JP2002187849A - Hypotensive agent obtained from seaweed ash - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an antihypertensive originating from natural products with high safety and economy by using natural product, particularly incinerated brown algae ash or an extract therefrom as an active ingredient in stead of conventional synthesized chemicals. SOLUTION: Seaweed incinerated ash and/or an extract thereof is used as an active ingredient to provide the objective seaweed ash antihypertensive. The raw material of the seaweed ash is a brown algae, which are incinerated at 200-1,000 deg.C whereby the objective seaweed ash is prepared.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a blood pressure reducing agent derived from a natural product having both safety and economy useful for prevention and treatment of hypertension (hereinafter, may be simply referred to as a blood pressure reducing agent).
About.

[0002] More specifically, the present invention provides a safety and economical method using seaweed ash obtained by incineration (carbonization) of natural products, particularly brown algae, as an active ingredient, instead of the conventional antihypertensive agent of a chemically synthesized product. The present invention relates to an antihypertensive agent derived from a natural product, which is excellent in natural environment.

[0003]

BACKGROUND OF THE INVENTION Hypertension is a risk factor that often causes serious symptoms, such as in arteriosclerosis from hypertension.

[0004] It is known to use natural products such as Chinese herbal medicines as agents for hypertension, but generally, chemical-synthetic antihypertensive agents are frequently used.

[0005] Examples of this type of chemically synthesized product include angiotensin converting enzyme inhibitors, β-receptor blockers and α-receptor blockers that suppress sympathetic nerve excitation, calcium antagonists, antihypertensive diuretics, and the like. There is a feature in the mechanism of action,
Used as such. However, these chemically-synthesized drugs always have side effects, and there is no known side-effect-free drug to date.

[0006]

DISCLOSURE OF THE INVENTION The present invention overcomes the limitations of the prior art described above, and provides a natural alternative to conventional hypertension drugs that can be easily taken and drunk in the form of healthy tea or the like on a daily basis. It is intended to provide a substance-based antihypertensive agent.

[0007] As described above, conventional hypertension drugs are basically derived from chemical synthesis, which can be said to be toxic substances with strong side effects, and their use is under the guidance of a doctor or pharmacist. That must be used.

The inventor of the present invention has enthusiastically studied to solve the above-mentioned disadvantages of the conventional drug for hypertension. As a result, seawater algae, especially those obtained by hot water extraction of ash (carbonized material) of brown algae such as kelp, can be obtained by using conventional chemical synthetic products,
It has been found that it has an excellent action and effect as an antihypertensive agent as compared with Chinese herbs and the like.

The present invention has been completed based on the above findings, and the present invention provides a blood pressure lowering agent which has no side effects, is excellent in safety and economy, and has excellent antihypertensive properties.

[0010]

In summary, the present invention is directed to a seaweed ash-based antihypertensive agent comprising seaweed ash obtained by incineration of seaweed and / or an extract of the seaweed ash as an active ingredient. It is about.

Hereinafter, the technical constitution and the embodiments of the present invention will be described in detail.

The natural product-derived antihypertensive agent according to the present invention comprises:
It has been developed based on the following findings and experimental methods of the present inventors. First, the present inventor believes that hypertension does not occur in a short period of time, so that merely evaluating the vasodilatory effect does not lead to the development of a suitable natural product antihypertensive agent. For this reason, the present inventor has not yet fully clarified the relationship between excessive salt intake and hypertension, but noted that there are many hypertensive patients in the Tohoku region where salt intake is high. Generally, it is considered that the intake of salt is preferably 10 g or less per day, but there are some cases where the intake is more than that, and especially in the Tohoku region, there is no improvement.

As described above, the present inventor has proposed, as an experimental model, a deoxycorticosteroacetate acetate, a hormone that stores sodium (Na) in the body, as an experimental model for developing a qualifying natural product-derived antihypertensive agent. (D
Using a rat model of DOCA-salt loading, which was injected with OCA) and loaded with salt, a method of drinking the sample (test article) for about one month was adopted.

The antihypertensive agent of the present invention contains seaweed ash obtained by incineration (carbonization) of seaweed as an active ingredient. In the present invention, seaweed ash is used as it is, or is used as a form of an extract or an extract (powder) obtained by extracting seaweed ash with a predetermined extraction medium.

In the antihypertensive agent of the present invention, the seaweed used as a raw material of seaweed ash includes brown algae such as seaweed, kelp, mozuku, alame, hijiki and hondawara, and red algae such as tengusa, and the former is particularly preferable. is there.

In the present invention, the conditions for incineration of seaweed (calcination temperature and calcination time) may be appropriately set. As the ashing condition, for example, a condition of 200 to 1000 ° C. for 2 to 4 hours may be adopted. More specifically, seaweed, kelp, Honda straw, etc. as raw materials are collected, washed with water, dried, roughly cut, and then subjected to an incinerator (Yamato Scientific Co., Ltd., FP32 type).
Ashing treatment may be performed at 00 ° C. for 2 hours.

