JP2001299931A - Chemical injecting device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a chemical injecting device allowing the locally efficient administration of a chemical to an affected part. SOLUTION: This chemical injecting device 1 comprises a tubular body 3 put on the circumference of a stent 2 and a thermosensitive gel 4 impregnated with a chemical 5, which covers the circumference of the tubular body 3.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is used for the improvement of stenosis in a living body such as a blood vessel or for the treatment of cancer. The present invention relates to a drug injection device that can be administered.

[0002]

2. Description of the Related Art
Most stents used for the improvement of stenosis and in the treatment of cancer in a living body such as a blood vessel are made of metal such as stainless steel or a Ti-Ni-based shape memory alloy, and thrombus or blood clot is easily formed. About 2 weeks after the operation until the stent is covered with the endothelial cells, it is necessary to administer an anticoagulant such as heparin for supplementary therapeutic purposes. For this reason, depending on the state of the patient, there is a risk that side effects may cause complications such as bleeding. Therefore, without administration of anticoagulants, etc.
If the drug can be directly and locally administered to the affected area, the above-mentioned complications will not occur, and the treatment period can be shortened. The inventors of the present invention have conducted intensive studies in order to solve the above problems, and as a result, have arrived at the next invention.

[0003]

Means for Solving the Problems [1] The present invention relates to a drug in which a tubular body 3 is covered on the outer periphery of a stent 2 and a thermosensitive gel 4 in which the outer periphery of the tubular body 3 is impregnated with a drug 5 is coated. Injection device 1
I will provide a. [2] The present invention provides a drug injection device 11 in which an extension 13 is attached to the tip of a shaft 12 and the outer periphery of the extension 13 is covered with a thermosensitive gel 14 impregnated with a drug 15. [3] According to the present invention, the thermosensitive gel 4 (14) undergoes a phase transition at a body temperature or slightly higher than the body temperature and contracts to release the impregnated drug 5 (15). 1
The drug injection device 1 according to [1] or [2], which is 4).
(11) is provided.

[0004]

DESCRIPTION OF THE PREFERRED EMBODIMENTS In the present invention, a stent 2 is made of, for example, Ni.
-Superelastic metal such as Ti alloy, stainless steel (SUS-31
6L), a tubular body formed by knitting a wire made of a metal such as tantalum into a mesh shape and having excellent self-expandability is used. In the present invention, the tubular body 3 is made of, for example, polyethylene terephthalate, polytetrafluoroethylene, H
A tubular body substantially equivalent to that used for a known artificial blood vessel or the like made of a material such as an EMA-styrene copolymer and having excellent biocompatibility is used.

In the present invention, the temperature-sensitive gel 4 (14) is defined as a body temperature (in the range of 35 ° C. to 38 ° C. depending on the individual difference) or a temperature slightly higher than the body temperature (depending on the individual difference, 1% below the body temperature).
° C to 3 ° C, preferably 1 ° C to 2 ° C higher temperature: about 3
(7 ° C. to about 41 ° C., preferably about 38 ° C. to about 40 ° C.), which can undergo phase transition and contract to release the impregnated drug 5 (15). More specifically, thermosensitive gel 4
(14) refers to a substance which absorbs water at a temperature lower than a phase transition temperature (hereinafter referred to as Tf) and swells, and contracts at a temperature exceeding the Tf to release water (a drug impregnated with water). In the present invention, the thermosensitive gel 4 (14) refers to a thermosensitive responsive polymer hydrogelated, and the thermosensitive gel 4 (14) impregnated with the drug 5 (15) refers to the thermosensitive gel 4 (14). Refers to a gel obtained by further treating the hydrogel 4 (14) with a hydrous drug. In the present invention, the following (a) to (f) can be used as the thermoresponsive polymer. (A) Those having a phase transition temperature slightly higher than body temperature. For example, hydroxypropyl methylcellulose (Tf: 41
C), poly (N-vinylisobutylamide) (Tf: 3
9 ° C.). (B) The phase transition temperature can be adjusted to a body temperature or a temperature slightly higher than the body temperature by molecular design. For example, partially saponified polyvinyl alcohol (homopolymer), poly (N-vinylamide-vinyl acetate)
Copolymers and the like. (C) a polymer whose phase transition temperature can be controlled at body temperature or at a temperature slightly higher than body temperature by molecular weight. For example, polyvinyl oxazolidinone, polyethylene oxide and the like. And (d) a combination of one polymer selected from the above (a) to (c) and another polymer (which does not necessarily have to have a thermoresponsive property). For example, it is a poly (N-isopropylacrylamide-acrylic acid) copolymer or the like. (E) In addition, for example, methyl cellulose, partially saponified polyvinyl acetate, acrylate / N-vinyl-
2-pyrrolidone copolymer and the like. (F) A polymer that undergoes a phase transition at a temperature lower than the body temperature with one polymer selected from the above (a) to (e), for example, polyvinyl methyl ether (Tf: 30 ° C.), poly (N-isopropylacrylamide (Tf: 31 ° C.) or the like to control the phase transition temperature to body temperature or a temperature slightly higher than body temperature.

