JP2002065812A - Rotary nucleated tablet-making machine - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a rotary nucleated tablet-making machine being structurally simple and having a high accuracy of the dropping position of a nucleated tablet for high reliability. SOLUTION: A plurality of plate springs 23 are radially or diagonally radially mounted on a transfer board 14 and a nucleated tablet insertion pin 27 is attached to the free end thereof and located above the nucleated tablet holding part 15 of the transfer board 14. A depressing roller 39 is provided for making contact with the head 29 of the pin 27 to depress it when the holding part 15 of the board 14 overlies a mortar hole 4 in a rotating board 5.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a rotary dry-coated tablet manufacturing machine for producing dry-coated tablets used for pharmaceuticals and the like, and more particularly to a cored tablet feeding apparatus.

[0002]

2. Description of the Related Art A dry-coated tablet used for a pharmaceutical product or the like is composed of a core tablet and a coating portion around the core tablet. Normally, the core tablet and the coating part are each mixed with a different drug or pharmaceutical composition, and unless otherwise specified, the core tablet is embedded in the center of the tablet. If the core tablet is not located in the center of the tablet, not only may the coating part be damaged or cracked, but also the expected efficacy may be impaired or unexpected side effects may occur. There is. Thus, the positioning of the core tablet greatly affects the quality of the dry tablet.

[0003] In general, a rotary dry-coated tablet manufacturing machine is used to produce a dry-coated tablet. In this rotary dry-coated tablet manufacturing machine, a plurality of die holes arranged at predetermined intervals around the circumference along the outer edge of a rotating disk rotating at a high speed are filled with drug powder, and After the core tablet is supplied and the drug powder is further filled from above the core tablet, the drug powder and the core tablet are compression-molded with a lower punch and an upper punch.

[0004] As a core tablet supply device used to supply a core tablet into a die hole of a rotary disk, a transfer disk system is frequently used from the viewpoint of speeding up. In this transfer board system, a transfer board provided with a plurality of hole-shaped or hook-shaped core lock holding portions at equal intervals along an outer edge portion is arranged so as to partially overlap above the rotating disk, and the transfer board is provided. Holding the core tablets one by one in the core lock holding part of
The transfer disk and the rotary disk are rotated in conjunction with each other, and when the core lock holding portion and the die hole of the rotary disk are vertically overlapped, the core tablet of the core lock holding portion is dropped into the die hole of the rotary disk. .

As a specific mechanism for dropping a core tablet into a die hole, a rotary push-down pin interlocked with a transfer board via a bevel gear as disclosed in JP-A-55-47859 has been used. A mechanism that pushes the core lock into the mortar by a push-down pin that swings in conjunction with the transfer board as disclosed in Japanese Patent Publication No. 62-27918. is there. As shown in FIG. 8, a cover 54 having a plurality of holes 53 corresponding to the plurality of lock holding portions 52 of the transfer board 51, and a spring 55 is provided on the upper edge of each of the holes 53 of the cover 54.
, And a lever 57 which swings in conjunction with the transfer board 51. The lever 57 presses the push pin 56 to push the core lock 58 into the die hole 59. Things have also been put to practical use.

[0006]

However, since the above-mentioned kernel lock supply device has a complicated mechanism with a large number of parts such as gears, levers, springs, pivot pins, etc. The powder adhered and deposited on these mechanical parts, causing a failure in the dropping mechanism, and the precision and reproducibility of the dropping position of the core tablet was not always high.

The present invention has been made in view of the above problems, and has a simple structure, a high accuracy of a drop position of a core tablet, and a high reliability of a rotary dry-coated tablet manufacturing machine, more specifically, An object of the present invention is to provide a core tablet supply device in a rotary dry tablet manufacturing machine.

