US20100236973A1 - Container For a Blister Package - Google Patents
Container For a Blister Package Download PDFInfo
- Publication number
- US20100236973A1 US20100236973A1 US12/087,775 US8777507A US2010236973A1 US 20100236973 A1 US20100236973 A1 US 20100236973A1 US 8777507 A US8777507 A US 8777507A US 2010236973 A1 US2010236973 A1 US 2010236973A1
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- United States
- Prior art keywords
- blister package
- container according
- container
- compliance
- user
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills
- B65D83/0445—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills all the articles being stored in individual compartments
- B65D83/0463—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills all the articles being stored in individual compartments formed in a band or a blisterweb, inserted in a dispensing device or container
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
- A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
- A61J7/0481—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers working on a schedule basis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
- A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
- A61J7/0427—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system
- A61J7/0436—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system resulting from removing a drug from, or opening, a container
Abstract
The present invention provides a container for storing a blister package and for managing medication with a pharmaceutical composition comprised in the blister package. The container comprises a housing which forms a compartment for the blister package, means for indicating towards a user an appropriate time of accessing the blister package, and means for detecting a users access to a blister package in the compartment. The blister package is moved into and out of the compartment by means of an ejection structure to which the blister package may be fixed. The ejection structure facilitates an enhanced handling of the blister package during insertion and removal of the blister package and facilitates a more accurate indication of a user's access to the blister package.
Description
- The present invention relates to a container for a blister package e.g. containing doses of a pharmaceutical composition, the container comprising a housing forming a compartment for the blister package, means for indicating towards a user an appropriate time of taking a dose of the pharmaceutical composition, and means for detecting a user's access to the blister package and thereby access to the pharmaceutical composition.
- A blister package is typically a transparent, moulded piece of plastic forming a cavity or a plurality of cavities which are sealed with a peelable or breakable foil or a sheet of cardboard. Blister packages are typically used to package and display an item of merchandise or for packing doses of pharmaceutical compositions, sweets, chewing gum etc. A blister package is sometimes referred to as a bubble pack.
- In connection with blister packages with pharmaceutical compositions, dispensers and containers exist with timer means for noticing the user when to take a dose. Some of the existing systems automatically record the removal of a dose from a blister package, or record compliance of the removed doses with a prescribed medication plan for the pharmaceutical composition in question. The user may e.g. receive a signal which indicates when to take a dose of the medical composition, or which indicates how much overdue the last dose is.
- WO 03/003970 discloses a method for identifying blister packages with medicaments, and WO 99/43283 discloses a device for indicating an event of administration.
- It is an object of the present invention to improve the existing containers for blister packages. In a first aspect, the invention provides a container of the kind mentioned in the introduction in which the container further comprises an ejection structure or rejection structure to which the blister package can be fixed. “Ejection structure” and “rejection structure” are to be understood as interchangeable expressions in the following specification.
- The ejection structure is movable towards an open position for moving the blister package in an outward direction out of the compartment and movable towards a closed position for moving the blister package in an inward direction into the compartment.
- Since the blister package is moved into, and out of the compartment by the ejection structure which forms part of the container, sliding contact between the container and the blister package during insertion or removal of the blister package from the compartment may be avoided completely. This enables enhanced functioning of the container, e.g. with an improved guiding of the blister package into and out of the compartment and in particular with respect to the use of blister packages of various kinds, sizes and conditions. Due to the guided insertion of the blister package into the compartment, the user may feel more certain about correct positioning of the blister package in the compartment, and sensors for detecting presence of a blister package or a user's access to a blister package may operate more reliably. Furthermore, the avoidance of direct sliding contact between the blister package and the container may increase the protection of the blister package, and unwanted opening and exposure of a dose of a pharmaceutical compound due to wear can be avoided.
- The ejection structure may be guided by sliding contact between a surface of the ejection structure and a surface of the housing, and to improve the ease of movement, matching surfaces could form a sliding bearing or a linear roller bearing. The ejection structure may preferably be guided in the housing by a linear slide allowing a linear movement of the ejection structure relative to the housing, and the position of the ejection structure may preferably be supported by friction between a surface of the ejection structure and a surface of the housing. In one embodiment, the ejection structure moves back and forth in a slot which is dimensioned to receive the blister package—i.e. the compartment is formed by a slot in the housing. To facilitate insertion of the blister package into the slot, the slot may form an opening with a bevelled or chamfered edge which guides the blister package into the slot.
- The linear slide may define an end-stop beyond which further movement of the ejection structure relative to the housing is prevented. Separation of the ejection structure from the housing is thereby prevented.
