JP2002306591A - Medical implement, its manufacturing method and centrifugal liquid pump - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medical implement which is formed without welding and an adhesive and to provide its manufacturing method. SOLUTION: The medical tool 1 is provided with a housing 20 consisting of a first housing forming member 20a and a second housing forming member 20b to be combined with the first member 20a. The housing 20 is provided with a circular abutting line 51 which is formed by combining the first housing forming member 20a with the second member 20b. The medical implement 1 is provided with a metallic circular seal member 52 which is arranged to cover the whole circumference of the abutting line 51 and which is thermally expandable. The metallic circular seal member 52 is arranged at the part of the abutting line 51 in the housing when it is heated and expanded and seals the abutting line 51 of the housing liquid tightly and air tightly by contraction after cooling.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a medical device, a method for manufacturing the same, and a centrifugal liquid pump.

[0002]

2. Description of the Related Art In medical instruments such as centrifugal pumps and pacemakers used for artificial hearts which are to be implanted in the body for a long period of time, mechanical parts, electronic circuits, cables connected to them, etc. are protected from moisture and moisture. It is necessary to prevent gas or liquid inside the device from leaking to the outside. Therefore, it has been practiced to seal the joint surfaces and the like of the devices by using a plastic material having low water absorption or gas permeability. Further, in order to seal the device, a method of molding the implantable medical device together with the housing together with a silicone resin or the like has been adopted.

[0003]

However, a plastic material has a slight gas permeability and a hygroscopic property in a humid environment such as a living body. It is difficult to protect and prevent gas or the like in the housing from leaking to the living body. Furthermore, the plastic material may deteriorate when implanted in the body for a long period of time, and may cause the above-mentioned leakage or the like. For this reason, medical equipment housings intended for long-term use are often formed of metal. However, when the housing is formed of metal, it is necessary to perform welding when assembling the housing. The heating during welding may cause distortion in the housing. Although assembly with an adhesive is possible, there is a problem of elution and deterioration of the adhesive.

Accordingly, the present invention solves the above-mentioned problems, and in a medical instrument for forming a housing by assembling two metal housing assembling members, the assembling portion can be reliably formed without using welding or an adhesive. And a method of manufacturing the medical device and a centrifugal liquid pump.

[0005]

The above objects can be achieved by (1) a first housing forming member made of metal and a second metal forming member combined with the first housing forming member.
A medical device having a housing comprising: a housing forming member; wherein the housing includes an annular butting line formed by combining the first housing forming member with the second housing forming member; The medical device includes a thermally expandable metal annular seal member provided so as to cover the entire circumference of the butting line, and
The metallic annular seal member is a medical device that is disposed at the abutting line portion of the housing during heat expansion and contracts after cooling to seal the abutting line portion of the housing in a liquid-tight and air-tight manner.

(2) In the above (1), the first housing forming member includes a first housing forming member side annular sealing member housing groove capable of housing an upper portion of the annular sealing member, and the second housing forming member has an annular sealing member housing groove. The housing forming member has a second housing forming member side annular sealing member housing groove capable of housing a lower portion of the annular sealing member, and combines the first housing forming member and the second housing forming member. Thus, it is preferable that the first housing forming member side annular seal member housing groove and the second housing forming member side annular seal member housing groove form an annular seal member housing portion.

[0007] The above object is achieved by (3)
A method for manufacturing a medical device having a housing comprising a first housing forming member made of metal and a second housing forming member made of metal combined with the first housing forming member, wherein the first housing forming member is provided. Member and second
And expanded by heating so as to cover the position of the annular butting line formed when the first housing forming member and the second housing forming member are combined. After performing the step of arranging the metal annular seal member, the step of assembling the housing forming member and the step of arranging the seal member, the metal annular seal member is cooled so that the seal member is connected to the butting line of the housing. This is a method for manufacturing a medical device including a sealing step of making a liquid-tight and air-tight contact with a partial outer surface.

[0008] The above object is achieved by (4)
A method for manufacturing a medical device having a housing comprising a first housing forming member made of metal and a second housing forming member made of metal combined with the first housing forming member, wherein the first housing forming member is provided. The member includes a first housing forming member side annular seal member housing groove capable of housing an upper portion of the metal annular seal member, and the second housing forming member houses a lower portion of the metal annular seal member. A second housing forming member-side annular seal member housing groove, and a first housing forming member-side annular seal member housing groove formed by combining the first housing forming member and the second housing forming member. An annular seal member storage portion is formed by the second housing formation member side annular seal member storage groove; The method of manufacturing a medical device may further include a metal ring having a non-heating inner diameter smaller than the inner diameter of the first housing forming member side annular sealing member housing groove and the second housing forming member side annular sealing member housing groove. Preparing a seal member, heating the metal annular seal member, and increasing the inner diameter of the seal member to be larger than the inner diameter of the storage groove; and heating the metal annular seal. A seal member disposing step of disposing a member in the first housing forming member side annular seal member receiving groove or the second housing forming member side annular seal member receiving groove; and a seal member is disposed by the seal member disposing step. A housing forming member set for combining the other housing forming member with the first housing forming member or the second housing forming member A step, a method for producing a medical device is intended to perform a sealing member cooling step to maintain the state of being combined with the housing union step of cooling the seal member.

(5) In the above (3) or (4), in the method for manufacturing a medical device, the first housing forming member and the second housing forming member are cooled before the seal member arranging step. It is preferable to include a housing forming member cooling step of shrinking the housing.

[0010] The above object can be achieved by (6)
A housing formed by combining a first metal housing forming member having a blood inflow port and a second metal housing forming member having a blood outflow port; A centrifugal liquid pump having an impeller for sending blood by centrifugal force at the time, wherein the housing has an annular butting formed by combining the first housing forming member with the second housing forming member. Equipped with lines,
The centrifugal liquid pump includes a thermally expandable metallic annular seal member provided so as to cover the entire circumference of the abutment line, and the metallic annular seal member is configured to mate the housing with the abutment when heated and expanded. A centrifugal liquid pump which is arranged in a line portion and seals the abutting line portion of the housing in a liquid-tight and air-tight manner by contraction after cooling.

(7) In the above (6), the first housing forming member includes a first housing forming member side annular seal member housing groove capable of housing an upper portion of the annular seal member, and the second housing forming member has a second housing seal groove. The housing forming member has a second housing forming member side annular sealing member housing groove capable of housing a lower portion of the annular sealing member, and combines the first housing forming member and the second housing forming member. Thus, it is preferable that the first housing forming member side annular seal member housing groove and the second housing forming member side annular seal member housing groove form an annular seal member housing portion.

(8) In the above (6) or (7), the impeller includes a magnetic substance therein, and the centrifugal liquid pump includes a rotor including a magnet for attracting the magnetic substance of the impeller; It is preferable to include an impeller rotation torque generating unit including a motor for rotating the rotor, and an impeller position control unit including an electromagnet for attracting the impeller.

