JP2002080320A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic which needs viscosity, has an imparted thickening action, improves hair combability, prevents the branching of hair, imparts gloss and moisture to skins, and smoothens the skins, or a cosmetic which does not need the viscosity so much, improves hair combability, prevents the branching of hair, imparts gloss and moisture to skins, and smoothens the skins. SOLUTION: This cosmetic contains one or more compounds selected from a silylated peptide, a peptide alkyl ester and an acylated peptide salt, and one or more polymer selected from acrylamide/neutralized 2-acrylamide-2- methylpropanesulfonic acid cross-linked copolymer, acryloyldimethyltaurine acid sodium salt copolymer and sodium acrylate/acryloyldimethyltaurine acid sodium salt copolymer.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to cosmetics such as shampoos, hair treatment agents, hair creams, hair dyes, hair dyes, moisture gels, skin creams, facial cleansers, foundations and the like. It gives a thickening effect to necessary cosmetics, improves hair combability and prevents hair branching in hair cosmetics, and gives gloss and moisture to skin in skin cosmetics. And cosmetics for smoothing the skin.

[0002]

2. Description of the Related Art Conventionally, polypeptide derivatives have been used for the purpose of sorbing to hair, preventing damage, repairing split ends, alleviating skin irritation, thickening, moisturizing, and the like.

However, there are two main problems in use.
There was one. That is, in cosmetics containing a polypeptide derivative, it is difficult to thicken with a commonly used thickener, and it has been difficult to prepare gel type and high viscosity type cosmetics. In addition, although the polypeptide derivatives have the above-mentioned effects, some stickiness is recognized on the feel in use depending on the amount of the compound or the compounded compound, and there is a problem that the compound cannot be compounded in an amount sufficient to exert its function. Was.

[0004] Therefore, there has been a demand for the development of a cosmetic that can further improve the effects of the polypeptide derivative, such as hair damage prevention and split hair repairing effects.

[0005]

Therefore, the present invention provides
Provide gel type, high viscosity cosmetics blended with polypeptide derivatives that were difficult to prepare with commonly used thickeners. Further, the polypeptide derivatives have further effects such as preventing damage to hair and repairing split ends. It is an object of the present invention to provide a cosmetic composition having improved effects and improved stickiness on the touch surface in use.

[0006]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, a cosmetic containing the following (A) and (B) has been obtained. And found that the present invention was completed.

That is, (A) the following general formula (I)

[0008]

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[In the formula, at least two of R ¹ , R ² and R ³ are hydroxyl groups, the rest are alkyl groups having 1 to 3 carbon atoms, and R ⁴ is a base having an amino group at a terminal of a side chain. R ⁵ represents a residue of a side chain excluding a terminal amino group of a neutral amino acid;
⁴ represents an amino acid side chain other than ^4;
_{2 -, - (CH 2)} 3 -, - (CH 2) 3 OCH 2 CH
_{(OH) CH 2 -, -} (CH 2) 3 S -, - (CH 2)
Represents at least one group selected from the group consisting of ₃ NH— and — (CH ₂ ) ₃ OCOCH ₂ CH ₂ —, m is 0 to 200, n is 0 to 200, and m + n is 1 to 200 (however, , M and n only indicate the number of amino acids,
It does not indicate the order of amino acid sequences)]], a silylated peptide represented by the following general formula (II)

[0010]

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Wherein R ⁶ represents an amino acid side chain, p represents 1 to 200, and R ⁷ represents an unsaturated or saturated linear or branched alkyl group having 1 to 22 carbon atoms. And a peptide alkyl ester represented by the following general formula (III):

[0012]

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(Wherein R ⁸ represents an unsaturated or saturated linear or branched alkyl group having 7 to 21 carbon atoms;
⁹ represents an amino acid side chain, q represents 1 to 200, and M represents an alkali metal such as sodium or potassium, or an organic alkali such as triethanolamine. One or more selected from the group and (B) acrylamide /
One or more selected from neutralized 2-acrylamido-2-methylpropanesulfonic acid cross-linked copolymer, sodium acryloyldimethyltaurate copolymer, and sodium acrylate / sodium acryloyldimethyltaurate copolymer Related to cosmetics. The above general formulas (I), (II) and (II)
M, n, p, and q in I) are all subscripts.

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION In the peptide derivatives of the group consisting of silylated peptides, peptide alkyl esters and salts of acylated peptides, the peptides used as starting materials include amino acids and peptides.

The above amino acids include alanine, glycine, valine, leucine, isoleucine, proline, phenylalanine, tyrosine, serine, threonine, methionine, arginine, histidine, lysine, asparagine, aspartic acid, glutamine, glutamic acid, cystine, cysteine, and cysteine. Acids, tryptophan, hydroxyproline, hydroxylysine, citrulline and the like.