[0006] In the present invention, the drug 5 can be used in the following Table 1 as an effective drug for improving the stenosis of the affected part (blood vessel).

[Table 1]

[0007] In addition to the above, drugs effective for treating cancer, such as gene therapy drugs, nucleic acid-related antimetabolites, antineoplastic drugs and the like can also be used. Any material that can be impregnated into the thermosensitive gel 4 (14) can be used.

FIG. 1 is a schematic view showing an example of the drug injection device 1 of the present invention (FIG. 2 is a cross-sectional view of the drug injection device 1). The drug injection device 1 of the present invention is covered with a stent 2 and a crown. A thermosensitive gel 4 impregnated with a drug 5 is coated on the outer periphery of the tubular body 3.

Next, an example of a method of using the medicine injection device 1 of the present invention will be described. (A) As shown in FIG. 3 (a), the drug injection device 1 (the thermosensitive gel 4 is made to absorb water at a temperature equal to or lower than Tf and is expanded) is stored in the catheter 6 in a contracted state. I do. (B) After inserting the catheter 6 into the affected area as shown in FIG. 3B in the same manner as the normal stent fixing means, the drug injection device 1 is released from the tip of the catheter 6, and the drug injection device 1 is expanded. The outer periphery of the drug injection device 1 is brought into close contact with the inner wall surface of the affected part. (C) A fluid supply tube (not shown) is inserted into the inside of the medicine injection device 1, and a fluid heated to a body temperature or higher is supplied into the tube. The thermosensitive gel 4 on the outer periphery of the drug injection device 1 is gradually contracted by the heating fluid to release water, and the drug 5 is released together with the water. Thereby, the medicine 5 is intensively administered to the affected area. After the administration of the medicine 5, the medicine injection device 1 can be collected, for example, by loading it into a collection tube or fixing it to the outer periphery of a balloon.

FIG. 4 is a schematic view of a drug injection device 11 showing another embodiment of the drug injection device of the present invention. The drug injecting device 11 has an extension 13 attached to the tip of the shaft 12,
Thermosensitive gel 1 in which drug 15 is impregnated on the outer periphery of extension 13
4 are coated. Further, from the side surface of the shaft 12, through the inside of the shaft 12 and the inside of the extension portion 13, the extension portion 13
The guide wire tube 17 is disposed up to the end of the guide wire. The front and rear ends of the guide wire tube 17 have openings 18F and 18B, and the inside is a guide wire lumen 19. The drug injection device 11 of the present invention is substantially the same as a balloon dilatation catheter used for percutaneous coronary angioplasty (PTCA) except that the outer periphery of the dilation portion 13 is coated with the thermosensitive gel 14. Can be used. If necessary, in the drug injection device 11 of the present invention, positioning markers 20 (for example, X-ray opaque ones such as gold and platinum) may be formed at both ends of the expansion part 13 as shown in FIG.

Next, an example of a method of using the medicine injection device 11 of the present invention will be described. (A) Similar to a normal PTCA balloon dilatation catheter, the dilation part 13 of the drug injection device 11 is fixed to the inner wall surface of the affected part as shown in FIG. (B) As shown in FIG. 4, a heating fluid is supplied into the expansion section 13 through the fluid supply lumen 16 to expand the expansion section 13,
The outer periphery of the thermosensitive gel 14 is brought into close contact with the inner wall surface of the affected part. (C) The thermosensitive gel 14 is contracted by the fluid to release water, and the medicine 15 is released together with the water. As a result, the medicine 15 is intensively administered to the affected area.

[0012]

As described above, the drug injection device 1 (11) of the present invention can efficiently and locally administer the drug 5 (15) to the affected area, so that there is no occurrence of joint venture and treatment can be performed. It can be done in a short time with peace of mind.

[Brief description of the drawings]

FIG. 1 is a schematic diagram of a drug injection device of the present invention.

FIG. 2 is a cross-sectional view of the drug injection device of the present invention.

FIG. 3 is a view showing a use state of the drug injection device of the present invention.

FIG. 4 is a schematic diagram of a drug injection device of the present invention.

[Explanation of symbols]

 1 Drug Injection Device 2 Stent 3 Tubular Body 4 Thermosensitive Gel 5 Drug 6 Catheter 11 Drug Injection Device 12 Shaft 13 Expansion Portion 14 Thermosensitive Gel 15 Drug 16 Fluid Supply Lumen 17 Guide Wire Tube 18F, 18B Opening 19 Guide Lumen for wire 20 Marker

Claims (3)

[Claims] 1. A drug injection device 1 comprising a tubular body 3 covered on the outer periphery of a stent 2, and a thermosensitive gel 4 impregnated with a drug 5 coated on the outer periphery of the tubular body 3. 2. A drug injecting device 11 wherein an extension portion 13 is attached to a tip of a shaft 12, and an outer periphery of the extension portion 13 is covered with a thermosensitive gel 14 impregnated with a drug 15. 3. The thermosensitive gel 4 (14) capable of undergoing a phase transition at a body temperature or slightly higher than the body temperature and shrinking to release the impregnated drug 5 (15). The medicine injection device 1 (11) according to claim 1 or 2, characterized in that: