JP2002348242A - Agent for improving intestinal bacterial flora and composition for improving intestinal bacterial flora containing agent for improving intestinal bacterial flora - Google Patents
Agent for improving intestinal bacterial flora and composition for improving intestinal bacterial flora containing agent for improving intestinal bacterial floraInfo
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- JP2002348242A JP2002348242A JP2001156974A JP2001156974A JP2002348242A JP 2002348242 A JP2002348242 A JP 2002348242A JP 2001156974 A JP2001156974 A JP 2001156974A JP 2001156974 A JP2001156974 A JP 2001156974A JP 2002348242 A JP2002348242 A JP 2002348242A
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- Prior art keywords
- bacterial flora
- glucoside
- intestinal bacterial
- ethyl
- improving intestinal
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Tea And Coffee (AREA)
- Jellies, Jams, And Syrups (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、腸内菌叢改善剤及
び該腸内菌叢改善剤を含有する腸内菌叢改善物に関し、
詳しくは清酒中に含まれるエチル-α-グルコシドのビフ
ィズス菌及び乳酸菌の増殖促進効果、ウェルシュ菌や大
腸菌、ブドウ球菌などの増殖阻害を利用した腸内菌叢改
善剤及び該腸内菌叢改善剤を含有する腸内菌叢改善物に
関する。TECHNICAL FIELD The present invention relates to an intestinal flora improving agent and an intestinal flora improving product containing the intestinal flora improving agent.
Specifically, an intestinal flora improving agent and an intestinal flora improving agent utilizing the growth-promoting effect of ethyl-α-glucoside contained in sake on the growth of bifidobacteria and lactic acid bacteria, growth inhibition of welsh bacteria, Escherichia coli, staphylococci, etc. The present invention relates to an intestinal flora-improved product containing:
【０００２】[0002]
【従来の技術】ヒトの腸内には様々な微生物が混在して
おり、全体で菌叢と呼ばれる一種の生態系を構成してい
る。この腸内菌叢を構成する微生物は、代表的なもので
約120種類にも及び全腸内での総数は100兆個にも達す
る。2. Description of the Related Art Various microorganisms are mixed in the human intestine, and constitute a kind of ecosystem called a flora as a whole. The microorganisms that constitute this intestinal flora are representative, about 120 kinds, and the total number in the whole intestine reaches 100 trillion.
【０００３】腸内環境では、これらの腸内細菌が拮抗関
係を保ちながら、宿主であるヒトの健康と密接な関連を
とっており、正と負の様々な影響を及ぼすことが知られ
ている。その中でもビフィズス菌や乳酸菌は、善玉菌と
呼ばれヒトの健康に寄与していると考えられている。In the intestinal environment, these intestinal bacteria are closely related to the health of the host, while maintaining an antagonistic relationship, and are known to have various positive and negative effects. . Among them, bifidobacteria and lactic acid bacteria are called good bacteria and are considered to contribute to human health.
【０００４】ビフィズス菌は下痢症、便秘症、感染症等
の予防、治療効果や悪玉菌と呼ばれる腸内の有害細菌の
増殖抑制作用等を有し、乳酸菌は乳酸等の有機酸を産生
して腸内を酸性とし、同じく悪玉菌であるウェルシュ菌
や大腸菌、ブドウ球菌などの有益ではない微生物が成育
し難い環境を保つことでヒトの健康維持に役立ってい
る。Bifidobacterium has a preventive and therapeutic effect on diarrhea, constipation, infectious diseases, etc., and an inhibitory effect on the growth of harmful bacteria in the intestine called bad bacteria, and lactic acid bacteria produce organic acids such as lactic acid. By making the intestine acidic, it also helps maintain human health by maintaining an environment in which non-useful microorganisms such as welsh bacteria, Escherichia coli, and staphylococci are also difficult to grow.