- User-access to the blister package may be detected e.g. by surveillance of the blister package itself in the device, e.g. by mechanical, optical or other means which is triggered by movement of the blister package itself. Blister packages may, however, be of varying size, type and condition. As an example, the size or shape of the blister packages may be different from blister package to blister package, and some users may already have removed a portion of a blister package before inserting the remaining portion into the compartment. The varying conditions of blister packages render detection of movement of the blister package difficult and inaccurate. In one embodiment of the invention, the user-access is detected by detection of movement of the ejection structure rather than by surveillance of the blister package itself. Accordingly, increased safety in the detection of the user-access may be obtained independent on the type, size and condition of the blister package. The user-access may be detected by any mechanical switching means, by an optical detector, by a magnetically triggered switch or by magnetic-inductive means arranged to detect movement of the ejection structure relative to the housing. As an example, user-access may be determined by a mechanical switch which is embedded in the linear guide, or which is located along the linear guide to be triggered when the ejection structure is moved in the outward or inward direction.
- The user-access may also be detected optically, e.g. by interruption of a beam of electromagnetic radiation, by a magnetically sensitive switch located on one of the housing and the ejection structure or by electrical induction triggered by the movement of the ejection structure relative to the housing.
- User-access may also be registered by manual activation of an alternative registration structure, e.g. a compliance button switch etc.
- To provide a clear indication to the user that the user-access has been recorded, the switch may provide a tactile indication, or indication may be given by means of an electrically or mechanically generated sound.
- In one embodiment, user-access is only registered by movement of the ejection structure in one of the outward and inward directions. As an example, user-access may not be registered upon movement of the ejection structure out of the compartment but only when the ejection structure and thus also the blister package are moved into the compartment.
- In one embodiment, the container is adapted to store a blister package containing doses of a pharmaceutical composition, e.g. pills, tablets, capsules, suppositories, dragees, chewing gums, powder, granule, gels, a liquid etc., e.g. for parenteral use, such as adapted for buccal or sublingual administration. If such a composition is designed for administration at a fixed time interval, in the following refereed to as In accordance with a medication plan“, i.e. not too often or seldom, support may be provided to the user by a compliance structure adapted to indicate a time at which the latest user-access occurred, i.e. when the user gained access to the blister package latest. The compliance structure may further be adapted to provide the duration since last user-access.
- In a more advanced embodiment, the compliance structure contains information relating to a medication plan and automatically alerts the user when it is time to take a dose of the pharmaceutical composition. As an example, the compliance structure could be adapted to switch between an attentive state in which the user is supposed to take a dose of the drug compound, and a non-attentive state in which the user is supposed to wait for the state to change to the attentive state before taking further doses. The switching from the non-attentive state to the attentive state could be triggered by a timer which is programmed in accordance with medication plan for the drug compound in question. The switching from the attentive state to the non-attentive state could be triggered by user-access, e.g. by registration of movement of the ejection structure. User-access may thereby reset the timer which once again counts when the next dose of the pharmaceutical composition is due and switches the container to the attentive state.
- In one embodiment, user-access is only registered when the compliance structure is in the attentive state. When the compliance structure is in the non-attentive state, i.e. when it is not time for the next dose of the pharmaceutical composition, neither movement of the ejection structure, nor manual operation of a push button switch resets the timer which counts the time until the next dose of the pharmaceutical composition is due. In another embodiment, user-access may only be registered, and the timer thus be reset, by manual operation of the push button switch when the compliance structure is in the attentive state. I.e. movement of the ejection structure does not reset the timer. This reduces the electrical consumption of the device if the user moves the blister package into or out of the container when the compliance structure is in the non-attentive state, and the feature thus saves battery and further allows replacement of the blister package without resetting the timer.
- In a more advanced embodiment, the compliance structure is adapted to read a medication plan from the blister package, e.g. by means of any technique for electronic reading known in the art, e.g. magnetically, optically etc. In one embodiment, the container comprises a plurality of reading sensors, e.g. adapted to read individual medication plans for a plurality of doses included in a blister package. In this embodiment, the sensors could also be utilised for recording the history of the medication, e.g. that dose no. 1 was taken at a specific point in time, dose no. 2 at another point in time etc. This feature facilitates documentation of a medication which is based on a number of different doses included in a single blister package.
- The user may indicate a desire for obtaining information relating to the compliance in a very simple way by use of a push button switch. As an example, the user may push a pre-specified number of times, e.g. three times to request information about the state of the compliance structure, i.e. if it is time for a new dose of the pharmaceutical composition or optionally—when it is time for the next dose.
- To indicate towards the user if the ejection structure and thus also the blister package are not in the closed position, the container may further comprise a second timer adapted to determine a period of time in which the ejection structure has not been in the closed position. The compliance structure may be adapted only to switch from the attentive state to the non-attentive state if the timer has determined that the ejection structure has not been in the closed position in a time interval which is longer than a pre-specified time interval.
- The attentive state may be indicated to the user by a notification signal such as a light, sound, or vibration signal, or a combination there between, or the container may even transmit a notification signal by wireless communication, e.g. via Bluetooth™ communication to an external device. Wireless communication of the notification signal facilitates remote surveillance of a patient, e.g. at a hospital or at a home for people who require care.
