JP2002053458A - Low-irritation cleansing preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a means for inhibiting irritation development without impairing cleansing power in an anionic surfactant-containing cleansing preparation. SOLUTION: The objective low-irritation cleansing preparation is obtained by incorporating an anionic surfactant-containing cleansing preparation with a polyoxyethylene fatty acid glyceryl ester.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a stimulant reducing agent for anionic surfactants and a cleansing agent for sensitive skin containing the same.

[0002]

2. Description of the Related Art Anionic surfactants such as soap are excellent in solubilizing or dispersing both greasy stains and aqueous stains, and have been widely used as a washing component of aqueous detergents since ancient times. I have. Contrary to such excellent detergency of anionic surfactants, these substances may sometimes cause irritation of humans with sensitive skin, and the expression of such irritation may be caused by these anionic surfactants. Was a drawback. Means for suppressing the expression of such stimuli have been studied for a long time, and a method using an amphoteric surfactant instead of an anionic surfactant, and adding a specific polyhydric alcohol such as 1,4-butanediol And a method of changing the counter ion to a relatively weak base such as triethanolamine have been developed.However, the use of amphoteric surfactants sacrifices detergency, and the addition of polyhydric alcohol reduces foaming. May be impaired, and for weak bases,
Other safety such as diethanolamine may be suspected, and no definitive measures have been obtained at present. Furthermore, in today's stress overload is becoming more common, the rapid increase in sensitive skin caused by such stresses has further increased the demand for the development of such soap stimulating means. That is, in a detergent containing an anionic surfactant, it has been desired to develop a means for suppressing the occurrence of irritation without impairing the detergency.

On the other hand, in cosmetics containing anionic surfactants, it has never been known that the addition of glyceryl polyoxyethylene fatty acid suppresses the stimulus expression of such anionic surfactants. However, it has not been known at all to produce a cleansing agent for sensitive skin by combining an anionic surfactant with glyceryl polyoxyethylene fatty acid.

[0004]

DISCLOSURE OF THE INVENTION The present invention has been made under such circumstances, and a means for suppressing the occurrence of irritation in a detergent containing an anionic surfactant without impairing the detergency. The task is to provide

[0005]