The above peptides include natural peptides,
Hydrolyzed peptides obtained by partially hydrolyzing synthetic peptides and proteins with acids, alkalis or enzymes are mentioned.

Examples of natural peptides include glutathione, pacitracin A, insulin, glucagon, oxytocin, vasopressin and the like, and examples of synthetic peptides include polyglycine, polylysine, polyglutamic acid, polyserine, polyaspartic acid and the like. Can be

Examples of the hydrolyzed peptides include animals (including collagen, including denatured gelatin), keratin, silk fibroin, casein, conchiolin, elastin, egg yolk protein, soy protein, wheat protein, rice, and potato proteins. Derived proteins, yeasts of the genera Saccharomyces, Candida and Endomycopsis, yeast proteins isolated from yeasts called brewer's yeast, sake yeast, proteins extracted from mushrooms, proteins isolated from chlorella, etc. Is a peptide obtained by partially hydrolyzing a protein derived from a microorganism with an acid, an alkali, an enzyme or a combination thereof.In the hydrolyzed peptide, a mixture of peptides composed of the various amino acids is used. Includes those having amino acid dimers of 2 to 200.

The silylated peptide which is one of the peptide derivatives (A) constituting the cosmetic of the present invention has a functional group containing only one silicon atom in the amino group containing the amino group on the amino acid side chain of the peptide. A covalently bonded compound represented by the following general formula (I)

[0020]

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[Wherein at least two of R ¹ , R ² and R ³ are hydroxyl groups, the rest are alkyl groups having 1 to 3 carbon atoms, and R ⁴ is a base having an amino group at a terminal of a side chain. R ⁵ represents a residue of a side chain excluding a terminal amino group of a neutral amino acid;
⁴ represents an amino acid side chain other than ^4;
_{2 -, - (CH 2)} 3 -, - (CH 2) 3 OCH 2 CH
_{(OH) CH 2 -, -} (CH 2) 3 S -, - (CH 2)
Represents at least one group selected from the group consisting of ₃ NH— and — (CH ₂ ) ₃ OCOCH ₂ CH ₂ —, m is 0 to 200, n is 0 to 200, and m + n is 1 to 200 (however, , M and n only indicate the number of amino acids,
It does not indicate the order of the amino acid sequences.)].
No. 24, JP-A-8-67608, and the like can be easily synthesized in an aqueous solution.

In the silylated peptide represented by the formula (I), n and m are from 0 to 200, preferably from 0 to 50, more preferably from 0 to 10, and m + n is from 1 to 200; Preferably it is 2 to 100, more preferably 3 to 50, for the following reason.

That is, when m is larger than the above range, the number of silyl compounds bonded to the amino group in the side chain increases, and the sorption effect of the peptide on hair or skin decreases, and n is larger than the above range. Then, the ratio of the silylated compound to the peptide moiety is reduced, and the effect of the silylated compound cannot be sufficiently exhibited, and m + n
Is larger than the above range, the sorption property as a peptide is reduced as compared with a peptide having a low molecular weight, and the peptide is easily aggregated during storage, and the storage stability as cosmetics is reduced. The above m, n and m + n are theoretically integers. However, when the peptide is a hydrolyzed peptide as described above, since the hydrolyzed peptide is obtained as a mixture of those having different molecular weights, the measured values Is the average value.

Specific examples of the silylated peptide include silylated hydrolyzed silk, silylated hydrolyzed collagen, silylated hydrolyzed keratin, silylated hydrolyzed soy protein, silylated hydrolyzed wheat protein, and the like. These aqueous solutions are Promois W-52SIG, Promois S-700SIG, Promois WS-HSI
G, sold under the name Promois WK-HSIG.

As the alkyl ester of the peptide, the following general formula (II)

[0026]

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(Wherein, R ⁶ represents an amino acid side chain, p represents 1 to 200, and R ⁷ represents an unsaturated or saturated linear or branched alkyl group having 1 to 22 carbon atoms) And specific examples thereof include, for example, methyl ester, ethyl ester, propyl ester, isopropyl ester, lauryl ester, cetyl ester, 2-ethylhexyl ester, 2-hexyldecyl of the above amino acids or polypeptides Examples include esters, stearyl esters, and isostearyl esters.

As the salt of the acylated peptide, for example, the following general formula (III)

[0029]

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Wherein R ⁸ represents an unsaturated or saturated linear or branched alkyl group having 7 to 21 carbon atoms;
⁹ represents an amino acid side chain, q represents 1 to 200, and M represents an alkali metal such as sodium or potassium, or an organic alkali such as triethanolamine.

