JP2002535966A5 - - Google Patents
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- JP2002535966A5 JP2002535966A5 JP2000591070A JP2000591070A JP2002535966A5 JP 2002535966 A5 JP2002535966 A5 JP 2002535966A5 JP 2000591070 A JP2000591070 A JP 2000591070A JP 2000591070 A JP2000591070 A JP 2000591070A JP 2002535966 A5 JP2002535966 A5 JP 2002535966A5
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- JP
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- Prior art keywords
- smez
- rspe
- changed
- positions
- smez2
- Prior art date
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- 108010016626 Dipeptides Proteins 0.000 description 2
- 231100000765 Toxin Toxicity 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 108020003112 toxins Proteins 0.000 description 2
- 230000001809 detectable Effects 0.000 description 1
- 230000002297 mitogenic Effects 0.000 description 1
- 230000003389 potentiating Effects 0.000 description 1
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Description
ＳＭＥＺとＳＭＥＺ−２の間の最も有意な差異は、位置９６〜１００の交換されたペンタペプチド配列であって、そこではＳＭＥＺのＥＥＰＭＳ配列がＳＭＥＺ−２ではＫＴＳＩＰに変えられている（図１）。第２の差異は位置１１１〜１１２であり、そこではＲＲジペプチドがＳＭＥＺではＧＫに変えられている。残りの１０個の異なる残基は、ほぼ一次配列全体に広がっている。
ＳＭＥＺとＳＭＥＺ−２の間の最も有意な差異は、位置９６〜１００のペンタペプチド配列の交換であって、そこではＳＭＥＺのＥＥＰＭＳ配列がＳＭＥＺ２ではＫＴＳＩＰに変えられている（図１）。第２のクラスターは位置１１１〜１１２であり、ＲＰジペプチドがＳＭＥＺ−２ではＧＫに変えられている。残りの１０の異なる残基は一次配列のほぼ全体に広がっている。
rＳＰＥ−ＧおよびrＳＰＥ−Ｈについての１／２最大反応は、それぞれ２ｐｇ／ｍｌおよび５０ｐｇ／ｍｌであった。各々０.０２ｐｇ／ｍｌおよび０.１ｐｇ／ｍｌ未満では活性は検出されなかった。したがって双方の毒素は、rＳＰＥ−Ｃよりも効力が低かった。組換えＳＭＥＺはrＳＰＥ−Ｃと効力において同様であり、Ｐ５０％値は０.０８ｐｇ／ｍｌで、０.５ｆｇ／ｍｌ未満では検出可能な増殖はなかった。組換えＳＭＥＺ−２は、測定されたすべての、あるいは他に述べられた測定可能な限りの毒素よりも強い分裂促進能を示した。 Ｐ５０％値は０.０２ｐｇ／ｍｌと測定され、ｒＳＭＥＺ−２は少なくとも０.１ｆｇ／ｍｌ未満においてもまだ活性があった。すべてのＰ５０％値は表１にまとめられている。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ33358998 | 1998-12-24 | ||
| NZ333589 | 1998-12-24 | ||
| PCT/NZ1999/000228 WO2000039159A1 (en) | 1998-12-24 | 1999-12-24 | Superantigens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002535966A JP2002535966A (ja) | 2002-10-29 |
| JP2002535966A5 true JP2002535966A5 (ja) | 2006-10-19 |
Family
ID=19927091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000591070A Pending JP2002535966A (ja) | 1998-12-24 | 1999-12-24 | 超抗原 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1141000A4 (ja) |
| JP (1) | JP2002535966A (ja) |
| AU (1) | AU764650B2 (ja) |
| CA (1) | CA2356755A1 (ja) |
| WO (1) | WO2000039159A1 (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ519371A (en) * | 2002-06-04 | 2004-11-26 | Auckland Uniservices Ltd | Immunomodulatory constructs and their uses |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE325617T1 (de) * | 1997-12-02 | 2006-06-15 | Idaho Res Found | Nicht-toxische immun-stimulierende enterotoxin- zusammensetzungen |
-
1999
- 1999-12-24 CA CA002356755A patent/CA2356755A1/en not_active Abandoned
- 1999-12-24 EP EP99962603A patent/EP1141000A4/en not_active Withdrawn
- 1999-12-24 AU AU19010/00A patent/AU764650B2/en not_active Ceased
- 1999-12-24 WO PCT/NZ1999/000228 patent/WO2000039159A1/en active IP Right Grant
- 1999-12-24 JP JP2000591070A patent/JP2002535966A/ja active Pending
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