(9) In any one of the above (6) to (8), the metal annular seal member includes a first housing member rib extending inward from an upper side of an inner surface of the seal member and an inner surface of the seal member. A second housing member rib extending inward from the lower side, and wherein the first housing member includes a first housing side recess for accommodating the first housing member rib of the seal member. The second housing member includes a second housing-side concave portion for accommodating a second housing member rib of the seal member, and the metal annular seal member is configured to have the butting line of the housing when heated and expanded. A liquid-tight and air-tight seal of the abutting line portion of the housing by shrinkage after cooling,
Preferably, the housing member rib is housed in the first housing side recess, and the second housing member rib of the seal member is housed in the second housing side recess.

[0014]

Embodiments of the present invention will be described below in detail with reference to the accompanying drawings. In particular, an embodiment in which the medical device of the present invention is applied to a centrifugal liquid pump will be described. The medical device 1 of the present invention is a medical device 1 having a housing 20 including a first housing forming member 20a and a second housing forming member 20b combined with the first housing forming member 20a. A first housing forming member 20a and a second housing forming member 20b are combined to form an annular butting line 51, and the medical device 1 is provided so as to cover the entire circumference of the butting line 51. A metal annular seal member 52 which is thermally expandable is provided, and the metal annular seal member 52 is disposed at the abutting line 51 of the housing at the time of heating and expansion, and shrinks after cooling.
One part is liquid-tightly and air-tightly sealed.

FIG. 1 is a front view of an embodiment in which the medical device of the present invention is applied to a centrifugal liquid pump, particularly a centrifugal blood pump. FIG. 2 is a plan view of the centrifugal liquid pump shown in FIG. FIG. 3 is a bottom view of a first housing forming member used in the centrifugal liquid pump of FIG. FIG. 4 is a plan view of the centrifugal liquid pump when the first housing forming member is removed from the centrifugal liquid pump. FIG.
FIG. 2 is a sectional view taken along line AA of the centrifugal liquid pump shown in FIG. 1.
FIG. 6 is a longitudinal sectional view of the centrifugal liquid pump of FIG. In addition, only the impeller in FIG. 6 is shown in a cross section taken along line BB in FIG.

The centrifugal liquid pump (specifically, centrifugal blood pump) 1 of the present invention has a first housing forming member 20a having a blood inflow port 22 and a second housing having a blood outflow port 23. The centrifugal liquid pump 1 includes a housing 20 formed by combining the forming member 20b and an impeller 21 that rotates inside the housing 20 and sends blood by centrifugal force during rotation. An annular butting line 51 formed by combining the first housing forming member 20a with the second housing forming member 20b,
The centrifugal liquid pump 1 includes a thermally expandable metallic annular seal member 52 provided so as to cover the entire circumference of the butting line 51.
In addition, the metal annular sealing member 52 is disposed at the abutting line 51 of the housing 20 at the time of thermal expansion and contracts after cooling to seal the annular abutting line 51 of the housing 20 in a liquid-tight and air-tight manner.

The centrifugal liquid pump 1 of this embodiment is used in a centrifugal liquid pump device. As shown in FIGS. 1 and 6, a housing 20 having a liquid inflow port 22 and a liquid outflow port 23 is provided. , A centrifugal liquid pump unit 2 having an impeller 21 that rotates inside the housing 20 and sends liquid by centrifugal force during rotation, and a magnetic member 25 of the centrifugal liquid pump unit 2. Rotor 31 with magnet 33 for attracting body 25
And an impeller rotation torque generating unit 3 including a motor 34 for rotating the rotor 31 and an impeller position control unit 4 including an electromagnet 41 for attracting the impeller 21. The rotation speed of the motor 34, the position of the impeller 21 and the like are controlled by a control device (not shown).

As shown in FIGS. 1 and 6, the housing 20 is formed in a disk shape having a space therein.
And a second housing forming member 21. A liquid inflow port 22 is provided at an upper portion of the first housing forming member 20a so as to protrude vertically upward from substantially the center. As shown in FIGS. 2 and 4, a blood outflow port 23 is provided on the side surface of the second housing forming member 20b so as to protrude in a tangential direction of the side surface. Further, in the housing 20 formed by combining the first housing forming member 20a and the second housing forming member 20b, a blood chamber 24 that connects the blood inflow port 22 and the blood outflow port 23 is formed. I have. The impeller 21 is housed in the blood chamber 24. In addition, the butting line 51 is formed by combining the first housing forming member 20a and the second housing forming member 20b.

The first housing forming member 20a is
In the part combined with the housing forming member 20b,
As shown in FIGS. 3 and 6, a butting portion 81 a which is a butting line forming member, a fixed member attaching portion 82 a formed to surround the butting portion 81 a, and a portion between the butting portion 81 a and the fixed member attaching portion 82 a. A seal member accommodating groove 83a is formed and accommodates an upper portion of the seal member 52 described later. Similarly, the portion of the second housing forming member 20b combined with the first housing forming member 20a is formed so as to surround the butting portion 81b and the butting portion 81b as shown in FIGS. A fixing member mounting portion 82b, an abutting portion 81b, a fixing member mounting portion 82b, and a seal member accommodating groove 83b formed between the abutting portion 81b and the fixing member mounting portion 82b.

Then, by combining the two,
Butt portions 81a, 81b and fixing member mounting portions 82a, 82b
A seal member housing 83 is formed therebetween. In addition, the seal member housing portion 83 includes a seal member housing groove 83a and a seal member housing groove 83b. Also, the abutting part 8
The annular butting line 51 is formed by the outside of the contact surface of the butting portion 1a and the butting portion 81b.
Are formed. Then, the annular seal member storage section 83
The annular sealing member 52 is housed in the
The inner surface of the seal member 52 is in close contact with the outer surface of the butting portion 81a of the first housing forming member and the outer surface of the butting portion 81b of the second housing forming member so as to cover the first member. As a result, the entire annular butting line 51 is sealed liquid-tight and air-tight.

As shown in FIGS. 3, 6, and 9, the abutting portion 81a of the first housing forming member 20a is annularly shaped downward (in other words, short) along the opening of the first housing forming member 20a. It is formed so as to project in a cylindrical shape. Contact surface 91a of butting portion 81a with butting portion 81b
Is a flat surface. The contact surface 91 is formed perpendicular to the center axis of the housing 20. Second
The butting portion 81b of the housing forming member 20b of FIG.
As shown in FIG. 6, the second housing forming member 20b is formed so as to protrude upward along the opening of the second housing forming member 20b in an annular shape (in other words, a short cylindrical shape). The butting portion 81b and the butting portion 81a are formed so that at least the outer diameter is equal, and it is preferable that the inner diameter is also equal. Also,
The contact surface 91b of the butting portion 81b with the butting portion 81a is formed flat. The contact surface 91b is formed perpendicular to the center axis of the housing 20.