In view of such a situation, the present inventors have developed a detergent containing an anionic surfactant,
As a result of diligent research efforts in search of means for suppressing the occurrence of irritation without deteriorating the detergency, it was found that polyoxyethylene fatty acid glyceryl has an excellent effect of suppressing irritation of an anionic surfactant, and the invention Was completed. That is, the present invention relates to the following technology. (1) consisting of polyoxyethylene fatty acid glyceryl,
Stimulant reducing agent for anionic surfactants. (2) The stimulant reducing agent for an anionic surfactant according to (1), wherein the fatty acid composition of the polyoxyethylene fatty acid glyceryl is constituted by a fatty acid derived from coconut oil. (3) 1) one or two or more selected from the stimulants of the anionic surfactant according to (1) or (2) and 2)
A cleaning agent for sensitive skin, comprising one or more selected from anionic surfactants. (4) The cleaning agent according to (3), wherein the anionic surfactant is a fatty acid soap or a sulfate-based anionic surfactant. (5) A method for reducing irritation of an irritant, which comprises adding polyoxyethylene fatty acid glyceryl. (6) The method for reducing irritation according to (5), wherein the stimulant is an anionic surfactant. (7) The method for reducing irritation according to (5) or (6), wherein the fatty acid composition of the polyoxyethylene fatty acid glyceryl is constituted by a fatty acid derived from coconut oil. (8) 1) One or two or more selected from the stimulant reducing agents for the anionic surfactant according to (1) or (2) and 2).
A cleaning agent for sensitive skin, characterized by containing polyoxyethylene fatty acid glyceryl. (9) The cleaning agent for sensitive skin according to (8), wherein the anionic surfactant is a fatty acid soap or a sulfate-based anionic surfactant. (10) The cleaning agent for sensitive skin according to (8) or (9), wherein the fatty acid composition of the polyoxyethylene fatty acid glyceryl is constituted by a fatty acid derived from coconut oil. Hereinafter, the present invention will be described in more detail focusing on embodiments.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION (1) The agent for reducing irritation of the anionic surfactant of the present invention The agent for reducing irritation of the anionic surfactant of the present invention comprises polyoxyethylene fatty acid glyceryl. Here, suitable fatty acid moieties of the polyoxyethylene fatty acid glyceryl include lauric acid, myristic acid, and palmitic acid. 1 selected from stearic acid, behenic acid, caprylic acid, caproic acid, oleic acid, linoleic acid, linoleic acid, etc.
Seeds or two or more can be exemplified, and these are tallow, coconut oil,
It is also possible to hydrolyze natural or processed fats and oils such as olive oil and hydrogenated products thereof to extract the fatty acid portion, or to further purify and use the fatty acid portion. Among these polyoxyethylene fatty acid glyceryls, a particularly preferable one is a fatty acid glyceryl derived from polyoxyethylene coconut oil. Polyoxyethylene fatty acid glyceryl, including polyoxyethylene coconut oil fatty acid glycerin, is a raw material widely used as a nonionic surfactant in the field of skin external preparations such as cosmetics, and this is already commercially available. , Those things can be used. In this composition, the number of moles of polyoxyethylene added can be appropriately changed depending on the purpose of use, but in the liquid composition for an impregnated sheet of the present invention, the impregnation of the sheet, which is the object of the present invention, In order to improve the usability in the above-mentioned form, the average number of moles of polyoxyethylene added is preferably from 5 to 15, more preferably from 5 to 10. As such a polyoxyethylene fatty acid glyceryl and, in particular, a polyoxyethylene coconut oil fatty acid glycerin, a commercially available product is preferably Hyber Oil HE (average number of added moles of polyoxyethylene: 7) manufactured by Koyo Fine Chemical Co., Ltd. Further, a part or all of the fatty acid constituting the coconut oil fatty acid is purified, that is, separated into fatty acids such as lauric acid, caprylic acid, capric acid and the like, and polyoxyethylene (derived from coconut oil) fatty acid glyceryl is used. Also belongs to the technical scope of the present invention. Such materials include polyoxyethylene (1
0) Cethiol HE810 (manufactured by Henkel) having caprylic acid / glyceryl caprate as a main component is preferred. As the stimulant reducing agent for the anionic surfactant of the present invention, the detergent of the present invention may contain only one kind of these polyoxyethylene fatty acid glycerins, or may contain two or more kinds thereof in combination. You can also. The preferable content of the polyoxyethylene fatty acid glycerin is preferably 0.1 to 20% by weight, more preferably 1 to 10% by weight, based on the total amount of the detergent. This is because the effect of suppressing the stimulus expression is remarkable in this content range. Further, as described above, since the polyoxyethylene fatty acid glyceryl has a function as a surfactant, even when the polyoxyethylene fatty acid glyceryl is contained for sensitive skin in anticipation of such a function of the surfactant, the present invention is also applicable. Such a case also belongs to the technical scope of the present invention because the anionic surfactant functions as a stimulus reducing agent.

(2) Anionic surfactant which is an essential component of the detergent of the present invention The detergent of the present invention contains an anionic surfactant as an essential component. Such anionic surfactants can be used without any particular limitation as long as they are usually used in the field of detergents. For example, alkyl sulfates,
Polyoxyethylene alkyl sulfates, sulfate-based anionic surfactants such as sulfosuccinate salts, alkyl phosphates, phosphate-based anionic surfactants such as polyoxyethylene alkyl phosphates, laurate, myristate,
Fatty acid soaps such as palmitate, stearate, oleate and behenate can be preferably exemplified. Of these, particularly preferred are alkyl sulfates and fatty acid soaps. Examples of the salt include alkali metal salts such as sodium and potassium, ammonium salts, organic amine salts such as triethylamine and triethanolamine, and basic amino acid salts such as lysine and arginine. Among them, alkali metal salts are particularly preferable. Can be illustrated. These anionic surfactants may contain only one kind, or may contain two or more kinds in combination. The preferred content of the anionic surfactant in the detergent of the present invention varies depending on the dosage form, but is preferably 1 to 60% by weight, more preferably 10 to 50% by weight. This is because excellent cleaning action can be exhibited in this range.
In addition, it is preferable that the amount of the anionic surfactant is 2 to 30 times by weight of the polyoxyethylene fatty acid glyceryl from the viewpoint of maintaining detergency.

