JP2002321779A - Diffusing method for microdose medicine and diffusing device for microdose - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a diffusing method for a microdose medicine and a diffusing device for the microdose capable of gradually volatilizing the medicine into the air, which is easy to realize that it is volatilizing and which is simple in structure with which the residue is intelligible. SOLUTION: The medicine to be diffused into the air is filled in a container body 14 of an aerosol vessel 11, the medicine is ejected from the container body 14, the ejected medicine is held in a balloon 12 having the stretchability so as to gradually volatilize the medicine in the balloon through the balloon into the air.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a method and apparatus for microdiffusion of a drug.

[0002]

2. Description of the Related Art Conventionally, as a method of volatilizing volatile chemicals such as insecticides and fragrances in the air, a method of injecting the chemicals into the air in the form of fine mist using an aerosol product is known. There is also known a method in which a medicine is put in a container, and a porous wall surface such as unglazed pottery is impregnated with the medicine in the container to gradually evaporate the medicine from the surface of the wall surface. On the other hand, a type of insecticide that sublimates and evaporates an active ingredient from a solid is also known. This material is suspended in a closet, for example, and the component that kills insects attached to the clothes is gradually sublimated, or the mat-like material is heated by an electric heater to vaporize the component that kills mosquitoes. There is also known a method in which an undiluted solution is dropped on an evaporating dish, and the evaporating dish is heated by an electric heater to evaporate components that kill mosquitoes.

[0003]

In the method of spraying the aerosol product directly into the air, the concentration of the drug in the air is immediately increased, and it is effective immediately, but does not last for a long time. Therefore, in order to maintain the concentration in the air for a long time, it is necessary for the user to inject at regular intervals or to automatically inject at regular intervals by a timer. Therefore, the user becomes complicated and the device becomes complicated. The above-described method of impregnating the porous wall surface with the drug has the advantage of gradually releasing the drug over a long period of time, but there is no real feeling that the drug impregnated on the wall surface evaporates, and the amount of transpiration is difficult to understand. .

In the method of sublimating from a solid, the volume of the solid decreases as the solid sublimates. For this reason, there is an advantage that the user can feel the sublimation and easily understand the remaining amount. However, the components that sublimate are few in number, cannot be used for drugs other than sublimation components, and when unnecessary,
It is difficult to stop sublimation on the way. In addition, the method of evaporating with the heat of the heater is to drop the chemical solution from a glass bottle etc. on a receiving tray and heat the saucer with a heater, and the medicine is automatically replenished from the glass bottle, so there is no need for labor and the chemical solution in the glass bottle The remaining amount is easy to understand. However, equipment such as a heater is required, and it is necessary to constantly supply electricity.

According to the present invention, it is possible to volatilize a drug gradually in the air over a long period of time, and it is easy to realize that the drug is volatilized. It is an object of the present invention to provide a microdiffusion method and a microdiffusion device for a medicine which do not require electricity.

[0006]

According to a first aspect of the present invention, there is provided a method for diffusing a small amount of a drug, wherein the drug to be diffused is filled in a container, and the drug is ejected from the container. , Held in a holding member whose volume change is visible,
It is characterized in that the medicine in the holding member is gradually vaporized into the air. The term “drug” as used herein refers to a substance that is ultimately volatilized irrespective of whether it is a liquid, a gas, or a solid, and includes both the contents filled in the container and the ejected ejected matter. Including.

[0007] A microdiffusion device for a drug of the present invention (Claim 2)
Is a container for filling the drug to be diffused,
A holding member is provided near the injection hole of the container and holds the medicine ejected from the injection hole in a state where the change in volume can be visually observed. In such a micro-diffusion device, the holding member can be a bag through which gas molecules of the volatilized drug can pass (Claim 3). The bag preferably has elasticity (claim 4).

Further, in the micro diffusion device, the holding member may be a cup-shaped receiving member having an opening at an upper portion for receiving the ejected medicine. In this case, it is preferable that a lid that can pass through the upper surface of the ejected medicine and allow gas molecules of the medicine to pass through is accommodated inside the receiver so as to be vertically movable (claim 6).

[0009]

In the method for micro-diffusion of a drug according to the present invention (Claim 1), the drug to be diffused is not injected directly into the air from the container but is once injected into the holding member and held. From this state, it is gradually diffused into the air. Therefore, the amount of the medicine to be diffused or the remaining amount of the medicine injected last time can be known at a glance. Therefore, it is easy to understand the timing of the next ejection from the container and the amount of the ejection. In addition, since the amount of the medicine in the holding member can be visually observed, diffusion into the air can be realized from the decrease. Further, it can be used as a drug other than the sublimation component. Further, no electric equipment such as a heater is required.

