JP2002504397A - Apparatus and method for instructing administration action - Google Patents

Abstract

(57) [Summary] A device for indicating the action of administration is usually provided with an indicator for registering the action of administration of a drug that can be administered regularly. The indicating device (2) includes detection means (7) arranged to detect the mechanical movement of the medication administration unit (1) that occurs in connection with the act of administration. The pointing device (2) includes a registration unit provided to register information on the administration action in the pointing device (2). The indicating device is another unit that can be attached to the drug administration unit (1) or can be located at the drug administration unit, and can be used, for example, to monitor the administration of insulin in the treatment of diabetes.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001] The present invention relates to a device for indicating an administration action, comprising an indicator for registering an administration action of a medicine to be normally administered regularly. The present invention also relates to a method for instructing the administration as described above.

[0002] It has a timer-based alarm system for doses taken at regular intervals, in the form of pills or tablets or corresponding doses taken orally, usually taken at regular intervals It is well known to use various pharmaceutical containers. For example, British Patent Publication No. 2,179,919 discloses a drug container that provides an alarm that can be stopped by simply opening the container. Such containers may also hold syringes or ampules. French Patent Publication No. 2,666,225 then discloses an alarm system for a drug container with compartments for pills or tablets or corresponding orally administered doses, each compartment comprising: It has a separate lid and a separate alarm. The alarm is automatically turned off within 15 seconds, so that no information is left in the container as to whether the dose has been taken.

There is a system integrated with a syringe for a dose to be injected by a power injector, which system is used to control the administration of the dose in combination with the electronics belonging to the syringe. Is done. For example, U.S. Pat. No. 4,417,889 discloses a system that prevents excess dose and is integrated with a syringe, a type of time lock, in which a second dose is given a predetermined period after the dose is given. The use of a syringe is prevented. In fact, the syringe is operated by an electric motor based on the detection of the dose and the storage of the data. U.S. Pat. No. 4,950,245 discloses an "injection pen", a syringe intended for use in diabetics, which can be used to administer a predetermined dose of insulin. . The syringe has a system integrated with a sensor that monitors the progress of the pump rod inside the syringe and provides information at the time of injection to an electronic control unit for dispensing accurate doses. In this syringe, the indication that the waiting container is empty is the only alarm.

[0004] To date, there has been no detection device or method for controlling the action of administration applicable to various syringes. For example, diabetics must receive medication at regular intervals. However, it may be uncertain whether or not the administration has really taken place. For example, the most common injection pens are of the type in which a push button is set backwards and a dose is administered by pressing the push button during an injection, wherein the push button is a piston in a medicament container. Is moved forward by the set distance. Different types of doses in the regimen
A similar problem arises, for example, when administered within a day, making it difficult to maintain registration for the administered dose.

It is an object of the present invention to provide a device in which the act of administering a dose can be detected in a reliable manner. To this end, the device according to the invention is characterized in a first aspect by including a detector arranged to detect the mechanical movement of the medication administration unit associated with the act of administration. This movement may be movement of a piston in the dosing unit, or a part dynamically connected to the piston, or
It may be to remove the dosing unit from the support provided for the dosing unit.

It is also an object of the present invention to provide a method for detecting the act of administration. To this end, the method comprises that the dosing unit is provided with a separate detachable indicating device, and when dispensing the substance, a specific detecting means belonging to the indicating device detects the mechanical movement. It is used for detecting, and the first characteristic is that the action is automatically registered in the memory from the detecting means.

According to the present invention, a device that is not known and can be easily implemented by an available device,
For example, it is possible to create entirely new regimens for the treatment of diabetes. Therefore, the injection pen itself does not need to be changed in structure, and it is possible to use a commercially available general injection pen, but the injection pen does not have the memory function in question. In addition, the present invention relates to U.S. Pat.
As shown in US Pat. No. 89 and US Pat. No. 4,950,246, a pure mechanical injection pen does not require the use of an electrically operated injection pen but achieves dosing by manual movement. Can be used.

In the following, the present invention will be described in more detail with reference to the accompanying drawings.

FIG. 1 shows a conventional injection pen 1 and a pointing device 2 which is arranged as a separate member around its outside. The indicating device can have, for example, a sleeve-like or corresponding structure, and thus can be fixed to a conventional injection pen without changing the structure of the injection pen. For example, the pointing device can be pushed axially at the rear end of the injection pen to surround the injection pen (arrow). Similarly, the injection pen has another push button piece 3
The push button piece can surround the normal push button and be firmly fixed at the rear end of the injection pen.

FIGS. 2 to 4 show the assembly of the pointing device 2 and the injection pen in an assembled state. The pointing device 2 surrounds the upper end of the injection pen with the press 3 positioned at the bottom. The pointing device 2 includes a battery 4 and a set of indicators 5a, 5
b. The first indicator 5a is provided to indicate the time at which the dose should be administered. The device may also provide movement related to the administration of the dose, in this case movement of a moving part with respect to the body of the injection pen, by means of a push button, a piston, other injection means and / or dynamically It has means 7 for detecting the movement of the connected component. In the embodiment of FIGS. 1 and 2, the movement is retracted to the rearwardly set push button 3, which pushes the piston forward by means of the piston rod, with the set movement, so that the movement is detected during the pushing movement. This is achieved by attaching a part 6 which presses a microswitch on the pointing device 2, which acts as a means. The portion 6 that moves with the movement of the piston may be, for example, a tubular piece received in a space provided in the main body of the pointing device 2 or may be made of a light-transmitting material. In general, it is possible to use movement of any part of the injection pen to signal or to signal the administration of a medicament in the body.

When movement of the piston is recognized in the manner described above, the first indicator 5a transitions to a state reporting that the dose has been administered, for example, the alarm stops.
At the same time, information about the administration of the dose is stored in the device 1 and, if somebody tries to set the injection pen again for administration within a predetermined time from the act of this administration, the second of a set of indicators is set. Indicator 5b gives a warning Also, depending on the capacity of the power supply, such as a battery, the second indicator can be turned on for a predetermined time after administration of the dose or until the next alarm is given. It is. Thus, there is always information available as to whether a previous dose has been administered.

The set of indicators 5a, 5b may be visual indicators, such as, for example, indicator lights. The indicator light may be implemented using light emitting diodes. The indicator lights are preferably lights of different colors, for example one green and the other red. An audible indicator, such as a suitable buzzer, may be provided to provide an audible signal upon activation of either or both indicators. This audible indicator is indicated schematically by reference numeral 5c.

The indicating device 2 is provided with a setting switch 8, which can be used to select an alarm time corresponding to the administration interval. Similarly, the device is provided with a window 17 through which the dosage scale of the injection pen body can be viewed.

FIGS. 3 and 4 show an electronic component 9 arranged on one side of the device 2, the electronic component 9 being provided with a space for a battery. The electronic component includes a connection with the detecting means 7, a memory function necessary for recording the action, and a circuit necessary for controlling the alarm and the indicator.

FIGS. 5 to 7 and 9 show another pointing device 2 applying the same inventive concept. In this case too, the pointing device 2 is a member separate from the injection pen, in this case forming a stand for two or more injection pens 1. The purpose of this stand is to control and monitor the administration of several doses administered during the day. Each injection pen 1 is allocated in the memory of the device a time to perform an injection in a day. When it is time to administer the dose from the pen, a visual indicator by the pen indicates that the dose should be administered from the pen. An audible alert is also provided. When a dose is dispensed from a pen, the visual indicator for the pen remains for a predetermined period of time, e.g., until the beginning of the same pen's standby time, indicating that the dose has already been dispensed from that pen. . This is preferably indicated by a brightly illuminated color that can be easily detected. The indicator for the pen indicating that the dose should be administered or the indicator indicating that the dose has been administered may be a separate indicator that is "on" and "off". Of course, change the state according to the state of the pen,
For example, it is possible to use the same physical indicator that changes color. The principle of operation is similar to each injection pen 1 to be monitored in the stand. Injection pens work differently and may differ in that each contains a drug to be administered at a given time of day. In the treatment of diabetes, the pen may contain different types of insulin.

The stand shown in FIG. 5 has a recess 10 for placing the injection pen in an upright position on the stand. The main principles of operation are similar to the embodiment of FIGS. 1-3 and are best illustrated in FIG. Each injection pen 1 has a set of indicators 5
a and 5b are allocated. The device is arranged to issue an alarm in a predetermined sequence, wherein the first indicator 5a of each injection pen issues an alarm indicating that it is time to administer the dose from the respective injection pen. The pointing device 2 detects that the injection pen has been removed from the stand by means of an arrangement in which the device comprises means 7 for detecting the movement of the injection pen removed in a suitable manner from the stand. It is also possible in this case to use a suitable microswitch that operates on the principle of contact, for example a switch located at the bottom of each recess 10. When the sensor detects the removal of the injection pen 1, the state of the indicator 5a that issues the first alarm is reset. At the same time, the second indicator 5b shifts to a state indicating that the dose has been administered. For example, a visual indicator such as an indicator light can be used. Simultaneously with the sign of the removal of the injection pen, the light of the first indicator 5a is turned off and the second indicator 5b is turned on. This can be realized in practice in the same way as the embodiments of FIGS. 1 and 2 by means of light-emitting diodes.

