JP2001348319A - Liniment composition for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a liniment composition for skin excellent in appearance, stability and feeling in use, capable of highly penetrating ceramides and oil soluble vitamins to the skin. SOLUTION: This liniment composition for skin includes ceramides and oil soluble vitamins, a 1-4C lower alcohol and an ester oil and/or a 14-22C higher alcohol.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a skin coating composition containing a ceramide, an oil-soluble vitamin, a lower alcohol having 1 to 4 carbon atoms and an ester oil and / or a higher alcohol having 14 to 22 carbon atoms. About.

[0002]

2. Description of the Related Art Ceramides and oil-soluble vitamins are hardly soluble in low-polarity oily components such as water and hydrocarbons. Dispersion methods have been used.
However, in recent years, consumers have tended to prefer a refreshing type of skin application, and an oily type has been avoided. Further, when dispersed in oil, there is a tendency that the feeling of use is rough and lacks smoothness.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide a skin coating composition which is excellent in appearance, stability and usability, and has high penetration of ceramides and oil-soluble vitamins into the skin. is there.

[0004]

The gist of the present invention is to provide ceramides, oil-soluble vitamins, lower alcohols having 1 to 4 carbon atoms, ester oils and / or higher alcohols having 14 to 22 carbon atoms. Skin coating composition comprising:

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The skin coating composition of the present invention comprises a ceramide and an oil-soluble vitamin together with a C1 to C4.
Lower alcohols and ester oils and / or C14
~ 22 higher alcohols, so that the penetration of ceramides and oil-soluble vitamins into the skin is high, and not only can ceramides and oil-soluble vitamins effectively act on the skin, By improving the solubility of ceramides and oil-soluble vitamins and controlling the total amount of oil in the formulation to a small amount, there is little stickiness,
A skin application composition with a good feeling in use is obtained.

As ceramides, ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7, animal brain extract, phytoceramide, glycosphingopide (plant ceramide), ceraminol, ceramide Plant extracts such as compresses; natural ceramides such as ceramide-sphingosine complex and ceraplex and mixtures thereof; optically active ceramide 2
(Ceramide TIC-001), synthetic optically active ceramides such as optically active ceramide 3, O-acyl ceramide, stearoyl dihydrosphingosine, stearoyl phytosphingosine, hydroxyethyl palmityloxyhydroxypropyl palmitamide (ceramide SL), trihydroxy palmita Midohydroxypropyl myristyl ether (ceramide H03), N- (hexadecyloxyhydroxypropyl) -N-hydroxyethyldecanamide, N- (hexadecyloxyhydroxypropyl) -N
One or more kinds of synthetic pseudo-ceramides such as -hydroxyethylhexadecanamide and the like can be used in combination, and among these, N- (hexadecyloxyhydroxypropyl) -N-hydroxyethyldecanamide can be used. Do, N
-(Hexadecyloxyhydroxypropyl) -N-hydroxyethylhexadecanamide and ceramide complex are preferred.

The content of the ceramide is preferably 0.01 to 10% by weight in the skin coating composition from the viewpoints of the stability and appearance of the skin coating composition, the feeling of use, and the effect of maintaining the skin barrier. 0.1 to 10% by weight is more preferable,
-5% by weight is more preferred.

[0008] Oil-soluble vitamins include vitamin A
Oil, retinol acetate, retinol palmitate, dl-
α-tocopherol, dl-α-tocopherol acetate,
One or two or more of tocopherol nicotinate, natural vitamin E, ergocalciferol, cholecalciferol, animal and vegetable oils containing them can be used as a mixture, and among these, vitamin A oil and natural vitamin E is preferred.

The content of the oil-soluble vitamins is preferably 0.01 to 5% by weight in the skin coating composition from the viewpoints of the stability, appearance and skin activating effect of the skin coating composition. 0.1 to 2% by weight is more preferred.

The lower alcohol having 1 to 4 carbon atoms includes:
One or more kinds of monohydric alcohols having a linear or branched alkyl group can be used as a mixture,
Among them, ethanol and isopropanol are preferred from the viewpoint of safety to the human body.

The content of the lower alcohol having 1 to 4 carbon atoms is preferably 0.1 to 10% by weight in the skin coating composition from the viewpoint of the stability, appearance, and feeling of use of the skin coating composition. , 0.2 to 5% by weight.

The ester oils are compounds obtained by dehydrating an acid component such as a fatty acid, a polybasic acid or a hydroxy acid and an alcohol component such as a lower alcohol, a higher alcohol or a polyhydric alcohol, and include cetyl isooctanoate,
Isopropyl palmitate, octyl palmitate, 2-octyldodecyl myristate, cetyl 2-ethylhexanoate, diisostearyl malate, isononyl isononanoate, isotridecyl isononanoate, isostearyl myristate, neopentyl glycol dioctanoate, neodicaprate neo One or a mixture of two or more of pentyl glycol, octyldodecyl lactate, di (2-heptylundecyl) adipate, glyceryl tri (capryl / caprate), and glyceryl tri-2-ethylhexanoate can be used. Of these, branched fatty acid esters such as cetyl isooctanoate and glyceryl tri-2-ethylhexanoate are preferred.

As the higher alcohol having 14 to 22 carbon atoms, one or a mixture of two or more of myristyl alcohol, cetanol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, octyldodecanol, hexyldecanol and the like can be used. Of these, higher alcohols that are liquid at normal temperature, such as oleyl alcohol, octyldodecanol, and hexyldecanol, are preferred.