- The user may not notice the notification signal, e.g. due to noise or other circumstances. In order to save battery or in order not to disturb unnecessarily, the notification signal may be transmitted as repeated signals at pre-specified periods of time after the shift of the compliance structure from the non-attentive state to the attentive state. In one embodiment, the pre-specified period of time increases between each transmission. As an example, one notification signal lasting e.g. 15 seconds may be transmitted once the compliance structure switches to the attentive state, after 5 minutes a subsequent notification signal may be transmitted if the container is still in the attentive state. After e.g. 15 minutes yet another notification signal could be transmitted etc.
- If the user ignores the signal, the container may be adapted, e.g. after a pre-selected number of repeated signals, to shift automatically back to the non-attentive state. In this case, the container may record a non-compliance insignia for that period. According to medication instructions for a specific pharmaceutical composition, a number of subsequent “correct” points in time at which a dose of the pharmaceutical composition is to be taken, i.e. a specific interval between “correct” user-accesses. The container may be adapted for each interval to determine if user-access has been established, i.e. e.g. if the ejection structure has been moved. If the ejection structure has been moved, the container registers “compliance” for the interval, and if not, it registers “non-compliance” for the interval. After a certain amount of intervals, the number of compliances or non-compliances out of a number of intervals may be presented to the user or transmitted via an interface to an external device.
- The number of compliances within a period could be transformed into a more easily understandable identifier of the compliance, e.g. numeral score, or into a signal given by illumination of a light emitting diode (LED) or similar light on an outer surface of the container, e.g. in a accordance with a colour code, or a sound signal may be transmitted in accordance with a code which indicates the number of compliances or non-compliances for a period involving a certain number of intervals.
- As an example, more than one registration of non-compliance out of five may result in a red light signal or a warning tone to be transmitted to the user, whereas one or less non-compliances out of five may result in a green colour, or no warning tone being transmitted to the user. The container could be adapted always to calculate the compliance from a period comprising a fixed number of intervals. I.e. each time a new interval is started, the evaluation of compliance is based on the latest interval and a fixed number of previous intervals. This provides a moving average, i.e. an average over a fixed preceding period of time.
- In one embodiment, the container comprises an interface structure e.g. based on an USB interface etc by which the container may communicate with an external computer system. As an example, the compliance data may be communicated to a computer, e.g. at health centre, in order to monitor the medication and compliance. Alternatively, or additionally, the container could be adapted for wireless communication or it may comprise a memory module which is replaceable, e.g. an SD-memory module of the kind known from electronic appliances. This would allow the user to forward the compliance date to an external computer system e.g. by regular mail.
- To increase the area of visual appearance of a light signal on an outer surface of the container, the light may be generated by illuminating means such as an LED which is arranged to transmit the light transversely into a prism, e.g. a prism which forms part of a front cover of the container. The prism may spread the light and make the signal more easily detectable.
- In one embodiment, the prism may form a shape which indicates the type of drug substance for which the medication instructions are provided and which is comprised in the blister package.
- The blister package could be fixed to the ejection structure by a gripping means comprising two parts forming a slot into which the blister package is inserted. As an example, the gripping means may comprise a back member and an adjacent front member located relative to each other so that a blister card can be received there between. The back member and front member may e.g. be movable relative to each other in a direction towards and away from each other in a manner corresponding to a clip or clothes-pin. The clip-like gripping means may be dimensioned relative to the slot into which the blister package is received so that the back and front members are pressed together by the inner surfaces of the slot.
- In one embodiment, the gripping means is adapted to support a blister package of the kind wherein a number of doses, e.g. tablets or pills are located in individual bulges or cavities in a surface of the blister package. In this embodiment, at least one of the back and front members may comprise a gripping structure adapted at least partly to encircle a portion of one of the bulges in the surface of the blister package. The gripping means may in particular prevent rotation of the blister package during the movement of the ejection structure into and out of the container. As an example, the gripping means may comprise one or more support profiles which extend along one or more outer edges of the blister package and thus prevent rotation of the blister package relative to the ejection structure. The support profiles may e.g. comprise grooves in which the edges of the blister package are received.
- In one embodiment, the container comprises detection means capable of detecting presence of a blister package which is fixed to the ejection structure. As an example, the detection means may alert the user if no blister package is present in the container for a certain amount of time. In another embodiment, the container may comprise detection means capable of determining the content, e.g. the number of doses which remains in a blister package, and to inform the user when a certain level is reached. This will allow the user to procure a new blister package in due time. The detection means could form part of the gripping means. In one embodiment, the detection means is divided into two separate sensors which register the contents of a blister with two rows of doses. In this embodiment, the sensors may e.g. determine the number and locations of doses in each of the two rows of doses.
- The container may be adapted to accommodate further blister packages, e.g. in separate compartments.
- The container may comprise a tearing-off edge along which a portion of the blister package may be torn off. This may e.g. facilitate removal of one single dose or one row of doses from the blister package. For this purpose, the ejection structure moves between different locations which are determined by tactile indications. By movement between two of these locations, one row of doses is moved across the tearing off edge whereby that row of doses may be torn off.
