JP2002161001A - Disinfectant - Google Patents

Abstract

PROBLEM TO BE SOLVED: To solve the problems of the conventional disinfectants that since they includes a large amount of high-volatility alcohol, their microbicidal power is lowered, the persistency lowered, and in addition the hand skin is roughened by the defatting action of the alcohol and the roughened skin acts as a culture medium a for proliferation of microorganisms and causes propagation of adhered the microorganisms. SOLUTION: The objective disinfectant is prepared by allowing 0.001-1 wt.% of a disinfectant boiling at a temperature higher than 120 deg.C to dissolve in a water-soluble solvent that boils at a temperature of >=120 deg.C and is in the liquid form at ordinary temperature. When this disinfectant composition is applied to skins, the oily coating layer of the water-soluble solvent including disinfectant components is formed on the surfaces of fingers and body skins whereby the microbicidal power is maintained and hands and body skins are prevented from being roughened by defatting action caused by lower alcohols.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a disinfectant which can be used as a disinfectant for disinfecting and disinfecting fingers, skin, etc., and for other general environments, as well as for disinfecting cooling water for machining and preventing spoilage. It is about.

[0002]

2. Description of the Related Art At present, disinfectants for fingers and skin are approved in Japan as (1) alcohol-based, (2) benzalkonium chloride-based surfactants, (3) Chlorhexidine gluconate, which is roughly classified into three types, the disinfectants (2) and (3) described above are used in liquids containing a large amount of alcohol, particularly ethanol, of about 80 to 83%. 0.05 germicidal ingredients
Approximately 0.1% is dissolved, and each contains a large amount of ethanol. Thus, the reason why ethanol is used in a large amount as a disinfectant is (1) large bactericidal activity against various kinds of bacteria, (2) quick action, and (3) permeability to skin and substance surfaces. (4) Inexpensiveness is characteristic of ethanol. Due to this feature, ethanol is widely used as a disinfectant, especially as a general environmental disinfectant.

[0003] However, ethanol has a boiling point of 78 ° C.
With a conventional disinfectant containing a large amount of ethanol, the ethanol evaporates and dries in about 3 to 4 seconds after application, and the sustainability of the sterilizing power of ethanol cannot be expected. Therefore, the bacteria that did not die and survived during the evaporation of the ethanol began to grow immediately after the evaporation of the ethanol. In the case of disinfectants in which a surfactant such as benzalkonium chloride or a bactericidal component such as chlorhexidine gluconate is dissolved in an ethanol solution, the content approved as a hand disinfectant is 0.05% for benzalkonium chloride. Chlorhexidine gluconate is 0.1%, and since these dried products are solid, after the ethanol in which the disinfecting component is dissolved is evaporated and dried, the powder of the disinfecting agent is turned into powder. As a result, the sterilizing power cannot be maintained on the entire surface of the application surface, and after the ethanol is evaporated and dried, the bacteria that have not survived but survived immediately start to proliferate.

Further, since ethanol has a high degreasing power, when a conventional disinfectant containing a large amount of ethanol is used for disinfecting fingers and skin, it may cause rough hands and rough skin.
Furthermore, since the rough skin serves as a growth medium for bacteria, infection and propagation of adherent bacteria therefrom become a problem.

[0005]

DISCLOSURE OF THE INVENTION In view of the above, the present invention provides a disinfectant which does not have the problem of rough hands and rough skin due to degreasing even when used for disinfection of fingers and skin, and has excellent sustainability of bactericidal activity. Is to be provided.

[0006]

In order to achieve the above object, the present inventor has made various studies and as a result, dissolves a disinfectant in a high-boiling solvent without using alcohol to obtain a disinfectant. As a result, even when used for disinfecting fingers and skin, it was possible to obtain a disinfectant having excellent germicidal activity without causing rough hands and rough skin. That is, the disinfectant according to the present invention is obtained by dissolving 0.5 to 80% by weight of a water-soluble solvent that is liquid at room temperature at a boiling point of 120 ° C. or higher, and dissolving a disinfectant having a boiling point of 120 ° C. or higher at 0.001 to 1% by weight. It is obtained by dissolving.

