JP2003093410A - Denture fixing agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a denture fixing agent capable of significantly preventing generation of the oil float, separation, syneresis, etc., when stored caused by the influence of vibrations, heat, etc., and excellent in the stability with the elapsed time, and a denture fixing agent with the excellent adhesive force and sustainability of the adhesiveness added to the denture fixing agent. SOLUTION: The denture fixing agent including the gelatinized hydrocarbon or the mixture of the gelatinized hydrocarbon and Vaseline, the denture fixing agent with cellulose derivatives and their salts mixed in the denture fixing agent, and the denture fixing agent with a lower alkylvinyl ether/maleic anhydride copolymer and the derivatives further mixed in the denture fixing agent are provided.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a denture stabilizer. More specifically, the present invention relates to a denture stabilizer excellent in storage stability, particularly heat stability. Furthermore, the present invention relates to a denture stabilizer that continuously exhibits adhesive force when applied to the oral cavity.

[0002]

2. Description of the Related Art Conventionally, a non-aqueous composition in which a water-soluble polymer such as carboxymethyl cellulose or polyethylene oxide is dispersed in a mineral oil component such as petrolatum or paraffin has been widely used as a denture stabilizer. Such a non-aqueous denture stabilizer swells when the water-soluble polymer in the agent comes into contact with saliva, so that the ridge and the denture are brought into close contact with each other,
The denture is fixed by using its adhesiveness.

However, the mineral oil used as a base component in a non-aqueous denture stabilizer is susceptible to vibration, heat, etc., and oil floating, separation (sedimentation), syneresis, etc. are likely to occur. Therefore, there is a problem that the stability of the non-aqueous denture stabilizer is poor.

Furthermore, when a non-aqueous denture stabilizer is applied to the oral cavity, the water-soluble polymer dispersed in mineral oil is dissolved in saliva, and as a result, the adhesiveness of the denture stabilizer increases with the lapse of use time. However, there is a drawback in that the feeling of use and the feeling of use deteriorate as a result.

Against the background of such conventional techniques, there has been a demand for the development of a denture stabilizer which is excellent in stability over time and which can maintain adhesive strength.

[0006]

SUMMARY OF THE INVENTION The present invention is directed to overcoming the above-mentioned conventional problems associated with denture stabilizers. More specifically, the present invention firstly provides a denture stabilizer in which the occurrence of oil floating, separation (sedimentation), syneresis, etc. during storage that can occur due to the effects of vibration, heat, etc. is significantly prevented. The purpose is. Second,
It is an object of the present invention to provide a denture stabilizer capable of absorbing moisture in the oral cavity and continuously exerting adhesiveness when applied to the oral cavity.

[0007]

Means for Solving the Problems The inventors of the present invention have made extensive studies to achieve the above-mentioned object. As a result, the use of gelled hydrocarbon or a mixture of gelled hydrocarbon and petrolatum as a base material. It was found that the improved stability can significantly solve the problems of oil floating during storage, separation or syneresis. Further, by exhibiting excellent adhesive force in the oral cavity by blending carboxymethyl cellulose to such a base material, and by further blending this with a lower alkyl vinyl ether / maleic anhydride copolymer, It was found that the adhesive strength in the remarkably lasts. The present invention has been completed based on such findings. That is, the present invention is the denture stabilizer listed below: Item 1. Denture stabilizer containing gelled hydrocarbon or a mixture of gelled hydrocarbon and petrolatum as a base material. Item 2. Item 10. The denture stabilizer according to Item 1, further containing at least one selected from the group consisting of cellulose derivatives and salts thereof. Item 3. Item 3. The denture stabilizer according to Item 2, wherein the cellulose derivative is carboxymethyl cellulose. Item 4. The denture stabilizer according to any one of items 1 to 3, further containing a lower alkyl vinyl ether / maleic anhydride copolymer and a derivative thereof.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The denture stabilizer of the present invention is characterized by containing gelled hydrocarbon or a mixture of gelled hydrocarbon and petrolatum as a base material.

The gelled hydrocarbon used in the present invention is
It is a gel-like product made by mixing polyethylene with liquid paraffin. Specifically, 100 parts by weight of liquid paraffin and 5
A gel-like material composed of 10 to 10 parts by weight of polyethylene can be exemplified.

Here, examples of the liquid paraffin include light liquid paraffin and heavy liquid paraffin. In the present invention, liquid paraffin having a carbon number of 16 to 36 can be preferably used.

On the other hand, the polyethylene which forms a gel with the above liquid paraffin usually has a number average molecular weight in the range of 1,000 to 50,000, preferably 1,000.
The thing in the range of 0-30000 can be illustrated. Polyethylene in such a range is usually solid at 25 ° C and has a melting point in the range of 37.5 to 145 ° C.

The gelled hydrocarbon is not particularly limited, but is usually 5 to 10 parts by weight of polyethylene, preferably 5.5 parts by weight with respect to 100 parts by weight of the liquid paraffin.
It can be prepared as a gel-like material by blending in a proportion of ˜7.5 parts by weight and heating and mixing at a temperature at which polyethylene melts, specifically at a temperature in the range of 110˜130 ° C.

