JP2003095982A - Improver for feeling on tongue of sorbitol tablet molding - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an improver for feeling on the tongue of a sorbitol tablet molding, with which, in the case of obtaining sorbitol tablet molding, tablet molding having excellent color and luster on the surface of obtained tablet, uniform and dense structure of the whole tablet from the surface to the inside of the tablet and no roughness and smooth melting in the oral cavity free from roughness can be obtained. SOLUTION: This improver for feeling on the tongue of the sorbitol tablet molding comprises sucrose behenic acid ester as an active ingredient. The sucrose behenic acid ester is usually used in the ratio of 0.5-3 wt.% based on the whole sorbitol tablet molding.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a texture-improving agent for sorbitol tablet-formed products. By using the texture improver of the present invention in the production of pharmaceutical tablets or tablet confections containing sorbitol, the color and gloss of the tablet surface is good, and the entire tablet from the surface to the inside of the tablet has a uniform and dense structure. Thus, it is possible to obtain a tablet-formed product which is free from roughness and melts smoothly in the oral cavity.

[0002]

2. Description of the Related Art Conventionally, in the production of tablets (including tablet confectionery), it is possible to prevent the raw material powder from consolidating and improve the fluidity to improve the filling property in a tablet making machine and to improve the tablet surface. It has been proposed to use sucrose fatty acid esters of HLB2 to 3 as a lubricant for imparting luster to the eyes (Japanese Patent Laid-Open No. 49-7421).
JP-A-55-360 and the like). It has also been proposed that the yield of products is improved by using a spherical sucrose fatty acid ester having an average particle diameter of 30 μm or less (Japanese Patent Laid-Open No. 10-139688).

Starch and saccharides have been conventionally used as excipients or sweetening agents in raw material powders for tablets. By the way, in recent years, various sugar alcohols have been marketed as sweeteners with excellent taste, and tablets that rapidly disintegrate in the oral cavity, or as excipients such as chewable tablets that enjoy the texture in the oral cavity are also available. , The use of sugar alcohol is increasing. However, in recent years, due to the spread of diet foods,
Sugar alcohols with low calories and excellent taste are used as excipients such as tablets that rapidly disintegrate in the oral cavity and chewable tablets that enjoy the texture in the oral cavity. Therefore, even if sorbitol, maltitol, etc., which are hygroscopic sugar alcohols, are used, sucrose fatty acid ester having a melting start point of 50 ° C or higher can be directly tableted without sticking to the tableting machine. A tablet composition using the above has been proposed (Japanese Patent Laid-Open No. 20-200200).
00-264835).

Among the hygroscopic sugar alcohols, sorbitol has a large weight increase due to moisture absorption as the humidity becomes higher,
For example, at room temperature (24 ° C.), the relative humidity is 75%, and the weight increase at 24 hours is about 5% by weight. Therefore, in the case of a sorbitol tableting molded article, in addition to the problem that it is difficult to adhere to a tableting machine and direct tableting, coarse crystals of sorbitol are easily generated during tableting, and the gloss of the obtained tablet surface is lost, and , The tablets do not feel well in the oral cavity and often feel rough.

On the other hand, when tableting a raw material powder containing a component such as vitamin C which is easily altered, the number of carbon atoms is 1
Using a sucrose fatty acid ester having a saturated fatty acid of 6 to 22 as a constituent fatty acid and an acid value of 3 or less, a tablet resulting from deterioration of the lubricant during storage and reaction between the lubricant and the powder component There is also proposed a composition for tablets, which is used to obtain a product which is excellent in storage stability, in which deterioration is suppressed, coloration and off-flavors are suppressed (Japanese Patent Laid-Open No. 2000-321589).

[0006]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and an object thereof is to obtain a sorbitol tableting molded article having a good color and gloss on the tablet surface,
Further, the present invention provides a texture improving agent for sorbitol tablet-molded articles, which enables to obtain tablet-molded articles having a uniform and dense structure from the surface of the tablet to the inside thereof, which is smooth and melts smoothly in the oral cavity. Especially.

[0007]

That is, the gist of the present invention resides in a texture improving agent for sorbitol tablet-molded articles containing sucrose behenate as an active ingredient.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail below.
The texture-improving agent for sorbitol tablet-formed products according to the present invention is suitably used for tablet-formed products containing 80% by weight or more, preferably 95% by weight or more of sorbitol as a raw material powder used for tablets. . As such a raw material powder, in addition to sorbitol, various powders generally used as an excipient or a sweetening ingredient can be used. Examples thereof include other sugar alcohols such as erythritol, and high-intensity sweeteners such as aspartame, stevia, sucralose, and acesulfame K. As the sorbitol, a commercially available product containing no fine powder can be used as it is, and a commercially available product for direct hitting which is particularly spherical and has excellent fluidity is preferable.

