JP2003052806A - Blood bag - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a blood bag capable of reducing the rate of breakage in handling for low-temperature storage. SOLUTION: This blood bag is manufactured from a sheet formed by adding 70 wt parts plasticizer 30 and 40 wt parts chlorinated polyethylene 5 to 100 pts.wt. vinyl chloride resin. The chlorinated polyethylene is amorphous chlorinated polyethylene.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a blood bag suitable for storing and preserving blood components, especially a liquid containing red blood cells, and capable of reducing damage at low temperatures.

[0002]

2. Description of the Related Art Properties required for a blood bag include flexibility for facilitating operations such as blood collection, blood transfusion, and blood component separation, strength capable of withstanding these operations, and hygiene. Safety etc. are mentioned. Since soft polyvinyl chloride containing a plasticizer (hereinafter also referred to as soft PVC) substantially satisfies the above-mentioned required performance, it is currently the mainstream material for blood bags.

However, in flexible PVC, at low temperatures (from 5 ° C-
Since the durability at 40 ° C) is low and the damage during use is not small, there is a great need for a blood bag having high strength at low temperature. Therefore, in view of the above situation, the present invention has been made to provide a blood bag having excellent durability and strength at low temperatures.

[0004]

Means for Solving the Problems As a result of intensive studies to solve the above-mentioned problems, the present inventors first found that soft PV was used.
Inspired by adding other polymers to C, chlorinated polyethylene (hereinafter C-PE) is the most suitable polymer.
(Also referred to as ()) was made into a sheet by adding a soft PVC to a blood bag, and a blood bag excellent in durability and strength at low temperature was invented.

[1] The present invention provides a blood bag made from a sheet formed by adding 30 to 70 parts by weight of a plasticizer and 5 to 40 parts by weight of chlorinated polyethylene to 100 parts by weight of vinyl chloride resin. provide. [2] The present invention provides the blood bag according to [1], wherein the chlorinated polyethylene is amorphous chlorinated polyethylene. [3] In the present invention, the polyvinyl chloride resin has a degree of polymerization of 1
000 to 2500, the chlorinated polyethylene has a chlorine content of 25 to 40% by mass, [1] to [2]
The blood bag described in 1. is provided. [4] The plasticizer is a phthalic acid ester, a phosphoric acid ester, a citric acid ester, or an epoxy-based plasticizer,
A blood bag according to any one of [1] to [3] is provided.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, although not limited to any theory, a moderate affinity between polyvinyl chloride and chlorinated polyethylene, preferably amorphous chlorinated polyethylene, is durability at low temperature. I think that it controls. This is because polyvinyl chloride is not crystalline and has high compatibility with amorphous chlorinated polyethylene.

The polyvinyl chloride of the present invention has a degree of polymerization of 1
000 to 2500 are used. Degree of polymerization is 10
When it is less than 00, the impact strength is low, and when the degree of polymerization exceeds 2500, the moldability is poor, which is not preferable. The chlorinated polyethylene of the present invention (preferably chlorinated polyethylene),
It is obtained by chlorinating a thermoplastic polyethylene by a generally known method. A chlorine content of 25 to 40% by mass is used. If the chlorine content is less than 25% by mass, the affinity with the polyvinyl chloride resin is low, and if it exceeds 40% by mass, the cold resistance is deteriorated, which is not preferable.

The amount of chlorinated polyethylene added to polyvinyl chloride is 5 to 40 parts by weight, preferably 8 to 25 parts by weight, based on 100 parts by weight of PVC resin. If it is less than 5 parts by weight, the expected damage resistance at 4 ° C. to −40 ° C. in handling deteriorates, which is not preferable. On the other hand, if it exceeds 40 parts by weight, the compatibility between polyvinyl chloride and chlorinated polyethylene decreases, and transparency and impact resistance as a blood bag sheet cannot be sufficiently obtained.