- In one embodiment, the container is shaped so that it can be located in an upright position on a table, e.g. as a frame for a picture with an un-foldable stand on a back surface or like a book which can be unfolded. In the embodiment wherein the container is opened like a book, the opening of the container may register the user-access.
- In one embodiment, the container comprises one single operation button by which various functions may be controlled depending on a number of times the button is operated. As an example, a single activation may indicate user-access, three activations within a certain time, e.g. three activations within 5 seconds may indicate that the user requests data concerning compliance, and a larger number of activations, e.g. 5 may indicate a desire of switching the compliance structure off. In this case, the container may be used as a regular container for storing blister packages.
- Preferably, the ejection structure is in the form of a sheet substantially coplanar with the housing.
- In one embodiment, cover means for covering an opening of the container in a closed condition of the container are provided, the cover means being movable between a closed end position and an open end position, the cover means in the open end position having been rotated about a longitudinal axis of the container in order to form a stand for positioning of the container in an inclined position on a horizontal surface. Preferably, at least part of the movement of the cover means from the closed end position to the open end position actuates movement of the ejection structure from an idle position to an ejected position, and vice versa. These features provide an easy-to-use, very functional and aesthetically appealing container with a cheap structure that can be easily manufactured.
- In a second aspect, the invention provides a container with a compartment for a blister package, and a blister package, said blister package forming at least one row of cavities with doses, the row extending between a first end portion and a second end portion, characterized in that at least one of the end portions and an adjacent cavity cooperate with gripping means of the container to facilitate movement of the blister package into the compartment and out of the compartment. In one embodiment, the blister package comprises a plurality of weakening lines facilitating division of the blister package between each of the cavities whereby the user may tear off a used portion of the blister package when removing a dose. In this embodiment, it is an object not to provide the weakening line between at least one of the end portions and an adjacent cavity. This facilitates that the user can not, by accident, remove that end portion from the blister package, and that end portion may thus serve for engagement with the gripping means of the container.
- In the following, preferred embodiments of the invention will be described in further details with reference to the drawing in which:
-
FIG. 1 shows three different views of a first embodiment of a container according to the present invention, -
FIG. 2 shows a variant of the container ofFIG. 1 with a removable stand, -
FIG. 3 shows a logic flow diagram of the container ofFIG. 1 , -
FIG. 4 shows another variant of the container ofFIG. 1 wherein the second compartment is opened, -
FIG. 5 shows the slots into first and second compartments of the container ofFIG. 1 , -
FIG. 6 shows yet another variant of the container ofFIG. 1 with a tear-off edge for separation of one row of doses from a blister package in the container, -
FIGS. 7 to 9 show three different views of a second embodiment of the container according to the invention,FIG. 10 shows a partial cross section of parts of the embodiment ofFIGS. 7 to 9 , and -
FIG. 10 a shows a detail ofFIG. 10 . -
FIGS. 1 , 2 and 4-6 show a first embodiment of acontainer 1 according to the invention. - As shown in
FIG. 1 , thecontainer 1 of the first embodiment comprises afirst slot 2 forming an opening into a first compartment and asecond slot 3 forming an opening into a second compartment. The first compartment is for storing a first blister package and the second compartment is for storing a second blister package. The first blister package is an active blister package from which a pharmaceutical composition is consumed, and the second blister package is a “spare” blister package which can be moved to the first compartment when the blister package stored in the first compartment is empty. The container comprises ahousing 4, means for indicating towards a user an appropriate time of accessing the blister package, e.g. by means of a sound signal, fixing means 5 for holding the blister package, and means for detecting a users access to a blister package in the compartment. - Insertion and withdrawal of the blister into an out of the first compartment is facilitated by an ejection structure which is operated by the
handle 6 which can slide back and forth on the outer surface of the container and thereby moves the blister package into and out of the compartment. The rejection structure is movable towards an open position for moving the package in an outward direction out of the first compartment and movable towards a closed position for moving the package in an inward direction into the first compartment. When the user moves the rejection structure, the movement is registered as being a users access to the blister package in the first compartment. The rejection structure is attached to the housing via a linear guide providing linear sliding of the rejection structure relative to the housing. - The container comprises a single compliance
push button switch 7 by which the user may activate various functions depending on the number of activations of the switch within a pre-specified period of time. - The container comprises signal transmitting means 8 which transmits a coloured light signal where the colour indicates the compliance of the user, i.e. how many times within a specified period the user has complied with a medication plan. In addition, the container comprises a transmitter to transmit a sound signal which indicates when it is time for a user to take a dose of the pharmaceutical composition in the blister package. In this embodiment, the container shifts from a non-attentive to an attentive state. When the user moves the rejection structure out of the closed position and back into the closed position, i.e. when moving the blister package back into the first compartment after having taken the dose, the container shifts back from the attentive state to the non-attentive state and compliance is registered for the interval in which the dose is taken in accordance with the medication plan.
- To support correct medication, the container has a timer, and the following functions are performed by processing means in the container:
-
- A time which is counted by the timer is reset by registration of user-access to the blister package. In practise this registration is achieved either by moving the rejection structure to an open position and back to the closed position or by a users activation of
compliance button 7. - Alarm is transmitted after a specific period, e.g. after 24 hours when the medication plan prescribes a dose of the pharmaceutical composition once a day.