Examples of the salt of the acylated amino acid or polypeptide include lauric acid-hydrolyzed collagen potassium, lauric acid-hydrolyzed silk sodium,
Lauric acid hydrolyzed keratin potassium, lauric acid hydrolyzed wheat protein sodium, lauric acid hydrolyzed conchiolin, lauric acid hydrolyzed soy protein potassium,
Coconut palm oil hydrolyzed collagen potassium, palm oil fatty acid hydrolyzed silk sodium, palm oil fatty acid hydrolyzed keratin potassium, myristic acid hydrolyzed collagen sodium, myristic acid hydrolyzed silk sodium, myristic acid glutamate potassium, myristic acid hydrolyzed keratin, myristic Potassium polyaspartate,
Palmitic acid hydrolyzed collagen sodium, palmitic acid hydrolyzed silk triethanolamine, stearic acid hydrolyzed collagen potassium, hydrogenated resin acid hydrolyzed collagen potassium, hydrogenated resin acid hydrolyzed silk potassium, hydrogenated resin acid hydrolyzed keratin potassium, etc. Is mentioned.

In the alkyl ester of the peptide represented by the general formula (II) and the salt of the acylated peptide represented by the general formula (III), p and q are 1 to 20 respectively.
It is 0, preferably 2 to 100, and more preferably 3 to 50, for the following reasons.

That is, when each of p and q is larger than the above range, the sorption property as a peptide is reduced as compared with a peptide having a low molecular weight, and the film-forming effect of the peptide is strongly exerted. It may cause stiffness or give a feeling of tightness to the skin with skin cosmetics. In addition, in the case of the alkyl ester of the peptide represented by the general formula (II), compatibility with the organic solvent of the peptide ester And the emulsifying ability and surface-active ability of the acylated peptide of the salt of the acylated peptide represented by the general formula (III) are reduced. Although p and q are also theoretically integers, when the peptide is a hydrolyzed peptide as described above, the hydrolyzed peptide is obtained as a mixture of different molecular weights. Become.

The acrylamide / neutralized 2-acrylamido-2-methylpropanesulfonic acid crosslinked copolymer which is one of the components (B) constituting the present invention is, for example, tetraallyloxyethane, allylsaccharose, allylpentaerythritol or methylene A copolymer crosslinked with a substance containing olefinic polyunsaturation, such as bisacrylamide, partially or completely neutralized with sodium hydroxide, potassium hydroxide, aqueous ammonia or triethanolamine, monoethanolamine, etc. is there.

One of the copolymers of the present invention is prepared by reacting acrylamide with a catalyst such as azobisisobutyronitrile.
-Acrylamido-2-methylpropanesulfonate obtained by copolymerization and precipitation in an alcohol such as tertiary butanol, with preferred copolymers being 10 ^-4 to ^{4 -4} per mole of the mixture of monomers.
It is obtained by copolymerizing 70 to 55 mol% of acrylamide and 30 to 45 mol% of sodium 2-acrylamido-2-methylpropanesulfonate using a crosslinking agent at a concentration of × 10 ⁻⁴ mol%.

The copolymer used in the present invention can also be used as a composition, for example, 35 to 45% by weight of an acrylamide / neutralized 2-acrylamido-2-methylpropanesulfonic acid crosslinked copolymer, 15 to 25% by weight of isoparaffin. A composition comprising 3-8% POE (7) lauryl ether and water. This composition is sold under the name SEPIGEL 305 (Sepigel 305) by Sepik.

The second copolymer used in the present invention is a sodium acryloyldimethyltaurate copolymer, but can also be used as a composition. A composition comprising sodium acryloyldimethyltaurate copolymer, isohexadecane, polysorbate 80 and water was obtained from Sepik Corporation as SIMULGEL 600 (Simulgel 60).
0).

The third copolymer used in the present invention is a sodium acrylate / sodium acryloyldimethyltaurate copolymer, and can be used as a composition. 35-40% of sodium acrylate / sodium acryloyldimethyltaurate copolymer, 20-25% of isohexadecane, 5-10% of polysorbate 80
% And water is Sepulik's SIMULG
It is marketed under the name of EL EG (Shimagel EG).

The above-mentioned cosmetics may contain other components as long as the effects of the present invention are not impaired. Examples of such components include fats and oils, waxes, hydrocarbons and esters. Oily raw materials such as oils and silicone oils, fatty acids, lower alcohols, higher alcohols, polyhydric alcohols, amino acids, polypeptides, sugars, surfactants, polymers, powders, coloring agents, ultraviolet rays Protective agents, vitamins, plant and animal extracts, antioxidants, disinfectants and preservatives,
Examples include anti-inflammatory agents, sequestering agents, fragrances, whitening agents, hair restorers, skin roughness inhibitors, anti-aging agents and the like.

