JP2002145787A - External preparation - Google Patents
External preparationInfo
- Publication number
- JP2002145787A JP2002145787A JP2000335403A JP2000335403A JP2002145787A JP 2002145787 A JP2002145787 A JP 2002145787A JP 2000335403 A JP2000335403 A JP 2000335403A JP 2000335403 A JP2000335403 A JP 2000335403A JP 2002145787 A JP2002145787 A JP 2002145787A
- Authority
- JP
- Japan
- Prior art keywords
- water
- primary
- external preparation
- acidic water
- alkaline water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、刺激性がなくかつ
優れた殺菌作用や使用感を有する外用剤を提供すること
にある。[0001] The present invention is to provide an external preparation having no irritancy and excellent bactericidal action and feeling of use.
【０００２】[0002]
【従来の技術】食塩水を電気分解することにより得られ
る酸性水には優れた殺菌効果や脱臭効果、アルカリ水に
は抗酸化作用や活性酸素消去作用など様々な機能がある
ことが知られている。この酸性水やアルカリ水は、陰極
と陽極が取り付けられた電解槽の間にイオン交換膜から
なる隔壁を設置した中で、食塩水を電気分解すること
で、カソード室に生成するアルカリ水と、アノード室に
生成する酸性水を応用したものであった。これらの電解
水を化粧料や入浴剤などの外用剤に応用するべく検討さ
れているが（特開平７−２７７９９４号公報、特開平９
-１２４４３１号公報、特開平９−３１５９２５号公
報）、酸性水の水素イオン濃度（ｐＨ値）は約２．５、
アルカリ水のｐＨは約１１であるために、皮膚に塗布し
た場合に刺激性を有していることが課題とされていた。2. Description of the Related Art It is known that acidic water obtained by electrolyzing salt water has various functions such as excellent sterilizing effect and deodorizing effect, and alkaline water has various functions such as antioxidant effect and active oxygen scavenging effect. I have. The acidic water and the alkaline water are alkaline water generated in a cathode chamber by electrolyzing a saline solution in a partition wall made of an ion exchange membrane installed between an electrolytic cell having a cathode and an anode attached thereto, This was an application of acidic water generated in the anode compartment. Studies have been made to apply these electrolyzed waters to external preparations such as cosmetics and bathing agents (Japanese Patent Application Laid-Open Nos. Hei 7-277994 and Hei 9).
-124431, JP-A-9-315925), the hydrogen ion concentration (pH value) of acidic water is about 2.5,
Since the pH of the alkaline water is about 11, it has been considered that the alkaline water has irritation when applied to the skin.
【０００３】また、化粧料や入浴剤などの外用剤に海洋
深層水や海洋深層水を逆浸透膜や電気透析などの脱塩処
理したものの応用が検討されているが（特開平１０−１
８２３４６号公報、特開平１１−１２１５４号公報、特
開２０００−１５９６５５号公報）、前者は塩化ナトリ
ウムを多量に含んでいるために使用感を損なうことや、
後者では特徴成分であるミネラル成分も除去されてしま
うために海洋深層水の有用性を十分に応用することが困
難であった。更に海洋深層水もしくはその希釈水溶液を
電気分解して得たアルカリ水の健康飲料への応用につい
ても検討が為されている（特開２０００−２３６４６号
公報）。[0003] Further, application of external preparations such as cosmetics and bath preparations, which are obtained by subjecting deep sea water or deep sea water to desalting treatment such as reverse osmosis membrane or electrodialysis, has been studied (Japanese Patent Laid-Open No. 10-1).
No. 82346, Japanese Patent Application Laid-Open No. H11-12154, Japanese Patent Application Laid-Open No. 2000-159655), the former impairs the feeling of use because it contains a large amount of sodium chloride,
In the latter case, it is difficult to fully utilize the usefulness of deep ocean water because the mineral component, which is a characteristic component, is also removed. Furthermore, application of alkaline water obtained by electrolyzing deep sea water or a diluted aqueous solution thereof to health drinks has been studied (Japanese Patent Application Laid-Open No. 2000-23646).