- Snooze function if dose is not taken after 15 minutes and 30 minutes from the first alarm
- Remind alarm if dose is not taken within 6 hours after first alarm.
- Remind alarm if dose is not taken within 12 hours after first alarm.
- If dose is not taken later within 24 hours+12 hours, a count is set to “out of compliance”
- A time which is counted by the timer is reset by registration of user-access to the blister package. In practise this registration is achieved either by moving the rejection structure to an open position and back to the closed position or by a users activation of
- In addition, the container is adapted to determine interactive compliance as follows:
- “Adherence” is defined as the sum of compliance and persistence
- “Compliance” is taking the medication as prescribed by the medication plan, e.g. once daily.
- “Persistence” is staying on treatment over the whole treatment regiment
- “Compliance time” is defined as 24 hours plus reminder time, max 12 hours (total 24+12=36 hours). Compliance time starts always from default time (start time set by user when resetting the device). “Default time” is defined as the time the user sets as alarm time by pressing compliance button>5 seconds. “Compliance time frame”=“compliance time”−6 hours to “compliance time”+12 hours.
- Example of alarm time (4 times reminding alarm after the first alarm for the worst case)
-
First day XX:XX Default time + Sound 1Second day XX: XX Alarm 2. Not taken (as example) Second day, snooze Alarm 2. Not taken (as example) XX:XX + 15 min Second day, snooze XX:XX + Alarm 2. Not taken (as example)30 min Second day XX:XX + 12 hours Alarm 2. Not taken: Not compliance Taken: Compliance Third day XX: XX Alarm 2. First alarm on default time. Etc. - The device communicates compliance with the user according to the logarithm shown below. The compliance logarithm shall be counted seven days moving average. When restarted/reset the compliance shall start the calculation with a full 7 days compliance in the log. See example below. The numbers below represents the sum of taken tablets during compliance time. Seven days back (if restarted /reset calculating with the fictive seven day full compliance):
-
5-7 days inside compliance (Green) 3-4 days Attention compliance (Orange) 0-2 days Out of compliance (Red)
Example of compliance function - 1=taken tablet inside compliance window
- 0=not taken tablet inside compliance window
- R=Restarted device
- The logarithm starts with
full compliance 7 days back. - The signal transmitting means 8 comprises a light emitting diode (LED). The LED illuminates a prism with a shape which indicates the type of pharmaceutical composition for which the medication plan is programmed in the compliance structure. In the present embodiment, the shape indicates a straw, and the pharmaceutical compound is directed towards allergy against grass. Three-color codes shall be used to signalize compliance: Green, Orange and Red. Green means “Inside compliance”, Orange means “Attention compliance”, and Red means “Out of compliance”.
- The transmitter to transmit a sound is adapted to transmit a sound level at 74 dB with background 65 dB measured 8 inches from the device. Alarm is activated in 30 seconds or recommended action is performed.
- Following alarms/sounds shall be used:
-
Alarm Sound description Comment Alarm/ sound 1xx “Default time set” Two short peeps within 0.5 seconds Alarm 2 xx-xx-xx-xx-xx- “Take a dose” Alarm 3xxx-xxx-xxx-xxx “Push blister package back into the compartment” Alarm 4xx---xx---xx--- “Press compliance button” xx--- - The container is adapted to be operated on
batteries 9. - The container is specifically made for a
blister package 10 comprising twocolumns weekend line 13 at which the row may be torn off from the remaining portion of the blister package. - The gripping structure comprises a front member and a back member which is located on the opposite side of the blister package 10 (not visible in
FIG. 1 ). The front member comprises twoelements -
FIG. 2 shows a variant of the container according to the first embodiment of the invention with aremovable stand 16 which is attachable to the back surface of the container and allows the container to be positioned in an upright position on a table. -
FIG. 3 shows a logic flow diagram. -
FIG. 4 shows another variant of the container according to the first embodiment wherein alid 17 is hinged to thehousing 4 and enables complete opening of one of the compartments, in this case the second compartment. -
FIG. 5 shows theslots enlarged openings 18, 19 and an intermediate portion 20. The slot thus matches the shape of ablister package 10 of the kind disclosed inFIG. 1 , i.e. with two rows with doses, e.g. tablets or pills. -
FIG. 6 shows yet another variant of the container according to the first embodiment with a tear-off edge 21 for separation of onerow 22 of doses from the blister package. In this variant, thehandles 23, 24 for moving the rejection structure and thus the blister package into and out of the compartment is provided with a tactile indication of the locations at which the doses in the blister package is in a correct position relative to the tear-off edge 21, e.g. when a weakened line of the blister package is located adjacent the tear-off edge. -
FIGS. 7 to 10 a show a second embodiment of the container according to the present invention. Similar reference numerals refer to similar elements or elements of the same function as in the embodiment ofFIGS. 1 to 6 . - The
container 1 comprises ahousing 4, which may on its front side shown inFIG. 7 comprise not shown indicating means such as an LED or LCD and/or a compliance structure such as has been described in the above, e.g. in the form of a push button or the like. Thehousing 4 is in the form of a sheet of material, such as plastic, bent to form a compartment for ablister package 10. An ejection structure in the form of anejection sheet 30 is housed inside thehousing 4 in a closed end position of thecontainer 1 shown inFIG. 7 . In an intermediate position shown inFIG. 8 and in an open end position shown inFIG. 9 theejection sheet 30 has been ejected from thehousing 4 to project from the side of thehousing 4.FIG. 10 shows theejection sheet 30 in the ejected position corresponding toFIGS. 8 and 9 , andFIG. 10 a shows a detail of theejection sheet 30 ofFIG. 10 . - The