[0008]

SUMMARY OF THE INVENTION In order to solve the above-mentioned problems, the present invention provides a rotating disk having a plurality of mortar holes arranged at equal intervals on a circumference, and a rotating disk having a plurality of mortar holes arranged from below. A tableting device having a fitted lower punch and an upper punch arranged above the die hole, and a core tablet supply device for feeding a core tablet onto the drug powder filled in the die hole of the rotary disk In the rotary dry-coated tablet manufacturing machine consisting of, the core tablet supply device has a plurality of core tablet holding parts arranged at equal intervals on a circumference circumscribing the center circle of the milling hole of the turntable. A transfer board that rotates in conjunction with the rotary board, a support board that is disposed below the transfer board, and supports the core lock held by the kernel lock holding unit from below, and a radial or A plurality of leaf springs which are mounted obliquely radially and whose free ends are located above the core lock holding portion of the transfer board; When the core lock insertion pin attached to the free end and the core lock holding portion of the transfer board are disengaged from the edge of the support board and the die hole of the rotary disc overlaps, the head comes into contact with the core lock insert pin. And a pushing-down roller.

According to the configuration of the present invention, since the lock insertion pin is attached to the free end of the leaf spring, the gear,
There are few moving parts such as levers, springs and pivot pins,
It has a simple structure and is easy to manufacture. For this reason, even if the drug powder scattered during tableting adheres and accumulates on the leaf spring or the core pin insertion pin, the dropping mechanism itself is less likely to fail, and the accuracy and reproducibility of the core tablet dropping position are reduced. Get higher.

[0010] It is preferable to further include a cover disposed above the transfer board and having a hole corresponding to the core lock holding portion. This prevents the core lock from jumping upward during transfer of the core lock held by the core lock holding unit.

It is preferable that the head of the pin insert pin which the pressing roller contacts has a curved surface. This reduces the contact area between the roller and the core lock insertion pin,
Adhesion and accumulation of the drug powder scattered during tableting is reduced, while the operation of the pressing roller getting on the head of the core lock insertion pin becomes smooth.

The leaf spring has an auxiliary leaf spring provided so as to overlap with the leaf spring. A free end of the auxiliary leaf spring is separated from a free end of the leaf spring, and the core lock is provided. It is preferable to have a long hole that engages with a groove formed on the outer periphery of the insertion pin. By doing so, the fluttering of the leaf spring at the time of retreat is suppressed, and even if the core lock insertion pin attached to the leaf spring comes off, it is possible to prevent the accidental ejection of the core lock insertion pin.

[0013]

Embodiments of the present invention will be described below with reference to the accompanying drawings.

FIG. 1 shows a dry-coated tablet manufacturing machine 1 according to the present invention.
Is shown. This dry-coated tablet manufacturing machine 1 includes a tableting device 2 and a core tablet supply device 3.

The tableting device 2 comprises a rotary disk 5 having a plurality of die holes 4 arranged at equal intervals on the circumference along the outer peripheral edge. The rotary disk 5 is driven to rotate in the direction of arrow A. As shown in FIG. 2, a lower punch 6 is fitted into each die hole 4 of the turntable 5 from below so as to be slidable up and down.
An upper punch 7 is provided above each of the mill holes 4 so as to be able to move up and down. Around the turntable 5, a first drug powder filling device 8 for performing a first step of filling the drug powder into the first layer is disposed upstream of the core tablet supply device 3, and a first layer punching device is provided downstream of the core tablet supply device 3. An upper punch compression roll 9 for performing a tableting process and a second drug powder filling device 10 for performing a second powder powder filling process are arranged, and an upper punch compression roll (not shown) for performing a second layer tableting process.
And a tablet discharging device (not shown) for performing a tablet discharging step.

The core tablet supply device 3 performs a core tablet supply step into the die hole 4, and as shown in FIG.
1 and a lower frame (not shown), a rotating shaft 13 rotatably supported between the frames via a bearing 12 and driven to rotate in synchronization with the rotating disk 5, and fixed to the rotating shaft 13. And a transfer board 14. As shown in FIG. 4, a plurality of hook-shaped notches 15 are formed on the outer periphery of the transfer board 14 at regular intervals on the circumference as a core lock holding section. Below the transfer board 14, a partially circular support board 1 that supports the core tablet C held in the notch 15 from below is provided.
6 are provided. A curved frame portion 17 having an L-shaped vertical cross section for preventing the core tablet C held in the notch portion 15 from jumping out by centrifugal force is formed on a part of the outer periphery of the support board 16. The curved frame portion 17 is provided with a core tablet supply position X described later.
Has been extended. Further, on the upstream side of the kernel lock supply position X, a kernel lock carry-in section 18 (see FIG. 1) for carrying the kernel lock C one by one into the notch 15 of the transfer board 14 is extended from the support board 16. I have.

