO-Ph1-Z、R-Xa-VO-
Ph1-VO-Ph3-Z、R-Xa-VO-Ph1-Cy-Z、R-Xa-VO-Ph1-Ph-Z、
R-Xa-VO-Ph1-Ph1-Z、R-Xa-VO-Ph1-Ph3-Z、R-Xa-VO-Ph3-
G-Ph-Z、R-Xa-VO-Ph3-G-Ph1-Z、R-Xa-VO-Ph3-G-Ph3-Z、
R-Xa-VO-Ph3-T-Ph-Z、R-Xa-VO-Ph3-T-Ph1-Z、R-Xa-VO-P
h3-T-Ph3-Z、R-Xa-VO-Ph3-VO-Ph-Z、R-Xa-VO-Ph3-VO-Ph
1-Z、R-Xa-VO-Ph3-VO-Ph3-Z、R-Xa-VO-Ph3-Cy-Z、R-Xa-
VO-Ph3-Ph-Z、R-Xa-VO-Ph3-Ph1-Z、R-Xa-VO-Ph3-Ph3-
Z、R-Xa-Cy-2-Cy-Z、R-Xa-Cy-Cy-Z、R-Xa-Ph-G-Ph-Z、R
-Xa-Ph-G-Ph1-Z、R-Xa-Ph-G-Ph3-Z、R-Xa-Ph-T-Ph-Z、R
-Xa-Ph-T-Ph1-Z、R-Xa-Ph-T-Ph3-Z、R-Xa-Ph-VO-Ph-Z、
R-Xa-Ph-VO-Ph1-Z、R-Xa-Ph-VO-Ph3-Z、R-Xa-Ph-Cy-Z、
R-Xa-Ph-Ph-Z、R-Xa-Ph-Ph1-Z、R-Xa-Ph-Ph3-Z、R-Xa-P
h1-G-Ph-Z、R-Xa-Ph1-G-Ph1-Z、R-Xa-Ph1-G-Ph3-Z、R-X
a-Ph1-T-Ph-Z、R-Xa-Ph1-T-Ph1-Z、R-Xa-Ph1-T-Ph3-Z、
R-Xa-Ph1-VO-Ph-Z、R-Xa-Ph1-VO-Ph1-Z、R-Xa-Ph1-VO-P
h3-Z、R-Xa-Ph1-Cy-Z、R-Xa-Ph1-Ph-Z、R-Xa-Ph1-Ph1-
Z、R-Xa-Ph1-Ph3-Z、R-Xa-Ph3-G-Ph-Z、R-Xa-Ph3-G-Ph1
-Z、R-Xa-Ph3-G-Ph3-Z、R-Xa-Ph3-T-Ph-Z、R-Xa-Ph3-T-
Ph1-Z、R-Xa-Ph3-T-Ph3-Z、R-Xa-Ph3-VO-Ph-Z、R-Xa-Ph
3-VO-Ph1-Z、R-Xa-Ph3-VO-Ph3-Z、R-Xa-Ph3-Cy-Z、R-Xa
-Ph3-Ph-Z、R-Xa-Ph3-Ph1-Z、R-Xa-Ph3-Ph3-Z R-Xb-Cy-2-Cy-Z、R-Xb-Cy-Cy-Z、R-Xb-Ph-G-Ph-Z、R-Xb
-Ph-G-Ph1-Z、R-Xb-Ph-G-Ph3-Z、R-Xb-Ph-T-Ph-Z、R-Xb
-Ph-T-Ph1-Z、R-Xb-Ph-T-Ph3-Z、R-Xb-Ph-VO-Ph-Z、R-X
b-Ph-VO-Ph1-Z、R-Xb-Ph-VO-Ph3-Z、R-Xb-Ph-Cy-Z、R-X
b-Ph-Ph-Z、R-Xb-Ph-Ph1-Z、R-Xb-Ph-Ph3-Z、R-Xb-Ph1-
G-Ph-Z、R-Xb-Ph1-G-Ph1-Z、R-Xb-Ph1-G-Ph3-Z、R-Xb-P
h1-T-Ph-Z、R-Xb-Ph1-T-Ph1-Z、R-Xb-Ph1-T-Ph3-Z、R-X
b-Ph1-VO-Ph-Z、R-Xb-Ph1-VO-Ph1-Z、R-Xb-Ph1-VO-Ph3-
Z、R-Xb-Ph1-Cy-Z、R-Xb-Ph1-Ph-Z、R-Xb-Ph1-Ph1-Z、R
-Xb-Ph1-Ph3-Z、R-Xb-Ph3-G-Ph-Z、R-Xb-Ph3-G-Ph1-Z、
R-Xb-Ph3-G-Ph3-Z、R-Xb-Ph3-T-Ph-Z、R-Xb-Ph3-T-Ph1-
Z、R-Xb-Ph3-T-Ph3-Z、R-Xb-Ph3-VO-Ph-Z、R-Xb-Ph3-VO
-Ph1-Z、R-Xb-Ph3-VO-Ph3-Z、R-Xb-Ph3-Cy-Z、R-Xb-Ph3
-Ph-Z、R-Xb-Ph3-Ph1-Z、R-Xb-Ph3-Ph3-Z、R-Cy-2-Xa-T
-Ph-T-Cy-Z、R-Cy-2-Xa-T-Ph-Cy-Z、R-Cy-2-Xa-VO-Ph-2
-Cy-Z、R-Cy-2-Xa-VO-Ph-T-Cy-Z、R-Cy-2-Xa-Ph1-2-Ph3
-Z、R-Cy-2-Xa-Ph1-T-Ph3-Z、R-Cy-2-Xa-Ph1-Ph3-Z、R-
Cy-J-Xa-T-Ph-2-Cy-Z、R-Cy-J-Xa-Ph1-T-Cy-Z、R-Cy-J-
Xa-Ph1-Cy-Z、R-Cy-VO-Xa-VO-Ph-Cy-Z、R-Cy-VO-Xb-Ph-
2-Cy-Z、R-Cy-VO-Xa-Ph-T-Cy-Z、R-Cy-VO-Xb-Ph-Cy-Z、
R-Cy-Xa-T-Cy-2-Cy-Z、R-Cy-Xa-T-Cy-T-Cy-Z、R-Cy-Xa-
T-Cy-Cy-Z、R-Cy-Xa-VO-Cy-2-Cy-Z、R-Cy-Xa-VO-Cy-T-C
y-Z、R-Cy-Xa-VO-Cy-Cy-Z、R-Cy-Xa-Cy-2-Cy-Z、R-Cy-X
a-Cy-Cy-Z、R-Ph-2-Xa-Cy-2-Ph-Z、R-Ph-2-Xa-Cy-Ph-
Z、R-Ph-2-Xa-T-Ph1-2-Cy-Z、R-Ph-2-Xa-T-Ph1-T-Cy-
Z、R-Ph-J-Xa-Cy-2-Ph-Z、R-Ph-J-Xa-Cy-T-Ph-Z、R-Ph-
J-Xa-Cy-Ph-Z、R-Ph-T-Xa-Cy-2-Ph-Z、R-Ph-T-Xa-Cy-T-
Ph-Z、R-Ph-T-Xa-Ph-T-Ph-Z、R-Ph-T-Xa-Ph-Ph-Z、R-Ph
-VO-Xa-Ph-2-Ph-Z、R-Ph-VO-Xa-Ph-T-Ph-Z、R-Ph-VO-Xa
-Ph-Ph-Z、R-Ph-Xa-T-Ph1-Cy-Z、R-Ph-Xa-VO-Ph1-2-Cy-
Z、R-Ph-Xa-VO-Ph1-T-Cy-Z、R-Ph-Xa-VO-Ph1-Cy-Z、R-P
h1-2-Xa-Ph1-2-Ph-Z、R-Ph1-2-Xa-Ph1-T-Ph-Z、R-Ph1-2
-Xa-Ph1-Ph-Z、R-Ph1-J-Xa-Ph1-2-Ph-Z、R-Ph1-J-Xa-Ph
1-T-Ph-Z、R-Ph1-J-Xa-Ph1-Ph-Z、R-Ph1-T-Xa-Cy-Ph3-
Z、R-Ph1-T-Xa-Ph1-2-Ph-Z、R-Ph1-T-Xa-Ph1-T-Ph-Z、R
-Ph1-VO-Xa-Cy-2-Ph3-Z、R-Ph1-VO-Xa-Cy-T-Ph3-Z、R-P
h1-VO-Xa-Cy-Ph3-Z、R-Ph1-Xa-Ph-2-Ph-Z、R-Ph1-Xa-Ph
-T-Ph-Z、R-Ph1-Xa-Ph-Ph-Z、R-Ph1-Xa-Ph1-Ph-Z、R-Ph
3-2-Xa-Cy-2-Ph3-Z、R-Ph3-2-Xa-Ph-T-Ph3-Z、R-Ph3-2-
Xa-Ph-Ph3-Z、R-Ph3-J-Xa-Ph-2-Ph3-Z、R-Ph3-J-Xa-Ph-
T-Ph3-Z、R-Ph3-J-Xa-Ph-Ph3-Z、R-Ph3-T-Xa-Ph-2-Ph3-
Z、R-Ph3-T-Xa-Ph-T-Ph3-Z、R-Ph3-T-Xa-Ph-Ph3-Z、R-P
h3-VO-Xa-Ph-2-Ph3-Z、R-Ph3-VO-Xa-Ph1-T-Ph3-Z、R-Ph
3-VO-Xa-Ph1-Ph3-Z、R-Ph3-Xa-Cy-2-Ph3-Z、R-Ph3-Xa-C
y-T-Ph3-Z、R-Ph3-Xa-Cy-Ph3-Z、R-Xa-T-Ph-VO-Ph1-Z, R-Xa-T-Ph-VO-Ph3-
Z, R-Xa-T-Ph-Cy-Z, R-Xa-T-Ph-Ph-Z, R-Xa-T-Ph-Ph1-
Z, R-Xa-T-Ph-Ph3-Z, R-Xa-T-Ph1-G-Ph-Z, R-Xa-T-Ph1-
G-Ph1-Z, R-Xa-T-Ph1-G-Ph3-Z, R-Xa-T-Ph1-T-Ph-Z, R-
Xa-T-Ph1-T-Ph1-Z, R-Xa-T-Ph1-T-Ph3-Z, R-Xa-T-Ph1-V
O-Ph-Z, R-Xa-T-Ph1-VO-Ph1-Z, R-Xa-T-Ph1-VO-Ph3-Z,
R-Xa-T-Ph1-Cy-Z, R-Xa-T-Ph1-Ph-Z, R-Xa-T-Ph1-Ph1-
Z, R-Xa-T-Ph1-Ph3-Z, R-Xa-T-Ph3-G-Ph-Z, R-Xa-T-Ph3
-G-Ph1-Z, R-Xa-T-Ph3-G-Ph3-Z, R-Xa-T-Ph3-T-Ph-Z, R
-Xa-T-Ph3-T-Ph1-Z, R-Xa-T-Ph3-T-Ph3-Z, R-Xa-T-Ph3-
VO-Ph-Z, R-Xa-T-Ph3-VO-Ph1-Z, R-Xa-T-Ph3-VO-Ph3-
Z, R-Xa-T-Ph3-Cy-Z, R-Xa-T-Ph3-Ph-Z, R-Xa-T-Ph3-Ph
1-Z, R-Xa-T-Ph3-Ph3-Z, R-Xa-VO-Ph-G-Ph-Z, R-Xa-VO-
Ph-G-Ph1-Z, R-Xa-VO-Ph-G-Ph3-Z, R-Xa-VO-Ph-T-Ph-
Z, R-Xa-VO-Ph-T-Ph1-Z, R-Xa-VO-Ph-T-Ph3-Z, R-Xa-VO
-Ph-VO-Ph-Z, R-Xa-VO-Ph-VO-Ph1-Z, R-Xa-VO-Ph-VO-Ph
3-Z, R-Xa-VO-Ph-Cy-Z, R-Xa-VO-Ph-Ph-Z, R-Xa-VO-Ph-
Ph1-Z, R-Xa-VO-Ph-Ph3-Z, R-Xa-VO-Ph1-G-Ph-Z, R-Xa-
VO-Ph1-G-Ph1-Z, R-Xa-VO-Ph1-G-Ph3-Z, R-Xa-VO-Ph1-T
-Ph-Z, R-Xa-VO-Ph1-T-Ph1-Z, R-Xa-VO-Ph1-T-Ph3-Z, R
-Xa-VO-Ph1-VO-Ph-Z, R-Xa-VO-Ph1-VO-Ph1-Z, R-Xa-VO-
Ph1-VO-Ph3-Z, R-Xa-VO-Ph1-Cy-Z, R-Xa-VO-Ph1-Ph-Z,
R-Xa-VO-Ph1-Ph1-Z, R-Xa-VO-Ph1-Ph3-Z, R-Xa-VO-Ph3-
G-Ph-Z, R-Xa-VO-Ph3-G-Ph1-Z, R-Xa-VO-Ph3-G-Ph3-Z,
R-Xa-VO-Ph3-T-Ph-Z, R-Xa-VO-Ph3-T-Ph1-Z, R-Xa-VO-P
h3-T-Ph3-Z, R-Xa-VO-Ph3-VO-Ph-Z, R-Xa-VO-Ph3-VO-Ph
1-Z, R-Xa-VO-Ph3-VO-Ph3-Z, R-Xa-VO-Ph3-Cy-Z, R-Xa-
VO-Ph3-Ph-Z, R-Xa-VO-Ph3-Ph1-Z, R-Xa-VO-Ph3-Ph3-
Z, R-Xa-Cy-2-Cy-Z, R-Xa-Cy-Cy-Z, R-Xa-Ph-G-Ph-Z, R
-Xa-Ph-G-Ph1-Z, R-Xa-Ph-G-Ph3-Z, R-Xa-Ph-T-Ph-Z, R
-Xa-Ph-T-Ph1-Z, R-Xa-Ph-T-Ph3-Z, R-Xa-Ph-VO-Ph-Z,
R-Xa-Ph-VO-Ph1-Z, R-Xa-Ph-VO-Ph3-Z, R-Xa-Ph-Cy-Z,
R-Xa-Ph-Ph-Z, R-Xa-Ph-Ph1-Z, R-Xa-Ph-Ph3-Z, R-Xa-P
h1-G-Ph-Z, R-Xa-Ph1-G-Ph1-Z, R-Xa-Ph1-G-Ph3-Z, RX
a-Ph1-T-Ph-Z, R-Xa-Ph1-T-Ph1-Z, R-Xa-Ph1-T-Ph3-Z,
R-Xa-Ph1-VO-Ph-Z, R-Xa-Ph1-VO-Ph1-Z, R-Xa-Ph1-VO-P
h3-Z, R-Xa-Ph1-Cy-Z, R-Xa-Ph1-Ph-Z, R-Xa-Ph1-Ph1-
Z, R-Xa-Ph1-Ph3-Z, R-Xa-Ph3-G-Ph-Z, R-Xa-Ph3-G-Ph1
-Z, R-Xa-Ph3-G-Ph3-Z, R-Xa-Ph3-T-Ph-Z, R-Xa-Ph3-T-
Ph1-Z, R-Xa-Ph3-T-Ph3-Z, R-Xa-Ph3-VO-Ph-Z, R-Xa-Ph
3-VO-Ph1-Z, R-Xa-Ph3-VO-Ph3-Z, R-Xa-Ph3-Cy-Z, R-Xa
-Ph3-Ph-Z, R-Xa-Ph3-Ph1-Z, R-Xa-Ph3-Ph3-Z R-Xb-Cy-2-Cy-Z, R-Xb-Cy-Cy-Z, R- Xb-Ph-G-Ph-Z, R-Xb
-Ph-G-Ph1-Z, R-Xb-Ph-G-Ph3-Z, R-Xb-Ph-T-Ph-Z, R-Xb
-Ph-T-Ph1-Z, R-Xb-Ph-T-Ph3-Z, R-Xb-Ph-VO-Ph-Z, RX
b-Ph-VO-Ph1-Z, R-Xb-Ph-VO-Ph3-Z, R-Xb-Ph-Cy-Z, RX
b-Ph-Ph-Z, R-Xb-Ph-Ph1-Z, R-Xb-Ph-Ph3-Z, R-Xb-Ph1-
G-Ph-Z, R-Xb-Ph1-G-Ph1-Z, R-Xb-Ph1-G-Ph3-Z, R-Xb-P
h1-T-Ph-Z, R-Xb-Ph1-T-Ph1-Z, R-Xb-Ph1-T-Ph3-Z, RX
b-Ph1-VO-Ph-Z, R-Xb-Ph1-VO-Ph1-Z, R-Xb-Ph1-VO-Ph3-
Z, R-Xb-Ph1-Cy-Z, R-Xb-Ph1-Ph-Z, R-Xb-Ph1-Ph1-Z, R
-Xb-Ph1-Ph3-Z, R-Xb-Ph3-G-Ph-Z, R-Xb-Ph3-G-Ph1-Z,
R-Xb-Ph3-G-Ph3-Z, R-Xb-Ph3-T-Ph-Z, R-Xb-Ph3-T-Ph1-
Z, R-Xb-Ph3-T-Ph3-Z, R-Xb-Ph3-VO-Ph-Z, R-Xb-Ph3-VO
-Ph1-Z, R-Xb-Ph3-VO-Ph3-Z, R-Xb-Ph3-Cy-Z, R-Xb-Ph3
-Ph-Z, R-Xb-Ph3-Ph1-Z, R-Xb-Ph3-Ph3-Z, R-Cy-2-Xa-T
-Ph-T-Cy-Z, R-Cy-2-Xa-T-Ph-Cy-Z, R-Cy-2-Xa-VO-Ph-2
-Cy-Z, R-Cy-2-Xa-VO-Ph-T-Cy-Z, R-Cy-2-Xa-Ph1-2-Ph3
-Z, R-Cy-2-Xa-Ph1-T-Ph3-Z, R-Cy-2-Xa-Ph1-Ph3-Z, R-
Cy-J-Xa-T-Ph-2-Cy-Z, R-Cy-J-Xa-Ph1-T-Cy-Z, R-Cy-J-
Xa-Ph1-Cy-Z, R-Cy-VO-Xa-VO-Ph-Cy-Z, R-Cy-VO-Xb-Ph-
2-Cy-Z, R-Cy-VO-Xa-Ph-T-Cy-Z, R-Cy-VO-Xb-Ph-Cy-Z,
R-Cy-Xa-T-Cy-2-Cy-Z, R-Cy-Xa-T-Cy-T-Cy-Z, R-Cy-Xa-
T-Cy-Cy-Z, R-Cy-Xa-VO-Cy-2-Cy-Z, R-Cy-Xa-VO-Cy-TC
yZ, R-Cy-Xa-VO-Cy-Cy-Z, R-Cy-Xa-Cy-2-Cy-Z, R-Cy-X
a-Cy-Cy-Z, R-Ph-2-Xa-Cy-2-Ph-Z, R-Ph-2-Xa-Cy-Ph-
Z, R-Ph-2-Xa-T-Ph1-2-Cy-Z, R-Ph-2-Xa-T-Ph1-T-Cy-
Z, R-Ph-J-Xa-Cy-2-Ph-Z, R-Ph-J-Xa-Cy-T-Ph-Z, R-Ph-
J-Xa-Cy-Ph-Z, R-Ph-T-Xa-Cy-2-Ph-Z, R-Ph-T-Xa-Cy-T-
Ph-Z, R-Ph-T-Xa-Ph-T-Ph-Z, R-Ph-T-Xa-Ph-Ph-Z, R-Ph
-VO-Xa-Ph-2-Ph-Z, R-Ph-VO-Xa-Ph-T-Ph-Z, R-Ph-VO-Xa
-Ph-Ph-Z, R-Ph-Xa-T-Ph1-Cy-Z, R-Ph-Xa-VO-Ph1-2-Cy-
Z, R-Ph-Xa-VO-Ph1-T-Cy-Z, R-Ph-Xa-VO-Ph1-Cy-Z, RP
h1-2-Xa-Ph1-2-Ph-Z, R-Ph1-2-Xa-Ph1-T-Ph-Z, R-Ph1-2
-Xa-Ph1-Ph-Z, R-Ph1-J-Xa-Ph1-2-Ph-Z, R-Ph1-J-Xa-Ph
1-T-Ph-Z, R-Ph1-J-Xa-Ph1-Ph-Z, R-Ph1-T-Xa-Cy-Ph3-
Z, R-Ph1-T-Xa-Ph1-2-Ph-Z, R-Ph1-T-Xa-Ph1-T-Ph-Z, R
-Ph1-VO-Xa-Cy-2-Ph3-Z, R-Ph1-VO-Xa-Cy-T-Ph3-Z, RP
h1-VO-Xa-Cy-Ph3-Z, R-Ph1-Xa-Ph-2-Ph-Z, R-Ph1-Xa-Ph
-T-Ph-Z, R-Ph1-Xa-Ph-Ph-Z, R-Ph1-Xa-Ph1-Ph-Z, R-Ph
3-2-Xa-Cy-2-Ph3-Z, R-Ph3-2-Xa-Ph-T-Ph3-Z, R-Ph3-2-
Xa-Ph-Ph3-Z, R-Ph3-J-Xa-Ph-2-Ph3-Z, R-Ph3-J-Xa-Ph-
T-Ph3-Z, R-Ph3-J-Xa-Ph-Ph3-Z, R-Ph3-T-Xa-Ph-2-Ph3-
Z, R-Ph3-T-Xa-Ph-T-Ph3-Z, R-Ph3-T-Xa-Ph-Ph3-Z, RP
h3-VO-Xa-Ph-2-Ph3-Z, R-Ph3-VO-Xa-Ph1-T-Ph3-Z, R-Ph
3-VO-Xa-Ph1-Ph3-Z, R-Ph3-Xa-Cy-2-Ph3-Z, R-Ph3-Xa-C
yT-Ph3-Z, R-Ph3-Xa-Cy-Ph3-Z,

【００４１】5Xa-F、7Xa-CN、7-Ca-OV-Ca-D2-Xc-3a-Ca-
4-Ca-F、9-Cb-D-Cb-3-Xd-3b-Cb-Cb-OCF3、2O-Oc-2D-Oc-
3a-Xb-4-Oc-1O-Oc-CN、5O-Od-D2-Od-3b-Xc-Od-O1-Od-C
l、7O-Bc-3-Bc-Xd-1O-Bc-OV-Bc-OCHF2、1O-3-Dc-3a-Dc-
4-Xb-O1-Dc-D-Dc-H、1d2-Ph2-3b-Ph2-1O-Xc-OV-Ph2-2D-
Ph2-3、d(3)1O-Ph4-4-Ph4-O1-Xd-D-Ph4-D2-Ph4-4、6-Ph
5-1O-Ph5-OV-Xb-2D-Ph5-3-Ph5-5、7-Ph6-O1-Ph6-D-Xc-D
2-Ph6-3a-Ph6-0d1、9-Ph7-Ph7-2D-Xd-3-Ph7-3b-Ph7-0d
3、2O-Ph8-OV-Ph8-D2-Xb-3a-Ph8-4-Ph8-1d3、5O-Ya-D-Y
a-3-Xc-3b-Ya-Ya-1d1、7O-Yb-2D-Yb-3a-Xd-4-Yb-1O-Yb-
3O、1O-3-Ma-D2-Ma-3b-Xb-Ma-O1-Ma-、1d2-Mb-3-Mb-Xc-
1O-Mb-OV-Mb-F、d(3)1O-Pr-3a-Pr-4-Xd-O1-Pr-D-Pr-OCF
3、6-Pr2-3b-Pr2-1O-Xb-OV-Pr2-2D-Pr2-CN、7-Te-4-Te-
O1-Xc-D-Te-D2-Te-Cl、9-Te1-1O-Te1-OV-Xd-2D-Te1-3-T
e1-OCHF2、2O-Te2-O1-Te2-D-Xb-D2-Te2-3a-Te2-H、5O-T
e3-Te3-2D-Xc-3-Te3-3b-Te3-3、7O-Tb-OV-Tb-D2-Xd-3a-
Tb-4-Tb-4、1O-3-Tb1-D-Tb1-3-Xb-3b-Tb1-Tb1-5、1d2-T
b2-2D-Tb2-3a-Xc-4-Tb2-1O-Tb2-0d1、d(3)1O-Tb3-D2-Tb
3-3b-Xd-Tb3-O1-Tb3-0d3、6-Np-3-Np-Xb-1O-Np-OV-Np-1
d3、7-Np1-3a-Np1-4-Xc-O1-Np1-D-Np1-1d1、9-Np2-3b-N
p2-1O-Xd-OV-Np2-2D-Np2-3O、2O-Np3-4-Np3-O1-Xb-D-Np
3-D2-Np3-、5O-Np4-1O-Np4-OV-Xc-2D-Np4-3-Np4-F、7O-
Np5-O1-Np5-D-Xd-D2-Np5-3a-Np5-OCF3、1O-3-Np6-Np6-2
D-Xb-3-Np6-3b-Np6-CN、1d2-Na1-OV-Na1-D2-Xc-3a-Na1-
4-Na1-Cl、d(3)1O-Na2-D-Na2-3-Xd-3b-Na2-Na2-OCHF2、
6-Na3-2D-Na3-3a-Xb-4-Na3-1O-Na3-H、7-Na4-D2-Na4-3b
-Xc-Na4-O1-Na4-3、9-Na5-3-Na5-Xd-1O-Na5-OV-Na5-4、
2O-Na6-3a-Na6-4-Xb-O1-Na6-D-Na6-5、5O-Nd1-3b-Nd1-1
O-Xc-OV-Nd1-2D-Nd1-0d1、7O-Nd2-4-Nd2-O1-Xd-D-Nd2-D
2-Nd2-0d3、1O-3-Nd3-1O-Nd3-OV-Xb-2D-Nd3-3-Nd3-1d
3、1d2-Nd4-O1-Nd4-D-Xc-D2-Nd4-3a-Nd4-1d1、d(3)1O-N
d5-2-Nd5-3-Xd-3-Nd5-2-Nd5-3O ただし、上記各例示式中、R及びZは一般式(1)と同義を表
す。5Xa-F, 7Xa-CN, 7-Ca-OV-Ca-D2-Xc-3a-Ca-
4-Ca-F, 9-Cb-D-Cb-3-Xd-3b-Cb-Cb-OCF3, 2O-Oc-2D-Oc-
3a-Xb-4-Oc-1O-Oc-CN, 5O-Od-D2-Od-3b-Xc-Od-O1-Od-C
l, 7O-Bc-3-Bc-Xd-1O-Bc-OV-Bc-OCHF2, 1O-3-Dc-3a-Dc-
4-Xb-O1-Dc-D-Dc-H, 1d2-Ph2-3b-Ph2-1O-Xc-OV-Ph2-2D-
Ph2-3, d (3) 1O-Ph4-4-Ph4-O1-Xd-D-Ph4-D2-Ph4-4, 6-Ph
5-1O-Ph5-OV-Xb-2D-Ph5-3-Ph5-5, 7-Ph6-O1-Ph6-D-Xc-D
2-Ph6-3a-Ph6-0d1, 9-Ph7-Ph7-2D-Xd-3-Ph7-3b-Ph7-0d
3, 2O-Ph8-OV-Ph8-D2-Xb-3a-Ph8-4-Ph8-1d3, 5O-Ya-DY
a-3-Xc-3b-Ya-Ya-1d1, 7O-Yb-2D-Yb-3a-Xd-4-Yb-1O-Yb-
3O, 1O-3-Ma-D2-Ma-3b-Xb-Ma-O1-Ma-, 1d2-Mb-3-Mb-Xc-
1O-Mb-OV-Mb-F, d (3) 1O-Pr-3a-Pr-4-Xd-O1-Pr-D-Pr-OCF
3, 6-Pr2-3b-Pr2-1O-Xb-OV-Pr2-2D-Pr2-CN, 7-Te-4-Te-
O1-Xc-D-Te-D2-Te-Cl, 9-Te1-1O-Te1-OV-Xd-2D-Te1-3-T
e1-OCHF2, 2O-Te2-O1-Te2-D-Xb-D2-Te2-3a-Te2-H, 5O-T
e3-Te3-2D-Xc-3-Te3-3b-Te3-3, 7O-Tb-OV-Tb-D2-Xd-3a-
Tb-4-Tb-4, 1O-3-Tb1-D-Tb1-3-Xb-3b-Tb1-Tb1-5, 1d2-T
b2-2D-Tb2-3a-Xc-4-Tb2-1O-Tb2-0d1, d (3) 1O-Tb3-D2-Tb
3-3b-Xd-Tb3-O1-Tb3-0d3, 6-Np-3-Np-Xb-1O-Np-OV-Np-1
d3, 7-Np1-3a-Np1-4-Xc-O1-Np1-D-Np1-1d1, 9-Np2-3b-N
p2-1O-Xd-OV-Np2-2D-Np2-3O, 2O-Np3-4-Np3-O1-Xb-D-Np
3-D2-Np3-, 5O-Np4-1O-Np4-OV-Xc-2D-Np4-3-Np4-F, 7O-
Np5-O1-Np5-D-Xd-D2-Np5-3a-Np5-OCF3, 1O-3-Np6-Np6-2
D-Xb-3-Np6-3b-Np6-CN, 1d2-Na1-OV-Na1-D2-Xc-3a-Na1-
4-Na1-Cl, d (3) 1O-Na2-D-Na2-3-Xd-3b-Na2-Na2-OCHF2,
6-Na3-2D-Na3-3a-Xb-4-Na3-1O-Na3-H, 7-Na4-D2-Na4-3b
-Xc-Na4-O1-Na4-3, 9-Na5-3-Na5-Xd-1O-Na5-OV-Na5-4,
2O-Na6-3a-Na6-4-Xb-O1-Na6-D-Na6-5, 5O-Nd1-3b-Nd1-1
O-Xc-OV-Nd1-2D-Nd1-0d1, 7O-Nd2-4-Nd2-O1-Xd-D-Nd2-D
2-Nd2-0d3, 1O-3-Nd3-1O-Nd3-OV-Xb-2D-Nd3-3-Nd3-1d
3, 1d2-Nd4-O1-Nd4-D-Xc-D2-Nd4-3a-Nd4-1d1, d (3) 1O-N
d5-2-Nd5-3-Xd-3-Nd5-2-Nd5-3O However, in each of the above formulas, R and Z have the same meaning as in formula (1).