ejection sheet 30, which is seen best inFIGS. 9 and 10 , has been bent such that afront side 30 b and aback side 30 c lie substantially coplanar with afront side 4 b and aback side 4 c, respectively, of thehousing 4. Acurved connection portion 30 a of theejection sheet 30 abuts a similarly shapedconnection portion 4 a of thehousing 4 in the closed end position of thecontainer 1 shown inFIG. 7 . Theejection sheet 30 comprises a linear slide in the form of aslot 31 engaging a inward facingprojection 32 of thefront side 4 b of thehousing 4 to ensure a smooth and linear movement of theejection sheet 30 between the open and closed end positions of thecontainer 1. Theprojection 32 may form a stop, e.g. in the form of a wider portion (not shown), to ensure that theejection sheet 30 at all times remains attached to thehousing 4. - The
ejection sheet 30 further comprises fixing means in the form of aninsert 33 for securing theblister package 10 to theejection sheet 30. As is shown inFIG. 10 a theinsert 33 comprises two projections, which are able to hold ablister package 10 inserted as shown by means of the arrow ofFIG. 10 a, i.e. a sheet portion of theblister package 10 is forced to enter a secured or fixed position. In the secured or fixed position of the blister package the projections push against each other on either side of the sheet portion of theblister package 10. In a not shown variant of the second embodiment of the invention two blister packages are held in theinsert 33, the second blister package for example being held between one of the projections and a third projection of the insert. - The
ejection sheet 30 comprises arecess 35, which provides a better grip on theblister package 10. - The
back side 30 c of theejection sheet 30 may as an alternative or supplement comprise further fixing means in the form of apertures (not shown) corresponding totablet projections 10 a of theblister package 10 in order to provide an even better attachment of theblister package 10 on theejection sheet 30. In case of ablister package 10 with ten tablet projections the back side would comprise ten correspondingly positioned and shaped apertures. In this variant the projections face theback side 30 c of theejection sheet 30, they may however in other embodiments face the opposite way. In another not shown variant the apertures are provided on a separate sheet positioned to be coplanar with theback side 30 c of theejection sheet 30. - In a not shown variant of the second embodiment of the invention the ejection structure does not comprise the front and back sides 30 b, 30 c. In this variant the
insert 33 in itself pushes theblister package 10 out of the housing during the ejecting movement. However, the shown variant is preferred since the front and back sides 30 b, 30 c provide support for theblister package 10. - Means for detecting when a user gains access to the
container 1 may as examples be provided as a sensor in theinsert 33 or at an end of theprojection 32. - The
container 1 further comprises cover means in the form of acover 34 for covering an opening of thecontainer 1 in a closed condition of thecontainer 1 as is shown inFIG. 7 . As can be seen fromFIGS. 8 and 9 the opening extends from a top edge along a side edge and to a bottom edge of thehousing 4.Parts cover 34 is movable between the closed end position ofFIG. 7 and the open end position ofFIG. 9 , thecover 34 being in the intermediate position ofFIG. 8 between the said two end positions. Thecover 34 is attached to theejection sheet 30 by means of stub shafts (not shown) embedded in correspondingapertures 36 of a side portion of theejection sheet 30. In an alternative not shown variant the stub shafts are replaced by a through-going shaft extending through bothapertures 36. - When wanting to open the
container 1 in order to gain access to a tablet, a user moves thecover 34 from the closed end position ofFIG. 7 to the intermediate position ofFIG. 8 . This may be done by gripping thehousing 4 with one hand and thecover 34 with the other, pulling them away from each other. This provides a linear slide of thecover 34 actuating movement of theejection sheet 30 from its idle position in thehousing 4 by pulling it out of the side edge opening of thehousing 4 by means of the stub shafts. Thehousing 4 is formed such that when thecover 34 andejection sheet 30 enter the intermediate position of thecontainer 1 ofFIG. 8 , thecover 34 is released from the linear slide and is able to rotate about a longitudinal axis of thecontainer 1 defined by the stub shafts. The user then rotates thecover 34 to the second end position shown inFIG. 9 . Now, easy access to theblister package 10 is provided. The user takes out theblister package 10, breaks off or pushes out a tablet, and reinserts theblister package 10 into theinsert 33. In order to close thecontainer 1 an inverse operation is carried out by the user such as to bring thecontainer 1 from the open end position to the closed end position. - In the open end position shown in
FIG. 9 the rotatedcover 34 forms a stand for positioning of thecontainer 1 in an inclined position on a horizontal surface such as a table (not shown). Thecontainer 1 preferably comprises spring means (not shown) or other suitable retaining means known to the skilled person for retaining thecover 34 in the rotated position shown inFIG. 9 such as to not collapse when positioned on said horizontal surface. - In variants of the second embodiment of the invention further spring means may be provided for biasing the
ejection sheet 30 towards the ejected position, such spring means for example being actuated by means of a button or the like.
