JP2002003351A - Dentifrice composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a dentifrice composition containing a fluoride ion-supplying compound capable of improving retaining properties of fluorine in the oral cavity, excellent in preservation stability as a dentifrice, and capable of being effectively utilized as the dentifrice for preventing tooth decay. SOLUTION: This dentifrice composition is characterized in that a wax is included in the dentifrice composition containing the fluoride ion-supplying compound, and one or more kinds of perfume components selected from anethole, carvone, cineole, methyl salicylate, eugenol, ethyl butyrate and cinnamaldehyde, and 1-menthol in the weight ratio of (1:20)-(5:1).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dentifrice composition containing a fluorine ion-supplying compound.
The present invention relates to a dentifrice composition having improved retention of fluorine in the oral cavity and storage stability.

[0002]

2. Description of the Related Art
In the field of anti-caries dentifrice, compounding a fluorine ion supplying compound such as sodium fluoride or sodium monofluorophosphate as an active ingredient is performed. In this type of dentifrice, in order to improve the effect, a technique for increasing the retention of fluorine ion-supplying compound in the oral cavity has been developed. There is a demand for improvement.

On the other hand, in dentifrices, a phenomenon often occurs in which liquid separation occurs with the passage of time, but liquid separation hardly occurs even after long-term storage at a high temperature, and a dentifrice with high storage stability is desired.

An object of the present invention is to provide a dentifrice composition which satisfies the above-mentioned demands, has high fluorine retention in the oral cavity, and hardly causes liquid separation during storage.

[0005]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, compounded a wax with a dentifrice composition containing a fluorine ion supplying compound. In addition, it has been found that by combining a specific flavor component such as anethole and l-menthol in a specific ratio in combination, fluorine retention in the oral cavity is improved and storage stability is also improved. I've reached the point.

That is, according to the present invention, a dentifrice composition containing a fluorine ion-supplying compound contains a wax and is selected from anethole, carvone, cineole, methyl salicylate, eugenol, ethyl butyrate and cinamic aldehyde. Provided is a dentifrice composition characterized in that one or more flavor components are mixed with l-menthol at a mass ratio of 1:20 to 5: 1.

Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention contains a fluorine ion-supplying compound as an anti-caries component. As the fluorine ion supplying compound, fluorides such as sodium fluoride and stannous fluoride;
One or more kinds of alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate can be used. The compounding amount of the fluorine ion supplying compound is 1 as fluorine ion.
00 ppm to 2000 ppm, preferably 200 ppm
ppm to 1500 ppm is suitable. If the compounding amount is less than 100 ppm, a sufficient effect cannot be expected.
If m is exceeded, the possibility of fluorosis occurs.

In the present invention, a wax is blended in order to improve the retention of fluorine. As wax,
Specifically, vegetable waxes such as candelilla wax, carnauba wax, cane wax, wood wax, white wax and rice wax, and animal waxes such as beeswax, whale wax and insect white wax can be used. The content of the present wax is usually 0.001 to 10% (mass percentage, the same applies hereinafter), preferably 0.005 to 5%, more preferably 0.01 to 2% of the whole composition. If it is less than 0.001%, a sufficient fluorine retention effect cannot be seen, and if it exceeds 10%, a peculiar off-taste or odor may be generated.

In the present invention, further, anethole, carvone, cineole, methyl salicylate, eugenol,
One or two or more flavor components selected from ethyl butyrate and cinnamic aldehyde are blended with l-menthol, and among the above flavor components, anethole can be most preferably used. In addition, each of the above-mentioned fragrance components may be blended as a single substance, but an essential oil or the like containing them, for example, spearmint oil may be blended in the case of carvone. Further, l-menthol, which is used in combination with the above-mentioned perfume component, may be blended as a single substance, but essential oils containing the same, such as peppermint oil and Japanese peppermint oil, may also be used.