(3) Sensitive skin cleansing agent of the present invention The sensitive skin cleansing agent of the present invention is characterized by containing the above essential components. Since the stimulus expression of the cleaning agent for sensitive skin of the present invention is suppressed by the stimulus expression reducing agent, even a person with sensitive skin who feels irritation with a normal cleaning agent can use the irritation hardly. The cleansing agent for sensitive skin of the present invention may contain, in addition to the above-mentioned essential components, any components usually used for cleaning. Examples of such optional components include esters such as carnauba wax and octyldodecyl oleate, silicones such as dimethicone, femethicone, and amomedicone; triglycerides such as olive oil, tallow, and coconut oil; stearic acid, oleic acid, and ritinoleic acid. Fatty acids such as oleyl alcohol, stearyl alcohol, higher alcohols such as octyldodecanol, polyhydric alcohols such as polyethylene glycol, glycerin, 1,3-butanediol, isoprene glycol, 1,2-pentanediol, and thickeners / gels Examples include agents, antioxidants, ultraviolet absorbers, coloring agents, preservatives, powders, and active ingredients. Among them, a particularly preferable one is to contain isoprene glycol in order to further suppress the irritation and supplement the skin moisturizing function. The preferred content of such isoprene glycol is 1 to 20% by weight, more preferably 5 to 15% by weight. By treating the optional component and the essential component according to a conventional method, the cleaning agent for sensitive skin of the present invention can be produced.

[0009]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples, but it goes without saying that the present invention is not limited only to these Examples.

<Example 1> The effect of the anionic surfactant of the present invention as a stimulant reducing agent was examined. That is, the samples shown in Table 1 were prepared, and a patch test was performed using 39 boys. That is, apply the sample to the lint cloth of the patch
After charging 5 ml, the solution was stuck on the back for 24 hours, and 24 hours after the bandage was removed, the reaction was judged according to the Japanese patch test standard. That is, ++: reaction with edema or papule, +:
Reaction with clear erythema, ±: reaction with indistinct erythema,
-: No reaction, positive reaction or more was defined as positive reaction. Table 1 shows the incidence of positive reactions. This indicates that the stimulus onset reducing agent of the anionic surfactant of the present invention suppresses stimulus onset in a dose-dependent manner. Potassium laurate 3% Hiber Oil HE (Cethiol HE810) Water remaining in Table 1 (to 100%)

[0011]

<Embodiment 2> Samples 1, 4 and
5 was replaced with 0.3% sodium lauryl sulfate, and a patch test was similarly conducted with 42 boys.
The sample not containing E810 also had a positive reaction appearance rate of 11.
In contrast to 9%, the rate of occurrence of a positive reaction was 0 in both cases of containing 10% of Hiber oil HE and 10% of cethiol HE810, and the effect of the stimulant reducing agent of the anionic surfactant of the present invention was It was confirmed that the composition covers all anionic surfactants.

<Example 3> A cleaning agent of the present invention was prepared for sensitive skin according to the following formulation. That is, the components (a) and (b) were each heated to 80 ° C., and (b) was added to (a) while stirring, and the mixture was stirred and cooled to obtain a milky liquid detergent. This was used as a sensitive skin, and nine people who could not use a normal cleaning agent were used as panelists, and a use test was conducted. As a condition of the test, it was mentioned that the use test was stopped immediately when a feeling of irritation or abnormal skin was felt. In the two-week use test, the number of persons who stopped the test due to the above-mentioned unfavorable event was 0, indicating that the cleansing agent for sensitive skin of the present invention can be used extremely safely by persons with sensitive skin. Was. I myristic acid 3 parts by weight Lauric acid 7 parts by weight Hiber oil HE 5 parts by weight Isoprene glycol 10 parts by weight glycerin 20 parts by weight Caustic potash 1.25 parts by weight L-arginine 4.43 parts by weight Dipotassium glycyrrhizinate 0.5 parts by weight Water 48.82 parts by weight