An annular cover 19 is mounted on the transfer board 14 to prevent the lock C held in the notch 15 from jumping upward. This cover 1
9, a plurality of holes 20 are formed on the circumference having the same diameter as the center circle of the notch 15 at the same interval as the notch 15.

The transfer board 14 has the same number of steps 21 as the number of the notches 15 on the inner circumference of the center circle of the notch 15 at equal intervals. Each step 21 has a rectangular planar shape, and opposing edges of adjacent steps 21 are generally parallel. Pin 2 is located between adjacent step portions 21.
2, holes 25 and 26 formed in the fixed ends of the leaf spring 23 and the auxiliary leaf spring 24 are respectively engaged with the pin 22, whereby the leaf spring 23 and the auxiliary leaf spring 24 are radially or Mounted diagonally radially. Leaf spring 23
Is bent near the hole 25 at the fixed end so that the free end is inclined upward. The free end of the leaf spring 23 has a hole 28 into which the insertion pin 27 is inserted. As shown in FIG. 6A, the insertion pin 27 includes a conical head 29, a cylindrical shaft 30, and a flange formed around the shaft 30 near the head 29. 31. The tip of the head 29 of the insertion pin 27 is formed as a curved surface, preferably a hemispherical surface. Insertion pin 27
A leaf spring 23 is bonded or crimped to the flange portion 31 by brazing or the like. At the free end of the auxiliary leaf spring 24,
An insertion hole 32a having a diameter larger than the head 29 of the insertion pin 27 and an engagement hole 32b having substantially the same diameter as the shaft portion 30 are continuously formed as a long hole 33.
Are formed. This auxiliary leaf spring 24 has an insertion hole 32
The insertion hole 32b is engaged with the groove 31a between the head 29 and the flange 31 by being inserted into the head 29 of the insertion pin 27 and shifted in the longitudinal direction via a.

The fixed ends of the leaf spring 23 and the auxiliary leaf spring 24 are pressed and fixed by a leaf spring fixing ring 34. Outside the leaf spring fixing ring 34, a leaf spring restricting ring 35 is attached to the transfer board 14 together with the cover 19. The lower surface of the leaf spring restricting ring 35 is formed with a concave portion 36 in which the leaf spring 23 and the auxiliary leaf spring 24 are accommodated. The surface of the concave portion 36 where the leaf spring 23 and the auxiliary leaf spring 24 face each other is preferably the leaf spring 23 and the auxiliary leaf spring 24.
Are formed in parallel with the inclination of.

As shown in FIG. 3, an arm 37 is mounted on the lower surface of the upper frame 11 so as to be able to move up and down.
A roller shaft 38 is attached to the tip of the arm 37,
A push-down roller 39 that pushes down the insertion pin 27 is rotatably attached to the tip of the roller shaft 38. Also, on the upper surface of the upper frame 11, the arm 37 is provided.
And a roller height adjustment knob 40 for adjusting the height of the pressing roller 39 by raising and lowering the roller.

Next, a dry coated tablet manufacturing machine 1 having the above configuration
Will be described.

In the tableting device 2, the turntable 5 rotates in the direction of arrow A. On the other hand, in the core lock supply device 3, the transfer board 14 rotates in the direction of arrow B, and the core locks C are introduced one by one into the notch 15 of the transfer board 14 from the core lock carry-in section 18. The core tablet C introduced into the notch portion 15 is transferred to the core tablet supply position X while being supported by the support board 16 and prevented from jumping upward and outward by the cover 19 and the curved frame portion 17.

