JP2002224068A - Body surface added electrocardiogram automatic analyzer for determining electrocardiogram t wave repolarization abnormality - Google Patents
Body surface added electrocardiogram automatic analyzer for determining electrocardiogram t wave repolarization abnormalityInfo
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- JP2002224068A JP2002224068A JP2001030351A JP2001030351A JP2002224068A JP 2002224068 A JP2002224068 A JP 2002224068A JP 2001030351 A JP2001030351 A JP 2001030351A JP 2001030351 A JP2001030351 A JP 2001030351A JP 2002224068 A JP2002224068 A JP 2002224068A
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Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、心電図装置に関す
るものであり、特に突然死の原因となる重症不整脈の指
標である心室遅延電位(LP:Late Potent
ial)と同時に、同様に心電図上の重症不整脈の指標
である再分極過程を表現するT波の異常を自動解析する
ことができる体表面平均加算心電図装置に関するもので
ある。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an electrocardiogram device, and more particularly to a ventricular late potential (LP) which is an index of severe arrhythmia causing sudden death.
At the same time, the present invention relates to a body-surface-averaged electrocardiogram device capable of automatically analyzing a T-wave abnormality expressing a repolarization process which is also an index of a severe arrhythmia on an electrocardiogram.
【0002】[0002]
【従来の技術】心電図は図6に示すようにP波、R波、
T波、U波から構成されている。突然死の原因となる重
症不整脈を起こしやすい患者では心電図の脱分極を表す
QRS波の異常が心室遅延電位として検出され、再分極
過程を表現するT波の異常もあることが知られている。
従来上記のような心電図心室遅延電位を検出する装置は
公知であり、その一例を簡単に説明しておくと、図7は
心電図心室遅延電位検出装置のブロック図である。2. Description of the Related Art As shown in FIG.
It consists of a T wave and a U wave. It is known that in patients who are susceptible to severe arrhythmias that cause sudden death, abnormalities in the QRS wave representing the depolarization of the electrocardiogram are detected as ventricular delayed potentials, and there are also abnormalities in the T wave representing the repolarization process.
Conventionally, an apparatus for detecting the above-described ECG ventricular delayed potential is known, and an example thereof will be briefly described. FIG. 7 is a block diagram of an ECG ventricular delayed potential detecting apparatus.
【0003】図において1は増幅器、2はA/D変換
器、3はR波検出器、4は平均加算部、5は記憶部、6
は解析部、8は表示部、9は入力部、10は記憶部であ
り、身体に装着された電極から誘導されたXYZ誘導
(それぞれ胸部上の二ケ所からの誘導で、X:V5Rと
V5誘導、Y誘導:V1とLF、Z:V8とV3誘導の
三つの誘導である。なお、V5R、V5、V1、LF、
V3は胸部上の部位を示す公知の記号である)心電図
は、それぞれ増幅器1により増幅された後、A/D変換
器2により時系列ディジタルデータに変換され、その後
の処理は全てソフトウエアにより行われる。得られた心
電図信号のディジタルデータは、R波検出器3で検出さ
れたR波位置に同期して平均加算部4において平均加算
される。そのXYZ誘導平均加算心電図は記憶部5に記
憶されるとともに、解析部6において心室遅延電位の検
出が行われる。また、心電図を利用した再分極過程の解
析装置としては次の3種類の方法がある。数十個の誘
導(体表面マッピング)心電図を記録しその積分値の分
布から再分極過程の異常を検出しようとするもの、体
表面マッピング心電図を記録しその一次微分値が最大と
なる時間を計測しその分布から再分極過程の異常を検出
しようとするもの、標準12誘導心電図のT波の終了
時点までの時間を計測して再分極過程の異常を検出しよ
うとするもの等がある。上記のような心電図を測定する
装置は公知である。またこれらの再分極異常の検出はオ
ペレータの目視による用手的作動による所が多い。In the figure, 1 is an amplifier, 2 is an A / D converter, 3 is an R-wave detector, 4 is an average adder, 5 is a storage, 6
Is an analysis unit, 8 is a display unit, 9 is an input unit, and 10 is a storage unit. XYZ leads (leads from two places on the chest, respectively: X: V5R and V5) Induction, Y induction: V1 and LF, Z: Three inductions of V8 and V3, V5R, V5, V1, LF,
V3 is a known symbol indicating a part on the chest.) The electrocardiogram is amplified by an amplifier 1 and then converted into time-series digital data by an A / D converter 2. All subsequent processing is performed by software. Will be The digital data of the obtained electrocardiogram signal is averaged and added by the average adding section 4 in synchronization with the R-wave position detected by the R-wave detector 3. The XYZ lead averaged electrocardiogram is stored in the storage unit 5 and the analysis unit 6 detects a ventricular delayed potential. In addition, there are the following three types of analyzers for analyzing the repolarization process using an electrocardiogram. Record dozens of lead (body surface mapping) electrocardiograms and attempt to detect abnormalities in the repolarization process from the distribution of the integrated values. Record body surface mapping electrocardiograms and measure the time when the first derivative value is maximum. Some attempt to detect abnormalities in the repolarization process from the distribution, and others attempt to detect abnormalities in the repolarization process by measuring the time until the end of the T-wave of the standard 12-lead ECG. Devices for measuring an electrocardiogram as described above are known. In addition, detection of these repolarization abnormalities is often performed by manual operation by an operator.