【００４２】一般式(1)の化合物は、R、A、B、C、D、
L、M、Q、T、m、n、q、t、X1、X2及びZに応じ、以下の
様に製造することができる。The compound of the general formula (1) includes R, A, B, C, D,
Depending on L, M, Q, T, m, n, q, t, X 1 , X 2 and Z, it can be manufactured as follows.

【００４３】一般式(2)General formula (2)

【化６】 (式中、X1、X2は一般式(1)と同義を表し、X3は、保護さ
れていてもよい水酸基、スルホニルオキシ基、又は一般
式(3)[Chemical 6] (In the formula, X 1 and X 2 represent the same meaning as in the general formula (1), X 3 represents an optionally protected hydroxyl group, a sulfonyloxy group, or the general formula (3).

【００４４】[0044]

【化７】 (式中、q、t、Q、T、C、D及びZは一般式(1)と同義)を表
す)で表される化合物から、特表平9-512269あるいは特
開平13-19648(以下、文献(a)と称す)等に記載と同様の
方法により、一般式(4)[Chemical 7] (In the formula, q, t, Q, T, C, D and Z represent the same as those in the general formula (1)) from a compound represented by: , Referred to as literature (a)), etc., by the same method as described in the general formula (4)

【００４５】[0045]

【化８】 (式中、X1、X2及びX3は一般式(2)と同義を表す)で表さ
れる化合物を得る。[Chemical 8] A compound represented by the formula (wherein X 1 , X 2 and X 3 have the same meanings as in formula (2)) is obtained.

【００４６】次いで、(4)で表される化合物から、文献
(a)に記載の方法、あるいはグリニャール試剤、有機亜
鉛化合物、有機リチウム試剤などの有機金属化合物等の
求核剤等との反応より、一般式(5)Next, from the compound represented by (4),
From the method described in (a) or the reaction with a nucleophile such as a Grignard reagent, an organozinc compound, an organolithium reagent, an organometallic compound, or the like, a compound represented by the general formula (5)

【化９】 (式中、R1は求核剤の有機残基を表し、X1、X2及びX3は
一般式(2)と同義を表す)で表される化合物を得る。[Chemical 9] (Wherein R 1 represents an organic residue of a nucleophile, and X 1 , X 2 and X 3 have the same meanings as in formula (2)).

【００４７】次いで(5)で表される化合物から、文献(a)
記載の方法等により一般式(6a)及び一般式(6b)Next, from the compound represented by (5), reference (a)
General formula (6a) and general formula (6b) by the method described

【化１０】 (式中、R1は求核剤の有機残基を表し、X1、X2及びX3は
一般式(2)と同義を表す)で表される化合物の混合物を得
る。当該混合物から、カラムクロマトグラフィー、再結
晶、蒸留などの分離精製を用いて、(6b)を得る。[Chemical 10] (Wherein R 1 represents an organic residue of a nucleophile, X 1 , X 2 and X 3 have the same meanings as those in the general formula (2)) to obtain a mixture of the compounds. From the mixture, (6b) is obtained using separation / purification such as column chromatography, recrystallization and distillation.

【００４８】特に一般式(5)中のR1は、一般式(6b)で表
される化合物から一般式(7)In particular, R 1 in the general formula (5) is a compound represented by the general formula (6b) and represented by the general formula (7)

【化１１】 (式中、R、m、n、A、B、L、X1、X2及びMは一般式(1)と
同義を表し、X3は一般式(2)と同義を表す)が得られるよ
うに適時選択すればよい。[Chemical 11] (In the formula, R, m, n, A, B, L, X 1 , X 2 and M represent the same meaning as in the general formula (1), and X 3 represents the same meaning as in the general formula (2)). You can make timely selections.

【００４９】一般式(4)で表される化合物と、一般式(8)The compound represented by the general formula (4) and the general formula (8)

【化１２】 [Chemical 12]

【００５０】(式中、Xは塩素原子、臭素原子又はヨウ素
原子を表し、R2は一般式(1)のRと同義を表し、m、n、
A、B及びLは一般式(1)と同義を表す。ただし、n = 0か
つm = 1のとき、Lは単結合を表し、n = 0かつm = 0のと
き、はR2は炭素数が2少ないRを表す)とから一般式(5-1)(Wherein, X represents a chlorine atom, a bromine atom or an iodine atom, R 2 has the same meaning as R in the general formula (1), and m, n,
A, B and L have the same meanings as in formula (1). However, when n = 0 and m = 1, L represents a single bond, and when n = 0 and m = 0, R 2 represents R having 2 less carbon atoms. )

【化１３】 (式中、R2、m、n、A、B及びLは一般式(8)と同義を表
し、X1、X2及びX3は一般式(2)と同義を表す)を得、次い
で前記に従い一般式(7-1)[Chemical 13] (In the formula, R 2 , m, n, A, B and L represent the same meaning as in the general formula (8), X 1 , X 2 and X 3 represent the same meaning as in the general formula (2)), and then According to the above general formula (7-1)

【化１４】 (式中、R2、m、n、A、B及びLは一般式(8)と同義を表
し、X1、X2及びX3は一般式(2)と同義を表す)を得ること
ができる。[Chemical 14] (In the formula, R 2 , m, n, A, B and L have the same meaning as in the general formula (8), and X 1 , X 2 and X 3 have the same meaning as in the general formula (2)). it can.

【００５１】また、一般式(5-1)の化合物を接触還元
し、一般式(5-2)Further, the compound of the general formula (5-1) is catalytically reduced to give the compound of the general formula (5-2)

【化１５】 (式中、R2、m、n、A、B及びLは一般式(8)と同義を表
し、X1、X2及びX3は一般式(2)と同義を表す)を得、次い
で前記に従い一般式(7-2)[Chemical 15] (In the formula, R 2 , m, n, A, B and L represent the same meaning as in the general formula (8), X 1 , X 2 and X 3 represent the same meaning as in the general formula (2)), and then According to the above general formula (7-2)

【化１６】 (式中、R2、m、n、A、B及びLは一般式(8)と同義を表
し、X1、X2及びX3は一般式(2)と同義を表す。)を得るこ
とができる。[Chemical 16] (In the formula, R 2 , m, n, A, B and L have the same meanings as in the general formula (8), and X 1 , X 2 and X 3 have the same meanings as in the general formula (2)). You can

【００５２】又は、一般式(4)で表される化合物と、一
般式(9)Alternatively, the compound represented by the general formula (4) and the compound represented by the general formula (9)

【化１７】 (式中、Xは塩素原子、臭素原子又はヨウ素原子を表し、
R2、m、n、A、B及びLは一般式(8)と同義を表す)とか
ら、一般式(5-3)[Chemical 17] (In the formula, X represents a chlorine atom, a bromine atom or an iodine atom,
R 2 , m, n, A, B and L represent the same meaning as in the general formula (8)), and the general formula (5-3)

【００５３】[0053]

【化１８】 (式中、R2、m、n、A、B及びLは一般式(8)と同義を表
し、X1、X2及びX3は一般式(2)と同義を表す)を得、次い
で前記に従い一般式(7-4)[Chemical 18] (In the formula, R 2 , m, n, A, B and L represent the same meaning as in the general formula (8), X 1 , X 2 and X 3 represent the same meaning as in the general formula (2)), and then According to the above general formula (7-4)

【化１９】 (式中、R2、m、n、A、B及びLは一般式(8)と同義を表
し、X1、X2及びX3は一般式(2)と同義を表す。)を得るこ
とができる。[Chemical 19] (In the formula, R 2 , m, n, A, B and L have the same meanings as in the general formula (8), and X 1 , X 2 and X 3 have the same meanings as in the general formula (2)). You can

【００５４】又は、一般式(4)で表される化合物と、一
般式(10a)あるいは一般式(10b)Alternatively, the compound represented by the general formula (4) and the general formula (10a) or the general formula (10b)

【化２０】 (式中、R3は炭素原子数1〜17のアルキル基又はアルケニ
ル基を表し、これらは炭素原子数1〜7のアルコキシル基
又は1〜7個のハロゲン原子によって置換されていてもよ
く、Metは亜鉛あるいはマグネシウム原子を表し、Xは塩
素原子、臭素原子又はヨウ素原子を表す)とから、一般
式(5-4)[Chemical 20] (In the formula, R 3 represents an alkyl group or an alkenyl group having 1 to 17 carbon atoms, which may be substituted by an alkoxyl group having 1 to 7 carbon atoms or a halogen atom having 1 to 7 carbon atoms, Met Represents a zinc or magnesium atom, X represents a chlorine atom, a bromine atom or an iodine atom), from the general formula (5-4)

【００５５】[0055]

【化２１】 (式中、R3は一般式(10a)と同義を表し、X1、X2及びX3は
一般式(2)と同義を表す)を得、次いで接触還元し、一般
式(5-5)[Chemical 21] (In the formula, R 3 has the same meaning as in the general formula (10a), X 1 , X 2 and X 3 have the same meaning as in the general formula (2)), and then catalytically reduced to give the general formula (5-5 )

【００５６】[0056]

【化２２】 (式中、R3は一般式(10a)と同義を表し、X1、X2及びX3は
一般式(2)と同義を表す)を得、次いで前記に従い一般式
(7-5)[Chemical formula 22] (In the formula, R 3 represents the same meaning as the general formula (10a), X 1 , X 2 and X 3 represent the same meaning as the general formula (2)), and then the general formula according to the above.
(7-5)

【００５７】[0057]

【化２３】 (式中、R3は一般式(10a)と同義を表し、X1、X2及びX3は
一般式(2)と同義を表す)を得ることができる。[Chemical formula 23] (In the formula, R 3 has the same meaning as in formula (10a), and X 1 , X 2 and X 3 have the same meaning as in formula (2)).

【００５８】このようにして得られた一般式(6b)あるい
は一般式(7)の化合物が、一般式(1)の化合物に相当する
ときには、そのまま本発明のために用いることができる
が、更に以下述べるような方法で、他の誘導体の製造に
供することも可能である。When the compound of the general formula (6b) or the general formula (7) thus obtained corresponds to the compound of the general formula (1), it can be used as it is for the present invention. It is also possible to provide for the production of other derivatives by the method described below.

【００５９】一般式(6b)あるいは一般式(7)においてX3
が水素原子あるいはハロゲン原子の場合、n-ブチルリチ
ウム等の有機リチウム化合物を用いて、あるいは、一般
式(6b)あるいは一般式(7)においてX3がハロゲン原子の
場合、マグネシウムを用いて、一般式(11)In the general formula (6b) or the general formula (7), X 3
When is a hydrogen atom or a halogen atom, an organolithium compound such as n-butyllithium is used, or when X 3 is a halogen atom in the general formula (6b) or the general formula (7), magnesium is generally used. Formula (11)

【００６０】[0060]

【化２４】 (式中、R4は一般式(6b)のR1と同義、又は、一般式(12)[Chemical formula 24] (Wherein, R 4 is synonymous with R 1 of the general formula (6b), or the general formula (12)

【化２５】 (式中、R、m、n、A、B、L及びMは一般式(1)と同義を表
す)を表し、Met1はリチウム原子、あるいは一般式(13) (式中、Xはハロゲン原子を表す)を表し、X1及びX2は一
般式(2)と同義を表す)を得、次いでこれを用いて、一般
式(1)で表される化合物を得ることができる。[Chemical 25] (In the formula, R, m, n, A, B, L and M represent the same meaning as in the general formula (1)), Met 1 is a lithium atom, or the general formula (13). (In the formula, X represents a halogen atom), X 1 and X 2 represent the same as the general formula (2)), and then using this, a compound represented by the general formula (1) Obtainable.

【００６１】一般式(11)の化合物と一般式(14)Compounds of general formula (11) and general formula (14)

【化２６】 (式中、t、D、T及びZは一般式(1)と同義を表す)とか
ら、一般式(15)[Chemical formula 26] (Wherein, t, D, T and Z represent the same meaning as in the general formula (1)), from the general formula (15)

【化２７】 (式中、R4、X1及びX2は一般式(11)と同義を表し、t、
D、T及びZは一般式(1)と同義を表す)で表される化合物
を得る。次いで、水酸基をトシル化、あるいはメシル化
した後、水素化リチウムアルミニウム等の金属水素化物
を用い、更に文献(a)に記載の方法等により一般式(7-6)[Chemical 27] (In the formula, R 4 , X 1 and X 2 represent the same meaning as in the general formula (11), t,
D, T and Z have the same meaning as in formula (1)), and thus a compound represented by the formula (1) is obtained. Then, after hydroxylating or mesylating the hydroxyl group, using a metal hydride such as lithium aluminum hydride, the general formula (7-6) by the method described in Document (a) and the like.

【化２８】 (式中、R4、X1及びX2は一般式(11)と同義を表し、t、
D、T及びZは一般式(1)と同義を表す)で表される化合物
を得ることができる。[Chemical 28] (In the formula, R 4 , X 1 and X 2 represent the same meaning as in the general formula (11), t,
D, T and Z have the same meanings as those in formula (1)), and thus a compound represented by the formula can be obtained.

【００６２】あるいは、一般式(11)の化合物とヨウ素か
ら一般式(16)Alternatively, the compound of the general formula (16) is prepared from the compound of the general formula (11) and iodine.

【化２９】 (式中、R4、X1及びX2は一般式(11)と同義を表す)を得、
次いで、一般式(17)[Chemical 29] (In the formula, R 4 , X 1 and X 2 represent the same as in the general formula (11)),
Then, the general formula (17)

【化３０】 (式中、R4、X1及びX2は一般式(11)と同義を表し、t、
C、D、T及びZは一般式(1)と同義を表す)との鈴木カップ
リング等、あるいは文献(a)記載の方法等により、一般
式(7-7)[Chemical 30] (In the formula, R 4 , X 1 and X 2 represent the same meaning as in the general formula (11), t,
(C, D, T and Z represent the same meaning as in the general formula (1)) Suzuki coupling or the like, or by the method described in the reference (a), the general formula (7-7)

【化３１】 (式中、R4、X1及びX2は一般式(11)と同義を表し、t、
C、D、T及びZは一般式(1)と同義を表す)を得ることがで
きる。[Chemical 31] (In the formula, R 4 , X 1 and X 2 represent the same meaning as in the general formula (11), t,
C, D, T and Z have the same meaning as in the general formula (1).

【００６３】あるいは、一般式(11)の化合物から文献
(a)に記載の方法等により一般式(18)Alternatively, from the compound of the general formula (11)
The general formula (18) according to the method described in (a)

【化３２】 (式中、R4、X1及びX2は一般式(11)と同義を表す)で表さ
れる化合物を得、次いで、過酸化水素、3級アミンオキ
シド等の適当な酸化剤との反応により、一般式(19)[Chemical 32] (In the formula, R 4 , X 1 and X 2 have the same meaning as in the general formula (11)) to obtain a compound, and then react with a suitable oxidizing agent such as hydrogen peroxide and a tertiary amine oxide. According to the general formula (19)

【化３３】 (式中、R4、X1及びX2は一般式(11)と同義を表す)で表さ
れる化合物を得る。一般式(19)の化合物は、一般式(2)
でX3が保護された水酸基を表す場合、一般式(6b)の化合
物等から、水酸基を脱保護し、得ることも可能である。
次いで、文献(a)記載の方法等により、一般式(7-8)[Chemical 33] (Wherein R 4 , X 1 and X 2 have the same meanings as in formula (11)) are obtained. The compound of the general formula (19) is represented by the general formula (2)
When X 3 represents a protected hydroxyl group, it can be obtained by deprotecting the hydroxyl group from the compound of the general formula (6b) or the like.
Then, by the method described in Document (a), the general formula (7-8)

【化３４】 (式中、R4、X1及びX2は一般式(11)と同義を表す)を得る
ことができる。[Chemical 34] (In the formula, R 4 , X 1 and X 2 have the same meanings as in the general formula (11)).

【００６４】あるいは、一般式(11)の化合物と二酸化炭
素から一般式(20)Alternatively, the compound of the general formula (20) is prepared from the compound of the general formula (11) and carbon dioxide.

【化３５】 (式中、R4、X1及びX2は一般式(11)と同義を表す)を得、
次いで文献(a)に記載の方法等により一般式(7-9)[Chemical 35] (In the formula, R 4 , X 1 and X 2 represent the same as in the general formula (11)),
Then the general formula (7-9) by the method described in literature (a)

【化３６】 (式中、R4、X1及びX2は一般式(11)と同義を表す)を得る
ことができる。一般式(7-9)の化合物は、一般式(2)でX3
がハロゲン原子を表す場合、一般式(6b)の化合物等か
ら、文献(a)に記載の方法等により得ることも可能であ
る。[Chemical 36] (In the formula, R 4 , X 1 and X 2 have the same meanings as in the general formula (11)). The compound of the general formula (7-9) is represented by the general formula (2) with X 3
When is a halogen atom, it can be obtained from the compound of the general formula (6b) or the like by the method described in the literature (a) or the like.

【００６５】あるいは、一般式(16)の化合物、あるいは
X3がハロゲン原子又はスルホニルオキシ基を表す一般式
(6b)の化合物、あるいは一般式(19)の化合物から文献
(a)に記載と類似の方法等で誘導されるトリフラート
と、一般式(21)Alternatively, a compound of the general formula (16), or
A general formula in which X 3 represents a halogen atom or a sulfonyloxy group.
From the compound of (6b) or the compound of general formula (19), reference
Triflate derived by a method similar to that described in (a), and the general formula (21)

【化３７】 (式中、t、C、D、T及びZは一般式(1)と同義を表す)と
の、パラジウム等の触媒存在下でのカップリング反応に
より一般式(7-10)[Chemical 37] (In the formula, t, C, D, T and Z represent the same meaning as in the general formula (1)), by the coupling reaction in the presence of a catalyst such as palladium, the general formula (7-10)

【化３８】 (式中、R4、X1及びX2は一般式(11)と同義を表し、t、
C、D、T及びZは一般式(1)と同義を表す)を得ることがで
きる。[Chemical 38] (In the formula, R 4 , X 1 and X 2 represent the same meaning as in the general formula (11), t,
C, D, T and Z have the same meaning as in the general formula (1).

【００６６】あるいは、一般式(20)の化合物と一般式(2
2)Alternatively, the compound of the general formula (20) and the general formula (2
2)

【化３９】 (式中、t、C、D、T及びZは一般式(1)と同義を表す)で表
される化合物との、カルボジイミド化合物等の縮合剤存
在下での反応により一般式(7-11)[Chemical Formula 39] (In the formula, t, C, D, T and Z represent the same meaning as in the general formula (1)), a compound represented by the general formula (7-11) by a reaction in the presence of a condensing agent such as a carbodiimide compound. )

【化４０】 (式中、R4、X1及びX2は一般式(11)と同義を表し、t、
C、D、T及びZは一般式(1)と同義を表す)で表される化合
物を得ることができる。[Chemical 40] (In the formula, R 4 , X 1 and X 2 represent the same meaning as in the general formula (11), t,
C, D, T and Z have the same meaning as in formula (1)), and thus a compound represented by the formula can be obtained.

【００６７】あるいは、一般式(19)の化合物と一般式(2
3)Alternatively, the compound of the general formula (19) and the general formula (2
3)

【化４１】 [Chemical 41]

【００６８】(式中、t、C、D、T及びZは一般式(1)と同
義を表す)で表される化合物との、カルボジイミド化合
物等の縮合剤存在下での反応により一般式(7-12)(Wherein, t, C, D, T and Z have the same meanings as in the general formula (1)) by the reaction in the presence of a condensing agent such as a carbodiimide compound, a general formula ( 7-12)

【化４２】 (式中、R4、X1及びX2は一般式(11)と同義を表し、t、
C、D、T及びZは一般式(1)と同義を表す)で表される化合
物を得ることができる。[Chemical 42] (In the formula, R 4 , X 1 and X 2 represent the same meaning as in the general formula (11), t,
C, D, T and Z have the same meaning as in formula (1)), and thus a compound represented by the formula can be obtained.

【００６９】更に、一般式(7-11)及び一般式(7-12)の化
合物から、特開平10-204016に記載の方法等により、一
般式(7-13)及び一般式(7-14)Further, from the compounds of the general formula (7-11) and the general formula (7-12), the general formula (7-13) and the general formula (7-14 )

【化４３】 (式中、R4、X1及びX2は一般式(11)と同義を表し、t、
C、D、T及びZは一般式(1)と同義を表す)で表される化合
物を、それぞれ、得ることができる。[Chemical 43] (In the formula, R 4 , X 1 and X 2 represent the same meaning as in the general formula (11), t,
C, D, T and Z have the same meanings as those in formula (1)), respectively.

【００７０】あるいは、一般式(11)の化合物とジメチル
ホルムアミドから一般式(24)Alternatively, the compound of the general formula (24) is prepared from the compound of the general formula (11) and dimethylformamide.

【００７１】[0071]

【化４４】 (式中、R4、X1及びX2は一般式(11)と同義を表す)を得、
次いで文献(a)に記載と類似の方法等により一般式(7-1
5)[Chemical 44] (In the formula, R 4 , X 1 and X 2 represent the same as in the general formula (11)),
Then, by a method similar to that described in literature (a), the general formula (7-1
Five)

【００７２】[0072]

【化４５】 (式中、R4、X1及びX2は一般式(11)と同義を表し、t、
C、D、T及びZは一般式(1)と同義を表す)で表される化合
物を得ることができる。[Chemical formula 45] (In the formula, R 4 , X 1 and X 2 represent the same meaning as in the general formula (11), t,
C, D, T and Z have the same meaning as in formula (1)), and thus a compound represented by the formula can be obtained.

【００７３】これらの製造方法は、目的とする化合物を
得るに際し、適時組替えたり順番を変えたりして用いる
ことも可能であり、従来公知の方法を追加して用いるこ
とも可能である。また、目的とする化合物を得るに際
し、各化合物中の官能基に応じて、適時、保護・脱保護
を用いることも可能である。These production methods can be used by appropriately rearranging them or changing the order when obtaining the desired compound, and conventionally known methods can be additionally used. Further, when obtaining the target compound, it is also possible to use protection / deprotection at appropriate times depending on the functional group in each compound.

【００７４】一般式(1)で表される化合物は高い比抵抗
や電圧保持率を得ることも容易であり、また他の液晶組
成物との相溶性に優れており、他の液晶化合物との混合
物の状態で液晶表示セル用材料として、好適に用いるこ
とができる。一般式(1)で表される化合物を2種以上用い
て、他の液晶化合物との混合物の状態で液晶表示セル用
材料として、好適に用いることも可能である。(1)の化
合物は前述の各種表示方式のいずれにおいても使用可能
であるが、単純マトリックス駆動あるいはアクティブマ
トリックス駆動のTN型表示素子、及びSTN表示素子に用
いることが適している。The compound represented by the general formula (1) is easy to obtain a high specific resistance and a high voltage holding ratio, and has excellent compatibility with other liquid crystal compositions, so that it is compatible with other liquid crystal compounds. It can be suitably used as a material for liquid crystal display cells in a mixture state. It is also possible to use two or more kinds of the compounds represented by the general formula (1) and suitably use them as a material for a liquid crystal display cell in the state of a mixture with other liquid crystal compounds. The compound of (1) can be used in any of the above-mentioned various display systems, but is suitable for use in a simple matrix drive or active matrix drive TN type display element and STN display element.

【００７５】本発明の提供する組成物においては、その
第一成分として一般式(1)で表される化合物を少なくと
も1種含有するが、その他の成分として特に以下の第二
〜第四成分から少なくとも1種含有することが好まし
い。The composition provided by the present invention contains at least one compound represented by the general formula (1) as the first component thereof, but as the other components, especially from the following second to fourth components: It is preferable to contain at least one kind.

【００７６】即ち、第二成分はいわゆるフッ素系(ハロ
ゲン系)のp型液晶化合物であって、以下の一般式(A1)〜
(A3)で示される化合物からなるものである。That is, the second component is a so-called fluorine-based (halogen-based) p-type liquid crystal compound, and has the following general formula (A1) to
It is composed of the compound represented by (A3).

【化４６】 [Chemical formula 46]

【００７７】上式中、Rbは炭素原子数1〜12のアルキル
基を表し、これらは直鎖状であってもメチル又はエチル
分岐を有していてもよく、3〜6員環の環状構造を有して
いてもよく、基内に存在する任意の-CH2-は-O-、-CH=CH
-、-CH=CF-、-CF=CH-、-CF=CF-又は-C≡C-により交換さ
れていてもよく、基内に存在する任意の水素原子はフッ
素原子又はトリフルオロメトキシ基により置換されてい
てもよいが、炭素原子数2〜7の直鎖状アルキル基、炭素
原子数2〜7の直鎖状1-アルケニル基、炭素原子数4〜7の
直鎖状3-アルケニル基、末端が炭素原子数1〜3のアルコ
キシル基により置換された炭素原子数1〜5のアルキル基
が好ましい。また、分岐により不斉炭素が生じる場合に
は、化合物として光学活性であってもラセミ体であって
もよい。In the above formula, R b represents an alkyl group having 1 to 12 carbon atoms, which may be linear or may have a methyl or ethyl branch and is a 3- to 6-membered cyclic group. Any --CH 2- , which may have a structure and is present in the group, is --O--, --CH = CH
-, -CH = CF-, -CF = CH-, -CF = CF- or -C≡C- may be exchanged, and any hydrogen atom present in the group is a fluorine atom or a trifluoromethoxy group. May be substituted by, but is a linear alkyl group having 2 to 7 carbon atoms, a linear 1-alkenyl group having 2 to 7 carbon atoms, a linear 3-alkenyl having 4 to 7 carbon atoms A group and an alkyl group having 1 to 5 carbon atoms whose terminal is substituted with an alkoxyl group having 1 to 3 carbon atoms are preferable. Further, when asymmetric carbon is generated by branching, the compound may be optically active or racemic.

【００７８】A、B及びCはそれぞれ独立的にトランス-1,
4-シクロヘキシレン基、トランスデカヒドロナフタレン
-トランス-2,6-ジイル基、1個以上のフッ素原子により
置換されていてもよい1,4-フェニレン基、1個以上のフ
ッ素原子により置換されていてもよいナフタレン-2,6-
ジイル基、1個以上のフッ素原子により置換されていて
もよいテトラヒドロナフタレン-2,6-ジイル基、フッ素
原子により置換されていてもよい1,4-シクロヘキセニレ
ン基、1,3-ジオキサン-トランス-2,5-ジイル基、ピリミ
ジン-2,5-ジイル基又はピリジン-2,5-ジイル基を表す
が、トランス-1,4-シクロヘキシレン基、トランスデカ
ヒドロナフタレン-トランス-2,6-ジイル基、フッ素原子
により置換されていてもよいナフタレン-2,6-ジイル基
又は1〜2個のフッ素原子により置換されていてもよい1,
4-フェニレン基が好ましい。特にBがトランス-1,4-シク
ロヘキシレン基又はトランスデカヒドロナフタレン-ト
ランス-2,6-ジイル基を表す場合に、Aはトランス-1,4-
シクロヘキシレン基を表すことが好ましく、Cがトラン
ス-1,4-シクロヘキシレン基又はトランスデカヒドロナ
フタレン-トランス-2,6-ジイル基を表す場合にB及びAは
トランス-1,4-シクロヘキシレン基を表すことが好まし
い。また、(A3)においてAはトランス-1,4-シクロヘキシ
レン基を表すことが好ましい。A, B and C are each independently trans-1,
4-cyclohexylene group, transdecahydronaphthalene
-Trans-2,6-diyl group, 1,4-phenylene group optionally substituted by one or more fluorine atoms, naphthalene-2,6-optionally substituted by one or more fluorine atoms
Diyl group, tetrahydronaphthalene-2,6-diyl group optionally substituted by one or more fluorine atoms, 1,4-cyclohexenylene group optionally substituted by fluorine atom, 1,3-dioxane- A trans-2,5-diyl group, a pyrimidine-2,5-diyl group or a pyridine-2,5-diyl group is represented, but a trans-1,4-cyclohexylene group, trans decahydronaphthalene-trans-2,6 -Diyl group, naphthalene optionally substituted by fluorine atom-2,6-diyl group or optionally substituted by 1 to 2 fluorine atoms 1,
A 4-phenylene group is preferred. Particularly when B represents a trans-1,4-cyclohexylene group or a transdecahydronaphthalene-trans-2,6-diyl group, A represents trans-1,4-
It is preferable to represent a cyclohexylene group, and when C represents a trans-1,4-cyclohexylene group or a transdecahydronaphthalene-trans-2,6-diyl group, B and A are trans-1,4-cyclohexylene. Preferably it represents a group. Further, in (A3), A preferably represents a trans-1,4-cyclohexylene group.