【０００４】[0004]
【発明が解決しようとする課題】本発明は、刺激性がな
くかつ優れた殺菌作用や使用感を有する外用剤を提供す
ることにある。SUMMARY OF THE INVENTION An object of the present invention is to provide an external preparation having no irritating properties and excellent bactericidal action and feeling upon use.
【０００５】[0005]
【課題を解決するための手段】本発明者等は、上記課題
を解決すべく鋭意検討した結果、二次電解水を利用する
ことによって、上記課題を解決することができた。すな
わち、本発明は、海洋深層水等の塩化ナトリウムが溶解
している水溶液を電気分解し、陰極側からは一次アルカ
リ水を、陽極側からは一次酸性水を各々生成し、上記一
次アルカリ水と一次酸性水を密閉状態で混合し、この混
合液を再度電気分解することで得られる二次アルカリ水
及び／又は二次酸性水を配合することを特徴とする外用
剤にある。Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors have been able to solve the above problems by using secondary electrolyzed water. That is, the present invention electrolyzes an aqueous solution in which sodium chloride is dissolved, such as deep sea water, and produces primary alkaline water from the cathode side and primary acidic water from the anode side, respectively, An external preparation characterized by blending a secondary alkaline water and / or a secondary acidic water obtained by mixing primary acidic water in a closed state and electrolyzing the mixture again.
【０００６】[0006]
【発明の実施の形態】本発明によれば、海洋深層水等の
塩化ナトリウムが溶解している水溶液を電気分解し、陰
極側からは一次アルカリ水を、陽極側からは一次酸性水
を各々生成し、上記一次アルカリ水と一次酸性水を密閉
状態で混合し、この混合液を再度電気分解することで得
られる二次アルカリ水及び／又は二次酸性水を配合する
ことにより刺激性がなくかつ優れた殺菌作用や使用感を
有する外用剤を得ることが可能となるなどその効果の特
性は著しい。電気分解する塩化ナトリウムを溶解してい
る水溶液としては、塩化ナトリウム水溶液、海水、人工
海水や海洋深層水を挙げることができるが、特に微量ミ
ネラルを豊富に含む海洋深層水もしくはその希釈水が好
ましい。ここで言う海洋深層水とは深度２００ｍ以上の
深海から取水される海水である。According to the present invention, an aqueous solution in which sodium chloride is dissolved, such as deep sea water, is electrolyzed to produce primary alkaline water from the cathode side and primary acid water from the anode side. Then, the primary alkaline water and the primary acidic water are mixed in a closed state, and the mixture is mixed with a secondary alkaline water and / or a secondary acidic water obtained by electrolyzing the mixture again to be non-irritating, and The properties of the effect are remarkable, for example, it is possible to obtain an external preparation having an excellent bactericidal action and a feeling of use. Examples of the aqueous solution in which sodium chloride to be electrolyzed is dissolved include an aqueous sodium chloride solution, seawater, artificial seawater, and deep ocean water. Particularly, deep ocean water rich in trace minerals or dilution water thereof is preferable. The deep ocean water referred to here is seawater taken from the deep sea at a depth of 200 m or more.
【０００７】上記電気分解水を得るための装置として
は、例えば、陽極と陰極が設けられ、好ましくは該陽極
と陰極の間がイオン交換膜等の隔膜で仕切られているア
ノード室とカソード室からなる一次電解槽と、該一次電
解槽によって得られた一次アルカリ水と一次酸性水とを
密閉状態で混合する混合部を備えたマニホールドと、上
記一次電解槽と同様な構造の二次電解槽からなる装置が
使用される。[0007] As an apparatus for obtaining the electrolyzed water, for example, an anode and a cathode are provided, and preferably, an anode chamber and a cathode chamber are separated from each other by a membrane such as an ion exchange membrane. A primary electrolytic cell, and a manifold having a mixing section for mixing the primary alkaline water and the primary acidic water obtained by the primary electrolytic tank in a sealed state, and a secondary electrolytic tank having a structure similar to that of the primary electrolytic tank. Is used.