Claims (32)
1. A container (1) for a blister package, the container comprising:
a housing (4) forming a compartment for the blister package,
means for indicating towards a user an appropriate time of accessing the blister package, and
means for detecting a users access to a blister package in the compartment,
characterised in that the package further comprises an ejection structure to which the blister package may be fixed, the ejection structure (6) being movable towards an open position for moving the package in an outward direction out of the compartment and movable towards a closed position for moving the package in an inward direction into the compartment.
2. A container according to claim 1 , wherein the users access to the blister package in the compartment is detected by detection of movement of the ejection structure relative to the housing.
3. A container according to claim 1 , wherein the ejection structure is attached to the housing via a linear slide allowing a linear movement of the ejection structure relative to the housing.
4. A container according to claim 1 , wherein separation of the ejection structure from the housing is prevented.
5. A container according to claim 1 , further comprising detection means capable of detecting presence of a blister package fixed to the ejection structure.
6. A container according to claim 1 , further comprising a compliance structure adapted to indicate a time at which the user latest gained access to the blister package in the compartment.
7. A container according to claim 6 , wherein the compliance structure is adapted to switch from an attentive state to a non-attentive state upon receiving a user-access registration signal.
8. A container according to claim 7 , wherein the user-access registration signal can be provided by movement of the ejection structure.
9. A container according to claim 8 , wherein the user-access registration signal can only be provided by movement of the ejection structure when the compliance structure is in the attentive state.
10. A container according to claim 7 , wherein the user-access registration signal can be provided by activation of a button.
11. A container according to claim 10 , wherein the user-access registration signal can be provided by activation of a button irrespective of the state of the compliance structure.
12. A container according to claim 7 , further comprising a timer adapted to switch the compliance structure from the non-attentive state to the attentive state after a pre-specified duration in the non-attentive state.
13. A container according to claim 12 , further comprising indicating means for transmitting a notification signal upon shift of the compliance structure from the non-attentive state to the attentive state.
14. A container according to claim 13 , wherein the indicating means transmits a notification at pre-specified periods of time after the shift of the compliance structure from the non-attentive state to the attentive state.
15. A container according to claim 7 , adapted to shift to the non-attentive state after a pre-specified period of time in the attentive state without receiving the registration signal.
16. A container according to claim 1 , further comprising processing means adapted to determine a compliance level indicating a difference between a desired consumption frequency for the substance and a frequency of receipts of the registration signal.
17. A container according to claim 16 , wherein the processing means is adapted, for a plurality of time intervals in each of which a user is supposed to have access to the blister package at least once, to register for each interval a compliance signification when a registration signal has been received in that interval or an out of compliance signification when no registration signal has been received for that interval.
18. A container according to claim 17 , wherein the processing means is adapted to determine a grading level based on the numbers of compliance signification and out of compliance signification in a pre-specified number of succeeding intervals.
19. A container according to claim 18 , wherein the transmitting structure comprises a light emitting diode (LED) arranged to transmit a coloured light and to select a colour out of a plurality of colours based on the grading level.
20. A container according to claim 19 , wherein the LED is arranged to transmit the coloured light transversely into a prism which forms part of a front cover of the container.
21. A container according to claim 20 , wherein the prism comprises a shape which identifies the substance in the blister package.
22. A container according to claim 1 , further comprising a timer adapted to determine a period of time in which the ejection structure has not been in the closed position.
23. A container according to claim 22 , wherein the compliance structure is adapted only to switch from the attentive state to the non-attentive state if the timer has determined that the ejection structure has not been in the closed position in a time interval which is longer than a pre-specified time interval.
24. A container according to claim 1 , wherein fixing means for fixing the blister package to the ejection structure comprises a back member and an adjacent front member, the fixing means being adapted to receive a blister card between the back member and the front member.
25. A container according to claim 24 , wherein the back member and front member are movable relative to each other in a direction towards and away from each other.
26. A container according to claim 24 , wherein at least one of the back and front members comprises a gripping structure adapted at least partly to encircle a protruding portion of the blister package.
27. A container according to claim 1 , further comprising a supplementary compartment for an additional blister card.
28. A container according to claim 1 , wherein the ejection structure is in the form of a sheet (30) substantially coplanar with the housing (4).