【００７９】La、Lb及びLcは連結基であって、それぞれ
独立的に単結合、エチレン基(-CH2CH2-)、1,2-プロピレ
ン基(-CH(CH3)CH2-及び-CH2CH(CH3)-)、1,4-ブチレン
基、-COO-、-OCO-、-OCF2-、-CF2O-、-CH=CH-、-CH=CF
-、-CF=CH-、-CF=CF-、-C≡C-又は-CH=NN=CH-を表す
が、単結合、エチレン基、1,4-ブチレン基、-COO-、-OC
F2-、-CF2O-、-CF=CF-又は-C≡C-が好ましく、単結合又
はエチレン基が特に好ましい。また、(A2)においてはそ
の少なくとも1個が、(A3)においてはその少なくとも2個
が単結合を表すことが好ましい。L a , L b and L c are linking groups, each independently being a single bond, an ethylene group (-CH 2 CH 2- ), a 1,2-propylene group (-CH (CH 3 ) CH 2 -and -CH 2 CH (CH 3 )-), 1,4-butylene group, -COO-, -OCO-, -OCF 2- , -CF 2 O-, -CH = CH-, -CH = CF
-, -CF = CH-, -CF = CF-, -C≡C- or -CH = NN = CH-, but a single bond, ethylene group, 1,4-butylene group, -COO-, -OC
F 2- , -CF 2 O-, -CF = CF- or -C≡C- is preferable, and a single bond or an ethylene group is particularly preferable. Further, it is preferable that at least one of them in (A2) and at least two of them in (A3) represent a single bond.

【００８０】環Zは芳香環を表し以下の一般式(IXa)〜(I
Xc)で表すことができる。Ring Z represents an aromatic ring and is represented by the following general formulas (IXa) to (I
Xc).

【化４７】 [Chemical 47]

【００８１】式中、Ya〜Yjはそれぞれ独立的に水素原子
あるいはフッ素原子を表すが、(IXa)において、Ya及びY
bの少なくとも1個はフッ素原子を表すことが好ましく、
(IXb)において、Yd〜Yfの少なくとも1個はフッ素原子を
表すことが好ましく、特にYdはフッ素原子を表すことが
さらに好ましい。[0081] In the formula, represents a Y a to Y j are each independently a hydrogen atom or fluorine atom, in (IXa), Y a and Y
At least one of b preferably represents a fluorine atom,
In (IXb), at least one of Y d to Y f preferably represents a fluorine atom, and particularly preferably Y d represents a fluorine atom.

【００８２】末端基Paはフッ素原子、塩素原子、トリフ
ルオロメトキシ基、ジフルオロメトキシ基、トリフルオ
ロメチル基又はジフルオロメチル基あるいは2個以上の
フッ素原子により置換された炭素原子数2又は3のアルコ
キシル基、アルキル基、アルケニル基又はアルケニルオ
キシ基を表すが、フッ素原子、トリフルオロメトキシ基
又はジフルオロメトキシ基が好ましく、フッ素原子が特
に好ましい。[0082] end group P a represents a fluorine atom, a chlorine atom, trifluoromethoxy group, difluoromethoxy group, trifluoromethyl group or difluoromethyl group or two or more alkoxyl carbon atoms 2 or 3 substituted by fluorine atoms It represents a group, an alkyl group, an alkenyl group or an alkenyloxy group, but a fluorine atom, a trifluoromethoxy group or a difluoromethoxy group is preferable, and a fluorine atom is particularly preferable.

【００８３】第三成分はいわゆるシアノ系のp型液晶化
合物であって、以下の一般式(B1)〜(B3)で示される化合
物からなるものである。The third component is a so-called cyano-based p-type liquid crystal compound, and is composed of compounds represented by the following general formulas (B1) to (B3).

【化４８】 [Chemical 48]

【００８４】上式中、Rcは炭素原子数1〜12のアルキル
基を表し、これらは直鎖状であってもメチル又はエチル
分岐を有していてもよく、3〜6員環の環状構造を有して
いてもよく、基内に存在する任意の-CH2-は-O-、-CH=CH
-、-CH=CF-、-CF=CH-、-CF=CF-又は-C≡C-により交換さ
れていてもよく、基内に存在する任意の水素原子はフッ
素原子又はトリフルオロメトキシ基により置換されてい
てもよいが、炭素原子数2〜7の直鎖状アルキル基、炭素
原子数2〜7の直鎖状1-アルケニル基、炭素原子数4〜7の
直鎖状3-アルケニル基、末端が炭素原子数1〜3のアルコ
キシル基により置換された炭素原子数1〜5のアルキル基
が好ましい。また、分岐により不斉炭素が生じる場合に
は、化合物として光学活性であってもラセミ体であって
もよい。In the above formula, R c represents an alkyl group having 1 to 12 carbon atoms, which may be linear or may have a methyl or ethyl branch and is a 3- to 6-membered cyclic group. Any --CH 2- , which may have a structure and is present in the group, is --O--, --CH = CH
-, -CH = CF-, -CF = CH-, -CF = CF- or -C≡C- may be exchanged, and any hydrogen atom present in the group is a fluorine atom or a trifluoromethoxy group. May be substituted by, but is a linear alkyl group having 2 to 7 carbon atoms, a linear 1-alkenyl group having 2 to 7 carbon atoms, a linear 3-alkenyl having 4 to 7 carbon atoms A group and an alkyl group having 1 to 5 carbon atoms whose terminal is substituted with an alkoxyl group having 1 to 3 carbon atoms are preferable. Further, when asymmetric carbon is generated by branching, the compound may be optically active or racemic.

【００８５】D、E及びFはそれぞれ独立的にトランス-1,
4-シクロヘキシレン基、トランスデカヒドロナフタレン
-トランス-2,6-ジイル基、1個以上のフッ素原子により
置換されていてもよい1,4-フェニレン基、1個以上のフ
ッ素原子により置換されていてもよいナフタレン-2,6-
ジイル基、1個以上のフッ素原子により置換されていて
もよいテトラヒドロナフタレン-2,6-ジイル基、フッ素
原子により置換されていてもよい1,4-シクロヘキセニレ
ン基、1,3-ジオキサン-トランス-2,5-ジイル基、ピリミ
ジン-2,5-ジイル基又はピリジン-2,5-ジイル基を表す
が、トランス-1,4-シクロヘキシレン基、トランスデカ
ヒドロナフタレン-トランス-2,6-ジイル基、フッ素原子
により置換されていてもよいナフタレン-2,6-ジイル基
又は1〜2個のフッ素原子により置換されていてもよい1,
4-フェニレン基が好ましい。特にEがトランス-1,4-シク
ロヘキシレン基又はトランスデカヒドロナフタレン-ト
ランス-2,6-ジイル基を表す場合に、Dはトランス-1,4-
シクロヘキシレン基を表すことが好ましく、Fがトラン
ス-1,4-シクロヘキシレン基又はトランスデカヒドロナ
フタレン-トランス-2,6-ジイル基を表す場合にD及びEは
トランス-1,4-シクロヘキシレン基を表すことが好まし
い。また、(B3)においてDはトランス-1,4-シクロヘキシ
レン基を表すことが好ましい。D, E and F are each independently trans-1,
4-cyclohexylene group, transdecahydronaphthalene
-Trans-2,6-diyl group, 1,4-phenylene group optionally substituted by one or more fluorine atoms, naphthalene-2,6-optionally substituted by one or more fluorine atoms
Diyl group, tetrahydronaphthalene-2,6-diyl group optionally substituted by one or more fluorine atoms, 1,4-cyclohexenylene group optionally substituted by fluorine atom, 1,3-dioxane- A trans-2,5-diyl group, a pyrimidine-2,5-diyl group or a pyridine-2,5-diyl group is represented, but a trans-1,4-cyclohexylene group, trans decahydronaphthalene-trans-2,6 -Diyl group, naphthalene optionally substituted by fluorine atom-2,6-diyl group or optionally substituted by 1 to 2 fluorine atoms 1,
A 4-phenylene group is preferred. Especially when E represents a trans-1,4-cyclohexylene group or a transdecahydronaphthalene-trans-2,6-diyl group, D represents trans-1,4-
It is preferable to represent a cyclohexylene group, and D and E are trans-1,4-cyclohexylene when F represents a trans-1,4-cyclohexylene group or a transdecahydronaphthalene-trans-2,6-diyl group. Preferably it represents a group. Further, in (B3), D preferably represents a trans-1,4-cyclohexylene group.

【００８６】Ld、Le及びLfは連結基であって、それぞれ
独立的に単結合、エチレン基(-CH2CH2-)、1,2-プロピレ
ン基(-CH(CH3)CH2-及び-CH2CH(CH3)-)、1,4-ブチレン
基、-COO-、-OCO-、-OCF2-、-CF2O-、-CH=CH-、-CH=CF
-、-CF=CH-、-CF=CF-、-C≡C-、-OCH2-、-CH2O-、又は-
CH=NN=CH-を表すが、単結合、エチレン基、-COO-、-OCF
2-、-CF2O-、-CF=CF-又は-C≡C-が好ましく、単結合、
エチレン基又は-COO-が特に好ましい。また、(B2)にお
いてはその少なくとも1個が、(B3)においてはその少な
くとも2個が単結合を表すことが好ましい。L d , L e and L f are linking groups, each independently a single bond, an ethylene group (-CH 2 CH 2- ), a 1,2-propylene group (-CH (CH 3 ) CH 2 -and -CH 2 CH (CH 3 )-), 1,4-butylene group, -COO-, -OCO-, -OCF 2- , -CF 2 O-, -CH = CH-, -CH = CF
-, -CF = CH-, -CF = CF-, -C≡C-, -OCH 2- , -CH 2 O-, or-
CH = NN = CH-, but single bond, ethylene group, -COO-, -OCF
2- , -CF 2 O-, -CF = CF- or -C≡C- is preferable, a single bond,
Particularly preferred is an ethylene group or -COO-. Further, it is preferable that at least one of them in (B2) and at least two of them in (B3) represent a single bond.

【００８７】環Yは芳香環を表し以下の一般式(IXd)〜(I
Xf)で表すことができる。Ring Y represents an aromatic ring and is represented by the following general formulas (IXd) to (I
Xf).

【化４９】 式中、Yk〜Yqはそれぞれ独立的に水素原子あるいはフッ
素原子を表すが、(IXe)において、Yn及びYoは水素原子
を表すことが好ましい。末端基Paはシアノ基(-CN)、シ
アナト基(-OCN)又は-C≡CCNを表すが、シアノ基が好ま
しい。[Chemical 49] In the formula, Y k to Y q each independently represent a hydrogen atom or a fluorine atom, but in (IXe), Y n and Y o preferably represent a hydrogen atom. The terminal group Pa represents a cyano group (-CN), a cyanato group (-OCN) or -C≡CCN, and a cyano group is preferable.

【００８８】第四成分は誘電率異方性が0程度である、
いわゆるn型液晶であり、以下の一般式(C1)〜(C3)で示
される化合物からなるものである。The fourth component has a dielectric anisotropy of about 0,
This is a so-called n-type liquid crystal, which is composed of compounds represented by the following general formulas (C1) to (C3).

【化５０】 [Chemical 50]

【００８９】上式中、Rd及びReはそれぞれ独立的に炭素
原子数1〜12のアルキル基を表し、これらは直鎖状であ
ってもメチル又はエチル分岐を有していてもよく、3〜6
員環の環状構造を有していてもよく、基内に存在する任
意の-CH2-は-O-、-CH=CH-、-CH=CF-、-CF=CH-、-CF=CF-
又は-C≡C-により交換されていてもよく、基内に存在す
る任意の水素原子はフッ素原子又はトリフルオロメトキ
シ基により置換されていてもよいが、炭素原子数1〜7の
直鎖状アルキル基、炭素原子数2〜7の直鎖状1-アルケニ
ル基、炭素原子数4〜7の直鎖状3-アルケニル基、炭素原
子数1〜3の直鎖状アルコキシル基又は末端が炭素原子数
1〜3アルコキシル基により置換された炭素原子数1〜5の
直鎖状アルキル基が好ましく、さらに少なくとも一方は
炭素原子数1〜7の直鎖状アルキル基、炭素原子数2〜7の
直鎖状1-アルケニル基又は炭素原子数4〜7の直鎖状3-ア
ルケニル基を表すことが特に好ましい。In the above formula, R d and R e each independently represent an alkyl group having 1 to 12 carbon atoms, which may be linear or may have a methyl or ethyl branch, 3 to 6
It may have a ring structure of a member ring, and any -CH 2- present in the group is -O-, -CH = CH-, -CH = CF-, -CF = CH-, -CF = CF-
Or, it may be replaced by -C≡C-, and any hydrogen atom present in the group may be substituted by a fluorine atom or a trifluoromethoxy group, but a straight chain having 1 to 7 carbon atoms Alkyl group, straight-chain 1-alkenyl group having 2 to 7 carbon atoms, straight-chain 3-alkenyl group having 4 to 7 carbon atoms, straight-chain alkoxyl group having 1 to 3 carbon atoms or the terminal is a carbon atom. number
A linear alkyl group having 1 to 5 carbon atoms substituted with 1 to 3 alkoxyl groups is preferable, and at least one is a linear alkyl group having 1 to 7 carbon atoms, and a linear chain having 2 to 7 carbon atoms. It is particularly preferred to represent a straight-chain 1-alkenyl group or a straight-chain 3-alkenyl group having 4 to 7 carbon atoms.

【００９０】G、H、I及びJはそれぞれ独立的に、トラン
ス-1,4-シクロヘキシレン基、トランスデカヒドロナフ
タレン-トランス-2,6-ジイル基、1〜2個のフッ素原子あ
るいはメチル基により置換されていてもよい1,4-フェニ
レン基、1個以上のフッ素原子により置換されていても
よいナフタレン-2,6-ジイル基、1〜2個のフッ素原子に
より置換されていてもよいテトラヒドロナフタレン-2,6
-ジイル基、1〜2個のフッ素原子により置換されていて
もよい1,4-シクロヘキセニレン基、1,3-ジオキサン-ト
ランス-2,5-ジイル基、ピリミジン-2,5-ジイル基又はピ
リジン-2,5-ジイル基を表すが、各化合物において、ト
ランスデカヒドロナフタレン-トランス-2,6-ジイル基、
1個以上のフッ素原子により置換されていてもよいナフ
タレン-2,6-ジイル基、1〜2個のフッ素原子により置換
されていてもよいテトラヒドロナフタレン-2,6-ジイル
基、フッ素原子により置換されていてもよい1,4-シクロ
ヘキセニレン基、1,3-ジオキサン-トランス-2,5-ジイル
基、ピリミジン-2,5-ジイル基又はピリジン-2,5-ジイル
基は1個以内であることが好ましく、他の環はトランス-
1,4-シクロヘキシレン基あるいは1〜2個のフッ素原子又
はメチル基により置換されていてもよい1,4-フェニレン
基を表すことが好ましい。G, H, I and J are each independently a trans-1,4-cyclohexylene group, transdecahydronaphthalene-trans-2,6-diyl group, 1 to 2 fluorine atoms or a methyl group. 1,4-phenylene group optionally substituted by, naphthalene-2,6-diyl group optionally substituted by one or more fluorine atoms, optionally substituted by 1 to 2 fluorine atoms Tetrahydronaphthalene-2,6
-Diyl group, 1,4-cyclohexenylene group optionally substituted by 1 to 2 fluorine atoms, 1,3-dioxane-trans-2,5-diyl group, pyrimidine-2,5-diyl group Or represents a pyridine-2,5-diyl group, in each compound, trans decahydronaphthalene-trans-2,6-diyl group,
Naphthalene-2,6-diyl group optionally substituted by one or more fluorine atoms, tetrahydronaphthalene-2,6-diyl group optionally substituted by 1-2 fluorine atoms, substituted by fluorine atom Up to 1 1,4-cyclohexenylene group, 1,3-dioxane-trans-2,5-diyl group, pyrimidine-2,5-diyl group or pyridine-2,5-diyl group And the other ring is trans-
It is preferable to represent a 1,4-cyclohexylene group or a 1,4-phenylene group which may be substituted with 1 to 2 fluorine atoms or a methyl group.

【００９１】Lg、Lh及びLiは連結基であって、それぞれ
独立的に単結合、エチレン基(-CH2CH2-)、1,2-プロピレ
ン基(-CH(CH3)CH2-及び-CH2CH(CH3)-)、1,4-ブチレン
基、-COO-、-OCO-、-OCF2-、-CF2O-、-CH=CH-、-CH=CF
-、-CF=CH-、-CF=CF-、-C≡C-又は-CH=NN=CH-を表す
が、単結合、エチレン基、1,4-ブチレン基、-COO-、-OC
O-、-OCF2-、-CF2O-、-CF=CF-、-C≡C-又は-CH=NN=CH-
が好ましく、(C2)においてはその少なくとも1個が、(C
3)においてはその少なくとも2個が単結合を表すことが
好ましい。L g , L h and L i are linking groups, each independently a single bond, an ethylene group (-CH 2 CH 2- ), a 1,2-propylene group (-CH (CH 3 ) CH 2 -and -CH 2 CH (CH 3 )-), 1,4-butylene group, -COO-, -OCO-, -OCF 2- , -CF 2 O-, -CH = CH-, -CH = CF
-, -CF = CH-, -CF = CF-, -C≡C- or -CH = NN = CH-, but a single bond, ethylene group, 1,4-butylene group, -COO-, -OC
O-, -OCF 2- , -CF 2 O-, -CF = CF-, -C≡C- or -CH = NN = CH-
Is preferred, and in (C2), at least one of them is (C
In 3), it is preferable that at least two of them represent a single bond.

【００９２】(C1)におけるより好ましい形態は以下の一
般式(C1a)〜(C1h)で表すことができる。A more preferable form of (C1) can be represented by the following general formulas (C1a) to (C1h).

【化５１】 [Chemical 51]

【００９３】上記各式中、Rf及びRgはそれぞれ独立的に
炭素原子数1〜7の直鎖状アルキル基、炭素原子数2〜7の
直鎖状1-アルケニル基、炭素原子数4〜7の直鎖状3-アル
ケニル基、炭素原子数1〜3の直鎖状アルコキシル基又は
末端が炭素原子数1〜3のアルコキシル基により置換され
た炭素原子数1〜5の直鎖状アルキル基を表すが、少なく
とも一方は炭素原子数1〜7の直鎖状アルキル基、炭素原
子数2〜7の直鎖状1-アルケニル基又は炭素原子数4〜7の
直鎖状3-アルケニル基を表す。ただし、G1〜G3が芳香環
の場合、対応するRfは1-アルケニル基及びアルコキシル
基を除き、H1〜H3が芳香環の場合、対応するRgは1-アル
ケニル基及びアルコキシル基を除く。In each of the above formulas, R f and R g are each independently a straight-chain alkyl group having 1 to 7 carbon atoms, a straight-chain 1-alkenyl group having 2 to 7 carbon atoms, and 4 carbon atoms. ~ 7 straight-chain 3-alkenyl group, straight-chain alkoxyl group having 1 to 3 carbon atoms or straight-chain alkyl having 1 to 5 carbon atoms substituted at the end with an alkoxyl group having 1 to 3 carbon atoms Represents a group, at least one of which is a linear alkyl group having 1 to 7 carbon atoms, a linear 1-alkenyl group having 2 to 7 carbon atoms or a linear 3-alkenyl group having 4 to 7 carbon atoms Represents However, when G1 to G3 are aromatic rings, the corresponding R f excludes 1-alkenyl groups and alkoxyl groups, and when H1 to H3 are aromatic rings, the corresponding R g excludes 1-alkenyl groups and alkoxyl groups.

【００９４】G1及びH1はそれぞれ独立的にトランス-1,4
-シクロヘキシレン基、トランスデカヒドロナフタレン-
トランス-2,6-ジイル基、1〜2個のフッ素原子あるいは
メチル基により置換されていてもよい1,4-フェニレン
基、1個以上のフッ素原子により置換されていてもよい
ナフタレン-2,6-ジイル基、1〜2個のフッ素原子により
置換されていてもよいテトラヒドロナフタレン-2,6-ジ
イル基、1〜2個のフッ素原子により置換されていてもよ
い1,4-シクロヘキセニレン基、1,3-ジオキサン-トラン
ス-2,5-ジイル基、ピリミジン-2,5-ジイル基又はピリジ
ン-2,5-ジイル基を表すが、各化合物において、トラン
スデカヒドロナフタレン-トランス-2,6-ジイル基、1個
以上のフッ素原子により置換されていてもよいナフタレ
ン-2,6-ジイル基、1〜2個のフッ素原子により置換され
ていてもよいテトラヒドロナフタレン-2,6-ジイル基、
フッ素原子により置換されていてもよい1,4-シクロヘキ
セニレン基、1,3-ジオキサン-トランス-2,5-ジイル基、
ピリミジン-2,5-ジイル基又はピリジン-2,5-ジイル基は
1個以内であることが好ましく、その場合の他方の環は
トランス-1,4-シクロヘキシレン基あるいは1〜2個のフ
ッ素原子又はメチル基により置換されていてもよい1,4-
フェニレン基を表す。G2及びH2はそれぞれ独立的にトラ
ンス-1,4-シクロヘキシレン基、トランスデカヒドロナ
フタレン-トランス-2,6-ジイル基、1〜2個のフッ素原子
あるいはメチル基により置換されていてもよい1,4-フェ
ニレン基、1個以上のフッ素原子により置換されていて
もよいナフタレン-2,6-ジイル基、1〜2個のフッ素原子
により置換されていてもよいテトラヒドロナフタレン-
2,6-ジイル基を表すが、各化合物において、トランスデ
カヒドロナフタレン-トランス-2,6-ジイル基、1個以上
のフッ素原子により置換されていてもよいナフタレン-
2,6-ジイル基、1〜2個のフッ素原子により置換されてい
てもよいテトラヒドロナフタレン-2,6-ジイル基は1個以
内を表すことが好ましく、その場合の他方の環はトラン
ス-1,4-シクロヘキシレン基あるいは1〜2個のフッ素原
子又はメチル基により置換されていてもよい1,4-フェニ
レン基を表す。G3及びH3はそれぞれ独立的に1〜2個のフ
ッ素原子あるいはメチル基により置換されていてもよい
1,4-フェニレン基、1個以上のフッ素原子により置換さ
れていてもよいナフタレン-2,6-ジイル基、1〜2個のフ
ッ素原子により置換されていてもよいテトラヒドロナフ
タレン-2,6-ジイル基を表すが、各化合物において1個以
上のフッ素原子により置換されていてもよいナフタレン
-2,6-ジイル基、1〜2個のフッ素原子により置換されて
いてもよいテトラヒドロナフタレン-2,6-ジイル基は1個
以内であることが好ましい。G1 and H1 are independently trans-1,4
-Cyclohexylene group, transdecahydronaphthalene-
Trans-2,6-diyl group, 1,4-phenylene group optionally substituted by 1 to 2 fluorine atoms or methyl group, naphthalene-2 optionally substituted by one or more fluorine atoms, 6-diyl group, tetrahydronaphthalene which may be substituted by 1 to 2 fluorine atoms-2,6-diyl group, 1,4-cyclohexenylene which may be substituted by 1 to 2 fluorine atoms Group, 1,3-dioxane-trans-2,5-diyl group, pyrimidine-2,5-diyl group or pyridine-2,5-diyl group, in each compound, transdecahydronaphthalene-trans-2 , 6-diyl group, naphthalene-2,6-diyl group optionally substituted by one or more fluorine atoms, tetrahydronaphthalene-2,6-diyl optionally substituted by 1-2 fluorine atoms Base,
1,4-cyclohexenylene group optionally substituted by a fluorine atom, 1,3-dioxane-trans-2,5-diyl group,
Pyrimidine-2,5-diyl group or pyridine-2,5-diyl group is
It is preferably within 1 and the other ring in that case is trans-1,4-cyclohexylene group or 1,4-which may be substituted with 1 to 2 fluorine atoms or a methyl group.
Represents a phenylene group. G2 and H2 each independently may be substituted with a trans-1,4-cyclohexylene group, transdecahydronaphthalene-trans-2,6-diyl group, 1 to 2 fluorine atoms or a methyl group. , 4-phenylene group, naphthalene optionally substituted by one or more fluorine atoms-2,6-diyl group, tetrahydronaphthalene optionally substituted by 1-2 fluorine atoms-
Represents a 2,6-diyl group, in each compound trans decahydronaphthalene-trans-2,6-diyl group, naphthalene optionally substituted by one or more fluorine atoms-
2,6-diyl group, tetrahydronaphthalene which may be substituted by 1 to 2 fluorine atoms-2,6-diyl group preferably represents one or less, in which case the other ring is trans-1 It represents a 1,4-cyclohexylene group or a 1,4-phenylene group optionally substituted by 1 to 2 fluorine atoms or a methyl group. G3 and H3 may each independently be substituted with 1 to 2 fluorine atoms or a methyl group.
1,4-phenylene group, naphthalene-2,6-diyl group optionally substituted by one or more fluorine atoms, tetrahydronaphthalene-2,6-optionally substituted by 1 to 2 fluorine atoms Represents a diyl group, naphthalene optionally substituted by one or more fluorine atoms in each compound
The number of -2,6-diyl group and tetrahydronaphthalene-2,6-diyl group which may be substituted by 1 to 2 fluorine atoms is preferably 1 or less.

【００９５】(C2)におけるより好ましい形態は以下の一
般式(C2a)〜(C2m)で表すことができる。A more preferable form of (C2) can be represented by the following general formulas (C2a) to (C2m).

【化５２】 [Chemical 52]

【００９６】上式中、G1、G2、G3、H1、H2及びH3は前述
の意味を表し、I1はG1と、I2はG2と、I3はG3とそれぞれ
おなじ意味を表す。また、上記各化合物において、トラ
ンスデカヒドロナフタレン-トランス-2,6-ジイル基、1
個以上のフッ素原子により置換されていてもよいナフタ
レン-2,6-ジイル基、1〜2個のフッ素原子により置換さ
れていてもよいテトラヒドロナフタレン-2,6-ジイル
基、フッ素原子により置換されていてもよい1,4-シクロ
ヘキセニレン基、1,3-ジオキサン-トランス-2,5-ジイル
基、ピリミジン-2,5-ジイル基又はピリジン-2,5-ジイル
基は1個以内であることが好ましく、その場合の他方の
環はトランス-1,4-シクロヘキシレン基あるいは1〜2個
のフッ素原子又はメチル基により置換されていてもよい
1,4-フェニレン基を表す。In the above formula, G1, G2, G3, H1, H2 and H3 have the same meanings as described above, I1 has the same meaning as G1, I2 has the same meaning as G2 and I3 has the same meaning as G3. In each of the above compounds, a trans decahydronaphthalene-trans-2,6-diyl group, 1
Naphthalene-2,6-diyl group optionally substituted by one or more fluorine atoms, tetrahydronaphthalene-2,6-diyl group optionally substituted by 1-2 fluorine atoms, substituted by a fluorine atom 1,4-cyclohexenylene group, 1,3-dioxane-trans-2,5-diyl group, pyrimidine-2,5-diyl group or pyridine-2,5-diyl group may be 1 or less. Preferably, the other ring in that case may be substituted by a trans-1,4-cyclohexylene group or 1 to 2 fluorine atoms or a methyl group.
Represents a 1,4-phenylene group.

【００９７】次に(C3)におけるより好ましい形態は以下
の一般式(C3a)〜(C3f)で表すことができる。Next, a more preferable form of (C3) can be represented by the following general formulas (C3a) to (C3f).

【化５３】 [Chemical 53]

【００９８】上式中、G1、G2、H1、H2、I1及びI2は前述
の意味を表し、J1はG1またJ2はG2とそれぞれおなじ意味
を表す。また、上記各化合物において、トランスデカヒ
ドロナフタレン-トランス-2,6-ジイル基、1個以上のフ
ッ素原子により置換されていてもよいナフタレン-2,6-
ジイル基、1〜2個のフッ素原子により置換されていても
よいテトラヒドロナフタレン-2,6-ジイル基、フッ素原
子により置換されていてもよい1,4-シクロヘキセニレン
基、1,3-ジオキサン-トランス-2,5-ジイル基、ピリミジ
ン-2,5-ジイル基又はピリジン-2,5-ジイル基は1個以内
であることが好ましく、その場合の他方の環はトランス
-1,4-シクロヘキシレン基あるいは1〜2個のフッ素原子
又はメチル基により置換されていてもよい1,4-フェニレ
ン基を表す。In the above formula, G1, G2, H1, H2, I1 and I2 have the same meanings as described above, J1 has the same meaning as G1 and J2 has the same meaning as G2. In each of the above compounds, transdecahydronaphthalene-trans-2,6-diyl group, naphthalene-2,6-which may be substituted with one or more fluorine atoms.
Diyl group, tetrahydronaphthalene-2,6-diyl group optionally substituted by 1 to 2 fluorine atoms, 1,4-cyclohexenylene group optionally substituted by fluorine atom, 1,3-dioxane -Trans-2,5-diyl group, pyrimidine-2,5-diyl group or pyridine-2,5-diyl group is preferably 1 or less, in which case the other ring is trans
-1,4-cyclohexylene group or a 1,4-phenylene group optionally substituted by 1 to 2 fluorine atoms or a methyl group.

【００９９】後述する実施例からも明らかなように、本
発明の化合物は、レスポンスに優れ、高速表示液晶ディ
スプレイ用の液晶材料として好適である。本発明の液晶
組成物についても同様であり、本発明の表示素子は高速
に応答するという優れた特性を発揮する。また、本発明
の化合物は、優れた液晶性、及び現在汎用の液晶化合
物、液晶組成物への優れた相溶性を有している。また、
液晶相を示す温度範囲が広く、閾値電圧が低く、高速応
答が可能な液晶組成物を調製するうえにおいて従来の化
合物より優れた効果を有していることがわかる。閾値電
圧の低減効果が大きく、低電圧駆動可能な液晶材料とし
ても極めて優れている。As will be apparent from the examples described below, the compound of the present invention has excellent response and is suitable as a liquid crystal material for a high speed display liquid crystal display. The same applies to the liquid crystal composition of the present invention, and the display element of the present invention exhibits an excellent property of responding at high speed. Further, the compound of the present invention has excellent liquid crystallinity and excellent compatibility with liquid crystal compounds and liquid crystal compositions which are currently widely used. Also,
It can be seen that it has a superior effect to the conventional compound in preparing a liquid crystal composition having a wide temperature range showing a liquid crystal phase, a low threshold voltage and capable of high speed response. It has a large effect of reducing the threshold voltage and is extremely excellent as a liquid crystal material that can be driven at a low voltage.