Specific examples of the oily raw materials include, for example, olive oil, macadamia nut oil, camellia oil, medofoam oil,
High oleic sunflower oil, high oleic safflower oil, castor oil, jojoba oil, carnauba wax, candelilla wax, lanolin, rice bran wax, liquid paraffin, isoparaffin, squalane, petrolatum, ceresin, tri-2-
Glycerol ethylhexanoate, glycerol triisostearate, glycerol triisopalmitate, pentaerythritol tetra-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, diisostearyl malate, 2-ethylhexyl palmitate, 2-ethyl Examples include cetyl hexanoate, isostearyl isostearate, dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, and ceramides.

As fatty acids, for example, octanoic acid,
Decanoic acid, lauric acid, myristic acid, palmitic acid,
Stearic acid, behenic acid, oleic acid, isostearic acid, isopalmitic acid, 12-hydroxystearic acid, ricinoleic acid, resin acid, hydrogenated resin acid, abietic acid, rosin, disproportionated rosin, hydrogenated rosin, tetrahydroabietic acid And the like.

The lower and higher alcohols include, for example, ethanol, propyl alcohol, octanol, lauryl alcohol, myristyl alcohol, palmityl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyldodecanol, oleyl alcohol, behenyl alcohol, and butyl alcohol. ,
Kimyl alcohol, cholesterol, phytosterol and the like, and as the polyhydric alcohol, for example, glycerin, diglycerin, propylene glycol, dipropylene glycol, polypropylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, 1,3-butylene glycol Sorbitol, erythritol, maltitol and the like.

The amino acids include, for example, glycine, alanine, aspartic acid, glutamic acid, cystine, proline, tyrosine, arginine, lysine, and the polypeptides include, for example, collagen, keratin, silk fibroin, casein, conchiolin. , Elastin, egg yolk protein, soy protein, wheat protein, rice, peptides derived from microorganisms and other proteins derived from animals and plants, such as proteins of potatoes, by acid, alkali, enzymes or a combination thereof Is mentioned.

Examples of the nonionic surfactant include, for example,
Polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitol tetra fatty acid ester, glycerin fatty acid ester, sorbitan fatty acid Examples include esters, polyglycerin fatty acid esters, sucrose fatty acid ester alkyl polyglycosides, and polyether-modified silicones.

Examples of the anionic surfactant include, for example,
Fatty acid soap, alkane sulfonate, alkyl sulfate, polyoxyethylene alkyl ether sulfate, fatty acid alkanolamide sulfate, fatty acid monoglyceride sulfate, alkyl phosphate, polyoxyethylene alkyl ether phosphate, N-acyl glutamate And acyl N-methyltaurine salts.

Examples of the cationic surfactant include a tetraalkylammonium salt, a fatty acid amidoamine salt, and an alkyl ether ammonium salt. Examples of the amphoteric surfactant include an alkylglycine salt and N-acylaminoethyl-N-. 2-hydroxyethylglycine salt,
Fatty acid amidopropyl betaine, N-alkyl-N, N
-Dimethylammonium-N-propylsulfonate, phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, phosphatidylglycerol, lysolecithin, lecithin and the like. In addition, a surfactant of a polymer type, a natural type, or the like can also be used.

Examples of the polymers include sodium polyacrylate, carboxyvinyl polymer, vinylpyrrolidone polymer, polyvinyl alcohol, polyacrylamide, amino-modified silicone, methyl cellulose,
Ethyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, sodium alginate, sodium hyaluronate, carrageenan, xanthan gum,
Agar, guar gum, quince seed gum, tamarind gum, starch, dextrin, locust bean gum,
Examples include chitosan, cationized cellulose, cationized guar gum, polyethylene glycol and the like.

Examples of the ultraviolet protective agent include 2-ethylhexyl paramethoxycinnamate and 4-t-butyl-4
Methoxybenzoylmethane, paradimethylaminobenzoic acid, homomenthyl salicylate, octyl diparamethoxycinnamate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonate, 2,
4,6-trianilino-p- (carb-2-ethylhexyl-1-oxy) -1,3,5-triazine and the like.

The vitamins include, for example, vitamin A, vitamin C, vitamin E and derivatives thereof, and the plant extracts include, for example, peonies extract, button skin extract and the like.

[0050]

The present invention will be described in more detail with reference to the following Examples and Comparative Examples. Note that the present invention is not limited by these examples. The amounts of each component in the following Examples and Comparative Examples are all based on parts by weight, and when the amount is not a solid content, the solid content concentration is shown in parentheses after the component name.

Example 1 and Comparative Examples 1A to 1D (Hair Styling Gel) A hair styling gel having the composition shown in Table 1 was prepared, and the viscosity of the preparation and the feeling of use when applied to the hair were compared.

[0052]

[Table 1]

The evaluation of each hair styling gel was performed as follows. That is, each of the hair styling gels of Example 1 and Comparative Examples 1A to 1D shown in Table 1 was picked up, evaluated for its viscosity, applied to the hair, and used for smoothness, unity, and moistness of the hair. The sensory evaluation of the feeling was performed. Note that Comparative Example 1B was not evaluated because it was separated. The results of the evaluation are shown in Table 2, and the evaluation criteria are as shown below.