As shown in FIGS. 3, 6, and 9, the fixing member mounting portion 82a of the first housing forming member 20a is formed in an annular shape (in other words, a short cylindrical shape) and surrounds the abutting portion 82a. And is formed in an annular shape (in other words, a short cylindrical shape). The contact surface 92a of the fixing member mounting portion 82a with the fixing member mounting portion 82b is a flat surface. Also, the contact surface 92a of the fixing member mounting portion 82a
Are formed perpendicular to the central axis of the housing 20. Also, the second housing forming member 20b is attached to the fixing member mounting portion 92a of the first housing forming member 20a.
A through-hole 54 for attaching a fixing member 53 for securely fixing the first housing forming member 20a to the first housing forming member 20a is formed. Preferably, a plurality of through holes 54 are provided. In particular, it is preferable that a plurality of through holes 54 are provided at an equal angle with respect to the center axis of the housing.

As shown in FIGS. 4, 6, and 9, the fixed member mounting portion 82b of the second housing 20b has a butted portion 81b formed in an annular shape (in other words, a short cylindrical shape).
Is similarly formed in an annular shape (in other words, a short cylindrical shape) so as to surround. Further, the contact surface 92b of the fixing member mounting portion 82b with the fixing member mounting portion 82a is a contact surface 92b.
It is formed on a flat surface like a. Also, the contact surface 92
b is formed substantially perpendicular to the central axis of the housing 20. The fixing member mounting portion 92a of the second housing forming member 20b includes a fixing member mounting hole 55 formed at a position corresponding to the fixing member mounting portion 81b of the first housing forming member 20a. On the inner surface of the mounting member mounting hole 55, a screw groove for screwing with a screw thread formed on the outer surface of the mounting member 53 is formed. Preferably, a plurality of fixing member mounting holes 55 are provided. In particular, it is preferable that a plurality of fixing member mounting holes 55 are provided at an equal angle with respect to the center axis of the housing. In this embodiment, the through hole 54 for the fixing member is provided on the first housing forming member side, and the mounting hole 55 for fixing with the fixing member is provided on the second housing forming member side. It is not limited to this. A through hole for a fixing member is provided on the second housing forming member side, a mounting hole for fixing with the fixing member is provided on the first housing forming member side, and the fixing member is provided from the second housing forming member side. It may be inserted and fixed.

As shown in FIGS. 3, 6, and 9, the seal member accommodating groove 83a of the first housing 20a is formed between an annular abutting portion 81a and an annular fixing member mounting portion 82a. It is a recess. Similarly, as shown in FIGS. 4, 6, and 9, the seal member accommodating groove 83b of the second housing 20b is formed between the annular abutting portion 81b and the annular fixing member mounting portion 82b. It is a recess. Then, the first housing forming member 20a and the second housing forming member 20b are joined to each other by an abutting portion 81a and an abutting portion 81b.
The blood chambers 24 are formed inside the housing by butting them so as to be in close contact with each other. Note that the shape of the contact surface of the abutting portion is not limited to the flat surface as described above, and the contact surface of the first housing and the contact surface of the second housing forming member are formed in such a shape that they can make surface contact with each other. You may.
The outer diameter of the abutting portion 81a and the abutting portion 81b differs depending on the size of the liquid pump and is not uniform.
About 0 mm is common. Further, the fixing member mounting portion 82
When the first housing forming member 20a and the second housing forming member 20b are combined, the fixing member a and the fixing member mounting portion 82b preferably contact each other without any gap. The shape of the contact surface of the fixing member mounting portion is not limited to the flat surface as described above, and the contact surface on the first housing side and the contact surface on the second housing forming member can be substantially in surface contact with each other. It may be formed in a shape.

The seal member accommodating groove 83a and the seal member accommodating groove 83b are formed between the first housing forming member 20a and the second housing forming member 83a.
When the housing forming member 20b is combined, a space 83 for accommodating the seal member 52 is formed inside. In the embodiment, the seal member accommodating groove 83a and the seal member accommodating groove 8 are provided.
3b is made at substantially the same depth. The depth of each of the seal member accommodating grooves 83a and 83b is shorter than the axial thickness of the seal member 52 at room temperature, and the axial direction of the space 83 formed by the seal member accommodating groove 83a and the seal member accommodating groove 83b. Is made longer than the axial thickness of the seal member 52 expanded by heating. By manufacturing in this manner, in the sealing step and at the time of implantation into the body, the inner peripheral surface of the seal member 52 surely contacts the outer surface including the butting line 51 formed by the abutting portion 81a and the butting portion 81b. Contact.

Metal is used as a constituent material of the first housing forming member 20a and the second housing forming member 20b. Particularly, a metal having biocompatibility is preferable. As the biocompatible metal, for example, titanium, a titanium alloy, stainless steel, or the like is preferable. The metallic annular sealing member 52 is formed of a metal that can be thermally expanded. In particular,
It is preferably made of a biocompatible metal. As the biocompatible metal, titanium, a titanium alloy, stainless steel, gold, a gold alloy and the like are preferable. Further, it is preferable that the seal member 52 is made of the same material as the housing 20 in order to enhance the sealing performance in a sealed state.

The surface of the seal member 52 may be coated with a highly malleable metal. By coating the metal in this manner, the airtightness with the housing can be improved. As the metal, a noble metal having excellent malleability and ductility is preferable. Specifically, the sealing member 52
Is made of a titanium alloy, it is preferable to use electroless plating of palladium or plated with platinum or the like, and when the sealing member 52 is made of stainless steel,
Those plated with gold, platinum or the like are preferred. Thereby, the adhesion between the annular seal member 52 and the contact portion of the housing is enhanced, and the liquid tightness is improved.

The inner diameter of the metallic annular seal member 52 is adjusted so that the inner peripheral surface of the seal member 52 securely seals the outer surface including the butt line 51 formed by the butt portion 81a and the butt portion 81b. It is made slightly smaller than the outer diameter of the parts 81a, 81b. Specifically, when the seal member 52 is made of a titanium alloy, the inner diameter of the seal member 52 in the normal temperature state is equal to the abutting portion (in other words, the abutting portion 8).
0.02 to 0.08 m from the outer diameter of 1a and the abutting portion 81b)
It is preferable that it is made smaller by m (it depends on the outer diameter of the butted portion, the allowable tensile strength, the heating conditions, etc., but this is a practical value). The difference between the inner diameter of the seal member 52 and the outer diameter of the abutting portion (the abutting portion 81a and the abutting portion 81b) (shrink fit = increase of the inner diameter of the sealing member + decrease of the outer diameter of the abutting portion) is as described above. If it is within the range, the sealing member 52
Sufficient contact stress is generated between the sealing member 52 and the butting portion.
Are securely fixed to the outer periphery of the abutting portion, and assembly is easy.
Specifically, the inner diameter of the seal member 52 is preferably 40 to 60 mm. The contact stress when the seal member 52 is shrink-fitted to the butting portion of the housing is 2.5
It is preferably 10 to 10 kg / mm ² . If the contact stress is in such a range, at the time of implantation in the body,
The sealing member 52 securely seals the butting line portion of the butting portion. In the present invention, since the seal member is not used for sealing the rotating body, the contact stress between the seal member 52 and the abutting portion may be relatively small.