【０００５】[0005]
【発明が解決しようとする課題】従って、ヒトの健康維
持を図るための方法として、腸内菌叢の改善を行うこと
が有効であるが、そのためには善玉菌であるビフィズス
菌や乳酸菌にとって腸内で最も不足している栄養素と考
えられる炭素源を補うことが必要である。Therefore, as a method for maintaining human health, it is effective to improve the intestinal flora. For that purpose, it is necessary to improve the intestinal flora such as bifidobacteria and lactic acid bacteria, which are good bacteria. It is necessary to supplement the carbon sources considered to be the most lacking nutrients in the country.
【０００６】しかしながら、通常ヒトが食物として経口
摂取した炭素源は大部分が大腸に達する以前の小腸で消
化吸収されてしまうため、この様な目的のための栄養源
としては、一般に難消化性であることが望まれる。[0006] However, most carbon sources orally ingested by humans as food are mostly digested and absorbed in the small intestine before reaching the large intestine. It is desirable.
【０００７】このようなニーズの下、従来よりビフィズ
ス因子はオリゴ糖類やカゼイン加水分解物やある種の微
生物代謝産物など数多くの物質が報告されており、食生
活文化の向上拡大とともに、より多くの善玉菌増殖因子
の開発が進められている。Under these needs, many substances such as oligosaccharides, casein hydrolysates, and certain microbial metabolites have been reported as bifidobacteria. The development of good bacterial growth factors is underway.
【０００８】そこで、本発明は、清酒中に含まれるエチ
ル-α-グルコシドの腸内菌叢改善効果に着目して、エチ
ル-α-グルコシドを利用した腸内菌叢改善剤及び該腸内
菌叢改善剤を含有する腸内菌叢改善物を提供することを
目的とする。Accordingly, the present invention focuses on the effect of ethyl-α-glucoside contained in sake on improving the intestinal flora, and provides an intestinal flora improving agent utilizing ethyl-α-glucoside and the intestinal flora improving agent. It is intended to provide an intestinal flora improving substance containing a flora improving agent.
【０００９】[0009]
【課題を解決するための手段】本発明者らは、腸内菌叢
改善を進めるための物質を見出すべく鋭意研究を行った
結果、清酒中に存在する糖質であるエチル-α-グルコシ
ドがビフィズス菌や乳酸菌などの善玉菌を増殖促進し、
一方で、ウェルシュ菌や大腸菌、ブドウ球菌などの悪玉
菌に資化されにくい腸内菌叢改善効果を有する物質であ
ることを見出し、本発明を完成するに至った。Means for Solving the Problems The inventors of the present invention have conducted intensive studies to find a substance for improving the intestinal flora, and as a result, it has been found that ethyl-α-glucoside, which is a saccharide present in sake, is not found. Promotes the growth of good bacteria such as bifidobacteria and lactic acid bacteria,
On the other hand, they have found that the substance is a substance having an intestinal flora-improving effect that is hardly assimilated by bad bacteria such as C. perfringens, Escherichia coli, and staphylococci, and have completed the present invention.
【００１０】すなわち、本発明は、エチル-α-グルコシ
ドよりなる腸内菌叢改善剤及びエチル-α-グルコシドを
腸内菌叢改善剤として含有することを特徴とする腸内菌
叢改善物を提供するものである。That is, the present invention provides an intestinal flora improver comprising ethyl-α-glucoside and an intestinal flora improver comprising ethyl-α-glucoside as an intestinal flora improver. To provide.
【００１１】本発明の有効成分であるエチル-α-グルコ
シドは、清酒中に含まれ、これより抽出することもでき
るし、あるいは、微生物由来の酵素α-グルコシダーゼ
の糖転移活性あるいは縮合活性により生成することもで
きるし、又は、化学合成等により得ることもできる。Ethyl-α-glucoside, which is an active ingredient of the present invention, is contained in sake and can be extracted therefrom, or can be produced by the transglycosylation or condensation activity of a microorganism-derived enzyme α-glucosidase. Or it can be obtained by chemical synthesis or the like.
【００１２】ここで、上記微生物としては、Aspergillu
s属、Mucor属、Rhizopus属、Penicillium属、Mortierel
la属、Thermoascus属のカビ、Saccharomyces属、Candid
a属の酵母、Bacillus属の細菌などが使用できる。Here, the microorganisms include Aspergillus
s , Mucor , Rhizopus , Penicillium , Mortierel
La genus, Mold of Thermoascus genus, Saccharomyces genus, Candid
a genus of yeast, such as Bacillus bacteria of the genus can be used.