【0004】[0004]
【発明が解決しようとする課題】しかしながら、前述し
た標準12誘導心電図からの検出では、目視によるT波
の終了時点の決定が困難である。また体表面マッピング
心電図を記録する方法は数十個の電極を装着しなけらば
ならず煩雑であった。そこで、本発明は、従来心電図上
突然死の原因となる重症不整脈の予知に用いらているX
YZ誘導平均加算心電図による心室遅延電位の測定と同
時に、同XYZ平均加算誘導心電図を用いてそのT波部
分の最大エントロピー法(MEM:Maximum E
ntropy Method)による解析を行い再分極
過程の異常を示す指標をMEMvalueとして表示す
ることができる体表面加算心電図自動解析装置を提供す
ることにより、上記問題点を解決することを目的とす
る。However, in the detection from the standard 12-lead electrocardiogram, it is difficult to visually determine the end point of the T wave. Also, the method of recording a body surface mapping electrocardiogram has to be equipped with several tens of electrodes, which is complicated. Therefore, the present invention provides a method for predicting severe arrhythmia that causes sudden death on an electrocardiogram.
Simultaneously with the measurement of the ventricular delay potential by the YZ-lead averaged electrocardiogram, the maximum entropy method (MEM: Maximum E) of the T-wave portion using the same XYZ average-lead electrocardiogram.
An object of the present invention is to solve the above-mentioned problem by providing an automatic body surface addition electrocardiogram analysis apparatus capable of performing analysis by tropy method) and displaying an index indicating an abnormality in a repolarization process as a MEM value.
【0005】[0005]
【課題を解決するための手段】本発明が採用した技術解
決手段は、生体に装着する電極から誘導される心電図信
号の増幅入力手段と、該入力手段に接続されXYZ誘導
心電図をデジタル変換するアナログデジタル変換手段
と、前記XYZ誘導心電図のR波発生位置を検出するR
波検出手段と、R波検出手段3で検出されたR波位置に
同期して平均加算する平均加算手段と、前記平均加算手
段で求めたXYZ誘導平均加算心電図を記憶する記憶手
段と、前記平均加算手段で求めたXYZ平均加算誘導心
電図を基に心室遅延電位を解析する心室遅延電位解析手
段と、R波検出位置から自動的に決定されるT波解析区
間に対して解析を行う心電図T波解析手段と、解析結果
を出力する出力手段を具備することを特徴とする心電図
T波再分極異常を求める体表面加算心電図自動解析装置
である。また、前記心電図T波解析手段は、R波位置か
らある一定時間の区間のXYZそれぞれの波形を1次微
分し、求めた波形について最大エントロピーによる解析
を行い予測誤差フィルター係数を得たのち、その予測誤
差フィルター係数の平均二乗値を求めるべく構成されて
いることを特徴とする体表面加算心電図自動解析装置で
ある。Means for Solving the Problems The technical solution adopted by the present invention is an input means for amplifying an electrocardiogram signal induced from an electrode mounted on a living body, and an analog device connected to the input means for digitally converting an XYZ lead electrocardiogram. Digital converting means for detecting an R-wave generation position of the XYZ lead electrocardiogram;
A wave detecting means, an average adding means for performing an average addition in synchronization with the R-wave position detected by the R-wave detecting means 3, a storage means for storing an XYZ lead averaged added electrocardiogram obtained by the average adding means, Ventricular delayed potential analyzing means for analyzing a ventricular delayed potential based on the XYZ average addition lead electrocardiogram obtained by the adding means, and an electrocardiogram T-wave for analyzing a T-wave analysis section automatically determined from the R-wave detection position An automatic body surface addition electrocardiogram analysis apparatus for obtaining an electrocardiogram T-wave repolarization abnormality, comprising an analysis means and an output means for outputting an analysis result. In addition, the electrocardiogram T-wave analysis means performs first-order differentiation of each of the XYZ waveforms in a certain period of time from the R-wave position, analyzes the obtained waveform by the maximum entropy to obtain a prediction error filter coefficient, and An automatic body surface addition electrocardiogram analysis apparatus characterized in that it is configured to obtain a mean square value of a prediction error filter coefficient.