In this embodiment, at least the inner peripheral surface of the seal member 52 is annularly flat so as to securely adhere to the outer peripheral surfaces of the butting portions 81a and 81b of the housing forming members 20a and 20b in a liquid-tight state. Surface. Further, it is preferable that the thickness of the seal member 52 in the axial direction is manufactured so as to have the above-described relationship with the depth of the seal member housing groove. Specifically, the thickness of the seal member 52 in the axial direction is preferably 1 to 6 mm. Further, specifically, the thickness of the seal member 52 in the axial direction is determined by the depth (length in the axial direction) of the seal member housing portion 83 formed when the first housing forming member and the second housing forming member are combined. Therefore, it is preferable that the width is smaller by 1 to 4 mm. The radial width of the seal member 52, in other words, half of the difference between the outer diameter and the inner diameter, is manufactured such that the radial thickness of the heated and expanded seal member 52 is shorter than the radial length of the seal member receiving groove. Specifically, the thickness is preferably 1 to 6 mm (depending on the thickness). Further, the width of the seal member 52 in the radial direction is more specifically 1 to 1 than the width of the seal member housing portion 83 formed when the first housing forming member and the second housing forming member are combined.
It is preferably smaller by 2 mm.

The form of the joint between the first housing forming member and the second housing forming member is not limited to the above. For example, FIG. 10 and FIG.
1 may be used. Centrifugal liquid pump (specifically, centrifugal blood pump) 1 of this embodiment
0, the butting portion 81 of the first housing forming member 20a
a further includes an annular rib 81c protruding downward. A recess 81d for accommodating the annular rib 81c is formed in the abutting portion 81b of the second housing forming member 20b. In the centrifugal liquid pump 10 of this embodiment, by combining the first housing forming member 20a and the second housing forming member 20b,
While the butting part 81a and the butting part 81b are in surface contact,
The annular rib 81c of the first housing forming member 20a is housed in the concave portion 81d of the second housing forming member 20b, and the combination of both can be easily performed. In this embodiment, the abutting portion 81a and the abutting portion 81b are also used.
Is preferably brought into surface contact, and therefore, as shown in FIG. 11, the lower surface of the annular rib 81c is formed so as not to contact the concave portion 81d. Further, the annular rib may be provided on the second housing forming member, and the concave portion may be provided on the first housing forming member. The difference between the centrifugal liquid pump 10 of this embodiment and the above-described centrifugal liquid pump 1 is as follows.
Only the shape of the butting portion 81a and the butting portion 81b is the same as that of the centrifugal liquid pump 10 described above in other respects.

Further, in this embodiment, a first screw portion (specifically, a screw thread) is provided on the outer surface of the annular rib 81c of the first housing forming member 20a, and the second housing forming member 20b is provided with a first screw portion. A second screwing portion (specifically, a screw groove) for screwing with the first screwing portion is provided on the inner surface of the concave portion 81d, and the combination of the second housing forming member with one housing forming member is as follows. Alternatively, it may be formed by screwing of screwing portions provided on both. Further, as described above, the annular rib may be provided on the second housing forming member, and the concave portion may be provided on the first housing forming member. In this case, the first
A first screwing portion (specifically, a screw groove) is provided on the inner surface of the concave portion of the housing forming member 20a, and the first screwing portion is formed on the outer surface of the annular rib of the second housing forming member 20b. A second screw portion (specifically, a screw thread) to be screwed is provided.

The form of the joint between the first housing forming member and the second housing forming member may be as shown in FIGS. 12 and 13. In the centrifugal liquid pump (specifically, the centrifugal blood pump) 30 of this embodiment, the metal annular seal member 52 is provided with a first housing member rib 52a extending inward from the upper side of the inner surface of the seal member 52. And a second housing member rib 52 b extending inward from a lower side of the inner surface of the seal member 52. The ribs 52a and 52b may be annular ribs or interspersed ribs. Then, the first housing member 20a
Is a first housing member rib 52 of the seal member 52.
a is provided on the first housing side recessed portion 85a for accommodating a. The second housing forming member 20b includes the sealing member 5
A second housing-side concave portion 85b for accommodating the second second housing member rib 52b is provided. The first housing-side recess 85a and the second housing-side recess 85b
It is preferably an annular recess. The metallic annular seal member 52 is disposed at the abutting line 51 of the housing 20 during heating and expansion, and contracts after cooling.
And a first housing member rib 52 of the seal member 52.
a is housed in the first housing side recess 85a, and the second housing member rib 52b of the seal member 52 is housed in the second housing side recess 85b.

Also in this embodiment, the abutting portion 81a
Preferably, the inner surfaces of the ribs 52a and 52b are formed so as not to contact the recesses 85a and 85b, as shown in FIG. The distance between the lower surface (inner surface) of the rib 52a and the upper surface (inner surface) of the rib 52b is larger than the distance between the lower surface of the concave portion 85a of the housing 20 and the upper surface of the concave portion 85b.

In a blood chamber 24 formed in the housing 20 of the liquid pump 1, a disk-shaped impeller 21 having a through hole in the center is accommodated. Impeller 21
Is a donut plate-like member (lower shroud) 27 forming a lower surface, a donut plate-like member (upper shroud) 28 forming an upper surface and having an open center, and a plurality (for example, seven) formed between them. It has a vane 18. And
A plurality (for example, seven) of blood passages 26 are formed between the lower shroud and the upper shroud and are partitioned by adjacent vanes 18.

A plurality of magnetic bodies 25 (permanent magnets, driven magnets) are embedded in the impeller 21.
The embedded magnetic body 25 (permanent magnet) attracts the impeller 21 to a side opposite to the blood inflow port 22 by a permanent magnet 33 provided on a rotor 31 of the impeller rotating torque generating unit 3 described later, and also applies the rotating torque to the impeller. It is provided to enable transmission from the rotation torque generating unit. Further, the impeller 21 includes the upper shroud itself or a magnetic member 28 provided in the upper shroud. In this embodiment, the entire upper shroud is formed by the magnetic member 28. The magnetic member 28 is provided for attracting the impeller 21 to the blood inflow port 22 side by an electromagnet 41 of an impeller position control unit described later.