[0010] The microdiffusion device of the present invention (claim 2) can easily carry out the above-mentioned microdiffusion method, and can exert the function and effect thereby. That is, since the remaining amount of the medicine in the holding member can be easily visually checked, the diffusion amount and the speed can be realized, and the timing of the next injection can be easily set.

In the case where the holding member is a bag through which gas molecules of the volatilized drug can pass (claim 3), the bag inflates when injected from the container into the bag. Then, as the drug volatilizes through the bag, the bag gradually shrinks, so that the remaining amount can be easily confirmed. Further, when the medicine in the bag is exhausted, the medicine returns to its original state before the injection of the medicine, so that it is clearly understood that the medicine has been used up. When the bag is made of a material having elasticity (claim 4), the shape of the bag from the collapsed state to the expanded state changes more clearly. Therefore, it is easy to check the remaining amount.

When the holding member is a cup-shaped receiving member having an opening at an upper portion for receiving the ejected medicine (claim 5), when the ejected medicine is in the form of a foam, the holding member is directly Since the volume can be seen with the eyes and the volume is expanded by the gas, the change in the volume can be easily recognized. Also,
Regardless of the form, the gel, or the liquid, the remaining amount in the receiving device can be easily checked because it is once stored in the receiving device.

[0013] In the case where the lid which can pass through the upper surface of the ejected medicine and allows the gas molecules of the medicine to pass therethrough is accommodated in the receiving device so as to be vertically movable (claim 6), depending on the position of the lid, The amount of diffusion and the remaining amount can be more easily visually recognized.
Further, when the medicine is in the form of a foam, the upper surface of the ejected matter is flat and uniform, and the volatilization speed can be stabilized. In addition, even when the drug is in a liquid or gel form, the volatilization rate of the drug can be adjusted by the lid, such as by suppressing direct vaporization from the surface of the liquid or gel and gradually releasing gas molecules. it can. Therefore, it is also possible to display the time required for the medicine in the receiver to evaporate.

[0014]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of a micro diffusion apparatus and a micro diffusion apparatus according to the present invention. FIG. 1 is a side view showing an embodiment of a microdiffusion device of the present invention, FIG. 2a is a side view showing another embodiment of a microdiffusion device of the present invention, and FIG. FIG. 3 is a side view of a main part showing still another embodiment of the microdiffusion device of the present invention, FIG. 4a is a side view showing still another embodiment of the microdiffusion device of the present invention, and FIG. It is a principal part side view which shows a use state.

The microdiffusion device 10 shown in FIG. 1 includes an aerosol container 11 and a balloon 12 mounted on the aerosol container 11. The inside of the aerosol container is filled with a medicine (undiluted solution and propellant) 13 which becomes a mist when ejected. The aerosol container 11 includes a container body 14, a valve 15 provided to close an opening at an upper portion of the container body, a nozzle 17 attached to a stem 16 of the valve 15, and an operation lever 18 for operating the valve 15. , A shoulder cover 19. As the container body 14, the valve 15, the nozzle 17, and the shoulder cover 19, conventionally known ones can be adopted.
The nozzle 17 preferably ejects the medicine in a mist. The nozzle hole of the nozzle 17 may be directed upward or forward (leftward in the drawing). The operation lever 18 is for pushing down the stem 16 downward.

As the container body 14, a pressure-resistant container made of metal or synthetic resin and having an opening at the top is used. The nozzle 17 is vertically movable with respect to the shoulder cover 19 via a resin hinge. And a push lever 18 protruding from the base end of the nozzle 17. The valve 15 includes a stem 16 housed in a bottomed cylindrical housing 20 movably up and down, a spring for urging the stem upward, and a mounting cup 21 for attaching the housing 20 to an upper opening of the container body 14.
And an annular valve rubber interposed between the container body 14 and the mounting cup 21. A dip tube 22 is attached below the housing 20.

Drug (contents) to be filled in container body 14
Comprises a stock solution containing a medicinal component and a propellant for spraying the stock solution. Stock solutions include active ingredients such as insecticides, potency enhancers, pest repellents, disinfectants / disinfectants, fresheners, deodorants, and fragrances as water, lower alcohols, polyhydric alcohols, volatile silicone oils, hydrocarbons And those dissolved in a solvent such as ester oil. In addition, as a stock solution,
It is preferable to use a volatile component in order not to remain in the holding member for a long time and to easily volatilize to the outside. A liquefied gas or a compressed gas is used as the propellant. As the liquefied gas, liquefied petroleum gas or dimethyl ether, which is a mixture of propane and butane, and a mixture thereof, and a mixture thereof are used. As the compressed gas, nitrogen, air, carbon dioxide or the like is used.