【0006】[0006]
【発明の実施の形態】以下、図面を参照しながら本発明
の実施の形態について説明すると図1は、本実施形態に
係る装置のブロック図である。なお、先述した従来装置
と同じ機能を有する構成要素は同じ符号を使用してい
る。図1において、1は増幅入力手段、2はA/D変換
手段、3はR波検出手段、4は平均加算手段、5は記憶
手段、6は心室遅延電位解析手段、7は心電図T波解析
手段、8は表示手段(出力手段)、9は出力手段、10
は記憶手段(出力手段)であり、これらからなる本心電
図測定装置は、従来装置と比較して心電図T波解析手段
を付加した点に大きな特徴がある。そして、増幅入力手
段を除いた上記各手段はコンピュータにより構成する。BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a block diagram of an apparatus according to an embodiment of the present invention. Components having the same functions as those of the above-described conventional device use the same reference numerals. In FIG. 1, 1 is an amplification input means, 2 is an A / D conversion means, 3 is an R wave detection means, 4 is an average addition means, 5 is a storage means, 6 is a ventricular delayed potential analysis means, and 7 is an electrocardiogram T wave analysis. Means, 8 means display means (output means), 9 means output means, 10 means
Is a storage means (output means), and the present electrocardiogram measuring apparatus is characterized by adding an electrocardiogram T-wave analyzing means as compared with the conventional apparatus. Each of the above units except for the amplification input unit is constituted by a computer.
【0007】この装置では、身体に装着した電極からの
誘導されたXYZ誘導心電図は、それぞれ増幅手段1に
より増幅された後、A/D変換手段2により時系列ディ
ジタルデータに変換され、その後の処理は全てソフトウ
エアにより行われる。得られた心電図信号のディジタル
データは、R波検出手段3で検出されたR波位置に同期
して平均加算部において平均加算される。そのXYZ誘
導平均加算心電図は記憶手段5に記憶される。また同時
に心室遅延電位解析手段6において心室遅延電位が検出
され、心電図T波解析手段7内で後述する態様でT波の
再分極過程の異常処理が行われる。なお、コンピュータ
を使用しない場合には専用回路にて装置構成することも
可能である。In this device, the XYZ lead electrocardiograms guided from the electrodes mounted on the body are respectively amplified by the amplifying means 1, then converted into time-series digital data by the A / D converting means 2, and then processed. Are all performed by software. The digital data of the obtained electrocardiogram signal is averagely added in an average adding section in synchronization with the R-wave position detected by the R-wave detecting means 3. The XYZ lead averaged electrocardiogram is stored in the storage means 5. At the same time, the ventricular delayed potential analyzing means 6 detects the ventricular delayed potential, and the electrocardiogram T-wave analyzing means 7 performs abnormal processing of the T-wave repolarization process in a manner described later. When a computer is not used, the device can be configured with a dedicated circuit.