【００１３】ここで、本発明に係わるエチル-α-グルコ
シドが、腸内菌叢の改善にどの様に係わるかを調べる実
験を行って検討した。Here, an experiment was conducted to examine how the ethyl-α-glucoside according to the present invention is involved in improving the intestinal flora.
【００１４】実験に関する詳細は後に掲げる実験例１で
述べるが、エチル-α-グルコシドが、各種腸内細菌によ
って炭素源として資化されるかどうかを調べ、ビフィズ
ス菌や乳酸菌のような善玉菌によく資化され、ウェルシ
ュ菌や大腸菌、ブドウ球菌のような悪玉菌にほとんど資
化されないという結果を得た。The details of the experiment will be described later in Experimental Example 1. It was examined whether ethyl-α-glucoside could be assimilated as a carbon source by various intestinal bacteria, and it was determined that good bacteria such as bifidobacteria and lactic acid bacteria were used. It was well assimilated and hardly assimilated by bad bacteria such as C. perfringens, E. coli, and staphylococci.
【００１５】つまり、本発明に係わるエチル-α-グルコ
シドは以下の作用を奏する。 （１）ビフィズス菌や乳酸菌などの腸内の善玉菌の増殖
を促進する。 （２）ウェルシュ菌や大腸菌、ブドウ球菌などの腸内の
悪玉菌の増殖を抑制する。That is, the ethyl-α-glucoside according to the present invention has the following effects. (1) Promote the growth of good bacteria in the intestine such as bifidobacteria and lactic acid bacteria. (2) Suppress the growth of bad bacteria in the intestine such as C. perfringens, Escherichia coli, and Staphylococcus.
【００１６】従って、優れた腸内菌叢改善剤として利用
できることになる。Therefore, it can be used as an excellent intestinal flora improving agent.
【００１７】また、このような優れた腸内菌叢改善機能
を有するので、腸内菌叢改善効果を有する素材として食
品開発を進めていくことにより、様々な食品等に利用で
きることになる。Further, since it has such an excellent intestinal flora improving function, it can be used for various foods and the like by promoting food development as a material having an intestinal flora improving effect.
【００１８】[0018]
【発明の実施の形態】次に、本発明に係わる腸内菌叢改
善剤及び該腸内菌叢改善剤を含有する腸内菌叢改善物の
実施の形態を、その作用を検出する実験例を中心に説明
する。BEST MODE FOR CARRYING OUT THE INVENTION Next, an embodiment of an intestinal flora improving agent and an intestinal flora improving product containing the intestinal flora improving agent according to the present invention will be described with reference to an experimental example for detecting the action thereof. This will be mainly described.
【００１９】まず、エチル-α-グルコシドを生成した。First, ethyl-α-glucoside was produced.
【００２０】生成方法については、既に説明したので、
重複した説明は省略する。Since the generation method has already been described,
Duplicate description is omitted.
【００２１】次に、この生成したエチル-α-グルコシド
を使用して以下の実験を行った。Next, the following experiment was conducted using the produced ethyl-α-glucoside.
【００２２】[0022]
【実験１】 エチル-α-グルコシドの各種腸内細菌によ
る資化性試験エチル-α-グルコシドが、ヒトの腸内細菌
によって炭素源として資化されるかどうかを以下の方法
で調べた。[Experiment 1] Ethyl-α-glucoside assimilation test by various intestinal bacteria Whether ethyl-α-glucoside was assimilated as a carbon source by human intestinal bacteria was examined by the following method.
【００２３】供試菌として、通常ヒトの腸内環境に存在
する細菌である、Bacteroides属、Bifidobacterium属、
Clostridium属（ウェルシュ菌を含む）、Eubacterium属
、Fusobacterium属 、Lactobacillus属 の細菌、及び
大腸菌Escherichia coli、ブドウ球菌Staphylococcus a
ureus、その他を用いた。 Bacteroides , Bifidobacterium , Bacteroides , Bifidobacterium ,
Bacteria of the genus Clostridium (including C. perfringens), Eubacterium , Fusobacterium , Lactobacillus , and Escherichia coli , Staphylococcus a
ureus and others were used.