The mixing ratio of the total amount of the above-mentioned perfume components and l-menthol is 1:20 to 5: 1 by mass ratio, preferably 1: 1.
The ratio is 10 to 2: 1. By blending in this ratio range, the retention of fluorine in the oral cavity can be increased, and liquid separation of the preparation can be effectively prevented. In addition, the compounding quantity of the said fragrance | flavor component is 0.01 to the whole composition.
It is preferably 1.0%, particularly 0.1 to 0.6%, and the blending amount of l-menthol is preferably 0.2 to 2.0%, particularly 0.3 to 1% of the whole composition. 0.0%.

The composition of the present invention may contain other perfume components in addition to the above perfume components and l-menthol.

[0012] The composition of the present invention comprises an abrasive, a binder, a thickener, a humectant, a surfactant, and a surfactant which are usually blended in a dentifrice composition.
Sweeteners, colorants, preservatives, storage stabilizers, pH adjusters,
Appropriate components such as medicinal components can be blended within a range that does not significantly impair the effects of the present invention.

In this case, the abrasives include calcium phosphate compounds such as dibasic calcium phosphate dihydrate and anhydrate, monobasic calcium phosphate, tribasic calcium phosphate, calcium pyrophosphate, calcium carbonate, calcium hydroxide, alumina, anhydrous Inorganic abrasives such as silicic acid, aluminum silicate, insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, zirconium silicate, titanium-bound silicate, polymethyl methacrylate, crystalline cellulose And other organic abrasives. The amount of the abrasive is usually 5 to 60% of the total composition, preferably 8 to 50%.
%.

Examples of the binder include cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, and hydroxyethylcellulose; gums such as xanthan gum, tragacanth gum, karaya gum, and gum arabic; polyvinyl alcohol; cross-linked sodium polyacrylate; Examples include carboxyvinyl polymers such as sodium acrylate, organic binders such as polyvinylpyrrolidone, and inorganic binders such as silica gel, aluminum silica gel, veegum, and laponite. The amount of the binder is usually 0.2% of the whole composition.
~ 2%.

As the thickener and humectant, polyhydric alcohols such as sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol and maltitol, and sugar alcohols are blended. Is done.

As the surfactant, an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant can be blended. Examples of the anionic surfactant include sodium alkyl sulfate such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosinate such as sodium N-lauroyl sarcosinate, sodium N-myristoyl sarcosine, sodium dodecylbenzene sulfonate, hydrogen N-acyl glutamates such as added coconut fatty acid monoglyceride, sodium monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurine, N-methyl-N-
Examples include sodium acylalanine and sodium α-olefin sulfonate. Nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester and sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol Polyhydric alcohol fatty acid esters such as fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene copolymers, polyoxyethylene alkyl phenyl ethers, ether type activators such as polyoxyethylene hydrogenated castor oil, lauric acid diethanolamide And alkanolamides such as fatty acids. Examples of the cationic surfactant include an alkyl ammonium, an alkyl benzyl ammonium salt and the like. Betaine acetate, as an amphoteric surfactant,
Imidazolinium betaine, lecithin and the like.

As a sweetener, sodium saccharin,
Stevioside, neohesperidyl dihydrochalcone,
Glycyrrhizin, perillartin, p-methoxycinnamic aldehyde, aspartame, xylitol and the like can be blended.

The coloring agents include Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 2
No. 04, green No. 3, titanium mica, titanium oxide and the like.

Examples of the preservative include sodium benzoate, methylparaben, propylparaben, butylparaben, cetylpyridinium chloride, isopropylmethylphenol, potassium sorbate and the like.

Examples of the storage stabilizer include vitamin C, vitamin E, sodium sulfite, sodium pyrosulfite, sodium hydrogen sulfite, butylhydroxytoluene, propyl gallate, butylhydroxyaryl and the like.

Examples of the pH adjuster include citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, pyrophosphoric acid, glycerophosphoric acid and various salts thereof, and sodium hydroxide. PH of the dentifrice composition of the present invention
Is adjusted to be in the range of 5 to 9, preferably 6 to 8.

Examples of the active ingredient include antibacterial agents such as chlorhexidine, triclosan, cetylpyridinium chloride, and hinokitiol; plaque formation inhibitors such as dextranase, mutanase, and protease; Examples include calcin preventives such as plasmin and polyphosphates, gum tightening agents such as sodium chloride, and various vitamins such as tocopherol acetate.

[0023]

The dentifrice composition containing the fluorine ion-supplying compound of the present invention has improved fluorine retention in the oral cavity,
Moreover, it has excellent storage stability as a dentifrice, and can be effectively used as an anti-carious dentifrice.

[0024]

EXAMPLES The present invention will be specifically described below with reference to experimental examples and examples, but the present invention is not limited to the following examples. In the following example, "fragrance"
It is a preparation free of anethole, carvone, cineol, methyl salicylate, eugenol, ethyl butyrate and cinamic aldehyde and l-menthol.

Experimental Example A dentifrice containing the components shown in Table 1 was prepared. 1 g of this dentifrice was taken on a toothbrush and used for 3 minutes, and the mouth was rinsed three times with 60 mL of water. 10,2
The fluorine concentration in saliva was measured after 0 and 30 minutes. Further, 90 g of the dentifrice is filled into a laminate tube,
The state of liquid separation after storage for 6 months was evaluated. The scores are as follows. Note that rice wax or carnauba wax was used as the wax. Liquid separation score ◎: No liquid separation observed ○: Almost no liquid separation observed ×: Liquid separation observed

[0026]

[Table 1]

From the results in Table 1, it can be seen that sodium fluoride or sodium monofluorophosphate is used in combination with rice wax or carnauba wax, and that the flavor component A (anethole, carvone, cineole, methyl salicylate, eugenol, ethyl butyrate, It is recognized that the combined use of (cinnamic aldehyde) and l-menthol increases the retention of fluorine in the oral cavity and provides good results for liquid separation. On the other hand, the dentifrice containing no wax (Comparative Example 1) has a low retention of fluorine in the oral cavity, and the system containing the wax does not use the fragrance component A and l-menthol (Comparative Example 2). ,
3) is inferior in the retention of fluorine in the oral cavity,
Liquid storage occurred after storage for 6 months, and the storage stability of the dentifrice was low. In terms of improving liquid separation, the combination of anethole and l-menthol was the best.

The following is a formula example. Example 10 Propylene glycol 3.0% Sorbitol (70%) 40.0 Sodium carboxymethyl cellulose 1.5 Sodium saccharin 0.2 Triclosan 0.3 Rice wax 0.3 Silicic anhydride 20.0 Titanium oxide 0.5 Paraoxy Methyl benzoate 0.1 Sodium fluoride 0.2 Sodium lauryl sulfate 1.5 Lauroyl sarcosinate 0.3 Dextranase 0.1 1-Menthol 0.5 Anethole 0.1 Perfume 0.3 Water Balance 100. 0%

Example 11 Silica 15.0% Thickening Silica 3.0 Polyethylene Glycol 400 3.0 85% Glycerin 8.0 Xylitol 1.0 Sodium Carboxymethyl Cellulose 1.4 Sodium Lauryl Sulfate 1.2 Paraoxybenzoic Acid Butyl 0.1 Sodium fluoride 0.23 Carnauba wax 0.5 l-Menthol 0.6 Carvone 0.3 Methyl salicylate 0.1 Perfume 0.1 Water Balance 100.0%

Example 12 Calcium Phosphate Dihydrate 35.0% Thickening Silica 3.0 Propylene Glycol 3.0 Saccharin Sodium 0.2 Sodium Alginate 0.8 Xanthan Gum 0.4 Sodium Lauryl Sulfate 1.0 Benzoic Acid Sodium 0.5 sodium monofluorophosphate 0.76 dextranase 0.2 shellac 0.25 l-menthol 0.5 anethole 0.1 cineole 0.1 methyl salicylate 0.1 fragrance 0.3 water balance 100. 0%

Example 13 Silica 20.0% Thickening Silica 3.0 Polyethylene Glycol 400 5.0 70% Sorbit 15.0 Carrageenan (Iota) 0.5 Saccharin Sodium 0.2 Xanthan Gum 0.5 Sodium Lauryl Sulfate 1 0.3 Myristinic acid diethanolamide 1.0 Methyl parahydroxybenzoate 0.1 Sodium fluoride 0.23 Candelilla wax 0.1 1-Menthol 0.3 Eugenol 0.3 Perfume 0.5 Water Balance 100.0%

Example 14 Aluminum hydroxide 42.0% Thickening silica 2.0 Propylene glycol 5.0 70% Sorbit 15.0 Saccharin sodium 0.2 Sodium alginate 1.0 Sodium lauryl sulfate 1.2 Paraoxybenzoic acid Methyl 0.2 Sodium monofluorophosphate 0.76 Rice wax 0.25 1-Menthol 0.6 Carvone 0.2 Cinnamic aldehyde 0.1 Fragrance 0.1 Water Balance 100.0%

Example 15 Calcium Phosphate Dihydrate 40.0% Thickening Silica 2.0 Propylene Glycol 3.0 85% Glycerin 20.0 Saccharin Sodium 0.2 Carrageenan (Iota) 0.4 Xanthan Gum 0.8 Sodium lauryl sulfate 1.2 Methyl parahydroxybenzoate 0.2 Sodium monofluorophosphate 0.76 Dextranase 0.1 Carnauba wax 0.5 1-Menthol 0.7 Cineol 0.2 Ethyl butyrate 0.1 Fragrance 0.2 water balance 100.0%

Example 16 Silica 15.0% Thickening Silica 3.0 Propylene Glycol 3.0 70% Sorbite 35.0 Saccharin Sodium 0.2 Carboxymethyl Cellulose Sodium 1.2 Sodium Lauryl Sulfate 1.0 Methyl Paraoxybenzoate 0.1 sodium fluoride 0.23 rice wax 0.1 l-menthol 0.3 anethole 0.2 carvone 0.2 perfume 0.2 water balance 100.0%

Example 17 Aluminum hydroxide 40.0% Thickening silica 3.0 Propylene glycol 3.0 70% Sorbite 25.0 Saccharin sodium 0.2 Sodium alginate 0.3 Carrageenan (iota) 0.3 Lauryl sulfate Sodium 0.7 Myristate diethanolamide 1.2 Methyl parahydroxybenzoate 0.1 Sodium monofluorophosphate 0.76 Wood wax 0.2 l-Menthol 0.5 Methyl salicylate 0.1 Ethyl butyrate 0.1 Fragrance 0 0.3 water balance 100.0%

Example 18 Silica 20.0% Thickening Silica 3.0 Polyethylene Glycol 400 0.3 70% Sorbit 15.0 85% Glycerin 20.0 Saccharin Sodium 0.2 Sodium Alginate 0.6 Xanthan Gum 0.5 Sodium lauryl sulfate 0.8 ethyl paraoxybenzoate 0.1 sodium fluoride 0.23 candelilla wax 0.5 l-menthol 0.5 cinamic aldehyde 0.3 perfume 0.3 water balance 100.0%

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Noriyuki Monoi 1-3-7, Honjo, Sumida-ku, Tokyo Inside Lion Corporation (72) Inventor Takeki Ikenishi 1-3-7, Honjo, Sumida-ku, Tokyo 4C083 AA072 AA122 AB172 AB222 AB242 AB282 AB332 AB472 AC122 AC132 AC211 AC212 AC341 AC342 AC471 AC472 AC482 AC642 AC662 AC782 AC812 AC842 AC862 AD042 AD272 AD302 AD352 AD472 AD532 BB41 CC41 DD22 EE01 EE07 EE

Claims (1)

[Claims] 1. A dentifrice composition containing a fluoride ion-supplying compound containing a wax and one or two selected from anethole, carvone, cineole, methyl salicylate, eugenol, ethyl butyrate and cinnamaldehyde. A dentifrice composition comprising the above fragrance component and l-menthol in a mass ratio of 1:20 to 5: 1.