Furthermore, the device 2 has, for example, beside the recess 10 for receiving an injection pen, an alarm setting switch 8 similar to the one described above, one for each injection pen 1. These switches may also be used, for example, to set the time at which one of the switches will be alerted during the day, and the next switch to set the interval between doses, ie, the time to the next alert. Can be used to set appropriate time intervals in any way that is available.

The figure shows a stand for five injection pens corresponding to five doses per day. If the number of doses is smaller, the space left at the end of the stand may be left empty.

FIG. 6 shows another indicator panel 12, which is connected to a stand by a connecting cable 11, which has a similar way to a set of indicators in the stand. Indicators 5a,
5b, and also has an additional audible indicator 5c, such as a buzzer, common to all indicators. In addition, the device includes a mains transformer 13, a "power on" indicator 14 on the indicator panel, and a main switch 15, which is on the stand but may be on the indicator panel 12.

FIG. 7 shows how to use the apparatus of FIGS. 4 and 5. The injection pens 1 can be on a stand at a temperature appropriate for them, for example in a refrigerator 16. An indicator panel is provided with connecting cables outside the refrigerator or the corresponding space, the indicator panel continuously reporting status. In this way, the dosing status is continuously monitored and the dose is kept at a suitably low temperature. Refrigerators are not required if allowed by room temperature or if the drug to be administered is stable. In this case, no other panel is brought outside the refrigerator, but all functions can be included in a similar device body. On the other hand, another indicator panel provided with connecting cables would be useful in situations where it would be desirable to have the indicator in a visible place, even if the actual stand was not held in a closed place.

The injection pen held on the stand may still have an indicating device 2 according to FIGS. 1 to 4 and registers both removal of the injection pen from the stand and administration of the substance from the injection pen. It is possible to

FIG. 8 shows another pointing device that is also suitable for use with a pen-type injection means. The device can be used to set up to two injection times, providing an alarm as needed. When the switch is pressed at a first time during the time of the day when the first dose has to be administered, the device sounds the buzzer once by the buzzer 5c as a sign that the first alarm time has been set. . When the switch is pressed again at a second time of day, this time is set as a second alarm time;
The device will sound the buzzer twice as this sign. When the switch is pressed thereafter, the device will sound the buzzer three times as a sign that both alarm times have already been set.
If the switch is pressed continuously for a predetermined period of time, for example for at least 3 seconds, both alarm times are reset. This causes the device to sound the buzzer five times and return to its initial state. Thus, the setting switch 8 is the only switch operating on the principle of pressing, and the timer of the device registers the time of day as the alarm time when the switch is pressed.

The detection means 7 is a microswitch that detects the movement of the piston of the injection pen, ie, the injection and administration of the injection solution. The microswitch protrudes from the end of the device 2 and the push button at the pen end may be an extension piece arranged around the push button of a commercially available pen according to FIG. 1 and pushes the switch down to its normal position.
When the pen is set for dosing, the pushbutton moves backward to release the switch, and after setting, when the injection is dispensed, the pushbutton again presses the microswitch.

Each timing has a standby period that starts one hour before the alarm time and ends two hours after the alarm time. When it is time to administer the dose, the device will sound a buzzer 5c.
Sounds the buzzer four times. If the dose is administered within one hour before the selected alarm time, no alarm will be required and will not be given. If the injection pen is injected again during the dose standby (ie at least for the second time), the device will provide three audible signals by the buzzer 5c, thereby alerting that the same injection will be administered twice. . At the same time, a visual indicator, for example indicator light 5
Blinks at the pace of the acoustic signal. Since this warning signal is not given at other times, for example, the insulin container can be replaced at that time without warning.

When the push button is placed rearward and returned forward, ie the microswitch is returned to its initial state, the device registers the administration of the dose. It is sufficient to place the push button backwards while giving a warning for a double infusion.

[0026] It can be noted that if the administration of a dose is not registered within a predetermined time, the same alarm will be administered. This notice can be repeated at predetermined time intervals. The following table summarizes the acoustic signals of the device.