[Evaluation Criteria] Thickening : O: Viscous , no dripping when picked up. Δ: Difficult to droop. X: Dripping.

[0055]

[Table 2]

As shown in Table 2, the hair styling gel of Example 1 in which N- [2-hydroxy-3- (trimethylammonio) propyl] hydrolyzed keratin solution, hydrolyzed silk ethyl solution and Sepigel 305 were blended. Had a high viscosity and a good feel upon use.

Example 2 and Comparative Examples 2A to 2C (Cream for Skin) A cream for skin having the composition shown in Table 3 was prepared, the viscosity of the preparation was increased, and when applied to the skin, smoothness, spreading, and moist feeling were obtained. Was evaluated.

[0058]

[Table 3]

The evaluation of each skin cream was performed as follows. That is, Example 2 and Comparative Example 2A shown in Table 3
~ 2C each skin cream is applied to the back of the hand, the hair styling gel is picked up, the viscosity is evaluated, and then applied to the hair, and the use feeling such as smoothness, spreading, and moist feeling is comprehensively evaluated. did. The evaluation criteria are as shown below, and the results of the evaluation are shown in Table 4.

[Evaluation Criteria] Thickening : O: Viscous , no dripping when picked up. Δ: Difficult to droop. X: Smooth feeling when dripping; O: Very smooth. Δ: Slightly smooth. ×: Not smooth, stretch; ○: Very smooth, △: Slightly stretchable, ×: Poorly stretchy, moist; ○: Extremely soft, △: Slightly moist, ×: Not moist

[0061]

[Table 4]

As shown in Table 4, the skin cream of Example 2 containing the silylated hydrolyzed silk and Sepigel 305 was excellent in use feeling such as thickening, smoothness, spreading and moist feeling.

Example 3 and Comparative Examples 3A to 3C (Treatment Creams) Hair treatment creams having the compositions shown in Table 5 were prepared, and the viscosity of the preparations and the feeling of use when applied to the hair were compared.

[0064]

[Table 5]

Each sample of the treatment cream shown in Table 5 was taken, evaluated for thickening, and then applied to hair.
Smoothness, ease of unity, moist feeling, etc. were evaluated organoleptically. The evaluation criteria were the same as in Example 1, and the results of the evaluation are shown in Table 6.

[0066]

[Table 6]

As shown in Table 6, the treatment cream of Example 3 in which the silylated hydrolyzed soybean protein solution and Sepigel 305 were blended had good use feeling such as thickening, smoothness, unity, and moist feeling. Met.

Example 4 and Comparative Examples 4A to 4C (Hair Conditioner) A hair conditioner having the composition shown in Table 7 was prepared, and the viscosity of the preparation and the feeling of use when applied to the hair were compared.

[0069]

[Table 7]

Each sample of the hair conditioner shown in Table 7 was picked up, evaluated for thickening, then applied to hair, and subjected to sensory evaluation for smoothness, unity, moistness, and the like. The evaluation criteria were the same as in Example 1, and the results of the evaluation are shown in Table 8.

[0071]

[Table 8]

As shown in Table 8, the hair conditioner of Example 4 in which the hydrolyzed silk ethyl solution, the silylated hydrolyzed keratin, and Sepigel 305 were blended, showed a viscosity increase,
The feeling of use such as smoothness, ease of uniting, and moist feeling was good.

Example 5 and Comparative Examples 5A to 5C (Hair Cream) A hair cream having the composition shown in Table 9 was prepared, and the viscosity of the preparation and the feeling of use when applied to the head hair were compared.

[0074]

[Table 9]

Each sample of the hair cream shown in Table 9 was picked up, evaluated for thickening, applied to the hair, and subjected to sensory evaluation for smoothness, unity, moist feeling, and the like.
The evaluation criteria are the same as in Example 1, and the results of the evaluation are shown in Table 10.
Shown in

[0076]

[Table 10]

As shown in Table 10, the hair cream of Example 5 containing the coconut oil fatty acid-hydrolyzed collagen potassium solution and Sepigel 305 was excellent in use feeling such as thickening, smoothness, unity, and moist feeling. I was

Example 6 and Comparative Examples 6A to 6C (Hair Cream) Hair creams having the compositions shown in Table 11 were prepared, and the viscosity of the preparations and the feeling of use when applied to the hair were compared.

[0079]

[Table 11]

Each sample of the hair cream shown in Table 11 was picked up, evaluated for thickening, applied to hair, and subjected to sensory evaluation for smoothness, unity, moist feeling, and the like.
The evaluation criteria are the same as those in Example 1, and the results of the evaluation are shown in Table 12.
Shown in

[0081]

[Table 12]

As shown in Table 12, the hair cream of Example 6 in which lauroyl hydrolyzed silk sodium solution and Sepigel 305 were blended had good feeling of use such as thickening, smoothness, unity, and moist feeling. Was.

