JP2002532845A - 衝突誘導解離を使用する分子構造分析用のインライン反射飛翔時間型質量分析計 - Google Patents
衝突誘導解離を使用する分子構造分析用のインライン反射飛翔時間型質量分析計Info
- Publication number
- JP2002532845A JP2002532845A JP2000588791A JP2000588791A JP2002532845A JP 2002532845 A JP2002532845 A JP 2002532845A JP 2000588791 A JP2000588791 A JP 2000588791A JP 2000588791 A JP2000588791 A JP 2000588791A JP 2002532845 A JP2002532845 A JP 2002532845A
- Authority
- JP
- Japan
- Prior art keywords
- ions
- ion
- precursor
- mass
- reflectron
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000001360 collision-induced dissociation Methods 0.000 title claims description 16
- 238000004458 analytical method Methods 0.000 title description 2
- 150000002500 ions Chemical class 0.000 claims description 195
- 239000002243 precursor Substances 0.000 claims description 57
- 238000000034 method Methods 0.000 claims description 14
- 239000006185 dispersion Substances 0.000 claims description 10
- 238000004885 tandem mass spectrometry Methods 0.000 claims description 8
- 239000012491 analyte Substances 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 239000012634 fragment Substances 0.000 description 9
- 238000010884 ion-beam technique Methods 0.000 description 8
- 230000005684 electric field Effects 0.000 description 7
- 238000004949 mass spectrometry Methods 0.000 description 7
- 238000001228 spectrum Methods 0.000 description 7
- 238000010494 dissociation reaction Methods 0.000 description 6
- 230000005593 dissociations Effects 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 238000013461 design Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 238000000132 electrospray ionisation Methods 0.000 description 4
- 238000010265 fast atom bombardment Methods 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- 230000002123 temporal effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 2
- 238000013383 initial experiment Methods 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 108010022337 Leucine Enkephalin Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 102100025490 Slit homolog 1 protein Human genes 0.000 description 1
- 101710123186 Slit homolog 1 protein Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000005040 ion trap Methods 0.000 description 1
- 230000005596 ionic collisions Effects 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- URLZCHNOLZSCCA-UHFFFAOYSA-N leu-enkephalin Chemical compound C=1C=C(O)C=CC=1CC(N)C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=CC=C1 URLZCHNOLZSCCA-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000012916 structural analysis Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
- H01J49/405—Time-of-flight spectrometers characterised by the reflectron, e.g. curved field, electrode shapes
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
- H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11261598P | 1998-12-17 | 1998-12-17 | |
| US60/112,615 | 1998-12-17 | ||
| PCT/US1999/030269 WO2000036633A1 (en) | 1998-12-17 | 1999-12-17 | In-line reflecting time-of-flight mass spectrometer for molecular structural analysis using collision induced dissociation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002532845A true JP2002532845A (ja) | 2002-10-02 |
| JP2002532845A5 JP2002532845A5 (enExample) | 2005-11-17 |
Family
ID=22344907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000588791A Pending JP2002532845A (ja) | 1998-12-17 | 1999-12-17 | 衝突誘導解離を使用する分子構造分析用のインライン反射飛翔時間型質量分析計 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1153414A1 (enExample) |
| JP (1) | JP2002532845A (enExample) |
| WO (1) | WO2000036633A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006196216A (ja) * | 2005-01-11 | 2006-07-27 | Jeol Ltd | タンデム飛行時間型質量分析装置 |
| WO2012033094A1 (ja) * | 2010-09-08 | 2012-03-15 | 株式会社島津製作所 | 飛行時間型質量分析装置 |
| CN103841745A (zh) * | 2012-11-20 | 2014-06-04 | 住友重机械工业株式会社 | 回旋加速器 |
| JPWO2019207737A1 (ja) * | 2018-04-26 | 2021-01-07 | 株式会社島津製作所 | 飛行時間型質量分析装置 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0219072D0 (en) * | 2002-08-16 | 2002-09-25 | Scient Analysis Instr Ltd | Charged particle buncher |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4106796A1 (de) * | 1991-03-04 | 1991-11-07 | Wollnik Hermann | Ein flugzeit-massenspektrometer als sekundaerstufe eines ms-ms systems |
| US5689111A (en) * | 1995-08-10 | 1997-11-18 | Analytica Of Branford, Inc. | Ion storage time-of-flight mass spectrometer |
-
1999
- 1999-12-17 JP JP2000588791A patent/JP2002532845A/ja active Pending
- 1999-12-17 WO PCT/US1999/030269 patent/WO2000036633A1/en not_active Ceased
- 1999-12-17 EP EP99966444A patent/EP1153414A1/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006196216A (ja) * | 2005-01-11 | 2006-07-27 | Jeol Ltd | タンデム飛行時間型質量分析装置 |
| WO2012033094A1 (ja) * | 2010-09-08 | 2012-03-15 | 株式会社島津製作所 | 飛行時間型質量分析装置 |
| CN103841745A (zh) * | 2012-11-20 | 2014-06-04 | 住友重机械工业株式会社 | 回旋加速器 |
| JPWO2019207737A1 (ja) * | 2018-04-26 | 2021-01-07 | 株式会社島津製作所 | 飛行時間型質量分析装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1153414A1 (en) | 2001-11-14 |
| WO2000036633A1 (en) | 2000-06-22 |
| WO2000036633A9 (en) | 2001-04-19 |
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