[0027]

[Table 1]

FIG. 9 shows an indicating device 2 intended for some dosing units 1. Pressing a specific setting switch on the dosing unit sets the alarm time, FIG.
It is possible to reset the timing according to a principle similar to that of. When the switch is pressed at a first time (e.g., with a sharp tool such as a pen), the device sounds the buzzer once with the buzzer 5c as a sign that the alarm time has been set. When the switch is pressed again, the device sounds the buzzer four times as a sign that the alarm time has already been set (error signal). By continuously pressing the switch for a predetermined period of time, for example at least 3 seconds, the alarm time is reset. The device has 5 buzzers
The alarm is sounded and the alarm of the injection pen whose setting switch 8 is pressed is turned off.

Each timing has a standby period that starts one hour before the alarm time and ends three hours after the alarm time. During the stand-by period, administration of the injection is monitored. When the set alarm time comes, the device sounds an alarm by an acoustic signal and the green light is turned on with the correct injection pen. If the standby period comes before the actual alarm, the green light may already be on. The detector 7 on the stand of the injection pen
It detects that the injection pen has been lifted from the stand, that is, that the injection solution has been administered. Note that when the pen is lifted at the appropriate time, the green signal light turns off and the red signal light illuminates the corresponding pen to administer the injection. The red signal light is turned off only one hour before the alarm time of the same pen (if it is already allowed to administer a new injection). If the injection pen is lifted one hour before the selected alarm time, no alarm is required and will not be given. If the injection pen is lifted again (ie, at least for the second time) within the standby period, the device will provide eight quick acoustic signals, thereby alerting that the same injection will be administered twice. Since this signal is not provided at other times, for example, the insulin container can be replaced during that period without alarm. There is a short delay (approximately 3-6 seconds) after lifting the pen, for example, if a person notices that the wrong pen has been lifted, the pen will still be down during that period. This delay time is set so that the injection solution cannot be administered during that time. That is, detecting that the pen is replaced within a predetermined maximum time will not register as having administered the dose. It may be noted that if the dose is not registered within a predetermined time, for example within 4 minutes, the device will deliver the dose with a similar alarm. This caution may be repeated at predetermined time intervals. The following table summarizes the acoustic and optical signals of the device.

[0030]

[Table 2]

As an alternative to FIGS. 5 to 7 and 9, a special alarm function may be provided, ie the injection pen is not removed from the stand within a predetermined period, for example during a predetermined standby period And a special alarm different from the alarms of the indicators 5a and 5b. Only after two injection pens intended for continued use have not been removed during each period may such a special alarm be triggered. This alert is provided as a remote alert from outside the user's home via a fixed telephone network or using wireless communication such as GSM technology. Visually, the alarm is indicated to the device as a special signal, for example, both lights are off.

The detection means 7 may be provided to operate according to the contact principle such as a microswitch, but it is also possible to use a non-contact motion sensor such as an optical or magnetic motion sensor, and For the operation of dispensing the dose by means of a corresponding element such as a Hall element or an infrared transceiver, it may be necessary to provide a moving part in relation to the other parts.

The embodiments of FIGS. 5-7 and 9 may be used to monitor the administration of a type of dosage other than the dosage injected from a syringe. For example, the stand can be adapted for other types of medical dosages, for example dosage units containing ampoules.

FIGS. 10 and 11 show a further embodiment. In FIG. 10, the injection pen is provided with a pointing device having a lid that rotates away from the top of the push button. The rotational movement of the lid is detected by the detection means and registered as the administration of the dose. FIG. 11 shows one housing for one injection pen into which the injection pen could be inserted and withdrawn to administer the dose. This housing can be operated in a corresponding way as a stand intended for several pens and has the only difference that it is used to monitor only one dosing unit, Is integrated into the housing.

Furthermore, with all devices, it is possible to use the locking function after the administration of the dose has been registered. Thus, the device is provided with a latch, such as a switch or latch on the stand or housing, that prevents the preparatory procedure for administration, preventing rotation of the lid or removal of the injection pen from the stand or housing as shown in FIG. This locking can be on for a predetermined alert period, which can start from registration of the act of administration or end at a predetermined moment, e.g. This is a long period or a short period, such as the start of a predetermined standby period. In the following, these possibilities will be described with reference to FIG. In the stand 2 the injection pen is intended for the end with a pocket clip at the tip to be located in the compartment 10, which compartment has a wide section with a recess for this on the side And so on. Associated with each space is a latch that protrudes the pocket clip upward in the locked position to prevent withdrawal of the injection pen. When the pen is inserted in the back and the administration of the administration is registered, the latch 18 is operated. The alert period can be set up according to any of the principles described above. The latch is arranged so that when the standby period of the injection pen begins, ie when the dose is allowed to be dispensed from the pen, the latch is finally opened. The latch preferably operates such that energy must be provided to hold it in the locked position and open in the absence of energy,
For example, a magnetic latch that is pulled back to the open position by the effect of a spring when the current is turned off is preferred. Thus, by turning off the current, the pen can be removed from the stand, and the settings are stored in memory if necessary.