The total content of the ester oils and the higher alcohols having 14 to 22 carbon atoms is determined from the viewpoint of the stability, appearance, and feeling of use of the skin coating composition.
It is preferably from 1 to 80% by weight, more preferably from 3 to 60% by weight, particularly preferably from 5 to 50% by weight.

The method for preparing the skin coating composition of the present invention is not particularly limited. For example, a mixture comprising ceramides, oil-soluble vitamins, ester oils, higher alcohols and the like is heated to about 70 to 90 ° C. Further, a method of preparing by adding a water-soluble component containing a lower alcohol heated to the same temperature as the mixture, or a mixture of ceramides, oil-soluble vitamins, ester oils, higher alcohols and the like, and a water-soluble component Is heated to about 70 to 90 ° C., mixed, and emulsified, then cooled to about 65 ° C., and a lower alcohol is added together with a fragrance or the like to prepare.

In the present invention, ester oils having 14 to 14 carbon atoms are used.
In addition to the 22 higher alcohols, known oily raw materials used for pharmaceuticals, quasi-drugs, cosmetics, and the like may be appropriately contained.

The oily raw materials include animal and vegetable oils such as avocado oil and olive oil, hydrocarbons such as squalane, petrolatum, liquid paraffin, higher fatty acids such as palmitic acid and stearic acid, and silicones such as methylpolysiloxane. No.

Further, the skin coating composition of the present invention contains a humectant such as glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, maltitol and the like, which are commonly used for pharmaceuticals, quasi-drugs, cosmetics and the like. Agents, colorants, fragrances, powders, ultraviolet absorbers, pH adjusters, antioxidants, germicidal preservatives, sequestering agents, vitamins, anti-inflammatory agents, plant extracts, etc. Is also good.

[0019]

Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to only these examples.

Examples 1 to 3 and Comparative Examples 1 and 2 Components 1 to 6 shown in Table 1 were mixed, stirred, heated to about 80 ° C., mixed, and further heated to about 80 ° C. 1
After slowly adding 1 under stirring, the mixture was cooled to room temperature under stirring to obtain a creamy skin coating composition. The appearance, stability, and feeling of use of the obtained skin coating composition were evaluated according to the following evaluation criteria. Table 1 shows the results.

Examples 4 and 5, Comparative Example 3 Components 1 to 7 shown in Table 2 were mixed, stirred, heated to about 80 ° C, mixed, and further heated to about 80 ° C. After slowly adding under stirring, cool to about 65 ° C., add components 9 to 11, and cool to room temperature under stirring,
Each of the creamy skin application compositions was obtained. The appearance, stability, and feeling of use of the obtained skin coating composition were evaluated according to the following evaluation criteria. Table 2 shows the results.

[Appearance] The state immediately after production is visually evaluated. “◎” indicates a glossy and completely uniform state, “○” indicates a uniform but slightly less glossy state, “△” indicates a non-glossy state, and “×” indicates a state of separation or precipitation of crystals.

[Stability] “◎” indicates room temperature, 40 ° C. or 5
When stored under the condition of ℃, those whose appearance was stable for more than one month, “△” indicates that the crystals separated or precipitated within one month, and “×” indicates that the crystals separated or precipitated immediately after the production. This is shown.

[Feeling of use] The feeling of use in the panel test by 10 women was evaluated as "refreshing,""somewhatrefreshing,""sticky," and "hope for continued use" (multiple answers allowed). The evaluation is made based on four items, and the number of people for each item is shown.

[0025]

[Table 1]

[0026]

[Table 2]

From these results, in all of Examples 1 to 5, excellent results were obtained in all of appearance, stability and feeling of use. However, in Comparative Example 1, ceramide was precipitated, and in Comparative Example 2, It can be seen that the feeling of use is not very good, and that Comparative Example 3 lacks stability and sticky during use.

Further, the skin coating compositions of Example 2 and Comparative Example 2 were applied to the forearm, and Sebumeter SM-810 (manufactured by COURAGE + KHAZAKA, Germany) was used to compare skin permeability.
Was used to measure the amount of skin surface lipid after application. Immediately after the application, the application site in Comparative Example 2 had oil shine on the skin surface, but in Example 2, there was no difference compared to before application. Table 3 shows the results.

[0029]

[Table 3]

As a result, in Example 2, the amount of skin surface lipid was
After 6 hours, the value was 30 μg / cm ^2, which was higher than that before the application. However, in Comparative Example 2, the oil content was reduced to 6 μg / cm ² after 4 hours. Penetrated into the skin and maintained the skin barrier function for more than 6 hours,
In Comparative Example 2, it can be seen that the oil peeled off from the skin surface.

[0031]

Industrial Applicability According to the present invention, it has become possible to provide a skin coating composition which is excellent in appearance, stability and usability, and has high penetration of ceramides and oil-soluble vitamins into the skin.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 47/16 A61K 47/16 47/44 47/44 F-term (Reference) 4C076 AA16 BB31 CC23 DD37 DD44 DD52 DD69 EE51 FF16 FF34 GG46 4C083 AA082 AB032 AC012 AC022 AC071 AC072 AC101 AC102 AC122 AC242 AC331 AC332 AC342 AC422 AC641 AD222 AD611 AD622 AD662 CC02 CC05 EE06

Claims (3)

[Claims] 1. A skin coating composition comprising a ceramide, an oil-soluble vitamin, a lower alcohol having 1 to 4 carbon atoms, an ester oil and / or a higher alcohol having 14 to 22 carbon atoms. 2. The skin coating composition according to claim 1, wherein the content of the ceramide is 0.01 to 10% by weight. 3. The skin coating composition according to claim 1, wherein the content of the lower alcohol having 1 to 4 carbon atoms is 0.1 to 10% by weight.