【０１００】従って、一般式(1)の化合物は、他のネマ
チック液晶化合物との混合物の状態で、TN型あるいはST
N型等の電界効果型表示セル用として、特に温度範囲が
広く低電圧駆動が可能な液晶材料として好適に使用する
ことができる。また(1)の化合物のなかで分子内に強い
極性基を持たないものは、大きい比抵抗と高い電圧保持
率を得ることが容易であり、アクティブマトリックス駆
動用液晶材料の構成成分として使用することも可能であ
る。本発明はこのように一般式(1)で表される化合物、
及び、少なくともその1種類をその構成成分として含有
する液晶組成物をも提供するものである。Therefore, the compound of the general formula (1) can be mixed with other nematic liquid crystal compounds in a TN type or ST type.
It can be suitably used as a liquid crystal material having a wide temperature range and capable of being driven at a low voltage particularly for N-type field effect display cells. In addition, among the compounds of (1), those that do not have a strong polar group in the molecule can easily obtain a large specific resistance and a high voltage holding ratio, and should be used as a constituent component of a liquid crystal material for active matrix driving. Is also possible. The present invention is thus a compound represented by the general formula (1),
And a liquid crystal composition containing at least one of them as a constituent.

【０１０１】[0101]

【実施例】以下、実施例を挙げて本発明を更に詳述する
が、本発明はこれらの実施例に限定されるものではな
い。The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.

【０１０２】(実施例1) 5,7-ジフルオロ-2-プロピル-
1,4-ジヒドロナフタレンの合成Example 1 5,7-Difluoro-2-propyl-
Synthesis of 1,4-dihydronaphthalene

【化５４】 (1-a) 5,7-ジフルオロ-1,2,3,4-テトラヒドロナフタレ
ン-2-オンの合成 5,7-ジフルオロフェニル酢酸200g及び塩化チオニル300g
の1,2-ジクロロエタン400mL溶液中に、触媒量のピリジ
ンを加え窒素雰囲気5時間加熱還流した後、1,2-ジクロ
ロエタン及び過剰の塩化チオニルを溜去した。得られた
残渣を、-20℃の冷却下、ジクロロメタン1000mL、塩化
アルミニウム320gに滴下する。30分の攪拌の後、エチレ
ンガスを吹き入れ、さらに5時間攪拌した後、稀塩酸を
加え、有機層を分離した後、水層はトルエンで抽出し
た。有機層を併せ、水、飽和重曹水、水、飽和食塩水で
順次洗浄後、無水硫酸ナトリウムで脱水乾燥させ、溶媒
を溜去し、減圧蒸留を行った後、ヘキサンから再結晶さ
せ5,7-ジフルオロ-1,2,3,4-テトラヒドロナフタレン-2-
オンの170gを得た。[Chemical 54] (1-a) Synthesis of 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-one 5,7-difluorophenylacetic acid 200 g and thionyl chloride 300 g
A catalytic amount of pyridine was added to 400 mL of a solution of 1,2-dichloroethane in 1, and the mixture was heated under reflux for 5 hours in a nitrogen atmosphere, and 1,2-dichloroethane and excess thionyl chloride were distilled off. The obtained residue is added dropwise to 1000 mL of dichloromethane and 320 g of aluminum chloride under cooling at -20 ° C. After stirring for 30 minutes, ethylene gas was blown thereinto, the mixture was further stirred for 5 hours, diluted hydrochloric acid was added, the organic layer was separated, and then the aqueous layer was extracted with toluene. The organic layers were combined, washed successively with water, saturated aqueous sodium hydrogen carbonate, water and saturated brine, dried over anhydrous sodium sulfate, evaporated to remove the solvent, and distilled under reduced pressure, followed by recrystallization from hexane 5,7. -Difluoro-1,2,3,4-tetrahydronaphthalene-2-
Got 170g on.

【０１０３】(1-b)5,7-ジフルオロ-2-プロピル-1,4-ジ
ヒドロナフタレンの合成 テトラヒドロフラン(THF)50mLに(1-a)で得た5,7-ジフル
オロ-1,2,3,4-テトラヒドロナフタレン-2-オン10.0gを
溶解させ、次いで亜鉛末5.4gを加え、攪拌下、懸濁させ
る。室温下、トリメチルシリルクロリド0.3mLを加えた
後、アリルブロミド10.0gを30分かけて滴下し(このとき
系内温度は50℃に達していた)、更に1時間攪拌した。10
％塩酸20mLを加えた後、トルエンで抽出し、水、飽和食
塩水の順に洗浄し、無水硫酸マグネシウムで乾燥した。
次いで、溶媒を溜去して12.3gの5,7-ジフルオロ-2-(2-
プロぺニル)-1,2,3,4-テトラヒドロナフタレン-2-オー
ル粗生成物を得た。(1-b) Synthesis of 5,7-difluoro-2-propyl-1,4-dihydronaphthalene 5,7-difluoro-1,2, obtained in (1-a) in 50 mL of tetrahydrofuran (THF) Dissolve 10.0 g of 3,4-tetrahydronaphthalen-2-one, then add 5.4 g of zinc dust and suspend with stirring. After adding 0.3 mL of trimethylsilyl chloride at room temperature, 10.0 g of allyl bromide was added dropwise over 30 minutes (at this time, the system temperature had reached 50 ° C.), and the mixture was further stirred for 1 hour. Ten
After adding 20 %% hydrochloric acid, the mixture was extracted with toluene, washed with water and saturated brine in that order, and dried over anhydrous magnesium sulfate.
Then, the solvent was distilled off and 12.3 g of 5,7-difluoro-2- (2-
A crude product of propenyl) -1,2,3,4-tetrahydronaphthalen-2-ol was obtained.

【０１０４】この粗生成物を酢酸エチル48mLに溶解し、
5％パラジウムカーボン0.6gとともに0.5MPaの水素雰囲
気下、2時間攪拌した後、濾過、濃縮し5,7-ジフルオロ-
2-プロピル-1,2,3,4-テトラヒドロナフタレン-2-オール
の粗生成物12gを得た。この粗生成物をトルエン50mL
中、p-トルエンスルホン酸一水和物0.6gとともに2時間
加熱還流した後、室温へ冷却し、水、飽和食塩水の順に
洗浄、無水硫酸マグネシウムで乾燥、濃縮し、5,7-ジフ
ルオロ-2-プロピル-3,4-ジヒドロナフタレン及び5,7-ジ
フルオロ-2-プロピル-1,4-ジヒドロナフタレンの混合物
を得た。次いで、減圧蒸留、カラムクロマトグラフィー
で精製し、5,7-ジフルオロ-2-プロピル-1,4-ジヒドロナ
フタレン3.2gを得た。このものは室温で液体であった。The crude product was dissolved in 48 mL of ethyl acetate,
After stirring for 2 hours under a hydrogen atmosphere of 0.5 MPa with 0.6 g of 5% palladium carbon, the mixture was filtered and concentrated to give 5,7-difluoro-
12 g of a crude product of 2-propyl-1,2,3,4-tetrahydronaphthalen-2-ol was obtained. 50 mL of this crude product in toluene
After heating under reflux with 0.6 g of p-toluenesulfonic acid monohydrate for 2 hours, the mixture was cooled to room temperature, washed with water and saturated brine in that order, dried over anhydrous magnesium sulfate, and concentrated to give 5,7-difluoro- A mixture of 2-propyl-3,4-dihydronaphthalene and 5,7-difluoro-2-propyl-1,4-dihydronaphthalene was obtained. Then, it was purified by distillation under reduced pressure and column chromatography to obtain 3.2 g of 5,7-difluoro-2-propyl-1,4-dihydronaphthalene. It was a liquid at room temperature.

【０１０５】同様にして以下の化合物を得た。 6-フルオロ-2-プロピル-1,4-ジヒドロナフタレン 5,7-ジクロロ-2-プロピル-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-プロピル-
1,4-ジヒドロナフタレン 5,7-ジクロロ-6-トリフルオロメトキシ-2-プロピル-1,4
-ジヒドロナフタレン 6-トリフルオロメトキシ-2-プロピル-1,4-ジヒドロナフ
タレンSimilarly, the following compounds were obtained. 6-fluoro-2-propyl-1,4-dihydronaphthalene 5,7-dichloro-2-propyl-1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2-propyl-
1,4-dihydronaphthalene 5,7-dichloro-6-trifluoromethoxy-2-propyl-1,4
-Dihydronaphthalene 6-trifluoromethoxy-2-propyl-1,4-dihydronaphthalene

【０１０６】(実施例2) 2-プロピル-6-ヨード-5,7-ジ
フルオロ-1,4-ジヒドロナフタレンの合成Example 2 Synthesis of 2-propyl-6-iodo-5,7-difluoro-1,4-dihydronaphthalene

【化５５】 実施例1で得た5,7-ジフルオロ-2-プロピル-1,4-ジヒド
ロナフタレン10.0gをTHF50mLに溶解し、-50℃に冷却
下、n-ブチルリチウム1.51Mヘキサン溶液32mLを滴下
し、5,7-ジフルオロ-6-リチオ-2-プロピル-1,4-ジヒド
ロナフタレンを調製した。次いで、THF42mLに溶解した
ヨウ素13.4gを滴下し、2時間攪拌後、水20mLを加え反応
を停止させた。室温へ戻した後、有機層を亜硫酸水素ナ
トリウム水溶液、飽和食塩水の順で洗浄し、無水硫酸マ
グネシウムで乾燥した。溶媒を溜去し、カラムクロマト
グラフィーで精製し、2-プロピル-6-ヨード-5,7-ジフル
オロ-1,4-ジヒドロナフタレン16gを得た。[Chemical 55] 5,7-difluoro-2-propyl-1,4-dihydronaphthalene 10.0g obtained in Example 1 was dissolved in THF 50mL, under cooling to -50 ℃, n- butyllithium 1.51M hexane solution 32mL was added dropwise. 5,7-Difluoro-6-lithio-2-propyl-1,4-dihydronaphthalene was prepared. Next, 13.4 g of iodine dissolved in 42 mL of THF was added dropwise, and after stirring for 2 hours, 20 mL of water was added to stop the reaction. After returning to room temperature, the organic layer was washed with an aqueous sodium hydrogen sulfite solution and saturated brine in that order, and dried over anhydrous magnesium sulfate. The solvent was distilled off and the residue was purified by column chromatography to obtain 16 g of 2-propyl-6-iodo-5,7-difluoro-1,4-dihydronaphthalene.

【０１０７】(実施例3) 5,7-ジフルオロ-2-プロピル-6
-(3,4,5-トリフルオロフェニル)-1,4-ジヒドロナフタレ
ンの合成Example 3 5,7-Difluoro-2-propyl-6
Synthesis of-(3,4,5-trifluorophenyl) -1,4-dihydronaphthalene

【化５６】 3,4,5-トリフルオロブロモベンゼンとマグネシウムから
調製したグリニャール反応剤とホウ酸トリメチルとの反
応から得られる3,4,5-トリフルオロフェニルホウ酸6.3g
と、実施例2で得た2-プロピル-6-ヨード-5,7-ジフルオ
ロ-1,4-ジヒドロナフタレン10gを、テトラキス(トリフ
ェニルホスフィノ)パラジウム(0)0.86g存在下、トルエ
ン40mL、2M炭酸カリウム水溶液40mL中で10時間還流し、室温
へ戻した後、有機層を水、飽和食塩水の順で洗浄し、無
水硫酸マグネシウムで乾燥した。溶媒を溜去し、カラム
クロマトグラフィーで精製し、エタノールから再結晶さ
せ2-プロピル-6-(3,4,5-トリフルオロフェニル)-5,7-ジ
フルオロ-1,4-ジヒドロナフタレン5.0gを得た。[Chemical 56] 6.3 g of 3,4,5-trifluorophenyl borate obtained from the reaction of trimethyl borate with a Grignard reagent prepared from 3,4,5-trifluorobromobenzene and magnesium
With 2-propyl-6-iodo-5,7-difluoro-1,4-dihydronaphthalene 10 g obtained in Example 2, tetrakis (triphenylphosphino) palladium (0) 0.86 g in the presence of toluene 40 mL, After refluxing for 10 hours in 40 mL of 2M aqueous potassium carbonate solution and returning to room temperature, the organic layer was washed with water and saturated brine in that order, and dried over anhydrous magnesium sulfate. The solvent was distilled off, the residue was purified by column chromatography, and recrystallized from ethanol to give 2-propyl-6- (3,4,5-trifluorophenyl) -5,7-difluoro-1,4-dihydronaphthalene 5.0 g Got

【０１０８】同様にして以下の化合物を得た。 5,7-ジフルオロ-2-プロピル-6-(4-フルオロフェニル)-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-プロピル-6-(3,4-ジフルオロフェニ
ル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-プロピル-6-{4-(トリフルオロメトキ
シ)フェニル}-3,4,-ジヒドロナフタレン 5,7-ジフルオロ-2-プロピル-6-{4-(トリフルオロメトキ
シ)-3-フルオロフェニル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-プロピル-6-{4-(トリフルオロメトキ
シ)-3,5-ジフルオロフェニル}-1,4-ジヒドロナフタレンSimilarly, the following compounds were obtained. 5,7-Difluoro-2-propyl-6- (4-fluorophenyl)-
1,4-dihydronaphthalene 5,7-difluoro-2-propyl-6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2-propyl-6- {4- (tri (Fluoromethoxy) phenyl} -3,4, -dihydronaphthalene 5,7-difluoro-2-propyl-6- {4- (trifluoromethoxy) -3-fluorophenyl} -1,4-dihydronaphthalene 5,7- Difluoro-2-propyl-6- {4- (trifluoromethoxy) -3,5-difluorophenyl} -1,4-dihydronaphthalene

【０１０９】(実施例4) 2-プロピル-6-｛2-(3,4,5-ト
リフルオロフェニル)エチニル｝-5,7-ジフルオロ-1,4-
ジヒドロナフタレンの合成Example 4 2-Propyl-6- {2- (3,4,5-trifluorophenyl) ethynyl} -5,7-difluoro-1,4-
Synthesis of dihydronaphthalene

【化５７】 実施例2で得た2-プロピル-6-ヨード-5,7-ジフルオロ-1,
4-ジヒドロナフタレン10gと(3,4,5-トリフルオロフェニ
ル)アセチレン5.5gとをジメチルホルムアミド(DMF)60mL
及びトリエチルアミン20mL中、ヨウ化銅0.11g及びテト
ラキス(トリフェニルホスフィノ)パラジウム(0)0.69gの
存在下に、90℃で8時間攪拌し、室温へ戻した後、水に
加え、ヘキサンで抽出した。有機層を水、飽和食塩水の
順で洗浄し、無水硫酸マグネシウムで乾燥した。溶媒を
溜去し、カラムクロマトグラフィーで精製し、エタノー
ルから再結晶させ2-プロピル-6-｛2-(3,4,5-トリフルオ
ロフェニル)エチニル｝-5,7-ジフルオロ-1,4-ジヒドロ
ナフタレン7.0gを得た。[Chemical 57] 2-Propyl-6-iodo-5,7-difluoro-1, obtained in Example 2,
4-dihydronaphthalene 10 g and (3,4,5-trifluorophenyl) acetylene 5.5 g dimethylformamide (DMF) 60 mL
In 20 mL of triethylamine, in the presence of 0.11 g of copper iodide and 0.69 g of tetrakis (triphenylphosphino) palladium (0), the mixture was stirred at 90 ° C for 8 hours, returned to room temperature, added to water, and extracted with hexane. did. The organic layer was washed with water and saturated brine in that order, and dried over anhydrous magnesium sulfate. The solvent was distilled off, the residue was purified by column chromatography, and recrystallized from ethanol to give 2-propyl-6- {2- (3,4,5-trifluorophenyl) ethynyl} -5,7-difluoro-1,4. -7.0 g of dihydronaphthalene was obtained.

【０１１０】同様にして以下の化合物を得た。 2-プロピル-6-｛2-(4-フルオロフェニル)エチニル｝-5,
7-ジフルオロ-1,4-ジヒドロナフタレン 2-プロピル-6-｛2-(3,4-ジフルオロフェニル)エチニ
ル｝-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-プロピル-6-｛2-{4-(トリフルオロメトキシ)フェニ
ル}エチニル｝-5,7-ジフルオロ-1,4-ジヒドロナフタレ
ン 2-プロピル-6-｛2-{4-(トリフルオロメトキシ)-3-フル
オロフェニル}エチニル｝-5,7-ジフルオロ-1,4-ジヒド
ロナフタレン 2-プロピル-6-｛2-{4-(トリフルオロメトキシ)-3,5-ジ
フルオロフェニル}エチニル｝-5,7-ジフルオロ-1,4-ジ
ヒドロナフタレンSimilarly, the following compounds were obtained. 2-propyl-6- {2- (4-fluorophenyl) ethynyl} -5,
7-Difluoro-1,4-dihydronaphthalene 2-propyl-6- {2- (3,4-difluorophenyl) ethynyl} -5,7-difluoro-1,4-dihydronaphthalene 2-propyl-6- {2 -{4- (Trifluoromethoxy) phenyl} ethynyl} -5,7-difluoro-1,4-dihydronaphthalene 2-propyl-6- {2- {4- (trifluoromethoxy) -3-fluorophenyl} ethynyl } -5,7-Difluoro-1,4-dihydronaphthalene 2-propyl-6- {2- {4- (trifluoromethoxy) -3,5-difluorophenyl} ethynyl} -5,7-difluoro-1, 4-dihydronaphthalene

【０１１１】(実施例5) 2-プロピル-5,7-ジフルオロ-
1,4-ジヒドロナフタレン-6-カルボン酸3,4,5-トリフル
オロフェニルの合成Example 5 2-Propyl-5,7-difluoro-
Synthesis of 3,4,5-trifluorophenyl 1,4-dihydronaphthalene-6-carboxylic acid

【化５８】 実施例2で調製した5,7-ジフルオロ-6-リチオ-2-プロピ
ル-1,4-ジヒドロナフタレンより、二酸化炭素(ドライア
イス)との反応により5,7-ジフルオロ-6-カルボキシル-2
-プロピル-1,4-ジヒドロナフタレンを得た。次いで、そ
の5.0gと3,4,5-トリフルオロフェノール2.9gと1-(3-ジ
メチルアミノプロピル)-3-エチルカルボジイミド塩酸塩
4.2gとを塩化メチレン30mL中で室温下8時間攪拌後、有
機層を飽和食塩水で洗浄し、無水硫酸マグネシウムで乾
燥した。溶媒を溜去し、カラムクロマトグラフィーで精
製し、エタノールから再結晶させ2-プロピル-5,7-ジフ
ルオロ-1,4-ジヒドロナフタレン-6-カルボン酸 3,4,5-
トリフルオロフェニル5.1gを得た。[Chemical 58] From 5,7-difluoro-6-lithio-2-propyl-1,4-dihydronaphthalene prepared in Example 2, 5,7-difluoro-6-carboxyl-2 by reaction with carbon dioxide (dry ice)
-Propyl-1,4-dihydronaphthalene was obtained. Then, 5.0 g and 3,4,5-trifluorophenol 2.9 g and 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride
After stirring 4.2 g and 30 mL of methylene chloride at room temperature for 8 hours, the organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was distilled off, the residue was purified by column chromatography, and recrystallized from ethanol to give 2-propyl-5,7-difluoro-1,4-dihydronaphthalene-6-carboxylic acid 3,4,5-
5.1 g of trifluorophenyl was obtained.

【０１１２】同様にして以下の化合物を得た。 2-プロピル-5,7-ジフルオロ-1,4-ジヒドロナフタレン-6
-カルボン酸 4-フルオロフェニル 2-プロピル-5,7-ジフルオロ-1,4-ジヒドロナフタレン-6
-カルボン酸 3,4-ジフルオロフェニル 2-プロピル-5,7-ジフルオロ-1,4-ジヒドロナフタレン-6
-カルボン酸 4-トリフルオロメトキシフェニル 2-プロピル-5,7-ジフルオロ-1,4-ジヒドロナフタレン-6
-カルボン酸 3-フルオロ-4-トリフルオロメトキシフェ
ニル 2-プロピル-5,7-ジフルオロ-1,4-ジヒドロナフタレン-6
-カルボン酸 3,5-ジフルオロ-4-トリフルオロメトキシ
フェニル 2-プロピル-5,7-ジフルオロ-1,4-ジヒドロナフタレン-6
-カルボン酸 4-シアノフェニル 2-プロピル-5,7-ジフルオロ-1,4-ジヒドロナフタレン-6
-カルボン酸 3-フルオロ-4-シアノフェニル 2-プロピル-5,7-ジフルオロ-1,4-ジヒドロナフタレン-6
-カルボン酸 3,5-ジフルオロ-4-シアノフェニルSimilarly, the following compounds were obtained. 2-propyl-5,7-difluoro-1,4-dihydronaphthalene-6
-Carboxylic acid 4-fluorophenyl 2-propyl-5,7-difluoro-1,4-dihydronaphthalene-6
-Carboxylic acid 3,4-difluorophenyl 2-propyl-5,7-difluoro-1,4-dihydronaphthalene-6
-Carboxylic acid 4-trifluoromethoxyphenyl 2-propyl-5,7-difluoro-1,4-dihydronaphthalene-6
-Carboxylic acid 3-fluoro-4-trifluoromethoxyphenyl 2-propyl-5,7-difluoro-1,4-dihydronaphthalene-6
-Carboxylic acid 3,5-difluoro-4-trifluoromethoxyphenyl 2-propyl-5,7-difluoro-1,4-dihydronaphthalene-6
-Carboxylic acid 4-cyanophenyl 2-propyl-5,7-difluoro-1,4-dihydronaphthalene-6
-Carboxylic acid 3-fluoro-4-cyanophenyl 2-propyl-5,7-difluoro-1,4-dihydronaphthalene-6
-Carboxylic acid 3,5-difluoro-4-cyanophenyl

【０１１３】(実施例6)2-プロピル-6-(トランス-4-プロ
ピルシクロヘキシル)-5,7-ジフルオロ-1,4-ジヒドロナ
フタレンの合成Example 6 Synthesis of 2-propyl-6- (trans-4-propylcyclohexyl) -5,7-difluoro-1,4-dihydronaphthalene

【化５９】 削り状マグネシウム0.87gへ、実施例2で得た2-プロピル
-6-ヨード-5,7-ジフルオロ-1,4-ジヒドロナフタレン10g
をTHF40mLへ溶解し、還流するような速度で滴下し、グ
リニャール反応剤を調製した。室温へ戻し、4-プロピル
シクロヘキサノン4.3gをTHF16mLに溶解し、滴下した。1
0%塩酸を加え、トルエン抽出し、有機層を合わせ、水、
飽和食塩水の順に洗浄し、無水硫酸マグネシウムで乾燥
した。溶媒を溜去し、2-プロピル-6-(4-プロピル-1-ヒ
ドロキシシクロヘキシル)-5,7-ジフルオロ-1,4-ジヒド
ロナフタレンの粗生成物10.5gを得た。これを塩化メチ
レン50mLに溶解し、ピリジン2.4gを加え、氷冷下にメタ
ンスルホン酸クロリド3.5gを滴下する。1時間攪拌の
後、水を加え、有機層を分離し、水、飽和食塩水の順に
洗浄し、無水硫酸マグネシウムで乾燥した。溶媒を溜去
し、粗生成物を得た。これをTHF50mLに溶解し、リチウ
ムアルミニウムハイドライド1.2gのTHF30mL懸濁液に滴
下した。氷冷下、10%塩酸を加え、トルエン抽出し、有
機層を合わせ、水、飽和食塩水の順に洗浄し、無水硫酸
マグネシウムで乾燥した。溶媒を溜去し、粗生成物を得
た。これをDMF50mLに溶解し、t-ブトキシカリウム2.0g
を加え90℃で6時間攪拌した。水にあけ、ヘキサン抽出
し、有機層を合わせ、水、飽和食塩水の順に洗浄し、無
水硫酸マグネシウムで乾燥した。溶媒を溜去し、10.0g
の粗生成物を得た。カラムクロマトグラフィーの後、エ
タノールより再結晶させ、2-プロピル-6-(トランス-4-
プロピルシクロヘキシル)-5,7-ジフルオロ-1,4-ジヒド
ロナフタレン4.9gを得た。[Chemical 59] To 0.87 g of scraped magnesium, the 2-propyl obtained in Example 2 was added.
-6-iodo-5,7-difluoro-1,4-dihydronaphthalene 10g
Was dissolved in 40 mL of THF and added dropwise at a rate such that it was refluxed to prepare a Grignard reaction agent. After returning to room temperature, 4.3 g of 4-propylcyclohexanone was dissolved in 16 mL of THF and added dropwise. 1
0% hydrochloric acid was added, extracted with toluene, the organic layers were combined, water,
The extract was washed successively with saturated brine and dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain 10.5 g of a crude product of 2-propyl-6- (4-propyl-1-hydroxycyclohexyl) -5,7-difluoro-1,4-dihydronaphthalene. This is dissolved in 50 mL of methylene chloride, 2.4 g of pyridine is added, and 3.5 g of methanesulfonic acid chloride is added dropwise under ice cooling. After stirring for 1 hour, water was added, the organic layer was separated, washed with water and saturated brine in that order, and dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain a crude product. This was dissolved in 50 mL of THF and added dropwise to a suspension of 1.2 g of lithium aluminum hydride in 30 mL of THF. Under ice-cooling, 10% hydrochloric acid was added, extracted with toluene, the organic layers were combined, washed with water and saturated brine in that order, and dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain a crude product. Dissolve this in DMF 50mL, t-butoxy potassium 2.0g
Was added and stirred at 90 ° C. for 6 hours. The mixture was poured into water, extracted with hexane, the organic layers were combined, washed with water and saturated brine in that order, and dried over anhydrous magnesium sulfate. The solvent was distilled off, 10.0 g
The crude product of was obtained. After column chromatography, recrystallize from ethanol to give 2-propyl-6- (trans-4-
Propylcyclohexyl) -5,7-difluoro-1,4-dihydronaphthalene (4.9 g) was obtained.

【０１１４】同様にして以下の化合物を得た。 2-プロピル-6-(トランス-4-ブチルシクロヘキシル)-5,7
-ジフルオロ-1,4-ジヒドロナフタレン 2-プロピル-6-(トランス-4-ペンチルシクロヘキシル)-
5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-プロピル-6-(トランス-4-ビニルシクロヘキシル)-5,7
-ジフルオロ-1,4-ジヒドロナフタレン 2-プロピル-6-{トランス-4-(3-ブテニル)シクロヘキシ
ル}-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-プロピル-6-{トランス-4-(3-ペンテニル)シクロヘキ
シル}-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-プロピル-6-(トランス,トランス-4'-プロピルビシク
ロヘキシル)-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-プロピル-6-(トランス,トランス-4'-ブチルビシクロ
ヘキシル)-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-プロピル-6-(トランス,トランス-4'-ペンチルビシク
ロヘキシル)-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-プロピル-6-(トランス,トランス-4'-ビニルビシクロ
ヘキシル)-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-プロピル-6-{トランス,トランス-4'-(3-ブテニル)ビ
シクロヘキシル}-5,7-ジフルオロ-1,4-ジヒドロナフタ
レン 2-プロピル-6-{トランス,トランス-4'-(3-ペンテニル)
ビシクロヘキシル}-5,7-ジフルオロ-1,4-ジヒドロナフ
タレンSimilarly, the following compounds were obtained. 2-Propyl-6- (trans-4-butylcyclohexyl) -5,7
-Difluoro-1,4-dihydronaphthalene 2-propyl-6- (trans-4-pentylcyclohexyl)-
5,7-Difluoro-1,4-dihydronaphthalene 2-propyl-6- (trans-4-vinylcyclohexyl) -5,7
-Difluoro-1,4-dihydronaphthalene 2-propyl-6- {trans-4- (3-butenyl) cyclohexyl} -5,7-difluoro-1,4-dihydronaphthalene 2-propyl-6- {trans-4 -(3-Pentenyl) cyclohexyl} -5,7-difluoro-1,4-dihydronaphthalene 2-propyl-6- (trans, trans-4'-propylbicyclohexyl) -5,7-difluoro-1,4- Dihydronaphthalene 2-propyl-6- (trans, trans-4'-butylbicyclohexyl) -5,7-difluoro-1,4-dihydronaphthalene 2-propyl-6- (trans, trans-4'-pentylbicyclohexyl ) -5,7-Difluoro-1,4-dihydronaphthalene 2-propyl-6- (trans, trans-4'-vinylbicyclohexyl) -5,7-difluoro-1,4-dihydronaphthalene 2-propyl-6 -{Trans, trans-4 '-(3-butenyl) bicyclohexyl} -5,7-difluoro-1,4-dihydronaphthalene 2-propyl-6- {tra Scan, trans-4 '- (3-pentenyl)
Bicyclohexyl} -5,7-difluoro-1,4-dihydronaphthalene

【０１１５】(実施例7) 5,7-ジフルオロ-2-ペンチル-1,
4-ジヒドロナフタレンの合成Example 7 5,7-Difluoro-2-pentyl-1,
Synthesis of 4-dihydronaphthalene

【化６０】 トルエン60mLと1-ペンチン15.0gの混合物にメチルマグ
ネシウムブロミドの1.4M THF／トルエン(25／75)溶液6
9.0mLを加え、2.5時間環流した後、25℃まで冷却した。
ここへ、実施例1で得た5,7-ジフルオロ-1,2,3,4-テトラ
ヒドロナフタレン-2-オンの8.0gをトルエン24mLに溶解
し、10分かけて滴下した。更に1時間の攪拌し、10％塩
酸60mLを加えた後、トルエンで抽出し、水、飽和食塩水
の順に洗浄し、無水硫酸マグネシウムで乾燥した。次い
で、溶媒を溜去して11gの5,7-ジフルオロ-2-(1-ペンチ
ニル)-1,2,3,4-テトラヒドロナフタレン-2-オール粗生
成物を得た。次いで、実施例1と同様にして、5,7-ジフ
ルオロ-2-ペンチル-1,4-ジヒドロナフタレン10gを得
た。[Chemical 60] 1.4M THF / toluene (25/75) solution of methylmagnesium bromide in a mixture of 60 mL of toluene and 15.0 g of 1-pentyne 6
After adding 9.0 mL and refluxing for 2.5 hours, the mixture was cooled to 25 ° C.
8.0 g of 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-one obtained in Example 1 was dissolved in 24 mL of toluene, and the solution was added dropwise over 10 minutes. The mixture was further stirred for 1 hour, added with 60 mL of 10% hydrochloric acid, extracted with toluene, washed with water and saturated brine in this order, and dried over anhydrous magnesium sulfate. Then, the solvent was distilled off to obtain 11 g of 5,7-difluoro-2- (1-pentynyl) -1,2,3,4-tetrahydronaphthalen-2-ol crude product. Then, in the same manner as in Example 1, 10 g of 5,7-difluoro-2-pentyl-1,4-dihydronaphthalene was obtained.