The indicating device, especially the one attached to the injection pen, need not have alarm and caution functions, but is administered, for example, in connection with eating, and has a definite time of day. For non-administered doses, it may only be intended to register the dose. On the other hand, in connection with such potent insulins, it is particularly important to prevent double administration.

The device can be implemented with conventional electronics such as various sensors, acousto-optic indicators, microprocessors, timers and memories. Preferably, the memory is a memory that retains the information even when no current is supplied. These means are operatively connected to each other to perform the functions of the device. The electronics technology of the device
In the simplest form, provision is made for registering the dose to be administered, this registration being such that in the simplest form information on the act of dosing is left on the device 2 without data on the quantity of the dose. You may. Also, the device associated with the injection pen can be provided with a function for indicating the amount of the dose, and the detecting means needs to be able to measure the advance amount of the piston.

The pointing device 2 to be fixed to the injection pen may be attached to the pen in several ways. If the injection pen is intended for permanent use, the device may be provided with fixing screws engraved on the surface of the pen, i.e. the device 2 may be mounted from its side, The device has a rotatable or releasable fixing plate that is firmly fixed to the device, between which the pen is firmly clamped. In addition, the device 2
It is pressed around the pen in the longitudinal direction of the pen and is fastened to the device 2 by means of a quick coupling, for example a rotatable quick coupling which is activated by the pressing principle and which is arranged at the end near the tip of the injection pen. This is especially suitable for disposable pens where the insulin container is discarded when empty and the device 2 is easily attachable. The device to which the injection pen is to be fixed may be provided with a rechargeable battery instead of a disposable battery. This battery may be placed with the injection pen on a charging stand. Also, the battery may be connected to a special portable power supply using a cable, or may be connected to the acoustic signal device having a good output capacity via the same cable. The cable may be connected to the device 2 with a plug. The battery of the device 2 thus functions as a backup, generating the current required by the device if another battery is not connected.

The design of the pointing device 2 intended for several dosing units 1 may differ from the device shown above. Although the dosing unit 1 has been shown above as being arranged in an upright position, it may be in a tilted or horizontal position. In addition to the optical and acoustic signals, the device may be provided with additional displays, such as a numerical display proximate to each dosing unit 1 and indicating the quantity of the dose and / or indicating the time of administration. Good. Additional display readings
Of course, it may be changeable.

[Brief description of the drawings]

FIG. 1 is a schematic view showing the principle of the first embodiment relating to the injection pen of the present invention.

FIG. 2 is a side view of the first embodiment associated with the injection pen of the present invention when combined.

FIG. 3 shows the embodiment of FIG. 2 viewed from a direction perpendicular to the direction of FIG. 2;

FIG. 4 is an end view of the first embodiment as viewed from the direction of arrow IV.

FIG. 5 is a side view of a second embodiment of the present invention including several dosing units.

FIG. 6 shows the embodiment of FIG. 5 viewed from above.

FIG. 7 illustrates the use of the embodiments of FIGS. 5 and 6;

FIG. 8 shows another embodiment of the embodiment of FIGS.

FIG. 9 shows another embodiment of the embodiment of FIGS. 5 and 6;

FIG. 10 illustrates a further embodiment of the present invention.

FIG. 11 illustrates a further embodiment of the present invention.

[Procedure amendment]

[Submission date] October 6, 2000 (2000.10.6)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0003

[Correction method] Change

[Correction contents]

There is a system integrated with a syringe for a dose to be injected by a power injector, which system is used to control the administration of the dose in combination with the electronics belonging to the syringe. Is done. For example, U.S. Pat. No. 4,417,889 discloses a system that prevents excess dose and is integrated with a syringe, a type of time lock, in which a second dose is given a predetermined period after the dose is given. The use of a syringe is prevented. In fact, the syringe is operated by an electric motor based on the detection of the dose and the storage of the data. U.S. Pat. No. 4,950,246 discloses an "injection pen", a syringe intended for use in diabetics, which can be used to administer a predetermined dose of insulin. . The syringe has a system integrated with a sensor that monitors the progress of the pump rod inside the syringe and provides information at the time of injection to an electronic control unit for dispensing accurate doses. In this syringe, the indication that the waiting container is empty is the only alarm.