【０００８】本発明の海洋深層水等の塩化ナトリウムが
溶解している水溶液を電気分解し、陰極側からは一次ア
ルカリ水を、陽極側からは一次酸性水を各々生成し、上
記一次アルカリ水と一次酸性水を密閉状態で混合し、こ
の混合液を再度電気分解することで得られる二次アルカ
リ水、二次酸性水、または二次アルカリ水と二次酸性水
の混合水を配合することを特徴とする本発明の外用剤に
は、必要に応じ、その効果を損なわない範囲で一般に外
用剤の組成物として用いられる各種成分、すなわち油
分、界面活性剤、保湿剤、増粘剤、防腐剤、酸化防止
剤、紫外線吸収剤、香料、色素などを組み合わせて配合
することができる。また二次アルカリ水は外用剤以外に
飲料水として用いることもできる。The aqueous solution of the present invention in which sodium chloride is dissolved, such as deep sea water, is electrolyzed to produce primary alkaline water from the cathode side and primary acidic water from the anode side. Mix the primary acidic water in a closed state, and mix secondary alkaline water, secondary acidic water, or mixed water of secondary alkaline water and secondary acidic water obtained by electrolyzing this mixture again. The external preparation of the present invention is characterized by, if necessary, various components generally used as a composition of the external preparation within a range not impairing its effects, that is, oils, surfactants, humectants, thickeners, preservatives , An antioxidant, an ultraviolet absorber, a fragrance, a dye, and the like. The secondary alkaline water can be used as drinking water in addition to the external preparation.
【０００９】また、上記二次アルカリ水及び／又は二次
酸性水の本発明の外用剤への配合量は目的、対象とする
ものにより千差万別であり一概に規定できるものではな
いが、一般的には１．０〜１００質量％が好ましい。本
発明の外用剤としては人体等の皮膚、頭皮、頭髪などに
適用するものでありスキンローション、乳液、クリー
ム、洗鼻剤、入浴剤などの化粧料、外用医薬部外品、外
用医薬品などであり、二次酸性水を配合した外用剤は殺
菌効果や消臭効果などが得られ、二次アルカリ水を配合
した外用剤では製品の安定性の向上などを期待すること
ができる。The amount of the secondary alkaline water and / or secondary acidic water to be added to the external preparation of the present invention varies widely depending on the purpose and target, and cannot be specified unconditionally. Generally, 1.0 to 100% by mass is preferable. The external preparation of the present invention is applied to the skin of the human body, etc., scalp, hair and the like. Yes, an external preparation containing secondary acidic water can provide a bactericidal effect and a deodorizing effect, and an external preparation containing secondary alkaline water can be expected to improve product stability.
【００１０】[0010]
【実施例】以下、実施例を挙げて本発明をさらに詳細に
説明するが、本発明は、これらによって限定されるもの
ではない。また、実施例に示す％は、質量％を意味す
る。The present invention will be described in more detail with reference to the following Examples, which should not be construed as limiting the invention. Further,% shown in Examples means mass%.
【００１１】製造方法１（海洋深層水二次アルカリ水及
び二次酸性水の製造方法） 富山湾沖にて取水した海洋深層水を図１に示した様な、
海洋深層水を定量供給して一次電気分解する、カソード
室（６）とアノード室（７）をイオン交換樹脂の隔膜
（５）で分離した一次電解槽（１）と、一次アルカリ水
と二次酸性水を密閉状態で混合するマニホールド（８）
と、一次アルカリ水と一次酸性水の混合水を供給して二
次電気分解する、同じくカソード室（６）とアノード室
（７）をイオン交換樹脂の隔膜（５）で分離した二次電
解槽（２）を互いを順次に連通管で連結した製造装置を
用いて、一次及び二次電気分解処理を行った。また、電
気分解条件は電解電圧２．８Ｖ、電解電流ＤＣ７Ａで行
った。その時に得られた各二次電解水のｐＨ値、塩素濃
度、過酸化水素濃度及び酸化還元電位を表１に示した。
塩素濃度はクロ−ルマスタ−（コニカ塩素濃度測定キッ
ト）、過酸化水素濃度は 過酸化水素試験紙（チェクル
・ＫＳ，栗田工業株発売元）、そして酸化還元電位：
東亜電波、ｐＨメ−タ−（ＨＭ−２０Ｊ）、電極：ＰＳ
−５１ １１Ｃ使用を用いて測定した。Production method 1 (Production method of secondary alkaline water and secondary acid water in deep ocean water) Deep ocean water taken off the coast of Toyama Bay is shown in FIG.