In the present invention, incineration (carbonization) of seaweed raw material
Although the product can be taken as it is, generally, a product (liquid or extract) obtained by extracting with hot water and extracting an extraction component from seaweed ash can be used. When the above-mentioned extraction method is employed, in addition to hot water extraction, a desired extraction medium such as alcohol or hydroalcohol may be used, and the extract may be used as it is or in the form of an extract (solid powder). .

Although the seaweed ash-based antihypertensive agent of the present invention exhibits an excellent antihypertensive effect as described later, its mechanism of action has not been sufficiently elucidated. Although not speculated, the seaweed ash antihypertensive agent of the present invention contains extremely abundant mineral components, and it is considered that these various mineral components are effectively acting.

[0019]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples. It goes without saying that the present invention is not limited to the following embodiments.

<Experimental Method> (1) A rat model of DOCA-salt load was used as an experimental model. That is, a male SD weighing 200-220 g
The left kidney of the rat was excised, and three days later, 10 mg / kg subcutaneous injection of deoxycorcorticosterone acetate (DOCA), a hormone that stores sodium in the body, was made every 5 days. (2) A subject (a test antihypertensive in the form of an extract) was placed in drinking water of a rat, and the change in blood pressure was measured throughout the day. In addition, 1% saline was used for the control group. (3) An autopsy was performed on the 28th day after the end of the experiment, and the weight of the heart and liver was measured. Further, a significant difference test for the 1% salt intake group was performed by the Dunnett method.

<Preparation of antihypertensive agent> A seaweed (brown algae) was heated at 450 ° C. to 6 ° C using an incinerator (FP32 type, manufactured by Yamato Scientific Co., Ltd.).
Ashing treatment was performed at 50 ° C. for 1 hour. Next, the seaweed ash obtained as described above is usually used as a decoction, with a dose of 3 to 5 g as a guide. A body (test hypotensive) was prepared.

<Experimental Results> As a comparative experiment, a crude drug "Kagikazura" (crude drug name, Chotohook, Chocolate, Uncaria thy), which is said to have a blood pressure lowering effect,
nchophylla (Rubiaceae fishing thorn) was investigated. Necropsy was performed 28 days after the end of the experiment,
Heart and kidney weights were measured. The measured values are shown as an average value and a standard error.

(1). Experimental results (measurement of change in blood pressure): The results are shown in Table 1 below. In Table 1, (*) indicates that there is a significant difference from the 1% salt intake group at a 5% risk rate, and (**) indicates that the 1% salt water intake group has a 1% risk rate. Means that there is a significant difference from

[0024]

[Table 1]

(2). Experimental Results (Measurement of Heart and Kidney Weight): Necropsy was performed on the 28th day from the start of the experiment, and the weight of the heart and kidney was measured. At the time of hypertension due to sodium storage, it is considered that in many cases, any organ is overloaded due to an increase in body fluid and becomes enlarged. The results are shown in Table 2 below. The meanings of the (*) and (**) marks are the same as in Table 1 above.

[0026]

[Table 2]

<Acute toxicity test> Acute toxicity was tested using mice. That is, a ddY male mouse (weight about 20)
g) was administered orally at a dose of 2000 mg / kg capable of physically administering a subject (test antihypertensive agent) in groups of 10 animals.
Water was provided ad libitum and observed for life and death for one week. As a result, none of them died and none showed abnormal behavior.

[0028]

As is evident from Tables 1 and 2, the decoction of seaweed ash (3 g to 5 g) was drunk daily by a DOCA-salt-loaded hypertensive rat model to increase blood pressure significantly. Not only that, it can particularly suppress the enlargement of the liver.

In recent years, a detailed study has been conducted on the pathological condition of a DOCA hypertension model, and the hypertension is caused by an increase in endothelin, which is an in vivo peptide of vasoconstriction. Therefore, the seaweed ash extract of the present invention (blood pressure reducing agent)
Is presumed to have an action of suppressing the production of endothelin.

The antihypertensive agent of the present invention utilizes an active ingredient (extract or extract) of seaweed ash. To date, the habit of drinking seaweed ash as a tea has not been known at all, but its drinking should be promoted from the viewpoint of prevention and treatment of the onset of hypertension, which is a major risk factor for cardiovascular diseases.

The seaweed itself, for example, brown algae, which is a raw material of the antihypertensive agent of the present invention, is excellent in regenerative ability, excellent in resources and economical. Therefore, the present invention provides a natural product-derived antihypertensive agent which is excellent in safety, economical efficiency, as well as efficacy, and its significance is significant.

Claims (3)

[Claims] 1. A seaweed ash-based antihypertensive agent containing seaweed ash obtained by incineration of seaweed and / or an extract of the seaweed ash as an active ingredient. 2. The raw material of seaweed ash is brown algae.
The seaweed ash blood pressure lowering agent according to the above. 3. The method of claim 1, wherein the seaweed ash is a raw material of seaweed at 200 ° C.
The seaweed ash-based antihypertensive agent according to claim 1, which is obtained by incineration at 0 ° C.