Such gelled hydrocarbons are commercially available under the trade names of Plastibase (Bristol-Myers Squibb Company) and trade names of POLOID (Maruishi Pharmaceutical Co., Ltd.). It is also possible to use such commercially available products.

The gelling hydrocarbon content per 100 parts by weight of the denture stabilizer of the present invention is usually 10 to 70 parts by weight, preferably 10 to 50 parts by weight, more preferably 1 part by weight.
The proportion of 0 to 30 parts by weight can be mentioned.

Further, in the present invention, a mixture of the above gelled hydrocarbon and petrolatum can be used as the base material.

Here, as the petrolatum, any petrolatum which is usually used as a base for external use can be used, and examples thereof include yellow petrolatum, white petrolatum and mixtures thereof. It is also possible to use a hydrophilic petrolatum which has been exposed to white petrolatum, stearyl alcohol and cholesterol. The proportion of petrolatum is 10 to 50 parts by weight, preferably 10 to 40 parts by weight, and more preferably 10 to 30 parts by weight, based on 100 parts by weight of the gelled hydrocarbon contained in the denture stabilizer. be able to.

Further, the denture stabilizer of the present invention may contain, in addition to the above components, at least one selected from the group consisting of cellulose derivatives and salts thereof.

The cellulose derivative can be uniformly dispersed in the gelled hydrocarbon, and as a result, a long-term storable denture stabilizer having excellent stability over time can be prepared. Further, the denture stabilizer can absorb water in the oral cavity and exhibit an appropriate adhesive force by containing a cellulose derivative or the like, and can contribute to stabilization and fixation of the denture in the oral cavity.

From the viewpoint of safety, the cellulose derivative is not particularly limited as long as it can be used as a component of a denture stabilizer, and examples thereof include carboxymethyl cellulose, carboxymethyl ethyl cellulose, hydroxypropyl cellulose, croscarmellose, and Examples thereof include crosslinked polymers. Preferred are carboxymethyl cellulose and its crosslinked polymers.
The salts of cellulose derivatives preferably include alkali metal salts such as sodium salts and potassium salts and alkaline earth metal salts such as calcium salts and magnesium salts. The viscosity of the cellulose derivative and salts thereof is not particularly limited, but is usually room temperature (15 to
At 25 ° C., it is 7-16,000 cps, preferably 1,000-16,000 cps.

The blending ratio of these cellulose derivatives is
Although it cannot be uniformly defined depending on the type of cellulose derivative to be blended, for example, when carboxymethyl cellulose is blended, it is usually 5 to 40 parts by weight, preferably 10 to 30 parts by weight, more preferably 100 parts by weight of the denture stabilizer. Can be added in an amount of 15 to 25 parts by weight, and other cellulose derivatives can be added in accordance with this.

Furthermore, the denture stabilizer of the present invention may contain a lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof.

The lower alkyl vinyl ether / maleic anhydride copolymer has a lower alkyl group having 1 carbon atom.
8 to 8, especially 1 to 6 are used, and specifically, methoxyethylene maleic anhydride copolymer, ethyl vinyl ether maleic anhydride copolymer, propyl vinyl ether maleic anhydride copolymer, isobutyl vinyl ether maleic anhydride. An acid copolymer or the like, or a calcium salt, sodium salt, zinc salt, strontium salt, magnesium salt or the like thereof can be used. Further, as the derivative thereof, an ester with an alcohol having 1 to 8 carbon atoms can be used, and specifically, a half ester of maleic anhydride or the like can be used. These lower alkyl vinyl ether / maleic anhydride copolymers or derivatives thereof may be used alone or in combination of two or more.

By blending a lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof with a denture stabilizer, the fixing force of the denture and its durability are improved.
For this purpose, a lower alkyl vinyl ether / maleic anhydride copolymer or its derivative is 200,000-24.
Those having a weight average molecular weight of 0,000 are preferable. More preferably, it has a weight average molecular weight of 1 to 2,000,000.

The amount of the lower alkyl vinyl ether / maleic anhydride copolymer or its derivative to be added per 100 parts by weight of the denture stabilizer of the present invention is usually 10 to 6.
The proportion may be 0 parts by weight, preferably 20 to 50 parts by weight, more preferably 30 to 40 parts by weight.

In the denture stabilizer of the present invention, other water-soluble polymers can be blended in addition to the above-mentioned components. As such a water-soluble polymer, for example, alginic acid,
Natural polymers such as sodium alginate, gum arabic, tragacanth, locust bean gum, xanthan gum, guar gum, agar, karaya gum, carrageenan;
Examples thereof include polyvinylpyrrolidone, polyvinyl alcohol, methyl vinyl ether, copolymers of methyl vinyl ether and maleic anhydride, copolymers of acrylamide and acrylic acid, sodium polyacrylate, and synthetic polymers such as polyethylene oxide. ..