A primary electrolyzer (1) in which a cathode chamber (6) and an anode chamber (7) are separated by an ion exchange resin membrane (5), and a primary electrolyzer is used for primary electrolysis by supplying a constant amount of deep ocean water; Manifold for mixing acidic water in a sealed state (8)
And a secondary electrolyzer in which mixed water of primary alkaline water and primary acidic water is supplied to perform secondary electrolysis. Similarly, a cathode chamber (6) and an anode chamber (7) are separated by an ion exchange resin membrane (5). Primary and secondary electrolysis treatments were performed using a manufacturing apparatus in which (2) was sequentially connected to each other by a communication pipe. The electrolysis was performed at an electrolysis voltage of 2.8 V and an electrolysis current of DC 7 A. Table 1 shows the pH value, chlorine concentration, hydrogen peroxide concentration, and oxidation-reduction potential of each secondary electrolyzed water obtained at that time.
Chlorine concentration is chlorine master (Konica chlorine concentration measurement kit), hydrogen peroxide concentration is hydrogen peroxide test paper (Chekul KS, Kurita Kogyo Co., Ltd.), and redox potential:
Toa radio wave, pH meter (HM-20J), electrode: PS
Measured using -51 11C.
【００１２】 ［表１］（得られた各電解水の物性値） ｐＨ値 塩素濃度 過酸化水素濃度 酸化還元電位 ------------------------------------------------------------------ 一次アルカリ水 １１．１ − − −１０００ｍＶ 一次酸性水 ２．８ − − １１６０ｍＶ 二次アルカリ水 １０．１ １００ｐｐｍ ２５ｐｐｍ ６９９ｍＶ 二次酸性水 ６．３ ２００ｐｐｍ ５０ｐｐｍ １００２ｍＶ 混合水（二次アルカリ水：二次酸性水＝１：１） ８．３ １５０ｐｐｍ ５０ｐｐｍ ８０１ｍＶ[Table 1] (physical property values of each obtained electrolyzed water) pH value Chlorine concentration Hydrogen peroxide concentration Redox potential --------------------- --------------------------------------------- Primary alkaline water 11. 1---1000 mV Primary acidic water 2.8--1160 mV Secondary alkaline water 10.1 100 ppm 25 ppm 699 mV Secondary acidic water 6.3 200 ppm 50 ppm 1002 mV Mixed water (secondary alkaline water: secondary acidic water = 1: 1) ) 8.3 150 ppm 50 ppm 801 mV
【００１３】製造方法２（海水二次アルカリ水及び二次
酸性水の製造方法） 製造方法１で用いた海洋深層水を富山湾にて取水した海
水を変えた以外は、製造方法１の方法に従い、本発明で
用いる二次アルカリ水、二次酸性水及びその混合水（二
次アルカリ水：二次酸性水＝１：１）を調製した。その
時に得られた各二次電解水のｐＨ値は、二次アルカリ水
は１０．７、二次酸性水は５．８及び混合水は８．３で
あった。Production method 2 (Method of producing secondary alkaline water and secondary acid water in seawater) The method of production method 1 is followed except that the deep sea water used in production method 1 is changed to seawater taken in Toyama Bay. A secondary alkaline water, a secondary acidic water and a mixed water thereof (secondary alkaline water: secondary acidic water = 1: 1) used in the present invention were prepared. The pH value of each secondary electrolyzed water obtained at that time was 10.7 for secondary alkaline water, 5.8 for secondary acidic water, and 8.3 for mixed water.
【００１４】次に本発明の組成物の微生物に対する殺菌
性の試験方法を以下に示した。 ［微生物に対する殺菌性試験法］滅菌ガラス試験管（１
８Φ×１６５ｍｍ）に試験サンプル１０ｍｌと滅菌水に
よって１００倍に希釈した供試菌培養液０．１ｍｌ（菌
数 １〜２×１０10）を入れ、３、１５、３０分後の生
存菌数を測定することでサンプルの微生物に対する殺菌
活性を評価した。菌数の測定はＳＣＤ寒天培地を用い、
３２℃において７２時間培養した後にコロニー数を測定
することで実施した。また、供試菌としてStaphylococc
us aureus、 Escherichia coli、 Pseudomonas ae
ruginosa及びBacillus subtilisを用いた。Next, the method for testing the bactericidal activity of the composition of the present invention on microorganisms is shown below. [Test method for bactericidal property against microorganisms] Sterilized glass test tube (1
8Φ × 165 mm), put 10 ml of the test sample and 0.1 ml of the test bacterial culture diluted 100 times with sterile water (the number of bacteria: 1 to 2 × 10 10 ). By measuring, the bactericidal activity of the sample against microorganisms was evaluated. For measurement of the number of bacteria, use SCD agar medium,
After culturing at 32 ° C. for 72 hours, the number of colonies was measured. In addition, Staphylococc
us aureus, Escherichia coli, Pseudomonas ae
ruginosa and Bacillus subtilis were used.
【００１５】実施例１〜３ 製造方法２で得た各二次電解水を精製水にて２倍量に希
釈した後、３質量％のグリセリンと０．２質量％のクエ
ン酸を加え、本発明の外用剤を調製した（表２）。各サ
ンプルの殺菌活性を微生物に対する殺菌性試験法を用い
て検討した結果、表３に示すように本発明で得られた組
成物は優れた抗菌活性を有していることが確認された。Examples 1 to 3 Each of the secondary electrolyzed waters obtained in Production Method 2 was diluted to twice the volume with purified water, and then 3% by weight of glycerin and 0.2% by weight of citric acid were added. An external preparation of the invention was prepared (Table 2). As a result of examining the bactericidal activity of each sample using a bactericidal test method for microorganisms, as shown in Table 3, it was confirmed that the composition obtained by the present invention had excellent antibacterial activity.
【００１６】 ［表２］ 実施例１ 実施例２ 実施例３ ------------------------------------------------------- 二次酸性水 ５０．０ − ２５．０ 二次アルカリ水 − ５０．０ ２５．０ グリセリン ３．０ ３．０ ３．０ クエン酸 ０．２ ０．２ ０．２ 精製水 残余 残余 残余[Table 2] Example 1 Example 2 Example 3 --------------------- Secondary acidic water 50.0-25.0 Secondary alkaline water-50.0 25.0 Glycerin 3.0 3.0 3.0 Citric acid 0.2 0.2 0.2 Purified water Residue Residue Residue
