JP2002370906A - Industrial antimicrobial agent composition and antimicrobial method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an industrial antimicrobial composition having a strongly antimicrobial power which has been insufficient in a conventional combination so as to control microorganism and to provide an antimicrobial method. SOLUTION: This industrial antimicrobial composition is characterized by comprising glutaraldehyde, o-phthalaldehyde and 2-methyl-4-isothiazolin-3-one. This antimicrobial method comprises using these active ingredients.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an industrial antibacterial composition and an antibacterial method for controlling microbial contamination of industrial aqueous compositions and the like.

[0002]

2. Description of the Related Art Aqueous industrial compositions based on water, such as aqueous paints, aqueous inks, paper coating liquids, emulsions, latexes, starch slurries, starch paste liquids, inorganic slurries, etc., are contaminated by bacteria. As a result, rot occurs, causing deterioration of physical properties such as generation of odor, decrease in viscosity, and fluctuation in pH, and clogging and coloring of the strainer due to propagation of fungi (filamentous fungi). Also, in the papermaking process in the pulp and paper industry, a large amount of water is used to produce paper, and various organic substances necessary for producing paper are dispersed and dissolved in the water. Like industrial water-based compositions, they are susceptible to contamination by bacteria and fungi. These bacteria and fungi produce mucus metabolites, take in papermaking materials such as pulp and fillers that are dispersed during the papermaking process, and form slime on walls and flow boxes in chests where water flows. . The slime gradually increases and is gradually released, and is made into paper together with papermaking raw materials such as pulp, and appears as foreign matter on the paper. The foreign matter causes quality deterioration, and the foreign matter causes paper breakage, thereby reducing productivity. In industrial cooling water systems,
Recycling of water also causes microorganisms to propagate and form slime, clogging the cooling water system and adhering to the surfaces of heat exchangers and packing, causing a decrease in thermal efficiency.

[0003] Various chemicals have been used as antibacterial agents to prevent microbial contamination of industrial aqueous compositions, papermaking process waters, and industrial cooling water. For example, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4
Thiazoline compounds such as -isothiazolin-3-one, 1,2-benzisothiazolin-3-one and 2-bromo-
2-nitropropane-1,3-diol, 2,2-dibromo-2-nitroethanol, 2,2-dibromo-3-
Bromine compounds such as nitrilopropionamide, organic sulfur compounds such as 4,5-dichloro-1,2-dithiol-3-one and methylenebisthiocyanate, and aldehyde compounds such as glutaraldehyde and orthophthalaldehyde have been used.

[0004] However, long-term continuous use of a single drug tends to cause emergence of resistant bacteria, and thus various antibacterial agents having a combination of two or three components have been used in the past. For example, a combination of two components is disclosed in
Numerous disclosures include a combination of glutaraldehyde with 5-chloro-2-methyl-4-isothiazolin-3-one and the like in 234860 and a combination of glutaraldehyde with methylenebisthiocyanate in JP-B-7-2605. The combination of the three components includes 2,2-dibromo-3-nitrilopropionamide, 4,5-dichloro-1,2-dithiol-3-one and 5-chloro-2-methyl-4 described in JP-A-7-187920. -Isothiazolin-3-one, JP-A-7-25
No. 708, a combination of 2,2-dibromo-3-nitrilopropionamide, methylenebisthiocyanate and 2,2-dibromo-2-nitroethanol. These combinations have a good effect on industrial water-based compositions, papermaking process water and industrial cooling water in which a single agent has been used for a long period of time. As a general means of controlling microorganisms, resistant bacteria have emerged after long-term use even in combination, and there has been a demand for a drug that is effective at a low concentration and has a further effect.

[0005]

DISCLOSURE OF THE INVENTION The present invention provides a drug effective against a wide range of microorganisms having a strong antibacterial activity, which was insufficient with conventional combinations, in order to meet the above demands. It is in.

[0006]

According to the present invention, in order to solve the problems, effects of combinations of various components have been confirmed, and as a result of intensive studies, glutaraldehyde, orthophthalaldehyde and 2-methyl-4-methyl-4-aldehyde have been confirmed. An industrial antibacterial composition characterized by containing three kinds of active ingredients of isothiazolin-3-one is a very excellent antibacterial composition having good bactericidal and bacteriostatic properties even at a low concentration. I found it. That is, the present invention provides an industrial antibacterial composition characterized by containing three kinds of active ingredients of glutaraldehyde, orthophthalaldehyde and 2-methyl-4-isothiazolin-3-one. It is a very excellent antibacterial composition having power, and it is an excellent antibacterial method to add 1 to 20,000 ppm of these three active ingredients to an industrial water-based composition or papermaking process water or industrial cooling water. I found that.

In the antibacterial method of the present invention, an antibacterial composition containing the above three kinds of active ingredients may be added, or the above three kinds of active ingredients may be added separately.

The method of adding the active ingredient of the present invention to an industrial water-based composition, papermaking process water, or industrial cooling water may be a separate or formulated mixture, and a solvent, a surfactant, etc. used in the formulation. Is not particularly limited. However, since industrial water-based compositions, papermaking process water, and industrial cooling water that cause the growth of microorganisms are mainly water-based compositions,
The solvent is desirably relatively hydrophilic.