Example 7 and Comparative Example 7A (Oxidative hair dye) A first agent of an oxidative hair dye having the composition shown in Table 13 and a second agent of an oxidative hair dye having the composition shown in Table 14 were prepared. 1st agent and 2nd agent are mixed at 1: 1 (weight ratio) and applied to hair,
The adhesion to hair, spreading and dyeing properties were compared and evaluated.

[0084]

[Table 13]

[0085]

[Table 14]

The first and second oxidative hair dyes of Example 7 and Comparative Example 7A were mixed at a weight ratio of 1: 1.
As a result of applying to the hair and evaluating, the oxidative hair dye of Example 7 in which the first agent containing the silylated hydrolyzed silk and Sepigel 305 was mixed with the second agent containing the hydrolyzed silk ethyl solution and Sepigel 305 was obtained. Compared with the oxidative hair dye of Comparative Example 7A, the hair dye was superior in adhesion to hair, spreading, and dyeing properties.

Example 8 and Comparative Example 8A (Acid Hair Dye) Two kinds of acid hair dyes having the compositions shown in Table 15 were prepared, and the evaluation of the adhesion, spreading, and dyeing properties of each of the acid hair dyes on hair was performed. did.

[0088]

[Table 15]

The acidic hair dye of Example 8 in which the coconut oil fatty acid hydrolyzed collagen sodium solution and Sepigel 305 were blended exhibited better adhesion, spreading and dyeing properties to the hair as compared with the acidic hair dye of Comparative Example 8A. Was.

Example 9 and Comparative Example 9A (Moisture Gel) Two types of moisture gels having the compositions shown in Table 16 were prepared, and the prepared thickened moisture gel was evaluated for thickening, spreading, and moist feeling.

[0091]

[Table 16]

When the moisture gels of Example 9 and Comparative Example 9A were applied to the skin, N- [2-hydroxy-3- (coconut oil alkyldimethylammonio) propyl] hydrolyzed silk and lauroyl hydrolyzed silk sodium were applied. The moisture gel of Example 9 in which Sepigel 305 was blended was compared with the moisture gel of Comparative Example 9A.
It was excellent in thickening, and had good feeling on use such as sticking to the skin, spreading, and moist feeling.

Example 10 and Comparative Example 10A (Skin Cream) Two kinds of skin creams having the compositions shown in Table 17 were prepared.
The prepared skin cream was evaluated for its viscosity increase and use feel (smoothness, moist feeling).

[0094]

[Table 17]

When the moisture gels of Example 10 and Comparative Example 10A were applied to the skin, silylated hydrolyzed keratin, N- [2-hydroxy-3- (trimethylammonio) propyl] hydrolyzed collagen and Sepigel 305 were combined. The blended moisture gel of Example 10 was superior to the moisture gel of Comparative Example 10A in terms of viscosity, smoothness, and moist feeling.

Example 11 and Comparative Example 11A (Hand and Body Lotion) Two kinds of hands and body lotions having the compositions shown in Table 18 were prepared, and the prepared hands and body lotions were thickened and used (smoothness and moistness). Feeling) was evaluated.

[0097]

[Table 18]

When the hand and body lotion of Example 11 and Comparative Example 11A were applied to the skin, the hand and body lotion of Example 11 in which silylated hydrolyzed collagen and Sepigel 305 were blended were used as the hand and body lotion of Comparative Example 11A. As compared with, the use feeling such as thickening, smoothness, spreading and moist feeling was excellent.

Example 12 (Hair Dye) A hair dye having the following composition was prepared and evaluated for sticking, spreading and dyeing properties when applied to hair. The amounts are based on parts by weight.

Hydrolyzed silk ethyl solution (20%) 0.1 Sepigel 305 * 1 5.5 Carboxyvinyl polymer 1.0 Tamarind gum 0.2 Xanthan gum 0.8 Black 401 0.3 Purple 401 0.1 Orange No. 205 0.15 Benzyl alcohol 6.0 Ethanol 15.0 Citric acid Adjust to pH 3.2 Purified water Total to 100

The hair dye of Example 12 was excellent in adhesion to hair, spreading, and dyeing properties.

Example 13 (Shampoo) A shampoo having the following composition was prepared and evaluated for foaming when the hair was washed and the moist feeling of the washed hair. The amounts are based on parts by weight.

Lauroylated hydrolyzed silk sodium solution 2.0 Sepigel 305 * 1 1.0 Sodium lauryl ether sulfate (27%) 64.0 Lauric diethanolamine 3.0 Hydroxyethylcellulose 0.3 Citric acid aqueous solution (5 %) Adjust the pH to 5.0 Preservatives Appropriate amount Purified water Adjust to a total of 100

When the hair was washed with the shampoo of Example 13, the foaming was good and the hair after washing was moist.

Example 14 (Permagel first agent) A Permagel first agent having the following composition was prepared, and the hair and the finished state of the hair after the permanent wave treatment were evaluated. The amounts are based on parts by weight.

Silylated hydrolyzed collagen * 8 1.0 Sepigel 305 * 1 0.5 Ammonium thioglycolate (50%) 12.0 Monoethanolamine (80%) 1.0 Polyoxyethylene (5) alkyl phenyl ether 3.0 Disodium edetate 0.1 Ammonia water pH 9.2 Purified water Total 100

When the hair was subjected to permanent wave treatment using the permagegel first agent of Example 14 and a 6% aqueous solution of sodium bromate as the second agent, the wave was uniform, and the hair was smooth and moist. I had a feeling.

Example 15 (Facial Cleanser) A facial cleanser having the following composition was prepared, and the moist feeling and smoothness after face washing were evaluated. The amounts are based on parts by weight.

Lauroyl hydrolyzed silk sodium liquid (20%) 2.0 Simulgel EG * 9 1.0 Sodium N-cocoylglutamate 21.0 Glycerin 9.0 Polyethylene glycol 500 15.0 Dipropylene glycol 10.0 Polyoxyethylene・ Polyoxypropylene 5.0 block polymer Polyoxyethylene (15) oleyl ether 3.0 coconut oil 1.0 Preservatives appropriate amount perfume appropriate amount Purified water Total 100 * 9; Simulgel EG (trade name); Composition comprising sodium acrylate / sodium acryloyldimethyltaurate copolymer, isohexadecane, polysorbate 80, and water

The face wash of Example 15 was excellent in moist feeling and smoothness after face washing.

Example 16 (Emulsified Foundation) An emulsified foundation having the following composition was prepared and evaluated for its spreading and moist feeling when used on the skin. The amounts are based on parts by weight.

Isostearoyl Hydrolyzed Collagen Aminomethyl 0.2 Propanediol Simulgel 600 * 10 0.5 Talc 2.8 Bengala 5.0 Yellow Iron Oxide 0.5 Black Iron Oxide 1.4 Bentonite 0.5 Polymonostearate Oxyethylene sorbitan 0.9 Triethanolamine 1.0 Propylene glycol 10.0 Stearic acid 2.2 Isostearyl alcohol 6.8 Glycerin monoisostearate 2.0 Liquid lanolin 1.5 Liquid paraffin 6.5 Perfume Appropriate Preservative Appropriate A purified water total of 100 * 10; Simulgel 600 (trade name); a composition comprising sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate 80 and water, sold by Sepic

When the emulsion type foundation of Example 16 was used, it was excellent in spreading and moist feeling.

Example 17 (Lipstick) A lipstick having the following composition was prepared and evaluated for its spreading and moist feeling when used. The amounts are based on parts by weight.

Isostearoyl hydrolyzed collagen (25%) * 11 0.1 Simulgel EG * 9 0.2 Red 201 No. 0.5 Red 202 No. 2.0 Celesin 3.5 Candelilla wax 4.0 Carnauba wax 8.0 Castor oil 30.0 glyceryl diisostearate 25.0 diisostearyl malate 5.0 polyoxyethylene (25) polyoxypropylene 1.0 (20) 2-tetradecyl ether Purified water 4.0 glycerin 5.0 propylene glycol 2.0 Perfume Appropriate amount Preservative Appropriate amount * 11; manufactured by Seiwa Kasei Co., Ltd., Promois E-118 (MO) (trade name)

When used, the lipstick of Example 17 showed
Excellent moist feeling.

Example 18 (Sunscreen) A sunscreen having the following composition was prepared and evaluated for its spreading and moist feeling when used. The amounts are based on parts by weight.

Isostearoyl hydrolyzed collagen (25%) * 11 0.1 Sepigel 305 * 1 0.15 Oxybenzone 2.0 2-Ethylhexyl paramethoxycinnamate 5.0 Squalane 10.0 Vaseline 5.0 Stearyl alcohol 2 8.8 Stearic acid 3.0 Glyceryl stearate 3.0 1,3-butylene glycol 7.0 Titanium dioxide 5.5 Triethanolamine 1.0 Chelating agent qs Preservative qs Antioxidant qs Purified water Total 100

The sunscreen of Example 18 had good spreading and moist feeling.

Example 19 (Essence) A serum having the following composition was prepared and applied to skin,
The moist feeling was evaluated. The amounts are based on parts by weight.