【００１７】 ［表３］ サンプル 菌種 ３分後 １５分後 ３０分後 ------------------------------------------------------------------ 実施例１ Ｓ．ａｕｒｅｕｓ ＜１０ １０ １０ Ｅ．ｃｏｌｉ ＜１０ １０ １０ Ｐ．ａｅｒｕｇｉｎｏｓａ ＜１０ １０ １０ Ｂ．ｓｕｂｔｉｌｉｓ ＜１０ １０ １０ 実施例２ Ｓ．ａｕｒｅｕｓ ＜１０ １０ １０ Ｅ．ｃｏｌｉ ＜１０ １０ １０ Ｐ．ａｅｒｕｇｉｎｏｓａ ＜１０ １０ １０ Ｂ．ｓｕｂｔｉｌｉｓ ＜１０ １０ １０ 実施例３ Ｓ．ａｕｒｅｕｓ ＜１０ １０ １０ Ｅ．ｃｏｌｉ ＜１０ １０ １０ Ｐ．ａｅｒｕｇｉｎｏｓａ ＜１０ １０ １０ Ｂ．ｓｕｂｔｉｌｉｓ ＜１０ １０ １０[Table 3] Sample bacterial species 3 minutes 15 minutes 30 minutes ------------------------------- ----------------------------------- Example 1 aureus <10 10 10 E. coli <10 10 10 P.E. aeruginosa <10 10 10 B. subtilis <10 10 10 Example 2 aureus <10 10 10 E. coli <10 10 10 P.E. aeruginosa <10 10 10 B. subtilis <10 10 10 Example 3 aureus <10 10 10 E. coli <10 10 10 P.E. aeruginosa <10 10 10 B. subtilis <10 10 10
【００１８】実施例４及び５、比較例１〜３（ローショ
ン） 下記表４の組成からなる外用剤ローションを通常の製造
方法にて製造し、試料とした。Examples 4 and 5, Comparative Examples 1 to 3 (Lotions) External preparation lotions having the compositions shown in Table 4 below were produced by a usual production method and used as samples.
【００１９】 ［表４］ 配合成分 実施例４ 実施例５ 比較例１ 比較例２ 比較例３ ------------------------------------------------------------------ グリセリン ３．０ ３．０ ３．０ ３．０ ３．０ 乳酸 ０．５ ０．５ ０．５ ０．５ ０．５ メチルパラベン ０．１ ０．１ ０．１ ０．１ ０．１ 製造方法１の二次酸性水 ３０．０ − − − − 製造方法１の二次アルカリ水 − ３０．０ − − − 製造方法１の一次酸性水 − − ３０．０ − − 製造方法１の一次アルカリ水 − − − ３０．０ − 富山湾海洋深層水 − − − − ３０．０ 精製水 残余 残余 残余 残余 残余[Table 4] Compounding ingredients Example 4 Example 5 Comparative Example 1 Comparative Example 2 Comparative Example 3 -------------------------- ---------------------------------------- Glycerin 3.0 3.0 3.0 3.0 3.0 Lactic acid 0.5 0.5 0.5 0.5 0.5 0.5 Methyl paraben 0.1 0.1 0.1 0.1 0.1 Secondary acid water of production method 1 30.0 − ---Secondary alkaline water of production method 1-30.0---Primary acidic water of production method 1--30.0--Primary alkaline water of production method 1---30.0-Deep sea of Toyama Bay Water − − − − 30.0 Purified water Residue Residue Residue Residue Residue
【００２０】パネラー３名の頬に試料０．４ｇを塗布
し、その時の刺激感及び使用感を下記官能評価基準によ
り判定した。 ［表５］ 刺激感 使用感 判定 評価 判定 評価 ----------------------------------------------------------------- 全く刺激感を感じなかった ○ 肌なじみが良い ○ やや刺激感を感じた △ 肌なじみがやや良い △ 刺激感を感じた × 肌なじみが悪い ×A sample of 0.4 g was applied to the cheeks of three panelists, and the feeling of irritation and feeling of use at that time was determined according to the following sensory evaluation criteria. [Table 5] Irritation Feeling Usability Judgment Evaluation Judgment Evaluation -------------------------------------- --------------------------- I did not feel any irritation at all ○ Good skin familiarity ○ Somewhat irritating feeling △ Skin familiarity Somewhat good △ Irritation felt × Skin familiarity poor ×
【００２１】実施例４及び５及び比較例１〜３の官能評
価結果を表６に示す。Table 6 shows the sensory evaluation results of Examples 4 and 5 and Comparative Examples 1 to 3.