【０１１６】同様にして以下の化合物を得た。 5,7-ジフルオロ-2-ブチル-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-ヘキシル-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-ヘプチル-1,4-ジヒドロナフタレン 5,7-ジクロロ-2-ブチル-1,4-ジヒドロナフタレン 5,7-ジクロロ-2-ペンチル-1,4-ジヒドロナフタレン 5,7-ジクロロ-2-ヘキシル-1,4-ジヒドロナフタレン 5,7-ジクロロ-2-ヘプチル-1,4-ジヒドロナフタレン 6-フルオロ-2-ブチル-1,4-ジヒドロナフタレン 6-フルオロ-2-ペンチル-1,4-ジヒドロナフタレン 6-フルオロ-2-ヘキシル-1,4-ジヒドロナフタレン 6-フルオロ-2-ヘプチル-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-ブチル-1,4-ジヒドロナフタ
レン 6-トリフルオロメトキシ-2-ペンチル-1,4-ジヒドロナフ
タレン 6-トリフルオロメトキシ-2-ヘキシル-1,4-ジヒドロナフ
タレン 6-トリフルオロメトキシ-2-ヘプチル-1,4-ジヒドロナフ
タレン 3,4,5-トリフルオロ-2-ブチル-1,4-ジヒドロナフタレン 3,4,5-トリフルオロ-2-ペンチル-1,4-ジヒドロナフタレ
ン 3,4,5-トリフルオロ-2-ヘキシル-1,4-ジヒドロナフタレ
ン 3,4,5-トリフルオロ-2-ヘプチル-1,4-ジヒドロナフタレ
ンSimilarly, the following compound was obtained. 5,7-difluoro-2-butyl-1,4-dihydronaphthalene 5,7-difluoro-2-hexyl-1,4-dihydronaphthalene 5,7-difluoro-2-heptyl-1,4-dihydronaphthalene 5, 7-dichloro-2-butyl-1,4-dihydronaphthalene 5,7-dichloro-2-pentyl-1,4-dihydronaphthalene 5,7-dichloro-2-hexyl-1,4-dihydronaphthalene 5,7- Dichloro-2-heptyl-1,4-dihydronaphthalene 6-fluoro-2-butyl-1,4-dihydronaphthalene 6-fluoro-2-pentyl-1,4-dihydronaphthalene 6-fluoro-2-hexyl-1, 4-dihydronaphthalene 6-fluoro-2-heptyl-1,4-dihydronaphthalene 6-trifluoromethoxy-2-butyl-1,4-dihydronaphthalene 6-trifluoromethoxy-2-pentyl-1,4-dihydronaphthalene 6-trifluoromethoxy-2-hexyl-1,4-dihydronaphthalene 6-trifluoromethoxy-2-heptyl-1,4-dihydronaphthalene 3, 4,5-trifluoro-2-butyl-1,4-dihydronaphthalene 3,4,5-trifluoro-2-pentyl-1,4-dihydronaphthalene 3,4,5-trifluoro-2-hexyl-1 , 4-Dihydronaphthalene 3,4,5-trifluoro-2-heptyl-1,4-dihydronaphthalene

【０１１７】(実施例8) 2-ペンチル-6-(3,4,5-トリフル
オロフェニル)-5,7-ジフルオロ-1,4-ジヒドロナフタレ
ンの合成 実施例7で得た、5,7-ジフルオロ-2-ペンチル-1,4-ジヒ
ドロナフタレンより、実施例3と同様にして2-ペンチル-
6-(3,4,5-トリフルオロフェニル)-5,7-ジフルオロ-1,4-
ジヒドロナフタレンを得た。Example 8 Synthesis of 2-Pentyl-6- (3,4,5-trifluorophenyl) -5,7-difluoro-1,4-dihydronaphthalene 5,7, obtained in Example 7 -Difluoro-2-pentyl-1,4-dihydronaphthalene, 2-pentyl-in the same manner as in Example 3.
6- (3,4,5-trifluorophenyl) -5,7-difluoro-1,4-
Dihydronaphthalene was obtained.

【０１１８】同様にして以下の化合物を得た。 2-ブチル-6-(3,4,5-トリフルオロフェニル)-5,7-ジフル
オロ-1,4-ジヒドロナフタレン 2-ヘキシル-6-(3,4,5-トリフルオロフェニル)-5,7-ジフ
ルオロ-1,4-ジヒドロナフタレン 2-ヘプチル-6-(3,4,5-トリフルオロフェニル)-5,7-ジフ
ルオロ-1,4-ジヒドロナフタレン 2-ブチル-6-(4-フルオロフェニル)-5,7-ジフルオロ-1,4
-ジヒドロナフタレン 2-ペンチル-6-(4-フルオロフェニル)-5,7-ジフルオロ-
1,4-ジヒドロナフタレン 2-ヘキシル-6-(4-フルオロフェニル)-5,7-ジフルオロ-
1,4-ジヒドロナフタレン 2-ヘプチル-6-(4-フルオロフェニル)-5,7-ジフルオロ-
1,4-ジヒドロナフタレン 2-ブチル-6-(4,5-ジフルオロフェニル)-5,7-ジフルオロ
-1,4-ジヒドロナフタレン 2-ペンチル-6-(4,5-ジフルオロフェニル)-5,7-ジフルオ
ロ-1,4-ジヒドロナフタレン 2-ヘキシル-6-(4,5-ジフルオロフェニル)-5,7-ジフルオ
ロ-1,4-ジヒドロナフタレン 2-ヘプチル-6-(4,5-ジフルオロフェニル)-5,7-ジフルオ
ロ-1,4-ジヒドロナフタレン 2-ブチル-6-(4-トリフルオロメトキシフェニル)-5,7-ジ
フルオロ-1,4-ジヒドロナフタレン 2-ペンチル-6-(4-トリフルオロメトキシフェニル)-5,7-
ジフルオロ-1,4-ジヒドロナフタレン 2-ヘキシル-6-(4-トリフルオロメトキシフェニル)-5,7-
ジフルオロ-1,4-ジヒドロナフタレン 2-ヘプチル-6-(4-トリフルオロメトキシフェニル)-5,7-
ジフルオロ-1,4-ジヒドロナフタレン 2-ブチル-6-(4-トリフルオロメトキシ-3-フルオロフェ
ニル)-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-ペンチル-6-(4-トリフルオロメトキシ-3-フルオロフ
ェニル)-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-ヘキシル-6-(4-トリフルオロメトキシ-3-フルオロフ
ェニル)-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-ヘプチル-6-(4-トリフルオロメトキシ-3-フルオロフ
ェニル)-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-ブチル-6-(4-トリフルオロメトキシ-3,5-ジフルオロ
フェニル)-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-ペンチル-6-(4-トリフルオロメトキシ-3,5-ジフルオ
ロフェニル)-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-ヘキシル-6-(4-トリフルオロメトキシ-3,5-ジフルオ
ロフェニル)-5,7-ジフルオロ-1,4-ジヒドロナフタレン 2-ヘプチル-6-(4-トリフルオロメトキシ-3,5-ジフルオ
ロフェニル)-5,7-ジフルオロ-1,4-ジヒドロナフタレンThe following compounds were obtained in the same manner. 2-Butyl-6- (3,4,5-trifluorophenyl) -5,7-difluoro-1,4-dihydronaphthalene 2-hexyl-6- (3,4,5-trifluorophenyl) -5, 7-Difluoro-1,4-dihydronaphthalene 2-heptyl-6- (3,4,5-trifluorophenyl) -5,7-difluoro-1,4-dihydronaphthalene 2-butyl-6- (4-fluoro Phenyl) -5,7-difluoro-1,4
-Dihydronaphthalene 2-pentyl-6- (4-fluorophenyl) -5,7-difluoro-
1,4-dihydronaphthalene 2-hexyl-6- (4-fluorophenyl) -5,7-difluoro-
1,4-dihydronaphthalene 2-heptyl-6- (4-fluorophenyl) -5,7-difluoro-
1,4-dihydronaphthalene 2-butyl-6- (4,5-difluorophenyl) -5,7-difluoro
-1,4-dihydronaphthalene 2-pentyl-6- (4,5-difluorophenyl) -5,7-difluoro-1,4-dihydronaphthalene 2-hexyl-6- (4,5-difluorophenyl) -5 , 7-Difluoro-1,4-dihydronaphthalene 2-heptyl-6- (4,5-difluorophenyl) -5,7-difluoro-1,4-dihydronaphthalene 2-butyl-6- (4-trifluoromethoxy Phenyl) -5,7-difluoro-1,4-dihydronaphthalene 2-pentyl-6- (4-trifluoromethoxyphenyl) -5,7-
Difluoro-1,4-dihydronaphthalene 2-hexyl-6- (4-trifluoromethoxyphenyl) -5,7-
Difluoro-1,4-dihydronaphthalene 2-heptyl-6- (4-trifluoromethoxyphenyl) -5,7-
Difluoro-1,4-dihydronaphthalene 2-butyl-6- (4-trifluoromethoxy-3-fluorophenyl) -5,7-difluoro-1,4-dihydronaphthalene 2-pentyl-6- (4-trifluoro Methoxy-3-fluorophenyl) -5,7-difluoro-1,4-dihydronaphthalene 2-hexyl-6- (4-trifluoromethoxy-3-fluorophenyl) -5,7-difluoro-1,4-dihydro Naphthalene 2-heptyl-6- (4-trifluoromethoxy-3-fluorophenyl) -5,7-difluoro-1,4-dihydronaphthalene 2-butyl-6- (4-trifluoromethoxy-3,5-difluoro Phenyl) -5,7-difluoro-1,4-dihydronaphthalene 2-pentyl-6- (4-trifluoromethoxy-3,5-difluorophenyl) -5,7-difluoro-1,4-dihydronaphthalene 2- Hexyl-6- (4-trifluoromethoxy-3,5-difluorophenyl) -5,7-difluoro-1,4-dihydronaphthalene 2-heptyl-6- (4-trifluoro Rometokishi 3,5-difluorophenyl) -5,7-difluoro-1,4-dihydronaphthalene

【０１１９】(実施例9)5,7-ジフルオロ-2-{2-(トランス
-4-プロピルシクロヘキシル)エチル}-1,4-ジヒドロナフ
タレンの合成(Example 9) 5,7-difluoro-2- {2- (trans
Of (-4-propylcyclohexyl) ethyl} -1,4-dihydronaphthalene

【化６１】 実施例1で得た5,7-ジフルオロ-1,2,3,4-テトラヒドロナ
フタレン-2-オンと(トランス-4-プロピルシクロヘキシ
ル)アセチレンとから、実施例7と同様にして5,7-ジフル
オロ-2-{2-(トランス-4-プロピルシクロヘキシル)エチ
ル}-1,4-ジヒドロナフタレンを得た。[Chemical formula 61] From 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-one and (trans-4-propylcyclohexyl) acetylene obtained in Example 1, 5,7-in the same manner as in Example 7. Difluoro-2- {2- (trans-4-propylcyclohexyl) ethyl} -1,4-dihydronaphthalene was obtained.

【０１２０】同様にして以下の化合物を得た。 5,7-ジフルオロ-2-{2-(トランス-4-エチルシクロヘキシ
ル)エチル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ブチルシクロヘキシ
ル)エチル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ペンチルシクロヘキ
シル)エチル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ヘプチルシクロヘキ
シル)エチル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{2-(トランス-4-エチルシクロヘキシル)
エチル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{2-(トランス-4-プロピルシクロヘキシ
ル)エチル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{2-(トランス-4-ブチルシクロヘキシル)
エチル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{2-(トランス-4-ペンチルシクロヘキシ
ル)エチル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{2-(トランス-4-ヘプチルシクロヘキシ
ル)エチル}-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-{2-(トランス-4-エチルシク
ロヘキシル)エチル}-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-{2-(トランス-4-プロピルシ
クロヘキシル)エチル}-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-{2-(トランス-4-ブチルシク
ロヘキシル)エチル}-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-{2-(トランス-4-ペンチルシ
クロヘキシル)エチル}-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-{2-(トランス-4-ヘプチルシ
クロヘキシル)エチル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{2-(トラン
ス-4-エチルシクロヘキシル)エチル}-1,4-ジヒドロナフ
タレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{2-(トラン
ス-4-プロピルシクロヘキシル)エチル}-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{2-(トラン
ス-4-ブチルシクロヘキシル)エチル}-1,4-ジヒドロナフ
タレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{2-(トラン
ス-4-ペンチルシクロヘキシル)エチル}-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{2-(トラン
ス-4-ヘプチルシクロヘキシル)エチル}-1,4-ジヒドロナ
フタレン 5,6,7-トリフルオロ-2-{2-(トランス-4-エチルシクロヘ
キシル)エチル}-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-{2-(トランス-4-ブチルシクロヘ
キシル)エチル}-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-{2-(トランス-4-ペンチルシクロ
ヘキシル)エチル}-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-{2-(トランス-4-ヘプチルシクロ
ヘキシル)エチル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-エチルビ
シクロヘキシル)エチル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-プロピル
ビシクロヘキシル)エチル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ブチルビ
シクロヘキシル)エチル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ペンチル
ビシクロヘキシル)エチル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ヘプチル
ビシクロヘキシル)エチル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{2-(トランス,トランス-4'-エチルビシク
ロヘキシル)エチル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{2-(トランス,トランス-4'-プロピルビシ
クロヘキシル)エチル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{2-(トランス,トランス-4'-ブチルビシク
ロヘキシル)エチル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{2-(トランス,トランス-4'-ペンチルビシ
クロヘキシル)エチル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{2-(トランス,トランス-4'-ヘプチルビシ
クロヘキシル)エチル}-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-{2-(トランス,トランス-4'-
エチルビシクロヘキシル)エチル}-1,4-ジヒドロナフタ
レン 6-トリフルオロメトキシ-2-{2-(トランス,トランス-4'-
プロピルビシクロヘキシル)エチル}-1,4-ジヒドロナフ
タレン 6-トリフルオロメトキシ-2-{2-(トランス,トランス-4'-
ブチルビシクロヘキシル)エチル}-1,4-ジヒドロナフタ
レン 6-トリフルオロメトキシ-2-{2-(トランス,トランス-4'-
ペンチルビシクロヘキシル)エチル}-1,4-ジヒドロナフ
タレン 6-トリフルオロメトキシ-2-{2-(トランス,トランス-4'-
ヘプチルビシクロヘキシル)エチル}-1,4-ジヒドロナフ
タレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{2-(トラン
ス,トランス-4'-エチルビシクロヘキシル)エチル}-1,4-
ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{2-(トラン
ス,トランス-4'-プロピルビシクロヘキシル)エチル}-1,
4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{2-(トラン
ス,トランス-4'-ブチルビシクロヘキシル)エチル}-1,4-
ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{2-(トラン
ス,トランス-4'-ペンチルビシクロヘキシル)エチル}-1,
4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{2-(トラン
ス,トランス-4'-ヘプチルビシクロヘキシル)エチル}-1,
4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-{2-(トランス,トランス-4'-エチ
ルビシクロヘキシル)エチル}-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-{2-(トランス,トランス-4'-プロ
ピルビシクロヘキシル)エチル}-1,4-ジヒドロナフタレ
ン 5,6,7-トリフルオロ-2-{2-(トランス,トランス-4'-ブチ
ルビシクロヘキシル)エチル}-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-{2-(トランス,トランス-4'-ペン
チルビシクロヘキシル)エチル}-1,4-ジヒドロナフタレ
ン 5,6,7-トリフルオロ-2-{2-(トランス,トランス-4'-ヘプ
チルビシクロヘキシル)エチル}-1,4-ジヒドロナフタレ
ンSimilarly, the following compounds were obtained. 5,7-Difluoro-2- {2- (trans-4-ethylcyclohexyl) ethyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-butylcyclohexyl) ethyl}- 1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-pentylcyclohexyl) ethyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4- Heptylcyclohexyl) ethyl} -1,4-dihydronaphthalene 6-fluoro-2- {2- (trans-4-ethylcyclohexyl)
Ethyl} -1,4-dihydronaphthalene 6-fluoro-2- {2- (trans-4-propylcyclohexyl) ethyl} -1,4-dihydronaphthalene 6-fluoro-2- {2- (trans-4-butyl Cyclohexyl)
Ethyl} -1,4-dihydronaphthalene 6-fluoro-2- {2- (trans-4-pentylcyclohexyl) ethyl} -1,4-dihydronaphthalene 6-fluoro-2- {2- (trans-4-heptyl Cyclohexyl) ethyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {2- (trans-4-ethylcyclohexyl) ethyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {2- (Trans-4-propylcyclohexyl) ethyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {2- (trans-4-butylcyclohexyl) ethyl} -1,4-dihydronaphthalene 6-trifluoromethoxy -2- {2- (trans-4-pentylcyclohexyl) ethyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {2- (trans-4-heptylcyclohexyl) ethyl} -1,4-dihydro Naphthalene 5,7-difluoro-6-trifluoromethoxy-2- {2- (trans-4-ethylcyclo) Hexyl) ethyl} -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {2- (trans-4-propylcyclohexyl) ethyl} -1,4-dihydronaphthalene 5,7-difluoro -6-trifluoromethoxy-2- {2- (trans-4-butylcyclohexyl) ethyl} -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {2- (trans-4 -Pentylcyclohexyl) ethyl} -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {2- (trans-4-heptylcyclohexyl) ethyl} -1,4-dihydronaphthalene 5,6 , 7-Trifluoro-2- {2- (trans-4-ethylcyclohexyl) ethyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2- {2- (trans-4-butylcyclohexyl) Ethyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2- {2- (trans-4-pentylcyclohexyl) ethyl} -1,4-dihydro Phthalene 5,6,7-trifluoro-2- {2- (trans-4-heptylcyclohexyl) ethyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4 ' -Ethylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-propylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 5,7- Difluoro-2- {2- (trans, trans-4'-butylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-pentylbicyclohexyl) ) Ethyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-heptylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 6-fluoro-2- {2 -(Trans, trans-4'-ethylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 6-fluoro-2- {2- (trans, trans-4'-propylbicyclo Hexyl) ethyl} -1,4-dihydronaphthalene 6-fluoro-2- {2- (trans, trans-4'-butylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 6-fluoro-2- {2- (Trans, trans-4'-pentylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 6-fluoro-2- {2- (trans, trans-4'-heptylbicyclohexyl) ethyl} -1,4-dihydro Naphthalene 6-trifluoromethoxy-2- {2- (trans, trans-4'-
Ethylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {2- (trans, trans-4'-
Propylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {2- (trans, trans-4'-
Butylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {2- (trans, trans-4'-
Pentylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {2- (trans, trans-4'-
Heptylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {2- (trans, trans-4'-ethylbicyclohexyl) ethyl} -1,4-
Dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {2- (trans, trans-4'-propylbicyclohexyl) ethyl} -1,
4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {2- (trans, trans-4'-butylbicyclohexyl) ethyl} -1,4-
Dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {2- (trans, trans-4'-pentylbicyclohexyl) ethyl} -1,
4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {2- (trans, trans-4'-heptylbicyclohexyl) ethyl} -1,
4-dihydronaphthalene 5,6,7-trifluoro-2- {2- (trans, trans-4'-ethylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2- {2- (trans, trans-4'-propylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2- {2- (trans, trans-4'-butylbicyclohexyl) Ethyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2- {2- (trans, trans-4'-pentylbicyclohexyl) ethyl} -1,4-dihydronaphthalene 5,6,7- Trifluoro-2- {2- (trans, trans-4'-heptylbicyclohexyl) ethyl} -1,4-dihydronaphthalene

【０１２１】(実施例10) 5,7-ジフルオロ-2-{2-(トラン
ス-4-プロピルシクロヘキシル)エチル}-6-(3,4,5-トリ
フルオロフェニル)-1,4-ジヒドロナフタレンの合成Example 10 5,7-Difluoro-2- {2- (trans-4-propylcyclohexyl) ethyl} -6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene Synthesis of

【化６２】 実施例9で得た5,7-ジフルオロ-2-{2-(トランス-4-プロ
ピルシクロヘキシル)エチル}-1,4-ジヒドロナフタレン
から、実施例3と同様にして、5,7-ジフルオロ-2-{2-(ト
ランス-4-プロピルシクロヘキシル)エチル}-6-(3,4,5-
トリフルオロフェニル)-1,4-ジヒドロナフタレンを得
た。[Chemical formula 62] 5,7-Difluoro-2- {2- (trans-4-propylcyclohexyl) ethyl} -1,4-dihydronaphthalene obtained in Example 9 was used in the same manner as in Example 3 to give 5,7-difluoro- 2- {2- (trans-4-propylcyclohexyl) ethyl} -6- (3,4,5-
Trifluorophenyl) -1,4-dihydronaphthalene was obtained.

【０１２２】同様にして以下の化合物を得た。 5,7-ジフルオロ-2-{2-(トランス-4-エチルシクロヘキシ
ル)エチル}-6-(3,4,5-トリフルオロフェニル)-1,4-ジヒ
ドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ブチルシクロヘキシ
ル)エチル}-6-(3,4,5-トリフルオロフェニル)-1,4-ジヒ
ドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ペンチルシクロヘキ
シル)エチル}-6-(3,4,5-トリフルオロフェニル)-1,4-ジ
ヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ヘキシルシクロヘキ
シル)エチル}-6-(3,4,5-トリフルオロフェニル)-1,4-ジ
ヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-エチルシクロヘキシ
ル)エチル}-6-(4-フルオロフェニル)-1,4-ジヒドロナフ
タレン 5,7-ジフルオロ-2-{2-(トランス-4-プロピルシクロヘキ
シル)エチル}-6-(4-フルオロフェニル)-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-2-{2-(トランス-4-ブチルシクロヘキシ
ル)エチル}-6-(4-フルオロフェニル)-1,4-ジヒドロナフ
タレン 5,7-ジフルオロ-2-{2-(トランス-4-ペンチルシクロヘキ
シル)エチル}-6-(4-フルオロフェニル)-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-2-{2-(トランス-4-ヘキシルシクロヘキ
シル)エチル}-6-(4-フルオロフェニル)-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-2-{2-(トランス-4-エチルシクロヘキシ
ル)エチル}-6-(3,4-ジフルオロフェニル)-1,4-ジヒドロ
ナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-プロピルシクロヘキ
シル)エチル}-6-(3,4-ジフルオロフェニル)-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ブチルシクロヘキシ
ル)エチル}-6-(3,4-ジフルオロフェニル)-1,4-ジヒドロ
ナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ペンチルシクロヘキ
シル)エチル}-6-(3,4-ジフルオロフェニル)-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ヘキシルシクロヘキ
シル)エチル}-6-(3,4-ジフルオロフェニル)-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-エチルシクロヘキシ
ル)エチル}-6-(4-トリフルオロメトキシフェニル)-1,4-
ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-プロピルシクロヘキ
シル)エチル}-6-(4-トリフルオロメトキシフェニル)-1,
4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ブチルシクロヘキシ
ル)エチル}-6-(4-トリフルオロメトキシフェニル)-1,4-
ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ペンチルシクロヘキ
シル)エチル}-6-(4-トリフルオロメトキシフェニル)-1,
4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ヘキシルシクロヘキ
シル)エチル}-6-(4-トリフルオロメトキシフェニル)-1,
4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-エチルシクロヘキシ
ル)エチル}-6-(4-トリフルオロメトキシ-3-フルオロフ
ェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-プロピルシクロヘキ
シル)エチル}-6-(4-トリフルオロメトキシ-3-フルオロ
フェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ブチルシクロヘキシ
ル)エチル}-6-(4-トリフルオロメトキシ-3-フルオロフ
ェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ペンチルシクロヘキ
シル)エチル}-6-(4-トリフルオロメトキシ-3-フルオロ
フェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ヘキシルシクロヘキ
シル)エチル}-6-(4-トリフルオロメトキシ-3-フルオロ
フェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-エチルシクロヘキシ
ル)エチル}-6-(4-トリフルオロメトキシ-3,5-ジフルオ
ロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-プロピルシクロヘキ
シル)エチル}-6-(4-トリフルオロメトキシ-3,5-ジフル
オロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ブチルシクロヘキシ
ル)エチル}-6-(4-トリフルオロメトキシ-3,5-ジフルオ
ロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ペンチルシクロヘキ
シル)エチル}-6-(4-トリフルオロメトキシ-3,5-ジフル
オロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス-4-ヘキシルシクロヘキ
シル)エチル}-6-(4-トリフルオロメトキシ-3,5-ジフル
オロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-エチルビ
シクロヘキシル)エチル}-6-(3,4,5-トリフルオロフェニ
ル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-プロピル
ビシクロヘキシル)エチル}-6-(3,4,5-トリフルオロフェ
ニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ブチルビ
シクロヘキシル)エチル}-6-(3,4,5-トリフルオロフェニ
ル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ペンチル
ビシクロヘキシル)エチル}-6-(3,4,5-トリフルオロフェ
ニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ヘキシル
ビシクロヘキシル)エチル}-6-(3,4,5-トリフルオロフェ
ニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-エチルビ
シクロヘキシル)エチル}-6-(4-フルオロフェニル)-1,4-
ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-プロピル
ビシクロヘキシル)エチル}-6-(4-フルオロフェニル)-1,
4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ブチルビ
シクロヘキシル)エチル}-6-(4-フルオロフェニル)-1,4-
ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ペンチル
ビシクロヘキシル)エチル}-6-(4-フルオロフェニル)-1,
4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ヘキシル
ビシクロヘキシル)エチル}-6-(4-フルオロフェニル)-1,
4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-エチルビ
シクロヘキシル)エチル}-6-(3,4-ジフルオロフェニル)-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-プロピル
ビシクロヘキシル)エチル}-6-(3,4-ジフルオロフェニ
ル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ブチルビ
シクロヘキシル)エチル}-6-(3,4-ジフルオロフェニル)-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ペンチル
ビシクロヘキシル)エチル}-6-(3,4-ジフルオロフェニ
ル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ヘキシル
ビシクロヘキシル)エチル}-6-(3,4-ジフルオロフェニ
ル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-エチルビ
シクロヘキシル)エチル}-6-(4-トリフルオロメトキシフ
ェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-プロピル
ビシクロヘキシル)エチル}-6-(4-トリフルオロメトキシ
フェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ブチルビ
シクロヘキシル)エチル}-6-(4-トリフルオロメトキシフ
ェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ペンチル
ビシクロヘキシル)エチル}-6-(4-トリフルオロメトキシ
フェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ヘキシル
ビシクロヘキシル)エチル}-6-(4-トリフルオロメトキシ
フェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-エチルビ
シクロヘキシル)エチル}-6-(4-トリフルオロメトキシ-3
-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-プロピル
ビシクロヘキシル)エチル}-6-(4-トリフルオロメトキシ
-3-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ブチルビ
シクロヘキシル)エチル}-6-(4-トリフルオロメトキシ-3
-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ペンチル
ビシクロヘキシル)エチル}-6-(4-トリフルオロメトキシ
-3-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ヘキシル
ビシクロヘキシル)エチル}-6-(4-トリフルオロメトキシ
-3-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-エチルビ
シクロヘキシル)エチル}-6-(4-トリフルオロメトキシ-
3,5-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-プロピル
ビシクロヘキシル)エチル}-6-(4-トリフルオロメトキシ
-3,5-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ブチルビ
シクロヘキシル)エチル}-6-(4-トリフルオロメトキシ-
3,5-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ペンチル
ビシクロヘキシル)エチル}-6-(4-トリフルオロメトキシ
-3,5-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{2-(トランス,トランス-4'-ヘキシル
ビシクロヘキシル)エチル}-6-(4-トリフルオロメトキシ
-3,5-ジフルオロフェニル)-1,4-ジヒドロナフタレンSimilarly, the following compound was obtained. 5,7-Difluoro-2- {2- (trans-4-ethylcyclohexyl) ethyl} -6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-butylcyclohexyl) ethyl} -6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4- Pentylcyclohexyl) ethyl} -6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-hexylcyclohexyl) ethyl} -6- (3,4,5-Trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-ethylcyclohexyl) ethyl} -6- (4-fluorophenyl) -1 , 4-Dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-propylcyclohexyl) ethyl} -6- (4-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-butylcyclohexyl) ethyl } -6- (4-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-pentylcyclohexyl) ethyl} -6- (4-fluorophenyl) -1, 4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-hexylcyclohexyl) ethyl} -6- (4-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- { 2- (trans-4-ethylcyclohexyl) ethyl} -6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-propylcyclohexyl) ethyl } -6- (3,4-Difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-butylcyclohexyl) ethyl} -6- (3,4-difluorophenyl ) -1,4-Dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-pentylcyclohexyl) ethyl} -6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7 -Difluoro-2- {2- (tiger S-4-hexylcyclohexyl) ethyl} -6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-ethylcyclohexyl) ethyl} -6 -(4-trifluoromethoxyphenyl) -1,4-
Dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-propylcyclohexyl) ethyl} -6- (4-trifluoromethoxyphenyl) -1,
4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-butylcyclohexyl) ethyl} -6- (4-trifluoromethoxyphenyl) -1,4-
Dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-pentylcyclohexyl) ethyl} -6- (4-trifluoromethoxyphenyl) -1,
4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-hexylcyclohexyl) ethyl} -6- (4-trifluoromethoxyphenyl) -1,
4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-ethylcyclohexyl) ethyl} -6- (4-trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7 -Difluoro-2- {2- (trans-4-propylcyclohexyl) ethyl} -6- (4-trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2 -(Trans-4-butylcyclohexyl) ethyl} -6- (4-trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-pentyl Cyclohexyl) ethyl} -6- (4-trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-hexylcyclohexyl) ethyl} -6- (4-trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-ethylcyclohexyl) Ethyl} -6- (4-trifluoromethoxy-3,5-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-propylcyclohexyl) ethyl} -6- (4-Trifluoromethoxy-3,5-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-butylcyclohexyl) ethyl} -6- (4-trifluoro Methoxy-3,5-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-pentylcyclohexyl) ethyl} -6- (4-trifluoromethoxy-3,5 -Difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans-4-hexylcyclohexyl) ethyl} -6- (4-trifluoromethoxy-3,5-difluorophenyl)- 1,4-Dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-ethylbicyclohexyl) ethyl} -6- (3,4,5-trifluorophenyl) -1,4- The Hydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-propylbicyclohexyl) ethyl} -6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene 5, 7-Difluoro-2- {2- (trans, trans-4'-butylbicyclohexyl) ethyl} -6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro- 2- {2- (trans, trans-4'-pentylbicyclohexyl) ethyl} -6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2 -(Trans, trans-4'-hexylbicyclohexyl) ethyl} -6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, Trans-4'-ethylbicyclohexyl) ethyl} -6- (4-fluorophenyl) -1,4-
Dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-propylbicyclohexyl) ethyl} -6- (4-fluorophenyl) -1,
4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-butylbicyclohexyl) ethyl} -6- (4-fluorophenyl) -1,4-
Dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-pentylbicyclohexyl) ethyl} -6- (4-fluorophenyl) -1,
4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-hexylbicyclohexyl) ethyl} -6- (4-fluorophenyl) -1,
4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-ethylbicyclohexyl) ethyl} -6- (3,4-difluorophenyl)-
1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-propylbicyclohexyl) ethyl} -6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5 , 7-Difluoro-2- {2- (trans, trans-4'-butylbicyclohexyl) ethyl} -6- (3,4-difluorophenyl)-
1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-pentylbicyclohexyl) ethyl} -6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5 , 7-Difluoro-2- {2- (trans, trans-4'-hexylbicyclohexyl) ethyl} -6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-ethylbicyclohexyl) ethyl} -6- (4-trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans -4'-Propylbicyclohexyl) ethyl} -6- (4-trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-butylbicyclohexyl ) Ethyl} -6- (4-trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-pentylbicyclohexe ) Ethyl} -6- (4-trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4′-hexylbicyclohexyl) ethyl} -6- (4-Trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-ethylbicyclohexyl) ethyl} -6- (4-trifluoromethoxy- 3
-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-propylbicyclohexyl) ethyl} -6- (4-trifluoromethoxy
-3-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-butylbicyclohexyl) ethyl} -6- (4-trifluoromethoxy-3
-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-pentylbicyclohexyl) ethyl} -6- (4-trifluoromethoxy
-3-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-hexylbicyclohexyl) ethyl} -6- (4-trifluoromethoxy
-3-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-ethylbicyclohexyl) ethyl} -6- (4-trifluoromethoxy-
3,5-Difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-propylbicyclohexyl) ethyl} -6- (4-trifluoromethoxy
-3,5-Difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-butylbicyclohexyl) ethyl} -6- (4-trifluoromethoxy-
3,5-Difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-pentylbicyclohexyl) ethyl} -6- (4-trifluoromethoxy
-3,5-Difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- {2- (trans, trans-4'-hexylbicyclohexyl) ethyl} -6- (4-trifluoromethoxy
-3,5-difluorophenyl) -1,4-dihydronaphthalene