The texture-improving agent for sorbitol tablet-formed products according to the present invention contains sucrose behenate as an active ingredient. As the sucrose behenic acid ester, those in which the proportion of behenic acid in the constituent fatty acids is about 70% by weight or more and the average degree of esterification is 1.8 to 5 are preferable, and particularly the average degree of esterification is 2 to 4 Therefore, sucrose behenate, which is a powder mainly composed of pulverized products, is preferable. Also, the particle size is 20 μm
When sucrose behenic acid ester containing 50% by weight or more of the following finely pulverized products is used, not only the effect of improving the texture of the sorbitol tableting molded product but also the use of no other lubricant, It is particularly preferable because the fluidity of the powder is improved, the powder is uniformly filled, and the powder is uniformly compression-molded.

The amount of the texture-improving agent used in the sorbitol tablet-molded product according to the present invention is usually 0.5 to 3% by weight, preferably 0.5 to 2 based on the total amount of the sorbitol tablet-molded product.
% By weight. In particular, 5 finely pulverized products with a particle size of 20 μm or less
When using sucrose behenic acid ester that is contained in an amount of 0% by weight or more, a sufficient effect is often obtained when the amount used is about 1.5% by weight.

The sorbitol tablet-molded articles to which the texture-improving agent of the present invention is applied include the above-mentioned raw material powder used as an excipient or a sweetening ingredient, and various powders usually used for tablets. The ingredients can be used. Examples thereof include acidulants such as citric acid, flavors, various functional components such as vitamins and minerals, and pharmaceutical powders containing various medicinal components.

In order to produce pharmaceutical tablets, tablet confections and the like containing sorbitol using the texture-improving agent of the present invention, a raw material composition obtained by mixing powder components at a predetermined ratio is usually used. A tablet can be obtained by processing with a tableting machine according to a standard method. The shape of the tablet is not particularly limited, and may be, for example, a round shape, a flat plate, a triangular shape, or any shape depending on the purpose, and the size thereof may be appropriately selected.

[0013]

EXAMPLES The present invention will be described in more detail with reference to examples below, but the present invention is not limited to the following examples as long as the gist thereof is not exceeded. The raw material powders shown in Table 1 were used in the following examples.

[0014]

[Table 1]

Example 1 and Comparative Example 1 Sorbitol formulation shown in Table 2 (% by weight relative to the whole)
3 kg of a raw material powder mixture (16 mesh PASS) prepared by powder-powdering the sucrose fatty acid ester of 1. was prepared, and the whole amount was charged using a tableting machine (“HP-15” manufactured by Hata Tekko Co., Ltd.), Speed 20 rpm / min. , Tableting pressure 1.0T
Round tablet (dosage form; diameter 9 mm x thickness 5 mm, 300
mg) tableting test was performed (tableting time 40 minutes). In addition,
The temperature at the time of tableting is 22.7 to 24.5 ° C, and the humidity is 34.0.
Was about 38.0%. The results are shown in Table 2. "○" indicates that the entire amount was compressed without sticking during tableting.
And

[0016]

[Table 2]

The hardness (kg) and the tablet water content (% by weight) were measured for two cases in which the entire amount of the charged material could be compressed into tablets. A Kiya type digital hardness tester ("KHT-20" manufactured by Fujiwara Seisakusho) is used to measure the hardness, and an electronic moisture meter ("LIBROR" manufactured by Shimadzu) is used to measure the tablet water content.
EB-280MOC ") was used. The appearance and texture of the tablets obtained in the same example were sensory-evaluated by 10 evaluators based on the evaluation criteria shown in Table 3. The results are shown in Table 4.
Shown in.

[0018]

[Table 3]

[0019]

[Table 4]

[0020]

EFFECTS OF THE INVENTION According to the present invention, there is provided a tablet-molded article having a good color and gloss on the tablet surface and having a uniform and dense structure throughout the tablet from the surface of the tablet to the inside thereof, which is smooth and does not melt in the mouth. You can get it.

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Claims (3)

[Claims] 1. A texture improving agent for a sorbitol tablet-molded article, which comprises sucrose behenate as an active ingredient. 2. The texture improver according to claim 1, wherein the sucrose behenate has an average degree of esterification of 1.8 to 5. 3. The texture improver according to claim 1, wherein the sucrose behenate is used in an amount of 0.5 to 3% by weight based on the entire sorbitol tablet-formed product.