JP2003038175A - 新規ポリケチドの組換え産生 - Google Patents

新規ポリケチドの組換え産生

Info

Publication number
JP2003038175A
JP2003038175A JP2002200189A JP2002200189A JP2003038175A JP 2003038175 A JP2003038175 A JP 2003038175A JP 2002200189 A JP2002200189 A JP 2002200189A JP 2002200189 A JP2002200189 A JP 2002200189A JP 2003038175 A JP2003038175 A JP 2003038175A
Authority
JP
Japan
Prior art keywords
pks
gene
polyketide
promoter
gene cluster
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2002200189A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003038175A6 (ja
Inventor
Chaitan Khosla
コスラ チェイタン
David A Hopwood
エイ． ホップウッド ディビッド
Susanne Ebert-Khosla
エバート−コスラ スザーン
Robert Mcdaniel
マックダニエル ロバート
Hong Fu
フ ホン
Camilla Kao
カオ キャミーラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JOHN INNES CENTRE
Innes John Institute
Leland Stanford Junior University
Original Assignee
JOHN INNES CENTRE
Innes John Institute
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JOHN INNES CENTRE, Innes John Institute, Leland Stanford Junior University filed Critical JOHN INNES CENTRE
Publication of JP2003038175A publication Critical patent/JP2003038175A/ja
Publication of JP2003038175A6 publication Critical patent/JP2003038175A6/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2002200189A 1993-09-20 2002-07-09 新規ポリケチドの組換え産生 Withdrawn JP2003038175A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12373293A 1993-09-20 1993-09-20
US08/123,732 1993-09-20
US08/164,301 1993-12-08
US08/238,811 1994-05-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP7509422A Division JPH09505983A (ja) 1993-09-20 1994-09-20 新規ポリケチドの組換え産生

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2003161286A Division JP3994070B2 (ja) 1993-09-20 2003-06-05 新規ポリケチドの組換え産生
JP2003336370A Division JP2004083592A (ja) 1993-09-20 2003-09-26 新規ポリケチドの組換え産生

Publications (2)

Publication Number Publication Date
JP2003038175A true JP2003038175A (ja) 2003-02-12
JP2003038175A6 JP2003038175A6 (ja) 2005-02-03

Family

ID=22410531

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2002200189A Withdrawn JP2003038175A (ja) 1993-09-20 2002-07-09 新規ポリケチドの組換え産生
JP2002373049A Withdrawn JP2003204784A (ja) 1993-09-20 2002-12-24 新規ポリケチドの組換え産生
JP2003161286A Expired - Lifetime JP3994070B2 (ja) 1993-09-20 2003-06-05 新規ポリケチドの組換え産生
JP2003336370A Withdrawn JP2004083592A (ja) 1993-09-20 2003-09-26 新規ポリケチドの組換え産生
JP2004206501A Withdrawn JP2004344173A (ja) 1993-09-20 2004-07-13 新規ポリケチドの組換え産生

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2002373049A Withdrawn JP2003204784A (ja) 1993-09-20 2002-12-24 新規ポリケチドの組換え産生
JP2003161286A Expired - Lifetime JP3994070B2 (ja) 1993-09-20 2003-06-05 新規ポリケチドの組換え産生
JP2003336370A Withdrawn JP2004083592A (ja) 1993-09-20 2003-09-26 新規ポリケチドの組換え産生
JP2004206501A Withdrawn JP2004344173A (ja) 1993-09-20 2004-07-13 新規ポリケチドの組換え産生

Country Status (1)

Country Link
JP (5) JP2003038175A (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100920782B1 (ko) * 2008-10-13 2009-10-08 한국과학기술원 미생물 유전체 분석 기반 타입-2 폴리케타이드 합성 효소 및 폴리케타이드 예측 시스템 및 방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100920782B1 (ko) * 2008-10-13 2009-10-08 한국과학기술원 미생물 유전체 분석 기반 타입-2 폴리케타이드 합성 효소 및 폴리케타이드 예측 시스템 및 방법

Also Published As

Publication number Publication date
JP2003325178A (ja) 2003-11-18
JP2004083592A (ja) 2004-03-18
JP2003204784A (ja) 2003-07-22
JP3994070B2 (ja) 2007-10-17
JP2004344173A (ja) 2004-12-09

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