【０１２３】(実施例11) 5,6,7-トリフルオロ-2-プロ
ピル-1,4-ジヒドロナフタレンの合成 (11-a)5,6,7-トリフルオロ-1,2,3,4-テトラヒドロナフ
タレン-2-オンの合成 5,6,7-トリフルオロフェニル酢酸から、実施例1と同様
にして5,6,7-トリフルオロ-1,2,3,4-テトラヒドロナフ
タレン-2-オンを得た。 (11-b) 5,6,7-トリフルオロ-2-プロピル-1,4-ジヒドロ
ナフタレンの合成 上記(11-a)で得た5,6,7-トリフルオロ-1,2,3,4-テトラ
ヒドロナフタレン-2-オンから、実施例1と同様にして5,
6,7-トリフルオロ-2-プロピル-1,4-ジヒドロナフタレン
を得た。Example 11 Synthesis of 5,6,7-trifluoro-2-propyl-1,4-dihydronaphthalene (11-a) 5,6,7-Trifluoro-1,2,3,4 -Synthesis of tetrahydronaphthalen-2-one From 5,6,7-trifluorophenylacetic acid, 5,6,7-trifluoro-1,2,3,4-tetrahydronaphthalene-2-in the same manner as in Example 1. Got on. (11-b) Synthesis of 5,6,7-trifluoro-2-propyl-1,4-dihydronaphthalene 5,6,7-trifluoro-1,2,3, obtained in (11-a) above From 4-tetrahydronaphthalen-2-one, in the same manner as in Example 1, 5,
6,7-Trifluoro-2-propyl-1,4-dihydronaphthalene was obtained.

【０１２４】(実施例12) 5,6,7-トリフルオロ-2-{2-
(トランス-4-プロピルシクロヘキシル)エチル}-1,4-ジ
ヒドロナフタレンの合成 実施例11で得た5,6,7-トリフルオロ-1,2,3,4-テトラヒ
ドロナフタレン-2-オンから、実施例9と同様にして5,6,
7-トリフルオロ-2-{2-(トランス-4-プロピルシクロヘキ
シル)エチル}-1,4-ジヒドロナフタレンを得た。(Example 12) 5,6,7-trifluoro-2- {2-
Synthesis of (trans-4-propylcyclohexyl) ethyl} -1,4-dihydronaphthalene From 5,6,7-trifluoro-1,2,3,4-tetrahydronaphthalen-2-one obtained in Example 11, 5, 6, in the same manner as in Example 9.
7-Trifluoro-2- {2- (trans-4-propylcyclohexyl) ethyl} -1,4-dihydronaphthalene was obtained.

【０１２５】(実施例13)5,7-ジフルオロ-2-(4-プロピル
フェニル)-1,4-ジヒドロナフタレンの合成Example 13 Synthesis of 5,7-difluoro-2- (4-propylphenyl) -1,4-dihydronaphthalene

【化６３】 THF5mLにマグネシウム2.5gを懸濁させ、還流下、THF60m
Lに溶解した4-プロピルブロモベンゼンの20gを滴下し
た。更に1時間攪拌の後、25℃まで冷却し、トルエン60m
Lを加えた。次いでアスピレーターで減圧下、溶媒60mL
を溜去し、系内の溶媒の殆どがトルエンからに成るよう
にした。系内を25℃とし、実施例1で得た5,7-ジフルオ
ロ-1,2,3,4-テトラヒドロナフタレン-2-オンの14.3gを
トルエン50mLに溶解し滴下した。更に1時間の攪拌の
後、10％塩酸を加えた。酢酸エチルで抽出し、水、飽和
食塩水の順に洗浄し、無水硫酸マグネシウムで乾燥し
た。次いで、溶媒を溜去して15gの5,7-ジフルオロ-2-(4
-プロピルフェニル)-1,2,3,4-テトラヒドロナフタレン-
2-オール粗生成物を得た。次いで、実施例1と同様にし
て、5,7-ジフルオロ-2-(4-プロピルフェニル)-1,4-ジヒ
ドロナフタレンを得た。[Chemical formula 63] 2.5g of magnesium was suspended in 5mL of THF and THF60m under reflux.
20 g of 4-propylbromobenzene dissolved in L was added dropwise. After stirring for an additional 1 hour, cool to 25 ° C and add 60 m of toluene.
L was added. Then, under reduced pressure with an aspirator, 60 mL of solvent
Was distilled off so that most of the solvent in the system consisted of toluene. The system was set to 25 ° C., and 14.3 g of 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-one obtained in Example 1 was dissolved in 50 mL of toluene and added dropwise. After stirring for another hour, 10% hydrochloric acid was added. The mixture was extracted with ethyl acetate, washed with water and saturated brine in that order, and dried over anhydrous magnesium sulfate. Then the solvent was distilled off and 15 g of 5,7-difluoro-2- (4
-Propylphenyl) -1,2,3,4-tetrahydronaphthalene-
A 2-ol crude product was obtained. Then, in the same manner as in Example 1, 5,7-difluoro-2- (4-propylphenyl) -1,4-dihydronaphthalene was obtained.

【０１２６】同様にして以下の化合物を得た。 5,7-ジフルオロ-2-(4-エチルフェニル)-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-2-(4-ブチルフェニル)-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-2-(4-ペンチルフェニル)-1,4-ジヒドロ
ナフタレン 5,6,7-トリフルオロ-2-(4-エチルフェニル)-1,4-ジヒド
ロナフタレン 5,6,7-トリフルオロ-2-(4-プロピルフェニル)-1,4-ジヒ
ドロナフタレン 5,6,7-トリフルオロ-2-(4-ブチルフェニル)-1,4-ジヒド
ロナフタレン 5,6,7-トリフルオロ-2-(4-ペンチルフェニル)-1,4-ジヒ
ドロナフタレン 6-フルオロ-2-(4-エチルフェニル)-1,4-ジヒドロナフタ
レン 6-フルオロ-2-(4-プロピルフェニル)-1,4-ジヒドロナフ
タレン 6-フルオロ-2-(4-ブチルフェニル)-1,4-ジヒドロナフタ
レン 6-フルオロ-2-(4-ペンチルフェニル)-1,4-ジヒドロナフ
タレン 6-トリフルオロメトキシ-2-(4-エチルフェニル)-1,4-ジ
ヒドロナフタレン 6-トリフルオロメトキシ-2-(4-プロピルフェニル)-1,4-
ジヒドロナフタレン 6-トリフルオロメトキシ-2-(4-ブチルフェニル)-1,4-ジ
ヒドロナフタレン 6-トリフルオロメトキシ-2-(4-ペンチルフェニル)-1,4-
ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(4-エチル
フェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(4-プロピ
ルフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(4-ブチル
フェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(4-ペンチ
ルフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-エチル-2-フルオロフェニル)-1,4
-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピル-2-フルオロフェニル)-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチル-2-フルオロフェニル)-1,4
-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチル-2-フルオロフェニル)-
1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(4-エチル-2-フルオロフェニル)
-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(4-プロピル-2-フルオロフェニ
ル)-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(4-ブチル-2-フルオロフェニル)
-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(4-ペンチル-2-フルオロフェニ
ル)-1,4-ジヒドロナフタレン 6-フルオロ-2-(4-エチル-2-フルオロフェニル)-1,4-ジ
ヒドロナフタレン 6-フルオロ-2-(4-プロピル-2-フルオロフェニル)-1,4-
ジヒドロナフタレン 6-フルオロ-2-(4-ブチル-2-フルオロフェニル)-1,4-ジ
ヒドロナフタレン 6-フルオロ-2-(4-ペンチル-2-フルオロフェニル)-1,4-
ジヒドロナフタレン 6-トリフルオロメトキシ-2-(4-エチル-2-フルオロフェ
ニル)-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(4-プロピル-2-フルオロフ
ェニル)-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(4-ブチル-2-フルオロフェ
ニル)-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(4-ペンチル-2-フルオロフ
ェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(4-エチル-
2-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(4-プロピ
ル-2-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(4-ブチル-
2-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(4-ペンチ
ル-2-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-エチル-2,6-ジフルオロフェニル)
-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピル-2,6-ジフルオロフェニ
ル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチル-2,6-ジフルオロフェニル)
-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチル-2,6-ジフルオロフェニ
ル)-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(4-エチル-2,6-ジフルオロフェ
ニル)-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(4-プロピル-2,6-ジフルオロフ
ェニル)-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(4-ブチル-2,6-ジフルオロフェ
ニル)-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(4-ペンチル-2,6-ジフルオロフ
ェニル)-1,4-ジヒドロナフタレン 6-フルオロ-2-(4-エチル-2,6-ジフルオロフェニル)-1,4
-ジヒドロナフタレン 6-フルオロ-2-(4-プロピル-2,6-ジフルオロフェニル)-
1,4-ジヒドロナフタレン 6-フルオロ-2-(4-ブチル-2,6-ジフルオロフェニル)-1,4
-ジヒドロナフタレン 6-フルオロ-2-(4-ペンチル-2,6-ジフルオロフェニル)-
1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(4-エチル-2,6-ジフルオロ
フェニル)-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(4-プロピル-2,6-ジフルオ
ロフェニル)-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(4-ブチル-2,6-ジフルオロ
フェニル)-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(4-ペンチル-2,6-ジフルオ
ロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(4-エチル-
2,6-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(4-プロピ
ル-2,6-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(4-ブチル-
2,6-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(4-ペンチ
ル-2,6-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{4-(トランス-4-エチルシクロヘキシ
ル)フェニル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{4-(トランス-4-プロピルシクロヘキ
シル)フェニル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{4-(トランス-4-ブチルシクロヘキシ
ル)フェニル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{4-(トランス-4-ペンチルシクロヘキ
シル)フェニル}-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-{4-(トランス-4-エチルシクロヘ
キシル)フェニル}-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-{4-(トランス-4-プロピルシクロ
ヘキシル)フェニル}-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-{4-(トランス-4-ブチルシクロヘ
キシル)フェニル}-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-{4-(トランス-4-ペンチルシクロ
ヘキシル)フェニル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{4-(トランス-4-エチルシクロヘキシル)
フェニル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{4-(トランス-4-プロピルシクロヘキシ
ル)フェニル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{4-(トランス-4-ブチルシクロヘキシル)
フェニル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{4-(トランス-4-ペンチルシクロヘキシ
ル)フェニル}-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-{4-(トランス-4-エチルシク
ロヘキシル)フェニル}-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-{4-(トランス-4-プロピルシ
クロヘキシル)フェニル}-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-{4-(トランス-4-ブチルシク
ロヘキシル)フェニル}-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-{4-(トランス-4-ペンチルシ
クロヘキシル)フェニル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{4-(トラン
ス-4-エチルシクロヘキシル)フェニル}-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{4-(トラン
ス-4-プロピルシクロヘキシル)フェニル}-1,4-ジヒドロ
ナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{4-(トラン
ス-4-ブチルシクロヘキシル)フェニル}-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{4-(トラン
ス-4-ペンチルシクロヘキシル)フェニル}-1,4-ジヒドロ
ナフタレン 5,7-ジフルオロ-2-{4-(トランス-4-エチル-2-フルオロ
シクロヘキシル)フェニル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{4-(トランス-4-プロピル-2-フルオ
ロシクロヘキシル)フェニル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{4-(トランス-4-ブチル-2-フルオロ
シクロヘキシル)フェニル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{4-(トランス-4-ペンチル-2-フルオ
ロシクロヘキシル)フェニル}-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-{4-(トランス-4-エチル-2-フル
オロシクロヘキシル)フェニル}-1,4-ジヒドロナフタレ
ン 5,6,7-トリフルオロ-2-{4-(トランス-4-プロピル-2-フ
ルオロシクロヘキシル)フェニル}-1,4-ジヒドロナフタ
レン 5,6,7-トリフルオロ-2-{4-(トランス-4-ブチル-2-フル
オロシクロヘキシル)フェニル}-1,4-ジヒドロナフタレ
ン 5,6,7-トリフルオロ-2-{4-(トランス-4-ペンチル-2-フ
ルオロシクロヘキシル)フェニル}-1,4-ジヒドロナフタ
レン 6-フルオロ-2-{4-(トランス-4-エチル-2-フルオロシク
ロヘキシル)フェニル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{4-(トランス-4-プロピル-2-フルオロシ
クロヘキシル)フェニル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{4-(トランス-4-ブチル-2-フルオロシク
ロヘキシル)フェニル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{4-(トランス-4-ペンチル-2-フルオロシ
クロヘキシル)フェニル}-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-{4-(トランス-4-エチル-2-
フルオロシクロヘキシル)フェニル}-1,4-ジヒドロナフ
タレン 6-トリフルオロメトキシ-2-{4-(トランス-4-プロピル-2
-フルオロシクロヘキシル)フェニル}-1,4-ジヒドロナフ
タレン 6-トリフルオロメトキシ-2-{4-(トランス-4-ブチル-2-
フルオロシクロヘキシル)フェニル}-1,4-ジヒドロナフ
タレン 6-トリフルオロメトキシ-2-{4-(トランス-4-ペンチル-2
-フルオロシクロヘキシル)フェニル}-1,4-ジヒドロナフ
タレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{4-(トラン
ス-4-エチル-2-フルオロシクロヘキシル)フェニル}-1,4
-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{4-(トラン
ス-4-プロピル-2-フルオロシクロヘキシル)フェニル}-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{4-(トラン
ス-4-ブチル-2-フルオロシクロヘキシル)フェニル}-1,4
-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{4-(トラン
ス-4-ペンチル-2-フルオロシクロヘキシル)フェニル}-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-{4-(トランス-4-エチル-2,6-ジフル
オロシクロヘキシル)フェニル}-1,4-ジヒドロナフタレ
ン 5,7-ジフルオロ-2-{4-(トランス-4-プロピル-2,6-ジフ
ルオロシクロヘキシル)フェニル}-1,4-ジヒドロナフタ
レン 5,7-ジフルオロ-2-{4-(トランス-4-ブチル-2,6-ジフル
オロシクロヘキシル)フェニル}-1,4-ジヒドロナフタレ
ン 5,7-ジフルオロ-2-{4-(トランス-4-ペンチル-2,6-ジフ
ルオロシクロヘキシル)フェニル}-1,4-ジヒドロナフタ
レン 5,6,7-トリフルオロ-2-{4-(トランス-4-エチル-2,6-ジ
フルオロシクロヘキシル)フェニル}-1,4-ジヒドロナフ
タレン 5,6,7-トリフルオロ-2-{4-(トランス-4-プロピル-2,6-
ジフルオロシクロヘキシル)フェニル}-1,4-ジヒドロナ
フタレン 5,6,7-トリフルオロ-2-{4-(トランス-4-ブチル-2,6-ジ
フルオロシクロヘキシル)フェニル}-1,4-ジヒドロナフ
タレン 5,6,7-トリフルオロ-2-{4-(トランス-4-ペンチル-2,6-
ジフルオロシクロヘキシル)フェニル}-1,4-ジヒドロナ
フタレン 6-フルオロ-2-{4-(トランス-4-エチル-2,6-ジフルオロ
シクロヘキシル)フェニル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{4-(トランス-4-プロピル-2,6-ジフルオ
ロシクロヘキシル)フェニル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{4-(トランス-4-ブチル-2,6-ジフルオロ
シクロヘキシル)フェニル}-1,4-ジヒドロナフタレン 6-フルオロ-2-{4-(トランス-4-ペンチル-2,6-ジフルオ
ロシクロヘキシル)フェニル}-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-{4-(トランス-4-エチル-2,6
-ジフルオロシクロヘキシル)フェニル}-1,4-ジヒドロナ
フタレン 6-トリフルオロメトキシ-2-{4-(トランス-4-プロピル-
2,6-ジフルオロシクロヘキシル)フェニル}-1,4-ジヒド
ロナフタレン 6-トリフルオロメトキシ-2-{4-(トランス-4-ブチル-2,6
-ジフルオロシクロヘキシル)フェニル}-1,4-ジヒドロナ
フタレン 6-トリフルオロメトキシ-2-{4-(トランス-4-ペンチル-
2,6-ジフルオロシクロヘキシル)フェニル}-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{4-(トラン
ス-4-エチル-2,6-ジフルオロシクロヘキシル)フェニル}
-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{4-(トラン
ス-4-プロピル-2,6-ジフルオロシクロヘキシル)フェニ
ル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{4-(トラン
ス-4-ブチル-2,6-ジフルオロシクロヘキシル)フェニル}
-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-{4-(トラン
ス-4-ペンチル-2,6-ジフルオロシクロヘキシル)フェニ
ル}-1,4-ジヒドロナフタレンSimilarly, the following compound was obtained. 5,7-Difluoro-2- (4-ethylphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-butylphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-Pentylphenyl) -1,4-dihydronaphthalene 5,6,7-trifluoro-2- (4-ethylphenyl) -1,4-dihydronaphthalene 5,6,7-trifluoro-2- (4 -Propylphenyl) -1,4-dihydronaphthalene 5,6,7-trifluoro-2- (4-butylphenyl) -1,4-dihydronaphthalene 5,6,7-trifluoro-2- (4-pentyl Phenyl) -1,4-dihydronaphthalene 6-fluoro-2- (4-ethylphenyl) -1,4-dihydronaphthalene 6-fluoro-2- (4-propylphenyl) -1,4-dihydronaphthalene 6-fluoro -2- (4-Butylphenyl) -1,4-dihydronaphthalene 6-fluoro-2- (4-pentylphenyl) -1,4-dihydronaphthalene 6-trifluoromethoxy-2- (4-ethylphenyl)- 1,4-dihydronaphthalene 6-trifluorome Carboxymethyl-2- (4-propylphenyl) -1,4
Dihydronaphthalene 6-trifluoromethoxy-2- (4-butylphenyl) -1,4-dihydronaphthalene 6-trifluoromethoxy-2- (4-pentylphenyl) -1,4-
Dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (4-ethylphenyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (4-propylphenyl)- 1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (4-butylphenyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (4- Pentylphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-ethyl-2-fluorophenyl) -1,4
-Dihydronaphthalene 5,7-difluoro-2- (4-propyl-2-fluorophenyl)-
1,4-dihydronaphthalene 5,7-difluoro-2- (4-butyl-2-fluorophenyl) -1,4
-Dihydronaphthalene 5,7-difluoro-2- (4-pentyl-2-fluorophenyl)-
1,4-dihydronaphthalene 5,6,7-trifluoro-2- (4-ethyl-2-fluorophenyl)
-1,4-dihydronaphthalene 5,6,7-trifluoro-2- (4-propyl-2-fluorophenyl) -1,4-dihydronaphthalene 5,6,7-trifluoro-2- (4-butyl) -2-fluorophenyl)
-1,4-dihydronaphthalene 5,6,7-trifluoro-2- (4-pentyl-2-fluorophenyl) -1,4-dihydronaphthalene 6-fluoro-2- (4-ethyl-2-fluorophenyl) ) -1,4-Dihydronaphthalene 6-fluoro-2- (4-propyl-2-fluorophenyl) -1,4-
Dihydronaphthalene 6-fluoro-2- (4-butyl-2-fluorophenyl) -1,4-dihydronaphthalene 6-fluoro-2- (4-pentyl-2-fluorophenyl) -1,4-
Dihydronaphthalene 6-trifluoromethoxy-2- (4-ethyl-2-fluorophenyl) -1,4-dihydronaphthalene 6-trifluoromethoxy-2- (4-propyl-2-fluorophenyl) -1,4- Dihydronaphthalene 6-trifluoromethoxy-2- (4-butyl-2-fluorophenyl) -1,4-dihydronaphthalene 6-trifluoromethoxy-2- (4-pentyl-2-fluorophenyl) -1,4- Dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (4-ethyl-
2-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (4-propyl-2-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-6 -Trifluoromethoxy-2- (4-butyl-
2-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (4-pentyl-2-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2 -(4-Ethyl-2,6-difluorophenyl)
-1,4-dihydronaphthalene 5,7-difluoro-2- (4-propyl-2,6-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-butyl-2,6 -Difluorophenyl)
-1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentyl-2,6-difluorophenyl) -1,4-dihydronaphthalene 5,6,7-trifluoro-2- (4-ethyl- 2,6-Difluorophenyl) -1,4-dihydronaphthalene 5,6,7-trifluoro-2- (4-propyl-2,6-difluorophenyl) -1,4-dihydronaphthalene 5,6,7- Trifluoro-2- (4-butyl-2,6-difluorophenyl) -1,4-dihydronaphthalene 5,6,7-trifluoro-2- (4-pentyl-2,6-difluorophenyl) -1, 4-dihydronaphthalene 6-fluoro-2- (4-ethyl-2,6-difluorophenyl) -1,4
-Dihydronaphthalene 6-fluoro-2- (4-propyl-2,6-difluorophenyl)-
1,4-dihydronaphthalene 6-fluoro-2- (4-butyl-2,6-difluorophenyl) -1,4
-Dihydronaphthalene 6-fluoro-2- (4-pentyl-2,6-difluorophenyl)-
1,4-dihydronaphthalene 6-trifluoromethoxy-2- (4-ethyl-2,6-difluorophenyl) -1,4-dihydronaphthalene 6-trifluoromethoxy-2- (4-propyl-2,6- Difluorophenyl) -1,4-dihydronaphthalene 6-trifluoromethoxy-2- (4-butyl-2,6-difluorophenyl) -1,4-dihydronaphthalene 6-trifluoromethoxy-2- (4-pentyl- 2,6-Difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (4-ethyl-
2,6-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (4-propyl-2,6-difluorophenyl) -1,4-dihydronaphthalene 5,7 -Difluoro-6-trifluoromethoxy-2- (4-butyl-
2,6-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (4-pentyl-2,6-difluorophenyl) -1,4-dihydronaphthalene 5,7 -Difluoro-2- {4- (trans-4-ethylcyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {4- (trans-4-propylcyclohexyl) phenyl} -1,4 -Dihydronaphthalene 5,7-difluoro-2- {4- (trans-4-butylcyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {4- (trans-4-pentylcyclohexyl) Phenyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2- {4- (trans-4-ethylcyclohexyl) phenyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2 -{4- (trans-4-propylcyclohexyl) phenyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2- {4- (trans-4-butylcyclohexyl) phenyl Phenyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2- {4- (trans-4-pentylcyclohexyl) phenyl} -1,4-dihydronaphthalene 6-fluoro-2- {4- ( Trans-4-ethylcyclohexyl)
Phenyl} -1,4-dihydronaphthalene 6-fluoro-2- {4- (trans-4-propylcyclohexyl) phenyl} -1,4-dihydronaphthalene 6-fluoro-2- {4- (trans-4-butyl Cyclohexyl)
Phenyl} -1,4-dihydronaphthalene 6-fluoro-2- {4- (trans-4-pentylcyclohexyl) phenyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {4- (trans-4 -Ethylcyclohexyl) phenyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {4- (trans-4-propylcyclohexyl) phenyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- { 4- (trans-4-butylcyclohexyl) phenyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {4- (trans-4-pentylcyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7 -Difluoro-6-trifluoromethoxy-2- {4- (trans-4-ethylcyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {4- (trans -4-Propylcyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-diph Oro-6-trifluoromethoxy-2- {4- (trans-4-butylcyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {4- (trans- 4-Pentylcyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {4- (trans-4-ethyl-2-fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7- Difluoro-2- {4- (trans-4-propyl-2-fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {4- (trans-4-butyl-2-fluorocyclohexyl ) Phenyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {4- (trans-4-pentyl-2-fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,6,7-trifluoro -2- {4- (trans-4-ethyl-2-fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2- {4- (tra 4-propyl-2-fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2- {4- (trans-4-butyl-2-fluorocyclohexyl) phenyl} -1 , 4-Dihydronaphthalene 5,6,7-trifluoro-2- {4- (trans-4-pentyl-2-fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-fluoro-2- {4- ( Trans-4-ethyl-2-fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-fluoro-2- {4- (trans-4-propyl-2-fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-fluoro-2- {4- (trans-4-butyl-2-fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-fluoro-2- {4- (trans-4-pentyl-2-fluorocyclohexyl ) Phenyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {4- (trans-4-ethyl-2-
Fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {4- (trans-4-propyl-2
-Fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {4- (trans-4-butyl-2-
Fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {4- (trans-4-pentyl-2
-Fluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {4- (trans-4-ethyl-2-fluorocyclohexyl) phenyl} -1,4
-Dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {4- (trans-4-propyl-2-fluorocyclohexyl) phenyl}-
1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {4- (trans-4-butyl-2-fluorocyclohexyl) phenyl} -1,4
-Dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {4- (trans-4-pentyl-2-fluorocyclohexyl) phenyl}-
1,4-Dihydronaphthalene 5,7-difluoro-2- {4- (trans-4-ethyl-2,6-difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {4 -(Trans-4-propyl-2,6-difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-difluoro-2- {4- (trans-4-butyl-2,6-difluorocyclohexyl) phenyl } -1,4-Dihydronaphthalene 5,7-difluoro-2- {4- (trans-4-pentyl-2,6-difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,6,7-trifluoro -2- {4- (trans-4-ethyl-2,6-difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2- {4- (trans-4-propyl- 2,6-
Difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,6,7-trifluoro-2- {4- (trans-4-butyl-2,6-difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5 , 6,7-Trifluoro-2- {4- (trans-4-pentyl-2,6-
Difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-fluoro-2- {4- (trans-4-ethyl-2,6-difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-fluoro-2- {4- (trans-4-propyl-2,6-difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-fluoro-2- {4- (trans-4-butyl-2,6-difluorocyclohexyl) phenyl } -1,4-Dihydronaphthalene 6-fluoro-2- {4- (trans-4-pentyl-2,6-difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {4 -(Trans-4-ethyl-2,6
-Difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {4- (trans-4-propyl-
2,6-Difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {4- (trans-4-butyl-2,6
-Difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 6-trifluoromethoxy-2- {4- (trans-4-pentyl-
2,6-Difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {4- (trans-4-ethyl-2,6-difluorocyclohexyl) phenyl}
-1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {4- (trans-4-propyl-2,6-difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7 -Difluoro-6-trifluoromethoxy-2- {4- (trans-4-butyl-2,6-difluorocyclohexyl) phenyl}
-1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- {4- (trans-4-pentyl-2,6-difluorocyclohexyl) phenyl} -1,4-dihydronaphthalene

【０１２７】(実施例14) 5,7-ジフルオロ-2-(4-プロピ
ルフェニル)-6-(3,4,5-トリフルオロフェニル)-1,4-ジ
ヒドロナフタレンの合成 実施例13で得た5,7-ジフルオロ-2-(4-プロピルフェニ
ル)-1,4-ジヒドロナフタレンから、実施例3と同様にし
て5,7-ジフルオロ-2-(4-プロピルフェニル)-6-(3,4,5-
トリフルオロフェニル)-1,4-ジヒドロナフタレンを得
た。Example 14 Synthesis of 5,7-difluoro-2- (4-propylphenyl) -6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene Obtained in Example 13 From 5,7-difluoro-2- (4-propylphenyl) -1,4-dihydronaphthalene, 5,7-difluoro-2- (4-propylphenyl) -6- (3 , 4,5-
Trifluorophenyl) -1,4-dihydronaphthalene was obtained.