The impeller rotation torque generating section 3 includes a rotor 31 housed in the housing 20 and a motor 34 for rotating the rotor 31 (the internal structure is omitted). The rotor 31 includes a rotating plate 32 and a plurality of permanent magnets 33 provided on a first surface (a surface on the liquid pump side) of the rotating plate 32.
Consists of The impeller position controller 4 includes a plurality of fixed electromagnets 41 for attracting the magnetic member 28 of the impeller.
And a position sensor 42 for detecting the position of the magnetic member 28 of the impeller. The position sensor 42 detects a gap between the electromagnet 41 and the magnetic member 28, and the detection output is fed back to a control unit that controls a current or a voltage applied to a coil of the electromagnet 41. With the above-described configuration, the impeller position control unit 4 and the impeller rotation torque generating unit 3 form a non-contact magnetic bearing, and the impeller 21 is pulled in the opposite directions, so that It stabilizes at an appropriate position that does not come into contact with the inner surface of the housing 20, and rotates inside the housing 20 in a non-contact state.

Next, a method of manufacturing a medical device according to the present invention will be described using the above-described centrifugal liquid pump. FIG. 7 shows FIG.
FIG. 8 is a front view of a metal annular seal member used for manufacturing the centrifugal liquid pump of FIG. 1, FIG. 8 is a plan view of a seal member used for manufacturing the centrifugal liquid pump of FIG. 1, and FIG. It is explanatory drawing for demonstrating the manufacturing method of a centrifugal liquid pump. The method for manufacturing a medical device according to the present invention provides a medical device having a housing 20 including a first housing forming member 20a made of metal and a second housing forming member 20b made of metal combined with the first housing forming member 20a. It is a manufacturing method of. And the manufacturing method of the medical device of the present invention combines the step of combining the first housing forming member 20a and the second housing forming member 20b with the step of combining the first housing forming member 20a and the second housing forming member 20b. Arranging a metal annular seal member 52 expanded by heating so as to cover a position to be an annular butting line 51 formed at the time of forming, a housing forming member combining step, and a sealing member arranging step. After that, a sealing step is provided to cool the metallic annular sealing member so that the sealing member 52 is in liquid-tight and air-tight contact with the outer surface of the butt line 51 of the housing 20.

Further, the method for manufacturing a medical device according to the present invention is directed to a housing comprising a first housing forming member 20a made of metal and a second housing forming member 20b made of metal combined with the first housing forming member 20a. 20. A method of manufacturing a medical device, comprising: a first housing forming member 20a having a first housing forming member side annular seal member storage groove 83a capable of storing an upper portion of a metal annular seal member 52; Second housing forming member 20
b is a second housing forming member side annular seal member storage groove 8 capable of storing a lower portion of the metallic annular seal member 52.
3b and the first housing forming member 20
a and the second housing forming member 20b, an annular sealing member housing 83 is formed by the first housing forming member side annular sealing member housing groove 83a and the second housing forming member side annular sealing member housing groove 83b. Things. And the manufacturing method of the medical device of the present invention has a non-heating inner diameter smaller than the inner diameter of the first housing forming member side annular seal member accommodating groove 83a and the second housing forming member side annular seal member accommodating groove 83b. A metal annular seal member 52 is prepared, the metal annular seal member 53 is heated, and the inner diameter of the seal member 52 is made larger than the inner diameter of the storage groove 83. Annular sealing member 52
To the first housing forming member side annular seal member storage groove 8.
3a or the first sealing member disposed in the second housing forming member side annular sealing member housing groove 83b, and the first sealing member 52 disposed in the sealing member disposing step.
The housing forming member combining step of combining the other housing forming member with the housing forming member 20a or the second housing forming member 20b, and the sealing member 52 is maintained while being combined by the housing combining step.
And a sealing member cooling step of bringing the seal member 52 into liquid-tight and air-tight contact with the outer surface of the butting line 51 of the first housing forming member and the second housing forming member. First, the preparation of the metal annular seal member 52 and the heating step thereof will be described.

The metal annular sealing member 52 is shown in FIGS.
It is a metal ring-shaped member as shown in FIG. When the metal seal member 52 is shrink-fitted on the outer periphery of the abutting portion 81,
This is for sealing the butting line 51 of the butting portion 81 on the inner peripheral surface in a liquid-tight and air-tight manner. Also, in this embodiment,
The seal member 52 is made of a solid metal, but is not limited to this, and may be a hollow metal ring.
Further, in the embodiment, the cross-sectional shape of the seal member 52 is made rectangular, but is not limited to this, and may be any shape as long as it is in close contact with the outer peripheral surface of the abutting portion.
In addition, the seal member 52 includes the housing forming member 20a,
In this embodiment, at least the inner peripheral surface is an annular flat surface in order to securely adhere to the outer peripheral surfaces of the abutting portions 81a and 81b in a liquid-tight and air-tight state.

The first housing forming member 20a and the second housing forming member 20b used in the medical device of the present invention are formed of metal. Particularly, a metal having biocompatibility is preferable. As the biocompatible metal, for example, titanium, a titanium alloy, stainless steel, or the like is preferable. The metallic annular sealing member 52 is formed of a metal that can be thermally expanded. In particular, it is preferably made of a biocompatible metal. As the biocompatible metal, titanium, a titanium alloy, stainless steel, gold, a gold alloy and the like are preferable. In addition, the seal member 52 is preferably made of the same material as the housing 20 in order to enhance the sealing performance in a sealed state. Also, the sealing member 52
May be coated with a highly malleable metal. By coating the metal in this manner, the airtightness with the housing can be improved. As the metal, a noble metal having excellent malleability and ductility is preferable. Specifically, when the sealing member 52 is made of a titanium alloy, it is preferable that the sealing member 52 be plated with electroless plating of platinum or with platinum, and when the sealing member 52 is made of stainless steel, it is plated with gold, platinum, or the like. Is preferred. Thereby, the adhesion between the annular seal member 52 and the contact portion of the housing is enhanced, and the liquid tightness is improved.

The inner diameter of the seal member 52 is
Of the first housing forming member 20a
Abutment portion 81b between first housing forming member 20b and first housing forming member 20b
It is made slightly smaller than the outer diameter of the abutting portion so as to reliably seal the outer surface including the abutting line 51 formed by the abutting. Specifically, when the seal member 52 is made of a titanium alloy, the inner diameter of the seal member 52 in the normal temperature state is 0.02 to 0.02 from the outer diameter of the abutting portion (in other words, the abutting portion 81a and the abutting portion 81b). It is preferable to make it smaller by 0.08 mm (it depends on the outer diameter of the abutting portion, the allowable tensile strength and the heating conditions, but this is a practical value). Difference between the inner diameter of the seal member 52 and the outer diameter of the abutting portion (the abutting portion 81a and the abutting portion 81b) (shrink fit = increase of the inner diameter of the sealing member + decrease of the outer diameter of the abutting portion).
Is within the above range, a sufficient contact stress is generated between the seal member 52 and the abutting portion, and the seal member 52 is securely fixed to the outer periphery of the abutting portion, and assembly is easy. Specifically, the inner diameter of the seal member 52 is preferably 40 to 60 mm. The contact stress when the seal member 52 is shrink-fitted to the abutting portion of the housing is 2.5 to 10
It is preferably kg / mm ² . If the contact stress is within such a range, the seal member 52 reliably seals the joint line portion of the abutting portion when implanted in the body. In the present invention, since the seal member 52 is not used for sealing the rotating body, the contact stress between the seal member 52 and the abutting portion may be relatively small.