【００２２】 ［表６］ パネラー１ パネラー２ パネラー３ 刺激感 使用感 刺激感 使用感 刺激感 使用感 -------------------------------------------------------------- 実施例４ ○ ○ ○ ○ ○ ○ 実施例５ ○ ○ ○ ○ ○ ○ 比較例１ × △ × × × △ 比較例２ × ○ × △ × ○ 比較例３ ○ × ○ × ○ ×[Table 6] Paneler 1 Paneler 2 Paneler 3 Irritation feeling Feeling feeling Feeling feeling Feeling feeling Feeling ------------------------- ------------------------------------- Example 4 ○ ○ ○ ○ ○ ○ Example 5 ○ ○ ○ ○ ○ ○ Comparative Example 1 × △ × × × △ Comparative Example 2 × ○ × △ × ○ Comparative Example 3 ○ × ○ × ○ ×
【００２３】表６に示す如く、本発明の実施例４及び５
の外用剤は、表５に示す項目についての官能評価により
刺激性がなく優れた使用感を有していることが明らかと
なった。As shown in Table 6, Examples 4 and 5 of the present invention
According to the sensory evaluation of the items shown in Table 5, it was found that the external preparation had no irritation and had an excellent feeling upon use.
【００２４】[0024]
【発明の効果】海洋深層水等の塩化ナトリウムが溶解し
ている水溶液を電気分解し、陰極側からは一次アルカリ
水を、陽極側からは一次酸性水を各々生成し、上記一次
アルカリ水と一次酸性水を密閉状態で混合し、この混合
液を再度電気分解することで得られる二次アルカリ水及
び／又は二次酸性水を配合することにより刺激性がなく
かつ優れた殺菌作用や使用感を有する外用剤を得ること
ができる。According to the present invention, an aqueous solution in which sodium chloride is dissolved, such as deep sea water, is electrolyzed, and primary alkaline water is produced from the cathode side and primary acidic water is produced from the anode side. Non-irritating and excellent germicidal action and usability can be obtained by mixing acidic water in a sealed state and blending secondary alkaline water and / or secondary acidic water obtained by electrolyzing this mixture again. Can be obtained.
【図１】本発明の実施例で用いた電解水製造装置を説明
する概略図である。FIG. 1 is a schematic diagram illustrating an electrolyzed water producing apparatus used in an embodiment of the present invention.
１ 一次電解槽 ２ 二次電解槽 ３ 陰極板 ４ 陽極板 ５ 隔膜 ６ カソード室 ７ アノード室 ８ マニホールド DESCRIPTION OF SYMBOLS 1 Primary electrolyzer 2 Secondary electrolyzer 3 Cathode plate 4 Anode plate 5 Diaphragm 6 Cathode room 7 Anode room 8 Manifold
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ６１Ｋ 35/02 Ａ６１Ｋ 35/02 Ａ６１Ｐ 17/00 Ａ６１Ｐ 17/00 Ｆターム(参考） 4C083 AA021 AB011 AB031 AB051 AC122 AC302 AC482 CC04 DD23 DD27 EE12 4C086 AA01 AA02 HA01 HA02 MA05 MA17 MA63 NA06 NA08 ZA89 ZA90 ZB35 4C087 AA01 AA02 BA01 CA01 MA17 MA63 NA06 NA08 ZA89 ZA90 ZB35 ──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme coat ゛ (Reference) A61K 35/02 A61K 35/02 A61P 17/00 A61P 17/00 F-term (Reference) 4C083 AA021 AB011 AB031 AB051 AC122 AC302 AC482 CC04 DD23 DD27 EE12 4C086 AA01 AA02 HA01 HA02 MA05 MA17 MA63 NA06 NA08 ZA89 ZA90 ZB35 4C087 AA01 AA02 BA01 CA01 MA17 MA63 NA06 NA08 ZA89 ZA90 ZB35
Claims (2)
電気分解し、陰極側からは一次アルカリ水を、陽極側か
らは一次酸性水を各々生成し、上記一次アルカリ水と一
次酸性水を密閉状態で混合し、この混合液を再度電気分
解し得られた二次アルカリ水及び／又は二次酸性水を配
合することを特徴とする外用剤。An aqueous solution in which sodium chloride is dissolved is electrolyzed to produce primary alkaline water from the cathode side and primary acidic water from the anode side, and the primary alkaline water and the primary acidic water are sealed. An external preparation characterized by mixing secondary alkaline water and / or secondary acidic water obtained by electrolysis of this mixed solution again.