The balloon 12 has elasticity (elasticity) capable of transmitting gas molecules when the stock solution is vaporized.
For example, a material similar to a conventionally known rubber balloon made of a polymer material having the following, for example, a film or sheet of natural or synthetic rubber or silicone rubber is used. Balloon 12
Is fixed to the nozzle 17.

Next, an embodiment of a method for diffusing a drug into the air using the micro diffusion device 10 constructed as described above will be described. First, when the operating lever 18 is pressed, the valve 1
5 is opened, and the medicine (undiluted solution and propellant) is ejected from the injection hole of the nozzle 17 in the form of mist or mist. This causes the balloon 12 to expand as shown by the solid line. The volume of the balloon 12 in the inflated state increases or decreases according to the volume of the ejected medicine. The undiluted solution floats inside the balloon 12 in the form of a mist, a part of which is vaporized, and the other part is liquefied and adheres to the inner surface of the balloon. In the state where the balloon 12 is inflated in this way,
The user can feel that a large amount of medicine remains in the balloon 12.

The medicine in the balloon 12 permeates the sheet of the balloon 12 with the passage of time and gradually diffuses into the outside air. Note that the vaporized propellant or the propellant in a gaseous state also passes through the sheet and permeates to the outside. Thereby, the internal pressure in the balloon 12 decreases,
Over time, the balloon contracts as shown by the imaginary line. Thereby, the user can witness that the medicine in the balloon 12 is gradually reduced. Then, after the balloon 12 is deflated, the operation lever 21 may be operated again as needed to inflate the balloon 12. For example, in the case of a device that diffuses a fragrance into a room, the olfactory sense that the scent in the room is reduced
The visual confirmation of the deflation of the balloon 12 makes it possible to grasp that the diffusion amount has actually decreased. When a fixed amount valve is used as the valve 15, a predetermined amount of medicine is injected into the balloon 12 by one ejection operation.
As a result, you won't accidentally inject too much drug,
There is no possibility that the balloon 12 will burst. Further, the rupture releases the drug at a stretch, and the concentration of the drug in the air does not suddenly increase.

In the micro-diffusion device 25 shown in FIGS. 2A and 2B, a bag 26 having no elasticity is used in place of the balloon 12. As such a bag 26, a bag formed by bending a sheet made of a synthetic resin such as polyethylene, polypropylene, polyethylene terephthalate, or nylon and air-tightly bonding the periphery thereof can be employed. Other configurations are the same as those in FIG.

When the medicine is ejected into the bag 26, the bag 26 is inflated by the internal pressure as shown in FIG. 2A. As the drug permeates and diffuses through the bag 26, it gradually tapers, as shown in FIG. 2b. Therefore, the user can visually grasp the amount of the medicine in the bag 26, and at the same time, easily visually grasp the amount of the medicine diffused in the air. In addition, it is preferable to provide an auxiliary tool for regulating the outer diameter or the like so that the holding member can contract or deform in a stable shape in the micro diffusion device in FIGS.

The microdiffusion device 30 shown in FIG. 3 includes the aerosol container 11 substantially similar to the above-described case, and a cup-shaped receiving member 32 attached to the stem 16 of the valve of the aerosol container 11. The inside of the container body 14 of the aerosol container is filled with a drug (undiluted solution and propellant) that forms a foam when ejected. The stock solution contains, in addition to the medicinal components, a surfactant for maintaining a foam, water, alcohol, and the like. The spout 34 for ejecting the medicine in a foam shape may be attached to the stem 16 provided at the upper end of the aerosol container 11.

In the micro-diffusion device 30, when the receiving member 32 is pressed downward, the stem 16 is pressed down and the valve is opened. As a result, the undiluted solution and the propellant are ejected from the stem 16 and form the form 35 and accumulate in the receiver 32. Therefore, the user can feel the amount of the ejected medicine by the amount of the foam 35 in the receiving tool 32. Over time, the foam in the foam 35 gradually shrinks and / or ruptures to reduce the volume, and the drug is released into the air. Therefore, the user can intuitively grasp the amount of the drug that has diffused into the air, depending on how the form 35 is reduced. Then, if necessary, the fuel is injected again.

The medicine to be sprayed and stored in the receiving device 32 is not limited to the foam 35, but may be, for example, a gel or a liquid. In the case of a liquid, the amount of the medicine in the receiving device 32 can be visually grasped by the position of the liquid surface. Note that a scale may be provided on the receiving member 32. Further, when the receiving member is formed of a transparent resin, glass, or the like, the remaining amount of the medicine can be more easily grasped. In this embodiment, the receiving member 32 is attached to the stem 16, but the receiving member 32 may be fixed to the container body 14 and an operation lever or a push button for operating the valve may be separately provided.