29. A container according to claim 1 , further comprising cover means (34) for covering an opening of the container in a closed condition of the container and being movable between a closed end position and an open end position, the cover means (34) in the open end position having been rotated about a longitudinal axis of the container in order to form a stand for positioning of the container in an inclined position on a horizontal surface.
30. A container according to claim 29 , wherein at least part of the movement of the cover means from the closed end position to the open end position actuates movement of the ejection structure from an idle position to an ejected position, and vice versa.
31. A combination comprising a container with a compartment for a blister package and a blister package, said blister package forming at least one row of cavities with doses of a pharmaceutical composition, the row extending between a first end portion and a second end portion, characterized in that at least one of the end portions and an adjacent cavity cooperate with gripping means of an ejection structure adapted to move the blister package into or out of the container.
32. A combination according to claim 31 , wherein the blister package comprises a plurality of weakening lines facilitating division of the blister package between each of the cavities whereby the user may tear off a used portion of the blister package when removing a dose.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/087,775 US20100236973A1 (en) | 2006-01-18 | 2007-01-18 | Container For a Blister Package |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75962106P | 2006-01-18 | 2006-01-18 | |
DKPA200600079 | 2006-01-18 | ||
DKPA200600079 | 2006-01-18 | ||
PCT/DK2007/050003 WO2007082543A1 (en) | 2006-01-18 | 2007-01-18 | A container for a blister package |
US12/087,775 US20100236973A1 (en) | 2006-01-18 | 2007-01-18 | Container For a Blister Package |
Publications (1)
Publication Number | Publication Date |
---|---|
US20100236973A1 true US20100236973A1 (en) | 2010-09-23 |
Family
ID=36917273
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/087,775 Abandoned US20100236973A1 (en) | 2006-01-18 | 2007-01-18 | Container For a Blister Package |
US13/494,847 Abandoned US20130008818A1 (en) | 2006-01-18 | 2012-06-12 | Container for a blister package |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/494,847 Abandoned US20130008818A1 (en) | 2006-01-18 | 2012-06-12 | Container for a blister package |
Country Status (6)
Country | Link |
---|---|
US (2) | US20100236973A1 (en) |
EP (1) | EP1973512B1 (en) |
CN (1) | CN101384237B (en) |
CA (1) | CA2637212A1 (en) |
HK (1) | HK1126955A1 (en) |
WO (1) | WO2007082543A1 (en) |
Cited By (1)
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US20160176617A1 (en) * | 2013-08-06 | 2016-06-23 | Westrock Mwv, Llc | Smart dispensing packaging system |
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WO2009000890A2 (en) * | 2007-06-27 | 2008-12-31 | N.V. Organon | Medication container |
US7607538B2 (en) | 2007-08-27 | 2009-10-27 | Schering-Plough Healthcare Products, Inc. | Container for transporting a blister package |
US8061513B2 (en) | 2008-08-21 | 2011-11-22 | Very Special Hearts, LLC | USB flash drive with integrated medication holder |
US20180243171A1 (en) * | 2015-02-27 | 2018-08-30 | Westrock Mwv, Llc | Packages with monitoring devices |
WO2017093198A1 (en) | 2015-11-30 | 2017-06-08 | Sanofi-Aventis Deutschland Gmbh | Packaging assembly |
MX2018006652A (en) | 2015-11-30 | 2019-06-20 | Sanofi Aventis Deutschland | Packaging assembly with mounting attachment. |
WO2018154033A1 (en) | 2017-02-24 | 2018-08-30 | Sanofi | Packaging assembly |
US11565034B2 (en) | 2017-02-24 | 2023-01-31 | Sanofi | Packaging assembly |
USD841158S1 (en) | 2017-10-04 | 2019-02-19 | West Pharmaceutical Services, Inc. | Container lid |
USD841805S1 (en) | 2017-10-04 | 2019-02-26 | West Pharmaceutical Services, Inc. | Container lid |
USD841157S1 (en) | 2017-10-04 | 2019-02-19 | West Pharmaceutical Services, Inc. | Container and lid |
US10842300B2 (en) * | 2018-04-19 | 2020-11-24 | Carl Reid | Mountable container |
DE102019133076A1 (en) * | 2019-12-04 | 2021-06-10 | Aesculap Ag | Composite packaging for easier aseptic presentation of medical products |
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Also Published As
Publication number | Publication date |
---|---|
EP1973512A1 (en) | 2008-10-01 |
WO2007082543A1 (en) | 2007-07-26 |
US20130008818A1 (en) | 2013-01-10 |
HK1126955A1 (en) | 2009-09-18 |
CN101384237B (en) | 2012-08-22 |
CN101384237A (en) | 2009-03-11 |
EP1973512B1 (en) | 2012-10-17 |
CA2637212A1 (en) | 2007-07-26 |
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AS | Assignment |
Owner name: ALK-ABELLO A/S, DENMARK Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:AHAG, ULF;BLOM, ULF;SIOUSTIS, GEORGE;SIGNING DATES FROM 20080819 TO 20080828;REEL/FRAME:021627/0233 |
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STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |