JP2002003382A - Nutrient auxiliary composition for promoting articular cartilage regeneration and inhibiting cartilage reduction - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an effective nutrient auxiliary composition for promoting articular cartilage regeneration and inhibiting cartilage reduction that is not given by conventional nutrient auxiliary compositions for facilitating articular cartilage regeneration and inhibiting cartilage reduction. SOLUTION: This nutrient auxiliary composition for promoting articular cartilage regeneration and inhibiting cartilage reduction is obtained by formulating 1 mg-500 mg of soybean-derived isoflavone and a soybean extract containing isoflavones to 100 mg-3,000 mg/once of a group containing glucosamine, glucosamine salt, N-acetyl glucosamine and N-acetyl glucosamine salt which are obtained by using chitin and chitin hydrolysates capable of being isolated from crab, lobster, prawn or shrimp as main materials, an amino sugar independently containing these glucosamines or an amino sugar composition obtained by selectively mixing these glucosamines.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention has an effect of promoting regeneration of articular cartilage and preventing cartilage loss, and is used for foods and pharmaceuticals useful for prevention and treatment of joint and connective tissue diseases such as osteoarthritis. The aim is to obtain a composition that can be used.

[0002]

2. Description of the Related Art Conventionally, a composition containing a component or precursor of cartilage and connective tissue is orally or intravenously administered for the treatment and prevention of damage and arthritis of cartilage and connective tissue and maintenance of the state of treatment. The method was used.

[0003] That is to say, by administering orally or intravenously, glucosamine and chondroitin sulfate or a natural extract containing these, which are the main components of proteoglycan constituting connective tissue, and the other main component collagen, It supplied raw materials for the biosynthesis of cartilage and connective tissue in the body.

[0004]

[Problems to be Solved by the Invention] From our sales experience, oral administration of a composition for treatment and prevention with conventional components of connective tissue and maintenance of the state of treatment,
It has been found that the therapeutic effect in women, especially in postmenopausal women, is lower or longer in a certain period of time than males.

[0005] In a medical institution, glucosamine sulfate 1000 was given to patients with knee osteoarthritis in their 50s to 80s.
As a result of orally administering the composition adjusted to mg / day for one month, improvement symptoms were confirmed by consciousness and consultation of a doctor in an average of 75 to 90% of patients. However, the average for women alone was around 65%, confirming that the effect was clearly lower than for men.

An object of the present invention is to make up for the disadvantages of the conventional compositions and to obtain a composition having an effect of promoting articular cartilage regeneration and preventing cartilage loss even in postmenopausal women.

[0007]

[Means for Solving the Problems] After the menopause of a woman, the suppression of the secretion of parathyroid hormone is released by decreasing the secretion of estrogen, a kind of female hormone. As a result, it is known that production of cytokines such as interleukin I, VI and prostaglandin E2, which cause osteoporosis and pain due to a decrease in the amount of bone calcium salt due to bone resorption, is increased. (References Masuzuwa
T. et al. : J. Clin. Invest. 94,
1090 (1994))

[0008] In the biochemical considerations of chondrocytes in patients with osteoarthritis, the production of chondrocyte-destructing enzymes proteoglycanase, collagenase, and elastase has increased from the initial stage. (References Ichi Inoue: Diagnosis and treatment of osteoarthritis, p.13, Medical School, Tokyo, (1
994))

It is known that cytokines such as interleukin I and VI and prostaglandin E2 are involved in the chondrocyte degradation system. (References Ichi Inoue: Diagnosis and treatment of osteoarthritis, p.13, Medical School, Tokyo,
(1994)) Therefore, in women with hormonal balance modulation after menopause, chondrocytes continue to produce destructive enzymes even if the synthesis system becomes active by administration of the major components of connective tissue, so that synthesis and degradation occur. This led to the fact that it took a long time for the therapeutic effect to be achieved due to the balance between the two.

[0010] It has been noted that isoflavones derived from soybeans, which have a rich dietary experience since ancient times, are effective for improving climacteric disorders for Japanese people. ing.

Research on the involvement of female hormones, cytokines and isoflavones in female hormone receptors and bone metabolism is progressing. Since there is a common feature between bone metabolism and cartilage metabolism, isoflavones have a role in cartilage metabolism. The contribution is predictable.

However, what is expected from the action of isoflavones is suppression of cartilage destruction, which is not linked to fundamental cartilage regeneration.

[0013] In the present invention, the progress of cartilage degradation is achieved by a two-sided method of suppressing cartilage degradation and simultaneously promoting cartilage regeneration by combining isoflavones with a composition having a sufficient track record in cartilage regeneration. It is characterized by a remarkable improvement in the effect of promoting cartilage and connective tissue regeneration in women after early menopause.

[0014]

Embodiments of the present invention will be described based on examples, but the present invention is not limited to these examples.

[0015]

[Example 1] As a prescription for one grain, glucosamine sulfate 200 mg, soy isoflavone 7 mg, lactose 100 m
g, reduced maltose syrup 70 mg, sucrose fatty acid ester 10
The tablets were mixed at a ratio of mg, and tablets were obtained by a direct tableting method.

[0016]

Example 2 N-acetylglucosamine (50 mg), soybean isoflavone (7 mg), lactose (100 mg), reduced maltose syrup (70 mg), and sucrose fatty acid ester (10 mg) were mixed, and tablets were obtained by a direct tableting method.

[0017]

According to the present invention, the composition as described in Examples 1 and 2 is effective. The dietary supplement composition for promoting articular cartilage regeneration and preventing cartilage loss formulated according to the present invention is a combination of a composition that has a sufficient track record in cartilage regeneration and isoflavones, and suppresses cartilage degradation and regenerates cartilage. From the two sides that promote cartilage degradation, cartilage degradation progresses rapidly, resulting in a dramatic improvement in postmenopausal women.

[0018] A method using glucosamine and chondroitin sulfate in combination to enhance the cartilage regeneration function (Patent No. 2)
No. 971579) has been published.

Chondroitin sulfate suppresses the enzymatic activity of decomposing cartilage macromolecules. (References Solda
ni, G .; , And Romanmagnoli, J .; : Dr
ugs in experimental and C
linearResearch, 18, (1) 81
-85, (1991)) antagonizes enzymes that inhibit cartilage nutrient supply. (References Rovetta, G .: D
lugsin experimental and C
linear Research 18, (1) 5
3-57, (1991)) and the like, and a synergistic effect is expected, but there is no report as to whether chondroitin sulfate acts synergistically in the presence of glucosamine. It is self-evident that chondroitin sulfate has a structure in which two units of D-glucuronsan and galactosamine are repeated several tens of times, and when administered orally, is degraded by gastric acid during the process of absorption and metabolism and is used as a constituent of cartilage. It is. In other words, it is considered that the cartilage is replenished with the same components as the conventional method.

According to the present invention, a remarkable improvement in the effect of promoting cartilage and connective tissue regeneration in postmenopausal women with rapid cartilage degradation is achieved by a two-sided method of suppressing cartilage degradation and simultaneously promoting cartilage regeneration. It can be said that it is different from the old method.

According to the statistics of the Ministry of Health and Welfare,
The number of patients with osteoarthritis began to increase around the age of 45,
It reaches its maximum at the age of five. In particular, the number of female patients is
More than doubled. In 1993, the total number of patients in Japan was assumed to be one million or more. However, with the aging of society, the role of the present invention in maintaining the health of the Japanese people is very large.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 35/78 A61K 35/78 J A61P 19/02 A61P 19/02

Claims (7)

[Claims] 1. An amino sugar comprising glucosamine, a glucosamine salt, N-acetylglucosamine, an N-acetylglucosamine salt containing chitin and a chitin hydrolyzate as a main material, or an amino sugar composition solely or selectively mixed therewith. A nutritional supplement composition for promoting articular cartilage regeneration and preventing cartilage loss, comprising a soybean-derived isoflavone and a soybean extract containing isoflavone. 2. The composition of claim 1, wherein the single dose of the amino sugar is from 200 mg to 3,000 mg. 3. The composition according to claim 2, wherein a single dose of the soybean extract is 15 mg to 500 mg. 4. The composition according to claim 1, wherein the amino sugar is glucosamine (including glucosamine salt), and the single dose is 200 mg to 3,000 mg. 5. The composition according to claim 4, wherein a single dose of soybean extracted isoflavone (including aglycone) is 3 mg to 3 mg.
A composition that is 100 mg. 6. The composition according to claim 1, wherein a single dose of N-acetylglucosamine (including N-acetylglucosamine salt) is 100 mg to 3,000 mg. 7. The composition according to claim 6, wherein the single dose of soybean extracted isoflavone (including aglycone) is from 3 mg to 3 mg.
A composition that is 100 mg.