Isostearoyl hydrolyzed collagen (25%) * 11 0.1 Simulgel EG * 9 1.5 Macadamia nut oil 3.0 N-stearoyl sphingosine 0.2 Glycerin 5.0 1,3-butylene glycol 10.0 Preservative Suitable amount of purified water Total 100

The serum of Example 19 was excellent in spreading and moist feeling.

Example 20 (Essence) A serum having the following composition was prepared and applied to skin,
The moist feeling was evaluated. The amounts are based on parts by weight.

Isostearoyl hydrolyzed collagen (25%) * 11 0.1 Simulgel 600 * 10 3.0 Jojoba oil 1.0 Squalane 1.0 N-palmitoyl sphingosine 2.0 Hydrogenated egg yolk lecithin 2.0 Glycerin 4. 0 Dipropylene glycol 11.0 Antioxidant appropriate amount Chelating agent appropriate amount Preservative appropriate amount purified water Total 100

The essence of Example 20 was excellent in spreading and moist feeling.

[0126]

According to the present invention, when incorporated into hair cosmetics and skin cosmetics, it imparts a sufficient thickening effect to cosmetics requiring viscosity, improves combability of hair, and prevents branching of hair. In addition, it can impart gloss and moisture to the skin and smooth the skin.For hair cosmetics and skin cosmetics that do not require much viscosity, improve the combability of the hair and improve the hair's combability. It can prevent branching, impart gloss and moisture to the skin, and can smooth the skin.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 7/02 A61K 7/02 Z 7/027 7/027 7/075 7/075 7/08 7/08 7/11 7/11 7/13 7/13 7/42 7/42 7/50 7/50 // C07K 1/00 C07K 1/00 1/12 1/12 2/00 2/00 F term (reference 4C083 AA122 AB032 AB082 AB232 AB242 AB412 AB432 AB442 AC012 AC022 AC072 AC102 AC122 AC132 AC152 AC182 AC212 AC242 AC302 AC342 AC352 AC372 AC402 AC422 AC442 AC472 AC532 AC542 AC552 AC642 AC662 AC772 AC782 AC792 AD042 AD052 AD091 AD092 AD152 AD172 AD172 AD172 AD441 AD442 AD451 AD452 AD512 AD572 CC05 CC12 CC13 CC19 CC23 CC32 CC33 CC36 CC38 DD31 DD41 EE07 EE12 4H045 AA10 AA30 BA52 CA32 CA33 CA40 CA51 EA15 FA16 FA51 FA52

Claims (4)

[Claims] 1. A cosmetic comprising the following (A) and (B). (A) The following general formula (I) [In the formula, at least two of R ¹ , R ² , and R ³ are hydroxyl groups, the rest are alkyl groups having 1 to 3 carbon atoms, and R ⁴ is a basic amino acid having an amino group at a terminal of a side chain. R ⁵ represents an amino acid side chain other than R ⁴ , and A represents a bond represented by —CH ₂ —, — (C
_{H 2) 3 -, - (} CH 2) 3 OCH 2 CH (OH) CH
_{2 -, - (CH 2)} 3 S -, - (CH 2) 3 NH- and _{- (CH 2) 3 OCOCH 2} CH 2 - represents at least one group selected from the group consisting of, m is 0 200,
n is 0 to 200 and m + n is 1 to 200 (however,
m and n only indicate the number of amino acids, and do not indicate the order of the amino acid sequence)]], a silylated peptide represented by the following general formula (II): (Wherein, R ⁶ represents an amino acid side chain, p is 1 to 200, and R ⁷ represents an unsaturated or saturated linear or branched alkyl group having 1 to 22 carbon atoms) And a peptide alkyl ester represented by the following general formula (III): (Wherein, R ⁸ represents an unsaturated or saturated linear or branched alkyl group having 7 to 21 carbon atoms, R ⁹ represents an amino acid side chain, q is 1 to 200, M is sodium ,
One or more selected from the group of peptide derivatives consisting of salts of acylated peptides represented by alkali metals such as potassium and organic alkalis such as triethanolamine) (B) acrylamide / neutralized 2-acrylamide -2-
One or more selected from methylpropanesulfonic acid crosslinked copolymer, sodium acryloyldimethyltaurate copolymer, and sodium acrylate / sodium acryloyldimethyltaurate copolymer 2. The raw material protein of the peptide derivative is silk, collagen, keratin, casein, soy protein,
2. Wheat protein, casein and conchiolin.
Cosmetics described in the item. 3. The cosmetic according to claim 1, wherein the amount of one or more selected from the group of peptide derivatives is 0.01 to 15% by weight. 4. An acrylamide / neutralized 2-acrylamido-2-methylpropanesulfonic acid cross-linked copolymer,
Acryloyl dimethyl taurate sodium copolymer,
The cosmetic according to claim 1 or 2, wherein the amount of one or more selected from sodium acrylate / sodium acryloyldimethyltaurate copolymer is 0.01 to 15% by weight.