As the plasticizer added to the PVC resin, an inexpensive non-cold-resistant plasticizer such as phthalic acid ester, phosphoric acid ester, citric acid ester, and epoxy resin is used. In particular, it is not the expensive cold-resistant plasticizers such as dioctyl sebacate and diazetyl azelate, but the inexpensive non-cold-resistant 2-ethylhexyl phthalate (hereinafter also referred to as DOP), etc., added to the cold-resistant blood of the present invention. It is effective in bag manufacturing cost. Plasticizer is PVC resin: 100
It is advisable to add 30 to 70 parts by weight, preferably 35 to 60 parts by weight, relative to parts by weight. If the amount is less than 30 parts by weight, the flexibility of the blood bag sheet is insufficient, which is not preferable. On the other hand, if it exceeds 70 parts by weight, the strength required for the blood bag cannot be obtained, and the blood bag sheet becomes impractical. As other additives, stabilizers such as epoxidized soybean oil (hereinafter also referred to as ESBO), calcium stearate and zinc stearate are used.

The above-mentioned polyvinyl chloride resin, plasticizer, chlorinated polyethylene and the like are mixed at a predetermined ratio to form a single layer sheet, and two sheets of these sheets are laminated to form a blood bag. The thickness of the sheet is 0.
The thickness is 25 mm to 0.5 mm, preferably 0.35 mm to 0.45 mm. If it is less than 0.25 mm, it tends to be broken, and if it exceeds 0.5 mm, it is not preferable because it is poor in bag-making property and is not practical.

[0011]

EXAMPLES The present invention will be specifically described below based on examples. In Examples 1 to 3 and Comparative Example 1, S-1003 (average degree of polymerization 1300) manufactured by Kanega Fuchi Chemical Co., Ltd. as a vinyl chloride resin, 302NA manufactured by Showa Denko KK as a chlorinated polyethylene (chlorine content 30% by mass) ), And 2-ethylhexyl phthalate (DOP) was used as a plasticizer. (Preparation of blood bag) Table 1 in Examples 1 to 3
As described in the above, with respect to 100 parts by weight of vinyl chloride resin, 9 to 21 parts by weight of chlorinated polyethylene and 35 to 4 parts of plasticizer are used.
5 parts by weight, a stabilizer and the like are mixed at a predetermined ratio to give a thickness of 0.4.
A 0 mm sheet was formed, and two sheets were superposed to form a bag, to prepare a blood bag. Further, in Comparative Example 1, as shown in Table 1, chlorinated polyethylene was not added, but a plasticizer was added in a larger amount than in Examples 1 to 3 (50 parts by weight), and blood was added in the same manner as in Examples 1 to 3. A bag was made. (Damage Test of Frozen Blood Bag) Each blood bag (300 ml capacity) produced as described above was sterilized by high pressure steam and then filled with 160 ml of water, and the bag was kept at -30 ° C. for 24 hours.
After storage for a period of time, the bag was dropped from a height of 1 m onto flat concrete from the abdomen of the bag, and damage to the container was examined. (Results) From the results shown in Table 1, the breakage rate of Examples 1 to 3 of the present invention was 15 to 35%, which was significantly lower than that of Comparative Example 1 (75%).

[0012]

[Table 1]

[0013]

By adding chlorinated polyethylene to polyvinyl chloride, it is possible to greatly reduce the damage rate during handling when the blood bag is stored at a low temperature. Since the above effects can be obtained by adding an inexpensive non-cold-resistant plasticizer without using an expensive cold-resistant plasticizer, it is possible to obtain a low-temperature resistant blood bag at low cost.

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Claims (4)

[Claims] 1. A plasticizer 30 to 70 parts by weight and a chlorinated polyethylene 5 to 4 per 100 parts by weight of vinyl chloride resin.
A blood bag characterized by being made into a bag from a sheet formed by adding 0 part by weight. 2. The blood bag according to claim 1, wherein the chlorinated polyethylene is amorphous chlorinated polyethylene. 3. The polyvinyl chloride resin has a degree of polymerization of 100.
The blood bag according to claim 1 or 2, wherein the chlorine content of the chlorinated polyethylene is 0 to 2500, and the chlorine content is 25 to 40% by mass. 4. The blood bag according to claim 1, wherein the plasticizer is a phthalate ester, a phosphate ester, a citrate ester, or an epoxy plasticizer.