Example 4 A cleansing composition of the present invention was prepared for sensitive skin according to the following formulation. That is, the components (a) and (b) were each heated to 80 ° C., and (b) was added to (a) while stirring, and the mixture was stirred and cooled to obtain a milky liquid detergent. This was used as a sensitive skin, and 12 people who could not use a normal cleaning agent were used as panelists, and a use test was conducted. As a condition of the test, it was mentioned that the use test was stopped immediately when a feeling of irritation or abnormal skin was felt. In the two-week use test, the number of persons who stopped the test due to the above-mentioned unfavorable event was 0, indicating that the cleansing agent for sensitive skin of the present invention can be used extremely safely by persons with sensitive skin. Was. I myristic acid 3 parts by weight lauric acid 7 parts by weight cethiol HE810 5 parts by weight isoprene glycol 10 parts by weight b glycerin 20 parts by weight caustic potash 1.25 parts by weight L-arginine 4.43 parts by weight dipotassium glycyrrhizinate 0.5 parts by weight water 48 .82 parts by weight

Example 5 According to the following formulation, the cleaning composition of the present invention was prepared for sensitive skin. That is, the components (a) and (b) were each heated to 80 ° C., and (b) was added to (a) with stirring, and the mixture was stirred and cooled to obtain a creamy detergent. This was aged at 40 ° C. for one week to obtain a pearly creamy detergent. This was used as a sensitive skin, and nine people who could not use a normal cleaning agent were used as panelists, and a use test was conducted. As a condition of the test, it was mentioned that the use test was stopped immediately when a feeling of irritation or abnormal skin was felt. In a two-week use test, the number of people who discontinued the test due to the undesired event was 0,
It has been found that the cleansing agent for sensitive skin of the present invention can be used extremely safely by persons with sensitive skin. I Stearic acid 18 parts by weight Palmitic acid 6 parts by weight Myristic acid 6 parts by weight Lauric acid 10 parts by weight Hiber oil HE 2 parts by weight Lo glycerin 10 parts by weight Isoprene glycol 2 parts by weight Caustic potash 7.8 parts by weight 1,3-butanediol 3 0.5 parts by weight Dipotassium glycyrrhizinate 0.5 parts by weight Water 34.2 parts by weight

<Example 6> According to the following formulation, the cleaning agent of the present invention was prepared for sensitive skin. That is, the components (a) and (b) were each heated to 80 ° C., and (b) was added to (a) with stirring, and the mixture was stirred and cooled to obtain a creamy detergent. This was aged at 40 ° C. for one week to obtain a pearly creamy detergent. This was used as a sensitive skin, and five people who could not use ordinary cleaning agents were made panelists, and a use test was conducted. As a condition of the test, it was mentioned that the use test was stopped immediately when a feeling of irritation or abnormal skin was felt. In a two-week use test, the number of people who discontinued the test due to the undesired event was 0,
It has been found that the cleansing agent for sensitive skin of the present invention can be used extremely safely by persons with sensitive skin. I Stearic acid 18 parts by weight Palmitic acid 6 parts by weight Myristic acid 6 parts by weight Lauric acid 10 parts by weight Hiber oil HE 10 parts by weight Lo glycerin 10 parts by weight Isoprene glycol 2 parts by weight Caustic potash 7.8 parts by weight 1,3-butanediol 3 0.5 parts by weight Dipotassium glycyrrhizinate 0.5 parts by weight Water 26.2 parts by weight