【０１２８】同様にして以下の化合物を得た。 5,7-ジフルオロ-2-(4-エチルフェニル)-6-(3,4,5-トリ
フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチルフェニル)-6-(3,4,5-トリ
フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチルフェニル)-6-(3,4,5-ト
リフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-エチル-2-フルオロフェニル)-6-
(3,4,5-トリフルオロフェニル)-1,4-ジヒドロナフタレ
ン 5,7-ジフルオロ-2-(4-プロピル-2-フルオロフェニル)-6
-(3,4,5-トリフルオロフェニル)-1,4-ジヒドロナフタレ
ン 5,7-ジフルオロ-2-(4-ブチル-2-フルオロフェニル)-6-
(3,4,5-トリフルオロフェニル)-1,4-ジヒドロナフタレ
ン 5,7-ジフルオロ-2-(4-ペンチル-2-フルオロフェニル)-6
-(3,4,5-トリフルオロフェニル)-1,4-ジヒドロナフタレ
ン 5,7-ジフルオロ-2-(4-エチルフェニル)-6-(3,4-ジフル
オロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピルフェニル)-6-(3,4-ジフ
ルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチルフェニル)-6-(3,4-ジフル
オロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチルフェニル)-6-(3,4-ジフ
ルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-エチル-2-フルオロフェニル)-6-
(3,4-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピル-2-フルオロフェニル)-6
-(3,4-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチル-2-フルオロフェニル)-6-
(3,4-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチル-2-フルオロフェニル)-6
-(3,4-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-エチル-2,6-ジフルオロフェニル)
-6-(3,4-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピル-2,6-ジフルオロフェニ
ル)-6-(3,4-ジフルオロフェニル)-1,4-ジヒドロナフタ
レン 5,7-ジフルオロ-2-(4-ブチル-2,6-ジフルオロフェニル)
-6-(3,4-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチル-2,6-ジフルオロフェニ
ル)-6-(3,4-ジフルオロフェニル)-1,4-ジヒドロナフタ
レン 5,7-ジフルオロ-2-(4-エチルフェニル)-6-(4-フルオロ
フェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピルフェニル)-6-(4-フルオ
ロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチルフェニル)-6-(4-フルオロ
フェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチルフェニル)-6-(4-フルオ
ロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-エチル-2-フルオロフェニル)-6-
(4-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピル-2-フルオロフェニル)-6
-(4-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチル-2-フルオロフェニル)-6-
(4-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチル-2-フルオロフェニル)-6
-(4-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-エチル-2,6-ジフルオロフェニル)
-6-(4-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピル-2,6-ジフルオロフェニ
ル)-6-(4-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチル-2,6-ジフルオロフェニル)
-6-(4-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチル-2,6-ジフルオロフェニ
ル)-6-(4-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-エチルフェニル)-6-(4-トリフル
オロメトキシフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピルフェニル)-6-(4-トリフ
ルオロメトキシフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチルフェニル)-6-(4-トリフル
オロメトキシフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチルフェニル)-6-(4-トリフ
ルオロメトキシフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-エチル-2,6-ジフルオロフェニル)
-6-(4-トリフルオロメトキシフェニル)-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-2-(4-プロピル-2,6-ジフルオロフェニ
ル)-6-(4-トリフルオロメトキシフェニル)-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-2-(4-ブチル-2,6-ジフルオロフェニル)
-6-(4-トリフルオロメトキシフェニル)-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-2-(4-ペンチル-2,6-ジフルオロフェニ
ル)-6-(4-トリフルオロメトキシフェニル)-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-2-(4-エチルフェニル)-6-(4-トリフル
オロメトキシ-3-フルオロフェニル)-1,4-ジヒドロナフ
タレン 5,7-ジフルオロ-2-(4-プロピルフェニル)-6-(4-トリフ
ルオロメトキシ-3-フルオロフェニル)-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-2-(4-ブチルフェニル)-6-(4-トリフル
オロメトキシ-3-フルオロフェニル)-1,4-ジヒドロナフ
タレン 5,7-ジフルオロ-2-(4-ペンチルフェニル)-6-(4-トリフ
ルオロメトキシ-3-フルオロフェニル)-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-2-(4-エチル-2-フルオロフェニル)-6-
(4-トリフルオロメトキシ-3-フルオロフェニル)-1,4-ジ
ヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピル-2-フルオロフェニル)-6
-(4-トリフルオロメトキシ-3-フルオロフェニル)-1,4-
ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチル-2-フルオロフェニル)-6-
(4-トリフルオロメトキシ-3-フルオロフェニル)-1,4-ジ
ヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチル-2-フルオロフェニル)-6
-(4-トリフルオロメトキシ-3-フルオロフェニル)-1,4-
ジヒドロナフタレン 5,7-ジフルオロ-2-(4-エチル-2,6-ジフルオロフェニル)
-6-(4-トリフルオロメトキシ-3-フルオロフェニル)-1,4
-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピル-2,6-ジフルオロフェニ
ル)-6-(4-トリフルオロメトキシ-3-フルオロフェニル)-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチル-2,6-ジフルオロフェニル)
-6-(4-トリフルオロメトキシ-3-フルオロフェニル)-1,4
-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチル-2,6-ジフルオロフェニ
ル)-6-(4-トリフルオロメトキシ-3-フルオロフェニル)-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-エチルフェニル)-6-(4-トリフル
オロメトキシ-3,5-ジフルオロフェニル)-1,4-ジヒドロ
ナフタレン 5,7-ジフルオロ-2-(4-プロピルフェニル)-6-(4-トリフ
ルオロメトキシ-3,5-ジフルオロフェニル)-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-2-(4-ブチルフェニル)-6-(4-トリフル
オロメトキシ-3,5-ジフルオロフェニル)-1,4-ジヒドロ
ナフタレン 5,7-ジフルオロ-2-(4-ペンチルフェニル)-6-(4-トリフ
ルオロメトキシ-3,5-ジフルオロフェニル)-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-2-(4-エチル-2-フルオロフェニル)-6-
(4-トリフルオロメトキシ-3,5-ジフルオロフェニル)-1,
4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピル-2-フルオロフェニル)-6
-(4-トリフルオロメトキシ-3,5-ジフルオロフェニル)-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチル-2-フルオロフェニル)-6-
(4-トリフルオロメトキシ-3,5-ジフルオロフェニル)-1,
4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチル-2-フルオロフェニル)-6
-(4-トリフルオロメトキシ-3,5-ジフルオロフェニル)-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-エチル-2,6-ジフルオロフェニル)
-6-(4-トリフルオロメトキシ-3,5-ジフルオロフェニル)
-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-プロピル-2,6-ジフルオロフェニ
ル)-6-(4-トリフルオロメトキシ-3,5-ジフルオロフェニ
ル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ブチル-2,6-ジフルオロフェニル)
-6-(4-トリフルオロメトキシ-3,5-ジフルオロフェニル)
-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(4-ペンチル-2,6-ジフルオロフェニ
ル)-6-(4-トリフルオロメトキシ-3,5-ジフルオロフェニ
ル)-1,4-ジヒドロナフタレンSimilarly, the following compounds were obtained. 5,7-Difluoro-2- (4-ethylphenyl) -6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-butylphenyl)- 6- (3,4,5-Trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentylphenyl) -6- (3,4,5-trifluorophenyl) -1 , 4-Dihydronaphthalene 5,7-difluoro-2- (4-ethyl-2-fluorophenyl) -6-
(3,4,5-Trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-propyl-2-fluorophenyl) -6
-(3,4,5-Trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-butyl-2-fluorophenyl) -6-
(3,4,5-Trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentyl-2-fluorophenyl) -6
-(3,4,5-Trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-ethylphenyl) -6- (3,4-difluorophenyl) -1,4-dihydro Naphthalene 5,7-difluoro-2- (4-propylphenyl) -6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-butylphenyl) -6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentylphenyl) -6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7 -Difluoro-2- (4-ethyl-2-fluorophenyl) -6-
(3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-propyl-2-fluorophenyl) -6
-(3,4-Difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-butyl-2-fluorophenyl) -6-
(3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentyl-2-fluorophenyl) -6
-(3,4-Difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-ethyl-2,6-difluorophenyl)
-6- (3,4-Difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-propyl-2,6-difluorophenyl) -6- (3,4-difluorophenyl)- 1,4-dihydronaphthalene 5,7-difluoro-2- (4-butyl-2,6-difluorophenyl)
-6- (3,4-Difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentyl-2,6-difluorophenyl) -6- (3,4-difluorophenyl)- 1,4-dihydronaphthalene 5,7-difluoro-2- (4-ethylphenyl) -6- (4-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-propylphenyl) -6- (4-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-butylphenyl) -6- (4-fluorophenyl) -1,4-dihydronaphthalene 5,7- Difluoro-2- (4-pentylphenyl) -6- (4-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-ethyl-2-fluorophenyl) -6-
(4-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-propyl-2-fluorophenyl) -6
-(4-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-butyl-2-fluorophenyl) -6-
(4-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentyl-2-fluorophenyl) -6
-(4-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-ethyl-2,6-difluorophenyl)
-6- (4-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-propyl-2,6-difluorophenyl) -6- (4-fluorophenyl) -1,4- Dihydronaphthalene 5,7-difluoro-2- (4-butyl-2,6-difluorophenyl)
-6- (4-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentyl-2,6-difluorophenyl) -6- (4-fluorophenyl) -1,4- Dihydronaphthalene 5,7-difluoro-2- (4-ethylphenyl) -6- (4-trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-propylphenyl) -6 -(4-trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-butylphenyl) -6- (4-trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5, 7-Difluoro-2- (4-pentylphenyl) -6- (4-trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-ethyl-2,6-difluorophenyl)
-6- (4-trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-propyl-2,6-difluorophenyl) -6- (4-trifluoromethoxyphenyl)- 1,4-dihydronaphthalene 5,7-difluoro-2- (4-butyl-2,6-difluorophenyl)
-6- (4-trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentyl-2,6-difluorophenyl) -6- (4-trifluoromethoxyphenyl)- 1,4-dihydronaphthalene 5,7-difluoro-2- (4-ethylphenyl) -6- (4-trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-Propylphenyl) -6- (4-trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-butylphenyl) -6- (4-trifluoro Methoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentylphenyl) -6- (4-trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-ethyl-2-fluorophenyl) -6-
(4-Trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-propyl-2-fluorophenyl) -6
-(4-trifluoromethoxy-3-fluorophenyl) -1,4-
Dihydronaphthalene 5,7-difluoro-2- (4-butyl-2-fluorophenyl) -6-
(4-trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentyl-2-fluorophenyl) -6
-(4-trifluoromethoxy-3-fluorophenyl) -1,4-
Dihydronaphthalene 5,7-difluoro-2- (4-ethyl-2,6-difluorophenyl)
-6- (4-trifluoromethoxy-3-fluorophenyl) -1,4
-Dihydronaphthalene 5,7-difluoro-2- (4-propyl-2,6-difluorophenyl) -6- (4-trifluoromethoxy-3-fluorophenyl)-
1,4-dihydronaphthalene 5,7-difluoro-2- (4-butyl-2,6-difluorophenyl)
-6- (4-trifluoromethoxy-3-fluorophenyl) -1,4
-Dihydronaphthalene 5,7-difluoro-2- (4-pentyl-2,6-difluorophenyl) -6- (4-trifluoromethoxy-3-fluorophenyl)-
1,4-dihydronaphthalene 5,7-difluoro-2- (4-ethylphenyl) -6- (4-trifluoromethoxy-3,5-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro- 2- (4-Propylphenyl) -6- (4-trifluoromethoxy-3,5-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-butylphenyl) -6- ( 4-trifluoromethoxy-3,5-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentylphenyl) -6- (4-trifluoromethoxy-3,5-difluorophenyl ) -1,4-Dihydronaphthalene 5,7-difluoro-2- (4-ethyl-2-fluorophenyl) -6-
(4-trifluoromethoxy-3,5-difluorophenyl) -1,
4-dihydronaphthalene 5,7-difluoro-2- (4-propyl-2-fluorophenyl) -6
-(4-trifluoromethoxy-3,5-difluorophenyl)-
1,4-dihydronaphthalene 5,7-difluoro-2- (4-butyl-2-fluorophenyl) -6-
(4-trifluoromethoxy-3,5-difluorophenyl) -1,
4-dihydronaphthalene 5,7-difluoro-2- (4-pentyl-2-fluorophenyl) -6
-(4-trifluoromethoxy-3,5-difluorophenyl)-
1,4-dihydronaphthalene 5,7-difluoro-2- (4-ethyl-2,6-difluorophenyl)
-6- (4-trifluoromethoxy-3,5-difluorophenyl)
-1,4-dihydronaphthalene 5,7-difluoro-2- (4-propyl-2,6-difluorophenyl) -6- (4-trifluoromethoxy-3,5-difluorophenyl) -1,4-dihydro Naphthalene 5,7-difluoro-2- (4-butyl-2,6-difluorophenyl)
-6- (4-trifluoromethoxy-3,5-difluorophenyl)
-1,4-dihydronaphthalene 5,7-difluoro-2- (4-pentyl-2,6-difluorophenyl) -6- (4-trifluoromethoxy-3,5-difluorophenyl) -1,4-dihydro Naphthalene

【０１２９】(実施例15) 5,7-ジフルオロ-2-(トランス
-4-プロピルシクロヘキシル)-1,4-ジヒドロナフタレン
の合成 4-プロピルブロモベンゼンに代えてトランス-4-プロピ
ル-1-ブロモシクロヘキサンを用いて、実施例13と同様
にして5,7-ジフルオロ-2-(トランス-4-プロピルシクロ
ヘキシル)-1,4-ジヒドロナフタレンを得た。Example 15 5,7-Difluoro-2- (trans
Synthesis of 4-propylcyclohexyl) -1,4-dihydronaphthalene Using trans-4-propyl-1-bromocyclohexane in place of 4-propylbromobenzene and in the same manner as in Example 13, 2- (trans-4-propylcyclohexyl) -1,4-dihydronaphthalene was obtained.

【０１３０】同様にして以下の化合物を得た。 5,7-ジフルオロ-2-(トランス-4-エチルシクロヘキシル)
-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス-4-ペンチルシクロヘキシ
ル)-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(トランス-4-エチルシクロヘキ
シル)-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(トランス-4-プロピルシクロヘ
キシル)-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(トランス-4-ペンチルシクロヘ
キシル)-1,4-ジヒドロナフタレン 6-フルオロ-2-(トランス-4-エチルシクロヘキシル)-1,4
-ジヒドロナフタレン 6-フルオロ-2-(トランス-4-プロピルシクロヘキシル)-
1,4-ジヒドロナフタレン 6-フルオロ-2-(トランス-4-ペンチルシクロヘキシル)-
1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(トランス-4-エチルシクロ
ヘキシル)-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(トランス-4-プロピルシク
ロヘキシル)-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(トランス-4-ペンチルシク
ロヘキシル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(トランス-
4-エチルシクロヘキシル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(トランス-
4-プロピルシクロヘキシル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(トランス-
4-ペンチルシクロヘキシル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-エチルビシ
クロヘキシル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-プロピルビ
シクロヘキシル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-ペンチルビ
シクロヘキシル)-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(トランス,トランス-4'-エチル
ビシクロヘキシル)-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(トランス,トランス-4'-プロピ
ルビシクロヘキシル)-1,4-ジヒドロナフタレン 5,6,7-トリフルオロ-2-(トランス,トランス-4'-ペンチ
ルビシクロヘキシル)-1,4-ジヒドロナフタレン 6-フルオロ-2-(トランス,トランス-4'-エチルビシクロ
ヘキシル)-1,4-ジヒドロナフタレン 6-フルオロ-2-(トランス,トランス-4'-プロピルビシク
ロヘキシル)-1,4-ジヒドロナフタレン 6-フルオロ-2-(トランス,トランス-4'-ペンチルビシク
ロヘキシル)-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(トランス,トランス-4'-エ
チルビシクロヘキシル)-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(トランス,トランス-4'-プ
ロピルビシクロヘキシル)-1,4-ジヒドロナフタレン 6-トリフルオロメトキシ-2-(トランス,トランス-4'-ペ
ンチルビシクロヘキシル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(トランス,
トランス-4'-エチルビシクロヘキシル)-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(トランス,
トランス-4'-プロピルビシクロヘキシル)-1,4-ジヒドロ
ナフタレン 5,7-ジフルオロ-6-トリフルオロメトキシ-2-(トランス,
トランス-4'-ペンチルビシクロヘキシル)-1,4-ジヒドロ
ナフタレンSimilarly, the following compound was obtained. 5,7-difluoro-2- (trans-4-ethylcyclohexyl)
-1,4-dihydronaphthalene 5,7-difluoro-2- (trans-4-pentylcyclohexyl) -1,4-dihydronaphthalene 5,6,7-trifluoro-2- (trans-4-ethylcyclohexyl)- 1,4-dihydronaphthalene 5,6,7-trifluoro-2- (trans-4-propylcyclohexyl) -1,4-dihydronaphthalene 5,6,7-trifluoro-2- (trans-4-pentylcyclohexyl) ) -1,4-Dihydronaphthalene 6-fluoro-2- (trans-4-ethylcyclohexyl) -1,4
-Dihydronaphthalene 6-fluoro-2- (trans-4-propylcyclohexyl)-
1,4-dihydronaphthalene 6-fluoro-2- (trans-4-pentylcyclohexyl)-
1,4-dihydronaphthalene 6-trifluoromethoxy-2- (trans-4-ethylcyclohexyl) -1,4-dihydronaphthalene 6-trifluoromethoxy-2- (trans-4-propylcyclohexyl) -1,4- Dihydronaphthalene 6-trifluoromethoxy-2- (trans-4-pentylcyclohexyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (trans-
4-Ethylcyclohexyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (trans-
4-Propylcyclohexyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (trans-
4-pentylcyclohexyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-ethylbicyclohexyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans, Trans-4'-Propylbicyclohexyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-pentylbicyclohexyl) -1,4-dihydronaphthalene 5,6,7-tri Fluoro-2- (trans, trans-4'-ethylbicyclohexyl) -1,4-dihydronaphthalene 5,6,7-trifluoro-2- (trans, trans-4'-propylbicyclohexyl) -1,4 -Dihydronaphthalene 5,6,7-trifluoro-2- (trans, trans-4'-pentylbicyclohexyl) -1,4-dihydronaphthalene 6-fluoro-2- (trans, trans-4'-ethylbicyclohexyl) ) -1,4-Dihydronaphthalene 6-fluoro-2- (trans, trans-4'-propylbicyclohexyl) -1,4-dihydronaphthalene 6-fluoro-2- (trans, trans-4'-pentylbicyclohexyl) -1,4-dihydronaphthalene 6-trifluoromethoxy-2- (trans, trans-4'-ethylbi Cyclohexyl) -1,4-dihydronaphthalene 6-trifluoromethoxy-2- (trans, trans-4'-propylbicyclohexyl) -1,4-dihydronaphthalene 6-trifluoromethoxy-2- (trans, trans-4 '-Pentylbicyclohexyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (trans,
Trans-4'-ethylbicyclohexyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (trans,
Trans-4'-propylbicyclohexyl) -1,4-dihydronaphthalene 5,7-difluoro-6-trifluoromethoxy-2- (trans,
Trans-4'-pentylbicyclohexyl) -1,4-dihydronaphthalene

【０１３１】(実施例16) 5,7-ジフルオロ-2-(トランス
-4-プロピルシクロヘキシル)-6-(3,4,5-トリフルオロフ
ェニル)-1,4-ジヒドロナフタレンの合成 実施例15で得た5,7-ジフルオロ-2-(トランス-4-プロピ
ルシクロヘキシル)-1,4-ジヒドロナフタレンから、実施
例3と同様にして5,7-ジフルオロ-2-(トランス-4-プロピ
ルシクロヘキシル)-6-(3,4,5-トリフルオロフェニル)-
1,4-ジヒドロナフタレンを得た。Example 16 5,7-Difluoro-2- (trans
Synthesis of 4- (4-propylcyclohexyl) -6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans-4-propylcyclohexyl) obtained in Example 15 ) -1,4-Dihydronaphthalene, 5,7-difluoro-2- (trans-4-propylcyclohexyl) -6- (3,4,5-trifluorophenyl) -in the same manner as in Example 3.
1,4-dihydronaphthalene was obtained.

【０１３２】同様にして以下の化合物を得た。 5,7-ジフルオロ-2-(トランス-4-エチルシクロヘキシル)
-6-(3,4,5-トリフルオロフェニル)-1,4-ジヒドロナフタ
レン 5,7-ジフルオロ-2-(トランス-4-ペンチルシクロヘキシ
ル)-6-(3,4,5-トリフルオロフェニル)-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-エチルビシ
クロヘキシル)-6-(3,4,5-トリフルオロフェニル)-1,4-
ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-プロピルビ
シクロヘキシル)-6-(3,4,5-トリフルオロフェニル)-1,4
-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-ペンチルビ
シクロヘキシル)-6-(3,4,5-トリフルオロフェニル)-1,4
-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス-4-エチルシクロヘキシル)
-6-(3,4-ジフルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス-4-プロピルシクロヘキシ
ル)-6-(3,4-ジフルオロフェニル)-1,4-ジヒドロナフタ
レン 5,7-ジフルオロ-2-(トランス-4-ペンチルシクロヘキシ
ル)-6-(3,4-ジフルオロフェニル)-1,4-ジヒドロナフタ
レン 5,7-ジフルオロ-2-(トランス,トランス-4'-エチルビシ
クロヘキシル)-6-(3,4-ジフルオロフェニル)-1,4-ジヒ
ドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-プロピルビ
シクロヘキシル)-6-(3,4-ジフルオロフェニル)-1,4-ジ
ヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-ペンチルビ
シクロヘキシル)-6-(3,4-ジフルオロフェニル)-1,4-ジ
ヒドロナフタレン 5,7-ジフルオロ-2-(トランス-4-エチルシクロヘキシル)
-6-(4-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス-4-プロピルシクロヘキシ
ル)-6-(4-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス-4-ペンチルシクロヘキシ
ル)-6-(4-フルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-エチルビシ
クロヘキシル)-6-(4-フルオロフェニル)-1,4-ジヒドロ
ナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-プロピルビ
シクロヘキシル)-6-(4-フルオロフェニル)-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-ペンチルビ
シクロヘキシル)-6-(4-フルオロフェニル)-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-2-(トランス-4-エチルシクロヘキシル)
-6-(4-トリフルオロメトキシフェニル)-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-2-(トランス-4-プロピルシクロヘキシ
ル)-6-(4-トリフルオロメトキシフェニル)-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-2-(トランス-4-ペンチルシクロヘキシ
ル)-6-(4-トリフルオロメトキシフェニル)-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-エチルビシ
クロヘキシル)-6-(4-トリフルオロメトキシフェニル)-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-プロピルビ
シクロヘキシル)-6-(4-トリフルオロメトキシフェニル)
-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-ペンチルビ
シクロヘキシル)-6-(4-トリフルオロメトキシフェニル)
-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス-4-エチルシクロヘキシル)
-6-(4-トリフルオロメトキシ-3-フルオロフェニル)-1,4
-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス-4-プロピルシクロヘキシ
ル)-6-(4-トリフルオロメトキシ-3-フルオロフェニル)-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス-4-ペンチルシクロヘキシ
ル)-6-(4-トリフルオロメトキシ-3-フルオロフェニル)-
1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-エチルビシ
クロヘキシル)-6-(4-トリフルオロメトキシ-3-フルオロ
フェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-プロピルビ
シクロヘキシル)-6-(4-トリフルオロメトキシ-3-フルオ
ロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-ペンチルビ
シクロヘキシル)-6-(4-トリフルオロメトキシ-3-フルオ
ロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス-4-エチルシクロヘキシル)
-6-(4-トリフルオロメトキシ-3,5-ジフルオロフェニル)
-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス-4-プロピルシクロヘキシ
ル)-6-(4-トリフルオロメトキシ-3,5-ジフルオロフェニ
ル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス-4-ペンチルシクロヘキシ
ル)-6-(4-トリフルオロメトキシ-3,5-ジフルオロフェニ
ル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-エチルビシ
クロヘキシル)-6-(4-トリフルオロメトキシ-3,5-ジフル
オロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-プロピルビ
シクロヘキシル)-6-(4-トリフルオロメトキシ-3,5-ジフ
ルオロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-2-(トランス,トランス-4'-ペンチルビ
シクロヘキシル)-6-(4-トリフルオロメトキシ-3,5-ジフ
ルオロフェニル)-1,4-ジヒドロナフタレンSimilarly, the following compound was obtained. 5,7-difluoro-2- (trans-4-ethylcyclohexyl)
-6- (3,4,5-Trifluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans-4-pentylcyclohexyl) -6- (3,4,5-trifluorophenyl ) -1,4-Dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-ethylbicyclohexyl) -6- (3,4,5-trifluorophenyl) -1,4-
Dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-propylbicyclohexyl) -6- (3,4,5-trifluorophenyl) -1,4
-Dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-pentylbicyclohexyl) -6- (3,4,5-trifluorophenyl) -1,4
-Dihydronaphthalene 5,7-difluoro-2- (trans-4-ethylcyclohexyl)
-6- (3,4-Difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans-4-propylcyclohexyl) -6- (3,4-difluorophenyl) -1,4- Dihydronaphthalene 5,7-difluoro-2- (trans-4-pentylcyclohexyl) -6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4 '-Ethylbicyclohexyl) -6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-propylbicyclohexyl) -6- (3, 4-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-pentylbicyclohexyl) -6- (3,4-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans-4-ethylcyclohexyl)
-6- (4-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans-4-propylcyclohexyl) -6- (4-fluorophenyl) -1,4-dihydronaphthalene 5, 7-Difluoro-2- (trans-4-pentylcyclohexyl) -6- (4-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-ethylbicyclohexyl) -6- (4-Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-propylbicyclohexyl) -6- (4-fluorophenyl) -1,4- Dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-pentylbicyclohexyl) -6- (4-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans-4 -Ethylcyclohexyl)
-6- (4-Trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans-4-propylcyclohexyl) -6- (4-trifluoromethoxyphenyl) -1,4- Dihydronaphthalene 5,7-difluoro-2- (trans-4-pentylcyclohexyl) -6- (4-trifluoromethoxyphenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4 '-Ethylbicyclohexyl) -6- (4-trifluoromethoxyphenyl)-
1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-propylbicyclohexyl) -6- (4-trifluoromethoxyphenyl)
-1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-pentylbicyclohexyl) -6- (4-trifluoromethoxyphenyl)
-1,4-dihydronaphthalene 5,7-difluoro-2- (trans-4-ethylcyclohexyl)
-6- (4-trifluoromethoxy-3-fluorophenyl) -1,4
-Dihydronaphthalene 5,7-difluoro-2- (trans-4-propylcyclohexyl) -6- (4-trifluoromethoxy-3-fluorophenyl)-
1,4-dihydronaphthalene 5,7-difluoro-2- (trans-4-pentylcyclohexyl) -6- (4-trifluoromethoxy-3-fluorophenyl)-
1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-ethylbicyclohexyl) -6- (4-trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5, 7-difluoro-2- (trans, trans-4'-propylbicyclohexyl) -6- (4-trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans , Trans-4'-pentylbicyclohexyl) -6- (4-trifluoromethoxy-3-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans-4-ethylcyclohexyl)
-6- (4-trifluoromethoxy-3,5-difluorophenyl)
-1,4-dihydronaphthalene 5,7-difluoro-2- (trans-4-propylcyclohexyl) -6- (4-trifluoromethoxy-3,5-difluorophenyl) -1,4-dihydronaphthalene 5,7 -Difluoro-2- (trans-4-pentylcyclohexyl) -6- (4-trifluoromethoxy-3,5-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans- 4'-Ethylbicyclohexyl) -6- (4-trifluoromethoxy-3,5-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4'-propylbicyclohexyl ) -6- (4-Trifluoromethoxy-3,5-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-2- (trans, trans-4′-pentylbicyclohexyl) -6- (4 -Trifluoromethoxy-3,5-difluorophenyl) -1,4-dihydronaphthalene

【０１３３】(実施例17) 5,7-ジフルオロ-6-シアノ-2-
(4-プロピルフェニル)-1,4-ジヒドロナフタレンの合成 実施例13で得た5,7-ジフルオロ-2-(4-プロピルフェニ
ル)-1,4-ジヒドロナフタレンから、実施例5と同様にし
て5,7-ジフルオロ-2-(4-プロピルフェニル)-1,4-ジヒド
ロナフタレン-6-カルボン酸を得た後、下記のようにし
て、5,7-ジフルオロ-6-シアノ-2-(4-プロピルフェニル)
-1,4-ジヒドロナフタレンを得た。Example 17 5,7-Difluoro-6-cyano-2-
Synthesis of (4-propylphenyl) -1,4-dihydronaphthalene From 5,7-difluoro-2- (4-propylphenyl) -1,4-dihydronaphthalene obtained in Example 13, in the same manner as in Example 5. After obtaining 5,7-difluoro-2- (4-propylphenyl) -1,4-dihydronaphthalene-6-carboxylic acid, 5,7-difluoro-6-cyano-2- (4-propylphenyl)
-1,4-dihydronaphthalene was obtained.