When the die hole 4 of the rotary disk 5 reaches the first drug powder filling device 8, a first drug powder layer filling step is performed. In the first medicine filling step, as shown in FIG. 5, the medicine powder first layer P1 is filled into the die hole 4 (A), the lower punch 6 is raised, and the medicine powder first layer P1 is The weight is adjusted by being cut off at the edge (B). Next, when the die hole 4 filled with the drug powder first layer P1 reaches the core tablet supply position X, a core tablet supply step is performed. In the core tablet supplying step, the core tablet C transferred by the transfer board 14 is transferred at a position a at an angle α1 with respect to a line connecting the rotary disc 5 and the axis of the transfer disc 14 as shown in FIG. It starts to enter into the die hole 4 of the rotating disk 14 approaching the position of the angle α2 with respect to the line connecting the disk 5 and the axis of the rotating disk 14. When the core lock C is further transferred and comes to a position b at an angle β with respect to a line connecting the rotary disk 5 and the axis of the transfer disk 14, the pressing roller 39 presses the core lock insertion pin 27. 6B, the insertion pin 27 is pushed down against the urging force of the leaf springs 23, 24, and the core lock C held in the notch 15 of the transfer board 14 is moved to the die. It is dropped onto the first drug powder layer P1 filled in the hole 4 (FIG. 5-C).

The core tablet supply device 3 includes leaf springs 23, 24
Since the core lock insertion pin 27 is attached to the free end of the device, the number of movable parts such as gears, levers, springs, and pivot pins is small, the structure is simple, and the manufacturing is easy. For this reason, even if the medicine powder scattered at the time of tableting adheres and accumulates on the leaf springs 23, 24 and the core tablet insertion pin 27, there is little possibility that the dropping mechanism itself will be damaged, and the drop position of the core tablet C is lowered. Accuracy and reproducibility increase. Therefore, the core tablet C can be accurately centered in the die hole 4 for a long time. Further, since the head 29 of the core tablet insertion pin 27 with which the press-down roller 39 comes into contact has a curved surface, the contact area between the press-down roller 39 and the insert pin 27 is reduced, so that the drug powder scattered at the time of tableting is reduced. While the adhesion / accumulation is reduced, the operation of the pressing roller 39 to get on the head 29 of the core lock insertion pin 27 becomes smooth.

The core tablet insertion pin 2 which has passed the core tablet supply position X
7 is retracted upward by the urging force of the leaf springs 23 and 24,
Further contact with the concave portion 36 of the leaf spring restricting ring 35 restricts further elevation. At this time, the auxiliary spring 24 is
3, the plate spring 24
Fluttering during evacuation is suppressed.

Next, when the die hole 4 to which the core tablet C is supplied reaches the upper punch compression roll 9, a temporary compression step is performed. In this temporary compression step, the upper punch 7 is driven and descends into the die hole 4, whereby the core tablet C and the first chemical powder P1 in the die hole 4 are compressed by the upper punch 7 and the lower punch 6. (Fig. 5-
D). Thereafter, the upper punch 7 rises (FIG. 5-E), and the lower punch 6 descends.

After the step of temporarily compressing the core tablet C and the first layer of drug powder P1, when the mortar 4 reaches the second drug powder filling device 10, the step of filling the second layer of drug powder is performed. In this step, the drug powder second layer P2 is filled in the die hole 4 (FIG. 5-F), the lower punch 6 is raised, and the drug powder is cut off at the edge of the die hole 4 to adjust the weight. (Fig. 5-
G).

Next, when the die hole 4 filled with the second layer P2 of drug powder reaches an upper punch compression roll (not shown), a second compression step is performed. In the second compression step, similarly to the temporary compression step, the upper punch 7 is driven and descends into the die hole 4, whereby the second layer P2 in the die hole 4 has already been temporarily compressed. Together with the tablet C and the first layer of drug powder P1, they are compression molded with the upper punch 7 and the lower punch 6 (FIG. 5-H). afterwards,
The upper punch 7 rises, the lower punch 6 also rises, and the formed tablet T
Is pushed up to above the die hole 4 (FIG. 5-I).

When the die 4 reaches a tablet discharge device (not shown), the pushed-up tablet T is discharged along a guide (not shown) (FIG. 5J).

In the dry coated tablet manufacturing machine 1 of the above-described embodiment, the cleaning which has been performed once every several hours in the past can be performed once a month. Further, it has been confirmed that the number of eccentric defective products of the core tablet C is reduced, and the yield is increased by about 4.5% as compared with the conventional case.