According to the disinfectant of the present invention as described above, even after the water in the aqueous solution in which the germicide is dissolved is evaporated and dried, the high-boiling water-soluble solvent in which the germicide is dissolved remains oily. By forming a film and coating the surface of the object to be disinfected, such as fingers and skin, the bactericidal power is maintained, and the roughening of hands and skin due to degreasing can be prevented, and the bactericidal power of the conventional alcohol-based disinfectant is maintained. And the problem of rough hands and rough skin can be solved.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The disinfectant used in the disinfectant of the present invention is preferably selected from known disinfectants conventionally used for pharmaceuticals and quasi-drugs.
Among these disinfectants, the disinfectants that can be used in the present invention have a boiling point of 120 ° C. or higher. The disinfectant needs to be soluble in a water-soluble solvent having a boiling point of 120 ° C. or higher, which will be described later. Examples of such a bactericide include benzalkonium chloride (boiling point 200 ° C.), chlorhexidine gluconate (boiling point 195 ° C.), benzethonium chloride (boiling point 200 ° C.), acrinol (melting point 23)
5 ° C.), benzoic acid (boiling point: 249 ° C.), alkyldiaminoethylglycine hydrochloride (boiling point: 200 ° C.), 2-bromo-2
-Nitropropane-1,3-diol (pronopol,
Melting point 132 ° C.), 2,4,4′-trichloro-2′-hydroxydiphenyl ether (boiling point 200 ° C.), p-hydroxybenzoic acid ester (boiling point 200 ° C.), and the like, but are not limited thereto. These fungicides may be used alone or in combination of two or more. The content of these bactericides is in the range of 0.001 to 1% by weight in a solution comprising water and a water-soluble solvent. still,
It is also possible to prepare a highly concentrated product (usually 20 to 30%) of a bactericide, dilute it with water at the time of use, and adjust it to the above range before use.

Next, the water-soluble solvent used in the present invention is:
It is a liquid at ordinary temperature and has a boiling point of 120 ° C. or higher, and particularly preferably a non-volatile one. It is important that the water-soluble solvent is capable of dissolving the germicide and has no reactivity with the germicide. For example, among the glycols that are water-soluble solvents, propylene glycol, polyethylene glycol, polypropylene glycol, and the like, which are commonly used, dissolve the above-mentioned bactericide therein. Germicidal power cannot be exhibited, which is not preferable. Among the amine-based water-soluble solvents, strongly alkaline and reactive solvents such as monoethanolamine, diethanolamine, and triethanolamine, and those having a strong amine odor are also not preferred. Further, the water-soluble solvent needs to have low skin irritation and low toxicity, and it is preferable to use those which are currently used as pharmaceuticals, cosmetics or food additives. As such a water-soluble solvent, for example, those listed in Table 1 below can be used.

[0010]

[Table 1]

In the present invention, the disinfectant is prepared by dissolving a bactericide in an aqueous solution in which 0.5 to 80% by weight of the above water-soluble solvent is dissolved in water.
The water-soluble solvent in which the disinfectant is dissolved forms a film and covers the surface of the skin or object to be disinfected, thereby maintaining the disinfecting power. At this time, if the content of the water-soluble solvent in the disinfectant is too large, a sticky feeling remains for a long time, and if the content is too small, coating is not sufficient. Since these water-soluble solvents have lipophilicity, they have excellent affinity with the skin, have a large hand-roughness-preventing power, have very low degreasing power, and have a high boiling point. The sterilizing power is maintained by the film in which is dissolved.

The disinfectant of the present invention can be produced by dissolving a bactericide in the above water-soluble solvent and then dissolving the same in water such as purified water. Alternatively, it can be produced by dissolving a water-soluble solvent in water in advance and dissolving a bactericide in this aqueous solution. Further, this disinfectant can be used as a cream by using an oil agent other than the above-mentioned water-soluble solvent. In addition, additives such as fragrances and preservatives may be added, and a small amount of alcohol may be further added.
Hereafter, it is more preferably 5% or less.

The disinfectant of the present invention can be used in liquid form for hand disinfection, environmental disinfection, or the like, or may be used by filling it in a spray can or sprayer and spraying it.

[0014]

EXAMPLES (Experiment 1: Degreasing test of water-soluble solvent) Capacity 70
Approximately 5 g of tallow is applied to the side wall of a cc glass container using a spatula, and 50 cc of various solvents shown in Table 2 are poured into the container, and the tallow is immersed in the solvent and allowed to stand in a constant temperature chamber at 25 ° C. 24 hours later, the change was visually confirmed. Table 2 shows the results.

[0015]

[Table 2]

From the results in Table 2, it can be seen that the water-soluble solvent used in the disinfectant of the present invention has a lower dissolving power for beef tallow, that is, less degreasing power, and has a rough hand and a rough skin, as compared with ethanol, which is frequently used in conventional disinfectants. It is clear that there are few.

(Experiment 2: Fungicide Solubility Test) The solubility of the fungicide in a water-soluble solvent was examined. Tables 3 to 9 show the results.
Shown in

[0018]

[Table 3]

[0019]

[Table 4]

[0020]

[Table 5]

[0021]

[Table 6]

[0022]

[Table 7]

[0023]

[Table 8]

[0024]

[Table 9]

Next, the present invention will be described specifically with reference to examples, but these examples do not limit the present invention at all.