Examples of the solvent include glycol solvents such as ethylene glycol, propylene glycol, diethylene glycol, triethylene glycol, dipropylene glycol, hexylene glycol, and polyethylene glycol; and glycols such as diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, and diethylene glycol monobutyl ether. Ether solvents, propylene carbonate, dimethylacetamide, dimethylsulfoxide, water and the like can be used. These may be used alone or in combination of two or more types, as long as there is an added amount capable of dissolving three types of active ingredients.

The surfactant may or may not be used. When used, any of a nonionic surfactant, an anionic surfactant, a cationic surfactant and a zwitterionic surfactant is used. It doesn't matter.

[0011]

EXAMPLES Next, the present invention will be described with reference to examples and comparative examples, but the present invention is not limited to these examples.
All the compounding ratios shown in the following table are% by weight. Further, the antimicrobial compositions of the respective examples were prepared by ordinary stirring at room temperature at the indicated ratios of the respective components shown in the respective examples.

Examples 1 to 3 The antibacterial compositions shown in Table 1 were prepared, and their performance was examined by Test Examples 1 and 2. The indication of the active ingredients in the table is represented by the following abbreviations.

Glutaraldehyde: GLA orthophthalaldehyde: OPA 2-methyl-4-isothiazolin-3-one: MIT

[0014]

[Table 1] Table 1 Example

Comparative Examples 1 to 6 The antibacterial compositions shown in Table 2 were prepared and tested in Test Examples 1 and 2,
The performance was examined by

[0016]

[Table 2] Table 2 Comparative Example

Test Example 1 Preservative test of starch slurry "Test method" 10% of cationized tapioca starch by a certain company
A slurry (pH 6.2) was prepared, 30 g was dispensed into a sterilized polypropylene bottle, a predetermined amount of each drug was added, and then a starch slurry (previously spoiled) (number of bacteria: 8.1 × 10
⁷ / ml) was inoculated at 1%. This is sealed under static conditions.
The cells were cultured at 0 ° C., and the number of viable cells over time was measured by a TGC agar plate pour method to determine the antibacterial effect. After the viable cell count, 1% of the spoiled starch slurry was inoculated every week. "Test results" The test results were determined according to the following criteria, and the test results are shown in Table 3. Number of bacteria in 1 ml (number)-: less than 10 ² +: 10 ² or more and less than 10 ⁴ ++: 10 ⁴ or more and less than 10 ⁶ ++++: 10 ⁶ or more and less than 10 ⁷ +++++: 10 ⁷ or more As described above, the evaluation results on the 28th day of the preparations containing one active ingredient in Comparative Examples 1 to 3 and the preparations containing two active ingredients in Comparative Examples 4 to 6 were ++ to ++++. On the other hand, the evaluation results of the preparations containing the three kinds of active ingredients of Examples 1 to 3 are-to ++, and the preparations of the three kinds of the active ingredients are mixed as compared with the preparations of each of the active ingredients alone or two kinds of the mixture. It was confirmed that the product exhibited a remarkable antibacterial effect on starch slurry.

[0018]

Table 3 Antibacterial evaluation of starch slurry

Test Example 2 Preservative test of latex "Test method" A certain company styrene butadiene latex (pH
6.8) was collected, 30 g was dispensed into a sterilized polypropylene bottle, and a predetermined amount of the drug was added thereto. Then, latex (bacterium count: 7.2 × 10 ⁷ cells / ml) which had been putrefactive in advance was inoculated.
This was cultured at 30 in the sealed stationary condition, and the antibacterial effect was determined by measuring the number of viable cells over time by TGC agar plate pour method. After measuring the number of viable bacteria, putrefused latex was added to 1
Inoculated 1% weekly. "Test Results" The results are shown in Table 4 in accordance with the results of the determination of Test Example 1. [Discussion] As shown in Table 3, the evaluation results on the 28th day of the preparations containing one active ingredient in Comparative Examples 1 to 3 and the two active ingredients in Comparative Examples 4 to 6 were obtained. + To ++++, whereas the first embodiment
The evaluation results of the preparations containing the three types of active ingredients are as follows:
++, it was confirmed that the preparation of the three kinds of active ingredients showed a remarkable antibacterial effect on latex as compared with the preparation of each of the active ingredients alone or in combination of two kinds.

[0020]

Table 4 Antibacterial evaluation for latex

[0021]

As described above, when the present invention is applied, the present invention provides an industrial antibacterial composition or an antibacterial method having a strong antibacterial activity, which was insufficient with the conventional single or combination of two. Is possible.

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Claims (2)

[Claims] 1. An industrial antibacterial composition comprising glutaraldehyde, orthophthalaldehyde and 2-methyl-4-isothiazolin-3-one. 2. An antibacterial method comprising adding the industrial antibacterial composition according to claim 1 to an industrial waterborne composition, papermaking process white water, or industrial cooling water.