[0031]

As is apparent from the above description, according to the present invention, since the lock insert pin is attached to the free end of the leaf spring, the movable parts of the gears, levers, springs, pivot pins, etc. can be moved. Fewer parts, simple structure, and easy to manufacture. For this reason, even if the drug powder scattered during tableting adheres and accumulates on the leaf spring or the core pin insertion pin, the dropping mechanism itself is less likely to fail, and the accuracy and reproducibility of the core tablet dropping position are reduced. Get higher. As a result, the number of eccentric defective products of the core tablet is reduced and the yield is improved, while the cleaning interval is extended, almost maintenance-free and for a long time.
Operation can be performed with high accuracy, and there is an effect that production efficiency is improved.

[Brief description of the drawings]

FIG. 1 is a plan view of a rotary dry-coated tablet manufacturing machine according to the present invention.

FIG. 2 is a sectional view taken along line II of FIG. 1;

FIG. 3 is a sectional view taken along line II-II of FIG. 1;

FIG. 4 is an exploded perspective view of a core tablet supplying device of the rotary dry tablet manufacturing machine of FIG. 1;

FIG. 5 is a view showing a manufacturing process by the rotary dry-coated tablet manufacturing machine of FIG. 1;

6A is a cross-sectional view showing operations of a leaf spring, a core lock insertion pin, and a pressing roller immediately after supply of a core lock, and FIG.

FIG. 7 is a plan view for explaining a positional relationship between a core tablet and a die hole.

FIG. 8 is a cross-sectional view showing a core tablet supply device of a conventional rotary dry-coated tablet manufacturing machine.

[Explanation of symbols]

 REFERENCE SIGNS LIST 1 cored tablet manufacturing machine 2 tableting device 3 core tablet supply device 4 die hole 5 rotary disk 6 lower punch 7 upper punch 14 transfer plate 15 notch (core tablet holding portion) 16 support plate 19 cover 23 leaf spring 24 auxiliary Leaf spring 27 Core lock insertion pin 33 Slot 39 Press down roller

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Hidenori Asae 121-1 Nakayamaya, Torino, Oga-cho, Koka-cho, Koka-gun, Shiga Prefecture Inside the Shiga Plant of Bayer Yakuhin Co., Ltd. 121-1 Nakayamaya, Torii character, Bayer Yakuhin Co., Ltd., Shiga Factory (72) Inventor Tatsu Sakaguchi, Naigayamaya, Toriiino character, Koka-cho, Koka-gun, Shiga Prefecture 121-1 Bayer Yakuhin, Ltd. Shiga Factory

Claims (4)

[Claims] 1. A rotating disk having a plurality of mortar holes arranged at equal intervals on a circumference, a lower punch fitted into the mortar hole of the rotating disk from below, and disposed above the mortar hole. A rotary tablet press machine comprising: a tableting device having an upper punch; and a core tablet supply device for supplying a core tablet onto a drug powder filled in a die hole of the rotary disk. The apparatus has a plurality of core lock holding parts arranged at equal intervals on a circumference circumscribing the center circle of the die hole of the rotary disk, a transfer disk rotating in conjunction with the rotary disk, and the transfer A support board disposed below the board and supporting the core lock held by the core lock holding section from below; and a radial or obliquely radially attached to the transfer board, the free end of which is the core lock of the transfer board. A plurality of leaf springs located above the holding portion; a lock insert pin attached to a free end of the leaf spring; When the core lock holding portion of the board is disengaged from the edge of the support board and the mortise hole of the rotary disc overlaps, the presser comprises a press-down roller which comes into contact with the head of the core lock insertion pin and presses down. Formulated dry coated tablet making machine. 2. The rotary dry-coated tablet manufacturing machine according to claim 1, further comprising a cover disposed above the transfer board and having a hole corresponding to the core tablet holding portion. 3. The head of the pin insertion pin with which the pressing roller contacts has a curved surface.
Or the rotary dry-coated tablet manufacturing machine according to 2. 4. The leaf spring has an auxiliary leaf spring provided so as to overlap with the leaf spring, and the auxiliary leaf spring is engaged with a slot formed in a groove formed on an outer periphery of the core lock insertion pin. 4. The rotary dry-pressed tablet machine according to claim 1, wherein