Example 7 According to the following formulation, the cleaning composition of the present invention was prepared for sensitive skin. That is, the components (a) and (b) were each heated to 80 ° C., and (b) was added to (a) with stirring, and the mixture was stirred and cooled to obtain a creamy detergent. This was aged at 40 ° C. for one week to obtain a pearly creamy detergent. This was used as a sensitive skin, and seven people who could not use a normal cleaning agent were used as panelists, and a use test was conducted. As a condition of the test, it was mentioned that the use test was stopped immediately when a feeling of irritation or abnormal skin was felt. In a two-week use test, the number of people who discontinued the test due to the undesired event was 0,
It has been found that the cleansing agent for sensitive skin of the present invention can be used extremely safely by persons with sensitive skin. I Stearic acid 18 parts by weight Palmitic acid 6 parts by weight Myristic acid 6 parts by weight Lauric acid 10 parts by weight Hiber oil HE 20 parts by weight Lo glycerin 10 parts by weight Isoprene glycol 2 parts by weight Caustic potash 7.8 parts by weight 1,3-butanediol 3 0.5 parts by weight Dipotassium glycyrrhizinate 0.5 parts by weight Water 16.2 parts by weight

Example 8 According to the following formulation, the cleansing composition of the present invention was prepared for sensitive skin. That is, the components (a) and (b) were each heated to 80 ° C., and (b) was added to (a) with stirring, and the mixture was stirred and cooled to obtain a creamy detergent. This was aged at 40 ° C. for one week to obtain a pearly creamy detergent. This was used as a sensitive skin, and eight people who could not use a normal cleaning agent were made panelists, and a use test was conducted. As a condition of the test, it was mentioned that the use test was stopped immediately when a feeling of irritation or abnormal skin was felt. In a two-week use test, the number of people who discontinued the test due to the undesired event was 0,
It has been found that the cleansing agent for sensitive skin of the present invention can be used extremely safely by persons with sensitive skin. 2. stearic acid 18 parts by weight palmitic acid 6 parts by weight myristic acid 6 parts by weight lauric acid 10 parts by weight cethiol HE810 20 parts by weight b glycerin 10 parts by weight isoprene glycol 2 parts by weight caustic potash 7.8 parts by weight 1,3-butanediol 3. 5 parts by weight Dipotassium glycyrrhizinate 0.5 part by weight Water 16.2 parts by weight

[0019]

According to the present invention, it is possible to provide a means for suppressing the occurrence of irritation in a detergent containing an anionic surfactant without impairing the detergency.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (reference) C11D 1/83 C11D 1/83 F term (reference) 4C083 AB032 AC112 AC122 AC242 AC421 AC422 AC582 AD532 BB05 CC23 DD32 DD33 EE12 4H003 AB03 AB44 AC12 DA02 EA21 EB04 EB05 EB12 EB41 ED02 FA02

Claims (10)

[Claims] A stimulant reducing agent for an anionic surfactant comprising glyceryl polyoxyethylene fatty acid. 2. The stimulant reducing agent for an anionic surfactant according to claim 1, wherein the fatty acid composition of the polyoxyethylene fatty acid glyceryl is constituted by a fatty acid derived from coconut oil. 3. One or two or more selected from the stimulants of the anionic surfactant according to claim 1 and 2) One or two or more selected from the anionic surfactants A cleaning agent for sensitive skin, characterized by comprising: 4. The cleaning agent according to claim 3, wherein the anionic surfactant is a fatty acid soap or a sulfate-based anionic surfactant. 5. A method for reducing irritation of an irritant, comprising adding glyceryl polyoxyethylene fatty acid. 6. The method for reducing irritation according to claim 5, wherein the stimulant is an anionic surfactant. 7. The method for reducing irritation according to claim 5, wherein the fatty acid composition of the polyoxyethylene fatty acid glyceryl is composed of a fatty acid derived from coconut oil. 8. A composition comprising: 1) one or more selected from the stimulants of the anionic surfactant according to claim 1 or 2; and 2) glyceryl polyoxyethylene fatty acid. Cleanser for sensitive skin. 9. The cleaning agent for sensitive skin according to claim 8, wherein the anionic surfactant is a fatty acid soap or a sulfate-based anionic surfactant. 10. The cleaning agent for sensitive skin according to claim 8, wherein the fatty acid composition of the polyoxyethylene fatty acid glyceryl is constituted by a fatty acid derived from coconut oil.