【００２４】培地は、Pepton Yeast Fildes solution
（PYF）液体培地に、グルコース及びエチル-α-グルコ
シドを最終濃度0.5%になるように添加し、115℃,20min
オートクレーブ滅菌後用いた。The medium is Pepton Yeast Fildes solution
(PYF) Glucose and ethyl-α-glucoside are added to a liquid medium to a final concentration of 0.5%, and the mixture is heated at 115 ° C. for 20 minutes.
Used after autoclave sterilization.
【００２５】供試菌株をBL寒天平板で純粋培養し、Fild
es solution加GAM半流動寒天培地、37℃24時間培養で植
え継いだ。The test strain was purely cultured on a BL agar plate.
GAM semi-fluid agar medium with es solution was subcultured at 37 ° C. for 24 hours.
【００２６】この培養液をPYF培地1.5mlに0.03ml接種
し、37℃4日間（96時間）嫌気培養後、pHを測定した。0.03 ml of this culture was inoculated into 1.5 ml of PYF medium, and the pH was measured after anaerobic culture at 37 ° C. for 4 days (96 hours).
【００２７】嫌気培養は、嫌気性インキュベーター（SA
NYO/FORMA社製）を用い、雰囲気はCO210%、H210%、N2バ
ランスの混合ガスを用いた。Anaerobic culture is performed in an anaerobic incubator (SA).
NYO / FORMA), and the atmosphere used was a mixed gas of 10% CO 2, 10% H 2 , and N 2 balance.
【００２８】なお、資化性の判定は、pHがどれだけ低下
したかで資化性の有無、又は強弱を判定した。The assimilability was determined by ascertaining the presence or absence or strength of assimilability based on how much the pH dropped.
【００２９】判定基準は以下の通り。The criteria are as follows.
【００３０】 [0030]
【００３１】最終pHによる資化性の判定結果を表１に示
す。Table 1 shows the results of determination of assimilation based on the final pH.
【００３２】[0032]
【表１】 [Table 1]
【００３３】表１の結果から明らかなように、エチル-
α-グルコシドはビフィズス菌や乳酸菌などの善玉菌に
炭素源としてよく資化される一方で、ウェルシュ菌や大
腸菌、ブドウ球菌などの悪玉菌にほとんど資化されにく
いことが判明した。As is clear from the results in Table 1, ethyl-
It has been found that α-glucoside is often assimilated by good bacteria such as bifidobacteria and lactic acid bacteria as a carbon source, but hardly assimilated by bad bacteria such as welsh bacteria, Escherichia coli and staphylococci.
【００３４】以上より、エチル-α-グルコシドは以下の
作用を有することが分かる。 （１）ビフィズス菌や乳酸菌などの腸内の善玉菌の増殖
を促進する。 （２）ウェルシュ菌や大腸菌、ブドウ球菌などの腸内の
悪玉菌の増殖を抑制する。From the above, it can be seen that ethyl-α-glucoside has the following effects. (1) Promote the growth of good bacteria in the intestine such as bifidobacteria and lactic acid bacteria. (2) Suppress the growth of bad bacteria in the intestine such as C. perfringens, Escherichia coli, and Staphylococcus.
【００３５】従って、エチル-α-グルコシドは、腸内菌
叢改善剤としての効果を有することが分かる。Therefore, it can be seen that ethyl-α-glucoside has an effect as an intestinal flora improving agent.
【００３６】また、エチル-α-グルコシドは、上記のご
とく、腸内菌叢改善機能を有するので、下記実施例に示
すように腸内菌叢改善機能を有する食品の開発に使用で
きることができる。Ethyl-α-glucoside has an intestinal flora improving function as described above, and therefore can be used for the development of a food having an intestinal flora improving function as shown in the following Examples.