The micro-diffusion device 40 shown in FIG. 4A has a cup-shaped receiving member 32 substantially similar to the receiving member of FIG. 3, and further comprises a lid 41 which is fitted to the receiving member 32 so as to be vertically movable. I have. The receiving member 32 is formed of a transparent material such as acrylic resin or pressure-resistant glass, and has a receiving member 32 on its side surface.
A scale 43 is provided to indicate the time required for the drug 42 inside to evaporate. The lid 41 may be formed of a porous sheet having air permeability, for example, a thin and light sponge or a fine net. The lid 41 is always in the receiving device 3
2 is located near the bottom (see FIG. 4b). When the user opens the valve by pressing down the receiving device 32 or the like, as shown in FIG. 4A, the user rides on the surface of the medicine 42 ejected into the receiving device 32 and rises as the volume of the medicine 42 increases. Therefore, when the medicine 42 is in the form of a foam,
The surface is flattened. Therefore, the ejected medicine 42
It is easy to grasp the volume.

In the micro-diffusion device 40, as the time elapses, the amount of the drug 42 gradually decreases, and the lid 41 also descends accordingly. Therefore, the remaining amount of the medicine 42 in the receiving tool 32 can be easily grasped. Further, since the upper surface of the medicine 42 is flat by the lid 41, the volatilization speed is also stabilized. Note that, also in the micro-diffusion device 40, the ejected medicine 42 may be in the form of a gel, a liquid, or the like in addition to the foam. When the mist is further sprayed, the lid 41
Is covered, so that it is suppressed from going out into the air from the opening at the upper end of the receiving member 32. Therefore, it can be sprayed in a mist.

Further, the gas permeability of the lid 41 (fineness of the mesh, size of the through-holes, thickness of the lid, etc.) not only in the case of foam but also in the form of liquid or gel. ) Allows the volatilization speed to be adjusted.
As a result, it is preferable to set the time required for volatilizing a predetermined amount, and to provide a scale 43 for the time in the receiver 32, since the required time can be estimated.

In the embodiments shown in FIGS. 3 and 4, a cup-shaped receiving member is used. However, the present invention is not limited to this. The drug can be volatilized for a long time. Further, as the drug to be filled in the microdiffusion device of the present invention, an aerosol composition comprising a stock solution containing an active ingredient and a propellant has been exemplified.
The present invention is not limited to the aerosol composition, and may use a stock solution containing an active ingredient as a drug and eject the drug into the holding member by a pump.

[Brief description of the drawings]

FIG. 1 is a side view showing an embodiment of a micro diffusion device of the present invention.

FIG. 2A is a side view showing another embodiment of the microdiffusion device of the present invention, and FIG. 2B is a side view of a main part showing a use state of the device.

FIG. 3 is a partial cross-sectional side view showing a main part of still another embodiment of the microdiffusion device of the present invention.

FIG. 4A is a partial cross-sectional side view showing still another embodiment of the microdiffusion device of the present invention, and FIG. 4B is a partial cross-sectional main portion side view showing the use state of the device.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 10 Micro diffusion device 11 Aerosol container 12 Balloon 13 Drug 14 Container main body 15 Valve 16 Stem 17 Nozzle 18 Operating lever 19 Shoulder cover 20 Housing 21 Mounting cup 22 Dip tube 25 Micro diffusion device 26 Bag 30 Micro diffusion device 32 Receiver 34 Spout 35 Foam 40 Microdiffusion device 41 Lid 42 Drug 43 Scale

Claims (6)

[Claims] Claims: 1. A medicine to be diffused is filled in a container, and the medicine is ejected from the container.
A method for micro-diffusion of a drug, wherein the drug is held in a holding member whose volume change can be visually observed, and the drug in the holding member is gradually volatilized into air. 2. A container for filling a drug to be diffused, and provided near an injection hole of the container, for holding a drug ejected from the injection hole so that a change in volume thereof can be visually observed. A micro-diffusion device for a medicine, comprising: a holding member. 3. The microdiffusion device according to claim 2, wherein the holding member is a bag through which gas molecules of the volatilized drug can pass. 4. The micro diffusion device according to claim 3, wherein the bag has elasticity. 5. The micro diffusion device according to claim 2, wherein the holding member is a cup-shaped receiving member having an opening at an upper portion for receiving the ejected medicine. 6. The microdiffusion device according to claim 5, wherein a lid that can ride on the upper surface of the ejected medicine and allows gas molecules of the medicine to pass therethrough is accommodated inside the receiver so as to be vertically movable.