The thickness of the sealing member 52 in the axial direction is
It is manufactured in such a size as to have the above-described relationship with the depth of the seal member accommodation groove. Specifically, the thickness of the seal member 52 in the axial direction is preferably 1 to 6 mm. Further, specifically, the thickness of the seal member 52 in the axial direction is smaller by 1 to 4 mm than the depth of the seal member storage portion 83 formed when the first housing forming member and the second housing forming member are combined. Is preferred. The radial width of the seal member 52, in other words, half of the difference between the outer diameter and the inner diameter, is set such that the radial thickness of the heated and expanded seal member 52 is shorter than the radial length of the seal member receiving groove. It is preferable that the thickness be specifically 1 to 6 mm (depending on the thickness). Further, the width of the seal member 52 in the radial direction is more specifically 1 to 2 than the width of the seal member storage portion 83 formed when the first housing forming member and the second housing forming member are combined.
mm is preferred.

The seal member 52 manufactured as described above is heated using an autoclave until the inner diameter of the seal member 52 becomes slightly larger than the outer diameter of the abutting portion 81. The required temperature difference between the seal member 52 and the abutting portion 81 preferably conforms to the following equation (1). ΔT = δ / (αd) (1) (δ is shrink fit, α is coefficient of linear expansion of seal member, d is diameter of contact circle between seal member and abutting portion)

When the constituent materials of the seal member and the housing are the same and the thicknesses of the seal member and the abutting portion in the radial direction are the same, the necessary temperature difference between the seal member and the housing is expressed by the following equation (2). Preferably, they are compatible. ΔT = 2σ / (αE) (2) (σ is the tensile strength of the seal member and the housing, α is the coefficient of linear expansion of the seal member, and E is the longitudinal modulus of the constituent material of the seal member and the housing)

The equation (2) is obtained from the equations (1), (3), (4), (5), (6) and (7) as follows. _{σ p = (δ / d)} (1 / h p) [1 / (h p E p) + 1 / (h c E c)] ·· (3) σ c = (δ / d) (1 / h c _{) [1 / (h p E} p) + 1 / (h c E c)] ·· (4) (σ p is the tensile strength of the sealing member, sigma _c is butting portion of the tensile strength, _{h p} is the sealing member longitudinal elastic coefficient of the radial thickness, the radial thickness of h _c is butting portion, E _p is the sealing member, E
_c is the longitudinal elastic modulus of the abutment)

If the thickness of the sealing member and the abutting portion in the radial direction are the same and the constituent materials of the sealing member and the housing are the same, the following expressions (5), (6) and (7) are obtained. Holds. _{h p = h c ··· (5} ) E p = E c = E ··· (6) σ p = σ c = σ ··· (7)

Therefore, Equations (3) and (4) are replaced by Equations (5) and (5).
By substituting the equations (6) and (7), δ = 2d
Since it becomes σ / E, when this is substituted into Expression (1), Expression (2) is derived. In this case, the required temperature difference is
It is determined by the modulus of longitudinal elasticity, which is a constant of the constituent materials of the seal member and the housing, the coefficient of linear expansion of the seal member, and the contact stress between the seal member and the housing. The heating temperature is the same as that of the medical instrument, in this embodiment, the centrifugal liquid pump 1.
In order to reduce the influence on the internal components, it is preferable to perform the process at a temperature as low as possible (titanium has a small thermal conductivity, so the effect on the internal components is relatively small). Specifically, when the constituent materials of the sealing member and the housing are both titanium alloy, the temperature is preferably 200 ° C. or lower, particularly preferably 150 ° C. or lower.

Next, a process of disposing the heated seal member 52 and assembling the housing is performed. First, as shown in FIG. 9, the second housing forming member 20b is fixed with the opening facing upward, and the impeller 21 is placed in the second housing forming member 20b with the central opening of the second housing. It is accommodated so as to be on a protruding portion formed so as to protrude from the bottom surface. In the embodiment of the present invention, the impeller rotating torque generating unit 3 is attached to the lower side of the second housing forming member 20b before the disposing step, but is not limited thereto, and may be attached after the sealing step. Good.

Next, the seal member 52 heated and expanded in the heat expansion step is inserted into the seal member accommodating groove 83b (the outer periphery of the cylindrical abutting portion 81b) of the second housing forming member 20b in a normal temperature state (25 ° C.). Deploy. At this time, the upper portion of the seal member 52 protrudes upward from the upper end surface of the abutting portion 81b. Since the depth of the seal member accommodating groove 83b is lower than the height of the seal member 52 at normal temperature, the seal member 52 is
There is no need for special positioning when disposing them. Then, the first housing forming member 20 is moved so that the contact surface 91a of the abutting portion 81a abuts on the contact surface of the abutting portion 81b.
a is put on the second housing forming member 20b. In this state, the butted portion 81a and the butted portion 81b, and the fixed member attaching portion 82a and the fixed member attaching portion 82b are in contact with each other without shifting in the radial direction. Also, the sealing member 52
Is housed in a space 83 formed between the seal member housing groove 83a and the housing groove 83b. The butting line 51 is located near the center of the inner peripheral surface of the seal member 52, The outer periphery of the butting portion 81 is covered. Note that the arrangement step is not limited to the above. For example, impeller 2
After the first housing forming member 20a is accommodated in the first housing forming member 20a, the seal member 52 is disposed on the outer periphery of the butting portion 81a of the first housing forming member 20a, and then the second housing forming member 20b is connected to the first housing forming member 20a. It may be arranged by covering over 20a.

Next, a process for sealing the butting line portion of the butting portion 81 in a liquid-tight and air-tight manner by contraction of the sealing member 52 will be described. By leaving the centrifugal liquid pump 1 assembled in the disposing step at room temperature, the heat-expanded seal member 52 is naturally cooled and contracted, whereby the inner diameter of the seal member 52 is reduced, and the butting line of the butted portion 81 is soon formed. It is shrink-fitted on the outer periphery of the part and finally seals the abutting line 51 part in a liquid-tight and air-tight manner. In other words, the sealing member 52 expanded by heating contracts as the temperature decreases, and the inner diameter decreases accordingly. Before the contraction is completed, the contraction portion 81 comes into close contact with the outer surface of the butting line portion, so that subsequent contraction (deformation) is suppressed. Therefore, the seal member 52 is fixed to the outer periphery of the abutting portion, that is, shrink-fitted in a state where contact stress acts between the inner peripheral surface of the sealing member 52 and the outer peripheral surface of the abutting portion.
Thereby, the contact surface between the butting portion 81a and the butting portion 81b is fixed and hermetically sealed without any gap. Accordingly, the housing 20 (blood chamber 24) is liquid-tightly and air-tightly sealed, so that even if the centrifugal liquid pump is embedded in the body for a long time, blood circulating in the housing 20 does not leak into the living body. Also, blood and the like in the living body do not enter the housing.