Further, the denture stabilizer of the present invention contains, as far as the effects of the present invention are not impaired, dispersion stabilizers such as fatty acid dextrin and polyethylene homopolymer, preservatives such as methylparaben, ethylparaben and propylparaben, and the like. A pH adjusting agent, a surfactant, a pigment, a fragrance, a dye, an antiseptic, a disinfectant, a bactericide, an anti-flame agent and the like can also be added.

The denture stabilizer of the present invention can be produced by mixing and dispersing desired components in the same manner as the conventional non-aqueous denture stabilizer, and can be used in the same manner as the conventional non-aqueous denture stabilizer.

[0028]

EXAMPLES The present invention will be described in more detail below with reference to experimental examples and examples. However, the present invention is not limited to such experimental examples. Unless otherwise specified,% shown below means% by weight.

Example 1, Comparative Example 1 According to the formulation shown in Table 1, a denture stabilizing composition was prepared.

[0030]

[Table 1]

Specifically, an oily component (gelled hydrocarbon,
It was prepared by heating and mixing white petrolatum and light liquid paraffin, and then adding a water-soluble polymer and uniformly mixing.

Experimental Example 1 Stability over Time The denture stabilizing compositions prepared in Example 1 and Comparative Example 1 above were measured for storage stability and compared. Specifically, put these compositions in a closed glass container,
Store at 40 ℃ for 1 month, 3 months and 6 months,
The separation rate of the oil component generated in the composition was measured. The oil separation rate (%) was calculated as the ratio of the volume occupied by the separated oil content after storage to 100% of the total volume of the sample composition. The results are shown in Table 2.

[0033]

[Table 2]

From these results, it was found that the oil of Example 1 can be suppressed more effectively than the oil of Comparative Example 1.

Experimental Example 2 Adhesion Test In order to evaluate the adhesive force of the denture stabilizer prepared in Example 1 and Comparative Example 1 above, an experiment described below was carried out using a rheometer CR200D (manufactured by Sun Kagaku Co.). I went.

An acrylic resin plate in which a hole having a diameter of 22 mm ² and a depth of 0.5 mm was processed was used as a sample holder, the sample was filled in the hole of the sample holder, and the surface was flattened. It was immersed in a constant temperature water bath for 1 minute. After that, the sample holder was taken out, the water was wiped off lightly, and the sample was fixed on the sample stand of the rheometer CR200D. Next, the adapter was crimped to the sample at a crimping speed of 5 mm / min and a crimping load of 500 g (4.9 N), held for 30 seconds, and then pulled in the opposite direction at 5 mm / min to give the maximum force D (g ) Was measured. The adhesive force (Pa) was calculated from the measured maximum force D based on the following equation.

[0037]

[Formula 1]

The results obtained are shown in Table 3. As a result, it was confirmed that Example 1 had an excellent adhesive force as compared with Comparative Example 1.

[0039]

[Table 3]

Experimental Example 3 Adhesion Persistence Test The denture stabilizers prepared in Example 1 and Comparative Example 1 above were evaluated for adhesion persistence. Specifically, Rheometer CR
200D (manufactured by Sun Kagaku Co.) was used to dip the denture stabilizer-filled sample holder in a constant temperature water bath for 1, 60, 18
The test was performed in the same manner as in Test Example 2 except that the sample was treated for 0 and 360 minutes.

The obtained results are shown in FIG. FIG. 1 shows the adhesive force held by the denture stabilizer during the immersion time of each sample holder. As a result, it was confirmed that in Example 1 using gelled hydrocarbon, the adhesive strength as high as in Comparative Example 1 was retained, and the denture stabilizer of Example 1 was excellent in adhesiveness persistence. I found out.

[0042]

The denture stabilizer of the present invention is characterized by using a gel-like material formed from a specific amount of liquid paraffin and polyethylene as a base material. It is possible to significantly improve problems such as separation of the content components of the denture stabilizer, syneresis and oil floating due to the influence of heat during storage, especially during storage. That is, according to the present invention, a denture stabilizer having excellent storage stability can be provided. Furthermore, the denture stabilizer of the present invention, while maintaining such stability as it is, the consistency, hardness or viscosity can be appropriately adjusted by blending carboxymethyl cellulose and other water-soluble polymers, and the like. A denture stabilizer having excellent adhesion stability can be provided. Further, by using ME maleic anhydride copolymer or a salt thereof in combination with carboxymethyl cellulose, the tackiness in the oral cavity can be significantly prolonged. That is, according to the present invention, it is possible to provide a denture stabilizer which can be used in a stable state in the oral cavity for a long period of time and which has an improved feeling of use and improved use condition.

[Brief description of drawings]

FIG. 1 shows the adhesive force retained by a denture stabilizer during immersion time of each sample holder.

Claims (4)

[Claims] 1. A denture stabilizer containing gelled hydrocarbon or a mixture of gelled hydrocarbon and petrolatum as a base material. 2. The denture stabilizer according to claim 1, which further contains at least one selected from the group consisting of cellulose derivatives and salts thereof. 3. The denture stabilizer according to claim 2, wherein the cellulose derivative is carboxymethyl cellulose. 4. The denture stabilizer according to claim 1, further comprising a lower alkyl vinyl ether / maleic anhydride copolymer and a derivative thereof.