【００３７】[0037]
【実施例１】 エチル-α-グルコシドを配合したゼリー
菓子の製造 エチル-α-グルコシドを用いた食品開発の実施例として
ゼリー菓子を製造した。Example 1 Production of jelly confection containing ethyl-α-glucoside Jelly confection was produced as an example of food development using ethyl-α-glucoside.
【００３８】[0038]
【表２】 [Table 2]
【００３９】表２に示すように、果汁に対して約１％の
割合でエチル-α-グルコシドを配合した。As shown in Table 2, about 1% of the fruit juice was mixed with ethyl-α-glucoside.
【００４０】このようにして得られたエチル-α-グルコ
シドを配合したゼリー菓子は優れた腸内菌叢改善効果を
有するものと思われる。It is considered that the jelly confection containing the ethyl-α-glucoside thus obtained has an excellent intestinal flora improving effect.
【００４１】[0041]
【実施例２】 エチル-α-グルコシドを配合した紅茶飲
料の製造 次に、エチル-α-グルコシドを用いた食品開発の実施例
として紅茶飲料を製造した。Example 2 Production of Black Tea Drink Containing Ethyl-α-Glucoside Next, a black tea beverage was manufactured as an example of food development using ethyl-α-glucoside.
【００４２】[0042]
【表３】 [Table 3]
【００４３】表３に示すように、終濃度0.5％の割合で
エチル-α-グルコシドを配合した。As shown in Table 3, ethyl-α-glucoside was blended at a final concentration of 0.5%.
【００４４】このようにして得られたエチル-α-グルコ
シドを配合した紅茶飲料は優れた腸内菌叢改善効果を有
するものと思われる。The black tea beverage containing the ethyl-α-glucoside thus obtained is considered to have an excellent intestinal flora improving effect.
【００４５】[0045]
【発明の効果】以上説明したように、本発明に係わるエ
チル-α-グルコシドよりなる腸内菌叢改善剤は、 （１）ビフィズス菌や乳酸菌などの腸内の善玉菌の増殖
を促進する。 （２）ウェルシュ菌や大腸菌、ブドウ球菌などの腸内の
悪玉菌の増殖を抑制する。 という腸内菌叢を改善する機能を有するので、優れた腸
内菌叢改善効果を有する。As described above, the intestinal flora improving agent comprising ethyl-α-glucoside according to the present invention (1) promotes the growth of good bacteria in the intestine such as bifidobacteria and lactic acid bacteria. (2) Suppress the growth of bad bacteria in the intestine such as C. perfringens, Escherichia coli, and Staphylococcus. Therefore, it has an excellent intestinal flora improving effect.
【００４６】また、このような優れた腸内菌叢改善効果
を有するエチル-α-グルコシドを含有させて腸内菌叢改
善物を構成すると、同じく優れた腸内菌叢改善効果を有
する。Further, when an intestinal flora-improved product is constituted by containing ethyl-α-glucoside having such an excellent intestinal flora-improving effect, the same intestinal flora-improving effect is also obtained.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ２３Ｌ 1/06 Ａ２３Ｌ 1/06 ４Ｃ０８６ Ｃ０７Ｈ 15/04 Ｃ０７Ｈ 15/04 Ａ (72)発明者 古谷 祐治 広島県福山市箕沖町95番地７ 池田食研株 式会社内 Ｆターム(参考） 4B018 LB01 LB08 MD42 MD90 ME09 ME11 ME14 MF12 4B027 FB13 FC06 FK04 FP85 4B041 LC10 LD02 LK09 LK44 4B064 AF01 CA02 CA21 CB30 CD06 CD09 DA01 DA10 4C057 AA03 BB02 DD01 JJ03 4C086 AA01 AA02 EA04 MA01 MA04 NA14 ZA73 ──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme coat ゛ (Reference) A23L 1/06 A23L 1/06 4C086 C07H 15/04 C07H 15/04 A (72) Inventor Yuji Furuya Hiroshima Hiroshima 95 No. 7 Minooki-cho, Fukuyama-shi F-term (reference) in Ikeda Shokuken Co., Ltd. DD01 JJ03 4C086 AA01 AA02 EA04 MA01 MA04 NA14 ZA73
Claims (4)
徴とする腸内菌叢改善剤。An intestinal flora improving agent comprising ethyl-α-glucoside.