【0008】心電図T波解析手段7内での処理を図2に
示すフローチャートに基づいて説明する。なお、ここで
の説明で使う図3および図4はT波解析手段での出力結
果であり、図3は健康な正常人、図4は心筋梗塞症で致
死性の心室頻拍症を発症した患者のものである。図2
中、ステップ1において、XYZ誘導平均加算心電図に
おいてR波位置からある一定時間をT波解析区間として
抽出する(図3および図4のA参照:2本の破線の間R
1、R2が解析区間である)。ステップ2において、そ
のT波解析区間を1次微分する。ステップ3において、
ステップS2で求めたXYZそれぞれの波形について後
述する最大エントロピー法による解析を行い、予測誤差
フィルター係数を得る。同時にMEMによるパワースペ
クトルを計算する。ステップ4において得られたXYZ
それぞれからの予測誤差フィルター係数の平均二乗値
(RMS:Root Mean Sequare)を求
める(図3および図4のD参照)。ステップ5において
MEMvalueとして出力する(図3および図4のF
参照)。同時にMEMによるパワースペクトル(図3お
よび図4のBおよびC参照)とその計測値(図3および
図4のE参照)を出力する。The processing in the electrocardiogram T-wave analysis means 7 will be described with reference to the flowchart shown in FIG. 3 and 4 used in the description here are the output results of the T-wave analysis means. FIG. 3 shows a healthy normal person, and FIG. 4 shows a case of fatal ventricular tachycardia due to myocardial infarction. It belongs to the patient. FIG.
In step 1, a certain time from the R wave position in the XYZ lead averaged ECG is extracted as a T wave analysis section (see A in FIGS. 3 and 4: R between two broken lines).
1, R2 is an analysis section). In step 2, the T wave analysis section is first differentiated. In step 3,
The XYZ waveforms obtained in step S2 are analyzed by the maximum entropy method described later to obtain prediction error filter coefficients. At the same time, the power spectrum by MEM is calculated. XYZ obtained in step 4
A root mean square (RMS) of the prediction error filter coefficient from each of them is obtained (see D in FIGS. 3 and 4). In step 5, output as MEM value (F in FIGS. 3 and 4)
reference). At the same time, the power spectrum (see B and C in FIGS. 3 and 4) and its measured value (see E in FIGS. 3 and 4) by the MEM are output.
【0009】なお、m次のX、Y、Z波形からの予測誤
差フィルター係数をγx1γx2・・・γxm、γy1γy2・・
・γym、γz1γz2・・・γzmとすると平均二乗値(RM
S)は次の通りとなる。 √(γx1 2 +γy1 2 +γz1 2 )+√(γx2 2 +γy2 2 +
γz2 2 )+・・・・・+√(γxm 2 +γym 2 +γzm 2) また、図3および図4において、そのパワースペクトル
(図3および図4のBおよびC参照)、パワースペクト
ルの計測値(図3および図4のE参照)も参考にするが
FのMEMvalueが5以下の値となる患者では再分
極過程に異常があると判断する。上記ステップ1におけ
る解析区間の決定、ステップ2における1次微分処理の
有無、ステップ3における予測誤差フィルター係数の次
数はオペレータにより決めることができる。また最大エ
ントロピー法による解析はBurg法で行った。以下に
Burg法のアルゴリズムを示す。 .. Γ x1 γ x2 ... Γ xm , γ y1 γ y2 ...
・ If γ ym , γ z1 γ z2・ ・ ・ γ zm , the mean square value (RM
S) is as follows. √ (γ x1 2 + γ y1 2 + γ z1 2 ) + √ (γ x2 2 + γ y2 2 +
γ z2 2) + ····· + √ (γ xm 2 + γ ym 2 + γ zm 2) Further, in FIGS. 3 and 4, the power spectrum (see B and C of FIG. 3 and FIG. 4), power spectrum 3 (see FIG. 3 and FIG. 4E), the patient whose F MEMvalue is 5 or less is judged to have an abnormality in the repolarization process. The determination of the analysis section in step 1, the presence or absence of the first-order differentiation process in step 2, and the order of the prediction error filter coefficient in step 3 can be determined by the operator. The analysis by the maximum entropy method was performed by the Burg method. The Burg method algorithm is shown below.