After the sealing step, a step of fixing the first housing forming member 20a and the second housing forming member 20b is performed. In the housing forming member combining step, the through holes 54 of the fixing member mounting portion of the first housing and the fixing member mounting holes 55 of the second housing forming member are combined so as to match. Then, the fixing member 53
Is inserted into the through-hole 54 of the fixing member mounting portion of the first housing, and is penetrated to reach the fixing member mounting hole 55 of the second housing forming member.
5, the first housing forming member 2
Oa and the second housing forming member 20b are completely fixed.

Also, the centrifugal liquid pump assembled as described above is at room temperature, which is about 10 ° C. lower than when implanted in the body, so that the contact stress generated between the sealing member 52 and the abutting portion is less than that of the body. It becomes larger than the contact stress at the time of embedding, and a load is applied between the seal member 52 and the abutting portion. Therefore, after assembling the centrifugal liquid pump, the contact stress generated between the seal member 52 and the abutting portion may be set to an appropriate value by placing the centrifugal liquid pump at a temperature to be implanted in the body. The seal member 52
When the housing is made of a titanium alloy or stainless steel, the yield point (proof strength) is sufficiently large, and there is no problem even if the housing is stored at room temperature.

In the embodiment, in the arrangement step,
Although the seal member 52 expanded by heating is arranged in the housing in the normal temperature state, the present invention is not limited to this. For example, before the disposing step, a step of cooling the first housing forming member 20a and the second housing forming member 20b to reduce the outer diameters of the butted portions 81a and 81b may be provided. Thus, the seal member 52 may be heated so as to have the required temperature difference, so that the first housing forming member 20a and the second housing forming member 2 are heated.
There is no need to raise the temperature of the seal member 52 as compared with the case where 0b is at room temperature. For this reason, the temperature change of the centrifugal liquid pump with respect to the normal temperature is reduced, and the influence on the internal components can be reduced. Although the method for sealing a medical device according to the present invention has been described above, the medical device is not limited to the centrifugal liquid pump, and the sealing method is not limited to the above method.

[0054]

The medical device of the present invention is a medical device having a housing comprising a first housing forming member and a second housing forming member combined with the first housing forming member. An annular butting line formed by combining the first housing forming member with the second housing forming member, wherein the medical device is provided with heat provided so as to cover the entire circumference of the butting line. An expandable metallic annular seal member, and the metallic annular seal member is disposed at the abutting line portion of the housing during heat expansion and contracts after cooling to seal the abutting line portion of the housing in a liquid-tight and air-tight manner. Is sealed. For this reason, since the first housing forming member and the second housing forming member are made liquid-tight and air-tight without welding, there is no distortion of the housing forming member due to welding, and the liquid is used without using an adhesive. Since it is tight and airtight, it can be used safely without elution of the adhesive.

The method for manufacturing a medical device according to the present invention is directed to a medical device having a housing comprising a first housing forming member made of metal and a second housing forming member made of metal combined with the first housing forming member. Manufacturing method, wherein the step of combining the first housing forming member and the second housing forming member and the step of combining the first housing forming member and the second housing forming member are formed. Disposing a metal annular seal member expanded by heating so as to cover a position to be an annular abutting line portion; and performing the housing forming member combining step and the seal member disposing step, and then performing the metal annular seal. Providing a sealing step of cooling the member to bring the sealing member into liquid-tight and air-tight contact with the outer surface of the abutting line portion of the housing. To have. For this reason, it is possible to easily and surely assemble the medical device between the first housing forming member and the second housing forming member in a liquid-tight and air-tight manner without using welding and an adhesive.

Further, the method for manufacturing a medical device of the present invention includes a housing including a first housing forming member made of metal and a second housing forming member made of metal combined with the first housing forming member. A method of manufacturing a medical device, wherein the first housing forming member includes a first housing forming member side annular seal member storage groove capable of storing an upper portion of a metal annular seal member, and wherein the second housing is formed. The forming member includes a second housing forming member side annular sealing member housing groove capable of housing a lower portion of the metal annular sealing member, and combines the first housing forming member and the second housing forming member. Thereby, the first housing forming member side annular seal member housing groove and the second housing forming member side annular seal member housing groove are formed. An annular seal member accommodating portion is formed, and the method for manufacturing a medical device is characterized in that the first housing forming member-side annular seal member accommodating groove and the second housing forming member-side annular seal member accommodating groove. Prepare a metal annular seal member having an inner diameter at the time of non-heating smaller than the inner diameter of, heating the metal annular seal member,
A metal annular sealing member heating step of making the inner diameter of the seal member larger than the inner diameter of the housing groove; and heating the heated metal annular seal member to the first housing forming member side annular seal member housing groove or A seal member disposing step of disposing the seal member in the second housing forming member side annular seal member receiving groove; and a first housing forming member or a second member on which the seal member is disposed by the seal member disposing step
A housing forming member combining step of combining the other housing forming member with the housing forming member, and a seal member cooling step of cooling the seal member while maintaining the combined state by the housing combining step. For this reason, it is possible to easily and surely assemble the medical device between the first housing forming member and the second housing forming member in a liquid-tight and air-tight manner without using welding and an adhesive.

A centrifugal liquid pump according to the present invention includes a housing formed by combining a first housing forming member having a blood inflow port and a second housing forming member having a blood outflow port, and a housing inside the housing. A centrifugal liquid pump provided with an impeller that rotates and feeds blood by centrifugal force at the time of rotation, wherein the housing is formed by combining the first housing forming member with the second housing forming member. The centrifugal liquid pump includes a thermally expandable metallic annular seal member provided so as to cover the entire circumference of the joint line, and the metallic annular seal is provided. The member is disposed at the abutting line portion of the housing during heat expansion, and contracts after cooling to make the abutting line portion of the housing liquid-tight. It is those that are air-tight seal.
For this reason, since the first housing forming member and the second housing forming member are made liquid-tight and air-tight without welding, there is no distortion of the housing forming member caused by welding.
In addition, since it is liquid-tight and air-tight without using an adhesive, it can be used safely without elution of the adhesive.

[Brief description of the drawings]

FIG. 1 is a front view of an embodiment in which the medical device of the present invention is applied to a centrifugal liquid pump.

FIG. 2 is a plan view of the centrifugal liquid pump shown in FIG.

FIG. 3 is a bottom view of a first housing forming member used in the centrifugal liquid pump of FIG. 1;

FIG. 4 is a plan view of the centrifugal liquid pump when a first housing forming member is removed from the centrifugal liquid pump.

FIG. 5 is an AA diagram of the centrifugal liquid pump shown in FIG. 1;
It is a line sectional view.