──────────────────────────────────────────────────続 き Continuation of front page (81) Designated country EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE ), OA (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, KE, LS, MW, SD, SL, SZ, UG, ZW), EA (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY , CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP , KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW (71) Applicant Vihdintie 15, VIHTI, Finland

Claims (19)

[Claims] 1. A device for indicating a dosing act provided with an indicator for registering a dosing act of a drug which can be administered in a regular manner. An apparatus comprising: detecting means (7) provided to detect the mechanical movement of the device; and registration means for registering information on the act of administration in the indicating device (2). 2. The device according to claim 1, which is a separate unit which can be attached to the drug administration unit (1) or in which the drug administration unit can be arranged. 3. Information on the act of administering a dose is registered, and a warning is issued when the detection means (7) detects a mechanical movement relating to a preparatory treatment for administration within a predetermined alert period. Device according to claim 1 or 2, characterized in that it comprises an indicator (5b) provided. 4. An indicator (5b), which is provided so as to continuously and visually indicate, at least for a predetermined period, that information on administration of a substance has been registered. An apparatus according to any one of the preceding claims. 5. Apparatus according to any of the preceding claims, comprising an indicator (5a) provided to provide an alarm at predetermined intervals and to indicate the time of administration of the medicament. . 6. The detection means (7) is provided for detecting a movement of a part of the dosing unit (1), such as a piston or a push button or a dynamically connected part. Apparatus according to any of the preceding claims. 7. The detection means (7) comprises means for moving a part of the indicating device (2) associated with a preparation procedure for administration, a part covering the push button, such as releasing the compression. 6. The method according to claim 1, further comprising:
An apparatus according to any one of 8. The indicating device (2) includes a space in which the dispensing unit (1) is arranged, and the indicating device (2) and the dispensing unit are detachable from each other in connection with a dispensing operation. Apparatus according to any of claims 2 to 5, wherein said detection means (7) are provided to detect removal from each of said dosing unit (1) and said indicating device. . 9. The indicating device (2) is a stand including several places such as a recess (10) for the dosing unit (1), and some detecting means (7) of the stand are Device according to claim 8, characterized in that it is assigned to each dosing unit (1) and is arranged to detect the removal of each dosing unit (1) from its location. 10. An indicator (5a) for each dosing unit (1) programmed to provide an alarm in connection with each dosing unit on the stand or an indicator panel (12) connected to the stand. The apparatus of claim 9 comprising: 11. A system comprising a set of indicators (5a, 5b), wherein a first indicator (5a) is provided to indicate when it is time to administer a dose from the dosing unit (1), The second indicator (5b) is provided to provide a warning or to indicate continuously that the dose has been dispensed from the dosing unit (1) for at least a predetermined period. Apparatus according to any of the preceding claims. 12. The system according to claim 9, further comprising an alarm device provided to trigger an alarm if the dosing unit (1) is not removed from its place at a predetermined time. 12. The apparatus according to 10 or 11. 13. An alarm device is provided for triggering an alarm if the two dosing units (1) are not removed from their location at a predetermined time. The described device. 14. The device according to claim 12, wherein the alarm device is provided to trigger a remote alarm via a communication line. 15. The indication device (2) which is to be made immovable with respect to each other or immobilized after the act of administration has been detected.
Apparatus according to any of the preceding claims, characterized in that it comprises locking means provided to lock the movable part of (1). 16. The method according to claim 1, wherein the medicament dosing unit is a syringe or an injection pen for an injectable dose such as an insulin dose. apparatus. 17. The act of administering a drug that can be regularly administered is performed by an administration unit (1
), The dosing unit (1) is provided with another detachable indicating device (2), which is used to administer the administered substance when administering the administered substance. Is used to detect the mechanical movement of the dosing unit (1) associated with the administration of the substance into the body or with respect to the preparatory treatment for the administration, Is automatically registered in the memory of the pointing device (2) from the detecting means (7). 18. A device for monitoring the administration of a substance to be administered from different administration units (1) according to a predetermined regimen, wherein the use of each administration unit (1) is performed by a memory of an indicating device (2). 18. Automatically registered as
The described method. 19. The method according to claim 17, wherein the method is used to monitor the administration of an insulin dose to be administered at predetermined intervals from an insulin-containing administration unit (1).