として含有することを特徴とする腸内菌叢改善物。2. An intestinal flora improving product comprising ethyl-α-glucoside as an intestinal flora improving agent.
基を有する糖類とエタノールを原料として微生物由来の
酵素α-グルコシダーゼの糖転移活性によって生成され
ることを特徴とする請求項１に記載の腸内菌叢改善剤。3. The intestinal flora improving agent is produced by using a sugar having an α-glucoside group and ethanol as raw materials by the transglycosylation activity of an enzyme α-glucosidase derived from a microorganism. The intestinal flora improving agent according to the above.
ノールを原料として微生物由来の酵素α-グルコシダー
ゼの縮合活性によって生成されることを特徴とする請求
項１に記載の腸内菌叢改善剤。4. The intestinal flora improving agent according to claim 1, wherein the intestinal flora improving agent is produced by a condensation activity of a microorganism-derived enzyme α-glucosidase using glucose and ethanol as raw materials. Agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001156974A JP2002348242A (en) | 2001-05-25 | 2001-05-25 | Agent for improving intestinal bacterial flora and composition for improving intestinal bacterial flora containing agent for improving intestinal bacterial flora |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001156974A JP2002348242A (en) | 2001-05-25 | 2001-05-25 | Agent for improving intestinal bacterial flora and composition for improving intestinal bacterial flora containing agent for improving intestinal bacterial flora |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002348242A true JP2002348242A (en) | 2002-12-04 |
Family
ID=19000907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001156974A Withdrawn JP2002348242A (en) | 2001-05-25 | 2001-05-25 | Agent for improving intestinal bacterial flora and composition for improving intestinal bacterial flora containing agent for improving intestinal bacterial flora |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2002348242A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010115169A (en) * | 2008-11-14 | 2010-05-27 | Kanebo Cosmetics Inc | Method for producing japanese refined sake enzyme-treated product |
| WO2020203655A1 (en) * | 2019-03-29 | 2020-10-08 | サントリーホールディングス株式会社 | Catechin-containing beverage, production method therefor, and method for reducing bitterness of catechin-containing beverage |
| WO2022138651A1 (en) * | 2020-12-22 | 2022-06-30 | サントリーホールディングス株式会社 | Ethyl glucoside-containing composition and method for reducing a pungent taste attributed to ethyl glucoside |
-
2001
- 2001-05-25 JP JP2001156974A patent/JP2002348242A/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010115169A (en) * | 2008-11-14 | 2010-05-27 | Kanebo Cosmetics Inc | Method for producing japanese refined sake enzyme-treated product |
| WO2020203655A1 (en) * | 2019-03-29 | 2020-10-08 | サントリーホールディングス株式会社 | Catechin-containing beverage, production method therefor, and method for reducing bitterness of catechin-containing beverage |
| JPWO2020203655A1 (en) * | 2019-03-29 | 2020-10-08 | ||
| CN113631044A (en) * | 2019-03-29 | 2021-11-09 | 三得利控股株式会社 | Catechin-containing beverage, method for producing same, and method for reducing bitterness of catechin-containing beverage |
| JP7500544B2 (en) | 2019-03-29 | 2024-06-17 | サントリーホールディングス株式会社 | Catechin-containing beverage, its manufacturing method, and method for reducing the bitterness of a catechin-containing beverage |
| WO2022138651A1 (en) * | 2020-12-22 | 2022-06-30 | サントリーホールディングス株式会社 | Ethyl glucoside-containing composition and method for reducing a pungent taste attributed to ethyl glucoside |
| CN116709929A (en) * | 2020-12-22 | 2023-09-05 | 三得利控股株式会社 | Composition containing ethyl glucoside and method for reducing astringency caused by ethyl glucoside |
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| Date | Code | Title | Description |
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| A300 | Withdrawal of application because of no request for examination |
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