【0010】[0010]
【数1】 C0 C1 C2・・・Cm はm次の自己相関関数で予測誤
差フィルター係数γ1 γ 2 ・・・γm に信号を前向きに
通す場合と逆向きに通す場合の平均出力Pm を最小とす
るという条件を加え上の式を解き予測誤差フィルター係
数を求める。以上の処理により、本発明では、従来の心
室遅延電位の検出に用いられたXYZ平均加算誘導心電
図T波部分の最大エントロピー法による解析を行うこと
ができ、容易に再分極過程の異常を示す指標をMEMv
alueとして表示することができる。(Equation 1)C0C1C2 ... CmIs the m-th order autocorrelation function and the prediction error
Difference filter coefficient γ1γ Two... γmSignal forward
Average output P when passing in the opposite direction to passingmMinimize
Solves the above equation and adds the prediction error filter
Find the number. According to the above processing, the present invention
XYZ average addition lead electrocardiogram used for detection of ventricular delayed potential
Analyzing the T-wave part by the maximum entropy method
MEMv
It can be displayed as "alue".
【0011】以上、本発明の実施の形態について説明し
てきたが、本発明はその精神または主要な特徴から逸脱
することなく、他のいかなる形でも実施できる。そのた
め、前述の実施形態はあらゆる点で単なる例示にすぎず
限定的に解釈してはならない。たとえば、T波の解析手
法はMEMに限定されず、同様な解析ができる手法であ
れば他の手法(Yule−Walker法)を採用する
ことができる。Although the embodiments of the present invention have been described above, the present invention can be embodied in any other forms without departing from the spirit or main features thereof. Therefore, the above-described embodiment is merely an example in every aspect and should not be interpreted in a limited manner. For example, the analysis method of the T-wave is not limited to MEM, and another method (Yule-Walker method) can be adopted as long as it can perform similar analysis.
【0012】[0012]
【発明の効果】上記のように、本発明によれば、心室頻
拍等重症不整脈の指標である心室遅延電位の検出と同検
出に用いられたXYZ平均加算誘導心電図T波部分の最
大エントロピー法による解析を行うことで、その異常を
示す指標をMEMvalueとして表示することが可能
となり、心室頻拍等重症不整脈を持っている患者の再分
極過程の異常を容易に検出でき、突然死の予知に有用で
ある。As described above, according to the present invention, a ventricular delayed potential which is an index of ventricular tachyarrhythmia such as ventricular tachyarrhythmia is detected, and a maximum entropy method of the XYZ average addition lead electrocardiogram T wave portion used for the detection is used. By performing the analysis according to the above, it becomes possible to display an index indicating the abnormality as MEMvalue, and it is possible to easily detect abnormalities in the repolarization process of a patient having a severe arrhythmia such as ventricular tachycardia, and to predict sudden death. Useful.
【図1】本発明の装置に関するブロック図である。FIG. 1 is a block diagram related to the apparatus of the present invention.
【図2】心電図T波解析手段内でのフローチャートであ
る。FIG. 2 is a flowchart in the electrocardiogram T-wave analysis means.
【図3】T波解析手段での出力(健康な正常人)であ
る。FIG. 3 is an output from a T-wave analysis unit (a healthy normal person).
【図4】T波解析手段での出力(心筋梗塞症で致死性の
心室頻拍症を発症した患者)である。FIG. 4 is an output from a T-wave analysis unit (a patient who developed fatal ventricular tachycardia due to myocardial infarction).
【図5】心室遅延電位解析手段の出力である。 FIG. 5 is an output of a ventricular delayed potential analyzer .
【図6】正常な心電図である。FIG. 6 is a normal electrocardiogram.
【図7】従来の心室遅延電位検出装置のブロック図であ
る。FIG. 7 is a block diagram of a conventional ventricular delayed potential detecting device.
1 増幅入力手段 2 A/D変換手段 3 R波検出手段 4 平均加算手段 5 記憶手段 6 心室遅延電位解析手段 7 心電図T波検出手段 8 表示手段 9 入力手段 10 記憶手段 REFERENCE SIGNS LIST 1 amplification input means 2 A / D conversion means 3 R wave detection means 4 average addition means 5 storage means 6 ventricular delayed potential analysis means 7 electrocardiogram T wave detection means 8 display means 9 input means 10 storage means
Claims (2)
図信号の増幅入力手段と、該入力手段に接続されXYZ
誘導心電図をデジタル変換するアナログデジタル変換手
段と、前記XYZ誘導心電図のR波発生位置を検出する
R波検出手段と、R波検出手段3で検出されたR波位置
に同期して平均加算する平均加算手段と、前記平均加算
手段で求めたXYZ誘導平均加算心電図を記憶する記憶
手段と、前記平均加算手段で求めたXYZ平均加算誘導
心電図を基に心室遅延電位を解析する心室遅延電位解析
手段と、R波検出位置から自動的に決定されるT波解析
区間に対して解析を行う心電図T波解析手段と、解析結
果を出力する出力手段を具備することを特徴とする心電
図T波再分極異常を求める体表面加算心電図自動解析装
置。1. An amplification input means for an electrocardiogram signal induced from an electrode mounted on a living body, and an XYZ connected to the input means.