Example 1 A disinfectant was prepared by dissolving 0.005% by weight of benzalkonium chloride in an aqueous solution containing 50% by weight of various water-soluble solvents shown in Table 10. These disinfectants were tested for their bactericidal effect against bacteria. In the test, the viability of the bacteria was determined over time after the bacterial solution of Escherichia coli was added to the disinfectant. Table 10 shows the results. In the table,
"+" Indicates that the bacteria were not killed, and "-" indicates that the bacteria were killed.

The test method is as follows. (1) Test strain Escherichia coli: Escherichia coli ATCC25922 (2) Preparation of test bacterial solution The test bacterial cells were cultured on a standard agar medium (Nippon Pharmaceutical) at 35 ° C 18 to 2
After culturing for 4 hours, the cells were suspended in a phosphate buffer, and prepared so that the number of cells was about 10 ⁸ / ml, and used as a test bacterial solution. (3) Post-culture medium and culture conditions Post-culture medium: SCDLP medium (Nippon Pharmaceutical) Culture conditions: 35 ° C, 2 days (4) Test operation 1 ml of test bacterial solution is added to 10 ml of sample, and after mixing, it acts at 20 ° C for a certain time. I let it. 30 seconds, 60 seconds, and 6 hours after the start of the action, one loopful of loop was inoculated from the test tube into the post-culture medium, and after cultivation, the presence or absence of the growth of the test bacterium was observed to determine the viability of the bacterium. In addition, the same test was performed on sterilized water as a control.

[0028]

[Table 10]

Examples 2 to 7 The same aqueous solution containing 50% by weight of various water-soluble solvents as in Example 1 was added to chlorhexidine gluconate, benzethonium chloride, acrinol,
Benzoic acid, alkyldiaminoethylglycine hydrochloride or pronopol (2-bromo-2-nitropropane-1,3
-Diol) was dissolved at 0.01% by weight to prepare a disinfectant. For these disinfectants, a bactericidal effect test on bacteria was performed in the same manner as in Example 1. The results are shown in Tables 11 to 1.
6 is shown.

[0030]

[Table 11]

[0031]

[Table 12]

[0032]

[Table 13]

[0033]

[Table 14]

[0034]

[Table 15]

[0035]

[Table 16]

[0036]

As described above, the disinfectant of the present invention is disinfected in a water-soluble solvent having a low degreasing power and a high boiling point, instead of a volatile ethanol having a high degreasing power and a low boiling point unlike the conventional disinfectant. Since the agent is dissolved, even when used for disinfecting fingers, skin, etc., there is no risk of roughening of the hands and rough skin, and the sterilizing power is excellent. This disinfectant is used as a disinfectant for fingers, skin, and general environment.
Furthermore, it can also be used for disinfecting cooling water for machining and preventing spoilage.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A01N 37/44 A01N 37/44 4H011 43/42 43/42 47/44 47/44 A61K 31/047 A61K 31 / 047 31/085 31/085 31/14 31/14 31/155 31/155 31/192 31/192 31/198 31/198 31/473 31/473 45/08 45/08 47/10 47/10 47/14 47/14 47/18 47/18 A61L 2/18 A61L 2/18 A61P 31/02 A61P 31/02 F term (reference) 4C058 AA20 AA28 AA29 BB07 JJ06 4C076 AA12 BB31 CC18 DD37E DD45E DD50E FF12 4C084 AA17 NA ZA901 ZA902 4C086 AA01 AA02 BC27 MA02 MA05 NA06 ZA90 4C206 AA01 AA02 CA28 DA19 DB17 DB41 EA01 FA41 FA42 FA51 HA31 MA05 MA37 MA83 NA06 ZA90 4H011 AA02 BA01 BA06 BB03 BB04 BB06 BB09 BB11 BC03 BC04 BC06

Claims (4)

[Claims] 1. A disinfectant having a boiling point of 120 ° C. or more is dissolved in an aqueous solution in which a water-soluble solvent having a boiling point of 120 ° C. or more and being liquid at room temperature is dissolved in an amount of 0.5 to 80% by weight. Disinfectant. 2. The method according to claim 1, wherein the disinfectant is benzalkonium chloride, chlorhexidine gluconate, benzethonium chloride, acrinol, benzoic acid, alkyldiaminoethylglycine hydrochloride, 2-bromo-2-nitropropane-1,3-diol, 2,4. The disinfectant according to claim 1, wherein the disinfectant is at least one selected from the group consisting of 4,4'-trichloro-2'-hydroxydiphenyl ether and paraoxybenzoate. 3. The water-soluble solvent is isoprene glycol, hexylene glycol, triethylene glycol,
Ethyl lactate, methyl lactate, 1,3-butanediol,
The at least one member selected from the group consisting of 1,4-butanediol, N-methylethanolamine, N-aminoethylethanolamine, N-methyldiethanolamine and N-propanolamine. Disinfectant. 4. The disinfectant according to claim 1, which does not substantially contain alcohol.