【化６４】 [Chemical 64]

【０１３４】同様にして以下の化合物を得た。 5,7-ジフルオロ-6-シアノ-2-(4-エチルフェニル)-1,4-
ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-(4-ペンチルフェニル)-1,4
-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-(4-エチル-2-フルオロフェ
ニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-(4-プロピル-2-フルオロフ
ェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-(4-ペンチル-2-フルオロフ
ェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-(4-エチル-2,6-ジフルオロ
フェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-(4-プロピル-2,6-ジフルオ
ロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-(4-ペンチル-2,6-ジフルオ
ロフェニル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-{4-(トランス-4-エチルシ
クロヘキシル)フェニル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-{4-(トランス-4-プロピル
シクロヘキシル)フェニル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-{4-(トランス-4-ペンチル
シクロヘキシル)フェニル}-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-{4-(トランス-4-エチルシ
クロヘキシル)-2-フルオロフェニル}-1,4-ジヒドロナフ
タレン 5,7-ジフルオロ-6-シアノ-2-{4-(トランス-4-プロピル
シクロヘキシル)-2-フルオロフェニル}-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-6-シアノ-2-{4-(トランス-4-ペンチル
シクロヘキシル)-2-フルオロフェニル}-1,4-ジヒドロナ
フタレン 5,7-ジフルオロ-6-シアノ-2-{4-(トランス-4-エチルシ
クロヘキシル)-2,6-ジフルオロフェニル}-1,4-ジヒドロ
ナフタレン 5,7-ジフルオロ-6-シアノ-2-{4-(トランス-4-プロピル
シクロヘキシル)-2,6-ジフルオロフェニル}-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-6-シアノ-2-{4-(トランス-4-ペンチル
シクロヘキシル)-2,6-ジフルオロフェニル}-1,4-ジヒド
ロナフタレン 5,7-ジフルオロ-6-シアノ-2-(トランス-4-エチルシクロ
ヘキシル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-(トランス-4-プロピルシク
ロヘキシル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-(トランス-4-ペンチルシク
ロヘキシル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-(トランス-4'-エチルビシ
クロヘキシル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-(トランス-4'-プロピルビ
シクロヘキシル)-1,4-ジヒドロナフタレン 5,7-ジフルオロ-6-シアノ-2-(トランス-4'-ペンチルビ
シクロヘキシル)-1,4-ジヒドロナフタレンSimilarly, the following compounds were obtained. 5,7-difluoro-6-cyano-2- (4-ethylphenyl) -1,4-
Dihydronaphthalene 5,7-difluoro-6-cyano-2- (4-pentylphenyl) -1,4
-Dihydronaphthalene 5,7-difluoro-6-cyano-2- (4-ethyl-2-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-6-cyano-2- (4-propyl-2) -Fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-6-cyano-2- (4-pentyl-2-fluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-6-cyano- 2- (4-Ethyl-2,6-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-6-cyano-2- (4-propyl-2,6-difluorophenyl) -1,4- Dihydronaphthalene 5,7-difluoro-6-cyano-2- (4-pentyl-2,6-difluorophenyl) -1,4-dihydronaphthalene 5,7-difluoro-6-cyano-2- {4- (trans -4-Ethylcyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-difluoro-6-cyano-2- {4- (trans-4-propylcyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7 -Difluoro-6-cyano-2- {4- (tran -4-Pentylcyclohexyl) phenyl} -1,4-dihydronaphthalene 5,7-difluoro-6-cyano-2- {4- (trans-4-ethylcyclohexyl) -2-fluorophenyl} -1,4-dihydro Naphthalene 5,7-difluoro-6-cyano-2- {4- (trans-4-propylcyclohexyl) -2-fluorophenyl} -1,4-dihydronaphthalene 5,7-difluoro-6-cyano-2- { 4- (trans-4-pentylcyclohexyl) -2-fluorophenyl} -1,4-dihydronaphthalene 5,7-difluoro-6-cyano-2- {4- (trans-4-ethylcyclohexyl) -2,6 -Difluorophenyl} -1,4-dihydronaphthalene 5,7-difluoro-6-cyano-2- {4- (trans-4-propylcyclohexyl) -2,6-difluorophenyl} -1,4-dihydronaphthalene 5 , 7-Difluoro-6-cyano-2- {4- (trans-4-pentylcyclohexyl) -2,6-difluorophenyl} -1,4-dihydronaphthalene 5,7-difluoro-6-si Ano-2- (trans-4-ethylcyclohexyl) -1,4-dihydronaphthalene 5,7-difluoro-6-cyano-2- (trans-4-propylcyclohexyl) -1,4-dihydronaphthalene 5,7- Difluoro-6-cyano-2- (trans-4-pentylcyclohexyl) -1,4-dihydronaphthalene 5,7-difluoro-6-cyano-2- (trans-4'-ethylbicyclohexyl) -1,4- Dihydronaphthalene 5,7-difluoro-6-cyano-2- (trans-4'-propylbicyclohexyl) -1,4-dihydronaphthalene 5,7-difluoro-6-cyano-2- (trans-4'-pliers Rubicyclohexyl) -1,4-dihydronaphthalene

【０１３５】(実施例18) 液晶組成物の調製 温度範囲が広く低粘性でアクティブマトリックス駆動に
も使用可能な汎用のホスト液晶(H)(Example 18) A general-purpose host liquid crystal (H) having a wide preparation temperature range of a liquid crystal composition, low viscosity, and usable for active matrix driving

【化６５】 を調製した。この(H)は116.7℃以下でネマチック相を示
し、その融点は＋11℃である。この組成物の物性値なら
びに、これを用いて作成したTNセル(セル厚6μm)の20℃
における電気光学的特性の測定値は以下の通りであっ
た。 閾値電圧(Vth)： 2.14V 誘電率異方性(Δε)： 4.8 レスポンス(τr=τd)： 25.3m秒 屈折率異方性(Δn)： 0.090 ここで、レスポンスは立ち上がり時間(τr)と立ち下が
り時間(τd)とが等しくなる電圧印加時の測定値であ
る。[Chemical 65] Was prepared. This (H) shows a nematic phase below 116.7 ° C, and its melting point is + 11 ° C. Physical properties of this composition and TN cell (cell thickness 6 μm) prepared using this composition at 20 ° C.
The measured values of the electro-optical characteristics in Table 1 were as follows. Threshold voltage (Vth): 2.14V Dielectric anisotropy (Δε): 4.8 Response (τr = τd): 25.3msec Refractive index anisotropy (Δn): 0.090 where the response is the rise time (τr) It is a measured value when a voltage is applied so that the fall time (τd) becomes equal.

【０１３６】次にこのホスト液晶(H)の80％と実施例3で
得られた下記の5,7-ジフルオロ-2-プロピル-6-(3,4,5-
トリフルオロフェニル)-1,4-ジヒドロナフタレンNext, 80% of this host liquid crystal (H) and the following 5,7-difluoro-2-propyl-6- (3,4,5-
Trifluorophenyl) -1,4-dihydronaphthalene

【化６６】 20％からなる液晶組成物(M-1)を調製したところ、ネマ
チック相上限温度(TN-I)は77.4℃であった。[Chemical formula 66] When a liquid crystal composition (M-1) containing 20% was prepared, the maximum temperature of the nematic phase (T NI ) was 77.4 ° C.

【０１３７】次に、(M-1)をセル厚6.0μmのTNセルに充
填して液晶素子を作成し、その電気光学特性を測定した
ところ、以下の通りであった。 閾値電圧(Vth)： 1.30V 誘電率異方性(Δε)： 7.5 レスポンス(τr=τd)： 41.4m秒 屈折率異方性(Δn)： 0.094 従って、5,7-ジフルオロ-2-プロピル-6-(3,4,5-トリフ
ルオロフェニル)-1,4-ジヒドロナフタレンを20％添加す
ることにより、レスポンスも16.1m秒の増加に抑えなが
ら、誘電率異方性を増大させ閾値電圧(Vth)を0.84Vも低
減することができた。Next, (M-1) was filled in a TN cell having a cell thickness of 6.0 μm to prepare a liquid crystal element, and its electro-optical characteristics were measured. Threshold voltage (Vth): 1.30V Dielectric anisotropy (Δε): 7.5 Response (τr = τd): 41.4 ms Refractive index anisotropy (Δn): 0.094 Therefore, 5,7-difluoro-2-propyl- By adding 20% of 6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene, while increasing the response to 16.1 msec, the dielectric anisotropy was increased and the threshold voltage ( Vth) could be reduced by 0.84V.

【０１３８】(比較例1)実施例18において、5,7-ジフル
オロ-2-プロピル-6-(3,4,5-トリフルオロフェニル)-1,4
-ジヒドロナフタレンに換えて、下記の5,7-ジフルオロ-
6-(3,4,5-トリフルオロフェニル)-2-プロピル-1,2,3,4-
テトラヒドロナフタレンComparative Example 1 In Example 18, 5,7-difluoro-2-propyl-6- (3,4,5-trifluorophenyl) -1,4
-In place of dihydronaphthalene, the following 5,7-difluoro-
6- (3,4,5-trifluorophenyl) -2-propyl-1,2,3,4-
Tetrahydronaphthalene

【化６７】 を(H)に同量(20％)添加して液晶組成物(M-2)を調製し
た。ネマチック相上限温度(TN-I)は76.4℃であった。[Chemical formula 67] Was added to (H) in the same amount (20%) to prepare a liquid crystal composition (M-2). The maximum temperature of the nematic phase (TN-I) was 76.4 ° C.

【０１３９】次に、(M-2)をセル厚6.0μmのTNセルに充
填して液晶素子を作成し、その電気光学特性を測定した
ところ、以下の通りであった。 閾値電圧(Vth)： 1.36V 誘電率異方性(Δε)： 7.4 レスポンス(τr=τd)： 44.4m秒 屈折率異方性(Δn)： 0.089 実施例18に示した化合物と比べ、レスポンスが悪く、誘
電率異方性が小さく、閾値電圧の低減効果も小さい。さ
らに、ネマチック相上限温度も低く、液晶性に劣ること
が判る。Next, (M-2) was filled in a TN cell having a cell thickness of 6.0 μm to prepare a liquid crystal element, and its electro-optical characteristics were measured. The results were as follows. Threshold voltage (Vth): 1.36V Dielectric anisotropy (Δε): 7.4 Response (τr = τd): 44.4 ms Refractive index anisotropy (Δn): 0.089 Compared with the compound shown in Example 18, the response was Poor, the dielectric anisotropy is small, and the effect of reducing the threshold voltage is also small. Furthermore, it is understood that the maximum temperature of the nematic phase is low and the liquid crystallinity is poor.

【０１４０】(実施例19) 液晶組成物の調製 以下の組成からなるホスト液晶組成物(H')Example 19 Preparation of Liquid Crystal Composition Host liquid crystal composition (H ') having the following composition

【０１４１】[0141]

【化６８】 [Chemical 68]

【０１４２】を調製した。ここで(H')の物性値は以下の
通りである。 ネマチック相上限温度(TN-I) 75.0℃ 固体相又はスメクチック相-ネマチック相転移温度(T→
N) -70℃ 閾値電圧(Vth) 1.49V 誘電率異方性(Δε) 10.3 屈折率異方性(Δn) 0.142Was prepared. Here, the physical property values of (H ') are as follows. Maximum temperature of nematic phase (TN-I) 75.0 ℃ Solid phase or smectic phase-nematic phase transition temperature (T →
N) -70 ℃ Threshold voltage (Vth) 1.49V Dielectric anisotropy (Δε) 10.3 Refractive index anisotropy (Δn) 0.142

【０１４３】この母体液晶(H')90％と実施例3で得られ
た5,7-ジフルオロ-2-プロピル-6-(3,4,5-トリフルオロ
フェニル)-1,4-ジヒドロナフタレン10％からなる液晶組
成物(M-3)を調製した。この組成物の物性値は以下の通
りである。 ネマチック相上限温度(TN-I) 69.5℃ 固体相又はスメクチック相-ネマチック相転移温度(T→
N) -70℃ 閾値電圧(Vth) 1.23V 誘電率異方性(Δε) 11.7 屈折率異方性(Δn) 0.14090% of this host liquid crystal (H ′) and 5,7-difluoro-2-propyl-6- (3,4,5-trifluorophenyl) -1,4-dihydronaphthalene obtained in Example 3 A liquid crystal composition (M-3) consisting of 10% was prepared. The physical properties of this composition are as follows. Maximum temperature of nematic phase (TN-I) 69.5 ℃ Solid phase or smectic phase-nematic phase transition temperature (T →
N) -70 ℃ Threshold voltage (Vth) 1.23V Dielectric anisotropy (Δε) 11.7 Refractive index anisotropy (Δn) 0.140

【０１４４】[0144]

【発明の効果】本発明のジヒドロナフタレン化合物は液
晶組成物の構成材料として用いた場合、表示素子のレス
ポンスを改善あるいは悪化させることなく、閾値電圧を
下げる効果を有する。従って、動画に対応した高速表示
液晶ディスプレイ用の材料として優れ、さらに、閾値電
圧を下げる効果を有することから液晶ディスプレイの省
電力化に大きな効果を有する。When the dihydronaphthalene compound of the present invention is used as a constituent material of a liquid crystal composition, it has the effect of lowering the threshold voltage without improving or deteriorating the response of the display device. Therefore, it is excellent as a material for a high-speed display liquid crystal display corresponding to a moving image, and further, has an effect of lowering a threshold voltage, and thus has a great effect on power saving of the liquid crystal display.

───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ｃ０９Ｋ 19/32 Ｃ０９Ｋ 19/32 19/34 19/34 Ｇ０２Ｆ 1/13 ５００ Ｇ０２Ｆ 1/13 ５００ Ｆターム(参考） 4H006 AA01 AA03 AB64 BJ50 BM30 BM71 EA39 EA40 KC30 4H027 BA01 BC04 BD02 BD05 BD07 BD08 BD09 CB01 CB02 CC04 CD04 CL01 CL04 CM01 CM04 CN04 CP04 CQ01 CQ04 CR04 CT02 CT04 CW01 CW02 DE04 DM05 ─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. 7 Identification code FI theme code (reference) C09K 19/32 C09K 19/32 19/34 19/34 G02F 1/13 500 G02F 1/13 500 F term ( Reference) 4H006 AA01 AA03 AB64 BJ50 BM30 BM71 EA39 EA40 KC30 4H027 BA01 BC04 BD02 BD05 BD07 BD08 BD09 CB01 CB02 CC04 CD04 CL01 CL04 CM01 CM04 CN04 CP04 CQ01 CQ04 CR04 CT02 CT04 CW01 CW02 DE04 DM05

Claims (18)

【特許請求の範囲】[Claims] 【請求項１】 一般式(I) 【化１】 (式中、Rは炭素原子数1〜20のアルキル基、炭素原子数1
〜20のアルコキシル基、炭素原子数2〜20のアルケニル
基又は炭素原子数2〜20のアルケニルオキシ基を表しこ
れらは炭素原子数1〜7のアルコキシル基又は1〜7個のハ
ロゲン原子によって置換されていてもよく、m、n、q、t
はそれぞれ独立に0又は1を表し、A、B、C及びDはそれぞ
れ独立にトランス-1,4-シクロへキシレン基、トランス,
トランス-ビシクロヘキサン-4,4'-ジイル基、ビシクロ
[2.2.2]オクタン-1,4-ジイル基、又は1個以上のハロゲ
ン原子により置換されていてもよい、1,4-フェニレン
基、ピリジン-2,5-ジイル基、ピリミジン-2,5-ジイル
基、ピラジン-2,5-ジイル基、ピリダジン-3,6-ジイル
基、トランス-1,3-ジオキサン-2,5-ジイル基、トランス
デカヒドロナフタレン-2,6-ジイル基、テトラヒドロナ
フタレン-2,6-ジイル基、ナフタレン-2,6-ジイル基を表
し、L、M、Q、Tはそれぞれ独立に-CH2CH2-、-CH2CH2CH 2
CH2-、-CH=CH-、-CH=CHCH2CH2-、-CH2CH2CH=CH-、-CH(C
H3)CH2-、-CH2CH(CH3)-、-CF=CF-、-CH2O-、-OCH2-、-C
F2O-、-OCF2-、-COO-、-OCO-、-C≡C-又は単結合を表
し、X1及びX2は塩素原子又はフッ素原子を表し、Zは、
水素原子、ハロゲン原子、シアノ基、シアナト基、-SC
N、又は、1個以上のフッ素原子によって置換されていて
もよい炭素原子数1〜20のアルキル基、アルコキシル
基、アルケニル基、アルケニルオキシ基を表す。)で表
されるジヒドロナフタレン誘導体。1. The general formula (I) [Chemical 1] (Wherein, R is an alkyl group having 1 to 20 carbon atoms, 1 carbon atom
~ 20 alkoxyl groups, alkenyl with 2-20 carbon atoms
Represents a group or an alkenyloxy group having 2 to 20 carbon atoms.
These are alkoxyl groups having 1 to 7 carbon atoms or 1 to 7
May be substituted by a rogen atom, m, n, q, t
Each independently represent 0 or 1, and A, B, C and D are each
Independently, trans-1,4-cyclohexylene group, trans,
Trans-bicyclohexane-4,4'-diyl group, bicyclo
[2.2.2] Octane-1,4-diyl group, or one or more halogen
1,4-phenylene, which may be substituted by a hydrogen atom
Group, pyridine-2,5-diyl group, pyrimidine-2,5-diyl
Group, pyrazine-2,5-diyl group, pyridazine-3,6-diyl
Group, trans-1,3-dioxane-2,5-diyl group, trans
Decahydronaphthalene-2,6-diyl group, tetrahydrona
Represents phthalene-2,6-diyl group and naphthalene-2,6-diyl group
, L, M, Q, T are independently -CH2CH2-, -CH2CH2CH 2
CH2-, -CH = CH-, -CH = CHCH2CH2-, -CH2CH2CH = CH-, -CH (C
H3) CH2-, -CH2CH (CH3)-, -CF = CF-, -CH2O-, -OCH2-, -C
F2O-, -OCF2-, -COO-, -OCO-, -C≡C- or represents a single bond
Then X1And X2Represents a chlorine atom or a fluorine atom, and Z is
Hydrogen atom, halogen atom, cyano group, cyanato group, -SC
N, or substituted by one or more fluorine atoms
Good alkyl group having 1 to 20 carbon atoms, alkoxyl
Represents a group, an alkenyl group and an alkenyloxy group. )
Dihydronaphthalene derivative. 【請求項２】 一般式(I)において、X1がフッ素原子を
表す請求項1記載の化合物。2. The compound according to claim 1 , wherein in the general formula (I), X 1 represents a fluorine atom. 【請求項３】 一般式(I)において、X2がフッ素原子を
表す請求項1記載の化合物。3. The compound according to claim 1, wherein in the general formula (I), X 2 represents a fluorine atom. 【請求項４】 一般式(I)において、X1及びX2がフッ素
原子を表す請求項1記載の化合物。4. The compound according to claim 1 , wherein X 1 and X 2 in the general formula (I) represent a fluorine atom. 【請求項５】 一般式(I)において、Zがフッ素原子、炭
素原子数2〜7のアルケニルオキシ基、一個以上のフッ素
原子によって置換された炭素原子数1〜7のアルキル基、
一個以上のフッ素原子によって置換された炭素原子数1
〜7のアルコキシル基又は一個以上のフッ素原子によっ
て置換された炭素原子数1〜7のアルケニル基を表す請求
項1〜4の何れかに記載の化合物。5. In the general formula (I), Z is a fluorine atom, an alkenyloxy group having 2 to 7 carbon atoms, an alkyl group having 1 to 7 carbon atoms substituted by one or more fluorine atoms,
1 carbon atom substituted by one or more fluorine atoms
5. The compound according to any one of claims 1 to 4, which represents an alkoxyl group of 7 to 7 or an alkenyl group having 1 to 7 carbon atoms which is substituted with one or more fluorine atoms. 【請求項６】 一般式(I)において、Zがフッ素原子、フ
ルオロメトキシ基、ジフルオロメトキシ基、トリフルオ
ロメトキシ基、フルオロメチル基、ジフルオロメチル
基、トリフルオロメチル基又はシアノ基を表す請求項1
〜4の何れかに記載の化合物。6. In the general formula (I), Z represents a fluorine atom, a fluoromethoxy group, a difluoromethoxy group, a trifluoromethoxy group, a fluoromethyl group, a difluoromethyl group, a trifluoromethyl group or a cyano group.
5. The compound according to any one of 4 to 4. 【請求項７】 一般式(I)において、Dが1個以上のハロ
ゲン原子により置換されていてもよい1,4-フェニレン基
を表す請求項1〜6の何れかに記載の化合物。7. The compound according to any one of claims 1 to 6, wherein in the general formula (I), D represents a 1,4-phenylene group optionally substituted by one or more halogen atoms. 【請求項８】 一般式(I)において、Dが一個以上のフッ
素原子によって置換された1,4-フェニレン基を表す請求
項1〜6の何れかに記載の化合物。8. The compound according to claim 1, wherein in the general formula (I), D represents a 1,4-phenylene group substituted by one or more fluorine atoms. 【請求項９】 一般式(I)において、Tが-CH2CH2-、-CF=
CF-、-CF2O-、-OCF2-、-C≡C-又は単結合を表す請求項1
〜8の何れかに記載の化合物。9. In the general formula (I), T is —CH 2 CH 2 —, —CF =
CF-, -CF 2 O-, -OCF 2- , -C≡C- or a single bond.
9. The compound according to any one of to 8. 【請求項１０】 一般式(I)において、Lが-CH2CH2-、-C
F=CF-、-CF2O-、-OCF2-、-C≡C-又は単結合を表す請求
項1〜9の何れかに記載の化合物。10. In the general formula (I), L is —CH 2 CH 2 —, —C.
F = CF -, - CF 2 O -, - OCF 2 -, - C≡C- or a compound according to any one of claims 1 to 9 represents a single bond. 【請求項１１】 一般式(I)において、Rが炭素原子数1
〜7の直鎖アルキル基又は炭素原子数1〜7の直鎖アルコ
キシル基を表す請求項1〜9の何れかに記載の化合物。11. In the general formula (I), R is 1 carbon atom.
10. The compound according to any one of claims 1 to 9, which represents a straight-chain alkyl group having 7 to 7 or a straight-chain alkoxyl group having 1 to 7 carbon atoms. 【請求項１２】 一般式(I)において、Rが炭素原子数1
〜7の直鎖アルキル基又は炭素原子数1〜7の直鎖アルコ
キシル基を表し、m = n = q = 0かつt = 1を表し、X1及
びX2の少なくとも一つがフッ素原子を表し、Tが単結合
又は-C≡C-を表し、Dが一個以上のフッ素原子によって
置換されていてもよい1,4-フェニレン基を表す請求項1
記載の化合物。12. In the general formula (I), R has 1 carbon atom.
~ 7 represents a linear alkyl group or a linear alkoxyl group having 1 to 7 carbon atoms, m = n = q = 0 and t = 1, at least one of X 1 and X 2 represents a fluorine atom, T represents a single bond or -C≡C-, and D represents a 1,4-phenylene group optionally substituted by one or more fluorine atoms.
The described compound. 【請求項１３】 一般式(I)において、Rが炭素原子数1
〜7の直鎖アルキル基又は炭素原子数1〜7の直鎖アルコ
キシル基を表し、m = 1かつn = q = t = 0を表し、X1及
びX2の少なくとも一つがフッ素原子を表し、Lが単結合
又は-CH2CH2-を表し、Aがトランス-1,4-シクロヘキシレ
ン基又はトランス,トランス-1,1'-ビシクロヘキサン-4,
4'-ジイル基を表す請求項1記載の化合物。13. In the general formula (I), R is 1 carbon atom.
~ 7 represents a linear alkyl group or a linear alkoxyl group having 1 to 7 carbon atoms, m = 1 and n = q = t = 0, at least one of X 1 and X 2 represents a fluorine atom, L represents a single bond or -CH 2 CH 2- , A is trans-1,4-cyclohexylene group or trans, trans-1,1'-bicyclohexane-4,
The compound according to claim 1, which represents a 4'-diyl group. 【請求項１４】 一般式(I)において、Rが炭素原子数1
〜7の直鎖アルキル基又は炭素原子数1〜7の直鎖アルコ
キシル基を表し、m = t = 1かつn = q = 0を表し、X1及
びX2の少なくとも一つがフッ素原子を表し、Lが単結合
又は-CH2CH2-を表し、Tが単結合又は-C≡C-を表し、Aが
トランス-1,4-シクロヘキシレン基又はトランス,トラン
ス-1,1'-ビシクロヘキサン-4,4'-ジイル基を表し、Dが
一個以上のフッ素原子によって置換されていてもよい1,
4-フェニレン基を表す請求項1記載の化合物。14. In the general formula (I), R is 1 carbon atom.
~ 7 represents a linear alkyl group or a linear alkoxyl group having 1 to 7 carbon atoms, m = t = 1 and n = q = 0, at least one of X 1 and X 2 represents a fluorine atom, L represents a single bond or -CH 2 CH 2- , T represents a single bond or -C≡C-, and A represents a trans-1,4-cyclohexylene group or trans, trans-1,1'-bicyclohexane. -4,4'-diyl group is represented, D may be substituted by one or more fluorine atoms 1,
The compound according to claim 1, which represents a 4-phenylene group. 【請求項１５】 請求項1記載の一般式(I)で表される化
合物を含有する液晶組成物。15. A liquid crystal composition containing the compound represented by the general formula (I) according to claim 1. 【請求項１６】 アクティブマトリックス駆動用に用い
られる請求項15記載の液晶組成物。16. The liquid crystal composition according to claim 15, which is used for driving an active matrix. 【請求項１７】 請求項15記載の液晶組成物を構成要素
とする液晶表示素子。17. A liquid crystal display device comprising the liquid crystal composition according to claim 15 as a constituent element. 【請求項１８】 請求項15記載の液晶組成物を用いたア
クティブマトリックス駆動液晶表示素子。 【発明の属する技術分野】本発明は電気光学的液晶表示
材料として有用な、ジヒドロナフタレン誘導体である新
規液晶性化合物とそれを含む液晶組成物及びそれを用い
た液晶表示素子に関する。18. An active matrix driven liquid crystal display device using the liquid crystal composition according to claim 15. TECHNICAL FIELD The present invention relates to a novel liquid crystalline compound which is a dihydronaphthalene derivative useful as an electro-optical liquid crystal display material, a liquid crystal composition containing the same, and a liquid crystal display device using the same.
JP2001301171A 2001-09-28 2001-09-28 Dihydronaphthalene derivative, liquid crystal composition containing the same, and liquid crystal display device Expired - Fee Related JP4844785B2 (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001011459A (en) * 1999-06-30 2001-01-16 Dainippon Ink & Chem Inc Liquid crystal medium and liquid crystal display element containing the liquid crystal medium
JP2001181637A (en) * 1999-12-27 2001-07-03 Dainippon Ink & Chem Inc Liquid crystal medium
JP2001192659A (en) * 2000-01-13 2001-07-17 Dainippon Ink & Chem Inc Liquid crystal composition
JP2003146919A (en) * 2001-08-30 2003-05-21 Dainippon Ink & Chem Inc Dihydronaphthalene derivative, and liquid crystal composition and liquid crystal display element containing the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001011459A (en) * 1999-06-30 2001-01-16 Dainippon Ink & Chem Inc Liquid crystal medium and liquid crystal display element containing the liquid crystal medium
JP2001181637A (en) * 1999-12-27 2001-07-03 Dainippon Ink & Chem Inc Liquid crystal medium
JP2001192659A (en) * 2000-01-13 2001-07-17 Dainippon Ink & Chem Inc Liquid crystal composition
JP2003146919A (en) * 2001-08-30 2003-05-21 Dainippon Ink & Chem Inc Dihydronaphthalene derivative, and liquid crystal composition and liquid crystal display element containing the same

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