Analog-to-digital conversion means for digitally converting a lead electrocardiogram, R-wave detection means for detecting an R-wave generation position of the XYZ lead electrocardiogram, and averaging for averaging in synchronization with the R-wave position detected by the R-wave detection means 3 Addition means, storage means for storing the XYZ lead averaged addition electrocardiogram obtained by the average addition means, and ventricular delay potential analysis means for analyzing a ventricular delay potential based on the XYZ average addition lead electrocardiogram obtained by the average addition means. An electrocardiogram T-wave repolarization abnormality, comprising: an electrocardiogram T-wave analysis means for analyzing a T-wave analysis section automatically determined from an R-wave detection position; and an output means for outputting an analysis result. Surface electrocardiogram automatic analyzer that calculates
ある一定時間の区間のXYZそれぞれの波形を1次微分
し、求めた波形について最大エントロピーによる解析を
行い予測誤差フィルター係数を得たのち、その予測誤差
フィルター係数の平均二乗値を求めるべく構成されてい
ることを特徴とする請求項1に記載の体表面加算心電図
自動解析装置。2. The electrocardiogram T-wave analysis means first-order differentiates each of the XYZ waveforms in a certain time interval from the R-wave position, analyzes the obtained waveform by the maximum entropy, and obtains a prediction error filter coefficient. 2. The automatic electrocardiogram analyzing apparatus according to claim 1, wherein the apparatus is further configured to obtain a mean square value of the prediction error filter coefficient.
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JP2001030351A JP2002224068A (en) | 2001-02-07 | 2001-02-07 | Body surface added electrocardiogram automatic analyzer for determining electrocardiogram t wave repolarization abnormality |
PCT/JP2002/000779 WO2002062217A1 (en) | 2001-02-07 | 2002-01-31 | Body surface multi-induction cardiograph and analysis method using the same |
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JP2001030351A JP2002224068A (en) | 2001-02-07 | 2001-02-07 | Body surface added electrocardiogram automatic analyzer for determining electrocardiogram t wave repolarization abnormality |
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EP2752157A1 (en) | 2013-01-08 | 2014-07-09 | Nihon Kohden Corporation | Biological signal averaging processing device |
JP2014128424A (en) * | 2012-12-28 | 2014-07-10 | Fukuda Denshi Co Ltd | Electrocardiogram examination equipment, electrocardiography and electrocardiogram examination program |
JP2014128425A (en) * | 2012-12-28 | 2014-07-10 | Fukuda Denshi Co Ltd | Electrocardiogram information processor, electrocardiogram information processing method, and electrocardiogram information processing program |
US8874199B2 (en) | 2006-05-26 | 2014-10-28 | Fukuda Denshi Co., Ltd. | Electrocardiogram analyzer |
-
2001
- 2001-02-07 JP JP2001030351A patent/JP2002224068A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US8874199B2 (en) | 2006-05-26 | 2014-10-28 | Fukuda Denshi Co., Ltd. | Electrocardiogram analyzer |
JP2014128424A (en) * | 2012-12-28 | 2014-07-10 | Fukuda Denshi Co Ltd | Electrocardiogram examination equipment, electrocardiography and electrocardiogram examination program |
JP2014128425A (en) * | 2012-12-28 | 2014-07-10 | Fukuda Denshi Co Ltd | Electrocardiogram information processor, electrocardiogram information processing method, and electrocardiogram information processing program |
EP2752157A1 (en) | 2013-01-08 | 2014-07-09 | Nihon Kohden Corporation | Biological signal averaging processing device |
JP2014132928A (en) * | 2013-01-08 | 2014-07-24 | Nippon Koden Corp | Biological signal averaging processing apparatus |
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