FIG. 6 is a vertical sectional view of the centrifugal liquid pump of FIG. 1;

FIG. 7 is a front view of a metal annular seal member used in the centrifugal liquid pump of FIG. 1;

FIG. 8 is a plan view of the metallic annular seal member shown in FIG. 7;

FIG. 9 is an explanatory diagram for explaining a centrifugal liquid pump of the present invention.

FIG. 10 is a longitudinal sectional view of another embodiment in which the medical device of the present invention is applied to a centrifugal liquid pump.

FIG. 11 is an explanatory diagram for explaining a sealing mechanism portion of the centrifugal liquid pump shown in FIG. 10;

FIG. 12 is a longitudinal sectional view of another embodiment in which the medical device of the present invention is applied to a centrifugal liquid pump.

FIG. 13 is an explanatory diagram for explaining a sealing mechanism portion of the centrifugal liquid pump shown in FIG. 12;

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Centrifugal liquid pump 2 Centrifugal liquid pump part 4 Impeller position control part 3 Impeller rotation torque generation part 20 Housing 20a First housing forming member 20b Second housing forming member 51 Butt line 52 Metallic annular seal member

Continued on the front page (72) Inventor Mitsutoshi Yaegashi 1500 Inoguchi, Nakai-machi, Ashigara-gun, Kanagawa Prefecture Terumo F-term (reference) 3H022 AA01 CA23 DA00 3H034 AA01 AA11 BB01 BB06 CC03 DD01 EE13 4C077 AA04 BB10 DD08 EE01 PP28 NN

Claims (9)

[Claims] 1. A medical device having a housing comprising a first housing forming member made of metal and a second housing forming member made of metal combined with the first housing forming member, wherein the housing comprises: An annular butting line formed by combining the first housing forming member with the second housing forming member, wherein the medical device is provided with thermal expansion provided so as to cover the entire circumference of the butting line. A metal annular seal member capable of being disposed at the abutting line portion of the housing during thermal expansion and contraction after cooling to make the abutting line portion of the housing liquid-tight and air-tight. A medical device characterized by being sealed. 2. The first housing forming member includes a first housing forming member side annular sealing member housing groove capable of housing an upper portion of the annular sealing member, and the second housing forming member includes: A first housing forming member is formed by combining the first housing forming member and the second housing forming member while providing a second housing forming member side annular sealing member housing groove capable of housing a lower portion of the annular sealing member. The medical device according to claim 1, wherein an annular seal member storage portion is formed by the member-side annular seal member storage groove and the second housing forming member-side annular seal member storage groove. 3. A method for manufacturing a medical device, comprising: a housing including a first housing forming member made of metal and a second housing forming member made of metal combined with the first housing forming member. The step of combining the first housing forming member and the second housing forming member, and the position of the annular butting line formed when the first housing forming member and the second housing forming member are combined. Disposing a metal annular seal member expanded by heating so as to cover, and performing the housing forming member combination step and the seal member disposing step, and then cooling the metal annular seal member. A medical device comprising a sealing step of bringing a sealing member into liquid-tight and air-tight contact with the outer surface of the abutting line portion of the housing. Manufacturing method of the tool. 4. A method for manufacturing a medical device having a housing comprising a first housing forming member made of metal and a second housing forming member made of metal combined with the first housing forming member, wherein: The first housing forming member includes a first housing forming member side annular sealing member housing groove capable of housing an upper portion of the metal annular sealing member, and the second housing forming member includes the metal annular sealing member. And a second housing forming member side annular seal member housing groove capable of housing a lower portion of the first housing forming member, and combining the first housing forming member and the second housing forming member to form a first housing forming member side annular ring. An annular seal member storage portion is formed by the seal member storage groove and the annular seal member storage groove on the second housing forming member side. In the method for manufacturing a medical device, the inner diameter at the time of non-heating is smaller than the inner diameter of the first housing forming member side annular seal member housing groove and the second housing forming member side annular seal member housing groove. Preparing a metallic annular seal member provided, heating the metallic annular seal member, making the inner diameter of the seal member larger than the inner diameter of the storage groove, and heating the metallic annular seal member. The metal annular sealing member is connected to the first
A seal member arranging step of disposing the seal member in the housing forming member side annular seal member housing groove or the second housing forming member side annular seal member housing groove, and forming the first housing in which the seal member is arranged by the seal member arranging step. Performing a housing forming member combining step of combining the other housing forming member with the member or the second housing forming member; and a sealing member cooling step of cooling the seal member while maintaining the combined state by the housing combining step. A method for manufacturing a medical device, comprising: 5. The method for manufacturing a medical device, further comprising a housing forming member cooling step of cooling and shrinking the first housing forming member and the second housing forming member before the seal member arranging step. The method for manufacturing a medical device according to claim 3, wherein 6. A housing formed by combining a metal first housing forming member having a blood inflow port and a metal second housing forming member having a blood outflow port, and a housing formed inside the housing. A centrifugal liquid pump having an impeller that sends blood by centrifugal force during rotation.
An annular butting line formed by combining the first housing forming member with the second housing forming member is provided, and the centrifugal liquid pump is provided so as to cover the entire circumference of the butting line. A heat-expandable metallic annular seal member, and the metallic annular seal member is disposed at the abutting line portion of the housing during thermal expansion, and contracts after cooling to liquid-tightly seal the abutting line portion of the housing. A centrifugal liquid pump that is hermetically sealed. 7. The first housing forming member includes a first housing forming member side annular sealing member housing groove capable of housing an upper portion of the annular sealing member, and the second housing forming member includes: A first housing forming member is formed by combining the first housing forming member and the second housing forming member while providing a second housing forming member side annular sealing member housing groove capable of housing a lower portion of the annular sealing member. 7. The centrifugal liquid pump according to claim 6, wherein the annular seal member housing portion is formed by the member side annular seal member housing groove and the second housing forming member side annular seal member housing groove. 8. The impeller includes a magnetic body inside,
The centrifugal liquid pump includes a rotor having a magnet for attracting a magnetic body of the impeller, an impeller rotation torque generating unit having a motor for rotating the rotor, and an impeller position control unit having an electromagnet for attracting the impeller. The centrifugal liquid pump according to claim 6 or 7, further comprising: 9. The metal annular seal member includes a first housing member rib extending inward from an upper inner surface of the seal member and a second rib extending inward from a lower inner surface of the seal member.
The first housing member includes a first housing-side recess for accommodating the first housing member rib of the seal member, and the second housing member includes A second housing-side recess is provided for accommodating a second housing member rib of the seal member, and the metal annular seal member is disposed at the abutting line portion of the housing during thermal expansion and contraction after cooling. The abutting line portion of the housing is liquid-tightly and air-tightly sealed, and the first housing member rib of the sealing member is housed in the first housing-side concave portion, and the second housing member of the sealing member is 9. The centrifugal liquid pump according to claim 6, wherein a rib is housed in the second housing-side recess.