液が、海洋深層水及びその希釈水であることを特徴とす
る請求項１記載の外用剤。2. The external preparation according to claim 1, wherein the aqueous solution in which the sodium chloride is dissolved is deep-sea water and dilution water thereof.
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|---|---|---|---|
| JP2000335403A JP2002145787A (en) | 2000-11-02 | 2000-11-02 | External preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000335403A JP2002145787A (en) | 2000-11-02 | 2000-11-02 | External preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002145787A true JP2002145787A (en) | 2002-05-22 |
Family
ID=18811156
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000335403A Pending JP2002145787A (en) | 2000-11-02 | 2000-11-02 | External preparation |
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| Country | Link |
|---|---|
| JP (1) | JP2002145787A (en) |
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|---|---|---|---|---|
| WO2005063265A1 (en) * | 2003-12-26 | 2005-07-14 | Deepseaservice Co., Ltd. | Active oxygen scavenger containing oceanic deep-layer water as active ingredient, dilution of oceanic deep-layer water having active oxygen scavenging capability and beverage having active oxygen scavenging capability |
| JP2007517064A (en) * | 2003-12-30 | 2007-06-28 | オキュラス イノヴェイティヴ サイエンシズ、インコーポレイテッド | Redox potential aqueous solution and method for producing and using the same |
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2000
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005063265A1 (en) * | 2003-12-26 | 2005-07-14 | Deepseaservice Co., Ltd. | Active oxygen scavenger containing oceanic deep-layer water as active ingredient, dilution of oceanic deep-layer water having active oxygen scavenging capability and beverage having active oxygen scavenging capability |
| JP2007517064A (en) * | 2003-12-30 | 2007-06-28 | オキュラス イノヴェイティヴ サイエンシズ、インコーポレイテッド | Redox potential aqueous solution and method for producing and using the same |
| US9642876B2 (en) | 2003-12-30 | 2017-05-09 | Sonoma Pharmaceuticals, Inc. | Method of preventing or treating sinusitis with oxidative reductive potential water solution |
| EP3205358A1 (en) * | 2003-12-30 | 2017-08-16 | Oculus Innovative Sciences, Inc. | Oxidative reductive potential water solution and method of using the same |
| US10016455B2 (en) | 2003-12-30 | 2018-07-10 | Sonoma Pharmaceuticals, Inc. | Method of preventing or treating influenza with oxidative reductive potential water solution |
| US8840873B2 (en) | 2005-03-23 | 2014-09-23 | Oculus Innovative Sciences, Inc. | Method of treating second and third degree burns using oxidative reductive potential water solution |
| JP2009523832A (en) * | 2006-01-20 | 2009-06-25 | オキュラス イノヴェイティヴ サイエンシズ、インコーポレイテッド | Method for treating or preventing peritonitis using redox potential aqueous solution |
| US9782434B2 (en) | 2006-01-20 | 2017-10-10 | Sonoma Pharmaceuticals, Inc. | Methods of treating or preventing inflammation and hypersensitivity with oxidative reductive potential water solution |
| US10342825B2 (en) | 2009-06-15 | 2019-07-09 | Sonoma Pharmaceuticals, Inc. | Solution containing hypochlorous acid and methods of using same |
| JP2021146212A (en) * | 2020-03-13 | 2021-09-27 | 株式会社Ｅプラン | Bacteria eradication agent and container-contained bacteria eradication agent |
| JP7350353B2 (en) | 2020-03-13 | 2023-09-26 | 株式会社Ｅプラン | Disinfectants and disinfectants in containers |
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